PSORS1C1 Gene
protein-coding GIFtS: 40
GCID: GC06P031083
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psoriasis susceptibility 1 candidate 1(Previous name: chromosome 6 open reading frame 16 )
(Previous symbol: C6orf16)
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Aliases
for PSORS1C1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Psoriasis Susceptibility 1 Candidate 11 2 | | C6orf161 2 3 | | SEEK11 2 3 | | Chromosome 6 Open Reading Frame 161 | | Psoriasis Susceptibility 1 Candidate Gene 1 Protein2 | | Protein SEEK13 |
Export aliases for PSORS1C1 gene to outside databasesPrevious GC identifers: GC00U991167 GC06U900361 GC06P031188 GC06P031190 GC06P030885 |
Summaries
for PSORS1C1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PSORS1C1:
This gene is one of several genes thought to confer susceptibility to psoriasis and systemic sclerosis, located onchromosome 6 near the major histocompatibility complex (MHC) class I region. (provided by RefSeq, Sep 2011)
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Genomic Views
for PSORS1C1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PSORS1C1 gene promoter:
Max MyoD MIF-1 ITF-2 TGIF Tal-1beta E47 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for PSORS1C1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSORS1C1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.3PSORS1C1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P031083: view genomic region
(about GC identifiers)
Start:
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31,082,527 bp from pter |
End:
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31,107,869 bp from pter |
Size:
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25,343 bases |
Orientation:
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plus strand |
5 alternative locations:
| Chr6+,ALT_REF_LOCI_4 31,050,624-31,075,896 | Chr6+,ALT_REF_LOCI_2 31,075,027-31,139,575 | Chr6+,ALT_REF_LOCI_5 31,075,956-31,101,237 | | Chr6+,ALT_REF_LOCI_3 31,076,302-31,112,648 | Chr6+,ALT_REF_LOCI_6 31,074,948-31,135,897 |
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Proteins
for PSORS1C1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PS1C1_HUMAN, Q9UIG5 (See
protein sequence)Recommended Name: Psoriasis susceptibility 1 candidate gene 1 protein Size: 152 amino acids; 16580 Da
Sequence caution: Sequence=BAB63314.1; Type=Erroneous gene model prediction; Sequence=BAC54950.1; Type=Erroneous genemodel prediction;
Secondary accessions: B0V083 Q5ST21 Q86WJ8 Q86WJ9 Q96QC3Alternative splicing: 2 isoforms: Q9UIG5-1 Q9UIG5-2 Explore the universe of human proteins at neXtProt for PSORS1C1: NX_Q9UIG5
PSORS1C1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_054787.2
ENSEMBL proteins: ENSP00000259881 ENSP00000449471 ENSP00000447158
Human Recombinant Protein Products:
PSORS1C1 Antibody Products:
Assay Products for PSORS1C1: |
Protein
Domains /
Families
for PSORS1C1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9UIG5 |
Function
for PSORS1C1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSORS1C1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSORS1C1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PSORS1C1 (NM_014068) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PSORS1C1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSORS1C1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSORS1C1 |
|
Pathways & Interactions
for PSORS1C1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PSORS1C1
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Drugs & Compounds
for PSORS1C1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PSORS1C1 for compounds About GeneDecksing
 Browse Tocris compounds for PSORS1C1
1 PharmGKB related drug/compound annotation for PSORS1C1 geneAbout this table
Search CenterWatch for drugs/clinical trials and news about PSORS1C1 / PS1C1
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Transcripts
for PSORS1C1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for PSORS1C1 gene: NM_014068.2 9 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000467107 ENST00000548049 ENST00000493289 ENST00000479581 ENST00000259881(uc003nsl.2 uc010jsj.2 uc003nsn.2)
ENST00000550838 ENST00000552747 ENST00000547221 ENST00000481450
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSORS1C1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSORS1C1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PSORS1C1 (NM_014068) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PSORS1C1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSORS1C1 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSORS1C1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PSORS1C1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSORS1C1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSORS1C1 |
19 AceView cDNA sequences: BX640954 BI825917 AF484419 AI874399 AB031479 NM_014068 AF484418 AI343394 BM808976 BI009541 AA045454 AA045072 BE140467 AI243345 AI765106 BE140469 BF817757 BE042193 BG899994
GeneLoc Exon Structure
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Expression
for PSORS1C1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PSORS1C1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See PSORS1C1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PSORS1C1
UniProtKB/Swiss-Prot: PS1C1_HUMAN, Q9UIG5Tissue specificity: Expressed in skin. Also found in heart, placenta, liver, skeletal muscle and pancreas
SABiosciences Custom PCR Arrays for PSORS1C1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSORS1C1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PSORS1C1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSORS1C1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSORS1C1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSORS1C1 |
Orthologs
for PSORS1C1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for PSORS1C1 (if available)
TreeFam Gene Tree for PSORS1C1 (if available) |
Paralogs
for PSORS1C1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for PSORS1C1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PSORS1C1 (31082527 - 31107869 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PSORS1C1
2 CNVs: 7559 3601
Human Gene Mutation Database (HGMD): PSORS1C1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PSORS1C1 |
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Disorders
/ Diseases
for PSORS1C1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PSORS1C1 for disorders About GeneDecksing
OMIM gene information: 613525
OMIM disorders: --
9  diseases for PSORS1C1: About MalaCardspsoriasis psoriasis susceptibility 1 systemic lupus erythematosus lupus erythematosus
psoriatic arthritis kawasaki disease crohn's disease arthritis
toxic epidermal necrolysis
1 disease from the University of Copenhagen DISEASES database for PSORS1C1:Stevens-Johnson syndrome Genetic Association Database (GAD): PSORS1C1
Human Genome Epidemiology (HuGE) Navigator: PSORS1C1 (8 documents)
Export disorders for PSORS1C1 gene to outside databases
|
Publications
for PSORS1C1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PSORS1C1 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with PSORS1C1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A study of PSORS1C1 gene polymorphisms in Chinese patients with psoriasis. (PubMed id 16029332)1, 4, 9 Chang Y.T....Tsai S.F. (2005)
- Polymorphisms in the SEEK1 and SPR1 genes on 6p21.3 associate with psoriasis in the Swedish population. (PubMed id 12930300)1, 2, 9 Holm S.J....O'Brien K.P. (2003)
- Association of SEEK1 and psoriatic arthritis in two distinct Canadian populations. (PubMed id 15708881)1, 4 Rahman P....Gladman D.D. (2005)
- Association of SEEK1 polymorphisms in Crohn's disease. (PubMed id 15301859)1, 4 Peddle L....Rahman P. (2004)
- Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene. (PubMed id 10545595)1, 2 Oka A....Inoko H. (1999)
- A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. (PubMed id 21912425)1 Tohkin M....Ikezawa Z. (2013)
- Genome-wide association study of Stevens-Johnson Synd rome and Toxic Epidermal Necrolysis in Europe. (PubMed id 21801394)1 GAcnin E....Mockenhaupt M. (2011)
- Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis. (PubMed id 21750679)1 Allanore Y....Martinez M. (2011)
- Genome-wide association study of hematological and bi ochemical traits in a Japanese population. (PubMed id 20139978)1 Kamatani Y....Kamatani N. (2010)
- High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (2009)
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External Searches for PSORS1C1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing PSORS1C1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing PSORS1C1 gene
(According to HUGE)
About This Section
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Specialized Databases showing PSORS1C1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PSORS1C1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for PSORS1C1 gene:
Search GeneIP for patents involving PSORS1C1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PSORS1C1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PSORS1C1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSORS1C1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSORS1C1 | | | OriGene Protein Over-expression Lysate for PSORS1C1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PSORS1C1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSORS1C1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSORS1C1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PSORS1C1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PSORS1C1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PSORS1C1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSORS1C1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSORS1C1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSORS1C1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSORS1C1 |
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 | | | PSORS1C1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSORS1C1 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSORS1C1 |
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