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Aliases for PSRC1 Gene

Aliases for PSRC1 Gene

  • Proline And Serine Rich Coiled-Coil 1 2 3 5
  • Differential Display And Activated By P53 2 3
  • Proline/Serine-Rich Coiled-Coil 1 2 3
  • DDA3 3 4
  • Proline/Serine-Rich Coiled-Coil Protein 1 3
  • P53-Regulated DDA3 3
  • FP3214 3

External Ids for PSRC1 Gene

Previous GeneCards Identifiers for PSRC1 Gene

  • GC01M109535
  • GC01M109624
  • GC01M109625
  • GC01M109822
  • GC01M107715

Summaries for PSRC1 Gene

Entrez Gene Summary for PSRC1 Gene

  • This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014]

GeneCards Summary for PSRC1 Gene

PSRC1 (Proline And Serine Rich Coiled-Coil 1) is a Protein Coding gene. Among its related pathways are Aryl Hydrocarbon Receptor. GO annotations related to this gene include microtubule binding.

UniProtKB/Swiss-Prot for PSRC1 Gene

  • Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.

Gene Wiki entry for PSRC1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSRC1 Gene

Genomics for PSRC1 Gene

Regulatory Elements for PSRC1 Gene

Enhancers for PSRC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G109281 1.4 ENCODE dbSUPER 19.7 +0.2 194 3.0 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ZNF610 PSRC1 AMIGO1 ATXN7L2 PIR46363
GH01G109389 2 FANTOM5 Ensembl ENCODE dbSUPER 13.6 -111.3 -111273 10.7 CREB3L1 MLX AGO1 ZFP64 DMAP1 SLC30A9 SP3 NFYC TBX21 MEF2D SYPL2 PSRC1 MYBPHL SARS AMIGO1 ATXN7L2 SORT1 TMEM167B GSTM3 GNAI3
GH01G109272 2.1 VISTA Ensembl ENCODE dbSUPER 8 +7.3 7342 6.3 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 CELSR2 PRPF38B SORT1 ENSG00000258634 RPL17P7 PSRC1 RPL7P8 PIR46363
GH01G109382 1.4 Ensembl ENCODE dbSUPER 10.9 -100.6 -100561 2.3 ELF3 ATF1 FOXA2 CBX3 ARID4B TCF12 ZNF121 EGR1 ZSCAN5C SCRT2 SYPL2 MYBPHL PSRC1 SORT1 GC01P109313
GH01G109213 1.4 ENCODE dbSUPER 10.2 +68.1 68130 3.6 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GNAI3 SORT1 ENSG00000258634 PSRC1 MYBPHL CELSR2 GC01M109214 GC01P109222
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSRC1 on UCSC Golden Path with GeneCards custom track

Promoters for PSRC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000011060 -14 1201 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 KLF13

Genomic Location for PSRC1 Gene

Chromosome:
1
Start:
109,279,554 bp from pter
End:
109,283,186 bp from pter
Size:
3,633 bases
Orientation:
Minus strand

Genomic View for PSRC1 Gene

Genes around PSRC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSRC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSRC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSRC1 Gene

Proteins for PSRC1 Gene

  • Protein details for PSRC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PGN9-PSRC1_HUMAN
    Recommended name:
    Proline/serine-rich coiled-coil protein 1
    Protein Accession:
    Q6PGN9
    Secondary Accessions:
    • Q5T2Z3
    • Q6ZTI8
    • Q71MG3
    • Q9BV77

    Protein attributes for PSRC1 Gene

    Size:
    363 amino acids
    Molecular mass:
    38796 Da
    Quaternary structure:
    • Interacts with APC2 (By similarity). Interacts with KIF2A (PubMed:18411309). Interacts with ANKRD53; recruits ANKRD53 to the spindle during mitosis (PubMed:26820536).

    Alternative splice isoforms for PSRC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSRC1 Gene

Post-translational modifications for PSRC1 Gene

No data available for DME Specific Peptides for PSRC1 Gene

Domains & Families for PSRC1 Gene

Protein Domains for PSRC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PSRC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PGN9

UniProtKB/Swiss-Prot:

PSRC1_HUMAN :
  • Belongs to the PSRC1 family.
Family:
  • Belongs to the PSRC1 family.
genes like me logo Genes that share domains with PSRC1: view

No data available for Gene Families for PSRC1 Gene

Function for PSRC1 Gene

Molecular function for PSRC1 Gene

UniProtKB/Swiss-Prot Function:
Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.

Gene Ontology (GO) - Molecular Function for PSRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18411309
GO:0008017 microtubule binding ISS 12427559
genes like me logo Genes that share ontologies with PSRC1: view

Phenotypes for PSRC1 Gene

GenomeRNAi human phenotypes for PSRC1:
genes like me logo Genes that share phenotypes with PSRC1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PSRC1

CRISPR Products

miRNA for PSRC1 Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSRC1 Gene

Localization for PSRC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSRC1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSRC1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 1

Gene Ontology (GO) - Cellular Components for PSRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 colocalizes_with spindle pole IDA 18411309
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm ISS 12427559
GO:0005819 spindle ISS 12427559
GO:0005829 cytosol IDA 18411309
genes like me logo Genes that share ontologies with PSRC1: view

Pathways & Interactions for PSRC1 Gene

SuperPathways for PSRC1 Gene

SuperPathway Contained pathways
1 Aryl Hydrocarbon Receptor
genes like me logo Genes that share pathways with PSRC1: view

Pathways by source for PSRC1 Gene

1 BioSystems pathway for PSRC1 Gene

Gene Ontology (GO) - Biological Process for PSRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation ISS 12427559
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007080 mitotic metaphase plate congression IDA 18411309
GO:0009987 cellular process IEA --
genes like me logo Genes that share ontologies with PSRC1: view

No data available for SIGNOR curated interactions for PSRC1 Gene

Drugs & Compounds for PSRC1 Gene

No Compound Related Data Available

Transcripts for PSRC1 Gene

Unigene Clusters for PSRC1 Gene

Proline/serine-rich coiled-coil 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSRC1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - -
SP10: - - - - -
SP11: -
SP12: - - - -
SP13: - - - - -
SP14: - - - -
SP15: - - -

ExUns: 8d · 8e ^ 9 ^ 10a · 10b · 10c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for PSRC1 Gene

GeneLoc Exon Structure for
PSRC1
ECgene alternative splicing isoforms for
PSRC1

Expression for PSRC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSRC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSRC1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.7), Brain - Substantia nigra (x4.8), and Brain - Hippocampus (x4.3).

Protein differential expression in normal tissues from HIPED for PSRC1 Gene

This gene is overexpressed in Frontal cortex (43.9) and Retina (25.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSRC1 Gene



Protein tissue co-expression partners for PSRC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSRC1 Gene:

PSRC1

SOURCE GeneReport for Unigene cluster for PSRC1 Gene:

Hs.405925

mRNA Expression by UniProt/SwissProt for PSRC1 Gene:

Q6PGN9-PSRC1_HUMAN
Tissue specificity: Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetal thymus. Not detected in adult skeletal muscle.

Evidence on tissue expression from TISSUES for PSRC1 Gene

  • Nervous system(4.8)
  • Skin(4.6)
genes like me logo Genes that share expression patterns with PSRC1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PSRC1 Gene

Orthologs for PSRC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSRC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSRC1 34 35
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia PSRC1 35
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSRC1 34 35
  • 85.89 (n)
rat
(Rattus norvegicus)
Mammalia Psrc1 34
  • 79 (n)
mouse
(Mus musculus)
Mammalia Psrc1 34 16 35
  • 78.27 (n)
oppossum
(Monodelphis domestica)
Mammalia PSRC1 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSRC1 35
  • 42 (a)
OneToOne
Species where no ortholog for PSRC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSRC1 Gene

ENSEMBL:
Gene Tree for PSRC1 (if available)
TreeFam:
Gene Tree for PSRC1 (if available)

Paralogs for PSRC1 Gene

No data available for Paralogs for PSRC1 Gene

Variants for PSRC1 Gene

Sequence variations from dbSNP and Humsavar for PSRC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000728297 -- 109,285,016(+) AGGCA(C/G)AGCTT upstream-variant-2KB
rs1001838245 -- 109,283,071(+) CAGCC(C/T)ACCCT intron-variant, utr-variant-5-prime
rs1001954216 -- 109,282,749(+) GAAAC(C/G)ATACC intron-variant, utr-variant-5-prime
rs1002839747 -- 109,284,559(+) GGAGT(A/G)GGCAT upstream-variant-2KB
rs1002905550 -- 109,283,276(+) GGGGG(A/C)TGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PSRC1 Gene

Variant ID Type Subtype PubMed ID
esv2716006 CNV deletion 23290073
esv2716017 CNV deletion 23290073
nsv1012267 CNV gain 25217958
nsv517354 CNV loss 19592680

Variation tolerance for PSRC1 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.62; 45.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSRC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSRC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSRC1 Gene

Disorders for PSRC1 Gene

Relevant External Links for PSRC1

Genetic Association Database (GAD)
PSRC1
Human Genome Epidemiology (HuGE) Navigator
PSRC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSRC1

No disorders were found for PSRC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSRC1 Gene

Publications for PSRC1 Gene

  1. Cloning and characterization of human and mouse DDA3 genes. (PMID: 12427559) Lo P.-K. … Wang F.-F. (Biochim. Biophys. Acta 2002) 2 3 4 64
  2. ANKRD53 interacts with DDA3 and regulates chromosome integrity during mitosis. (PMID: 26820536) Kim S. … Jang C.Y. (Biochem. Biophys. Res. Commun. 2016) 3 4 64
  3. Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. (PMID: 21909109) Kim Y.J. … Cho Y.S. (Nat. Genet. 2011) 3 46 64
  4. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PMID: 21378990) Schunkert H. … Samani N.J. (Nat. Genet. 2011) 3 46 64
  5. Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study. (PMID: 20442857) Suchindran S. … McCarthy J.J. (PLoS Genet. 2010) 3 46 64

Products for PSRC1 Gene

Sources for PSRC1 Gene

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