Aliases for PSTPIP2 Gene
Aliases for PSTPIP2 Gene
External Ids for PSTPIP2 Gene
- HGNC: 9581
- Entrez Gene: 9050
- Ensembl: ENSG00000152229
- OMIM: 616046
- UniProtKB: Q9H939
Previous GeneCards Identifiers for PSTPIP2 Gene
- GC18M043875
- GC18M043350
- GC18M043451
- GC18M041815
- GC18M041817
- GC18M043563
- GC18M040420
Summaries for PSTPIP2 Gene
GeneCards Summary for PSTPIP2 Gene
PSTPIP2 (Proline-Serine-Threonine Phosphatase Interacting Protein 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is PSTPIP1.
UniProtKB/Swiss-Prot for PSTPIP2 Gene
-
Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).
Additional gene information for PSTPIP2 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSTPIP2 Gene
Genomics for PSTPIP2 Gene
GeneHancer (GH) Regulatory Elements for PSTPIP2 Gene
Regulatory Element Products
Genomic Locations for PSTPIP2 Gene
- chr18:45,983,536-46,072,297
- (GRCh38/hg38)
- Size:
- 88,762 bases
- Orientation:
- Minus strand
- chr18:43,563,502-43,652,250
- (GRCh37/hg19)
Genomic View for PSTPIP2 Gene
- Cytogenetic band:
-
- 18q21.1 by Ensembl
- 18q21.1|tdb7990 by Entrez Gene
- 18q21.1 by HGNC


RefSeq DNA sequence for PSTPIP2 Gene
Proteins for PSTPIP2 Gene
-
Protein details for PSTPIP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H939-PPIP2_HUMAN
- Recommended name:
- Proline-serine-threonine phosphatase-interacting protein 2
- Protein Accession:
- Q9H939
Protein attributes for PSTPIP2 Gene
- Size:
- 334 amino acids
- Molecular mass:
- 38858 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB14404.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for PSTPIP2 Gene
Post-translational modifications for PSTPIP2 Gene
- Phosphorylated on tyrosine.
Other Protein References for PSTPIP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
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Protein Products
-
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Quality Products:
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Abcam proteins for PSTPIP2
Assay Products
No data available for DME Specific Peptides for PSTPIP2 Gene
Domains & Families for PSTPIP2 Gene
Gene Families for PSTPIP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PSTPIP2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PSTPIP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for PSTPIP2 Gene
Function for PSTPIP2 Gene
Molecular function for PSTPIP2 Gene
- UniProtKB/Swiss-Prot Function:
- Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).
Phenotypes From GWAS Catalog for PSTPIP2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003779 | actin binding | IEA | -- |
Phenotypes for PSTPIP2 Gene
- MGI mutant phenotypes for PSTPIP2:
-
inferred from 3 alleles
- nervous system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- hearing/vestibular/ear phenotype
- integument phenotype
- hematopoietic system phenotype
- skeleton phenotype
- craniofacial phenotype
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for PSTPIP2:
Animal Model Products
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-
-
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-
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CRISPR Products
-
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Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for PSTPIP2 Gene
- miRTarBase miRNAs that target PSTPIP2
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Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PSTPIP2
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Clone Products
- Sino Biological Human cDNA Clone for PSTPIP2
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PSTPIP2 gene related products
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSTPIP2 Gene
Localization for PSTPIP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PSTPIP2 Gene
- Cytoplasm. Membrane; Peripheral membrane protein.
- Mitochondria (2)
- Nucleus (2)
- Plasma membrane (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IEA | -- |
GO:0005856 | cytoskeleton | IEA | -- |
GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for PSTPIP2 Gene
Interacting Proteins for PSTPIP2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007010 | cytoskeleton organization | IEA | -- |
GO:0016477 | cell migration | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for PSTPIP2 Gene
Transcripts for PSTPIP2 Gene
mRNA/cDNA for PSTPIP2 Gene
- (4) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (46) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PSTPIP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PSTPIP2
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSTPIP2
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miRNA Products
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Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PSTPIP2 gene related products
- orf clones - Search results for available PSTPIP2 gene related products
- Applied Biological Materials Clones for PSTPIP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PSTPIP2 Gene
mRNA differential expression in normal tissues according to GTEx for PSTPIP2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSTPIP2 Gene
NURSA nuclear receptor signaling pathways regulating expression of PSTPIP2 Gene:
PSTPIP2SOURCE GeneReport for Unigene cluster for PSTPIP2 Gene:
Hs.567384Evidence on tissue expression from TISSUES for PSTPIP2 Gene
- Blood(2.2)
Primer Products
-
OriGene qPCR primer pairs for PSTPIP2
-
OriGene qPCR primer pairs and template standards for PSTPIP2
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSTPIP2 Gene
Orthologs for PSTPIP2 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PSTPIP2 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | PSTPIP2 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | PSTPIP2 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Pstpip2 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Pstpip2 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | PSTPIP2 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | PSTPIP2 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | PSTPIP2 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | PSTPIP2 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | pstpip2 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | si:ch211-251f6.4 33 |
|
||
CU633857.1 34 |
|
OneToMany | |||
PSTPIP2 (1 of 2) 34 |
|
OneToMany | |||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for PSTPIP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PSTPIP2 Gene
Variants for PSTPIP2 Gene
SNP ID | Clin | Chr 18 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000103549 | -- | 46,044,891(-) | AAAAAA/AAAAAAA | genic_upstream_transcript_variant, intron_variant | |
rs1000136214 | -- | 46,045,142(-) | A/T | genic_upstream_transcript_variant, intron_variant | |
rs1000158153 | -- | 45,995,235(-) | T/C | intron_variant | |
rs1000196703 | -- | 45,989,485(-) | G/A | intron_variant | |
rs1000204799 | -- | 46,018,546(-) | T/C | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2717027 | CNV | deletion | 23290073 |
esv2717030 | CNV | deletion | 23290073 |
esv3642418 | CNV | gain | 21293372 |
esv3642419 | CNV | loss | 21293372 |
esv3642420 | CNV | gain | 21293372 |
esv3642421 | CNV | loss | 21293372 |
esv3642422 | CNV | gain | 21293372 |
nsv2277 | CNV | deletion | 18451855 |
nsv477286 | CNV | novel sequence insertion | 20440878 |
Additional Variant Information for PSTPIP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PSTPIP2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSTPIP2 Gene
Disorders for PSTPIP2 Gene
Additional Disease Information for PSTPIP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PSTPIP2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSTPIP2 Gene
Publications for PSTPIP2 Gene
- Genetic susceptibility factors in a cohort of 38 patients with SAPHO syndrome: a study of PSTPIP2, NOD2, and LPIN2 genes. (PMID: 20032092) Hurtado-Nedelec M … Gérard B (The Journal of rheumatology 2010) 3 44 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase. (PMID: 9804817) Wu Y … Lasky LA (The Journal of biological chemistry 1998) 2 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for PSTPIP2 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 16 available PSTPIP2 Antibodies ranked by validation data
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Sources for PSTPIP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew