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Aliases for PSTPIP2 Gene

Aliases for PSTPIP2 Gene

  • Proline-Serine-Threonine Phosphatase Interacting Protein 2 2 3 5
  • PEST Phosphatase-Interacting Protein 2 3 4
  • Proline-Serine-Threonine Phosphatase-Interacting Protein 2 3
  • MAYP 3

External Ids for PSTPIP2 Gene

Previous GeneCards Identifiers for PSTPIP2 Gene

  • GC18M043875
  • GC18M043350
  • GC18M043451
  • GC18M041815
  • GC18M041817
  • GC18M043563
  • GC18M040420

Summaries for PSTPIP2 Gene

GeneCards Summary for PSTPIP2 Gene

PSTPIP2 (Proline-Serine-Threonine Phosphatase Interacting Protein 2) is a Protein Coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is PSTPIP1.

UniProtKB/Swiss-Prot for PSTPIP2 Gene

  • Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).

Gene Wiki entry for PSTPIP2 Gene

Additional gene information for PSTPIP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSTPIP2 Gene

Genomics for PSTPIP2 Gene

Regulatory Elements for PSTPIP2 Gene

Enhancers for PSTPIP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H046013 1.3 FANTOM5 ENCODE dbSUPER 22.2 +58.7 58674 0 CBFB ZBED1 JUNB BMI1 BATF BCL11A IKZF1 EED ETV6 RUNX3 PSTPIP2 EPG5 RNY4P37 LOC100422497 RN7SKP26
GH18H046008 1.3 FANTOM5 Ensembl ENCODE dbSUPER 20.7 +62.8 62809 1 TCF12 NCOR1 TAL1 HNF4A RAD21 PSTPIP2 EPG5 RNY4P37 SLC14A2 LOC100422497 RN7SKP26
GH18H045960 1.5 FANTOM5 Ensembl ENCODE dbSUPER 16.1 +109.6 109587 3 PKNOX1 SAP130 NR2F1 ELF1 MITF JUND IKZF1 HMBOX1 RUNX3 IKZF2 EPG5 PSTPIP2 RNY4P37 C18orf25 GC18M045898
GH18H045973 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.8 +98.0 97983 1 ELF3 CTCF ARNT ZNF384 CEBPG RAD21 RFX5 TEAD3 IRF9 SLC30A9 EPG5 PSTPIP2 RN7SKP26
GH18H046039 1.3 Ensembl ENCODE dbSUPER 13.7 +32.0 31973 1 LEF1 TAL1 TCF12 ZNF316 CTBP1 GATA2 NCOR1 POLR2A EGR1 ZNF584 HAUS1 PSTPIP2 RNY4P37 LOC100422497
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSTPIP2 on UCSC Golden Path with GeneCards custom track

Promoters for PSTPIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000102860 197 1001 ATF1 ZNF2 RAD21 GLIS2 ZNF143 ZNF391 CREM SMAD5 REST ZFP69B

Genomic Location for PSTPIP2 Gene

Chromosome:
18
Start:
45,983,536 bp from pter
End:
46,072,297 bp from pter
Size:
88,762 bases
Orientation:
Minus strand

Genomic View for PSTPIP2 Gene

Genes around PSTPIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSTPIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSTPIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSTPIP2 Gene

Proteins for PSTPIP2 Gene

  • Protein details for PSTPIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H939-PPIP2_HUMAN
    Recommended name:
    Proline-serine-threonine phosphatase-interacting protein 2
    Protein Accession:
    Q9H939

    Protein attributes for PSTPIP2 Gene

    Size:
    334 amino acids
    Molecular mass:
    38858 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14404.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PSTPIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSTPIP2 Gene

Post-translational modifications for PSTPIP2 Gene

Other Protein References for PSTPIP2 Gene

No data available for DME Specific Peptides for PSTPIP2 Gene

Domains & Families for PSTPIP2 Gene

Gene Families for PSTPIP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PSTPIP2 Gene

Suggested Antigen Peptide Sequences for PSTPIP2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PSTPIP2: view

No data available for UniProtKB/Swiss-Prot for PSTPIP2 Gene

Function for PSTPIP2 Gene

Molecular function for PSTPIP2 Gene

UniProtKB/Swiss-Prot Function:
Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).

Phenotypes From GWAS Catalog for PSTPIP2 Gene

Gene Ontology (GO) - Molecular Function for PSTPIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with PSTPIP2: view
genes like me logo Genes that share phenotypes with PSTPIP2: view

Animal Model Products

CRISPR Products

miRNA for PSTPIP2 Gene

miRTarBase miRNAs that target PSTPIP2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PSTPIP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSTPIP2 Gene

Localization for PSTPIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSTPIP2 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSTPIP2 gene
Compartment Confidence
cytosol 4
mitochondrion 3
nucleus 3
plasma membrane 2
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSTPIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PSTPIP2: view

Pathways & Interactions for PSTPIP2 Gene

SuperPathways for PSTPIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PSTPIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0016477 cell migration IEA --
genes like me logo Genes that share ontologies with PSTPIP2: view

No data available for Pathways by source and SIGNOR curated interactions for PSTPIP2 Gene

Drugs & Compounds for PSTPIP2 Gene

No Compound Related Data Available

Transcripts for PSTPIP2 Gene

Unigene Clusters for PSTPIP2 Gene

Proline-serine-threonine phosphatase interacting protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PSTPIP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PSTPIP2 Gene

No ASD Table

Relevant External Links for PSTPIP2 Gene

GeneLoc Exon Structure for
PSTPIP2
ECgene alternative splicing isoforms for
PSTPIP2

Expression for PSTPIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSTPIP2 Gene

mRNA differential expression in normal tissues according to GTEx for PSTPIP2 Gene

This gene is overexpressed in Whole Blood (x16.5) and Spleen (x7.5).

Protein differential expression in normal tissues from HIPED for PSTPIP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (34.1), Spleen (16.1), and Platelet (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSTPIP2 Gene



NURSA nuclear receptor signaling pathways regulating expression of PSTPIP2 Gene:

PSTPIP2

SOURCE GeneReport for Unigene cluster for PSTPIP2 Gene:

Hs.567384

Evidence on tissue expression from TISSUES for PSTPIP2 Gene

  • Blood(2.2)
genes like me logo Genes that share expression patterns with PSTPIP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSTPIP2 Gene

Orthologs for PSTPIP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PSTPIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSTPIP2 33 34
  • 99.4 (n)
cow
(Bos Taurus)
Mammalia PSTPIP2 33 34
  • 90.29 (n)
dog
(Canis familiaris)
Mammalia PSTPIP2 33 34
  • 88.34 (n)
mouse
(Mus musculus)
Mammalia Pstpip2 33 16 34
  • 85.33 (n)
rat
(Rattus norvegicus)
Mammalia Pstpip2 33
  • 85.03 (n)
oppossum
(Monodelphis domestica)
Mammalia PSTPIP2 34
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSTPIP2 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSTPIP2 33 34
  • 69.26 (n)
lizard
(Anolis carolinensis)
Reptilia PSTPIP2 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pstpip2 33
  • 65.03 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-251f6.4 33
  • 61.87 (n)
CU633857.1 34
  • 57 (a)
OneToMany
PSTPIP2 (1 of 2) 34
  • 56 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
OneToMany
Species where no ortholog for PSTPIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PSTPIP2 Gene

ENSEMBL:
Gene Tree for PSTPIP2 (if available)
TreeFam:
Gene Tree for PSTPIP2 (if available)

Paralogs for PSTPIP2 Gene

Paralogs for PSTPIP2 Gene

(2) SIMAP similar genes for PSTPIP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PSTPIP2: view

Variants for PSTPIP2 Gene

Sequence variations from dbSNP and Humsavar for PSTPIP2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000103549 -- 46,044,890(+) CAGCC(-/A)AAAAA intron-variant
rs1000136214 -- 46,045,142(+) GACCC(A/T)GCCAT intron-variant
rs1000158153 -- 45,995,235(+) TCAGG(C/T)TCCCA intron-variant
rs1000196703 -- 45,989,485(+) ATTAA(A/G)CCTCT intron-variant
rs1000204799 -- 46,018,546(+) GTATT(C/T)TTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSTPIP2 Gene

Variant ID Type Subtype PubMed ID
esv2717027 CNV deletion 23290073
esv2717030 CNV deletion 23290073
esv3642418 CNV gain 21293372
esv3642419 CNV loss 21293372
esv3642420 CNV gain 21293372
esv3642421 CNV loss 21293372
esv3642422 CNV gain 21293372
nsv2277 CNV deletion 18451855
nsv477286 CNV novel sequence insertion 20440878

Variation tolerance for PSTPIP2 Gene

Residual Variation Intolerance Score: 38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.56; 82.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSTPIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSTPIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSTPIP2 Gene

Disorders for PSTPIP2 Gene

Relevant External Links for PSTPIP2

Genetic Association Database (GAD)
PSTPIP2
Human Genome Epidemiology (HuGE) Navigator
PSTPIP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSTPIP2

No disorders were found for PSTPIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSTPIP2 Gene

Publications for PSTPIP2 Gene

  1. Genetic susceptibility factors in a cohort of 38 patients with SAPHO syndrome: a study of PSTPIP2, NOD2, and LPIN2 genes. (PMID: 20032092) Hurtado-Nedelec M … Gérard B (The Journal of rheumatology 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase. (PMID: 9804817) Wu Y … Lasky LA (The Journal of biological chemistry 1998) 2 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for PSTPIP2 Gene

Sources for PSTPIP2 Gene

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