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Aliases for PTBP3 Gene

Aliases for PTBP3 Gene

  • Polypyrimidine Tract Binding Protein 3 2 3 5
  • Regulator Of Differentiation 1 3 4
  • ROD1 3 4
  • ROD1 Regulator Of Differentiation 1 (S. Pombe) 2
  • Regulator Of Differentiation (In S. Pombe) 1 2
  • Fission Yeast Differentiation Regulator 3
  • ROD1 Regulator Of Differentiation 1 3

External Ids for PTBP3 Gene

Previous HGNC Symbols for PTBP3 Gene

  • ROD1

Previous GeneCards Identifiers for PTBP3 Gene

  • GC09M114981

Summaries for PTBP3 Gene

Entrez Gene Summary for PTBP3 Gene

  • The protein encoded by this gene binds RNA and is a regulator of cell differentiation. The encoded protein preferentially binds to poly(G) and poly(U) sequences in vitro. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for PTBP3 Gene

PTBP3 (Polypyrimidine Tract Binding Protein 3) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ENSG00000268083.

UniProtKB/Swiss-Prot for PTBP3 Gene

  • RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTBP3 Gene

Genomics for PTBP3 Gene

Regulatory Elements for PTBP3 Gene

Enhancers for PTBP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTBP3 on UCSC Golden Path with GeneCards custom track

Promoters for PTBP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTBP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PTBP3 Gene

Chromosome:
9
Start:
112,217,715 bp from pter
End:
112,333,667 bp from pter
Size:
115,953 bases
Orientation:
Minus strand

Genomic View for PTBP3 Gene

Genes around PTBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTBP3 Gene

Proteins for PTBP3 Gene

  • Protein details for PTBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95758-PTBP3_HUMAN
    Recommended name:
    Polypyrimidine tract-binding protein 3
    Protein Accession:
    O95758
    Secondary Accessions:
    • B1ALY2
    • B1ALY3
    • B1ALY5
    • B1ALY6
    • B3KME7
    • Q68DB9
    • Q86YB3
    • Q86YH9

    Protein attributes for PTBP3 Gene

    Size:
    552 amino acids
    Molecular mass:
    59690 Da
    Quaternary structure:
    • Interacts with THBS4 (via the acidic amphipathic C-terminus).
    SequenceCaution:
    • Sequence=AAH39896.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA75466.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BI463123; Type=Frameshift; Positions=92; Evidence={ECO:0000305};

    Alternative splice isoforms for PTBP3 Gene

neXtProt entry for PTBP3 Gene

Proteomics data for PTBP3 Gene at MOPED

Post-translational modifications for PTBP3 Gene

  • Ubiquitination at Lys 106, Lys 400, Lys 418, Lys 472, and Lys 475
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for PTBP3 Gene

Domains & Families for PTBP3 Gene

Gene Families for PTBP3 Gene

Protein Domains for PTBP3 Gene

Suggested Antigen Peptide Sequences for PTBP3 Gene

Graphical View of Domain Structure for InterPro Entry

O95758

UniProtKB/Swiss-Prot:

PTBP3_HUMAN :
  • Contains 4 RRM (RNA recognition motif) domains.
Domain:
  • Contains 4 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with PTBP3: view

Function for PTBP3 Gene

Molecular function for PTBP3 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U).
genes like me logo Genes that share phenotypes with PTBP3: view

Animal Model Products

CRISPR Products

miRNA for PTBP3 Gene

miRTarBase miRNAs that target PTBP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTBP3 Gene

Localization for PTBP3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTBP3 Gene COMPARTMENTS Subcellular localization image for PTBP3 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PTBP3 Gene

Pathways & Interactions for PTBP3 Gene

SuperPathways for PTBP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PTBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033119 negative regulation of RNA splicing IDA 18335065
genes like me logo Genes that share ontologies with PTBP3: view

No data available for Pathways by source and SIGNOR curated interactions for PTBP3 Gene

Drugs & Compounds for PTBP3 Gene

(1) Additional Compounds for PTBP3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with PTBP3: view

Transcripts for PTBP3 Gene

Unigene Clusters for PTBP3 Gene

Polypyrimidine tract binding protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTBP3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - -
SP6: - -
SP7: - - - - - - - - -
SP8:
SP9:

ExUns: 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for PTBP3 Gene

GeneLoc Exon Structure for
PTBP3
ECgene alternative splicing isoforms for
PTBP3

Expression for PTBP3 Gene

mRNA expression in normal human tissues for PTBP3 Gene

mRNA differential expression in normal tissues according to GTEx for PTBP3 Gene

This gene is overexpressed in Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for PTBP3 Gene

This gene is overexpressed in CD8 Tcells (9.6), Lymph node (7.4), and Monocytes (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTBP3 Gene



SOURCE GeneReport for Unigene cluster for PTBP3 Gene Hs.269988

mRNA Expression by UniProt/SwissProt for PTBP3 Gene

O95758-PTBP3_HUMAN
Tissue specificity: Expressed in several hematopoietic cell lines examined.
genes like me logo Genes that share expression patterns with PTBP3: view

Protein tissue co-expression partners for PTBP3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PTBP3 Gene

Orthologs for PTBP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTBP3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PTBP3 35
  • 91.51 (n)
  • 92.08 (a)
PTBP3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptbp3 35
  • 91.53 (n)
  • 94.92 (a)
Ptbp3 16
Ptbp3 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ROD1 35
  • 99.82 (n)
  • 100 (a)
PTBP3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptbp3 35
  • 91.97 (n)
  • 95.22 (a)
cow
(Bos Taurus)
Mammalia PTBP3 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTBP3 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
chicken
(Gallus gallus)
Aves ROD1 35
  • 76.24 (n)
  • 71.29 (a)
PTBP3 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTBP3 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptbp3 35
  • 77.26 (n)
  • 86.71 (a)
Str.13021 35
zebrafish
(Danio rerio)
Actinopterygii ptbp3 35
  • 72.67 (n)
  • 81.99 (a)
ptbp3 36
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta heph 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ptb-1 36
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for PTBP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTBP3 Gene

ENSEMBL:
Gene Tree for PTBP3 (if available)
TreeFam:
Gene Tree for PTBP3 (if available)

Paralogs for PTBP3 Gene

Paralogs for PTBP3 Gene

(2) SIMAP similar genes for PTBP3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PTBP3: view

Variants for PTBP3 Gene

Sequence variations from dbSNP and Humsavar for PTBP3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs720861 -- 112,217,857(+) ATGAA(C/T)GCTAA utr-variant-3-prime
rs940592 -- 112,255,785(-) TGGGC(A/C)TAGAG intron-variant
rs940593 -- 112,255,380(-) aaata(C/T)atata intron-variant
rs943620 -- 112,231,228(+) CATCA(C/T)TGTAA intron-variant
rs943621 -- 112,231,510(+) TTAAA(A/G)CATGG intron-variant

Variation tolerance for PTBP3 Gene

Residual Variation Intolerance Score: 28.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTBP3 Gene

HapMap Linkage Disequilibrium report
PTBP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PTBP3 Gene

Disorders for PTBP3 Gene

Relevant External Links for PTBP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTBP3

No disorders were found for PTBP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTBP3 Gene

Publications for PTBP3 Gene

  1. Isolation of a mammalian homologue of a fission yeast differentiation regulator. (PMID: 10207106) Yamamoto H. … Okayama H. (Mol. Cell. Biol. 1999) 2 3 4 23 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. The effects of PTBP3 silencing on the proliferation and differentiation of MKN45 human gastric cancer cells. (PMID: 25119103) Chen B. … Liu J.W. (Life Sci. 2014) 3

Products for PTBP3 Gene

Sources for PTBP3 Gene

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