PSMG2 Gene
protein-coding GIFtS: 50
GCID: GC18P012684
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proteasome (prosome, macropain) assembly chaperone 2(Previous names: tumor necrosis factor superfamily, member 5-induced protein...)
(Previous symbol: TNFSF5IP1)
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Aliases
for PSMG2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Proteasome (Prosome, Macropain) Assembly Chaperone 21 2 | | PAC-22 3 | | HCCA31 2 3 5 | | MGC150921 | | PAC21 2 3 5 | | HDCMC29P2 | | TNFSF5IP11 2 3 5 | | HSPC2602 | | CLAST31 2 5 | | CD40 Ligand-Activated Specific Transcript 32 | | HsT17071 2 | | Hepatocellular Carcinoma Susceptibility Protein2 | | MDS0031 2 | | Likely Ortholog Of Mouse CD40 Ligand-Activated Specific Transcript 3 (Clast3)2 | | Tumor Necrosis Factor Superfamily, Member 5-Induced Protein 11 2 | | Proteasome Assembling Chaperone 22 | | Hepatocellular Carcinoma-Susceptibility Protein 32 3 | | Proteasome Assembly Chaperone 22 | | Tumor Necrosis Factor Superfamily Member 5-Induced Protein 12 3 | | X 003 Protein2 |
Export aliases for PSMG2 gene to outside databases |
Summaries
for PSMG2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PSMG2_HUMAN, Q969U7Function: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. ThePSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alphasubunits into the heteroheptameric alpha ring and prevents alpha ring dimerization
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Genomic Views
for PSMG2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010859.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PSMG2 gene promoter:
TBP HOXA3 Tal-1 YY1 E47 POU2F1 POU2F1b POU2F1a Chx10 POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for PSMG2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSMG2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18p11.21 Ensembl cytogenetic band: 18p11.21 HGNC cytogenetic band: 18p11.21PSMG2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P012684: view genomic region
(about GC identifiers)
Start:
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12,702,425 bp from pter |
End:
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12,725,739 bp from pter |
Size:
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23,315 bases |
Orientation:
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plus strand |
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Proteins
for PSMG2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PSMG2_HUMAN, Q969U7 (See
protein sequence)Recommended Name: Proteasome assembly chaperone 2 Size: 264 amino acids; 29396 Da
Subunit: Forms a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7proteasome alpha subunits
Subcellular location: Nucleus (By similarity)
Secondary accessions: B0YJB3 Q6IAH4Explore the universe of human proteins at neXtProt for PSMG2: NX_Q969U7
Post-translational modifications:
Degraded by the proteasome upon completion of 20S proteasome maturation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q969U7
PSMG2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_064617.2 NP_671692.1
ENSEMBL proteins: ENSP00000325919 ENSP00000467060 ENSP00000468103
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
ISS | -- |
PSMG2 for ontologies About GeneDecksing
PSMG2 Antibody Products:
Assay Products for PSMG2: |
Protein
Domains /
Families
for PSMG2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PSMG2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q969U7ProtoNet protein and cluster: Q969U7 UniProtKB/Swiss-Prot: PSMG2_HUMAN, Q969U7Similarity: Belongs to the PSMG2 family |
Function
for PSMG2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PSMG2_HUMAN, Q969U7Function: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. ThePSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alphasubunits into the heteroheptameric alpha ring and prevents alpha ring dimerization
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSMG2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSMG2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for PSMG2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMG2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMG2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
PSMG2 for ontologies About GeneDecksing
|
Pathways & Interactions
for PSMG2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PSMG2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)
5/25 Interacting proteins for PSMG2 (Q969U72, 3 ENSP000003259194) via UniProtKB, MINT, STRING, and/or I2D (see all 25)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
PSMG2 for ontologies About GeneDecksing
|
Drugs & Compounds
for PSMG2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PSMG2
Search CenterWatch for drugs/clinical trials and news about PSMG2
|
Transcripts
for PSMG2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PSMG2 gene (2 alternative transcripts): NM_020232.4 NM_147163.1 Unigene Cluster for PSMG2: Proteasome (prosome, macropain) assembly chaperone 2 Hs.464652 [show with all ESTs]Unigene Representative Sequence: AK2258824 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000317615(uc002krg.3 uc002krj.2 uc002krk.3) ENST00000590217
ENST00000586587 ENST00000588824
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSMG2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSMG2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): PSMG2 (NM_020232) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PSMG2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMG2 |
Additional cDNA sequence: AF068295.1 AF161378.1 AF168712.1 AK025410.1 AK057005.1 AK225882.1 BC013356.2 CR457181.1 7 DOTS entries: DT.87018200 DT.91789348 DT.87077321 DT.91738447 DT.413953 DT.121092482 DT.121092403 24/189 AceView cDNA sequences (see all 189): NM_020232 BM913325 CB159758 AI804306 CR617853 AW135294 AA416946 AI287674 AL526052 BX282401 BQ231201 BQ937597 BC013356 CR592839 AA653237 AW271624 T36256 CR604508 BU160209 BU689999 CR596477 AA385734 CB128907 AI816968
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for PSMG2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|
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| SP1: | | | - | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PSMG2
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Expression
for PSMG2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PSMG2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTTCATCA
About this image
See PSMG2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PSMG2
SOURCE GeneReport for Unigene cluster: Hs.464652
UniProtKB/Swiss-Prot: PSMG2_HUMAN, Q969U7Tissue specificity: Widely expressed with highest levels in lung, brain and colon. Moderately expressed in muscle,stomach, spleen and heart. Weakly expressed in small intestine, pancreas and liver. Highly expressed in hepatocellularcarcinomas with low levels in surrounding liver tissue
SABiosciences Expression via Pathway-Focused PCR Array including PSMG2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSMG2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PSMG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSMG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSMG2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMG2 |
Orthologs
for PSMG2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PSMG2 gene from 8/26 species (see all 26) About this table
ENSEMBL Gene Tree for PSMG2 (if available)
TreeFam Gene Tree for PSMG2 (if available) |
Paralogs
for PSMG2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for PSMG2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PSMG2 (12702425 - 12725739 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PSMG2
1 CNV: 7178 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PSMG2 |
|
Disorders
/ Diseases
for PSMG2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PSMG2 for disorders About GeneDecksing
OMIM gene information: 609702
OMIM disorders: --
5  diseases for PSMG2: About MalaCardshepatocellular carcinoma carcinoma systemic lupus erythematosus lupus erythematosus
liver cancer
Human Genome Epidemiology (HuGE) Navigator: PSMG2 (1 document)
Export disorders for PSMG2 gene to outside databases
|
Publications
for PSMG2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PSMG2 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with PSMG2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Expression of liver cancer associated gene HCCA3. (PubMed id 11854909)1, 2, 3, 9 Wang Z.X....Wu M.C. (2001)
- A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes. (PubMed id 16251969)1, 2, 9 Hirano Y.... Murata S. (2005)
- Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes. (PubMed id 17189198)1, 3 Hirano Y....Murata S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Growth retardation, polyploidy, and multinucleation induced by Clast3, a novel cell cycle-regulated protein. (PubMed id 12147697)1, 3 Bahar R....Tagawa M. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for PSMG2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PSMG2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PSMG2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PSMG2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PSMG2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PSMG2 gene:
Search GeneIP for patents involving PSMG2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PSMG2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PSMG2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PSMG2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSMG2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSMG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSMG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSMG2 |
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| |  |  |  |  | | | | | | Recombinant Protein for PSMG2 |
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 | | | PSMG2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMG2 |
|  |  |  | | | | ThermoFisher Antibodies for PSMG2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMG2 |
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