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Aliases for PTCRA Gene

Aliases for PTCRA Gene

  • Pre T-Cell Antigen Receptor Alpha 2 3 5
  • PT-Alpha-TCR 3 4
  • PT-ALPHA 3 4
  • PTA 3 4
  • Pre-T-Cell Receptor Alpha Chain 3

External Ids for PTCRA Gene

Previous GeneCards Identifiers for PTCRA Gene

  • GC06P042885
  • GC06P042931
  • GC06P042932
  • GC06P042992
  • GC06P042883
  • GC06P042601

Summaries for PTCRA Gene

Entrez Gene Summary for PTCRA Gene

  • The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for PTCRA Gene

PTCRA (Pre T-Cell Antigen Receptor Alpha) is a Protein Coding gene. Diseases associated with PTCRA include Granulomatous Orchitis and Shoulder Impingement Syndrome. Among its related pathways are Notch signaling pathway (Pathway Interaction Database) and C-MYB transcription factor network.

UniProtKB/Swiss-Prot for PTCRA Gene

  • The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTCRA Gene

Genomics for PTCRA Gene

Regulatory Elements for PTCRA Gene

Enhancers for PTCRA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTCRA on UCSC Golden Path with GeneCards custom track

Genomic Location for PTCRA Gene

Chromosome:
6
Start:
42,915,807 bp from pter
End:
42,925,838 bp from pter
Size:
10,032 bases
Orientation:
Plus strand

Genomic View for PTCRA Gene

Genes around PTCRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTCRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTCRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTCRA Gene

Proteins for PTCRA Gene

  • Protein details for PTCRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ISU1-PTCRA_HUMAN
    Recommended name:
    Pre T-cell antigen receptor alpha
    Protein Accession:
    Q6ISU1
    Secondary Accessions:
    • Q5TFZ7

    Protein attributes for PTCRA Gene

    Size:
    281 amino acids
    Molecular mass:
    29266 Da
    Quaternary structure:
    • Heterodimer with TCRB; disulfide linked. This heterodimer assembles with CD3 proteins into a signaling-competent pre-T-cell receptor complex. Interacts with RHBDD1.

    Three dimensional structures from OCA and Proteopedia for PTCRA Gene

    Alternative splice isoforms for PTCRA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTCRA Gene

Proteomics data for PTCRA Gene at MOPED

Post-translational modifications for PTCRA Gene

  • Glycosylation at Asn 67
  • Modification sites at PhosphoSitePlus

Other Protein References for PTCRA Gene

No data available for DME Specific Peptides for PTCRA Gene

Domains & Families for PTCRA Gene

Protein Domains for PTCRA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PTCRA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PTCRA: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PTCRA Gene

Function for PTCRA Gene

Molecular function for PTCRA Gene

GENATLAS Biochemistry:
pre-T-cell receptor alpha chain,invariant,heterodimerizing with TCRbeta chain receptor in immature thymocyte
UniProtKB/Swiss-Prot Function:
The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development.
genes like me logo Genes that share phenotypes with PTCRA: view

Animal Models for PTCRA Gene

MGI Knock Outs for PTCRA:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTCRA Gene

Localization for PTCRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTCRA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTCRA Gene COMPARTMENTS Subcellular localization image for PTCRA gene
Compartment Confidence
plasma membrane 4
extracellular 3
nucleus 2
cytoskeleton 1
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for PTCRA Gene

Pathways & Interactions for PTCRA Gene

genes like me logo Genes that share pathways with PTCRA: view

Pathways by source for PTCRA Gene

SIGNOR curated interactions for PTCRA Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PTCRA Gene

None

Drugs & Compounds for PTCRA Gene

(2) Drugs for PTCRA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PTCRA: view

Transcripts for PTCRA Gene

Unigene Clusters for PTCRA Gene

Pre T-cell antigen receptor alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTCRA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - -
SP3: -
SP4: - -
SP5: - - - -

Relevant External Links for PTCRA Gene

GeneLoc Exon Structure for
PTCRA
ECgene alternative splicing isoforms for
PTCRA

Expression for PTCRA Gene

mRNA expression in normal human tissues for PTCRA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTCRA Gene

This gene is overexpressed in Whole Blood (x34.1) and Spleen (x8.4).

Protein differential expression in normal tissues from HIPED for PTCRA Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTCRA Gene



SOURCE GeneReport for Unigene cluster for PTCRA Gene Hs.169002

mRNA Expression by UniProt/SwissProt for PTCRA Gene

Q6ISU1-PTCRA_HUMAN
Tissue specificity: Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.
genes like me logo Genes that share expression patterns with PTCRA: view

Protein tissue co-expression partners for PTCRA Gene

- Elite partner

Primer Products

Orthologs for PTCRA Gene

This gene was present in the common ancestor of mammals.

Orthologs for PTCRA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTCRA 35
  • 85.78 (n)
  • 81.12 (a)
PTCRA 36
  • 53 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTCRA 35
  • 84.14 (n)
  • 81.38 (a)
PTCRA 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptcra 35
  • 81.35 (n)
  • 76.92 (a)
Ptcra 16
Ptcra 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTCRA 35
  • 98.7 (n)
  • 96.8 (a)
PTCRA 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptcra 35
  • 78.91 (n)
  • 72.88 (a)
Species with no ortholog for PTCRA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PTCRA Gene

ENSEMBL:
Gene Tree for PTCRA (if available)
TreeFam:
Gene Tree for PTCRA (if available)

Paralogs for PTCRA Gene

No data available for Paralogs for PTCRA Gene

Variants for PTCRA Gene

Sequence variations from dbSNP and Humsavar for PTCRA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs9471966 - 42,923,284(+) CTTTG(A/G)TCTGC intron-variant, reference, missense
rs36111725 - 42,925,383(+) CCCCC(A/G)CAACC reference, missense
rs6901007 -- 42,925,096(+) GGTAT(G/T)TATTA intron-variant
rs10948053 -- 42,924,757(+) cacga(A/G)gtcag intron-variant
rs11343543 -- 42,924,970(+) CATCT(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTCRA Gene

Variant ID Type Subtype PubMed ID
nsv830651 CNV Loss 17160897
esv1622905 CNV Insertion 17803354

Variation tolerance for PTCRA Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.99; 89.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PTCRA Gene

Disorders for PTCRA Gene

MalaCards: The human disease database

(28) MalaCards diseases for PTCRA Gene - From: DISEASES

Disorder Aliases PubMed IDs
granulomatous orchitis
  • non-specific granulomatous orchitis
shoulder impingement syndrome
  • impingement syndrome of shoulder region
choriocarcinoma of the testis
  • testicular choriocarcinoma
pancreatic serous cystadenoma
neurogenic bowel
- elite association - COSMIC cancer census association via MalaCards
Search PTCRA in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTCRA

Genetic Association Database (GAD)
PTCRA
Human Genome Epidemiology (HuGE) Navigator
PTCRA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTCRA
genes like me logo Genes that share disorders with PTCRA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTCRA Gene

Publications for PTCRA Gene

  1. Cloning and comparative analysis of the human pre-T-cell receptor alpha-chain gene. (PMID: 8618853) Del Porto P. … Saint-Ruf C. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 23 67
  2. Genomic structure of the human pre-T cell receptor alpha chain and expression of two mRNA isoforms. (PMID: 9842925) Saint-Ruf C. … von Boehmer H. (Eur. J. Immunol. 1998) 2 3 23
  3. Differential subcellular localization regulates c-Cbl E3 ligase activity upon Notch3 protein in T-cell leukemia. (PMID: 19966856) Checquolo S. … Screpanti I. (Oncogene 2010) 3 23
  4. Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. (PMID: 11891328) Bellavia D. … Screpanti I. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for PTCRA Gene

Sources for PTCRA Gene

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