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Aliases for PTAFR Gene

Aliases for PTAFR Gene

  • Platelet-Activating Factor Receptor 2 3
  • PAF-R 3 4
  • PAFR 3 4

External Ids for PTAFR Gene

Previous GeneCards Identifiers for PTAFR Gene

  • GC01P026956
  • GC01M027486
  • GC01M027708
  • GC01M028080
  • GC01M028346
  • GC01M028473
  • GC01M026730

Summaries for PTAFR Gene

Entrez Gene Summary for PTAFR Gene

  • This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for PTAFR Gene

PTAFR (Platelet-Activating Factor Receptor) is a Protein Coding gene. Diseases associated with PTAFR include melanoma metastasis. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and lipopolysaccharide binding. An important paralog of this gene is P2RY2.

UniProtKB/Swiss-Prot for PTAFR Gene

  • Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.

Tocris Summary for PTAFR Gene

  • Platelet-activating factor receptor (PAF-R) is a Gq/G11-coupled-protein receptor that has a role in a wide range of biological processes such as vasodilation, superoxide formation, cell proliferation, angiogenesis and regulation of the inflammatory response.

Gene Wiki entry for PTAFR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTAFR Gene

Genomics for PTAFR Gene

Regulatory Elements for PTAFR Gene

Genomic Location for PTAFR Gene

Chromosome:
1
Start:
28,147,166 bp from pter
End:
28,193,936 bp from pter
Size:
46,771 bases
Orientation:
Minus strand

Genomic View for PTAFR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTAFR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTAFR Gene

Proteins for PTAFR Gene

  • Protein details for PTAFR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25105-PTAFR_HUMAN
    Recommended name:
    Platelet-activating factor receptor
    Protein Accession:
    P25105
    Secondary Accessions:
    • A3KMC8
    • A8K2H5

    Protein attributes for PTAFR Gene

    Size:
    342 amino acids
    Molecular mass:
    39203 Da
    Quaternary structure:
    • Interacts with ARRB1.

    Three dimensional structures from OCA and Proteopedia for PTAFR Gene

neXtProt entry for PTAFR Gene

Proteomics data for PTAFR Gene at MOPED

Post-translational modifications for PTAFR Gene

  • Glycosylation at Asn 169
  • Modification sites at PhosphoSitePlus

Other Protein References for PTAFR Gene

Antibody Products

No data available for DME Specific Peptides for PTAFR Gene

Domains & Families for PTAFR Gene

Gene Families for PTAFR Gene

Protein Domains for PTAFR Gene

Suggested Antigen Peptide Sequences for PTAFR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25105

UniProtKB/Swiss-Prot:

PTAFR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTAFR: view

Function for PTAFR Gene

Molecular function for PTAFR Gene

GENATLAS Biochemistry:
platelet activating factor,receptor,G protein coupled receptor superfamilu
UniProtKB/Swiss-Prot Function:
Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.
UniProtKB/Swiss-Prot Induction:
By CSF2/GM-CSF, IL5/interleukin-5 and n-butyrate.

Gene Ontology (GO) - Molecular Function for PTAFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IEA --
GO:0001875 lipopolysaccharide receptor activity IEA --
GO:0004930 G-protein coupled receptor activity TAS 1322356
GO:0004992 platelet activating factor receptor activity IDA 1281995
GO:0005543 phospholipid binding IDA 1656963
genes like me logo Genes that share ontologies with PTAFR: view
genes like me logo Genes that share phenotypes with PTAFR: view

Animal Models for PTAFR Gene

MGI Knock Outs for PTAFR:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTAFR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PTAFR Gene

Localization for PTAFR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTAFR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTAFR Gene COMPARTMENTS Subcellular localization image for PTAFR gene
Compartment Confidence
nucleus 4
plasma membrane 4
extracellular 1

Gene Ontology (GO) - Cellular Components for PTAFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8168510
GO:0016020 membrane IDA 1374385
GO:0016021 integral component of membrane NAS 1281995
genes like me logo Genes that share ontologies with PTAFR: view

Pathways & Interactions for PTAFR Gene

genes like me logo Genes that share pathways with PTAFR: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PTAFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA --
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response TAS 8892648
GO:0007186 G-protein coupled receptor signaling pathway IMP 1657923
genes like me logo Genes that share ontologies with PTAFR: view

No data available for SIGNOR curated interactions for PTAFR Gene

Drugs & Compounds for PTAFR Gene

(48) Drugs for PTAFR Gene - From: NovoSeek, IUPHAR, DGIdb, Tocris, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alprazolam Approved, Illicit, Investigational Pharma 64
Chloramphenicol Approved Pharma 6
Cyproheptadine Approved Pharma Antagonist 15
Etoposide Approved Pharma Topo II inhibitor, Topoisomerase 2 Inhibitors, Topoisomerase II inhibitor 1127
Indomethacin Approved, Investigational Pharma Inhibition, Inhibitor Cox inhibitor 97

(41) Additional Compounds for PTAFR Gene - From: NovoSeek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
52770 RP
Antagonist
SR 27417
Antagonist
Y-24180
Antagonist
PAF (C16)
74389-68-7
Actinomycin D
genes like me logo Genes that share compounds with PTAFR: view

Drug Products

Transcripts for PTAFR Gene

Unigene Clusters for PTAFR Gene

Platelet-activating factor receptor:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTAFR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTAFR Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: - -
SP3: -
SP4: - - -

Relevant External Links for PTAFR Gene

GeneLoc Exon Structure for
PTAFR
ECgene alternative splicing isoforms for
PTAFR

Expression for PTAFR Gene

mRNA expression in normal human tissues for PTAFR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTAFR Gene

This gene is overexpressed in Whole Blood (x30.8).

SOURCE GeneReport for Unigene cluster for PTAFR Gene Hs.77542

mRNA Expression by UniProt/SwissProt for PTAFR Gene

P25105-PTAFR_HUMAN
Tissue specificity: Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes.
genes like me logo Genes that share expression patterns with PTAFR: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PTAFR Gene

Orthologs for PTAFR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTAFR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTAFR 35
  • 87.29 (n)
  • 84.75 (a)
PTAFR 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTAFR 35
  • 87.22 (n)
  • 84.07 (a)
PTAFR 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptafr 35
  • 82.31 (n)
  • 81.82 (a)
Ptafr 16
Ptafr 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTAFR 35
  • 99.42 (n)
  • 99.12 (a)
PTAFR 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptafr 35
  • 82.5 (n)
  • 79.18 (a)
oppossum
(Monodelphis domestica)
Mammalia PTAFR 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTAFR 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTAFR 35
  • 66.99 (n)
  • 65.05 (a)
PTAFR 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTAFR 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptafr 35
  • 60.12 (n)
  • 60.42 (a)
Str.5217 35
African clawed frog
(Xenopus laevis)
Amphibia MGC52896 35
zebrafish
(Danio rerio)
Actinopterygii LOC100002627 35
  • 55.52 (n)
  • 48.41 (a)
PTAFR 36
  • 42 (a)
OneToOne
Species with no ortholog for PTAFR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTAFR Gene

ENSEMBL:
Gene Tree for PTAFR (if available)
TreeFam:
Gene Tree for PTAFR (if available)

Paralogs for PTAFR Gene

(20) SIMAP similar genes for PTAFR Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PTAFR: view

Variants for PTAFR Gene

Sequence variations from dbSNP and Humsavar for PTAFR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs5938 - 28,150,351(-) CAACG(A/C)TGAAG missense, reference
rs5939 - 28,150,009(-) TGGCA(A/G)TTCCC reference, missense
rs167523 -- 28,156,943(+) GTCCG(C/T)ACCTC intron-variant
rs61549489 -- 28,159,604(+) AGGCC(A/G)AGGCA intron-variant
rs61162988 -- 28,185,708(+) AAAAG(-/G)TTACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTAFR Gene

Variant ID Type Subtype PubMed ID
nsv871151 CNV Gain 21882294
esv2678105 CNV Deletion 23128226
nsv7546 CNV Loss 18451855

Variation tolerance for PTAFR Gene

Residual Variation Intolerance Score: 51.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTAFR Gene

HapMap Linkage Disequilibrium report
PTAFR
Human Gene Mutation Database (HGMD)
PTAFR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTAFR Gene

Disorders for PTAFR Gene

MalaCards: The human disease database

(1) MalaCards diseases for PTAFR Gene - From: GeneCards

Disorder Aliases PubMed IDs
melanoma metastasis
- elite association
Search PTAFR in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTAFR

Genetic Association Database (GAD)
PTAFR
Human Genome Epidemiology (HuGE) Navigator
PTAFR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTAFR
genes like me logo Genes that share disorders with PTAFR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTAFR Gene

Publications for PTAFR Gene

  1. The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1. (PMID: 1322356) Seyfried C.E. … Gray P.W. (Genomics 1992) 2 23 67
  2. Epidermal platelet-activating factor receptor activation and ultraviolet B radiation result in synergistic tumor necrosis factor-alpha production. (PMID: 19769579) Wolverton J.E. … Travers J.B. (Photochem. Photobiol. 2010) 23 67
  3. Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor. (PMID: 20007715) Hirota N. … Nakamura M. (J. Biol. Chem. 2010) 23 67
  4. Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor. (PMID: 20421642) Dyer K.D. … Rosenberg H.F. (J. Immunol. 2010) 23 67
  5. Ultraviolet B radiation generated platelet-activating factor receptor agonist formation involves EGF-R-mediated reactive oxygen species. (PMID: 19234179) Yao Y. … Travers J.B. (J. Immunol. 2009) 23 67

Products for PTAFR Gene

Sources for PTAFR Gene

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