Aliases for PSTPIP2 Gene
Aliases for PSTPIP2 Gene
External Ids for PSTPIP2 Gene
- HGNC: 9581
- Entrez Gene: 9050
- Ensembl: ENSG00000152229
- OMIM: 616046
- UniProtKB: Q9H939
Previous GeneCards Identifiers for PSTPIP2 Gene
- GC18M043875
- GC18M043350
- GC18M043451
- GC18M041815
- GC18M041817
- GC18M043563
- GC18M040420
Summaries for PSTPIP2 Gene
GeneCards Summary for PSTPIP2 Gene
PSTPIP2 (Proline-Serine-Threonine Phosphatase Interacting Protein 2) is a Protein Coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is PSTPIP1.
UniProtKB/Swiss-Prot for PSTPIP2 Gene
-
Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).
No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSTPIP2 Gene
Genomics for PSTPIP2 Gene
Regulatory Elements for PSTPIP2 Gene
Enhancers for PSTPIP2 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around PSTPIP2 on UCSC Golden Path with GeneCards custom track
Promoters for PSTPIP2 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around PSTPIP2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PSTPIP2 gene promoter:
Regulatory Element Products
Genomic Location for PSTPIP2 Gene
- Chromosome:
- 18
- Start:
- 45,983,536 bp from pter
- End:
- 46,072,297 bp from pter
- Size:
- 88,762 bases
- Orientation:
- Minus strand
Genomic View for PSTPIP2 Gene
Genes around PSTPIP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q21.1 by Ensembl
- 18q12|tdb7990 by Entrez Gene
- 18q12 by HGNC
PSTPIP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSTPIP2 Gene
Proteins for PSTPIP2 Gene
-
Protein details for PSTPIP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H939-PPIP2_HUMAN
- Recommended name:
- Proline-serine-threonine phosphatase-interacting protein 2
- Protein Accession:
- Q9H939
Protein attributes for PSTPIP2 Gene
- Size:
- 334 amino acids
- Molecular mass:
- 38858 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB14404.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for PSTPIP2 Gene
Post-translational modifications for PSTPIP2 Gene
- Phosphorylated on tyrosine.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PSTPIP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for PSTPIP2
- Novus Biologicals Antibodies for PSTPIP2
- Invitrogen Antibodies for PSTPIP2
- antibodies-online Antibodies for PSTPIP2: See all 14
- GeneTex PSTPIP2 antibody for PSTPIP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for PSTPIP2
Protein Products
-
OriGene Purified Proteins for PSTPIP2
- Search Origene for MassSpec and Protein Over-expression Lysates for PSTPIP2
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- antibodies-online Proteins for PSTPIP2: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for PSTPIP2
Assay Products
No data available for DME Specific Peptides for PSTPIP2 Gene
Domains & Families for PSTPIP2 Gene
Protein Domains for PSTPIP2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PSTPIP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H939- Domain:
-
- Contains 1 F-BAR domain.
No data available for Gene Families for PSTPIP2 Gene
Function for PSTPIP2 Gene
Molecular function for PSTPIP2 Gene
- UniProtKB/Swiss-Prot Function:
- Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).
Phenotypes for PSTPIP2 Gene
- MGI mutant phenotypes for PSTPIP2:
-
inferred from 3 alleles
- cellular phenotype
- mortality/aging
- behavior/neurological phenotype
- immune system phenotype
- integument phenotype
- growth/size/body region phenotype
- hematopoietic system phenotype
- nervous system phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- craniofacial phenotype
- hearing/vestibular/ear phenotype
- GenomeRNAi human phenotypes for PSTPIP2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for PSTPIP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PSTPIP2 gene
- Search ViGene Biosciences for PSTPIP2
CRISPR Products
-
OriGene CRISPR knockouts for PSTPIP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSTPIP2
- GenScript: Design CRISPR guide RNA sequences for PSTPIP2
miRNA for PSTPIP2 Gene
- miRTarBase miRNAs that target PSTPIP2
miRNA Products
- Search ViGene Biosciences for PSTPIP2
Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for PSTPIP2
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-
ViGene Biosciences ready-to-package AAV shRNAs for PSTPIP2 gene
Clone Products
- OriGene clones in human for PSTPIP2
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PSTPIP2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PSTPIP2 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSTPIP2 Gene
Localization for PSTPIP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PSTPIP2 Gene
- Cytoplasm. Membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| mitochondrion | 3 |
| nucleus | 3 |
| cytoskeleton | 2 |
| plasma membrane | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | IEA | -- |
Pathways & Interactions for PSTPIP2 Gene
More details on SuperPathways for PSTPIP2
No Data Available
Interacting Proteins for PSTPIP2 Gene
Selected Interacting proteins:
Q9H939-PPIP2_HUMAN
ENSP00000387261
for PSTPIP2 Gene via
MINT
STRING
I2D
No data available for Pathways by source and SIGNOR curated interactions for PSTPIP2 Gene
Transcripts for PSTPIP2 Gene
mRNA/cDNA for PSTPIP2 Gene
- (6) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (46) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PSTPIP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PSTPIP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSTPIP2
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miRNA Products
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Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for PSTPIP2 gene
Clone Products
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Flow Cytometry Products
Expression for PSTPIP2 Gene
mRNA differential expression in normal tissues according to GTEx for PSTPIP2 Gene
This gene is overexpressed in Whole Blood (x16.5) and Spleen (x7.5).
This gene is overexpressed in Peripheral blood mononuclear cells (34.1), Spleen (16.1), and Platelet (9.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSTPIP2 Gene
SOURCE GeneReport for Unigene cluster for PSTPIP2 Gene Hs.567384
Primer Products
-
OriGene qPCR primer pairs for PSTPIP2
-
OriGene qPCR primer pairs and template standards for PSTPIP2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PSTPIP2 Gene
Orthologs for PSTPIP2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | PSTPIP2 35 |
|
||
| PSTPIP2 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | PSTPIP2 35 |
|
||
| PSTPIP2 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Pstpip2 35 |
|
||
| Pstpip2 16 |
|
||||
| Pstpip2 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | PSTPIP2 35 |
|
||
| PSTPIP2 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Pstpip2 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PSTPIP2 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PSTPIP2 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PSTPIP2 35 |
|
||
| PSTPIP2 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | PSTPIP2 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pstpip2 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:ch211-251f6.4 35 |
|
||
| CU633857.1 36 |
|
OneToMany | |||
| PSTPIP2 (1 of 2) 36 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToMany |
- Species with no ortholog for PSTPIP2:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PSTPIP2 Gene
(2) SIMAP similar genes for PSTPIP2 Gene using alignment to 1 proteins:
Variants for PSTPIP2 Gene
| SNP ID | Clin | Chr 18 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs2276199 | - | 45,988,751(-) | ATCCC(A/G)ATTAC | nc-transcript-variant, reference, missense | |
| rs16978507 | - | 45,988,750(+) | AGTAA(C/T)TGGGA | nc-transcript-variant, reference, missense | |
| rs1658900 | -- | 46,049,104(+) | aatcc(A/C)agtga | intron-variant | |
| rs1658901 | -- | 46,049,143(+) | TTTAC(A/C)AGAGT | intron-variant | |
| rs7231846 | -- | 46,037,906(+) | ATCAA(C/T)AATTT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv2277 | CNV | Loss | 18451855 |
| esv2717027 | CNV | Deletion | 23290073 |
| esv2717030 | CNV | Deletion | 23290073 |
Residual Variation Intolerance Score:
38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.56;
82.47% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PSTPIP2 Gene
Disorders for PSTPIP2 Gene
Relevant External Links for PSTPIP2
No disorders were found for PSTPIP2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSTPIP2 Gene
Publications for PSTPIP2 Gene
- Genetic susceptibility factors in a cohort of 38 patients with SAPHO syndrome: a study of PSTPIP2, NOD2, and LPIN2 genes. (PMID: 20032092) Hurtado-Nedelec M. … GAcrard B. (J. Rheumatol. 2010) 3 48 67
- PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase. (PMID: 9804817) Wu Y. … Lasky L.A. (J. Biol. Chem. 1998) 2 3
- Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
- PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN. (PMID: 24407241) Liu L. … Huang Z. (Cell Death Dis 2014) 3
- Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PMID: 21706016) Bisson N. … Pawson T. (Nat. Biotechnol. 2011) 3
Products for PSTPIP2 Gene
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- Custom Antibody ServicesOriGene Antibodies for PSTPIP2
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- OriGene qPCR primer pairs for PSTPIP2
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- Novus Biologicals Antibodies for PSTPIP2
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for PSTPIP2: See all 14
- Search antibodies-online for kits
- antibodies-online Proteins for PSTPIP2: See all 4
- Search antibodies-online for peptides
- GeneTex PSTPIP2 antibody for PSTPIP2
- Search GeneTex for Proteins for PSTPIP2
- ViGene Biosciences adenoviral particle packaged cDNA for PSTPIP2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PSTPIP2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PSTPIP2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PSTPIP2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PSTPIP2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PSTPIP2 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for PSTPIP2
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Sources for PSTPIP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
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- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
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- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
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- (95) miRTarBase
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- (99) Vector BioLabs
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- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
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- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
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