Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PSTPIP2 Gene

protein-coding GIFtS: 53
GCID: GC18M043563

Proline-Serine-Threonine Phosphatase Interacting Protein...

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Proline-Serine-Threonine Phosphatase Interacting Protein 2¹ ²
PEST Phosphatase-Interacting Protein 2² ³
MAYP²
Proline-Serine-Threonine Phosphatase-Interacting Protein 2²

External Ids:	HGNC: 9581¹	Entrez Gene: 9050²	Ensembl: ENSG00000152229⁷	UniProtKB: Q9H939³

Export aliases for PSTPIP2 gene to outside databases

Previous GC identifers: GC18M043875 GC18M043350 GC18M043451 GC18M041815 GC18M041817 GC18M040420

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PSTPIP2 Gene:

PSTPIP2 (proline-serine-threonine phosphatase interacting protein 2) is a protein-coding gene. Diseases associated with PSTPIP2 include sapho syndrome, and mast-cell leukemia. An important paralog of this gene is PSTPIP1.

UniProtKB/Swiss-Prot: PPIP2_HUMAN, Q9H939

Function: Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity)

Gene Wiki entry for PSTPIP2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NT_010966.14 NC_018929.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PSTPIP2 gene promoter:
Max1 CUTL1 NF-kappaB POU3F2 HEN1 CREB deltaCREB Pax-4a NF-kappaB1 En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PSTPIP2 promoter sequence

Search SABiosciences Chromatin IP Primers for PSTPIP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSTPIP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12 Ensembl cytogenetic band: 18q21.1 HGNC cytogenetic band: 18q12

PSTPIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSTPIP2 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M043563: view genomic region (about GC identifiers)

Start:	43,563,502 bp from pter	End:	43,652,250 bp from pter
Size:	88,749 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PPIP2_HUMAN, Q9H939 (See protein sequence)

Recommended Name: Proline-serine-threonine phosphatase-interacting protein 2

Size: 334 amino acids; 38858 Da

Subcellular location: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity)

Sequence caution: Sequence=BAB14404.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Alternative splicing: 2 isoforms: Q9H939-1 Q9H939-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PSTPIP2: NX_Q9H939

Explore proteomics data for PSTPIP2 at MOPED

Post-translational modifications:

UniProtKB: Phosphorylated on tyrosine (By similarity)

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9H939

PSTPIP2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_077748.3

ENSEMBL proteins:

ENSP00000468622 ENSP00000387261

Human Recombinant Protein Products for PSTPIP2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for PSTPIP2 OriGene Custom MassSpec OriGene Custom Protein Services for PSTPIP2
	GenScript Custom Purified and Recombinant Proteins Services for PSTPIP2
	Novus Biologicals PSTPIP2 Protein Novus Biologicals PSTPIP2 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for PSTPIP2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	IEA	--
GO:0005856	cytoskeleton	IEA	--
GO:0016020	membrane	IEA	--

PSTPIP2 for ontologies About GeneDecksing

PSTPIP2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for PSTPIP2
	GenScript Custom Superior Antibodies Services for PSTPIP2
	Novus Biologicals PSTPIP2 Antibodies
	Abcam antibodies for PSTPIP2
	Cloud-Clone Corp. Antibodies for PSTPIP2
	ThermoFisher Antibodies for PSTPIP2
	LSBio Antibodies in human, mouse, rat for PSTPIP2

Assay Products for PSTPIP2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for PSTPIP2
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PSTPIP2
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for PSTPIP2 Cloud-Clone Corp. CLIAs for PSTPIP2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR001060 FCH_dom

Graphical View of Domain Structure for InterPro Entry Q9H939

ProtoNet protein and cluster: Q9H939

1 Blocks protein domain: IPB001060 Cdc15/Fes/CIP4

UniProtKB/Swiss-Prot: PPIP2_HUMAN, Q9H939

Similarity: Contains 1 FCH domain

PSTPIP2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PPIP2_HUMAN, Q9H939

Function: Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity)

Phenotypes:
5 GenomeRNAi human phenotypes for PSTPIP2:

Decreased NANOG protein expres	Decreased OCT4 protein express	Decreased POU5F1-GFP protein e	Increased cell death HMECs cel
Increased mitotic index

11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Pstpip2):

behavior/neurological	cellular	craniofacial	hearing/vestibular/ear	hematopoietic system
immune system	integument	limbs/digits/tail	mortality/aging	nervous system
skeleton

PSTPIP2 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for PSTPIP2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PSTPIP2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PSTPIP2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PSTPIP2

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSTPIP2
		8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate PSTPIP2 (see all 41):
		hsa-miR-3607-3p hsa-miR-605 hsa-miR-298 hsa-miR-520g hsa-miR-509-3-5p hsa-miR-3163 hsa-miR-4324 hsa-miR-548am

		SwitchGear 3'UTR luciferase reporter plasmid: PSTPIP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for PSTPIP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSTPIP2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PSTPIP2
			Sirion Biotech Customized adenovirus for overexpression of PSTPIP2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for PSTPIP2 (see all 8) OriGene ORF clones in mouse, rat for PSTPIP2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PSTPIP2 (NM_024430)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSTPIP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSTPIP2
		Sirion Biotech Customized lentivirus for stable overexpression of PSTPIP2 Customized lentivirus expression plasmids for stable overexpression of PSTPIP2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PSTPIP2
		Search LifeMap BioReagents cell lines for PSTPIP2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSTPIP2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PSTPIP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/559 Interacting proteins for PSTPIP2 (Q9H939^{2, 3} ENSP00000387261⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 559)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SHC1	P29353²^,³, ENSP00000401303⁴	MINT-7947479 I2D: score=2 STRING: ENSP00000401303
SHBG	P04278³, ENSP00000369816⁴	I2D: score=2 STRING: ENSP00000369816
GRB2	P62993³, ENSP00000339007⁴	I2D: score=1 STRING: ENSP00000339007
PTPN12	Q05209³, ENSP00000248594⁴	I2D: score=1 STRING: ENSP00000248594
PTPN18	Q99952³, ENSP00000175756⁴	I2D: score=1 STRING: ENSP00000175756

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PSTPIP2 (PPIP2)

Search CenterWatch for drugs/clinical trials and news about PSTPIP2 / PPIP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PSTPIP2 gene:

NM_024430.3

Unigene Cluster for PSTPIP2:

Proline-serine-threonine phosphatase interacting protein 2

Hs.567384 [show with all ESTs]

Unigene Representative Sequence: NM_024430

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000589328 ENST00000409746(uc002lbp.4 uc002lbq.4) ENST00000588801

ENST00000593086 ENST00000591729 ENST00000587042

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSTPIP2
		8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate PSTPIP2 (see all 41):
		hsa-miR-3607-3p hsa-miR-605 hsa-miR-298 hsa-miR-520g hsa-miR-509-3-5p hsa-miR-3163 hsa-miR-4324 hsa-miR-548am

		SwitchGear 3'UTR luciferase reporter plasmid: PSTPIP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for PSTPIP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSTPIP2

Clone Products:		OriGene clones in human, mouse for PSTPIP2 (see all 8) OriGene ORF clones in mouse, rat for PSTPIP2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PSTPIP2 (NM_024430)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSTPIP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSTPIP2
		Sirion Biotech Customized lentivirus for stable overexpression of PSTPIP2 Customized lentivirus expression plasmids for stable overexpression of PSTPIP2

Primer Products:		OriGene qPCR primer pairs and template standards for PSTPIP2 OriGene qSTAR qPCR primer pairs in human, mouse for PSTPIP2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PSTPIP2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSTPIP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSTPIP2

Additional mRNA sequence:

AK023100.1 BC026223.1 BC035395.1

6 DOTS entries:

DT.102827746 DT.95264191 DT.97837155 DT.91758285 DT.95264190 DT.97767136

24/46 AceView cDNA sequences (see all 46):

AI287478 BP337840 NM_024430 BP352927 BC035395 BQ900279 BC026223 BQ072349

AW339515 CN480871 AI383965 AU152596 BX113330 BP357939 W89114 AU130693

BI031151 BU193451 AA577370 BQ943515 AK023100 CD370173 AU151412 AL600767

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PSTPIP2 expression in normal human tissues (normalized intensities) PSTPIP2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ACAGGAAACT

About this image

PSTPIP2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/34 selected tissues (see all 34) fully expand


Epithelium
vagina ; squamous epithelial cells

Uterus
uterus, post-menopause ; glandular cells

Testis (Reproductive System) fully expand to see all 4 entries
Leydig Cells Testis Interstitium
seminal vesicle ; glandular cells

Colon (Gastrointestinal Tract) fully expand to see all 4 entries
colon ; peripheral nerve/ganglion

Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex

See PSTPIP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PSTPIP2

SOURCE GeneReport for Unigene cluster: Hs.567384

SABiosciences Custom PCR Arrays for PSTPIP2

Primer Products:		OriGene qPCR primer pairs and template standards for PSTPIP2 OriGene qSTAR qPCR primer pairs in human, mouse for PSTPIP2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PSTPIP2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSTPIP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSTPIP2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSTPIP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PSTPIP2 gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pstpip2^{1 , 5}	proline-serine-threonine phosphatase-interacting protein more^{1, 5}	85.33(n)¹ 87.43(a)¹		18 (52.38 cM)⁵ 19201¹ NM_013831.4¹ NP_038859.3¹ 77794545⁵
chicken (Gallus gallus)	Aves	PSTPIP2¹	proline-serine-threonine phosphatase interacting protein more	69.27(n) 68.77(a)		770399 XM_001233736.1 XP_001233737.1
lizard (Anolis carolinensis)	Reptilia	PSTPIP2⁶	Uncharacterized protein	72(a)	1 ↔ 1	1(35108646-35164695)
zebrafish (Danio rerio)	Actinopterygii	PSTPIP2 (2 of 2)⁶ CU633857.1⁶	Uncharacterized protein	57(a) 54(a)	1 ↔ many 1 ↔ many	10(7130229-7159155) 10(7160082-7167069)

ENSEMBL Gene Tree for PSTPIP2 (if available)
TreeFam Gene Tree for PSTPIP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PSTPIP2 gene

PSTPIP1²

2 SIMAP similar genes for PSTPIP2 using alignment to 1 protein entry: PPIP2_HUMAN:

PSTPIP1 FCHO2

PSTPIP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs920295^1,2	C,F,A,H	--	43563022(-)	`AACGAG/ATACAT`	1	--	int¹		26		NS EA NA WA	2584
rs182900728^1,2		--	43563106(+)	`ACTAAC/TTCTTT`	1	--	int¹		0	--	--	--	--
rs142509738^1,2	C	--	43563150(+)	`ACAGCA/GGGAAA`	1	--	int¹		0	--	--	--	--
rs187244238^1,2		--	43563216(+)	`GCTTTA/GAACAA`	1	--	int¹		0	--	--	--	--
rs146005313^1,2		--	43563219(+)	`TTGAAC/TAATTA`	1	--	int¹		0	--	--	--	--
rs116940964^1,2	C,F	--	43563236(+)	`AGGGTG/AAATCA`	1	--	int¹		1		NA	120
rs138423315^1,2		--	43563317(+)	`ATGGTA/GTCTCG`	1	--	int¹		0	--	--	--	--
rs147830668^1,2	C	--	43563331(+)	`GGAAG-/TTAACA`	1	--	int¹		0	--	--	--	--
rs191861831^1,2		--	43563335(+)	`AGTAAC/TACTGC`	1	--	int¹		0	--	--	--	--
rs920294^1,2	C,F,A,H	--	43563352(-)	`TCCTTC/TAGAGG`	1	--	int¹		20		NS EA NA WA CSA	1023

HapMap Linkage Disequilibrium report for PSTPIP2 (43563502 - 43652250 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for PSTPIP2: About this table

Variant ID	Type	Subtype	PubMed ID
esv2717027	CNV	Deletion	23290073
esv2717030	CNV	Deletion	23290073
nsv2277	CNV	Loss	18451855

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing PSTPIP2

DNA2.0 Custom Variant and Variant Library Synthesis for PSTPIP2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

8 diseases for PSTPIP2: About MalaCards

sapho syndrome mast-cell leukemia cherubism pyoderma

pyoderma gangrenosum osteomyelitis t-cell leukemia leukemia

3 diseases from the University of Copenhagen DISEASES database for PSTPIP2:

Osteomyelitis SAPHO syndrome mast-cell leukemia

PSTPIP2 for disorders About GeneDecksing

Genetic Association Database (GAD): PSTPIP2
Human Genome Epidemiology (HuGE) Navigator: PSTPIP2 (1 document)

Export disorders for PSTPIP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PSTPIP2 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with PSTPIP2)

Utopia: connect your pdf to the dynamic
world of online information

Genetic susceptibility factors in a cohort of 38 pati ents with SAPHO syndrome: a study of PSTPIP2, NOD2, and LPIN2 genes. (PubMed id 20032092)^{1, 4} Hurtado-Nedelec M....GAcrard B. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase. (PubMed id 9804817)^{1, 3} Wu Y....Lasky L.A. (1998)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PubMed id 21706016)¹ Bisson N....Pawson T. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)¹ Brehme M....Superti-Furga G. (2009)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. (PubMed id 15862967)¹ Pope S.N. and Lee I.R. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9050	HGNC: 9581	AceView: PSTPIP2	Ensembl:ENSG00000152229	euGenes: HUgn9050
ECgene: PSTPIP2	H-InvDB: PSTPIP2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PSTPIP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PSTPIP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PSTPIP2 gene:
Search GeneIP for patents involving PSTPIP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for PSTPIP2
	OriGene qPCR primer pairs and template standards for PSTPIP2		OriGene Protein Over-expression Lysate for PSTPIP2
	OriGene Custom Mass Spec		OriGene clones in human, mouse for PSTPIP2
	OriGene qSTAR qPCR primer pairs in human, mouse for PSTPIP2		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for PSTPIP2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for PSTPIP2		OriGene Custom Protein Services for PSTPIP2

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PSTPIP2
	QIAGEN SeqTarget long-range PCR primers for resequencing PSTPIP2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSTPIP2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSTPIP2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSTPIP2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSTPIP2

	GenScript Custom Purified and Recombinant Proteins Services for PSTPIP2		GenScript cDNA clones with any tag delivered in your preferred vector for PSTPIP2
	GenScript Custom Assay Services for PSTPIP2		GenScript Custom Superior Antibodies Services for PSTPIP2
	GenScript Custom overexpressing Cell Line Services for PSTPIP2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in PSTPIP2 promoter
	Search Chromatin IP Primers for PSTPIP2
	RT² qPCR Primer Assay in human, mouse, rat PSTPIP2
	GNC Network for PSTPIP2
	SABiosciences Custom PCR Arrays for PSTPIP2

Search Tocris compounds for PSTPIP2 (PPIP2)

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	PSTPIP2 antibodies
	PSTPIP2 proteins
	PSTPIP2 lysates

	Antibodies for PSTPIP2
	See all of Abcam's Antibodies, Kits and Proteins for PSTPIP2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for PSTPIP2
	Antibodies for PSTPIP2
	ELISAs for PSTPIP2
	CLIAs for PSTPIP2

Search LifeMap BioReagents cell lines for PSTPIP2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSTPIP2

	SwitchGear 3'UTR luciferase reporter plasmids for PSTPIP2
	SwitchGear Promoter luciferase reporter plasmids for PSTPIP2

ThermoFisher Antibodies for PSTPIP2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSTPIP2

	inGenious Targeting Laboratory - Custom generated mouse model solutions for PSTPIP2
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PSTPIP2

Customized:

	lentivirus for stable overexpression of PSTPIP2
	lentivirus expression plasmids for stable overexpression of PSTPIP2
	adenovirus for overexpression of PSTPIP2

LSBio Antibodies in human, mouse, rat for PSTPIP2

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PSTPIP2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

PSTPIP2 Gene

Proline-Serine-Threonine Phosphatase Interacting Protein...

Aliases
for PSTPIP2 gene

Summaries
for PSTPIP2 gene

Genomic Views
for PSTPIP2 gene

Proteins
for PSTPIP2 gene

Protein Domains /
Families
for PSTPIP2 gene

Function
for PSTPIP2 gene

Pathways & Interactions
for PSTPIP2 gene

Drugs & Compounds
for PSTPIP2 gene

Transcripts
for PSTPIP2 gene

Expression
for PSTPIP2 gene

Orthologs
for PSTPIP2 gene

Paralogs
for PSTPIP2 gene

Genomic Variants
for PSTPIP2 gene

Disorders / Diseases
for PSTPIP2 gene

Publications
for PSTPIP2 gene

External Searches for PSTPIP2 gene

Genome Databases showing PSTPIP2 gene

Other Databases showing PSTPIP2 gene

Specialized Databases showing PSTPIP2 gene

Intellectual Property
for PSTPIP2 gene

Products
for PSTPIP2 gene

View Random Gene

Advanced Search

Export list of displayed genes

PSTPIP2 Gene

Proline-Serine-Threonine Phosphatase Interacting Protein...

Aliasesfor PSTPIP2 gene

Summariesfor PSTPIP2 gene

Genomic Viewsfor PSTPIP2 gene

Proteinsfor PSTPIP2 gene

Protein Domains /Familiesfor PSTPIP2 gene

Functionfor PSTPIP2 gene

Pathways & Interactionsfor PSTPIP2 gene

Drugs & Compoundsfor PSTPIP2 gene

Transcriptsfor PSTPIP2 gene

Expression for PSTPIP2 gene

Orthologsfor PSTPIP2 gene

Paralogsfor PSTPIP2 gene

Genomic Variantsfor PSTPIP2 gene

Disorders / Diseasesfor PSTPIP2 gene

Publicationsfor PSTPIP2 gene

External Searches for PSTPIP2 gene

Genome Databases showing PSTPIP2 gene

Other Databases showing PSTPIP2 gene

Specialized Databases showing PSTPIP2 gene

Intellectual Propertyfor PSTPIP2 gene

Productsfor PSTPIP2 gene

View Random Gene

Aliases
for PSTPIP2 gene

Summaries
for PSTPIP2 gene

Genomic Views
for PSTPIP2 gene

Proteins
for PSTPIP2 gene

Protein Domains /
Families
for PSTPIP2 gene

Function
for PSTPIP2 gene

Pathways & Interactions
for PSTPIP2 gene

Drugs & Compounds
for PSTPIP2 gene

Transcripts
for PSTPIP2 gene

Expression
for PSTPIP2 gene

Orthologs
for PSTPIP2 gene

Paralogs
for PSTPIP2 gene

Genomic Variants
for PSTPIP2 gene

Disorders / Diseases
for PSTPIP2 gene

Publications
for PSTPIP2 gene

Intellectual Property
for PSTPIP2 gene

Products
for PSTPIP2 gene