PSTPIP2 Gene

Aliases
for PSTPIP2 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Previous GC identifers: GC18M043875 GC18M043350 GC18M043451 GC18M041815 GC18M041817 GC18M040420

Summaries
for PSTPIP2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Genomic Views
for PSTPIP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000018.9  NC_018929.2  NT_010966.15  

SwitchGear Promoter luciferase reporter plasmid: PSTPIP2 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSTPIP2

PSTPIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M043563:  view genomic region     (about GC identifiers)

Proteins
for PSTPIP2 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

Explore the universe of human proteins at neXtProt for PSTPIP2: NX_Q9H939

Explore proteomics data for PSTPIP2 at MOPED

Post-translational modifications: 

PSTPIP2 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for PSTPIP2 OriGene Custom MassSpec OriGene Custom Protein Services for PSTPIP2
	GenScript Custom Purified and Recombinant Proteins Services for PSTPIP2
	Novus Biologicals PSTPIP2 Protein Novus Biologicals PSTPIP2 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for PSTPIP2
	Search eBioscience for Proteins for PSTPIP2
	Search GeneTex for Proteins for PSTPIP2
	antibodies-online proteins for PSTPIP2 (5 products)
	antibodies-online peptides for PSTPIP2

PSTPIP2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for PSTPIP2
	Novus Biologicals PSTPIP2 Antibodies
	Abcam antibodies for PSTPIP2
	Cloud-Clone Corp. Antibodies for PSTPIP2
	ThermoFisher Antibodies for PSTPIP2
	antibodies-online antibodies for PSTPIP2 (8 products)

PSTPIP2 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for PSTPIP2
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PSTPIP2
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for PSTPIP2 Cloud-Clone Corp. CLIAs for PSTPIP2
	Search eBioscience for ELISAs for PSTPIP2
	antibodies-online kits for PSTPIP2 (4 products)

Domains /
Families
for PSTPIP2 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

ProtoNet protein and cluster: Q9H939

Find genes that share domains with PSTPIP2           About GenesLikeMe

Function
for PSTPIP2 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

     Gene Ontology (GO): 1 molecular function term:    About this table

(inferred from 3 alleles) (MGI details for Pstpip2)

genOway: Develop your customized and physiologically relevant rodent model for PSTPIP2

miRNA Products:		miRTarBase miRNAs that target PSTPIP2: hsa-mir-26b-5p (MIRT029008), hsa-mir-24-3p (MIRT030448)
		Block miRNA regulation of human, mouse, rat PSTPIP2 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate PSTPIP2 (see all 41):
		hsa-miR-3607-3p hsa-miR-605 hsa-miR-298 hsa-miR-520g hsa-miR-509-3-5p hsa-miR-3163 hsa-miR-4324 hsa-miR-548am
		SwitchGear 3'UTR luciferase reporter plasmid: PSTPIP2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for PSTPIP2
		Predesigned siRNA for gene silencing in human, mouse, rat PSTPIP2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for PSTPIP2

Clone Products:		OriGene clones in human, mouse for PSTPIP2 (see all 7) OriGene ORF clones in mouse, rat for PSTPIP2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PSTPIP2 (NM_024430)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSTPIP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSTPIP2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PSTPIP2
		Browse ESI BIO Cell Lines and PureStem Progenitors for PSTPIP2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSTPIP2

Localization
for PSTPIP2 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytoskeleton	2
cytosol	2
nucleus	2
mitochondrion	1
plasma membrane	1

About this image

Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for PSTPIP2 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Drugs & Compounds
for PSTPIP2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Transcripts
for PSTPIP2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

Expression
for PSTPIP2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PSTPIP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ACAGGAAACT

About this image

Brain (Nervous System)    fully expand to see all 4 entries
Cerebral Cortex
Bone (Muscoskeletal System)
Bone Marrow
Yolk Sac (Extraembryonic Tissues)
Definitive Hematopoietic Stem Cells Definitive Yolk Sac
Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast
Ovary (Reproductive System)
Oviduct

Primer Products:		OriGene qPCR primer pairs and template standards for PSTPIP2 OriGene qSTAR qPCR primer pairs in human, mouse for PSTPIP2
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PSTPIP2
		QuantiTect SYBR Green Assays in human, mouse, rat PSTPIP2
		QuantiFast Probe-based Assays in human, mouse, rat PSTPIP2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSTPIP2

Orthologs
for PSTPIP2 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

Paralogs
for PSTPIP2 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for PSTPIP2 gene

PSTPIP1²  

2 SIMAP similar genes for PSTPIP2 using alignment to 1 protein entry:     PPIP2_HUMAN:

PSTPIP1    FCHO2

Find genes that share paralogs with PSTPIP2           About GenesLikeMe

Genomic Variants
for PSTPIP2 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Selected SNPs for PSTPIP2 (see all 1908)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs9202951,2	C,F,A,H	--	43563022(-)	AACGAG/ATACAT	1	--	int1		26		NS EA NA WA	2584
rs1829007281,2		--	43563106(+)	ACTAAC/TTCTTT	1	--	int1		0	--	--	--	--
rs1425097381,2	C	--	43563150(+)	ACAGCA/GGGAAA	1	--	int1		0	--	--	--	--
rs1872442381,2		--	43563216(+)	GCTTTA/GAACAA	1	--	int1		0	--	--	--	--
rs1460053131,2		--	43563219(+)	TTGAAC/TAATTA	1	--	int1		0	--	--	--	--
rs1169409641,2	C,F	--	43563236(+)	AGGGTG/AAATCA	1	--	int1		1		NA	120
rs1384233151,2		--	43563317(+)	ATGGTA/GTCTCG	1	--	int1		0	--	--	--	--
rs1478306681,2	C	--	43563331(+)	GGAAG-/TTAACA	1	--	int1		0	--	--	--	--
rs1918618311,2		--	43563335(+)	AGTAAC/TACTGC	1	--	int1		0	--	--	--	--
rs9202941,2	C,F,A,H	--	43563352(-)	TCCTTC/TAGAGG	1	--	int1		20		NS EA NA WA CSA	1023

HapMap Linkage Disequilibrium report for PSTPIP2 (43563502 - 43652250 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for PSTPIP2:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2717027	CNV	Deletion	23290073
esv2717030	CNV	Deletion	23290073
nsv2277	CNV	Loss	18451855

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing PSTPIP2

DNA2.0 Custom Variant and Variant Library Synthesis for PSTPIP2

Disorders / Diseases
for PSTPIP2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

Publications
for PSTPIP2 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PSTPIP2 gene, integrated from 10 sources (see all 16): (articles sorted by number of sources associating them with PSTPIP2)

Utopia: connect your pdf to the dynamic world of online information

1. Genetic susceptibility factors in a cohort of 38 patients with SAPHO syndrome: a study of PSTPIP2, NOD2, and LPIN2 genes. (PubMed id 20032092)^{1, 4} Hurtado-Nedelec M....GAcrard B. (J. Rheumatol. 2010)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
4. PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase. (PubMed id 9804817)^{1, 3} Wu Y....Lasky L.A. (J. Biol. Chem. 1998)
5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)¹ Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
6. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
7. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PubMed id 21706016)¹ Bisson N....Pawson T. (Nat. Biotechnol. 2011)
8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (Mol. Cell 2011)
9. Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)¹ Brehme M....Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009)
10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (Genome Res. 2006)

External Searches for PSTPIP2 gene

Genome Databases showing PSTPIP2 gene

Other Databases showing PSTPIP2 gene

Specialized Databases showing PSTPIP2 gene

Products
for PSTPIP2 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section