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Aliases for PSTPIP2 Gene

Aliases for PSTPIP2 Gene

  • Proline-Serine-Threonine Phosphatase Interacting Protein 2 2 3 5
  • PEST Phosphatase-Interacting Protein 2 3 4
  • MAYP 3

External Ids for PSTPIP2 Gene

Previous GeneCards Identifiers for PSTPIP2 Gene

  • GC18M043875
  • GC18M043350
  • GC18M043451
  • GC18M041815
  • GC18M041817
  • GC18M043563
  • GC18M040420

Summaries for PSTPIP2 Gene

GeneCards Summary for PSTPIP2 Gene

PSTPIP2 (Proline-Serine-Threonine Phosphatase Interacting Protein 2) is a Protein Coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is PSTPIP1.

UniProtKB/Swiss-Prot for PSTPIP2 Gene

  • Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).

Gene Wiki entry for PSTPIP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSTPIP2 Gene

Genomics for PSTPIP2 Gene

Regulatory Elements for PSTPIP2 Gene

Enhancers for PSTPIP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSTPIP2 on UCSC Golden Path with GeneCards custom track

Promoters for PSTPIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSTPIP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSTPIP2 Gene

45,983,536 bp from pter
46,072,297 bp from pter
88,762 bases
Minus strand

Genomic View for PSTPIP2 Gene

Genes around PSTPIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSTPIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSTPIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSTPIP2 Gene

Proteins for PSTPIP2 Gene

  • Protein details for PSTPIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proline-serine-threonine phosphatase-interacting protein 2
    Protein Accession:

    Protein attributes for PSTPIP2 Gene

    334 amino acids
    Molecular mass:
    38858 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14404.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PSTPIP2 Gene


neXtProt entry for PSTPIP2 Gene

Proteomics data for PSTPIP2 Gene at MOPED

Post-translational modifications for PSTPIP2 Gene

Other Protein References for PSTPIP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PSTPIP2 Gene

Domains & Families for PSTPIP2 Gene

Protein Domains for PSTPIP2 Gene


Suggested Antigen Peptide Sequences for PSTPIP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-BAR domain.
  • Contains 1 F-BAR domain.
genes like me logo Genes that share domains with PSTPIP2: view

No data available for Gene Families for PSTPIP2 Gene

Function for PSTPIP2 Gene

Molecular function for PSTPIP2 Gene

UniProtKB/Swiss-Prot Function:
Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).
genes like me logo Genes that share phenotypes with PSTPIP2: view

Animal Model Products

CRISPR Products

miRNA for PSTPIP2 Gene

miRTarBase miRNAs that target PSTPIP2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSTPIP2 Gene

Localization for PSTPIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSTPIP2 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for PSTPIP2 Gene COMPARTMENTS Subcellular localization image for PSTPIP2 gene
Compartment Confidence
cytosol 4
mitochondrion 3
nucleus 3
cytoskeleton 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PSTPIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with PSTPIP2: view

Pathways & Interactions for PSTPIP2 Gene

SuperPathways for PSTPIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PSTPIP2 Gene


No data available for Pathways by source and SIGNOR curated interactions for PSTPIP2 Gene

Drugs & Compounds for PSTPIP2 Gene

No Compound Related Data Available

Transcripts for PSTPIP2 Gene

Unigene Clusters for PSTPIP2 Gene

Proline-serine-threonine phosphatase interacting protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSTPIP2 Gene

No ASD Table

Relevant External Links for PSTPIP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSTPIP2 Gene

mRNA expression in normal human tissues for PSTPIP2 Gene

mRNA differential expression in normal tissues according to GTEx for PSTPIP2 Gene

This gene is overexpressed in Whole Blood (x16.5) and Spleen (x7.5).

Protein differential expression in normal tissues from HIPED for PSTPIP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (34.1), Spleen (16.1), and Platelet (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSTPIP2 Gene

SOURCE GeneReport for Unigene cluster for PSTPIP2 Gene Hs.567384

genes like me logo Genes that share expression patterns with PSTPIP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PSTPIP2 Gene

Orthologs for PSTPIP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PSTPIP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PSTPIP2 35
  • 90.29 (n)
  • 87.69 (a)
  • 87 (a)
(Canis familiaris)
Mammalia PSTPIP2 35
  • 88.34 (n)
  • 86.69 (a)
  • 87 (a)
(Mus musculus)
Mammalia Pstpip2 35
  • 85.33 (n)
  • 87.43 (a)
Pstpip2 16
Pstpip2 36
  • 87 (a)
(Pan troglodytes)
Mammalia PSTPIP2 35
  • 99.4 (n)
  • 99.1 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Pstpip2 35
  • 85.03 (n)
  • 86.53 (a)
(Monodelphis domestica)
Mammalia PSTPIP2 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia PSTPIP2 36
  • 70 (a)
(Gallus gallus)
Aves PSTPIP2 35
  • 69.26 (n)
  • 68.56 (a)
  • 69 (a)
(Anolis carolinensis)
Reptilia PSTPIP2 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pstpip2 35
  • 65.03 (n)
  • 62.32 (a)
(Danio rerio)
Actinopterygii si:ch211-251f6.4 35
  • 61.87 (n)
  • 60.54 (a)
CU633857.1 36
  • 57 (a)
PSTPIP2 (1 of 2) 36
  • 56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for PSTPIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PSTPIP2 Gene

Gene Tree for PSTPIP2 (if available)
Gene Tree for PSTPIP2 (if available)

Paralogs for PSTPIP2 Gene

Paralogs for PSTPIP2 Gene

(2) SIMAP similar genes for PSTPIP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PSTPIP2: view

Variants for PSTPIP2 Gene

Sequence variations from dbSNP and Humsavar for PSTPIP2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs2276199 - 45,988,751(-) ATCCC(A/G)ATTAC nc-transcript-variant, reference, missense
rs16978507 - 45,988,750(+) AGTAA(C/T)TGGGA nc-transcript-variant, reference, missense
rs1658900 -- 46,049,104(+) aatcc(A/C)agtga intron-variant
rs1658901 -- 46,049,143(+) TTTAC(A/C)AGAGT intron-variant
rs7231846 -- 46,037,906(+) ATCAA(C/T)AATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSTPIP2 Gene

Variant ID Type Subtype PubMed ID
nsv2277 CNV Loss 18451855
esv2717027 CNV Deletion 23290073
esv2717030 CNV Deletion 23290073

Variation tolerance for PSTPIP2 Gene

Residual Variation Intolerance Score: 38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.56; 82.47% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PSTPIP2 Gene

Disorders for PSTPIP2 Gene

Relevant External Links for PSTPIP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PSTPIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSTPIP2 Gene

Publications for PSTPIP2 Gene

  1. Genetic susceptibility factors in a cohort of 38 patients with SAPHO syndrome: a study of PSTPIP2, NOD2, and LPIN2 genes. (PMID: 20032092) Hurtado-Nedelec M. … GAcrard B. (J. Rheumatol. 2010) 3 48 67
  2. PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase. (PMID: 9804817) Wu Y. … Lasky L.A. (J. Biol. Chem. 1998) 2 3
  3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  4. PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN. (PMID: 24407241) Liu L. … Huang Z. (Cell Death Dis 2014) 3
  5. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PMID: 21706016) Bisson N. … Pawson T. (Nat. Biotechnol. 2011) 3

Products for PSTPIP2 Gene

Sources for PSTPIP2 Gene