External Ids for PSPN Gene
Previous GeneCards Identifiers for PSPN Gene
This gene encodes a secreted ligand of the GDNF (glial cell line-derived neurotrophic factor) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. This protein may play a role in cell death, and nervous system development and function. Elevated expression of this gene has been observed in oral squamous cell carcinoma. [provided by RefSeq, Aug 2016]
GeneCards Summary for PSPN Gene
PSPN (Persephin) is a Protein Coding gene. Diseases associated with PSPN include Hirschsprung Disease 1 and Colonic Disease. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include receptor binding and growth factor activity. An important paralog of this gene is NRTN.
UniProtKB/Swiss-Prot for PSPN Gene
Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.