Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PSRC1 Gene

Aliases for PSRC1 Gene

  • Proline And Serine Rich Coiled-Coil 1 2 3
  • Proline/Serine-Rich Coiled-Coil 1 2 3 5
  • Differential Display And Activated By P53 2 3
  • DDA3 3 4
  • P53-Regulated DDA3 3
  • FP3214 3

External Ids for PSRC1 Gene

Previous GeneCards Identifiers for PSRC1 Gene

  • GC01M109535
  • GC01M109624
  • GC01M109625
  • GC01M109822
  • GC01M107715

Summaries for PSRC1 Gene

Entrez Gene Summary for PSRC1 Gene

  • This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014]

GeneCards Summary for PSRC1 Gene

PSRC1 (Proline And Serine Rich Coiled-Coil 1) is a Protein Coding gene. GO annotations related to this gene include microtubule binding.

UniProtKB/Swiss-Prot for PSRC1 Gene

  • Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.

Gene Wiki entry for PSRC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSRC1 Gene

Genomics for PSRC1 Gene

Regulatory Elements for PSRC1 Gene

Promoters for PSRC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSRC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSRC1 Gene

Chromosome:
1
Start:
109,279,554 bp from pter
End:
109,283,186 bp from pter
Size:
3,633 bases
Orientation:
Minus strand

Genomic View for PSRC1 Gene

Genes around PSRC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSRC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSRC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSRC1 Gene

Proteins for PSRC1 Gene

  • Protein details for PSRC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PGN9-PSRC1_HUMAN
    Recommended name:
    Proline/serine-rich coiled-coil protein 1
    Protein Accession:
    Q6PGN9
    Secondary Accessions:
    • Q5T2Z3
    • Q6ZTI8
    • Q71MG3
    • Q9BV77

    Protein attributes for PSRC1 Gene

    Size:
    363 amino acids
    Molecular mass:
    38796 Da
    Quaternary structure:
    • Interacts with APC2 (By similarity). Interacts with KIF2A.

    Alternative splice isoforms for PSRC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSRC1 Gene

Proteomics data for PSRC1 Gene at MOPED

Post-translational modifications for PSRC1 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PSRC1

No data available for DME Specific Peptides for PSRC1 Gene

Domains & Families for PSRC1 Gene

Protein Domains for PSRC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PSRC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PGN9

UniProtKB/Swiss-Prot:

PSRC1_HUMAN :
  • Belongs to the PSRC1 family.
Family:
  • Belongs to the PSRC1 family.
genes like me logo Genes that share domains with PSRC1: view

No data available for Gene Families for PSRC1 Gene

Function for PSRC1 Gene

Molecular function for PSRC1 Gene

UniProtKB/Swiss-Prot Function:
Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.

Phenotypes for PSRC1 Gene

GenomeRNAi human phenotypes for PSRC1:
genes like me logo Genes that share phenotypes with PSRC1: view

Animal Model Products

CRISPR Products

miRNA for PSRC1 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSRC1 Gene

Localization for PSRC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSRC1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSRC1 Gene COMPARTMENTS Subcellular localization image for PSRC1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 4
extracellular 2

Gene Ontology (GO) - Cellular Components for PSRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,ISS 12427559
GO:0005819 spindle IEA,ISS 12427559
genes like me logo Genes that share ontologies with PSRC1: view

Pathways & Interactions for PSRC1 Gene

SuperPathways for PSRC1 Gene

No Data Available

Interacting Proteins for PSRC1 Gene

Gene Ontology (GO) - Biological Process for PSRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation IEA,ISS 12427559
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA,ISS 12427559
GO:0051301 cell division IEA --
GO:0060236 regulation of mitotic spindle organization IDA 18411309
genes like me logo Genes that share ontologies with PSRC1: view

No data available for Pathways by source and SIGNOR curated interactions for PSRC1 Gene

Drugs & Compounds for PSRC1 Gene

No Compound Related Data Available

Transcripts for PSRC1 Gene

Unigene Clusters for PSRC1 Gene

Proline/serine-rich coiled-coil 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSRC1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - -
SP10: - - - - -
SP11: -
SP12: - - - -
SP13: - - - - -
SP14: - - - -
SP15: - - -

ExUns: 8d · 8e ^ 9 ^ 10a · 10b · 10c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for PSRC1 Gene

GeneLoc Exon Structure for
PSRC1
ECgene alternative splicing isoforms for
PSRC1

Expression for PSRC1 Gene

mRNA expression in normal human tissues for PSRC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSRC1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.7), Brain - Substantia nigra (x4.8), and Brain - Hippocampus (x4.3).

Protein differential expression in normal tissues from HIPED for PSRC1 Gene

This gene is overexpressed in Frontal cortex (43.9) and Retina (25.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSRC1 Gene



SOURCE GeneReport for Unigene cluster for PSRC1 Gene Hs.405925

mRNA Expression by UniProt/SwissProt for PSRC1 Gene

Q6PGN9-PSRC1_HUMAN
Tissue specificity: Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetal thymus. Not detected in adult skeletal muscle.
genes like me logo Genes that share expression patterns with PSRC1: view

Protein tissue co-expression partners for PSRC1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PSRC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSRC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSRC1 35
  • 99.7 (n)
  • 99.1 (a)
PSRC1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSRC1 36
  • 85 (a)
OneToOne
PSRC1 35
  • 85.89 (n)
  • 84.66 (a)
dog
(Canis familiaris)
Mammalia PSRC1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psrc1 36
  • 71 (a)
OneToOne
Psrc1 16
Psrc1 35
  • 78.27 (n)
  • 73.04 (a)
oppossum
(Monodelphis domestica)
Mammalia PSRC1 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSRC1 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psrc1 35
  • 79 (n)
  • 73.35 (a)
Species with no ortholog for PSRC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSRC1 Gene

ENSEMBL:
Gene Tree for PSRC1 (if available)
TreeFam:
Gene Tree for PSRC1 (if available)

Paralogs for PSRC1 Gene

No data available for Paralogs for PSRC1 Gene

Variants for PSRC1 Gene

Sequence variations from dbSNP and Humsavar for PSRC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs34863121 - 109,280,836(+) CTTTT(A/C/T)GAGTT reference, synonymous-codon, missense
rs10410 -- 109,279,782(-) TTCCA(C/T)GTGAG utr-variant-3-prime
rs14000 -- 109,279,887(+) TCTCA(C/T)CTTCT utr-variant-3-prime
rs1277930 -- 109,279,521(+) aaaaa(A/G)agaaa downstream-variant-500B
rs6669669 -- 109,283,218(+) TGATT(A/G)GTGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PSRC1 Gene

Variant ID Type Subtype PubMed ID
nsv517354 CNV Loss 19592680
esv2716006 CNV Deletion 23290073
esv2716017 CNV Deletion 23290073

Variation tolerance for PSRC1 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.62; 45.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSRC1 Gene

HapMap Linkage Disequilibrium report
PSRC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSRC1 Gene

Disorders for PSRC1 Gene

Relevant External Links for PSRC1

Genetic Association Database (GAD)
PSRC1
Human Genome Epidemiology (HuGE) Navigator
PSRC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSRC1

No disorders were found for PSRC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSRC1 Gene

Publications for PSRC1 Gene

  1. Cloning and characterization of human and mouse DDA3 genes. (PMID: 12427559) Lo P.-K. … Wang F.-F. (Biochim. Biophys. Acta 2002) 2 3 4 67
  2. Identification of a novel mouse p53 target gene DDA3. (PMID: 10618717) Lo P.K. … Wang F.F. (Oncogene 1999) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. DDA3 targets Cep290 into the centrosome to regulate spindle positioning. (PMID: 25998387) Song H. … Jang C.Y. (Biochem. Biophys. Res. Commun. 2015) 3
  5. CELSR2-PSRC1-SORT1 gene expression and association with coronary artery disease and plasma lipid levels in an Asian Indian cohort. (PMID: 24674750) Arvind P. … Shanker J. (J Cardiol 2014) 3

Products for PSRC1 Gene

Sources for PSRC1 Gene

Back to Top

Content