Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PSMF1 Gene

Aliases for PSMF1 Gene

  • Proteasome Inhibitor Subunit 1 2 3 5
  • Proteasome (Prosome, Macropain) Inhibitor Subunit 1 (PI31) 2 3
  • Proteasome Inhibitor HP131 Subunit 2
  • HPI31 4
  • PI31 3

External Ids for PSMF1 Gene

Previous GeneCards Identifiers for PSMF1 Gene

  • GC20P001087
  • GC20P001088
  • GC20P001041
  • GC20P001094

Summaries for PSMF1 Gene

Entrez Gene Summary for PSMF1 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMF1 Gene

PSMF1 (Proteasome Inhibitor Subunit 1) is a Protein Coding gene. Among its related pathways are Cell Cycle Checkpoints and Mitotic Metaphase and Anaphase. GO annotations related to this gene include endopeptidase inhibitor activity and proteasome binding.

UniProtKB/Swiss-Prot for PSMF1 Gene

  • Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

Gene Wiki entry for PSMF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMF1 Gene

Genomics for PSMF1 Gene

Regulatory Elements for PSMF1 Gene

Enhancers for PSMF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSMF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSMF1 Gene

1,113,263 bp from pter
1,189,415 bp from pter
76,153 bases
Plus strand

Genomic View for PSMF1 Gene

Genes around PSMF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMF1 Gene

Proteins for PSMF1 Gene

  • Protein details for PSMF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proteasome inhibitor PI31 subunit
    Protein Accession:
    Secondary Accessions:
    • A0AVQ9
    • D3DVW3
    • Q9H4I1

    Protein attributes for PSMF1 Gene

    271 amino acids
    Molecular mass:
    29817 Da
    Quaternary structure:
    • Monomer and homodimer. Interacts with FBXO7. Interacts with the 20S proteasome.

    Three dimensional structures from OCA and Proteopedia for PSMF1 Gene

neXtProt entry for PSMF1 Gene

Proteomics data for PSMF1 Gene at MOPED

Post-translational modifications for PSMF1 Gene

  • Ubiquitination at Lys 125 and Lys 148
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSMF1 Gene

Domains & Families for PSMF1 Gene

Gene Families for PSMF1 Gene

Protein Domains for PSMF1 Gene

Suggested Antigen Peptide Sequences for PSMF1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the proteasome inhibitor PI31 family.
  • Belongs to the proteasome inhibitor PI31 family.
genes like me logo Genes that share domains with PSMF1: view

Function for PSMF1 Gene

Molecular function for PSMF1 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.
genes like me logo Genes that share phenotypes with PSMF1: view

Animal Models for PSMF1 Gene

MGI Knock Outs for PSMF1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMF1 Gene

Localization for PSMF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMF1 Gene

Cytoplasm. Endoplasmic reticulum.

Subcellular locations from

Jensen Localization Image for PSMF1 Gene COMPARTMENTS Subcellular localization image for PSMF1 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
nucleus 5
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PSMF1 Gene

Pathways & Interactions for PSMF1 Gene

SuperPathways for PSMF1 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 Interleukin-3, 5 and GM-CSF signaling
3 Infectious disease
4 Immune System
5 Cell Cycle, Mitotic
genes like me logo Genes that share pathways with PSMF1: view

Gene Ontology (GO) - Biological Process for PSMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with PSMF1: view

No data available for SIGNOR curated interactions for PSMF1 Gene

Drugs & Compounds for PSMF1 Gene

(2) Drugs for PSMF1 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 776
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMF1: view

Transcripts for PSMF1 Gene

Unigene Clusters for PSMF1 Gene

Proteasome (prosome, macropain) inhibitor subunit 1 (PI31):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - -
SP6: - - -

Relevant External Links for PSMF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSMF1 Gene

mRNA expression in normal human tissues for PSMF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMF1 Gene

SOURCE GeneReport for Unigene cluster for PSMF1 Gene Hs.471917

genes like me logo Genes that share expression patterns with PSMF1: view

Protein tissue co-expression partners for PSMF1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMF1 Gene

Orthologs for PSMF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PSMF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PSMF1 35
  • 90.62 (n)
  • 91.48 (a)
PSMF1 36
  • 91 (a)
(Canis familiaris)
Mammalia PSMF1 35
  • 89.91 (n)
  • 90.41 (a)
PSMF1 36
  • 90 (a)
(Mus musculus)
Mammalia Psmf1 35
  • 86.47 (n)
  • 83.76 (a)
Psmf1 16
Psmf1 36
  • 84 (a)
(Pan troglodytes)
Mammalia PSMF1 35
  • 99.38 (n)
  • 98.52 (a)
PSMF1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Psmf1 35
  • 87.08 (n)
  • 86.72 (a)
(Monodelphis domestica)
Mammalia PSMF1 36
  • 77 (a)
(Gallus gallus)
Aves PSMF1 35
  • 64.33 (n)
  • 62.36 (a)
PSMF1 36
  • 62 (a)
(Anolis carolinensis)
Reptilia PSMF1 36
  • 56 (a)
(Danio rerio)
Actinopterygii psmf1 35
  • 56.09 (n)
  • 51.66 (a)
psmf1 36
  • 49 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007418 35
  • 43.97 (n)
  • 33.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta PI31 35
  • 42.47 (n)
  • 33.06 (a)
Species with no ortholog for PSMF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PSMF1 Gene

Gene Tree for PSMF1 (if available)
Gene Tree for PSMF1 (if available)

Paralogs for PSMF1 Gene

No data available for Paralogs for PSMF1 Gene

Variants for PSMF1 Gene

Sequence variations from dbSNP and Humsavar for PSMF1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs2235587 - 1,135,276(-) GGTGG(C/T)GTGGA reference, missense
VAR_024564 -
rs2404 -- 1,166,309(-) GATCT(C/T)GTGCC utr-variant-3-prime
rs14581 -- 1,167,075(+) CATTT(C/T)TTTTG utr-variant-3-prime
rs1049901 -- 1,167,131(+) TAGGT(A/G)TTCTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PSMF1 Gene

Variant ID Type Subtype PubMed ID
nsv912585 CNV Gain 21882294
esv2722050 CNV Deletion 23290073
esv2722052 CNV Deletion 23290073
dgv691e201 CNV Deletion 23290073
dgv692e201 CNV Deletion 23290073
esv2674425 CNV Deletion 23128226
dgv693e201 CNV Deletion 23290073
dgv694e201 CNV Deletion 23290073
esv2722058 CNV Deletion 23290073
nsv179964 CNV Loss 16902084
esv2722059 CNV Deletion 23290073
esv2722060 CNV Deletion 23290073
nsv179100 CNV Loss 16902084
esv2524932 CNV Deletion 19546169
esv2666587 CNV Deletion 23128226
esv1136177 CNV Insertion 17803354
esv270818 CNV Insertion 20981092

Variation tolerance for PSMF1 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.54% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PSMF1 Gene

Disorders for PSMF1 Gene

Relevant External Links for PSMF1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PSMF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMF1 Gene

Publications for PSMF1 Gene

  1. Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor. (PMID: 18495667) Kirk R. … McDonald N.Q. (J. Biol. Chem. 2008) 3 4 67
  2. The proteasome-dependent proteolytic system. (PMID: 10363639) Tanahashi N. … Tanaka K. (Mol. Biol. Rep. 1999) 2 3
  3. The FP domains of PI31 and Fbxo7 have the same protein fold but very different modes of protein-protein interaction. (PMID: 25266262) Shang J. … Du Z. (J. Biomol. Struct. Dyn. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for PSMF1 Gene

Sources for PSMF1 Gene