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PSPN Gene

protein-coding   GIFtS: 56
GCID: GC19M006375

Persephin

  See PSPN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
persephin1 2
PSP2 3

External Ids:    HGNC: 95791   Entrez Gene: 56232   Ensembl: ENSG000001256507   OMIM: 6029215   UniProtKB: O605423   

Export aliases for PSPN gene to outside databases

Previous GC identifers: GC19M006469 GC19M006315 GC19M006326 GC19M006135


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PSPN Gene:
The protein encoded by this gene is a neurotrophic factor, belonging to the GDNF family. Neurotrophic factors are
important for the proper development and maintenance of the nervous system. These factors promote neuronal
survival and can prevent the neuronal degeneration associated with injury, toxin exposure, or neurodegenerative
disease. The encoded protein has amino acid similarity to its other family members, glial cell line-derived
neurotrophic factor and neurturin. This gene product promotes the survival of ventral midbrain dopaminergic
neurons in culture and prevents their degeneration after 6-hydroxydopamine treatment in vivo. (provided by
RefSeq, Jul 2008)

GeneCards Summary for PSPN Gene:
PSPN (persephin) is a protein-coding gene. Diseases associated with PSPN include hirschsprung's disease, and parkinson's disease. GO annotations related to this gene include growth factor activity and receptor binding. An important paralog of this gene is GDNF.

UniProtKB/Swiss-Prot: PSPN_HUMAN, O60542
Function: Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the PSPN gene promoter:
         AP-2alpha isoform 3   AML1a   SREBP-1c   NRSF form 1   MyoD   NRSF form 2   SREBP-1b   SREBP-1a   NRF-2   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSPN promoter sequence
   Search Chromatin IP Primers for PSPN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSPN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

PSPN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSPN gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M006375:  view genomic region     (about GC identifiers)

Start:
6,375,159 bp from pter      End:
6,379,069 bp from pter
Size:
3,911 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PSPN_HUMAN, O60542 (See protein sequence)
Recommended Name: Persephin precursor  
Size: 156 amino acids; 16600 Da
Subunit: Homodimer; disulfide-linked (By similarity)

Explore the universe of human proteins at neXtProt for PSPN: NX_O60542

Explore proteomics data for PSPN at MOPED


See PSPN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_004149.1  
ENSEMBL proteins: 
 ENSP00000469884   ENSP00000245810  
Reactome Protein details: O60542

PSPN Human Recombinant Protein Products:

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OriGene Protein Over-expression Lysate for PSPN
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Novus Biologicals PSPN Lysate
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Cloud-Clone Corp. Proteins for PSPN

 
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PSPN Antibody Products:

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Novus Biologicals PSPN Antibody
Abcam antibodies for PSPN
Cloud-Clone Corp. Antibodies for PSPN
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LSBio Antibodies in human, mouse, rat for PSPN

PSPN Assay Products:

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Cloud-Clone Corp. ELISAs for PSPN
Cloud-Clone Corp. CLIAs for PSPN
Search eBioscience for ELISAs for PSPN 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands

1 InterPro protein domain:
 IPR001839 TGF-b_C

Graphical View of Domain Structure for InterPro Entry O60542

ProtoNet protein and cluster: O60542

2 Blocks protein domains:
IPB001839 Transforming growth factor beta (TGFb)
IPB002400 Growth factor cystine knot superfamily signature


UniProtKB/Swiss-Prot: PSPN_HUMAN, O60542
Similarity: Belongs to the TGF-beta family. GDNF subfamily


Find genes that share domains with PSPN           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: PSPN_HUMAN, O60542
Function: Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons

     Genatlas biochemistry entry for PSPN:
persephin,neurotrophic factor,related to GDNF and neurturin,involved in the survival of several neuronal cell
types from the central nervous system

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005102receptor binding TAS9491986
GO:0008083growth factor activity IEA--
     
Find genes that share ontologies with PSPN           About GenesLikeMe


Phenotypes:
     2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pspn):
 homeostasis/metabolism  nervous system 

Find genes that share phenotypes with PSPN           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Pspntm1Bjh for PSPN

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PSPN
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PSPN

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PSPN
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PSPN

miRNA
Products:
    
miRTarBase miRNAs that target PSPN:
hsa-mir-335-5p (MIRT017516)

Block miRNA regulation of human, mouse, rat PSPN using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate PSPN
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat PSPN

Gene Editing
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OriGene ORF clones in mouse, rat for PSPN
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GenScript: all cDNA clones in your preferred vector: PSPN (NM_004158)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSPN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSPN

Cell Line
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSPN


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
PSPN_HUMAN, O60542: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
cytosol1
endoplasmic reticulum1
lysosome1
mitochondrion1
nucleus1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IEA--

Find genes that share ontologies with PSPN           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for PSPN About    
See pathways by source

SuperPathContained pathways About
1Development EGFR signaling pathway
Development GDNF family signaling0.45
GDNF-Family Ligands and Receptor Interactions0.41
2L1CAM interactions
Axon guidance0.63
Developmental Biology0.63
3NCAM signaling for neurite out-growth
NCAM1 interactions0.59
NCAM signaling for neurite out-growth0.59


Find genes that share SuperPaths with PSPN           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PSPN
    GDNF-Family Ligands and Receptor Interactions

1 GeneGo (Thomson Reuters) Pathway for PSPN
    Development GDNF family signaling

1 Reactome Pathway for PSPN
    NCAM1 interactions


    Pathway & Disease-focused RT2 Profiler PCR Arrays including PSPN: 
          Growth Factors in human mouse rat
          Neurotrophins & Receptors in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for PSPN

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for PSPN (O605423 ENSP000002458104) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
GFRA4Q9GZZ73, ENSP000003134234I2D: score=2 STRING: ENSP00000313423
ARTNENSP000003919984STRING: ENSP00000391998
GDNFENSP000003171454STRING: ENSP00000317145
GFRA1ENSP000003937254STRING: ENSP00000393725
NCAM1ENSP000003184724STRING: ENSP00000318472
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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001658branching involved in ureteric bud morphogenesis IEA--
GO:0007399nervous system development TAS9491986
GO:0007411axon guidance TAS--
GO:0007417central nervous system development TAS9491986

Find genes that share ontologies with PSPN           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for PSPN

4 Novoseek inferred chemical compound relationships for PSPN gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine 51.8 5 9576965 (1), 9740802 (1), 10484767 (1), 11222636 (1) (see all 5)
6-hydroxydopamine 44 2 9491986 (1), 11043566 (1)
dopamine 14.2 2 12953054 (1)
glutamate 0 2 10356295 (1), 10686085 (1)



Find genes that share compounds with PSPN           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for PSPN gene: 
NM_004158.2  

Unigene Cluster for PSPN:

Persephin
Hs.248159  [show with all ESTs]
Unigene Representative Sequence: BE799721
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000597721 ENST00000245810(uc010xja.2)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat PSPN using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate PSPN
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for PSPN
Predesigned siRNA for gene silencing in human, mouse, rat PSPN
Clone
Products:
     
OriGene clones in human, mouse for PSPN (see all 5)
OriGene ORF clones in mouse, rat for PSPN
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: PSPN (NM_004158)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSPN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSPN
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for PSPN
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PSPN
  QuantiTect SYBR Green Assays in human, mouse, rat PSPN
  QuantiFast Probe-based Assays in human, mouse, rat PSPN

Additional mRNA sequence: 

AF040962.1 BC143894.1 

3 DOTS entries:

DT.92035523  DT.97861638  DT.95213128 

Selected AceView cDNA sequences (see all 302):

CA438420 BQ070397 AW007716 BI822877 BQ962892 BU617787 BM818653 AK055490 
BQ644620 BQ884087 AA381284 AV709705 BM709285 BM728178 AI827551 BQ925302 
AW025443 BQ350170 BF081906 AI394578 BQ423837 BG170718 BM709655 BF792427 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PSPN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCTGGCGCT
PSPN Expression
About this image

PSPN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

PSPN Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.248159
    Pathway & Disease-focused RT2 Profiler PCR Arrays including PSPN: 
          Growth Factors in human mouse rat
          Neurotrophins & Receptors in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for PSPN
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PSPN
QuantiTect SYBR Green Assays in human, mouse, rat PSPN
QuantiFast Probe-based Assays in human, mouse, rat PSPN
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSPN

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for PSPN gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Pspn1 , 5 persephin1, 5 73.76(n)1
64.52(a)1
  17 (29.62 cM)5
191971  NM_008954.21  NP_032980.21 
 569994575 
lizard
(Anolis carolinensis)
Reptilia PSPN6
persephin
52(a)
1 ↔ 1
2(76458837-76459112)


ENSEMBL Gene Tree for PSPN (if available)
TreeFam Gene Tree for PSPN (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for PSPN gene
GDNF2  ARTN2  NRTN2  
2 SIMAP similar genes for PSPN using alignment to 2 protein entries:     PSPN_HUMAN (see all proteins):
NRTN    ARTN

Find genes that share paralogs with PSPN           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for PSPN (see all 80)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1153672971,2
C,F--6375785(+) ACGGGC/TATCGG 2 T A mis11Minor allele frequency- T:0.00NA 4474
rs2006059331,2
--6375789(+) GCATCA/GGGGCC 2 P syn10--------
rs1426437861,2
C,F--6375793(+) CGGGGC/ACCCAG 2 /G /V mis11Minor allele frequency- A:0.00NA 4466
rs1997318841,2
C--6375815(+) CTGCAG/AGGACA 2 /L syn11Minor allele frequency- A:0.00EU 1081
rs23041981,2
C,F,A,H--6375831(+) AGCAGG/AGAGCC 2 /S syn1 ese326Minor allele frequency- A:0.38EA NS WA NA CSA EU 10086
rs2020157301,2
--6375852(+) TTCCCG/TACGGC 2 V syn10--------
rs1388269271,2
C--6375854(+) CCCTAC/TGGCCA 2 I V mis10--------
rs1873506321,2
C--6375866(+) TGTGAC/TGGGCA 1 -- us2k11Minor allele frequency- T:0.00EU 1127
rs767578141,2
F--6375996(+) CCCTCG/AAATCC 1 -- us2k11Minor allele frequency- A:0.12NA 120
rs104016451,2
C,F,H--6376014(+) TGCTCC/ATTCTG 1 -- us2k110Minor allele frequency- A:0.05NS NA WA 1322

HapMap Linkage Disequilibrium report for PSPN (6375159 - 6379069 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for PSPN:    About this table    
Variant IDTypeSubtypePubMed ID
nsv513757CNV Insertion21212237
dgv3699n71CNV Loss21882294
nsv910916CNV Loss21882294
dgv3700n71CNV Loss21882294
nsv910911CNV Loss21882294
dgv3698n71CNV Loss21882294

Human Gene Mutation Database (HGMD): PSPN
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing PSPN
DNA2.0 Custom Variant and Variant Library Synthesis for PSPN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 602921    OMIM disorders: --

2 diseases for PSPN:    
About MalaCards
hirschsprung's disease    parkinson's disease

1 disease from the University of Copenhagen DISEASES database for PSPN:
Hirschsprung's disease

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4 Novoseek inferred disease relationships for PSPN gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
hirschsprung disease 63.8 1 18970938 (1)
neurodegenerative diseases 34.8 1 10652334 (1)
parkinson disease 11.2 2 20350599 (2)
tumors 5.27 1 12679485 (1)

Genetic Association Database (GAD): PSPN
Human Genome Epidemiology (HuGE) Navigator: PSPN (1 document)

Export disorders for PSPN gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for PSPN gene, integrated from 10 sources (see all 48):
(articles sorted by number of sources associating them with PSPN)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Persephin, a novel neurotrophic factor related to GDNF and neurturin. (PubMed id 9491986)1, 2, 9 Milbrandt J.... Johnson E.M. (Neuron 1998)
  2. Assignment of persephin (PSPN), a human neurotrophic factor, to chromosome 19p13.3 by radiation hybrid mapping and somatic cell hybrid PCR. (PubMed id 10072588)1, 3, 9 Chadwick B.P....Slaugenhaupt S.A. (Cytogenet. Cell Genet. 1998)
  3. Polymorphisms in the genes encoding the 4 RET ligands, GDNF, NTN, ARTN, PSPN, and susceptibility to Hirschsprung disease. (PubMed id 18970938)1, 4, 9 Fernandez R.M....Borrego S. (J. Pediatr. Surg. 2008)
  4. GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin. (PubMed id 9740802)1, 9 Enokido Y....Davies A.M. (Curr. Biol. 1998)
  5. Human glial cell line-derived neurotrophic factor receptor alpha4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells. (PubMed id 11116144)1, 9 Lindahl M.... Saarma M. (J. Biol. Chem. 2001)
  6. Neurturin, persephin, and artemin in the human pre- and full-term newborn and adult hippocampus and fascia dentata. (PubMed id 15829225)1, 9 Quartu M....Del Fiacco M. (Brain Res. 2005)
  7. Persephin signaling through GFRalpha1: the potential for the treatment of Parkinson's disease. (PubMed id 20350599)1, 9 Sidorova Y.A....Bespalov M.M. (Mol. Cell. Neurosci. 2010)
  8. GDNF, RET and GFRalpha-1-3 mRNA expression in the developing human spinal cord and ganglia. (PubMed id 10380959)1, 9 Widenfalk J....Spenger C. (Neuroreport 1999)
  9. PSPN/GFRalpha4 has a significantly weaker capacity than GDNF/GFRalpha1 to recruit RET to rafts, but promotes neuronal survival and neurite outgrowth. (PubMed id 15225646)1, 9 Yang J....Saarma M. (FEBS Lett. 2004)
  10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5623 HGNC: 9579 AceView: GTF2F1andPSPN Ensembl:ENSG00000125650 euGenes: HUgn5623
ECgene: PSPN H-InvDB: PSPN

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for PSPN Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for PSPN gene:
Search GeneIP for patents involving PSPN

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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