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Aliases for PSPN Gene

Aliases for PSPN Gene

  • Persephin 2 3
  • PSP 3 4

External Ids for PSPN Gene

Summaries for PSPN Gene

Entrez Gene Summary for PSPN Gene

  • The protein encoded by this gene is a neurotrophic factor, belonging to the GDNF family. Neurotrophic factors are important for the proper development and maintenance of the nervous system. These factors promote neuronal survival and can prevent the neuronal degeneration associated with injury, toxin exposure, or neurodegenerative disease. The encoded protein has amino acid similarity to its other family members, glial cell line-derived neurotrophic factor and neurturin. This gene product promotes the survival of ventral midbrain dopaminergic neurons in culture and prevents their degeneration after 6-hydroxydopamine treatment in vivo. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSPN Gene

PSPN (Persephin) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include receptor binding and growth factor activity. An important paralog of this gene is NRTN.

UniProtKB/Swiss-Prot for PSPN Gene

  • Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSPN Gene

Genomics for PSPN Gene

Genomic Location for PSPN Gene

Start:
6,375,148 bp from pter
End:
6,379,058 bp from pter
Size:
3,911 bases
Orientation:
Minus strand

Genomic View for PSPN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSPN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSPN Gene

Proteins for PSPN Gene

  • Protein details for PSPN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60542-PSPN_HUMAN
    Recommended name:
    Persephin
    Protein Accession:
    O60542
    Secondary Accessions:

    Protein attributes for PSPN Gene

    Size:
    156 amino acids
    Molecular mass:
    16600 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

neXtProt entry for PSPN Gene

Proteomics data for PSPN Gene at MOPED

Post-translational modifications for PSPN Gene

No Post-translational modifications

Other Protein References for PSPN Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PSPN Gene

Domains for PSPN Gene

Gene Families for PSPN Gene

HGNC:

UniProtKB/Swiss-Prot:

PSPN_HUMAN
Family:
  • Belongs to the TGF-beta family. GDNF subfamily.:
    • O60542
genes like me logo Genes that share domains with PSPN: view

Function for PSPN Gene

Molecular function for PSPN Gene

GENATLAS Biochemistry: persephin,neurotrophic factor,related to GDNF and neurturin,involved in the survival of several neuronal cell types from the central nervous system
UniProtKB/Swiss-Prot Function: Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons

Gene Ontology (GO) - Molecular Function for PSPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 9491986
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with PSPN: view

Phenotypes for PSPN Gene

genes like me logo Genes that share phenotypes with PSPN: view

Animal Models for PSPN Gene

MGI Knock Outs for PSPN:

miRNA for PSPN Gene

miRTarBase miRNAs that target PSPN

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PSPN Gene

Localization for PSPN Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSPN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSPN Gene COMPARTMENTS Subcellular localization image for PSPN gene
Compartment Confidence
extracellular 5
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PSPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with PSPN: view

Pathways for PSPN Gene

genes like me logo Genes that share pathways with PSPN: view

Pathways by source for PSPN Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for PSPN Gene
1 Qiagen pathway for PSPN Gene

Gene Ontology (GO) - Biological Process for PSPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0007399 nervous system development TAS 9491986
GO:0007411 axon guidance TAS --
GO:0007417 central nervous system development TAS 9491986
genes like me logo Genes that share ontologies with PSPN: view

Compounds for PSPN Gene

(4) Novoseek inferred chemical compound relationships for PSPN Gene

Compound -log(P) Hits PubMed IDs
tyrosine 51.8 5
6-hydroxydopamine 44 2
dopamine 14.2 1
glutamate 0 2
genes like me logo Genes that share compounds with PSPN: view

Transcripts for PSPN Gene

mRNA/cDNA for PSPN Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(302) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PSPN Gene

Persephin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSPN Gene

No ASD Table

Relevant External Links for PSPN Gene

GeneLoc Exon Structure for
PSPN
ECgene alternative splicing isoforms for
PSPN

Expression for PSPN Gene

mRNA expression in normal human tissues for PSPN Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PSPN Gene

SOURCE GeneReport for Unigene cluster for PSPN Gene Hs.248159

genes like me logo Genes that share expressions with PSPN: view

Orthologs for PSPN Gene

This gene was present in the common ancestor of chordates.

Orthologs for PSPN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSPN 36
  • 98.5 (n)
  • 97.44 (a)
cow
(Bos Taurus)
Mammalia PSPN 36
  • 83.75 (n)
  • 81.82 (a)
PSPN 37
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSPN 36
  • 82 (n)
  • 76.67 (a)
PSPN 37
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pspn 36
  • 73.76 (n)
  • 64.52 (a)
Pspn 16
Pspn 37
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSPN 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pspn 36
  • 73.98 (n)
  • 67.1 (a)
lizard
(Anolis carolinensis)
Reptilia PSPN 37
  • 52 (a)
OneToOne
Species with no ortholog for PSPN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSPN Gene

ENSEMBL:
Gene Tree for PSPN (if available)
TreeFam:
Gene Tree for PSPN (if available)

Paralogs for PSPN Gene

Paralogs for PSPN Gene

Selected SIMAP similar genes for PSPN Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PSPN: view

Variants for PSPN Gene

Sequence variations from dbSNP and Humsavar for PSPN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs869918 -- 6,376,711(-) CTGCC(C/T)TACAC upstream-variant-2KB
rs2304198 -- 6,375,820(+) AGCAG(A/G)GAGCC reference, synonymous-codon
rs3810228 -- 6,376,764(+) TTGTC(C/T)GAAGG upstream-variant-2KB
rs7247913 -- 6,377,413(+) CTggc(A/C/G)gggcc upstream-variant-2KB
rs10401645 -- 6,376,003(+) TGCTC(A/C)TTCTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PSPN Gene

Variant ID Type Subtype PubMed ID
nsv910911 CNV Loss 21882294
dgv3698n71 CNV Loss 21882294
nsv910916 CNV Loss 21882294
dgv3699n71 CNV Loss 21882294
dgv3700n71 CNV Loss 21882294
nsv513757 CNV Insertion 21212237

Relevant External Links for PSPN Gene

HapMap Linkage Disequilibrium report
PSPN
Human Gene Mutation Database (HGMD)
PSPN

Disorders for PSPN Gene

(1) University of Copenhagen DISEASES for PSPN Gene

(4) Novoseek inferred disease relationships for PSPN Gene

Disease -log(P) Hits PubMed IDs
hirschsprung disease 63.8 1
neurodegenerative diseases 34.8 1
parkinson disease 11.2 2
tumors 5.27 1

Relevant External Links for PSPN

Genetic Association Database (GAD)
PSPN
Human Genome Epidemiology (HuGE) Navigator
PSPN
genes like me logo Genes that share disorders with PSPN: view

No data available for UniProtKB/Swiss-Prot for PSPN Gene

Publications for PSPN Gene

  1. Persephin, a novel neurotrophic factor related to GDNF and neurturin. (PMID: 9491986) Milbrandt J. … Johnson E.M. (Neuron 1998) 3 4 23
  2. Assignment of persephin (PSPN), a human neurotrophic factor, to chromosome 19p13.3 by radiation hybrid mapping and somatic cell hybrid PCR. (PMID: 10072588) Chadwick B.P. … Slaugenhaupt S.A. (Cytogenet. Cell Genet. 1998) 2 3 23
  3. Polymorphisms in the genes encoding the 4 RET ligands, GDNF, NTN, ARTN, PSPN, and susceptibility to Hirschsprung disease. (PMID: 18970938) Fernandez R.M. … Borrego S. (J. Pediatr. Surg. 2008) 3 23 49
  4. Persephin signaling through GFRalpha1: the potential for the treatment of Parkinson's disease. (PMID: 20350599) Sidorova Y.A. … Bespalov M.M. (Mol. Cell. Neurosci. 2010) 3 23
  5. PSPN/GFRalpha4 has a significantly weaker capacity than GDNF/GFRalpha1 to recruit RET to rafts, but promotes neuronal survival and neurite outgrowth. (PMID: 15225646) Yang J. … Saarma M. (FEBS Lett. 2004) 3 23

Products for PSPN Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate PSPN
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for PSPN
    • Block miRNA regulation of PSPN using miScript Target Protectors

    Sources for PSPN Gene

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