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Aliases for PTAFR Gene

Aliases for PTAFR Gene

  • Platelet-Activating Factor Receptor 2 3
  • PAF-R 3 4
  • PAFR 3 4

External Ids for PTAFR Gene

Summaries for PTAFR Gene

Entrez Gene Summary for PTAFR Gene

  • This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for PTAFR Gene

PTAFR (Platelet-Activating Factor Receptor) is a Protein Coding gene. Diseases associated with PTAFR include melanoma metastasis and lymphoid leukemia. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and lipopolysaccharide binding. An important paralog of this gene is P2RY2.

UniProtKB/Swiss-Prot for PTAFR Gene

  • Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.

Tocris Summary for PTAFR Gene

  • Platelet-activating factor receptor (PAF-R) is a Gq/G11-coupled-protein receptor that has a role in a wide range of biological processes such as vasodilation, superoxide formation, cell proliferation, angiogenesis and regulation of the inflammatory response. PAF-R is linked to multiple intracellular signaling pathways, including the p38 MAPK and PI 3-K pathways, through increasing intracellular calcium mobilization, increasing IP3 synthesis and decreasing cAMP formation. PAF-R has a wide biological distribution with high expression levels in the spleen and skeletal muscles and lower concentrations in the small intestine, lung, heart and liver. The human gene encoding the PAF-R is located on chromosome 1p35-34.3.

Gene Wiki entry for PTAFR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTAFR Gene

Genomics for PTAFR Gene

Genomic Location for PTAFR Gene

Start:
28,147,166 bp from pter
End:
28,193,936 bp from pter
Size:
46,771 bases
Orientation:
Minus strand

Genomic View for PTAFR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTAFR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTAFR Gene

Regulatory Elements for PTAFR Gene

Proteins for PTAFR Gene

  • Protein details for PTAFR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25105-PTAFR_HUMAN
    Recommended name:
    Platelet-activating factor receptor
    Protein Accession:
    P25105
    Secondary Accessions:
    • A3KMC8
    • A8K2H5

    Protein attributes for PTAFR Gene

    Size:
    342 amino acids
    Molecular mass:
    39203 Da
    Quaternary structure:
    • Interacts with ARRB1.

    Three dimensional structures from OCA and Proteopedia for PTAFR Gene

neXtProt entry for PTAFR Gene

Proteomics data for PTAFR Gene at MOPED

Post-translational modifications for PTAFR Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn169

Other Protein References for PTAFR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PTAFR Gene

Domains for PTAFR Gene

Gene Families for PTAFR Gene

HGNC:
  • PTAFR :GPCR / Class A : Platelet-activating factor receptors
IUPHAR :

Protein Domains for PTAFR Gene

UniProtKB/Swiss-Prot:

PTAFR_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P25105
genes like me logo Genes that share domains with PTAFR: view

Function for PTAFR Gene

Molecular function for PTAFR Gene

GENATLAS Biochemistry: platelet activating factor,receptor,G protein coupled receptor superfamilu
UniProtKB/Swiss-Prot Function: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.
UniProtKB/Swiss-Prot Induction: By CSF2/GM-CSF, IL5/interleukin-5 and n-butyrate.

Gene Ontology (GO) - Molecular Function for PTAFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IEA --
GO:0001875 lipopolysaccharide receptor activity IEA --
GO:0004930 G-protein coupled receptor activity TAS 1322356
GO:0004992 platelet activating factor receptor activity IDA 1281995
GO:0005543 phospholipid binding IDA 1656963
genes like me logo Genes that share ontologies with PTAFR: view
genes like me logo Genes that share phenotypes with PTAFR: view

Animal Models for PTAFR Gene

MGI Knock Outs for PTAFR:

miRNA for PTAFR Gene

miRTarBase miRNAs that target PTAFR

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PTAFR Gene

Localization for PTAFR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTAFR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTAFR Gene COMPARTMENTS Subcellular localization image for PTAFR gene
Compartment Confidence
plasma membrane 5
nucleus 4
extracellular 2

Gene Ontology (GO) - Cellular Components for PTAFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8168510
GO:0016020 membrane IDA 1374385
GO:0016021 integral component of membrane NAS 1281995
genes like me logo Genes that share ontologies with PTAFR: view

Pathways for PTAFR Gene

genes like me logo Genes that share pathways with PTAFR: view

Gene Ontology (GO) - Biological Process for PTAFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA --
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response TAS 8892648
GO:0007186 G-protein coupled receptor signaling pathway IMP 1657923
genes like me logo Genes that share ontologies with PTAFR: view

Compounds for PTAFR Gene

(4) Tocris Compounds for PTAFR Gene

Compound Action Cas Number
Ginkgolide B PAF receptor antagonist [15291-77-7]
PAF (C16) Endogenous platelet-activating factor (PAF) [74389-68-7]
PCA 4248 PAF receptor antagonist [123875-01-4]
WEB 2086 Potent PAF receptor antagonist [105219-56-5]

(1) HMDB Compounds for PTAFR Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(21) IUPHAR Ligand for PTAFR Gene

Ligand Type Action Affinity Pubmed IDs
SR 27417 Antagonist Antagonist 10.3
ABT-299 Antagonist Antagonist 9.5
ABT-491 Antagonist Antagonist 9.2
Y-24180 Antagonist Antagonist 9
[3H]PAF Agonist Full agonist 8.9
[3H]52770 RP Antagonist Antagonist 8.4
CV-6209 Antagonist Antagonist 8.3
52770 RP Antagonist Antagonist 8.2
[3H]apafant Antagonist Antagonist 8
PAF Agonist Full agonist 7.9
2-O-ethyl-PAF C-16 Agonist Full agonist 7.7
apafant Antagonist Antagonist 7.5
SDZ 64-412 Antagonist Antagonist 7.2
BN 50739 Antagonist Antagonist 6.9
CV-3988 Antagonist Antagonist 6.8
bepafant Antagonist Antagonist 6.49
SCH 37370 Antagonist Antagonist 6.2
SCH 40338 Antagonist Antagonist 6.2
2-O-methyl-PAF C-18 Agonist Full agonist 5.8
PCA 4248 Antagonist Antagonist 5.44
enantio PAF C-16 Agonist Full agonist 5

(63) Novoseek inferred chemical compound relationships for PTAFR Gene

Compound -log(P) Hits PubMed IDs
web2086 85.1 8
ginkgolide b 81 13
lexipafant 76.9 5
cpaf 75.6 1
cv 3988 75.2 2
genes like me logo Genes that share compounds with PTAFR: view

Transcripts for PTAFR Gene

Unigene Clusters for PTAFR Gene

Platelet-activating factor receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTAFR Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: - -
SP3: -
SP4: - - -

Relevant External Links for PTAFR Gene

GeneLoc Exon Structure for
PTAFR
ECgene alternative splicing isoforms for
PTAFR

Expression for PTAFR Gene

mRNA expression in normal human tissues for PTAFR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTAFR Gene

This gene is overexpressed in Whole Blood (30.8).

SOURCE GeneReport for Unigene cluster for PTAFR Gene Hs.77542

mRNA Expression by UniProt/SwissProt for PTAFR Gene

P25105-PTAFR_HUMAN
Tissue specificity: Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes.
genes like me logo Genes that share expressions with PTAFR: view

Orthologs for PTAFR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTAFR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTAFR 36
  • 99.42 (n)
  • 99.12 (a)
PTAFR 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTAFR 36
  • 87.29 (n)
  • 84.75 (a)
PTAFR 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTAFR 36
  • 87.22 (n)
  • 84.07 (a)
PTAFR 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptafr 36
  • 82.31 (n)
  • 81.82 (a)
Ptafr 16
Ptafr 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTAFR 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTAFR 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptafr 36
  • 82.5 (n)
  • 79.18 (a)
chicken
(Gallus gallus)
Aves PTAFR 36
  • 66.99 (n)
  • 65.05 (a)
PTAFR 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTAFR 37
  • 56 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52896 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ptafr 36
  • 60.12 (n)
  • 60.42 (a)
Str.5217 36
zebrafish
(Danio rerio)
Actinopterygii LOC100002627 36
  • 55.52 (n)
  • 48.41 (a)
PTAFR 37
  • 42 (a)
OneToOne
Species with no ortholog for PTAFR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTAFR Gene

ENSEMBL:
Gene Tree for PTAFR (if available)
TreeFam:
Gene Tree for PTAFR (if available)

Paralogs for PTAFR Gene

Selected SIMAP similar genes for PTAFR Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PTAFR: view

Variants for PTAFR Gene

Sequence variations from dbSNP and Humsavar for PTAFR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs5938 - 28,150,351(-) CAACG(A/C)TGAAG missense, reference
rs5939 - 28,150,009(-) TGGCA(A/G)TTCCC reference, missense
rs167523 -- 28,156,943(+) GTCCG(C/T)ACCTC intron-variant
rs167524 -- 28,168,146(+) ttttg(G/T)atttt intron-variant
rs184331 -- 28,163,966(-) CCCAG(A/C)TGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTAFR Gene

Variant ID Type Subtype PubMed ID
nsv871151 CNV Gain 21882294
esv2678105 CNV Deletion 23128226
nsv7546 CNV Loss 18451855

Relevant External Links for PTAFR Gene

HapMap Linkage Disequilibrium report
PTAFR
Human Gene Mutation Database (HGMD)
PTAFR

Disorders for PTAFR Gene

(28) Novoseek inferred disease relationships for PTAFR Gene

Disease -log(P) Hits PubMed IDs
hematoma subdural chronic 42.8 3
pneumococcal infections 38.7 3
inflammation 33.7 2
asthma allergic 23.7 2
necrosis 18.8 8

Relevant External Links for PTAFR

Genetic Association Database (GAD)
PTAFR
Human Genome Epidemiology (HuGE) Navigator
PTAFR
genes like me logo Genes that share disorders with PTAFR: view

No data available for UniProtKB/Swiss-Prot for PTAFR Gene

Publications for PTAFR Gene

  1. The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1. (PMID: 1322356) Seyfried C.E. … Gray P.W. (Genomics 1992) 2 3 4 23
  2. Platelet-activating factor receptor gene polymorphism in Japanese patients with multiple sclerosis. (PMID: 15748960) Osoegawa M. … Kira J. (J. Neuroimmunol. 2005) 3 23 49
  3. Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation. (PMID: 16709866) McLaughlin N.J. … Silliman C.C. (J. Immunol. 2006) 3 4 23
  4. Expression of a splice variant of the platelet-activating factor receptor transcript 2 in various human cancer cell lines. (PMID: 12467527) Youlyouz I. … Denizot Y. (Mediators Inflamm. 2002) 3 23
  5. The epidermal platelet-activating factor receptor augments chemotherapy-induced apoptosis in human carcinoma cell lines. (PMID: 12601006) Li T. … Travers J.B. (J. Biol. Chem. 2003) 3 23

Products for PTAFR Gene

Sources for PTAFR Gene

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