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Aliases for PSMG2 Gene

Aliases for PSMG2 Gene

  • Proteasome (Prosome, Macropain) Assembly Chaperone 2 2 3
  • TNFSF5IP1 3 4 6
  • HCCA3 3 4 6
  • Pac2 3 4 6
  • Tumor Necrosis Factor Superfamily, Member 5-Induced Protein 1 2 3
  • Tumor Necrosis Factor Superfamily Member 5-Induced Protein 1 3 4
  • Hepatocellular Carcinoma-Susceptibility Protein 3 3 4
  • Hepatocellular Carcinoma Susceptibility Protein 2 3
  • CD40 Ligand-Activated Specific Transcript 3 2 3
  • CLAST3 3 6
  • PAC-2 3 4
  • Likely Ortholog Of Mouse CD40 Ligand-Activated Specific Transcript 3 (Clast3) 3
  • Proteasome Assembling Chaperone 2 3
  • Proteasome Assembly Chaperone 2 3
  • X 003 Protein 3
  • HDCMC29P 3
  • HSPC260 3
  • HsT1707 3
  • MDS003 3

External Ids for PSMG2 Gene

Previous Symbols for PSMG2 Gene

  • TNFSF5IP1

Summaries for PSMG2 Gene

GeneCards Summary for PSMG2 Gene

PSMG2 (Proteasome (Prosome, Macropain) Assembly Chaperone 2) is a Protein Coding gene. Diseases associated with PSMG2 include hepatocellular carcinoma.

UniProtKB/Swiss-Prot for PSMG2 Gene

  • Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMG2 Gene

Genomics for PSMG2 Gene

Genomic Location for PSMG2 Gene

Start:
12,658,043 bp from pter
End:
12,725,740 bp from pter
Size:
67,698 bases
Orientation:
Plus strand

Genomic View for PSMG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSMG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMG2 Gene

Regulatory Elements for PSMG2 Gene

Proteins for PSMG2 Gene

  • Protein details for PSMG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969U7-PSMG2_HUMAN
    Recommended name:
    Proteasome assembly chaperone 2
    Protein Accession:
    Q969U7
    Secondary Accessions:
    • B0YJB3
    • Q6IAH4
    • Q9NRV1
    • V9GYH7

    Protein attributes for PSMG2 Gene

    Size:
    264 amino acids
    Molecular mass:
    29396 Da
    Quaternary structure:
    • Forms a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.
    SequenceCaution:
    • Sequence=AAF87314.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PSMG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMG2 Gene

Proteomics data for PSMG2 Gene at MOPED

Post-translational modifications for PSMG2 Gene

  • Degraded by the proteasome upon completion of 20S proteasome maturation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys149, Lys156, Lys165, Lys188, and Lys246

Other Protein References for PSMG2 Gene

No data available for DME Specific Peptides for PSMG2 Gene

Domains for PSMG2 Gene

Protein Domains for PSMG2 Gene

Suggested Antigen Peptide Sequences for PSMG2 Gene

Graphical View of Domain Structure for InterPro Entry

Q969U7

UniProtKB/Swiss-Prot:

PSMG2_HUMAN
Family:
  • Belongs to the PSMG2 family.:
    • Q969U7
genes like me logo Genes that share domains with PSMG2: view

No data available for Gene Families for PSMG2 Gene

Function for PSMG2 Gene

Molecular function for PSMG2 Gene

UniProtKB/Swiss-Prot Function: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.

Gene Ontology (GO) - Molecular Function for PSMG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16251969
genes like me logo Genes that share ontologies with PSMG2: view

miRNA for PSMG2 Gene

miRTarBase miRNAs that target PSMG2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PSMG2 Gene

Localization for PSMG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMG2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMG2 Gene COMPARTMENTS Subcellular localization image for PSMG2 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PSMG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with PSMG2: view

Pathways for PSMG2 Gene

SuperPathways for PSMG2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PSMG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007094 mitotic spindle assembly checkpoint IEA --
GO:0043066 negative regulation of apoptotic process IEA --
GO:0043248 proteasome assembly IDA 16251969
GO:0051726 regulation of cell cycle --
genes like me logo Genes that share ontologies with PSMG2: view

No data available for Pathways by source for PSMG2 Gene

Transcripts for PSMG2 Gene

Unigene Clusters for PSMG2 Gene

Proteasome (prosome, macropain) assembly chaperone 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMG2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: - - - -
SP2: -
SP3: - - -
SP4: - - -
SP5:

Relevant External Links for PSMG2 Gene

GeneLoc Exon Structure for
PSMG2
ECgene alternative splicing isoforms for
PSMG2

Expression for PSMG2 Gene

mRNA expression in normal human tissues for PSMG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMG2 Gene

SOURCE GeneReport for Unigene cluster for PSMG2 Gene Hs.464652

mRNA Expression by UniProt/SwissProt for PSMG2 Gene

Q969U7-PSMG2_HUMAN
Tissue specificity: Widely expressed with highest levels in lung, brain and colon. Moderately expressed in muscle, stomach, spleen and heart. Weakly expressed in small intestine, pancreas and liver. Highly expressed in hepatocellular carcinomas with low levels in surrounding liver tissue.
genes like me logo Genes that share expressions with PSMG2: view

No data available for mRNA differential expression in normal tissues for PSMG2 Gene

Orthologs for PSMG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMG2 35
  • 91.42 (n)
  • 89.7 (a)
PSMG2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSMG2 35
  • 87.12 (n)
  • 86.74 (a)
PSMG2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMG2 35
  • 90.03 (n)
  • 89.39 (a)
PSMG2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmg2 35
  • 84.22 (n)
  • 87.88 (a)
Psmg2 16
Psmg2 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PSMG2 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Psmg2 35
  • 82.95 (n)
  • 85.61 (a)
chicken
(Gallus gallus)
Aves PSMG2 35
  • 71.72 (n)
  • 71.21 (a)
PSMG2 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMG2 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia clast3-pending-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia psmg2 35
  • 64.11 (n)
  • 59 (a)
Str.1830 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2938 35
zebrafish
(Danio rerio)
Actinopterygii psmg2 35
  • 60.38 (n)
  • 54.23 (a)
psmg2 36
  • 54 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003826 35
  • 44.06 (n)
  • 34.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12321 35
  • 39.23 (n)
  • 27.57 (a)
CG12321 36
  • 26 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G18940 35
  • 43.98 (n)
  • 32.77 (a)
rice
(Oryza sativa)
Liliopsida Os03g0766900 35
  • 47.29 (n)
  • 31.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.916 36
  • 41 (a)
OneToOne
Species with no ortholog for PSMG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PSMG2 Gene

ENSEMBL:
Gene Tree for PSMG2 (if available)
TreeFam:
Gene Tree for PSMG2 (if available)

Paralogs for PSMG2 Gene

No data available for Paralogs for PSMG2 Gene

Variants for PSMG2 Gene

Sequence variations from dbSNP and Humsavar for PSMG2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs948317 -- 12,717,151(+) actat(A/T)ttgcc intron-variant
rs948318 -- 12,717,186(+) tcaag(C/T)agtct intron-variant
rs948319 -- 12,717,273(+) CTGCT(A/G)CACTA intron-variant
rs963920 -- 12,711,053(+) CGAGA(G/T)CACAC intron-variant
rs1362709 -- 12,722,968(-) CTGAT(A/G)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMG2 Gene

Variant ID Type Subtype PubMed ID
nsv523743 CNV Loss 19592680
esv2716814 CNV Deletion 23290073
esv33130 CNV Loss 17666407

Relevant External Links for PSMG2 Gene

HapMap Linkage Disequilibrium report
PSMG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMG2 Gene

Disorders for PSMG2 Gene

(1) MalaCards Diseases for PSMG2 Gene

Search for PSMG2 Gene in MalaCards »

Relevant External Links for PSMG2

Genetic Association Database (GAD)
PSMG2
Human Genome Epidemiology (HuGE) Navigator
PSMG2
genes like me logo Genes that share disorders with PSMG2: view

No data available for UniProtKB/Swiss-Prot for PSMG2 Gene

Publications for PSMG2 Gene

  1. Expression of liver cancer associated gene HCCA3. (PMID: 11854909) Wang Z.-X. … Wu M.-C. (World J. Gastroenterol. 2001) 2 3 4 23
  2. A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes. (PMID: 16251969) Hirano Y. … Murata S. (Nature 2005) 3 4 23
  3. Growth retardation, polyploidy, and multinucleation induced by Clast3, a novel cell cycle-regulated protein. (PMID: 12147697) Bahar R. … Tagawa M. (J. Biol. Chem. 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes. (PMID: 17189198) Hirano Y. … Murata S. (Mol. Cell 2006) 2 3

Products for PSMG2 Gene

Sources for PSMG2 Gene

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