Aliases for PSTPIP2 Gene
Aliases for PSTPIP2 Gene
External Ids for PSTPIP2 Gene
- HGNC: 9581
- Entrez Gene: 9050
- Ensembl: ENSG00000152229
- OMIM: 616046
- UniProtKB: Q9H939
Previous GeneCards Identifiers for PSTPIP2 Gene
- GC18M043875
- GC18M043350
- GC18M043451
- GC18M041815
- GC18M041817
- GC18M043563
- GC18M040420
Summaries for PSTPIP2 Gene
GeneCards Summary for PSTPIP2 Gene
PSTPIP2 (Proline-Serine-Threonine Phosphatase Interacting Protein 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is PSTPIP1.
UniProtKB/Swiss-Prot for PSTPIP2 Gene
-
Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).
Additional gene information for PSTPIP2 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSTPIP2 Gene
Genomics for PSTPIP2 Gene
GeneHancer (GH) Regulatory Elements for PSTPIP2 Gene
Promoters and enhancers for PSTPIP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PSTPIP2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PSTPIP2 Gene
Genomic Locations for PSTPIP2 Gene
- chr18:45,983,536-46,072,297
- (GRCh38/hg38)
- Size:
- 88,762 bases
- Orientation:
- Minus strand
- chr18:43,563,502-43,652,250
- (GRCh37/hg19)
Genomic View for PSTPIP2 Gene
Genes around PSTPIP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q21.1 by Ensembl
- 18q21.1|tdb7990 by Entrez Gene
- 18q21.1 by HGNC
PSTPIP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSTPIP2 Gene
Proteins for PSTPIP2 Gene
-
Protein details for PSTPIP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H939-PPIP2_HUMAN
- Recommended name:
- Proline-serine-threonine phosphatase-interacting protein 2
- Protein Accession:
- Q9H939
Protein attributes for PSTPIP2 Gene
- Size:
- 334 amino acids
- Molecular mass:
- 38858 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB14404.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for PSTPIP2 Gene
Post-translational modifications for PSTPIP2 Gene
- Phosphorylated on tyrosine.
Other Protein References for PSTPIP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
Abcam antibodies for PSTPIP2
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Protein Products
-
OriGene Purified Proteins for PSTPIP2
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- Compare Top PSTPIP2 Proteins
-
Quality Products:
- Search GeneTex for Proteins for PSTPIP2
-
Abcam proteins for PSTPIP2
Assay Products
No data available for DME Specific Peptides for PSTPIP2 Gene
Domains & Families for PSTPIP2 Gene
Gene Families for PSTPIP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PSTPIP2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PSTPIP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for PSTPIP2 Gene
Function for PSTPIP2 Gene
Molecular function for PSTPIP2 Gene
- UniProtKB/Swiss-Prot Function:
- Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).
Phenotypes From GWAS Catalog for PSTPIP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | IEA | -- |
Phenotypes for PSTPIP2 Gene
- MGI mutant phenotypes for PSTPIP2:
-
inferred from 3 alleles
- nervous system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- hearing/vestibular/ear phenotype
- integument phenotype
- hematopoietic system phenotype
- skeleton phenotype
- craniofacial phenotype
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for PSTPIP2:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for PSTPIP2 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for PSTPIP2
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- Applied Biological Materials CRISPR for PSTPIP2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSTPIP2
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miRNA for PSTPIP2 Gene
- miRTarBase miRNAs that target PSTPIP2
miRNA Products
- Search ViGene Biosciences for PSTPIP2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PSTPIP2
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-
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Clone Products
- Sino Biological Human cDNA Clone for PSTPIP2
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PSTPIP2 gene related products
- orf clones - Search results for available PSTPIP2 gene related products
- Applied Biological Materials Clones for PSTPIP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PSTPIP2
-
ViGene Biosciences adenoviral particle packaged cDNA for PSTPIP2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PSTPIP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PSTPIP2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSTPIP2 Gene
Localization for PSTPIP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PSTPIP2 Gene
- Cytoplasm. Membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| mitochondrion | 3 |
| nucleus | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
- Mitochondria (2)
- Nucleus (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IEA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for PSTPIP2 Gene
No Data Available
Interacting Proteins for PSTPIP2 Gene
Selected Interacting proteins:
Q9H939-PPIP2_HUMAN
ENSP00000387261
for PSTPIP2 Gene via
MINT
STRING
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007010 | cytoskeleton organization | IEA | -- |
| GO:0016477 | cell migration | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for PSTPIP2 Gene
Transcripts for PSTPIP2 Gene
mRNA/cDNA for PSTPIP2 Gene
- (4) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (46) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PSTPIP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PSTPIP2
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSTPIP2
- GenScript: Design CRISPR guide RNA sequences for PSTPIP2
miRNA Products
- Search ViGene Biosciences for PSTPIP2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PSTPIP2
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- genomics-online: shRNA clones - Search results for available PSTPIP2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PSTPIP2 gene
Clone Products
- Sino Biological Human cDNA Clone for PSTPIP2
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- VectorBuilder custom plasmid, inducible vectors for PSTPIP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSTPIP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PSTPIP2 gene related products
- orf clones - Search results for available PSTPIP2 gene related products
- Applied Biological Materials Clones for PSTPIP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PSTPIP2 Gene
mRNA differential expression in normal tissues according to GTEx for PSTPIP2 Gene
This gene is overexpressed in Whole Blood (x16.5) and Spleen (x7.5).
This gene is overexpressed in Peripheral blood mononuclear cells (34.1), Spleen (16.1), and Platelet (9.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSTPIP2 Gene
NURSA nuclear receptor signaling pathways regulating expression of PSTPIP2 Gene:
PSTPIP2SOURCE GeneReport for Unigene cluster for PSTPIP2 Gene:
Hs.567384Evidence on tissue expression from TISSUES for PSTPIP2 Gene
- Blood(2.2)
Primer Products
-
OriGene qPCR primer pairs for PSTPIP2
-
OriGene qPCR primer pairs and template standards for PSTPIP2
- genomics-online: primer clones - Search results for available PSTPIP2 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSTPIP2 Gene
Orthologs for PSTPIP2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PSTPIP2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | PSTPIP2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PSTPIP2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Pstpip2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pstpip2 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PSTPIP2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PSTPIP2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PSTPIP2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PSTPIP2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pstpip2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:ch211-251f6.4 33 |
|
||
| CU633857.1 34 |
|
OneToMany | |||
| PSTPIP2 (1 of 2) 34 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for PSTPIP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PSTPIP2 Gene
Variants for PSTPIP2 Gene
| SNP ID | Clin | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000103549 | -- | 46,044,891(-) | AAAAAA/AAAAAAA | genic_upstream_transcript_variant, intron_variant | |
| rs1000136214 | -- | 46,045,142(-) | A/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000158153 | -- | 45,995,235(-) | T/C | intron_variant | |
| rs1000196703 | -- | 45,989,485(-) | G/A | intron_variant | |
| rs1000204799 | -- | 46,018,546(-) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2717027 | CNV | deletion | 23290073 |
| esv2717030 | CNV | deletion | 23290073 |
| esv3642418 | CNV | gain | 21293372 |
| esv3642419 | CNV | loss | 21293372 |
| esv3642420 | CNV | gain | 21293372 |
| esv3642421 | CNV | loss | 21293372 |
| esv3642422 | CNV | gain | 21293372 |
| nsv2277 | CNV | deletion | 18451855 |
| nsv477286 | CNV | novel sequence insertion | 20440878 |
Residual Variation Intolerance Score:
38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.56;
82.47% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PSTPIP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PSTPIP2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSTPIP2 Gene
Disorders for PSTPIP2 Gene
Additional Disease Information for PSTPIP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PSTPIP2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSTPIP2 Gene
Publications for PSTPIP2 Gene
- Genetic susceptibility factors in a cohort of 38 patients with SAPHO syndrome: a study of PSTPIP2, NOD2, and LPIN2 genes. (PMID: 20032092) Hurtado-Nedelec M … Gérard B (The Journal of rheumatology 2010) 3 44 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase. (PMID: 9804817) Wu Y … Lasky LA (The Journal of biological chemistry 1998) 2 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for PSTPIP2 Gene
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- Invitrogen Antibodies for PSTPIP2
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- VectorBuilder custom plasmid, inducible vectors for PSTPIP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSTPIP2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 16 available PSTPIP2 Antibodies ranked by validation data
- Compare Top PSTPIP2 Antibodies
- antibodies-online: Search results for available PSTPIP2 related products ranked by validation data
- antibodies-online: Search results for 3 available PSTPIP2 Proteins ranked by validation data
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- Quality Products:
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- Horizon Cell Lines for PSTPIP2
- genomics-online: cdna clones - Search results for available PSTPIP2 gene related products
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Sources for PSTPIP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
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- (140) SNPedia
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- (148) abm
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- (153) DataMed
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- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew