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Aliases for PSME4 Gene

Aliases for PSME4 Gene

  • Proteasome Activator Subunit 4 2 3 5
  • Proteasome (Prosome, Macropain) Activator Subunit 4 2 3
  • Proteasome Activator PA200 3 4
  • Proteasome Activator 200 KDa 3
  • KIAA0077 4
  • PA200 3

External Ids for PSME4 Gene

Previous GeneCards Identifiers for PSME4 Gene

  • GC02M054048
  • GC02M054066
  • GC02M054003
  • GC02M054091
  • GC02M053825

Summaries for PSME4 Gene

GeneCards Summary for PSME4 Gene

PSME4 (Proteasome Activator Subunit 4) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include binding and peptidase activator activity.

UniProtKB/Swiss-Prot for PSME4 Gene

  • Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.

Gene Wiki entry for PSME4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSME4 Gene

Genomics for PSME4 Gene

Regulatory Elements for PSME4 Gene

Promoters for PSME4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSME4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSME4 Gene

Chromosome:
2
Start:
53,864,067 bp from pter
End:
53,970,840 bp from pter
Size:
106,774 bases
Orientation:
Minus strand

Genomic View for PSME4 Gene

Genes around PSME4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSME4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSME4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSME4 Gene

Proteins for PSME4 Gene

  • Protein details for PSME4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14997-PSME4_HUMAN
    Recommended name:
    Proteasome activator complex subunit 4
    Protein Accession:
    Q14997
    Secondary Accessions:
    • Q1XBG4
    • Q1XBG5
    • Q1XBG6
    • Q2M1Z0
    • Q6IPR2
    • Q86XF8

    Protein attributes for PSME4 Gene

    Size:
    1843 amino acids
    Molecular mass:
    211334 Da
    Quaternary structure:
    • Homodimer. Interacts with the 20S and 26S proteasomes. Component of the spermatoproteasome, a form of the proteasome specifically found in testis.
    SequenceCaution:
    • Sequence=AAI12170.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI13669.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PSME4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSME4 Gene

Proteomics data for PSME4 Gene at MOPED

Post-translational modifications for PSME4 Gene

  • Ubiquitination at Lys 916
  • Modification sites at PhosphoSitePlus

Other Protein References for PSME4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PSME4 Gene

Domains & Families for PSME4 Gene

Gene Families for PSME4 Gene

Protein Domains for PSME4 Gene

Suggested Antigen Peptide Sequences for PSME4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14997

UniProtKB/Swiss-Prot:

PSME4_HUMAN :
  • The bromodomain-like (BRDL) region specifically recognizes and binds acetylated histones.
  • Belongs to the BLM10 family.
  • Contains 6 HEAT repeats.
Domain:
  • The bromodomain-like (BRDL) region specifically recognizes and binds acetylated histones.
Family:
  • Belongs to the BLM10 family.
Similarity:
  • Contains 6 HEAT repeats.
genes like me logo Genes that share domains with PSME4: view

Function for PSME4 Gene

Molecular function for PSME4 Gene

UniProtKB/Swiss-Prot Function:
Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.
genes like me logo Genes that share phenotypes with PSME4: view

Animal Models for PSME4 Gene

MGI Knock Outs for PSME4:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSME4 Gene

Localization for PSME4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSME4 Gene

Cytoplasm, cytosol. Nucleus. Nucleus speckle. Note=Found in nuclear foci following treatment with ionizing radiation, but not with ultraviolet irradiation or H(2)O(2).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSME4 Gene COMPARTMENTS Subcellular localization image for PSME4 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for PSME4 Gene

Pathways & Interactions for PSME4 Gene

SuperPathways for PSME4 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin-3, 5 and GM-CSF signaling
3 Infectious disease
.48
4 Immune System
5 Cell Cycle, Mitotic
.61
genes like me logo Genes that share pathways with PSME4: view

Pathways by source for PSME4 Gene

1 KEGG pathway for PSME4 Gene

Gene Ontology (GO) - Biological Process for PSME4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with PSME4: view

No data available for SIGNOR curated interactions for PSME4 Gene

Drugs & Compounds for PSME4 Gene

(2) Drugs for PSME4 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 769
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSME4: view

Transcripts for PSME4 Gene

Unigene Clusters for PSME4 Gene

Proteasome (prosome, macropain) activator subunit 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSME4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a ·
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

ExUns: 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47a · 47b · 47c ^
SP1: - - - - -
SP2:
SP3: - - - -
SP4: - -
SP5:
SP6:
SP7:
SP8:

ExUns: 48 ^ 49 ^ 50a · 50b · 50c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for PSME4 Gene

GeneLoc Exon Structure for
PSME4
ECgene alternative splicing isoforms for
PSME4

Expression for PSME4 Gene

mRNA expression in normal human tissues for PSME4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSME4 Gene

This gene is overexpressed in Muscle - Skeletal (x6.1).

Protein differential expression in normal tissues from HIPED for PSME4 Gene

This gene is overexpressed in Ovary (31.7) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSME4 Gene



SOURCE GeneReport for Unigene cluster for PSME4 Gene Hs.413801

genes like me logo Genes that share expression patterns with PSME4: view

Protein tissue co-expression partners for PSME4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PSME4 Gene

Orthologs for PSME4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PSME4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSME4 36
  • 100 (a)
OneToOne
PSME4 35
  • 99.6 (n)
  • 99.57 (a)
cow
(Bos Taurus)
Mammalia PSME4 35
  • 93.74 (n)
  • 97.07 (a)
PSME4 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSME4 36
  • 97 (a)
OneToOne
PSME4 35
  • 94.18 (n)
  • 97.57 (a)
mouse
(Mus musculus)
Mammalia Psme4 36
  • 96 (a)
OneToOne
Psme4 16
Psme4 35
  • 91.12 (n)
  • 95.71 (a)
oppossum
(Monodelphis domestica)
Mammalia PSME4 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSME4 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psme4 35
  • 90.78 (n)
  • 95.77 (a)
chicken
(Gallus gallus)
Aves PSME4 35
  • 81.7 (n)
  • 89.53 (a)
PSME4 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSME4 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25803 35
tropical clawed frog
(Silurana tropicalis)
Amphibia psme4 35
  • 75.59 (n)
  • 83.43 (a)
Str.11346 35
zebrafish
(Danio rerio)
Actinopterygii BX663524.3 36
  • 72 (a)
OneToMany
PSME4 (3 of 4) 36
  • 73 (a)
OneToMany
psme4a 36
  • 74 (a)
OneToMany
psme4b 36
  • 77 (a)
OneToMany
psme4b 35
  • 69.16 (n)
  • 78.21 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002597 35
  • 44.25 (n)
  • 36.52 (a)
worm
(Caenorhabditis elegans)
Secernentea C14C10.5 35
  • 45.12 (n)
  • 33.43 (a)
C14C10.5 36
  • 29 (a)
OneToMany
T28B8.3 36
  • 21 (a)
OneToMany
T28B8.4 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for PSME4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSME4 Gene

ENSEMBL:
Gene Tree for PSME4 (if available)
TreeFam:
Gene Tree for PSME4 (if available)

Paralogs for PSME4 Gene

No data available for Paralogs for PSME4 Gene

Variants for PSME4 Gene

Sequence variations from dbSNP and Humsavar for PSME4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2302878 - 53,908,799(+) CCTTA(C/T)AACTG nc-transcript-variant, reference, missense
rs805408 - 53,892,888(+) ATGTG(A/T)ATCTG nc-transcript-variant, reference, missense
rs35903236 - 53,866,148(-) AATTC(A/G)CTGAT nc-transcript-variant, reference, missense
rs718872 -- 53,946,569(+) TACAA(A/T)CAAAG intron-variant
rs727832 -- 53,951,484(+) AAGCT(A/G)GTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSME4 Gene

Variant ID Type Subtype PubMed ID
esv2720077 CNV Deletion 23290073
esv2484606 CNV Deletion 19546169
nsv829423 CNV Loss 20364138
esv2720078 CNV Deletion 23290073

Variation tolerance for PSME4 Gene

Residual Variation Intolerance Score: 0.669% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.64; 94.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSME4 Gene

HapMap Linkage Disequilibrium report
PSME4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSME4 Gene

Disorders for PSME4 Gene

Relevant External Links for PSME4

Genetic Association Database (GAD)
PSME4
Human Genome Epidemiology (HuGE) Navigator
PSME4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSME4

No disorders were found for PSME4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSME4 Gene

Publications for PSME4 Gene

  1. PA200, a nuclear proteasome activator involved in DNA repair. (PMID: 12093752) Ustrell V. … Rechsteiner M. (EMBO J. 2002) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for PSME4 Gene

Sources for PSME4 Gene

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