Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PTCRA Gene

Aliases for PTCRA Gene

  • Pre T-Cell Antigen Receptor Alpha 2 3
  • PT-Alpha-TCR 3 4
  • PT-ALPHA 3 4
  • PTA 3 4
  • Pre-T-Cell Receptor Alpha Chain 3

External Ids for PTCRA Gene

Previous GeneCards Identifiers for PTCRA Gene

  • GC06P042885
  • GC06P042931
  • GC06P042932
  • GC06P042992
  • GC06P042883
  • GC06P042601

Summaries for PTCRA Gene

Entrez Gene Summary for PTCRA Gene

  • The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for PTCRA Gene

PTCRA (Pre T-Cell Antigen Receptor Alpha) is a Protein Coding gene. Diseases associated with PTCRA include granulomatous orchitis and neurogenic bowel. Among its related pathways are Transcriptional misregulation in cancer and C-MYB transcription factor network.

UniProtKB/Swiss-Prot for PTCRA Gene

  • The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTCRA Gene

Genomics for PTCRA Gene

Regulatory Elements for PTCRA Gene

Genomic Location for PTCRA Gene

Chromosome:
6
Start:
42,915,807 bp from pter
End:
42,925,838 bp from pter
Size:
10,032 bases
Orientation:
Plus strand

Genomic View for PTCRA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTCRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTCRA Gene

Proteins for PTCRA Gene

  • Protein details for PTCRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ISU1-PTCRA_HUMAN
    Recommended name:
    Pre T-cell antigen receptor alpha
    Protein Accession:
    Q6ISU1
    Secondary Accessions:
    • Q5TFZ7

    Protein attributes for PTCRA Gene

    Size:
    281 amino acids
    Molecular mass:
    29266 Da
    Quaternary structure:
    • Heterodimer with TCRB; disulfide linked. This heterodimer assembles with CD3 proteins into a signaling-competent pre-T-cell receptor complex. Interacts with RHBDD1.

    Three dimensional structures from OCA and Proteopedia for PTCRA Gene

    Alternative splice isoforms for PTCRA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTCRA Gene

Proteomics data for PTCRA Gene at MOPED

Post-translational modifications for PTCRA Gene

  • Glycosylation at Asn 67
  • Modification sites at PhosphoSitePlus

Other Protein References for PTCRA Gene

No data available for DME Specific Peptides for PTCRA Gene

Domains & Families for PTCRA Gene

Protein Domains for PTCRA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PTCRA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PTCRA: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PTCRA Gene

Function for PTCRA Gene

Molecular function for PTCRA Gene

GENATLAS Biochemistry:
pre-T-cell receptor alpha chain,invariant,heterodimerizing with TCRbeta chain receptor in immature thymocyte
UniProtKB/Swiss-Prot Function:
The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development.

Gene Ontology (GO) - Molecular Function for PTCRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22795130
genes like me logo Genes that share ontologies with PTCRA: view
genes like me logo Genes that share phenotypes with PTCRA: view

Animal Models for PTCRA Gene

MGI Knock Outs for PTCRA:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTCRA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PTCRA Gene

Localization for PTCRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTCRA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTCRA Gene COMPARTMENTS Subcellular localization image for PTCRA gene
Compartment Confidence
nucleus 2
plasma membrane 2
cytoskeleton 1
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for PTCRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PTCRA: view

Pathways & Interactions for PTCRA Gene

genes like me logo Genes that share pathways with PTCRA: view

Pathways by source for PTCRA Gene

PCR Array Products

SIGNOR curated interactions for PTCRA Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PTCRA Gene

None

Drugs & Compounds for PTCRA Gene

(2) Drugs for PTCRA Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Estradiol Approved, Investigational Pharma Sex hormone 1057
estrogen Pharma 0
genes like me logo Genes that share compounds with PTCRA: view

Transcripts for PTCRA Gene

Unigene Clusters for PTCRA Gene

Pre T-cell antigen receptor alpha:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTCRA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTCRA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - -
SP3: -
SP4: - -
SP5: - - - -

Relevant External Links for PTCRA Gene

GeneLoc Exon Structure for
PTCRA
ECgene alternative splicing isoforms for
PTCRA

Expression for PTCRA Gene

mRNA expression in normal human tissues for PTCRA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTCRA Gene

This gene is overexpressed in Whole Blood (x34.1) and Spleen (x8.4).

Protein differential expression in normal tissues from HIPED for PTCRA Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTCRA Gene



SOURCE GeneReport for Unigene cluster for PTCRA Gene Hs.169002

mRNA Expression by UniProt/SwissProt for PTCRA Gene

Q6ISU1-PTCRA_HUMAN
Tissue specificity: Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.
genes like me logo Genes that share expression patterns with PTCRA: view

Protein tissue co-expression partners for PTCRA Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for PTCRA Gene

This gene was present in the common ancestor of mammals.

Orthologs for PTCRA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTCRA 35
  • 85.78 (n)
  • 81.12 (a)
PTCRA 36
  • 53 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTCRA 35
  • 84.14 (n)
  • 81.38 (a)
PTCRA 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptcra 35
  • 81.35 (n)
  • 76.92 (a)
Ptcra 16
Ptcra 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTCRA 35
  • 98.7 (n)
  • 96.8 (a)
PTCRA 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptcra 35
  • 78.91 (n)
  • 72.88 (a)
Species with no ortholog for PTCRA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PTCRA Gene

ENSEMBL:
Gene Tree for PTCRA (if available)
TreeFam:
Gene Tree for PTCRA (if available)

Paralogs for PTCRA Gene

No data available for Paralogs for PTCRA Gene

Variants for PTCRA Gene

Sequence variations from dbSNP and Humsavar for PTCRA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1997554 -- 42,925,602(+) GATCT(C/G)GCCTC frameshift-variant
rs2235831 -- 42,916,173(-) GGCTT(C/G)GGCAG intron-variant
rs2235834 -- 42,923,467(-) CCAGA(C/G)GCTCT intron-variant
rs2235835 -- 42,923,423(-) GAGCC(C/T)GCCCT intron-variant
rs6901007 -- 42,925,096(+) GGTAT(G/T)TATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTCRA Gene

Variant ID Type Subtype PubMed ID
nsv830651 CNV Loss 17160897
esv1622905 CNV Insertion 17803354

Variation tolerance for PTCRA Gene

Residual Variation Intolerance Score: 74.94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.99; 89.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTCRA Gene

HapMap Linkage Disequilibrium report
PTCRA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTCRA Gene

Disorders for PTCRA Gene

MalaCards: The human disease database

(28) MalaCards diseases for PTCRA Gene - From: DISEASES

Disorder Aliases PubMed IDs
granulomatous orchitis
  • non-specific granulomatous orchitis
neurogenic bowel
choriocarcinoma of the testis
  • testicular choriocarcinoma
cavernous sinus thrombosis
  • thrombosis of cavernous venous sinus
cd3epsilon deficiency
- elite association
Search PTCRA in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTCRA

Genetic Association Database (GAD)
PTCRA
Human Genome Epidemiology (HuGE) Navigator
PTCRA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTCRA
genes like me logo Genes that share disorders with PTCRA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTCRA Gene

Publications for PTCRA Gene

  1. Genomic structure of the human pre-T cell receptor alpha chain and expression of two mRNA isoforms. (PMID: 9842925) Saint-Ruf C. … von Boehmer H. (Eur. J. Immunol. 1998) 2 23 67
  2. Cloning and comparative analysis of the human pre-T-cell receptor alpha-chain gene. (PMID: 8618853) Del Porto P. … Saint-Ruf C. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 23 67
  3. Differential subcellular localization regulates c-Cbl E3 ligase activity upon Notch3 protein in T-cell leukemia. (PMID: 19966856) Checquolo S. … Screpanti I. (Oncogene 2010) 23 67
  4. Pre T-cell receptor alpha (pTalpha) expression patterns and functional analysis in human T-cell lymphoblastic leukemia. (PMID: 20208138) Ivanyi P. … Franzke A. (Cell. Oncol. 2010) 23 67
  5. Immunohistochemical detection of prothymosin alpha in pituitary adenomas--a new marker of tumor recurrence? (PMID: 20430720) Pawlikowski M. … Winczyk K. (Folia Histochem. Cytobiol. 2009) 23 67

Products for PTCRA Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate PTCRA
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for PTCRA
    • Block miRNA regulation of PTCRA using miScript Target Protectors

    Sources for PTCRA Gene

    Back to Top

    Content