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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PSME3 Gene

protein-coding   GIFtS: 66
GCID: GC17P040985

Proteasome (Prosome, Macropain) Activator Subunit 3 (PA28...

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Proteasome (Prosome, Macropain) Activator Subunit 3 (PA28 Gamma;
Ki)1 2
     PA28-gamma2
Activator Of Multicatalytic Protease Subunit 32 3     REG-GAMMA2
Proteasome Activator 28 Subunit Gamma2 3     Ki Antigen2
11S Regulator Complex Subunit Gamma2 3     PA28 Gamma Variant 52
PA28gamma2 3     Proteasome Activator 28-Gamma2
Ki Nuclear Autoantigen2 3     Proteasome Activator Complex Subunit 32
PA28G2 5     PA28g3
11S Regulator Complex Gamma Subunit2     REG-gamma3
Ki2     

External Ids:    HGNC: 95701   Entrez Gene: 101972   Ensembl: ENSG000001314677   OMIM: 6051295   UniProtKB: P612893   

Export aliases for PSME3 gene to outside databases

Previous GC identifers: GC17M040635 GC17P043138 GC17P040885 GC17P041358 GC17P038238 GC17P036749


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PSME3 Gene:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes,
a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are
composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a
base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in
an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome,
the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate
regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta
and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator.
Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript
variants. (provided by RefSeq, May 2012)

GeneCards Summary for PSME3 Gene: 
PSME3 (proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)) is a protein-coding gene. Diseases associated with PSME3 include connective tissue disease, and ataxia telangiectasia, and among its related super-pathways are Regulation of APC/C activators between G1/S and early anaphase and Mitotic Anaphase. GO annotations related to this gene include endopeptidase activator activity and p53 binding. An important paralog of this gene is PSME2.

UniProtKB/Swiss-Prot: PSME3_HUMAN, P61289
Function: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped
homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of
the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the
MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53,
limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell
cycle regulation

Gene Wiki entry for PSME3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PSME3 gene promoter:
         GR   p53   AP-1   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PSME3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PSME3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSME3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q12-q21

PSME3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSME3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P040985:  view genomic region     (about GC identifiers)

Start:
40,976,402 bp from pter      End:
40,995,777 bp from pter
Size:
19,376 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PSME3_HUMAN, P61289 (See protein sequence)
Recommended Name: Proteasome activator complex subunit 3  
Size: 254 amino acids; 29506 Da
Subunit: Homoheptamer; the stability of the heptamer is essential for the specific activation of the trypsine-like
subunit and inhibition of the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits of the proteasome.
Interacts with p53/TP53 and MDM2. Interacts with MAP3K3 (By similarity). Associates with the proteasome
Subcellular location: Nucleus. Cytoplasm (By similarity). Note=Localizes to the cytoplasm during mitosis following
nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3
kinase (By similarity)
Secondary accessions: A8K9A3 O35563 P97373 Q12920 Q13172 Q9BQD9
Alternative splicing: 2 isoforms:  P61289-1, Q12920-1   P61289-2, Q12920-2   

Explore the universe of human proteins at neXtProt for PSME3: NX_P61289

Explore proteomics data for PSME3 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by MAP3K3 (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P61289

  • PSME3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PSME3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001253974.1  NP_005780.2  NP_789839.1  

    ENSEMBL proteins: 
     ENSP00000441682   ENSP00000467580   ENSP00000466794   ENSP00000466451   ENSP00000409487  
     ENSP00000465743   ENSP00000466945   ENSP00000437924   ENSP00000293362   ENSP00000468702  
     ENSP00000465155   ENSP00000438237  
    Reactome Protein details: P61289
    Human Recombinant Protein Products for PSME3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for PSME3 (PA28 Activator gamma Subunit)
    Enzo Life Sciences proteins for PSME3
    OriGene Purified Protein for PSME3
    OriGene Protein Over-expression Lysate for PSME3
    OriGene MassSpec for PSME3 
    OriGene Custom Protein Services for PSME3
    GenScript Custom Purified and Recombinant Proteins Services for PSME3
    Novus Biologicals PSME3 Proteins
    Novus Biologicals PSME3 Lysates
    Sino Biological Recombinant Protein for PSME3
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PSME3
    Cloud-Clone Corp. Proteins for PSME3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex TAS8811196
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0008537proteasome activator complex IEA--

    PSME3 for ontologies           About GeneDecksing



    PSME3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals PSME3 Antibodies
    Abcam antibodies for PSME3
    Cloud-Clone Corp. Antibodies for PSME3 
    ThermoFisher Antibody for PSME3
    LSBio Antibodies in human, mouse, rat for PSME3 

    Assay Products for PSME3: 
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    Cloud-Clone Corp. ELISAs for PSME3 
    Cloud-Clone Corp. CLIAs for PSME3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PSM: Proteasome (prosome, macropain) subunits

    3 InterPro protein domains:
     IPR003186 Proteasome_activ_REG_bsu
     IPR003185 Proteasome_activ_REG_asu
     IPR009077 Proteasome_activ_REG_asu/bsu

    Graphical View of Domain Structure for InterPro Entry P61289

    ProtoNet protein and cluster: P61289

    1 Blocks protein domain: IPB003185 Proteasome activator pa28

    UniProtKB/Swiss-Prot: PSME3_HUMAN, P61289
    Domain: The C-terminal sequences affect heptamer stability and proteasome affinity
    Similarity: Belongs to the PA28 family


    PSME3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PSME3_HUMAN, P61289
    Function: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped
    homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of
    the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the
    MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53,
    limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell
    cycle regulation
    Induction: Up-regulated in thyroid carcinoma cells

         Genatlas biochemistry entry for PSME3:
    proteasome (prosome,macropain) activator subunit 3 (PA28-gamma)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IDA18309296
    GO:0005515protein binding IPI16439211
    GO:0061133endopeptidase activator activity IDA18309296
    GO:0097371MDM2/MDM4 family protein binding IDA18309296
         
    PSME3 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Psme3):
     cellular  growth/size  hematopoietic system  immune system 

    PSME3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PSME3: Psme3tm1Tchi Psme3tm1Jjm

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PSME3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PSME3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PSME3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PSME3 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PSME3:
    hsa-mir-7 (MIRT004063)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSME3
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate PSME3 (see all 58):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-549 hsa-miR-328 hsa-miR-379* hsa-miR-548k hsa-miR-15a hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidPSME3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PSME3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSME3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PSME3
    Sirion Biotech Customized adenovirus for overexpression of PSME3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PSME3 (see all 14)
    OriGene ORF clones in mouse, rat for PSME3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PSME3 (NM_176863)
    Sino Biological Human cDNA Clone for PSME3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSME3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSME3
    Sirion Biotech Customized lentivirus for stable overexpression of PSME3 
                         Customized lentivirus expression plasmids for stable overexpression of PSME3 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PSME3
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSME3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PSME3 About   (see all 19)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    APC/C:Cdc20 mediated degradation of mitotic proteins0.94
    Removal of licensing factors from origins0.89
    Cdc20:Phospho-APC/C mediated degradation of Cyclin A0.94
    Regulation of DNA replication0.89
    CDK-mediated phosphorylation and removal of Cdc60.94
    Cyclin E associated events during G1/S transition 0.89
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    Switching of origins to a post-replicative state0.89
    2M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    3Metabolism of mRNA
    Metabolism of RNA0.92
    Metabolism of mRNA0.92
    4Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    5Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Class I MHC mediated antigen processing & presentation0.83

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PSME3
        Immune response Antigen presentation by MHC class I


    1 Cell Signaling Technology (CST) Pathway for PSME3
        Protein Stability

    1 GeneGo (Thomson Reuters) Pathway for PSME3
        Immune response Antigen presentation by MHC class I

    1 BioSystems Pathway for PSME3
        Proteasome Degradation


    5/74        Reactome Pathways for PSME3 (see all 74)
        Orc1 removal from chromatin
    CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway
    CDT1 association with the CDC6:ORC:origin complex
    Autodegradation of the E3 ubiquitin ligase COP1


    3         Kegg Pathways  (Kegg details for PSME3):
        Proteasome
    Antigen processing and presentation
    Hepatitis C


    PSME3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PSME3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/183 Interacting proteins for PSME3 (P612891, 2, 3 ENSP000002933624) via UniProtKB, MINT, STRING, and/or I2D (see all 183)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009872, 3, ENSP000004172814MINT-6540807 MINT-6540920 MINT-6540776 MINT-6540837 MINT-6540985 MINT-6540853 MINT-6540796 MINT-6540998 MINT-6540973 I2D: score=3 STRING: ENSP00000417281
    TP53P046372, 3, ENSP000002693054MINT-6540807 MINT-6540940 MINT-6540866 MINT-6540920 MINT-6540876 MINT-6540776 MINT-6541016 MINT-6540960 MINT-6540796 I2D: score=3 STRING: ENSP00000269305
    COILP384321, 2, 3, ENSP000002403164EBI-355546,EBI-945751 MINT-2868141 MINT-2868160 I2D: score=3 STRING: ENSP00000240316
    SMURF1Q9HCE72, 3, ENSP000003546214MINT-7894494 MINT-7894481 MINT-7894523 MINT-7894558 MINT-7894543 I2D: score=2 STRING: ENSP00000354621
    ATP5BP065762, 3, ENSP000002620304MINT-63935 I2D: score=5 STRING: ENSP00000262030
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--

    PSME3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PSME3

    Search CenterWatch for drugs/clinical trials and news about PSME3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PSME3 gene (3 alternative transcripts): 
    NM_001267045.1  NM_005789.3  NM_176863.2  

    Unigene Cluster for PSME3:

    Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
    Hs.152978  [show with all ESTs]
    Unigene Representative Sequence: NM_001267045
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592458 ENST00000545225(uc002ibp.3) ENST00000586114 ENST00000590720
    ENST00000585805 ENST00000592578 ENST00000441946(uc002ibr.3 uc002ibs.3 uc010whd.2)
    ENST00000591152 ENST00000589469 ENST00000591722 ENST00000543428 ENST00000293362(uc002ibq.3)
    ENST00000592169 ENST00000586312 ENST00000593111 ENST00000541124
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSME3
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate PSME3 (see all 58):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-549 hsa-miR-328 hsa-miR-379* hsa-miR-548k hsa-miR-15a hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidPSME3 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): PSME3 (NM_176863)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSME3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSME3
    Sirion Biotech Customized lentivirus for stable overexpression of PSME3 
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    Primer
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    OriGene qPCR primer pairs and template standards for PSME3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSME3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSME3

    Additional mRNA sequence: 

    AK057221.1 AK074999.1 AK292618.1 AK303211.1 AK307110.1 AK314347.1 BC001423.2 BC002684.1 
    BC008020.1 BT019386.1 CR541745.1 FJ200488.1 JX156303.1 NR_049772.1 U11292.1 

    24 DOTS entries:

    DT.100877015  DT.100877011  DT.456118  DT.100877010  DT.95107611  DT.95169537  DT.100801837  DT.99955026 
    DT.100877022  DT.121006646  DT.100877014  DT.100877016  DT.121006638  DT.121006679  DT.91777635  DT.101977223 
    DT.102828673  DT.121006641  DT.121006747  DT.121006748  DT.99928402  DT.100877009  DT.121006693  DT.91777652 

    24/626 AceView cDNA sequences (see all 626):

    BE269188 CA454353 AW848201 AA309801 H23876 AA100392 BM672227 BE397021 
    BQ071643 AW950992 CF142104 BM800306 AU280332 BU154778 BM983497 BE269650 
    BQ684681 AW376711 AA903540 AA903713 AA915876 AA381850 BM791321 BX346292 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for PSME3 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
    SP1:                                                  -                 -                                                         
    SP2:                                                  -     -     -     -                                                         
    SP3:                                                  -                                                                           
    SP4:                                                  -                                                                           
    SP5:                                                  -                 -     -                                                   


    ECgene alternative splicing isoforms for PSME3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PSME3 expression in normal human tissues (normalized intensities)      PSME3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAGAAATT
    PSME3 Expression
    About this image


    PSME3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See PSME3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PSME3

    SOURCE GeneReport for Unigene cluster: Hs.152978
        SABiosciences Expression via Pathway-Focused PCR Array including PSME3: 
              Hepatotoxicity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PSME3 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Psme31 , 5 proteaseome (prosome, macropain) 28 subunit, 31, 5 94.09(n)1
    100(a)1
      11 (64.67 cM)5
    191921  NM_011192.31  NP_035322.11 
     1013162135 
    chicken
    (Gallus gallus)
    Aves PSME31 proteasome (prosome, macropain) activator subunit 3 more 85.96(n)
    96.46(a)
      420017  NM_001012550.1  NP_001012568.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    96(a)
    73(a)
    1 ↔ many
    1 ↔ many
    6(62293798-62314400)
    2(154785916-154786665)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ737418.12   -- 77.22(n)    BQ737418.1 
    zebrafish
    (Danio rerio)
    Actinopterygii psme32 proteasome activator subunit 3 75.51(n)   30649  BC045495.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta REG1 , 3 CG1591-PA1 46(a)3
    54.95(n)1
    49.37(a)1
      11E33
    322741  NM_132638.21  NP_572866.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y66D12A.91 , 3 Protein Y66D12A.91 48(a)3
    53.22(n)1
    52.36(a)1
      III(11639787-11644820)3
    1765881  NM_067092.31  NP_499493.11 


    ENSEMBL Gene Tree for PSME3 (if available)
    TreeFam Gene Tree for PSME3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PSME3 gene
    PSME22  PSME12  
    2 SIMAP similar genes for PSME3 using alignment to 10 protein entries:     PSME3_HUMAN (see all proteins):
    PSME1    PSME2

    PSME3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PSME3
    PGOHUM00000245048


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/252 SNPs in PSME3 are shown (see all 252)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs5936481,2
    C,F,H--40983207(-) ACTTAA/CCAATA 4 -- us2k110Minor allele frequency- C:0.01NS EA NA CSA WA 922
    rs1871140081,2
    --40983305(+) AAGAGA/TATGTG 4 -- us2k10--------
    rs799236101,2
    C,F--40983327(+) TAACCT/CACTTG 4 -- us2k11Minor allele frequency- C:0.09WA 118
    rs1457522851,2
    C--40983397(+) AGCTTG/TTCCAG 4 -- us2k10--------
    rs1929561431,2
    --40983411(+) ATGTTA/GTAAAT 4 -- us2k10--------
    rs1846161591,2
    --40983750(+) TTATTC/TCTAAT 4 -- us2k10--------
    rs1902805631,2
    --40983751(+) TATTTC/GTAATA 4 -- us2k10--------
    rs37602081,2
    C,F,A,H--40983813(+) TCCATC/TTTACA 4 -- us2k118Minor allele frequency- T:0.21NS EA NA WA CSA 1894
    rs1814766381,2
    --40983869(+) CCAGTC/TAGTAA 4 -- us2k10--------
    rs1850952981,2
    --40984021(+) AGCAAC/GAGCGA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for PSME3 (40976402 - 40995777 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PSME3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv483009CNV Gain15286789
    esv33998OTHER Inversion15654335

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605129    OMIM disorders: --

    16 diseases for PSME3:    About MalaCards
    connective tissue disease    ataxia telangiectasia    lupus erythematosus    hepatitis c
    huntington's disease    meningioma    ataxia    b-cell lymphomas
    systemic lupus erythematosus    ovarian cancer    schizophrenia    thyroiditis
    hepatitis    colorectal cancer    breast cancer    neuronitis


    PSME3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PSME3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lupus erythematosus systemic 45.8 2 1968796 (2)


    Export disorders for PSME3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PSME3 gene, integrated from 9 sources (see all 130):
    (articles sorted by number of sources associating them with PSME3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21. (PubMed id 7951316)1, 2, 3 Albertsen H.M....White R. (1994)
    2. Cloning and nucleotide sequence of cDNA for Ki antigen, a highly conserved nuclear protein detected with sera from patients with systemic lupus erythematosus. (PubMed id 1968796)1, 2, 9 Nikaido T.... Nishida Y. (1990)
    3. Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2- mediated degradation. (PubMed id 18309296)1, 2 Zhang Z. and Zhang R. (2008)
    4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. (PubMed id 7545954)1, 2 Miki Y.... Skolnick M.H. (1994)
    8. REGgamma proteasome activator is involved in the maintenance of chromosomal stability. (PubMed id 18235248)1, 9 Zannini L....Delia D. (2008)
    9. Properties of the nuclear proteasome activator PA28gamma (REGgamma). (PubMed id 11185562)2, 9 Wilk S.... Magnusson R.P. (2000)
    10. The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome. (PubMed id 16439211)1, 9 Li X....O'Malley B.W. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10197 HGNC: 9570 AceView: PSME3 Ensembl:ENSG00000131467 euGenes: HUgn10197
    ECgene: PSME3 Kegg: 10197 H-InvDB: PSME3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PSME3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PSME3 gene:
    Search GeneIP for patents involving PSME3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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