Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PSPC1 Gene

protein-coding   GIFtS: 50
GCID: GC13M020249

paraspeckle component 1
  Search for PSPC1
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PSPC1    

Aliases
for PSPC1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Paraspeckle Component 11 2
PSP11 2 3 5
Paraspeckle Protein 12 3
FLJ109551

External Ids:    HGNC: 203201   Entrez Gene: 552692   Ensembl: ENSG000001213907   OMIM: 6124085   UniProtKB: Q8WXF13   
ORGUL members:         
NONCODE:n411720 n405986    

Export aliases for PSPC1 gene to outside databases

Previous GC identifers: GC13M019178 GC13M018046 GC13M018047 GC13M019146 GC13M001053


Summaries
for PSPC1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PSPC1:
This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing
speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding
RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product
of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression
via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally
active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II
transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript
variants. A related pseudogene, which is also located on chromosome 13, has been identified. (provided by RefSeq, Aug
2011)

UniProtKB/Swiss-Prot: PSPC1_HUMAN, Q8WXF1
Function: Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in
Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (By similarity). Together
with NONO, required for the formation of nuclear paraspeckles




Genomic Views
for PSPC1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PSPC1 gene promoter:
         E2F-3a   E2F-4   E2F-5   Pax-5   E2F-2   LCR-F1   Nkx5-1   CREB   Zic1   deltaCREB   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PSPC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSPC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.11   Ensembl cytogenetic band:  13q12.11   HGNC cytogenetic band: 13q11

PSPC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSPC1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M020249:  view genomic region     (about GC identifiers)

Start:
 20,248,896 bp from pter      End:
 20,357,142 bp from pter
Size:
 108,247 bases      Orientation:
 minus strand
ORGUL member locations:
Legend (see complete legend)

  • n405986
  • n411720
20248891 20303025 20357159 chr13

Proteins
for PSPC1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PSPC1_HUMAN, Q8WXF1 (See protein sequence)
Recommended Name: Paraspeckle component 1  
Size: 523 amino acids; 58744 Da
Subunit: Forms heterodimers with NONO; this involves formation of a coiled coil domain by helices from both proteins.
Found in a RNP complex with CAT2 transcribed nuclear RNA (CTN-RNA). Interaction with NONO is required for its
targeting to paraspeckles and perinucleolar caps. Interacts with SFPQ (By similarity)
Subcellular location: Nucleus, nucleolus. Nucleus matrix (By similarity). Cytoplasm (By similarity). Nucleus speckle.
Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes
with NONO and SFPQ in paraspeckles and perinucleolar caps in a RNA-dependent manner. May cycles between paraspeckles
and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps
Sequence caution: Sequence=BAA91924.1; Type=Erroneous termination; Positions=14; Note=Translated as Lys;
1 PDB 3D structure from and Proteopedia for PSPC1:
3SDE (3D)    
Secondary accessions: Q5JTQ3 Q8NCZ9 Q8WXE8 Q9NV36
Alternative splicing: 2 isoforms:  Q8WXF1-1   Q8WXF1-2   

Explore the universe of human proteins at neXtProt for PSPC1: NX_Q8WXF1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WXF1

    • PSPC1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001035879.1  
    ENSEMBL proteins: 
     ENSP00000436038   ENSP00000435921   ENSP00000343966   ENSP00000393069  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: PSPC1
    OriGene Custom Protein Services for PSPC1 
    GenScript Custom Purified and Recombinant Proteins Services for PSPC1
    Novus Biologicals PSPC1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PSPC1

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm ----
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0016363nuclear matrix IEA--


    PSPC1 for ontologies           About GeneDecksing



    PSPC1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PSPC1 
    GenScript Custom Superior Antibodies Services for PSPC1
    Novus Biologicals PSPC1 Antibody
    Search for Antibodies for PSPC1 at Abcam  
    Uscn Antibodies for PSPC1
    ThermoFisher Antibodies for PSPC1

    Assay Products for PSPC1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PSPC1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PSPC1

    Protein Domains /
    Families
    for PSPC1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PSPC1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR012975 NOPS
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q8WXF1

    ProtoNet protein and cluster: Q8WXF1

    2 Blocks protein families:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB012975 NOPS


    UniProtKB/Swiss-Prot: PSPC1_HUMAN, Q8WXF1
    Similarity: Belongs to the PSPC family
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Function
    for PSPC1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PSPC1_HUMAN, Q8WXF1
    Function: Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in
    Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (By similarity). Together
    with NONO, required for the formation of nuclear paraspeckles

    miRNA
    Products:            		 OriGene 3'-UTR Clone: PSPC1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSPC1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate PSPC1:
    hsa-miR-3910 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-548aa
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSPC1 (see all 7)
    OriGene shRNA RFP: PSPC1
    OriGene siRNA: PSPC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSPC1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PSPC1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSPC1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSPC1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PSPC1 (NM_001042414)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSPC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSPC1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PSPC1
    Search LifeMap BioReagents cell lines for PSPC1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSPC1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI16169070


    PSPC1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PSPC1:
     Decreased Wnt reporter activit 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Pspc1):
     behavior/neurological 

    PSPC1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PSPC1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PSPC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/26 Interacting proteins for PSPC1 (Q8WXF11, 2, 3 ENSP000003439664) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NONOQ152331, 3, ENSP000002760794EBI-1392258,EBI-350527 I2D: score=4 STRING: ENSP00000276079
    LRIF1Q5T3J32, 3MINT-65061 I2D: score=4 
    WBP4O755542, 3, ENSP000003688014MINT-73043 I2D: score=3 STRING: ENSP00000368801
    SFPQP232463, ENSP000003497484I2D: score=3 STRING: ENSP00000349748
    AGO3Q9H9G73, ENSP000003622874I2D: score=2 STRING: ENSP00000362287
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    PSPC1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PSPC1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PSPC1
    Search CenterWatch for drugs/clinical trials and news about PSPC1 

    Transcripts
    for PSPC1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PSPC1 gene: 
    NM_001042414.2  

    Unigene Cluster for PSPC1:

    Paraspeckle component 1
    Hs.213198  [show with all ESTs]
    Unigene Representative Sequence: NR_044998
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497722 ENST00000471658 ENST00000492741 ENST00000338910(uc021rgx.1)
    ENST00000427943

    miRNA
    Products:             		 OriGene 3'-UTR Clone: PSPC1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSPC1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate PSPC1:
    hsa-miR-3910 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-548aa
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSPC1 (see all 7)
    OriGene shRNA RFP: PSPC1
    OriGene siRNA: PSPC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSPC1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSPC1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSPC1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PSPC1 (NM_001042414)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSPC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSPC1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSPC1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PSPC1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSPC1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSPC1

    Additional cDNA sequence: 

    AF448795.1 AF449627.1 AK090873.1 AK301554.1 CR457272.1 NR_003272.2 NR_044998.1 

    17 DOTS entries:

    DT.120781485  DT.100824580  DT.100824577  DT.115917  DT.97818050  DT.95162834  DT.97846641  DT.100027436 
    DT.120781442  DT.120785177  DT.92443035  DT.97775653  DT.120781513  DT.92416065  DT.91985431  DT.95157701 
    DT.99993135 

    24/246 AceView cDNA sequences (see all 246):

    AI186575 BQ023153 AA983548 CD366681 BM311507 AA702431 AF448795 CB214993 
    AI912629 CF127194 AA761602 AA600208 CD675694 CB106334 BM678008 AA815372 
    CD367168 BF435523 BM312104 BG746413 BQ687052 BC014184 AI253183 CR457272 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PSPC1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13
    SP1:                                                              -           -                                                   
    SP2:                                                              -     -     -     -     -     -     -     -                     
    SP3:                                                              -     -     -     -     -     -     -     -           -         
    SP4:              -                                                                                                               
    SP5:                                                                          -                                                   


    ECgene alternative splicing isoforms for PSPC1

    Expression
    for PSPC1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PSPC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATATTAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PSPC1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartLeft VentricleHeart
    KidneyMetanephrosKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PSPC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PSPC1

    SOURCE GeneReport for Unigene cluster: Hs.213198

    UniProtKB/Swiss-Prot: PSPC1_HUMAN, Q8WXF1
    Tissue specificity: Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart

        SABiosciences Custom PCR Arrays for PSPC1
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSPC1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PSPC1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSPC1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSPC1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSPC1

    Orthologs
    for PSPC1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PSPC1 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PSPC11 paraspeckle component 1 82.08(n)
    88.82(a)    		   418955  NM_001030831.1  NP_001026002.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PSPC16
    		 --
    		 84(a)
    		 1 ↔ 1
    		 3(187064022-187095613)
    zebrafish
    (Danio rerio)    		 Actinopterygii pspc11 paraspeckle component 1 68.67(n)
    71.08(a)    		   692285  NM_001045258.1  NP_001038723.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta nonA-l6
    nonA6
    		 no on or off transient A
    		 22(a)
    20(a)
    		 many ↔ many
    many ↔ many
    		 3R(12465927-12468834)
    X(16255566-16265580)
    worm
    (Caenorhabditis elegans)    		 Secernentea psf-11 Protein PSF-1 52.89(n)
    45.15(a)    		   175844  NM_065894.3  NP_498295.3 


    ENSEMBL Gene Tree for PSPC1 (if available)
    TreeFam Gene Tree for PSPC1 (if available) 

    Paralogs
    for PSPC1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PSPC1 gene
    NONO2  SFPQ2  
    2 SIMAP similar genes for PSPC1 using alignment to 1 protein entry:     PSPC1_HUMAN:
    SFPQ    NONO

    PSPC1 for paralogs           About GeneDecksing



    Genomic Variants
    for PSPC1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1967 NCBI SNPs in PSPC1 are shown (see all 1967)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1505100831,2
    		C,--20248402(+) AAATA-/AATAATAG 2 -- ds50010--------
    rs1848094451,2
    		--20248445(+) TAGATA/GTGAGG 2 -- ds50010--------
    rs95796441,2
    		C,F,H,--20248452(+) GAGGAG/ATTTGG 2 -- ds500112Minor allele frequency- A:0.12NA NS EA WA 922
    rs1464939161,2
    		--20248506(+) TCCTCA/GCAAGT 2 -- ds50010--------
    rs1482871511,2
    		--20248547(+) ATCTT-/ACTC  
                AGTAG     		2 -- ds50010--------
    rs352414891,2
    		C,--20248677(+) CTGAC-/TGTT  
                TGTTT     		2 -- ds50010--------
    rs586579711,2
    		C--20248689(+) TTGTTTGTT/-  
                AATGA     		2 -- ds50011Minor allele frequency- -:0.00NA 2
    rs559976981,2
    		C,--20248772(+) TGAAAA/GGCTGG 2 -- ds50010--------
    rs1897300941,2
    		--20248924(+) CATGCA/GGTTAA 2 -- nc-transcript-variant0--------
    rs2018512981,2
    		--20248963(+) TAGAC-/TTTTATC 2 -- nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for PSPC1 (20248896 - 20357142 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PSPC1
         1 CNV: 49182

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PSPC1
    DNA2.0 Custom Variant and Variant Library Synthesis for PSPC1

    Disorders / Diseases
    for PSPC1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PSPC1 for disorders           About MalaCards

    PSPC1 for disorders           About GeneDecksing

    OMIM gene information: 612408    OMIM disorders: --


    Export disorders for PSPC1 gene to outside databases

    Publications
    for PSPC1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PSPC1 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with PSPC1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Paraspeckles: a novel nuclear domain. (PubMed id 11790299)1, 2, 3, 9 Fox A.H....Lamond A.I. (2002)
    2. P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner. (PubMed id 16148043)1, 2, 9 Fox A.H.... Lamond A.I. (2005)
    3. Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation. (PubMed id 22416126)1, 2 Passon D.M.... Bond C.S. (2012)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles. (PubMed id 19217333)1, 9 Clemson C.M....Lawrence J.B. (2009)
    6. Expression and functional significance of mouse paraspeckle protein 1 on spermatogenesis. (PubMed id 15140795)1, 9 Myojin R....Kurihara Y. (2004)
    7. MENepsilon/beta noncoding RNAs are essential for structural integrity of nuclear paraspeckles. (PubMed id 19188602)1, 9 Sasaki Y.T....Hirose T. (2009)
    8. p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor. (PubMed id 12810069)1, 9 Ishitani K....Kato S. (2003)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)

    External Searches for PSPC1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PSPC1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55269 HGNC: 20320 AceView: PSPC1 Ensembl:ENSG00000121390 euGenes: HUgn55269
    ECgene: PSPC1 H-InvDB: PSPC1

    Other Databases showing PSPC1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PSPC1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PSPC1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PSPC1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PSPC1 gene:
    Search GeneIP for patents involving PSPC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for PSPC1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for PSPC1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSPC1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSPC1  
     OriGene Protein Over-expression Lysate for PSPC1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for PSPC1   OriGene 3'-UTR Clone for PSPC1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSPC1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSPC1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PSPC1   OriGene Custom Protein Services for PSPC1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PSPC1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PSPC1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSPC1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSPC1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSPC1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSPC1
     GenScript Custom Purified and Recombinant Proteins Services for PSPC1 GenScript cDNA clones with any tag delivered in your preferred vector for PSPC1
     GenScript Custom Assay Services for PSPC1 GenScript Custom Superior Antibodies Services for PSPC1
     GenScript Custom overexpressing Cell Line Services for PSPC1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PSPC1 promoter
     Search Chromatin IP Primers for PSPC1
     RT2 qPCR Primer Assay in human, mouse, rat PSPC1
     Search GNC Networks for PSPC1
     SABiosciences Custom PCR Arrays for PSPC1
     Search Tocris compounds for PSPC1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PSPC1 antibodies
     PSPC1 lysates
     Search for Antibodies for PSPC1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for PSPC1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     PSPC1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for PSPC1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSPC1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PSPC1
     Browse SwitchGear Promoter luciferase reporter plasmids for PSPC1
     ThermoFisher Antibodies for PSPC1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSPC1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      PSPC1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4