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Aliases for PSORS1C3 Gene

Subcategory (RNA class) for PSORS1C3 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for PSORS1C3 Gene

  • Psoriasis Susceptibility 1 Candidate 3 (Non-Protein Coding) 2 3 5
  • Psoriasis Susceptibility 1 Candidate 3 2
  • Non-Protein Coding RNA 196 2
  • NCRNA00196 3

External Ids for PSORS1C3 Gene

Previous GeneCards Identifiers for PSORS1C3 Gene

  • GC00U991169
  • GC06U900577
  • GC06M031250
  • GC06M031142
  • GC06M031143
  • GC06M031267
  • GC06M031302
  • GC06M031358

Summaries for PSORS1C3 Gene

GeneCards Summary for PSORS1C3 Gene

PSORS1C3 (Psoriasis Susceptibility 1 Candidate 3 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with PSORS1C3 include Psoriasis Susceptibility 1 and Psoriasis.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSORS1C3 Gene

Genomics for PSORS1C3 Gene

Regulatory Elements for PSORS1C3 Gene

Enhancers for PSORS1C3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G031269 1.6 FANTOM5 ENCODE dbSUPER 32.6 -93.6 -93563 4.4 HDGF PKNOX1 ATF1 WRNIP1 ARID4B SIN3A GLI4 ZNF2 YY1 ZNF121 HLA-C PSORS1C3 PPT2 DDX39B LY6G5B TCF19 LSM2 PSORS1C2 ATF6B HCG18
GH06G031185 1.5 Ensembl ENCODE dbSUPER 34.7 -8.7 -8650 2.5 PKNOX1 ATF1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF48 MXD4 NFYC ENSG00000272501 PSORS1C3 POU5F1 PSORS1C2 CCHCR1 PSORS1C1 MICB MICA HCG22 HLA-C
GH06G031196 1.4 ENCODE dbSUPER 33.6 -20.0 -19999 3.1 CREB3L1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21 ZNF610 PSORS1C3 ENSG00000272501 POU5F1 PSORS1C2 PRRT1 HLA-C GNL1 EHMT2 CCHCR1 HCG17
GH06G031207 1.4 Ensembl ENCODE dbSUPER 31.2 -31.6 -31583 3.2 ELF3 FOXA2 ARID4B DMAP1 THRB ZNF48 RARA ZNF766 CREM THAP11 POU5F1 PSORS1C3 HLA-C HCG27 CCHCR1 ENSG00000272501 ENSG00000229836 ENSG00000271581 HLA-B AGER
GH06G031202 1.3 ENCODE dbSUPER 29.4 -26.4 -26425 4.6 HDGF PKNOX1 FOXA2 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 YY1 PSORS1C3 ENSG00000272501 HLA-C PSORS1C2 POU5F1 PSORS1C1 MICB LOC101929072 SKIV2L ENSG00000271821
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSORS1C3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PSORS1C3 gene promoter:

Genomic Location for PSORS1C3 Gene

Chromosome:
6
Start:
31,173,735 bp from pter
End:
31,177,899 bp from pter
Size:
4,165 bases
Orientation:
Minus strand

Genomic View for PSORS1C3 Gene

Genes around PSORS1C3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSORS1C3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSORS1C3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for PSORS1C3 Gene

Post-translational modifications for PSORS1C3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PSORS1C3 Gene

Domains & Families for PSORS1C3 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PSORS1C3 Gene

Function for PSORS1C3 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PSORS1C3 Gene

Localization for PSORS1C3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PSORS1C3 Gene

Pathways & Interactions for PSORS1C3 Gene

SuperPathways for PSORS1C3 Gene

No Data Available

Interacting Proteins for PSORS1C3 Gene

Gene Ontology (GO) - Biological Process for PSORS1C3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PSORS1C3 Gene

Drugs & Compounds for PSORS1C3 Gene

(1) Drugs for PSORS1C3 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Allopurinol Approved Pharma 145
genes like me logo Genes that share compounds with PSORS1C3: view

Transcripts for PSORS1C3 Gene

mRNA/cDNA for PSORS1C3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PSORS1C3 Gene

Psoriasis susceptibility 1 candidate 3 (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSORS1C3 Gene

No ASD Table

Relevant External Links for PSORS1C3 Gene

GeneLoc Exon Structure for
PSORS1C3
ECgene alternative splicing isoforms for
PSORS1C3

Expression for PSORS1C3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSORS1C3 Gene

mRNA differential expression in normal tissues according to GTEx for PSORS1C3 Gene

This gene is overexpressed in Bladder (x7.8) and Pancreas (x6.0).

NURSA nuclear receptor signaling pathways regulating expression of PSORS1C3 Gene:

PSORS1C3

SOURCE GeneReport for Unigene cluster for PSORS1C3 Gene:

Hs.670091
genes like me logo Genes that share expression patterns with PSORS1C3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSORS1C3 Gene

Orthologs for PSORS1C3 Gene

Evolution for PSORS1C3 Gene

ENSEMBL:
Gene Tree for PSORS1C3 (if available)
TreeFam:
Gene Tree for PSORS1C3 (if available)

No data available for Orthologs for PSORS1C3 Gene

Paralogs for PSORS1C3 Gene

No data available for Paralogs for PSORS1C3 Gene

Variants for PSORS1C3 Gene

Sequence variations from dbSNP and Humsavar for PSORS1C3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000887637 -- 31,178,738(+) TCTAT(A/G)TGTAA upstream-variant-2KB
rs1001394824 -- 31,174,455(+) CTAAA(A/C)TTCCT intron-variant
rs1001811341 -- 31,179,376(+) ATCTA(C/T)CACGC upstream-variant-2KB
rs1002242370 -- 31,177,824(+) GGTAG(C/G)CTGAG nc-transcript-variant
rs1002500826 -- 31,176,335(+) CATTT(A/G)GCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSORS1C3 Gene

Variant ID Type Subtype PubMed ID
dgv1174e214 CNV gain 21293372
dgv1175e214 CNV gain 21293372
esv2731791 CNV deletion 23290073
esv2759414 CNV gain+loss 17122850
esv32635 CNV gain+loss 17666407
esv3411275 CNV duplication 20981092
esv3608531 CNV loss 21293372
esv3608532 CNV gain 21293372
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv428140 CNV gain+loss 18775914
nsv525933 CNV loss 19592680
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781

Relevant External Links for PSORS1C3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSORS1C3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PSORS1C3 Gene

Disorders for PSORS1C3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PSORS1C3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
psoriasis susceptibility 1
  • psoriasis
psoriasis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PSORS1C3

Genetic Association Database (GAD)
PSORS1C3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSORS1C3
genes like me logo Genes that share disorders with PSORS1C3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSORS1C3 Gene

Publications for PSORS1C3 Gene

  1. Long noncoding RNA expression profile in fibroblast-like synoviocytes from patients with rheumatoid arthritis. (PMID: 27716329) Zhang Y. … Li X.J. (Arthritis Res. Ther. 2016) 2 3 64
  2. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. (PMID: 21051598) . … Zhao M. (Science 2010) 3 46 64
  3. Psoriasis vulgaris in Chinese individuals is associated with PSORS1C3 and CDSN genes. (PMID: 16965413) Chang Y.T. … Tsai S.F. (Br. J. Dermatol. 2006) 3 46 64
  4. HLA-Cw*0602 associates more strongly to psoriasis in the Swedish population than variants of the novel 6p21.3 gene PSORS1C3. (PMID: 15848982) Holm S.J. … O'Brien K.P. (Acta Derm. Venereol. 2005) 3 46 64
  5. A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. (PMID: 21912425) Tohkin M. … Ikezawa Z. (Pharmacogenomics J. 2013) 3 64

Products for PSORS1C3 Gene

Sources for PSORS1C3 Gene

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