Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PSME4 Gene

Aliases for PSME4 Gene

  • Proteasome Activator Subunit 4 2 3 5
  • Proteasome (Prosome, Macropain) Activator Subunit 4 2 3
  • Proteasome Activator PA200 3 4
  • Proteasome Activator Complex Subunit 4 3
  • Proteasome Activator 200 KDa 3
  • KIAA0077 4
  • PA200 3

External Ids for PSME4 Gene

Previous GeneCards Identifiers for PSME4 Gene

  • GC02M054048
  • GC02M054066
  • GC02M054003
  • GC02M054091
  • GC02M053825

Summaries for PSME4 Gene

GeneCards Summary for PSME4 Gene

PSME4 (Proteasome Activator Subunit 4) is a Protein Coding gene. Among its related pathways are RET signaling and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include binding and peptidase activator activity.

UniProtKB/Swiss-Prot for PSME4 Gene

  • Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.

Gene Wiki entry for PSME4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSME4 Gene

Genomics for PSME4 Gene

Regulatory Elements for PSME4 Gene

Enhancers for PSME4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F053967 1.1 FANTOM5 ENCODE 5.4 +0.8 810 4.7 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS ZNF263 ACYP2 HMGB1P31 PSME4 ASB3 GPR75-ASB3
GH02F054767 0.5 Ensembl ENCODE 4.4 -797.1 -797088 1.6 MTA2 JUN JUNB POLR2H JUND ZNF366 IKZF1 EED ZNF24 PRDM1 LOC105374667 EML6 RTN4 SPTBN1 PSME4 GC02P054774
GH02F053738 0.6 FANTOM5 3.3 +231.7 231727 0.4 GPR75 PSME4 GC02P053747 GC02M053662
GH02F053993 1.5 FANTOM5 Ensembl ENCODE 2.3 -23.8 -23771 2.8 ZNF362 JUNB ZBTB33 ZNF781 ZNF518A ACYP2 HMGB1P31 ASB3 PSME4 GC02P053991 GC02P054007
GH02F053987 1 Ensembl ENCODE 0.3 -16.7 -16662 0.6 INSM2 FEZF1 ZNF2 ZEB1 ZNF366 SCRT2 ZNF391 ZNF362 OVOL3 JUNB ACYP2 GC02P053991 PSME4
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PSME4 on UCSC Golden Path with GeneCards custom track

Promoters for PSME4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000590440 640 4001 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS ZNF263

Genomic Location for PSME4 Gene

Chromosome:
2
Start:
53,864,067 bp from pter
End:
53,970,840 bp from pter
Size:
106,774 bases
Orientation:
Minus strand

Genomic View for PSME4 Gene

Genes around PSME4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSME4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSME4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSME4 Gene

Proteins for PSME4 Gene

  • Protein details for PSME4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14997-PSME4_HUMAN
    Recommended name:
    Proteasome activator complex subunit 4
    Protein Accession:
    Q14997
    Secondary Accessions:
    • Q1XBG4
    • Q1XBG5
    • Q1XBG6
    • Q2M1Z0
    • Q6IPR2
    • Q86XF8

    Protein attributes for PSME4 Gene

    Size:
    1843 amino acids
    Molecular mass:
    211334 Da
    Quaternary structure:
    • Homodimer. Interacts with the 20S and 26S proteasomes. Component of the spermatoproteasome, a form of the proteasome specifically found in testis.
    SequenceCaution:
    • Sequence=AAI12170.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI13669.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PSME4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSME4 Gene

Post-translational modifications for PSME4 Gene

  • Ubiquitination at Lys 916
  • Modification sites at PhosphoSitePlus

Other Protein References for PSME4 Gene

No data available for DME Specific Peptides for PSME4 Gene

Domains & Families for PSME4 Gene

Gene Families for PSME4 Gene

Protein Domains for PSME4 Gene

Suggested Antigen Peptide Sequences for PSME4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14997

UniProtKB/Swiss-Prot:

PSME4_HUMAN :
  • The bromodomain-like (BRDL) region specifically recognizes and binds acetylated histones.
  • Belongs to the BLM10 family.
  • Contains 6 HEAT repeats.
Domain:
  • The bromodomain-like (BRDL) region specifically recognizes and binds acetylated histones.
Family:
  • Belongs to the BLM10 family.
Similarity:
  • Contains 6 HEAT repeats.
genes like me logo Genes that share domains with PSME4: view

Function for PSME4 Gene

Molecular function for PSME4 Gene

UniProtKB/Swiss-Prot Function:
Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.

Gene Ontology (GO) - Molecular Function for PSME4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016504 peptidase activator activity IEA,ISS --
GO:0070577 lysine-acetylated histone binding IEA,ISS --
GO:0070628 proteasome binding IBA --
genes like me logo Genes that share ontologies with PSME4: view
genes like me logo Genes that share phenotypes with PSME4: view

Animal Models for PSME4 Gene

MGI Knock Outs for PSME4:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSME4 Gene

Localization for PSME4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSME4 Gene

Cytoplasm, cytosol. Nucleus. Nucleus speckle. Note=Found in nuclear foci following treatment with ionizing radiation, but not with ultraviolet irradiation or H(2)O(2).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSME4 Gene COMPARTMENTS Subcellular localization image for PSME4 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PSME4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA --
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005839 proteasome core complex IBA --
genes like me logo Genes that share ontologies with PSME4: view

Pathways & Interactions for PSME4 Gene

SuperPathways for PSME4 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
.78
.32
2 RET signaling
3 HIV Life Cycle
.45
4 Class I MHC mediated antigen processing and presentation
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with PSME4: view

Gene Ontology (GO) - Biological Process for PSME4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006281 DNA repair ISS --
genes like me logo Genes that share ontologies with PSME4: view

No data available for SIGNOR curated interactions for PSME4 Gene

Drugs & Compounds for PSME4 Gene

(2) Drugs for PSME4 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 794
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSME4: view

Transcripts for PSME4 Gene

Unigene Clusters for PSME4 Gene

Proteasome (prosome, macropain) activator subunit 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSME4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a ·
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

ExUns: 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47a · 47b · 47c ^
SP1: - - - - -
SP2:
SP3: - - - -
SP4: - -
SP5:
SP6:
SP7:
SP8:

ExUns: 48 ^ 49 ^ 50a · 50b · 50c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for PSME4 Gene

GeneLoc Exon Structure for
PSME4
ECgene alternative splicing isoforms for
PSME4

Expression for PSME4 Gene

mRNA expression in normal human tissues for PSME4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSME4 Gene

This gene is overexpressed in Muscle - Skeletal (x6.1).

Protein differential expression in normal tissues from HIPED for PSME4 Gene

This gene is overexpressed in Ovary (31.7) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSME4 Gene



Protein tissue co-expression partners for PSME4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSME4 Gene:

PSME4

SOURCE GeneReport for Unigene cluster for PSME4 Gene:

Hs.413801
genes like me logo Genes that share expression patterns with PSME4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PSME4 Gene

Orthologs for PSME4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PSME4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSME4 34 35
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia PSME4 34 35
  • 94.18 (n)
cow
(Bos Taurus)
Mammalia PSME4 34 35
  • 93.74 (n)
oppossum
(Monodelphis domestica)
Mammalia PSME4 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psme4 34 16 35
  • 91.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PSME4 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psme4 34
  • 90.78 (n)
chicken
(Gallus gallus)
Aves PSME4 34 35
  • 81.7 (n)
lizard
(Anolis carolinensis)
Reptilia PSME4 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psme4 34
  • 75.59 (n)
Str.11346 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25803 34
zebrafish
(Danio rerio)
Actinopterygii psme4a 35
  • 74 (a)
OneToMany
PSME4 (3 of 4) 35
  • 73 (a)
OneToMany
BX663524.3 35
  • 72 (a)
OneToMany
psme4b 34 35
  • 69.16 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002597 34
  • 44.25 (n)
worm
(Caenorhabditis elegans)
Secernentea C14C10.5 34 35
  • 45.12 (n)
T28B8.3 35
  • 21 (a)
OneToMany
T28B8.4 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
OneToOne
Species where no ortholog for PSME4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSME4 Gene

ENSEMBL:
Gene Tree for PSME4 (if available)
TreeFam:
Gene Tree for PSME4 (if available)

Paralogs for PSME4 Gene

No data available for Paralogs for PSME4 Gene

Variants for PSME4 Gene

Sequence variations from dbSNP and Humsavar for PSME4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10164409 -- 53,940,867(+) TAATA(C/T)ATATT intron-variant
rs10166829 -- 53,940,960(+) atata(A/C/T)atata intron-variant
rs10170468 -- 53,891,092(+) TAGTA(C/T)GCTAG intron-variant
rs10176892 -- 53,928,901(+) tggct(C/G)acacc intron-variant
rs10178001 -- 53,940,957(+) CATAT(A/T)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSME4 Gene

Variant ID Type Subtype PubMed ID
esv2484606 CNV deletion 19546169
esv2720077 CNV deletion 23290073
esv2720078 CNV deletion 23290073
esv2762257 CNV loss 21179565
esv3590830 CNV loss 21293372
esv3590831 CNV loss 21293372
nsv1001246 CNV gain 25217958
nsv1123326 CNV deletion 24896259
nsv829423 CNV loss 20364138

Variation tolerance for PSME4 Gene

Residual Variation Intolerance Score: 0.669% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.64; 94.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSME4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSME4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSME4 Gene

Disorders for PSME4 Gene

Relevant External Links for PSME4

Genetic Association Database (GAD)
PSME4
Human Genome Epidemiology (HuGE) Navigator
PSME4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSME4

No disorders were found for PSME4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSME4 Gene

Publications for PSME4 Gene

  1. PA200, a nuclear proteasome activator involved in DNA repair. (PMID: 12093752) Ustrell V. … Rechsteiner M. (EMBO J. 2002) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X. … Huang L. (Biochemistry 2007) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for PSME4 Gene

Sources for PSME4 Gene

Content
Loading form....