Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PSMF1 Gene

protein-coding GIFtS: 56
GCID: GC20P001041

proteasome (prosome, macropain) inhibitor subunit 1 (PI31)

Explore 2 diseases affiliated with
PSMF1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Proteasome (Prosome, Macropain) Inhibitor Subunit 1 (PI31)¹ ²
PI31¹ ²
HPI31¹
Proteasome Inhibitor HP131 Subunit²
Proteasome Inhibitor PI31 Subunit²

External Ids:	HGNC: 9571¹	Entrez Gene: 9491²	Ensembl: ENSG00000125818⁷	UniProtKB: Q92530³

Export aliases for PSMF1 gene to outside databases

Previous GC identifers: GC20P001087 GC20P001088

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PSMF1:

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a

20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed

of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which

contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits.

Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an

ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the

immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation

of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PSMF1_HUMAN, Q92530

Function: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide

substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins

PA700 and PA28

Gene Wiki entry for PSMF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011387.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PSMF1 gene promoter:
NRSF form 1 NRSF form 2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PSMF1 promoter sequence

Search SABiosciences Chromatin IP Primers for PSMF1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSMF1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13

PSMF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMF1 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P001041: view genomic region (about GC identifiers)

Start:	1,093,906 bp from pter	End:	1,149,022 bp from pter
Size:	55,117 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PSMF1_HUMAN, Q92530 (See protein sequence)

Recommended Name: Proteasome inhibitor PI31 subunit

Size: 271 amino acids; 29817 Da

Subunit: Monomer (Probable)

1 PDB 3D structure from and Proteopedia for PSMF1:

2VT8 (3D)

Secondary accessions: A0AVQ9 D3DVW3 Q9H4I1

Explore the universe of human proteins at neXtProt for PSMF1: NX_Q92530

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92530

PSMF1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_006805.2 NP_848693.2

ENSEMBL proteins:

ENSP00000371324 ENSP00000246015 ENSP00000338039 ENSP00000396547 ENSP00000401404

ENSP00000327704 ENSP00000371323

Reactome Protein details: Q92530
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): PSMF1 OriGene Protein Over-expression Lysate (see all 2): PSMF1 OriGene Custom Protein Services for PSMF1
	GenScript Custom Purified and Recombinant Proteins Services for PSMF1
	Novus Biologicals PSMF1 Proteins Novus Biologicals PSMF1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for PSMF1
	Uscn Proteins for PSMF1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000502	proteasome complex	--	--
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--
GO:0005839	proteasome core complex	NAS	10764772

PSMF1 for ontologies About GeneDecksing

PSMF1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 4): PSMF1 OriGene Custom Antibody Services for PSMF1
	GenScript Custom Superior Antibodies Services for PSMF1
	Novus Biologicals PSMF1 Antibodies
	Abcam antibodies for PSMF1
	Uscn Antibodies for PSMF1
	ThermoFisher Antibodies for PSMF1

Assay Products for PSMF1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PSMF1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PSMF1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PSMF1 for domains About GeneDecksing

2 InterPro domains/families:

IPR021625 Inhibitor_PI31

IPR013886 PI31_Prot_Reg

Graphical View of Domain Structure for InterPro Entry Q92530

ProtoNet protein and cluster: Q92530

1 Blocks protein family: IPB013886 PI31 proteasome regulator

UniProtKB/Swiss-Prot: PSMF1_HUMAN, Q92530

Similarity: Belongs to the proteasome inhibitor PI31 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PSMF1_HUMAN, Q92530

Function: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide

substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins

PA700 and PA28

miRNA Products:		OriGene 3'-UTR Clone (see all 2): PSMF1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSMF1
		8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate PSMF1 (see all 47):
		hsa-miR-21* hsa-miR-140-5p hsa-miR-218-1* hsa-miR-200a hsa-miR-374a hsa-miR-570 hsa-miR-141 hsa-miR-1304

		SwitchGear 3'UTR luciferase reporter plasmid: PSMF1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSMF1 (see all 7) OriGene shRNA RFP: PSMF1 OriGene siRNA: PSMF1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSMF1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PSMF1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSMF1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSMF1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): PSMF1 (NM_006814)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSMF1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMF1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PSMF1
		Search LifeMap BioReagents cell lines for PSMF1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMF1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004866	endopeptidase inhibitor activity	NAS	10764772
GO:0005515	protein binding	IPI	16713569

PSMF1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for PSMF1:

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/75 pathways (see all 75)
Ubiquitinated Orc1 is degraded by the proteasome	1.00	Assembly of the pre-replicative complex	0.77
Proteasomal cleavage of substrate	0.98	Degradation of ubiquitinated p27/p21 by the 26S proteasome	0.75
Proteasome mediated degradation of PAK-2p34	0.98	SCF(Skp2)-mediated degradation of p27/p21	0.75
Proteasomal cleavage of substrate	0.98	APC/C:Cdh1-mediated degradation of Skp2	0.74

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Antigen processing: Ubiquitination & Proteasome degradation

Antigen processing: Ubiquitination & Proteasome degradation

1.00

Class I MHC mediated antigen processing & presentation

0.83

Immune System

Immune System

1.00

Adaptive Immune System

0.59

HIV Infection

HIV Infection

1.00

Host Interactions of HIV factors

0.64

Pathway sources
See GeneCards unified pathways
Show all pathways

5/98 Reactome Pathways for PSMF1 (see all 98)

	Ubiquitinated geminin is degraded by the proteasome
	Proteolytic degradation of ubiquitinated-Cdc25A
	Orc1 removal from chromatin
	CDK-mediated phosphorylation and removal of Cdc6
	ER-Phagosome pathway

1 Kegg Pathway (Kegg details for PSMF1):

Proteasome

PSMF1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PSMF1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/133 Interacting proteins for PSMF1 (Q92530^{1, 2, 3} ENSP00000327704⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 133)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD2BP2	O95400²^,³, ENSP00000304903⁴	MINT-62651 MINT-62663 I2D: score=2 STRING: ENSP00000304903
RBFOX1	Q9NWB1¹^,³, ENSP00000309117⁴	EBI-945916,EBI-1047634 I2D: score=2 STRING: ENSP00000309117
RHOXF2	Q9BQY4³, ENSP00000360441⁴	I2D: score=4 STRING: ENSP00000360441
BEND7	Q8N7W2³, ENSP00000345773⁴	I2D: score=3 STRING: ENSP00000345773
CCDC85B	Q15834³, ENSP00000311695⁴	I2D: score=3 STRING: ENSP00000311695

About this table

Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000084	S phase of mitotic cell cycle	TAS	--
GO:0000209	protein polyubiquitination	TAS	--
GO:0000216	M/G1 transition of mitotic cell cycle	TAS	--

PSMF1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PSMF1
Search CenterWatch for drugs/clinical trials and news about PSMF1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PSMF1 gene (3 alternative transcripts):

NM_006814.3 NM_178578.2 NM_178579.1

Unigene Cluster for PSMF1:

Proteasome (prosome, macropain) inhibitor subunit 1 (PI31)

Hs.471917 [show with all ESTs]

Unigene Representative Sequence: NM_006814

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000381899 ENST00000479715 ENST00000246015(uc010zpp.2) ENST00000335877(uc002wen.4)

ENST00000478004 ENST00000461847 ENST00000484891(uc002wep.4) ENST00000435720

ENST00000438768 ENST00000333082(uc010zpo.2 uc002wel.4) ENST00000381898

miRNA Products:		OriGene 3'-UTR Clone (see all 2): PSMF1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSMF1
		8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate PSMF1 (see all 47):
		hsa-miR-21* hsa-miR-140-5p hsa-miR-218-1* hsa-miR-200a hsa-miR-374a hsa-miR-570 hsa-miR-141 hsa-miR-1304

		SwitchGear 3'UTR luciferase reporter plasmid: PSMF1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSMF1 (see all 7) OriGene shRNA RFP: PSMF1 OriGene siRNA: PSMF1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSMF1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSMF1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSMF1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): PSMF1 (NM_006814)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSMF1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMF1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSMF1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PSMF1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSMF1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSMF1

Additional cDNA sequence:

AF055032.1 AK294134.1 AK300667.1 AK302164.1 BC029836.1 BC126127.1 BC126462.1 D88378.1

24/28 DOTS entries (see all 28):

DT.455109 DT.91773500 DT.100841453 DT.95268312 DT.120811472 DT.101959133 DT.120811443 DT.100841442

DT.97779331 DT.100841440 DT.100841447 DT.95268867 DT.40132530 DT.95268311 DT.120811527 DT.210795

DT.100841454 DT.120811513 DT.319527 DT.100841451 DT.120811447 DT.120811474 DT.120811502 DT.99983196

24/541 AceView cDNA sequences (see all 541):

BX089168 BM696664 AI050783 AI089637 NM_178579 BF928030 AW473385 BQ024314

BX114789 AA251101 AI095036 AI092877 F09240 R83911 BP375747 AI362215

T35281 AA011302 AI492323 AW381382 AA873845 BI494661 BQ028886 AA370637

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PSMF1 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	·	11c
SP1:													-								-		-		-
SP2:													-				-		-		-		-		-		-				-		-
SP3:													-								-		-		-						-		-
SP4:																					-		-		-
SP5:																							-		-

ECgene alternative splicing isoforms for PSMF1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PSMF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGCCGGTTT

About this image
See PSMF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PSMF1

SOURCE GeneReport for Unigene cluster: Hs.471917

SABiosciences Custom PCR Arrays for PSMF1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSMF1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PSMF1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSMF1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSMF1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMF1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMF1 gene from 7/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Psmf1^{1 , 5}	proteasome (prosome, macropain) inhibitor subunit 1^{1, 5}	86.47(n)¹ 83.76(a)¹		2 (74.83 cM)⁵ 228769¹ NM_212446.1¹ NP_997611.1¹ 151715812⁵
chicken (Gallus gallus)	Aves	PSMF1¹	proteasome (prosome, macropain) inhibitor subunit 1 more	64.33(n) 62.36(a)		430115 NM_001031582.1 NP_001026753.1
lizard (Anolis carolinensis)	Reptilia	PSMF1⁶	--	61(a)	1 ↔ 1	GL343346.1(666020-678145)
zebrafish (Danio rerio)	Actinopterygii	psmf1¹	proteasome (prosome, macropain) inhibitor subunit 1	56.09(n) 51.66(a)		436820 NM_001002547.2 NP_001002547.2
fruit fly (Drosophila melanogaster)	Insecta	CG8979¹	CG8979	42.95(n) 33.33(a)		36277 NM_165854.1 NP_725092.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G53970⁶ AT1G48530⁶	uncharacterized protein	21(a) 17(a)	many → 1 many → 1	3(19985139-19987339) 1(17943242-17944315)
rice (Oryza sativa)	Liliopsida	--	proteasome inhibitor-related, putative, expressed	20(a)	1 ↔ 1	7(21787582-21792869)

ENSEMBL Gene Tree for PSMF1 (if available)
TreeFam Gene Tree for PSMF1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185907190^1,2		--	1091931(+)	`GAGGCA/GGAGGT`	1	--	us2k¹		0	--	--	--	--
rs143669648^1,2		--	1091958(+)	`CGTGCC/TACTGT`	1	--	us2k¹		0	--	--	--	--
rs191057652^1,2		--	1091984(+)	`ATAGAA/GCAACA`	1	--	us2k¹		0	--	--	--	--
rs7267737^1,2	C,F,	--	1092010(+)	`aaaTCA/Gtatat`	1	--	us2k¹		1		NA	120
rs116056251^1,2	F,	--	1092011(+)	`AATCAT/GATATA`	1	--	us2k¹		1		WA	118
rs78982261^1,2		--	1092144(+)	`CCTCAC/TACTTC`	1	--	us2k¹		0	--	--	--	--
rs140917082^1,2		--	1092341(+)	`ATGCTA/GGGGAA`	1	--	us2k¹		0	--	--	--	--
rs13045628^1,2	C,F,H,	--	1092441(+)	`taagaC/Tgtaaa`	1	--	us2k¹		7		EA NS NA	398
rs6077768^1,2	C,F,H,	--	1092456(+)	`TAAAAC/TTCTTG`	1	--	us2k¹		19		NS EA NA WA CSA	2337
rs75991661^1,2		--	1092555(+)	`AATCAG/AGCAAA`	1	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for PSMF1 (1093906 - 1149022 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for PSMF1
1 CNV: 102895
2 Indels: 12138 12139

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PSMF1

DNA2.0 Custom Variant and Variant Library Synthesis for PSMF1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PSMF1 for disorders About GeneDecksing

2 diseases for PSMF1: About MalaCards

ataxia immunodeficiency

Export disorders for PSMF1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PSMF1 gene, integrated from 9 sources (see all 58):
(articles sorted by number of sources associating them with PSMF1)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
cDNA cloning, expression, and functional characterization of PI31, a proline-rich inhibitor of the proteasome. (PubMed id 10764772)^{1, 2} McCutchen-Maloney S.L.... DeMartino G.N. (2000)
The proteasome-dependent proteolytic system. (PubMed id 10363639)^{1, 3} Tanahashi N....Tanaka K. (1999)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)¹ Altun M....Kessler B.M. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9491	HGNC: 9571	AceView: PSMF1	Ensembl:ENSG00000125818	euGenes: HUgn9491
ECgene: PSMF1	Kegg: 9491	H-InvDB: PSMF1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PSMF1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PSMF1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PSMF1 gene:
Search GeneIP for patents involving PSMF1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for PSMF1		OriGene shRNA RFP for PSMF1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSMF1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSMF1
	OriGene Protein Over-expression Lysate for PSMF1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for PSMF1		OriGene 3'-UTR Clone for PSMF1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSMF1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSMF1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for PSMF1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for PSMF1		OriGene Custom Protein Services for PSMF1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PSMF1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PSMF1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSMF1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSMF1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSMF1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSMF1

	GenScript Custom Purified and Recombinant Proteins Services for PSMF1		GenScript cDNA clones with any tag delivered in your preferred vector for PSMF1
	GenScript Custom Assay Services for PSMF1		GenScript Custom Superior Antibodies Services for PSMF1
	GenScript Custom overexpressing Cell Line Services for PSMF1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in PSMF1 promoter
	Search Chromatin IP Primers for PSMF1
	RT² qPCR Primer Assay in human, mouse, rat PSMF1
	Search GNC Networks for PSMF1
	SABiosciences Custom PCR Arrays for PSMF1

Search Tocris compounds for PSMF1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	PSMF1 antibodies
	PSMF1 proteins
	PSMF1 lysates

	Antibodies for PSMF1
	See all of Abcam's Antibodies, Kits and Proteins for PSMF1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for PSMF1

PSMF1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for PSMF1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMF1

	SwitchGear 3'UTR luciferase reporter plasmids for PSMF1
	SwitchGear Promoter luciferase reporter plasmids for PSMF1

ThermoFisher Antibodies for PSMF1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMF1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PSMF1 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

PSMF1 Gene

proteasome (prosome, macropain) inhibitor subunit 1 (PI31)

Aliases
for PSMF1 gene

Summaries
for PSMF1 gene

Genomic Views
for PSMF1 gene

Proteins
for PSMF1 gene

Protein Domains /
Families
for PSMF1 gene

Function
for PSMF1 gene

Pathways & Interactions
for PSMF1 gene

Drugs & Compounds
for PSMF1 gene

Transcripts
for PSMF1 gene

Expression
for PSMF1 gene

Orthologs
for PSMF1 gene

Paralogs
for PSMF1 gene

Genomic Variants
for PSMF1 gene

Disorders / Diseases
for PSMF1 gene

Publications
for PSMF1 gene

External Searches for PSMF1 gene

Genome Databases showing PSMF1 gene

Other Databases showing PSMF1 gene

Specialized Databases showing PSMF1 gene

Intellectual Property
for PSMF1 gene

Products
for PSMF1 gene

View Random Gene

Advanced Search

Export list of displayed genes

PSMF1 Gene

proteasome (prosome, macropain) inhibitor subunit 1 (PI31)

Aliasesfor PSMF1 gene

Summariesfor PSMF1 gene

Genomic Viewsfor PSMF1 gene

Proteinsfor PSMF1 gene

Protein Domains /Familiesfor PSMF1 gene

Functionfor PSMF1 gene

Pathways & Interactionsfor PSMF1 gene

Drugs & Compoundsfor PSMF1 gene

Transcriptsfor PSMF1 gene

Expression for PSMF1 gene

Orthologsfor PSMF1 gene

Paralogsfor PSMF1 gene

Genomic Variantsfor PSMF1 gene

Disorders / Diseasesfor PSMF1 gene

Publicationsfor PSMF1 gene

External Searches for PSMF1 gene

Genome Databases showing PSMF1 gene

Other Databases showing PSMF1 gene

Specialized Databases showing PSMF1 gene

Intellectual Propertyfor PSMF1 gene

Productsfor PSMF1 gene

View Random Gene

Aliases
for PSMF1 gene

Summaries
for PSMF1 gene

Genomic Views
for PSMF1 gene

Proteins
for PSMF1 gene

Protein Domains /
Families
for PSMF1 gene

Function
for PSMF1 gene

Pathways & Interactions
for PSMF1 gene

Drugs & Compounds
for PSMF1 gene

Transcripts
for PSMF1 gene

Expression
for PSMF1 gene

Orthologs
for PSMF1 gene

Paralogs
for PSMF1 gene

Genomic Variants
for PSMF1 gene

Disorders / Diseases
for PSMF1 gene

Publications
for PSMF1 gene

Intellectual Property
for PSMF1 gene

Products
for PSMF1 gene