Aliases for PTBP2 Gene
External Ids for PTBP2 Gene
Previous GeneCards Identifiers for PTBP2 Gene
The protein encoded by this gene binds to intronic polypyrimidine clusters in pre-mRNA molecules and is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein (PTB) but most of its isoforms are expressed primarily in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for PTBP2 Gene
PTBP2 (Polypyrimidine Tract Binding Protein 2) is a Protein Coding gene. Diseases associated with PTBP2 include Cancer-Associated Retinopathy. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ENSG00000268083.
UniProtKB/Swiss-Prot for PTBP2 Gene
RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.