Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PSTPIP2 Gene

protein-coding   GIFtS: 53
GCID: GC18M043563

Proline-Serine-Threonine Phosphatase Interacting Protein...
  8 related diseases
at
MalaCards
 

Aliases
for PSTPIP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Proline-Serine-Threonine Phosphatase Interacting Protein 21 2
PEST Phosphatase-Interacting Protein 22 3
MAYP2
Proline-Serine-Threonine Phosphatase-Interacting Protein 22

External Ids:    HGNC: 95811   Entrez Gene: 90502   Ensembl: ENSG000001522297   UniProtKB: Q9H9393   

Export aliases for PSTPIP2 gene to outside databases

Previous GC identifers: GC18M043875 GC18M043350 GC18M043451 GC18M041815 GC18M041817 GC18M040420


Summaries
for PSTPIP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for PSTPIP2 Gene: 
PSTPIP2 (proline-serine-threonine phosphatase interacting protein 2) is a protein-coding gene. Diseases associated with PSTPIP2 include sapho syndrome, and mast-cell leukemia. An important paralog of this gene is PSTPIP1.

UniProtKB/Swiss-Prot: PPIP2_HUMAN, Q9H939
Function: Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity)

Gene Wiki entry for PSTPIP2 Gene


Genomic Views
for PSTPIP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_010966.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PSTPIP2 gene promoter:
         Max1   CUTL1   NF-kappaB   POU3F2   HEN1   CREB   deltaCREB   Pax-4a   NF-kappaB1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PSTPIP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PSTPIP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSTPIP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12   Ensembl cytogenetic band:  18q21.1   HGNC cytogenetic band: 18q12

PSTPIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSTPIP2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M043563:  view genomic region     (about GC identifiers)

Start:
 43,563,502 bp from pter      End:
 43,652,250 bp from pter
Size:
 88,749 bases      Orientation:
 minus strand

Proteins
for PSTPIP2 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: PPIP2_HUMAN, Q9H939 (See protein sequence)
Recommended Name: Proline-serine-threonine phosphatase-interacting protein 2  
Size: 334 amino acids; 38858 Da
Subcellular location: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity)
Sequence caution: Sequence=BAB14404.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Alternative splicing: 2 isoforms:  Q9H939-1   Q9H939-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PSTPIP2: NX_Q9H939

Explore proteomics data for PSTPIP2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H939

    • PSTPIP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PSTPIP2 Protein Expression
    REFSEQ proteins: NP_077748.3  
    ENSEMBL proteins: 
     ENSP00000468622   ENSP00000387261  

    Human Recombinant Protein Products for PSTPIP2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PSTPIP2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PSTPIP2
    GenScript Custom Purified and Recombinant Proteins Services for PSTPIP2
    Novus Biologicals PSTPIP2 Protein
    Novus Biologicals PSTPIP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PSTPIP2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--
    GO:0005856cytoskeleton IEA--
    GO:0016020membrane IEA--

    PSTPIP2 for ontologies           About GeneDecksing



    PSTPIP2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PSTPIP2
    GenScript Custom Superior Antibodies Services for PSTPIP2
    Novus Biologicals PSTPIP2 Antibodies
    Abcam antibodies for PSTPIP2
    Cloud-Clone Corp. Antibodies for PSTPIP2 
    ThermoFisher Antibodies for PSTPIP2
    LSBio Antibodies in human, mouse, rat for PSTPIP2 

    Assay Products for PSTPIP2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PSTPIP2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PSTPIP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PSTPIP2 
    Cloud-Clone Corp. CLIAs for PSTPIP2

    Protein Domains /
    Families
    for PSTPIP2 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 1 InterPro protein domain:
     IPR001060 FCH_dom

    Graphical View of Domain Structure for InterPro Entry Q9H939

    ProtoNet protein and cluster: Q9H939

    1 Blocks protein domain: IPB001060 Cdc15/Fes/CIP4

    UniProtKB/Swiss-Prot: PPIP2_HUMAN, Q9H939
    Similarity: Contains 1 FCH domain


    PSTPIP2 for domains           About GeneDecksing


    Function
    for PSTPIP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPIP2_HUMAN, Q9H939
    Function: Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity)

    Phenotypes:
         5 GenomeRNAi human phenotypes for PSTPIP2:

     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Increased cell death HMECs cel 
     Increased mitotic index 

         11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Pstpip2):
     behavior/neurological  cellular  craniofacial  hearing/vestibular/ear  hematopoietic system 
     immune system  integument  limbs/digits/tail  mortality/aging  nervous system 
     skeleton 

    PSTPIP2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PSTPIP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PSTPIP2

    miRNA
    Products:        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSTPIP2
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate PSTPIP2 (see all 41):
    hsa-miR-3607-3p hsa-miR-605 hsa-miR-298 hsa-miR-520g hsa-miR-509-3-5p hsa-miR-3163 hsa-miR-4324 hsa-miR-548am
    SwitchGear 3'UTR luciferase reporter plasmid: PSTPIP2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PSTPIP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSTPIP2
    Sirion Biotech Custom design and validation of potent shRNA sequences against PSTPIP2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PSTPIP2
    Sirion Biotech Customized adenovirus for overexpression of PSTPIP2
                         Customized adenovirus for potent knockdown of PSTPIP2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PSTPIP2 (see all 8)
    OriGene ORF clones in mouse, rat for PSTPIP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PSTPIP2 (NM_024430)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSTPIP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSTPIP2

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PSTPIP2
    Search LifeMap BioReagents cell lines for PSTPIP2
    Sirion Biotech Customized stable knockdown cell line services for PSTPIP2
                         Customized inducible knockdown cell line services for PSTPIP2
                         Customized stable overexpressing cell line services for PSTPIP2
                         Customized inducible overexpressing cell line services for PSTPIP2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSTPIP2


    Pathways & Interactions
    for PSTPIP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PSTPIP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/559 Interacting proteins for PSTPIP2 (Q9H9392, 3 ENSP000003872614) via UniProtKB, MINT, STRING, and/or I2D (see all 559)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SHC1P293532, 3, ENSP000004013034MINT-7947479 I2D: score=2 STRING: ENSP00000401303
    SHBGP042783, ENSP000003698164I2D: score=2 STRING: ENSP00000369816
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    PTPN12Q052093, ENSP000002485944I2D: score=1 STRING: ENSP00000248594
    PTPN18Q999523, ENSP000001757564I2D: score=1 STRING: ENSP00000175756
    About this table

    Drugs & Compounds
    for PSTPIP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PSTPIP2 (PPIP2)

    Search CenterWatch for drugs/clinical trials and news about PSTPIP2 / PPIP2

    Transcripts
    for PSTPIP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PSTPIP2 gene: 
    NM_024430.3  

    Unigene Cluster for PSTPIP2:

    Proline-serine-threonine phosphatase interacting protein 2
    Hs.567384  [show with all ESTs]
    Unigene Representative Sequence: NM_024430
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589328 ENST00000409746(uc002lbp.4 uc002lbq.4) ENST00000588801
    ENST00000593086 ENST00000591729 ENST00000587042
    miRNA
    Products:         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSTPIP2
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate PSTPIP2 (see all 41):
    hsa-miR-3607-3p hsa-miR-605 hsa-miR-298 hsa-miR-520g hsa-miR-509-3-5p hsa-miR-3163 hsa-miR-4324 hsa-miR-548am
    SwitchGear 3'UTR luciferase reporter plasmid: PSTPIP2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PSTPIP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSTPIP2
    Sirion Biotech Custom design and validation of potent shRNA sequences against PSTPIP2
    Clone
    Products:             		 OriGene clones in human, mouse for PSTPIP2 (see all 8)
    OriGene ORF clones in mouse, rat for PSTPIP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PSTPIP2 (NM_024430)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSTPIP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSTPIP2
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for PSTPIP2
    OriGene qSTAR qPCR primer pairs in human, mouse for PSTPIP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PSTPIP2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSTPIP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSTPIP2

    Additional mRNA sequence: 

    AK023100.1 BC026223.1 BC035395.1 

    6 DOTS entries:

    DT.102827746  DT.95264191  DT.97837155  DT.91758285  DT.95264190  DT.97767136 

    24/46 AceView cDNA sequences (see all 46):

    AI287478 BP337840 NM_024430 BP352927 BC035395 BQ900279 BC026223 BQ072349 
    AW339515 CN480871 AI383965 AU152596 BX113330 BP357939 W89114 AU130693 
    BI031151 BU193451 AA577370 BQ943515 AK023100 CD370173 AU151412 AL600767 

    GeneLoc Exon Structure


    Expression
    for PSTPIP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PSTPIP2 expression in normal human tissues (normalized intensities)      PSTPIP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGGAAACT
    PSTPIP2 Expression
    About this image


    PSTPIP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Reproductive System (Reproductive System)    fully expand to see all 7 entries
             vagina ; squamous epithelial cells
     
     Skin (Integumentary System)    fully expand to see all 5 entries
             skin ; keratinocytes
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Tonsil
             tonsil ; squamous epithelial cells

    See PSTPIP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PSTPIP2

    SOURCE GeneReport for Unigene cluster: Hs.567384
        SABiosciences Custom PCR Arrays for PSTPIP2
    Primer
    Products:    		OriGene qPCR primer pairs and template standards for PSTPIP2
    OriGene qSTAR qPCR primer pairs in human, mouse for PSTPIP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PSTPIP2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSTPIP2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSTPIP2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSTPIP2

    Orthologs
    for PSTPIP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for PSTPIP2 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Pstpip21 , 5 proline-serine-threonine phosphatase-interacting protein more1, 5 85.33(n)1
    87.43(a)1    		   18 (52.38 cM)5
    192011  NM_013831.41  NP_038859.31 
     777945455 
    chicken
    (Gallus gallus)    		 Aves PSTPIP21 proline-serine-threonine phosphatase interacting protein more 69.27(n)
    68.77(a)    		   770399  XM_001233736.1  XP_001233737.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PSTPIP26
    		 Uncharacterized protein
    		 72(a)
    		 1 ↔ 1
    		 1(35108646-35164695)
    zebrafish
    (Danio rerio)    		 Actinopterygii PSTPIP2 (2 of 2)6
    CU633857.16
    		 Uncharacterized protein
    		 57(a)
    54(a)
    		 1 ↔ many
    1 ↔ many
    		 10(7130229-7159155)
    10(7160082-7167069)


    ENSEMBL Gene Tree for PSTPIP2 (if available)
    TreeFam Gene Tree for PSTPIP2 (if available)

    Paralogs
    for PSTPIP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PSTPIP2 gene
    PSTPIP12  
    2 SIMAP similar genes for PSTPIP2 using alignment to 1 protein entry:     PPIP2_HUMAN:
    PSTPIP1    FCHO2

    PSTPIP2 for paralogs           About GeneDecksing



    Genomic Variants
    for PSTPIP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1908 SNPs in PSTPIP2 are shown (see all 1908)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs9202951,2
    		C,F,A,H--43563022(-) AACGAG/ATACAT 1 -- int126Minor allele frequency- A:0.23NS EA NA WA 2584
    rs1829007281,2
    		--43563106(+) ACTAAC/TTCTTT 1 -- int10--------
    rs1425097381,2
    		C--43563150(+) ACAGCA/GGGAAA 1 -- int10--------
    rs1872442381,2
    		--43563216(+) GCTTTA/GAACAA 1 -- int10--------
    rs1460053131,2
    		--43563219(+) TTGAAC/TAATTA 1 -- int10--------
    rs1169409641,2
    		C,F--43563236(+) AGGGTG/AAATCA 1 -- int11Minor allele frequency- A:0.02NA 120
    rs1384233151,2
    		--43563317(+) ATGGTA/GTCTCG 1 -- int10--------
    rs1478306681,2
    		C--43563331(+) GGAAG-/TTAACA 1 -- int10--------
    rs1918618311,2
    		--43563335(+) AGTAAC/TACTGC 1 -- int10--------
    rs9202941,2
    		C,F,A,H--43563352(-) TCCTTC/TAGAGG 1 -- int120Minor allele frequency- T:0.35NS EA NA WA CSA 1023

    HapMap Linkage Disequilibrium report for PSTPIP2 (43563502 - 43652250 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PSTPIP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2717027CNV Deletion23290073
    esv2717030CNV Deletion23290073
    nsv2277CNV Loss18451855

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PSTPIP2
    DNA2.0 Custom Variant and Variant Library Synthesis for PSTPIP2

    Disorders / Diseases
    for PSTPIP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PSTPIP2 for disorders           About GeneDecksing

    8 diseases for PSTPIP2:    About MalaCards
    sapho syndrome    mast-cell leukemia    cherubism    pyoderma
    pyoderma gangrenosum    osteomyelitis    t-cell leukemia    leukemia

    3 diseases from the University of Copenhagen DISEASES database for PSTPIP2:
    Osteomyelitis     SAPHO syndrome     mast-cell leukemia
    Genetic Association Database (GAD): PSTPIP2
    Human Genome Epidemiology (HuGE) Navigator: PSTPIP2 (1 document)

    Export disorders for PSTPIP2 gene to outside databases

    Publications
    for PSTPIP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PSTPIP2 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with PSTPIP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic susceptibility factors in a cohort of 38 pati ents with SAPHO syndrome: a study of PSTPIP2, NOD2, and LPIN2 genes. (PubMed id 20032092)1, 4 Hurtado-Nedelec M....GAcrard B. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase. (PubMed id 9804817)1, 3 Wu Y....Lasky L.A. (1998)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PubMed id 21706016)1 Bisson N....Pawson T. (2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. (PubMed id 15862967)1 Pope S.N. and Lee I.R. (2005)

    External Searches for PSTPIP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PSTPIP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9050 HGNC: 9581 AceView: PSTPIP2 Ensembl:ENSG00000152229 euGenes: HUgn9050
    ECgene: PSTPIP2 H-InvDB: PSTPIP2

    Other Databases showing PSTPIP2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PSTPIP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PSTPIP2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PSTPIP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PSTPIP2 gene:
    Search GeneIP for patents involving PSTPIP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for PSTPIP2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PSTPIP2  
     OriGene qPCR primer pairs and template standards for PSTPIP2   OriGene Protein Over-expression Lysate for PSTPIP2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PSTPIP2  
     OriGene qSTAR qPCR primer pairs in human, mouse for PSTPIP2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PSTPIP2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PSTPIP2   OriGene Custom Protein Services for PSTPIP2  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PSTPIP2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PSTPIP2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSTPIP2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSTPIP2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSTPIP2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSTPIP2
     GenScript Custom Purified and Recombinant Proteins Services for PSTPIP2 GenScript cDNA clones with any tag delivered in your preferred vector for PSTPIP2
     GenScript Custom Assay Services for PSTPIP2 GenScript Custom Superior Antibodies Services for PSTPIP2
     GenScript Custom overexpressing Cell Line Services for PSTPIP2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PSTPIP2 promoter
     Search Chromatin IP Primers for PSTPIP2
     RT2 qPCR Primer Assay in human, mouse, rat PSTPIP2
     GNC Network for PSTPIP2
     SABiosciences Custom PCR Arrays for PSTPIP2
     Search Tocris compounds for PSTPIP2 (PPIP2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PSTPIP2 antibodies
     PSTPIP2 proteins
     PSTPIP2 lysates
     Antibodies for PSTPIP2
     See all of Abcam's Antibodies, Kits and Proteins for PSTPIP2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for PSTPIP2
     Antibodies for PSTPIP2
     ELISAs for PSTPIP2
     CLIAs for PSTPIP2
     Search LifeMap BioReagents cell lines for PSTPIP2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSTPIP2
     SwitchGear 3'UTR luciferase reporter plasmids for PSTPIP2
     SwitchGear Promoter luciferase reporter plasmids for PSTPIP2
     ThermoFisher Antibodies for PSTPIP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSTPIP2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PSTPIP2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PSTPIP2
    Customized:
     stable knockdown cell line services for PSTPIP2
     inducible knockdown cell line services for PSTPIP2
     design and validation of potent shRNA sequences against PSTPIP2
     adenovirus for potent knockdown of PSTPIP2
     stable overexpressing cell line services for PSTPIP2
     inducible overexpressing cell line services for PSTPIP2
     adenovirus for overexpression of PSTPIP2
     LSBio Antibodies in human, mouse, rat for PSTPIP2
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      PSTPIP2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4