External Ids for PSPN Gene
Previous GeneCards Identifiers for PSPN Gene
The protein encoded by this gene is a neurotrophic factor, belonging to the GDNF family. Neurotrophic factors are important for the proper development and maintenance of the nervous system. These factors promote neuronal survival and can prevent the neuronal degeneration associated with injury, toxin exposure, or neurodegenerative disease. The encoded protein has amino acid similarity to its other family members, glial cell line-derived neurotrophic factor and neurturin. This gene product promotes the survival of ventral midbrain dopaminergic neurons in culture and prevents their degeneration after 6-hydroxydopamine treatment in vivo. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSPN Gene
PSPN (Persephin) is a Protein Coding gene. Diseases associated with PSPN include Hirschsprung Disease 1 and Colonic Disease. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Developmental Biology. GO annotations related to this gene include receptor binding and growth factor activity. An important paralog of this gene is GDNF.
UniProtKB/Swiss-Prot for PSPN Gene
Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.