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Aliases for PSME3 Gene

Aliases for PSME3 Gene

  • Proteasome (Prosome, Macropain) Activator Subunit 3 (PA28 Gamma; Ki) 2 3
  • PA28G 3 4 6
  • Activator Of Multicatalytic Protease Subunit 3 3 4
  • Proteasome Activator 28 Subunit Gamma 3 4
  • 11S Regulator Complex Subunit Gamma 3 4
  • Ki Nuclear Autoantigen 3 4
  • REG-GAMMA 3 4
  • PA28gamma 3 4
  • Proteasome Activator Complex Subunit 3 3
  • 11S Regulator Complex Gamma Subunit 3
  • Epididymis Secretory Protein Li 283 3
  • Proteasome Activator 28-Gamma 3
  • PA28 Gamma Variant 5 3
  • REG Gamma-3 3
  • Ki Antigen 3
  • PA28-Gamma 3
  • HEL-S-283 3
  • Ki 3

External Ids for PSME3 Gene

Previous GeneCards Identifiers for PSME3 Gene

  • GC17M040635
  • GC17P043138
  • GC17P040885
  • GC17P041358
  • GC17P038238
  • GC17P040985
  • GC17P036749

Summaries for PSME3 Gene

Entrez Gene Summary for PSME3 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

GeneCards Summary for PSME3 Gene

PSME3 (Proteasome (Prosome, Macropain) Activator Subunit 3 (PA28 Gamma; Ki)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Downstream Signaling Events Of B Cell Receptor (BCR). GO annotations related to this gene include p53 binding and MDM2/MDM4 family protein binding. An important paralog of this gene is PSME1.

UniProtKB/Swiss-Prot for PSME3 Gene

  • Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.

Gene Wiki entry for PSME3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSME3 Gene

Genomics for PSME3 Gene

Regulatory Elements for PSME3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PSME3 Gene

Start:
42,824,385 bp from pter
End:
42,843,760 bp from pter
Size:
19,376 bases
Orientation:
Plus strand

Genomic View for PSME3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSME3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSME3 Gene

Proteins for PSME3 Gene

  • Protein details for PSME3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61289-PSME3_HUMAN
    Recommended name:
    Proteasome activator complex subunit 3
    Protein Accession:
    P61289
    Secondary Accessions:
    • A8K9A3
    • O35563
    • P97373
    • Q12920
    • Q13172
    • Q9BQD9

    Protein attributes for PSME3 Gene

    Size:
    254 amino acids
    Molecular mass:
    29506 Da
    Quaternary structure:
    • Homoheptamer; the stability of the heptamer is essential for the specific activation of the trypsine-like subunit and inhibition of the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits of the proteasome. Interacts with p53/TP53 and MDM2. Interacts with MAP3K3 (By similarity). Associates with the proteasome.

    Alternative splice isoforms for PSME3 Gene

neXtProt entry for PSME3 Gene

Proteomics data for PSME3 Gene at MOPED

Post-translational modifications for PSME3 Gene

  • Acetylation at the major site Lys-195 is important for oligomerization and ability to degrade its target substrates. Deacetylated by SIRT1.
  • Phosphorylated by MAP3K3.
  • Ubiquitination at Lys6, Lys14, Lys37, Lys100, Lys110, Lys121, and Lys195
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSME3 (PSME3)

Protein Products

No data available for DME Specific Peptides for PSME3 Gene

Domains for PSME3 Gene

Gene Families for PSME3 Gene

HGNC:
  • PSM :Proteasome (prosome, macropain) subunits

Graphical View of Domain Structure for InterPro Entry

P61289

UniProtKB/Swiss-Prot:

PSME3_HUMAN :
  • P61289
Domain:
  • The C-terminal sequences affect heptamer stability and proteasome affinity.
Family:
  • Belongs to the PA28 family.
genes like me logo Genes that share domains with PSME3: view

Function for PSME3 Gene

Molecular function for PSME3 Gene

GENATLAS Biochemistry: proteasome (prosome,macropain) activator subunit 3 (PA28-gamma)
UniProtKB/Swiss-Prot Function: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.
UniProtKB/Swiss-Prot Induction: Up-regulated in thyroid carcinoma cells.

Gene Ontology (GO) - Molecular Function for PSME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IDA 18309296
GO:0005515 protein binding IPI 12970408
GO:0042802 identical protein binding IPI 16169070
GO:0061133 endopeptidase activator activity IDA 18309296
GO:0097371 MDM2/MDM4 family protein binding IDA 18309296
genes like me logo Genes that share ontologies with PSME3: view
genes like me logo Genes that share phenotypes with PSME3: view

Animal Models for PSME3 Gene

MGI Knock Outs for PSME3:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSME3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PSME3 Gene

Localization for PSME3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSME3 Gene

Nucleus. Cytoplasm. Note=Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSME3 Gene COMPARTMENTS Subcellular localization image for PSME3 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PSME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS 8811196
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSME3: view

Pathways for PSME3 Gene

SuperPathways for PSME3 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.38
2 Class I MHC mediated antigen processing and presentation
3 Cell Cycle, Mitotic
.62
4 Mitotic Metaphase and Anaphase
5 Downstream Signaling Events Of B Cell Receptor (BCR)
genes like me logo Genes that share pathways with PSME3: view

Pathways by source for PSME3 Gene

1 Cell Signaling Technology pathway for PSME3 Gene
1 BioSystems pathway for PSME3 Gene
1 GeneGo (Thomson Reuters) pathway for PSME3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PSME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSME3: view

Transcripts for PSME3 Gene

Unigene Clusters for PSME3 Gene

Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSME3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSME3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - -
SP2: - - - -
SP3: -
SP4: -
SP5: - - -
SP6: - - - - - -
SP7: - - - -
SP8: -
SP9: - - - - - - -
SP10:
SP11:

Relevant External Links for PSME3 Gene

GeneLoc Exon Structure for
PSME3
ECgene alternative splicing isoforms for
PSME3

Expression for PSME3 Gene

mRNA expression in normal human tissues for PSME3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSME3 Gene

SOURCE GeneReport for Unigene cluster for PSME3 Gene Hs.152978

genes like me logo Genes that share expressions with PSME3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSME3 Gene

Orthologs for PSME3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PSME3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSME3 35
  • 99.74 (n)
  • 99.61 (a)
PSME3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSME3 35
  • 96.59 (n)
  • 100 (a)
PSME3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSME3 35
  • 94.13 (n)
  • 97 (a)
PSME3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psme3 35
  • 94.09 (n)
  • 100 (a)
Psme3 16
Psme3 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSME3 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psme3 35
  • 94.62 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves PSME3 35
  • 85.96 (n)
  • 96.46 (a)
PSME3 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia psme3 35
  • 77.3 (n)
  • 92.13 (a)
Str.3210 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10191 35
zebrafish
(Danio rerio)
Actinopterygii psme3 35
  • 73.62 (n)
  • 80.71 (a)
psme3 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000308 35
  • 54.43 (n)
  • 48.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta REG 35
  • 54.95 (n)
  • 49.37 (a)
REG 36
  • 47 (a)
OneToMany
REG 37
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea Y66D12A.9 35
  • 53.22 (n)
  • 52.36 (a)
Y66D12A.9 36
  • 48 (a)
OneToMany
Y66D12A.9 37
  • 48 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.73 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9143 36
  • 53 (a)
OneToOne
Species with no ortholog for PSME3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSME3 Gene

ENSEMBL:
Gene Tree for PSME3 (if available)
TreeFam:
Gene Tree for PSME3 (if available)

Paralogs for PSME3 Gene

Paralogs for PSME3 Gene

Selected SIMAP similar genes for PSME3 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for PSME3 Gene

genes like me logo Genes that share paralogs with PSME3: view

Variants for PSME3 Gene

Sequence variations from dbSNP and Humsavar for PSME3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs190120 -- 42,836,225(-) gagtt(C/G/T)gagac intron-variant
rs380455 -- 42,836,215(-) ccagt(C/T)tggac intron-variant
rs471762 -- 42,836,218(-) agacc(A/G)gcctg intron-variant
rs593648 -- 42,831,190(-) ACTTA(A/C)CAATA upstream-variant-2KB
rs599910 -- 42,840,987(-) cccgg(A/C)taatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSME3 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
nsv483009 CNV Gain 15286789

Relevant External Links for PSME3 Gene

HapMap Linkage Disequilibrium report
PSME3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSME3 Gene

Disorders for PSME3 Gene

(1) Novoseek inferred disease relationships for PSME3 Gene

Disease -log(P) Hits PubMed IDs
lupus erythematosus systemic 45.8 2
genes like me logo Genes that share disorders with PSME3: view

No data available for UniProtKB/Swiss-Prot for PSME3 Gene

Publications for PSME3 Gene

  1. Cloning and nucleotide sequence of cDNA for Ki antigen, a highly conserved nuclear protein detected with sera from patients with systemic lupus erythematosus. (PMID: 1968796) Nikaido T. … Nishida Y. (Clin. Exp. Immunol. 1990) 3 4 23
  2. A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21. (PMID: 7951316) Albertsen H.M. … White R. (Nat. Genet. 1994) 2 3 4
  3. REGgamma proteasome activator is involved in the maintenance of chromosomal stability. (PMID: 18235248) Zannini L. … Delia D. (Cell Cycle 2008) 3 23
  4. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. (PMID: 7545954) Miki Y. … Skolnick M.H. (Science 1994) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PSME3 Gene

Sources for PSME3 Gene

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