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Aliases for PSMG2 Gene

Aliases for PSMG2 Gene

  • Proteasome Assembly Chaperone 2 2 3 5
  • Tumor Necrosis Factor Superfamily Member 5-Induced Protein 1 3 4
  • Proteasome (Prosome, Macropain) Assembly Chaperone 2 2 3
  • Hepatocellular Carcinoma-Susceptibility Protein 3 3 4
  • Hepatocellular Carcinoma Susceptibility Protein 2 3
  • CD40 Ligand-Activated Specific Transcript 3 2 3
  • TNFSF5IP1 3 4
  • HCCA3 3 4
  • PAC-2 3 4
  • PAC2 3 4
  • Likely Ortholog Of Mouse CD40 Ligand-Activated Specific Transcript 3 (Clast3) 3
  • Tumor Necrosis Factor Superfamily, Member 5-Induced Protein 1 2
  • Proteasome Assembling Chaperone 2 3
  • X 003 Protein 3
  • HDCMC29P 3
  • HSPC260 3
  • HsT1707 3
  • CLAST3 3
  • MDS003 3

External Ids for PSMG2 Gene

Previous HGNC Symbols for PSMG2 Gene

  • TNFSF5IP1

Summaries for PSMG2 Gene

GeneCards Summary for PSMG2 Gene

PSMG2 (Proteasome Assembly Chaperone 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PSMG2 Gene

  • Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.

Additional gene information for PSMG2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMG2 Gene

Genomics for PSMG2 Gene

Regulatory Elements for PSMG2 Gene

Enhancers for PSMG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H012989 1.2 ENCODE 57.5 +333.1 333112 3 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 YY1 CEP192 PSMG2 PTPN2 PRELID3A ENSG00000266969 CEP76 ENSG00000267249 ENSG00000267199 ENSG00000260302 RNMT
GH18H012878 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.6 +224.7 224658 8 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF766 PSMG2 CEP192 LINC01882 PTPN2 CEP76 ENSG00000260302 ENSG00000267199 ENSG00000267480 GC18P012884 GC18M015112
GH18H012605 1.8 FANTOM5 Ensembl ENCODE dbSUPER 23.2 -50.6 -50638 3 ELF3 TBP PKNOX1 FOXA2 ZSCAN4 RAD21 RFX5 ZNF366 FOS ATF7 SPIRE1 PSMG2 PRELID3A ENSG00000267199 CEP192 RNU7-129P ENSG00000266969 AFG3L2 CEP76 PTPN2
GH18H012403 1.2 Ensembl ENCODE 20.6 -254.0 -254036 1 HDAC1 ATF1 ARNT NFRKB KLF17 ZBTB40 BATF RFX5 GTF3C2 GATA2 CEP192 PSMG2 PTPN2 PRELID3A MPPE1 RNU7-129P
GH18H012700 1.1 ENCODE 21 +44.5 44466 4 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143 CEP192 SPIRE1 PSMG2 PTPN2 MPPE1 CEP76 PIR52927
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSMG2 on UCSC Golden Path with GeneCards custom track

Promoters for PSMG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000100998 -443 2801 ATF1 ARID4B ZNF121 GLIS2 KLF7 ATF7 SP3 SP5 YY2 SMARCB1

Genomic Location for PSMG2 Gene

Chromosome:
18
Start:
12,658,043 bp from pter
End:
12,725,740 bp from pter
Size:
67,698 bases
Orientation:
Plus strand

Genomic View for PSMG2 Gene

Genes around PSMG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMG2 Gene

Proteins for PSMG2 Gene

  • Protein details for PSMG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969U7-PSMG2_HUMAN
    Recommended name:
    Proteasome assembly chaperone 2
    Protein Accession:
    Q969U7
    Secondary Accessions:
    • B0YJB3
    • Q6IAH4
    • Q9NRV1
    • V9GYH7

    Protein attributes for PSMG2 Gene

    Size:
    264 amino acids
    Molecular mass:
    29396 Da
    Quaternary structure:
    • Forms a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.
    SequenceCaution:
    • Sequence=AAF87314.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PSMG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMG2 Gene

Post-translational modifications for PSMG2 Gene

  • Degraded by the proteasome upon completion of 20S proteasome maturation.
  • Ubiquitination at isoforms=2149, isoforms=2156, Lys165, Lys188, and isoforms=2246
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMG2 Gene

No data available for DME Specific Peptides for PSMG2 Gene

Domains & Families for PSMG2 Gene

Gene Families for PSMG2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PSMG2 Gene

Suggested Antigen Peptide Sequences for PSMG2 Gene

Graphical View of Domain Structure for InterPro Entry

Q969U7

UniProtKB/Swiss-Prot:

PSMG2_HUMAN :
  • Belongs to the PSMG2 family.
Family:
  • Belongs to the PSMG2 family.
genes like me logo Genes that share domains with PSMG2: view

Function for PSMG2 Gene

Molecular function for PSMG2 Gene

UniProtKB/Swiss-Prot Function:
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.

Phenotypes From GWAS Catalog for PSMG2 Gene

Gene Ontology (GO) - Molecular Function for PSMG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16251969
genes like me logo Genes that share ontologies with PSMG2: view

Phenotypes for PSMG2 Gene

genes like me logo Genes that share phenotypes with PSMG2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PSMG2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMG2 Gene

Localization for PSMG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMG2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMG2 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IBA --
GO:0005634 nucleus ISS --
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with PSMG2: view

Pathways & Interactions for PSMG2 Gene

SuperPathways for PSMG2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PSMG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007094 mitotic spindle assembly checkpoint IEA --
GO:0043066 negative regulation of apoptotic process IEA --
GO:0043248 proteasome assembly IDA 16251969
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with PSMG2: view

No data available for Pathways by source and SIGNOR curated interactions for PSMG2 Gene

Drugs & Compounds for PSMG2 Gene

No Compound Related Data Available

Transcripts for PSMG2 Gene

Unigene Clusters for PSMG2 Gene

Proteasome (prosome, macropain) assembly chaperone 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PSMG2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PSMG2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: - - - -
SP2: -
SP3: - - -
SP4: - - -
SP5:

Relevant External Links for PSMG2 Gene

GeneLoc Exon Structure for
PSMG2
ECgene alternative splicing isoforms for
PSMG2

Expression for PSMG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMG2 Gene

This gene is overexpressed in Breast (32.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMG2 Gene



Protein tissue co-expression partners for PSMG2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMG2 Gene:

PSMG2

SOURCE GeneReport for Unigene cluster for PSMG2 Gene:

Hs.464652

mRNA Expression by UniProt/SwissProt for PSMG2 Gene:

Q969U7-PSMG2_HUMAN
Tissue specificity: Widely expressed with highest levels in lung, brain and colon. Moderately expressed in muscle, stomach, spleen and heart. Weakly expressed in small intestine, pancreas and liver. Highly expressed in hepatocellular carcinomas with low levels in surrounding liver tissue.

Evidence on tissue expression from TISSUES for PSMG2 Gene

  • Muscle(4.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with PSMG2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMG2 Gene

Orthologs for PSMG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMG2 33 34
  • 91.42 (n)
dog
(Canis familiaris)
Mammalia PSMG2 33 34
  • 90.03 (n)
cow
(Bos Taurus)
Mammalia PSMG2 33 34
  • 87.12 (n)
mouse
(Mus musculus)
Mammalia Psmg2 33 16 34
  • 84.22 (n)
rat
(Rattus norvegicus)
Mammalia Psmg2 33
  • 82.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 74 (a)
OneToMany
-- 34
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia PSMG2 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMG2 33 34
  • 71.72 (n)
lizard
(Anolis carolinensis)
Reptilia PSMG2 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmg2 33
  • 64.11 (n)
Str.1830 33
African clawed frog
(Xenopus laevis)
Amphibia clast3-pending-prov 33
zebrafish
(Danio rerio)
Actinopterygii psmg2 33 34
  • 60.38 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2938 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003826 33
  • 44.06 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12321 33 34
  • 39.23 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G18940 33
  • 43.98 (n)
rice
(Oryza sativa)
Liliopsida Os03g0766900 33
  • 47.29 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.916 34
  • 41 (a)
OneToOne
Species where no ortholog for PSMG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PSMG2 Gene

ENSEMBL:
Gene Tree for PSMG2 (if available)
TreeFam:
Gene Tree for PSMG2 (if available)

Paralogs for PSMG2 Gene

No data available for Paralogs for PSMG2 Gene

Variants for PSMG2 Gene

Sequence variations from dbSNP and Humsavar for PSMG2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000018450 -- 12,659,565(+) CCCGG(A/G)AGGCT intron-variant, upstream-variant-2KB
rs1000060389 -- 12,717,794(+) CTGGA(C/T)GTGGA intron-variant
rs1000071999 -- 12,700,636(+) AGATC(A/G)TAATG intron-variant, upstream-variant-2KB
rs1000113143 -- 12,663,052(+) AGGCC(A/G)AGCCA intron-variant
rs1000146234 -- 12,720,992(+) TGGCT(A/G)ATATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMG2 Gene

Variant ID Type Subtype PubMed ID
esv2716814 CNV deletion 23290073
esv33130 CNV loss 17666407
esv3430281 CNV insertion 20981092
nsv1063125 CNV loss 25217958
nsv1064273 CNV gain 25217958
nsv1123161 CNV deletion 24896259
nsv523743 CNV loss 19592680
nsv576507 CNV loss 21841781

Variation tolerance for PSMG2 Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMG2 Gene

Disorders for PSMG2 Gene

Relevant External Links for PSMG2

Genetic Association Database (GAD)
PSMG2
Human Genome Epidemiology (HuGE) Navigator
PSMG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMG2

No disorders were found for PSMG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMG2 Gene

Publications for PSMG2 Gene

  1. Expression of liver cancer associated gene HCCA3. (PMID: 11854909) Wang ZX … Wu MC (World journal of gastroenterology 2001) 2 3 4 22 60
  2. A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes. (PMID: 16251969) Hirano Y … Murata S (Nature 2005) 3 4 22 60
  3. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PMID: 18174230) Miyagawa H … Horiuchi T (Rheumatology (Oxford, England) 2008) 3 45 60
  4. Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. (PMID: 18978792) Cooper JD … Todd JA (Nature genetics 2008) 3 45 60
  5. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. (PMID: 17554260) Todd JA … Clayton DG (Nature genetics 2007) 3 45 60

Products for PSMG2 Gene

Sources for PSMG2 Gene

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