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PSTPIP2 Gene

protein-coding   GIFtS: 52
GCID: GC18M043563

Proline-Serine-Threonine Phosphatase Interacting Protein...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proline-Serine-Threonine Phosphatase Interacting Protein 21 2
PEST Phosphatase-Interacting Protein 22 3
MAYP2
Proline-Serine-Threonine Phosphatase-Interacting Protein 22

External Ids:    HGNC: 95811   Entrez Gene: 90502   Ensembl: ENSG000001522297   UniProtKB: Q9H9393   

Export aliases for PSTPIP2 gene to outside databases

Previous GC identifers: GC18M043875 GC18M043350 GC18M043451 GC18M041815 GC18M041817 GC18M040420


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PSTPIP2 Gene:
PSTPIP2 (proline-serine-threonine phosphatase interacting protein 2) is a protein-coding gene. Diseases associated with PSTPIP2 include sapho syndrome, and mast-cell leukemia. An important paralog of this gene is PSTPIP1.

UniProtKB/Swiss-Prot: PPIP2_HUMAN, Q9H939
Function: Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity)

Gene Wiki entry for PSTPIP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the PSTPIP2 gene promoter:
         Max1   CUTL1   NF-kappaB   POU3F2   HEN1   CREB   deltaCREB   Pax-4a   NF-kappaB1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSTPIP2 promoter sequence
   Search Chromatin IP Primers for PSTPIP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSTPIP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12   Ensembl cytogenetic band:  18q21.1   HGNC cytogenetic band: 18q12

PSTPIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSTPIP2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M043563:  view genomic region     (about GC identifiers)

Start:
43,563,502 bp from pter      End:
43,652,250 bp from pter
Size:
88,749 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PPIP2_HUMAN, Q9H939 (See protein sequence)
Recommended Name: Proline-serine-threonine phosphatase-interacting protein 2  
Size: 334 amino acids; 38858 Da
Sequence caution: Sequence=BAB14404.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Alternative splicing: 2 isoforms:  Q9H939-1   Q9H939-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PSTPIP2: NX_Q9H939

Explore proteomics data for PSTPIP2 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PSTPIP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_077748.3  
    ENSEMBL proteins: 
     ENSP00000468622   ENSP00000387261  

    PSTPIP2 Human Recombinant Protein Products:

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    Novus Biologicals PSTPIP2 Protein
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    Cloud-Clone Corp. Proteins for PSTPIP2

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    Search LSBio for Antibodies for PSTPIP2

    PSTPIP2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for PSTPIP2
    Cloud-Clone Corp. CLIAs for PSTPIP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001060 FCH_dom

    Graphical View of Domain Structure for InterPro Entry Q9H939

    ProtoNet protein and cluster: Q9H939

    1 Blocks protein domain: IPB001060 Cdc15/Fes/CIP4

    UniProtKB/Swiss-Prot: PPIP2_HUMAN, Q9H939
    Similarity: Contains 1 FCH domain


    PSTPIP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPIP2_HUMAN, Q9H939
    Function: Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    PSTPIP2 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for PSTPIP2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Increased cell death HMECs cel 
     Increased mitotic index 

         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Pstpip2):
     behavior/neurological  cellular  craniofacial  hearing/vestibular/ear  hematopoietic system 
     immune system  integument  limbs/digits/tail  mortality/aging  nervous system 
     skeleton 

    PSTPIP2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PSTPIP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PSTPIP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PSTPIP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PSTPIP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target PSTPIP2:
    hsa-mir-26b-5p (MIRT029008), hsa-mir-24-3p (MIRT030448)

    Block miRNA regulation of human, mouse, rat PSTPIP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PSTPIP2 (see all 41):
    hsa-miR-3607-3p hsa-miR-605 hsa-miR-298 hsa-miR-520g hsa-miR-509-3-5p hsa-miR-3163 hsa-miR-4324 hsa-miR-548am
    SwitchGear 3'UTR luciferase reporter plasmidPSTPIP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PSTPIP2
    Predesigned siRNA for gene silencing in human, mouse, rat PSTPIP2

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for PSTPIP2 (see all 7)
    OriGene ORF clones in mouse, rat for PSTPIP2
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    GenScript: all cDNA clones in your preferred vector: PSTPIP2 (NM_024430)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSTPIP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSTPIP2

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSTPIP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPIP2_HUMAN, Q9H939: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton2
    cytosol2
    nucleus2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--
    GO:0005856cytoskeleton IEA--
    GO:0016020membrane IEA--

    PSTPIP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PSTPIP2
    Interactions:

        GeneGlobe Interaction Network for PSTPIP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PSTPIP2 (Q9H9392, 3 ENSP000003872614) via UniProtKB, MINT, STRING, and/or I2D (see all 609)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SHC1P293532, 3, ENSP000004013034MINT-7947479 I2D: score=2 STRING: ENSP00000401303
    SHBGP042783, ENSP000003698164I2D: score=2 STRING: ENSP00000369816
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    PTPN12Q052093, ENSP000002485944I2D: score=1 STRING: ENSP00000248594
    PTPN18Q999523, ENSP000001757564I2D: score=1 STRING: ENSP00000175756
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PSTPIP2 (PPIP2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PSTPIP2 gene: 
    NM_024430.3  

    Unigene Cluster for PSTPIP2:

    Proline-serine-threonine phosphatase interacting protein 2
    Hs.567384  [show with all ESTs]
    Unigene Representative Sequence: NM_024430
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589328 ENST00000409746(uc002lbp.4 uc002lbq.4) ENST00000588801
    ENST00000593086 ENST00000591729 ENST00000587042
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PSTPIP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PSTPIP2 (see all 41):
    hsa-miR-3607-3p hsa-miR-605 hsa-miR-298 hsa-miR-520g hsa-miR-509-3-5p hsa-miR-3163 hsa-miR-4324 hsa-miR-548am
    SwitchGear 3'UTR luciferase reporter plasmidPSTPIP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PSTPIP2
    Predesigned siRNA for gene silencing in human, mouse, rat PSTPIP2
    Clone
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    OriGene clones in human, mouse for PSTPIP2 (see all 7)
    OriGene ORF clones in mouse, rat for PSTPIP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PSTPIP2 (NM_024430)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSTPIP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSTPIP2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PSTPIP2
    OriGene qSTAR qPCR primer pairs in human, mouse for PSTPIP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PSTPIP2
      QuantiTect SYBR Green Assays in human, mouse, rat PSTPIP2
      QuantiFast Probe-based Assays in human, mouse, rat PSTPIP2

    Additional mRNA sequence: 

    AK023100.1 BC026223.1 BC035395.1 

    6 DOTS entries:

    DT.102827746  DT.95264191  DT.97837155  DT.91758285  DT.95264190  DT.97767136 

    Selected AceView cDNA sequences (see all 46):

    NM_024430 BP337840 BQ900279 AI287478 BC026223 CN480871 BP352927 BQ072349 
    AW339515 BC035395 AI383965 CD365567 AW299396 BG058613 AU152596 BQ334394 
    AL600767 BX113330 BU193451 W89114 AU151412 AA082133 AK023100 BP357939 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PSTPIP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGGAAACT
    PSTPIP2 Expression
    About this image


    PSTPIP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
    PSTPIP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PSTPIP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567384
        Custom PCR Arrays for PSTPIP2
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat PSTPIP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSTPIP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PSTPIP2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pstpip21 , 5 proline-serine-threonine phosphatase-interacting protein more1, 5 85.33(n)1
    87.43(a)1
      18 (52.38 cM)5
    192011  NM_013831.41  NP_038859.31 
     777945455 
    chicken
    (Gallus gallus)
    Aves PSTPIP21 proline-serine-threonine phosphatase interacting protein more 69.26(n)
    68.56(a)
      770399  XM_001233736.2  XP_001233737.1 
    lizard
    (Anolis carolinensis)
    Reptilia PSTPIP26
    proline-serine-threonine phosphatase interacting p...
    72(a)
    1 ↔ 1
    1(35108646-35164695)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pstpip21 proline-serine-threonine phosphatase interacting protein more 65.03(n)
    62.32(a)
      100135727  XM_002936514.2  XP_002936560.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-251f6.41 si:ch211-251f6.4 61.87(n)
    60.54(a)
      100537857  XM_003199296.2  XP_003199344.2 


    ENSEMBL Gene Tree for PSTPIP2 (if available)
    TreeFam Gene Tree for PSTPIP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PSTPIP2 gene
    PSTPIP12  
    2 SIMAP similar genes for PSTPIP2 using alignment to 1 protein entry:     PPIP2_HUMAN:
    PSTPIP1    FCHO2

    PSTPIP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PSTPIP2 (see all 1908)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs9202951,2
    C,F,A,H--43563022(-) AACGAG/ATACAT 1 -- int126Minor allele frequency- A:0.23NS EA NA WA 2584
    rs1829007281,2
    --43563106(+) ACTAAC/TTCTTT 1 -- int10--------
    rs1425097381,2
    C--43563150(+) ACAGCA/GGGAAA 1 -- int10--------
    rs1872442381,2
    --43563216(+) GCTTTA/GAACAA 1 -- int10--------
    rs1460053131,2
    --43563219(+) TTGAAC/TAATTA 1 -- int10--------
    rs1169409641,2
    C,F--43563236(+) AGGGTG/AAATCA 1 -- int11Minor allele frequency- A:0.02NA 120
    rs1384233151,2
    --43563317(+) ATGGTA/GTCTCG 1 -- int10--------
    rs1478306681,2
    C--43563331(+) GGAAG-/TTAACA 1 -- int10--------
    rs1918618311,2
    --43563335(+) AGTAAC/TACTGC 1 -- int10--------
    rs9202941,2
    C,F,A,H--43563352(-) TCCTTC/TAGAGG 1 -- int120Minor allele frequency- T:0.35NS EA NA WA CSA 1023

    HapMap Linkage Disequilibrium report for PSTPIP2 (43563502 - 43652250 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PSTPIP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717027CNV Deletion23290073
    esv2717030CNV Deletion23290073
    nsv2277CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PSTPIP2
    DNA2.0 Custom Variant and Variant Library Synthesis for PSTPIP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    13 diseases for PSTPIP2:    
    About MalaCards
    sapho syndrome    mast-cell leukemia    cherubism    pyoderma
    pyoderma gangrenosum    osteomyelitis    t-cell leukemia    tonsillitis
    leukemia    thyroiditis    cerebritis    prostatitis
    endotheliitis

    3 diseases from the University of Copenhagen DISEASES database for PSTPIP2:
    Osteomyelitis     SAPHO syndrome     mast-cell leukemia

    PSTPIP2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PSTPIP2
    Human Genome Epidemiology (HuGE) Navigator: PSTPIP2 (1 document)

    Export disorders for PSTPIP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PSTPIP2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with PSTPIP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic susceptibility factors in a cohort of 38 patients with SAPHO syndrome: a study of PSTPIP2, NOD2, and LPIN2 genes. (PubMed id 20032092)1, 4 Hurtado-Nedelec M....GAcrard B. (J. Rheumatol. 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase. (PubMed id 9804817)1, 3 Wu Y....Lasky L.A. (J. Biol. Chem. 1998)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PubMed id 21706016)1 Bisson N....Pawson T. (Nat. Biotechnol. 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9050 HGNC: 9581 AceView: PSTPIP2 Ensembl:ENSG00000152229 euGenes: HUgn9050
    ECgene: PSTPIP2 H-InvDB: PSTPIP2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PSTPIP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PSTPIP2 gene:
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    GeneCards and IP:
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