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Aliases for PSORS1C1 Gene

Aliases for PSORS1C1 Gene

  • Psoriasis Susceptibility 1 Candidate 1 2 3
  • C6orf16 3 4
  • SEEK1 3 4
  • Psoriasis Susceptibility 1 Candidate Gene 1 Protein 3
  • Chromosome 6 Open Reading Frame 16 2
  • Protein SEEK1 4

External Ids for PSORS1C1 Gene

Previous Symbols for PSORS1C1 Gene

  • C6orf16

Summaries for PSORS1C1 Gene

Entrez Gene Summary for PSORS1C1 Gene

  • This gene is one of several genes thought to confer susceptibility to psoriasis and systemic sclerosis, located on chromosome 6 near the major histocompatibility complex (MHC) class I region. [provided by RefSeq, Sep 2011]

GeneCards Summary for PSORS1C1 Gene

PSORS1C1 (Psoriasis Susceptibility 1 Candidate 1) is a Protein Coding gene. Diseases associated with PSORS1C1 include psoriasis and psoriasis susceptibility 1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSORS1C1 Gene

Genomics for PSORS1C1 Gene

Genomic Location for PSORS1C1 Gene

Start:
31,114,750 bp from pter
End:
31,140,092 bp from pter
Size:
25,343 bases
Orientation:
Plus strand

Genomic View for PSORS1C1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSORS1C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for PSORS1C1 Gene

Proteins for PSORS1C1 Gene

  • Protein details for PSORS1C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIG5-PS1C1_HUMAN
    Recommended name:
    Psoriasis susceptibility 1 candidate gene 1 protein
    Protein Accession:
    Q9UIG5
    Secondary Accessions:
    • B0V083
    • Q5ST21
    • Q86WJ8
    • Q86WJ9
    • Q96QC3

    Protein attributes for PSORS1C1 Gene

    Size:
    152 amino acids
    Molecular mass:
    16580 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB63314.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC54950.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PSORS1C1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSORS1C1 Gene

Proteomics data for PSORS1C1 Gene at MOPED

Post-translational modifications for PSORS1C1 Gene

No Post-translational modifications

Other Protein References for PSORS1C1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PSORS1C1 Gene

Domains for PSORS1C1 Gene

Protein Domains for PSORS1C1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PSORS1C1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PSORS1C1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PSORS1C1 Gene

Function for PSORS1C1 Gene

miRNA for PSORS1C1 Gene

miRTarBase miRNAs that target PSORS1C1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PSORS1C1 Gene

Localization for PSORS1C1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSORS1C1 Gene COMPARTMENTS Subcellular localization image for PSORS1C1 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PSORS1C1 Gene

Pathways for PSORS1C1 Gene

SuperPathways for PSORS1C1 Gene

No Data Available

Interacting Proteins for PSORS1C1 Gene

Gene Ontology (GO) - Biological Process for PSORS1C1 Gene

None

No data available for Pathways by source for PSORS1C1 Gene

Transcripts for PSORS1C1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PSORS1C1 Gene

No ASD Table

Relevant External Links for PSORS1C1 Gene

GeneLoc Exon Structure for
PSORS1C1
ECgene alternative splicing isoforms for
PSORS1C1

Expression for PSORS1C1 Gene

mRNA expression in normal human tissues for PSORS1C1 Gene

mRNA differential expression in normal tissues according to GTEx for PSORS1C1 Gene

This gene is overexpressed in Testis (26.1).

mRNA Expression by UniProt/SwissProt for PSORS1C1 Gene

Q9UIG5-PS1C1_HUMAN
Tissue specificity: Expressed in skin. Also found in heart, placenta, liver, skeletal muscle and pancreas.
genes like me logo Genes that share expressions with PSORS1C1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for PSORS1C1 Gene

Orthologs for PSORS1C1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PSORS1C1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSORS1C1 35
  • 98.03 (n)
  • 96.05 (a)
PSORS1C1 36
  • 95 (a)
OneToOne
Species with no ortholog for PSORS1C1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSORS1C1 Gene

ENSEMBL:
Gene Tree for PSORS1C1 (if available)
TreeFam:
Gene Tree for PSORS1C1 (if available)

Paralogs for PSORS1C1 Gene

Selected SIMAP similar genes for PSORS1C1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PSORS1C1: view

No data available for Paralogs for PSORS1C1 Gene

Variants for PSORS1C1 Gene

Sequence variations from dbSNP and Humsavar for PSORS1C1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1265044 -- 31,122,541(-) gcatc(A/G)gcctc intron-variant
rs1265101 -- 31,136,284(-) tcaac(C/T)tcccg intron-variant
rs1265102 -- 31,135,004(-) actgt(C/T)tctac intron-variant
rs1265103 -- 31,133,201(-) TTGTG(A/G)GGCAG intron-variant
rs2844633 -- 31,128,412(-) CATTC(A/G)TTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSORS1C1 Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV Deletion 23290073
dgv1918e1 CNV Complex 17122850
dgv1919e1 CNV Complex 17122850
nsv428140 CNV Gain+Loss 18775914
esv690 CNV CNV 17122850
nsv525933 CNV Loss 19592680
nsv884137 CNV Loss 21882294
esv33699 CNV Loss 17666407
nsv524061 CNV Loss 19592680

Relevant External Links for PSORS1C1 Gene

HapMap Linkage Disequilibrium report
PSORS1C1
Human Gene Mutation Database (HGMD)
PSORS1C1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSORS1C1 Gene

Disorders for PSORS1C1 Gene

(1) University of Copenhagen DISEASES for PSORS1C1 Gene

Relevant External Links for PSORS1C1

Genetic Association Database (GAD)
PSORS1C1
Human Genome Epidemiology (HuGE) Navigator
PSORS1C1
genes like me logo Genes that share disorders with PSORS1C1: view

No data available for UniProtKB/Swiss-Prot for PSORS1C1 Gene

Publications for PSORS1C1 Gene

  1. Polymorphisms in the SEEK1 and SPR1 genes on 6p21.3 associate with psoriasis in the Swedish population. (PMID: 12930300) Holm S.J. … O'Brien K.P. (Exp. Dermatol. 2003) 3 4 23
  2. A study of PSORS1C1 gene polymorphisms in Chinese patients with psoriasis. (PMID: 16029332) Chang Y.T. … Tsai S.F. (Br. J. Dermatol. 2005) 3 23 48
  3. Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111kb segment telomeric to the HLA-C gene. (PMID: 10545595) Oka A. … Inoko H. (Hum. Mol. Genet. 1999) 3 4
  4. Association of SEEK1 polymorphisms in Crohn's disease. (PMID: 15301859) Peddle L. … Rahman P. (Hum. Immunol. 2004) 3 48
  5. Association of SEEK1 and psoriatic arthritis in two distinct Canadian populations. (PMID: 15708881) Rahman P. … Gladman D.D. (Ann. Rheum. Dis. 2005) 3 48

Products for PSORS1C1 Gene

Sources for PSORS1C1 Gene

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