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Aliases for PSME3 Gene

Aliases for PSME3 Gene

  • Proteasome Activator Subunit 3 2 3 5
  • Proteasome (Prosome, Macropain) Activator Subunit 3 (PA28 Gamma; Ki) 2 3
  • Activator Of Multicatalytic Protease Subunit 3 3 4
  • Proteasome Activator 28 Subunit Gamma 3 4
  • 11S Regulator Complex Subunit Gamma 3 4
  • Ki Nuclear Autoantigen 3 4
  • REG-GAMMA 3 4
  • PA28gamma 3 4
  • PA28G 3 4
  • Proteasome Activator Complex Subunit 3 3
  • 11S Regulator Complex Gamma Subunit 3
  • Epididymis Secretory Protein Li 283 3
  • Proteasome Activator 28-Gamma 3
  • PA28 Gamma Variant 5 3
  • REG Gamma-3 3
  • Ki Antigen 3
  • PA28-Gamma 3
  • HEL-S-283 3
  • Ki 3

External Ids for PSME3 Gene

Previous GeneCards Identifiers for PSME3 Gene

  • GC17M040635
  • GC17P043138
  • GC17P040885
  • GC17P041358
  • GC17P038238
  • GC17P040985
  • GC17P036749

Summaries for PSME3 Gene

Entrez Gene Summary for PSME3 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

GeneCards Summary for PSME3 Gene

PSME3 (Proteasome Activator Subunit 3) is a Protein Coding gene. Among its related pathways are RET signaling and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include identical protein binding and MDM2/MDM4 family protein binding. An important paralog of this gene is PSME1.

UniProtKB/Swiss-Prot for PSME3 Gene

  • Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978).

Gene Wiki entry for PSME3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSME3 Gene

Genomics for PSME3 Gene

Regulatory Elements for PSME3 Gene

Enhancers for PSME3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F043366 1.3 Ensembl ENCODE 20.7 +544.8 544768 4.9 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF302 NBR2 DHX8 ASB16-AS1 HMGN1P29 LINC00910 PSME3 NBR1 ENSG00000267604 ENSG00000267340 RN7SL507P
GH17F042623 1.2 Ensembl ENCODE 12.2 -200.2 -200182 1.9 PKNOX1 ARNT GTF3C2 GATA2 ZNF143 FOS NCOA1 JUNB REST MBD2 DHX8 TUBG2 HMGN1P29 VPS25 FAM134C PSME3 ENSG00000267758 LINC00910 WNK4 ATP5LP7
GH17F043700 0.5 Ensembl ENCODE 12.2 +876.7 876738 1.4 ZFP64 SIN3A FEZF1 DMAP1 YY1 GTF3C2 SLC30A9 ZNF121 GLIS2 FOS SOST DHX8 HMGN1P29 ASB16-AS1 VPS25 PSME3 LINC00910 MEOX1 WHSC1L2P LOC105371786
GH17F042772 0.4 ENCODE 10.5 -50.0 -49971 4.0 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 HMGN2P15 LINC00910 AOC4P CNTNAP1 MEOX1 DHX8 HMGN1P29 RAMP2-AS1 NAGLU CCR10
GH17F042997 0.7 Ensembl ENCODE 10.3 +175.6 175564 5.2 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC DHX8 NBR2 ENSG00000267758 LINC00910 HMGN1P29 HMGN2P15 NAGLU ENSG00000267604 RPL27 FAM134C
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PSME3 on UCSC Golden Path with GeneCards custom track

Promoters for PSME3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001346692 -285 1401 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZNF143

Genomic Location for PSME3 Gene

Chromosome:
17
Start:
42,824,385 bp from pter
End:
42,843,760 bp from pter
Size:
19,376 bases
Orientation:
Plus strand

Genomic View for PSME3 Gene

Genes around PSME3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSME3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSME3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSME3 Gene

Proteins for PSME3 Gene

  • Protein details for PSME3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61289-PSME3_HUMAN
    Recommended name:
    Proteasome activator complex subunit 3
    Protein Accession:
    P61289
    Secondary Accessions:
    • A8K9A3
    • O35563
    • P97373
    • Q12920
    • Q13172
    • Q9BQD9

    Protein attributes for PSME3 Gene

    Size:
    254 amino acids
    Molecular mass:
    29506 Da
    Quaternary structure:
    • Homoheptamer; the stability of the heptamer is essential for the specific activation of the trypsine-like subunit and inhibition of the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits of the proteasome. Interacts with p53/TP53 and MDM2. Interacts with MAP3K3 (By similarity). Associates with the proteasome. Interacts with human cytomegalovirus UL27. Interacts with CCAR2.

    Alternative splice isoforms for PSME3 Gene

neXtProt entry for PSME3 Gene

Post-translational modifications for PSME3 Gene

  • Acetylation at the major site Lys-195 is important for oligomerization and ability to degrade its target substrates. Deacetylated by SIRT1.
  • Phosphorylated by MAP3K3 (By similarity). Phosphorylation at Ser-247 promotes its association with CCAR2.
  • Ubiquitination at Lys 14, Lys 37, Lys 100, Lys 110, Lys 121, and Lys 195
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSME3 (PSME3)
  • Cloud-Clone Corp. Antibodies for PSME3

No data available for DME Specific Peptides for PSME3 Gene

Domains & Families for PSME3 Gene

Gene Families for PSME3 Gene

Graphical View of Domain Structure for InterPro Entry

P61289

UniProtKB/Swiss-Prot:

PSME3_HUMAN :
  • The C-terminal sequences affect heptamer stability and proteasome affinity.
  • Belongs to the PA28 family.
Domain:
  • The C-terminal sequences affect heptamer stability and proteasome affinity.
Family:
  • Belongs to the PA28 family.
genes like me logo Genes that share domains with PSME3: view

Function for PSME3 Gene

Molecular function for PSME3 Gene

GENATLAS Biochemistry:
proteasome (prosome,macropain) activator subunit 3 (PA28-gamma)
UniProtKB/Swiss-Prot Function:
Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978).
UniProtKB/Swiss-Prot Induction:
Up-regulated in thyroid carcinoma cells.

Gene Ontology (GO) - Molecular Function for PSME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IDA 18309296
GO:0005515 protein binding IPI 12970408
GO:0042802 identical protein binding IPI 16169070
GO:0061133 endopeptidase activator activity IDA 18309296
GO:0097371 MDM2/MDM4 family protein binding IDA 18309296
genes like me logo Genes that share ontologies with PSME3: view
genes like me logo Genes that share phenotypes with PSME3: view

Animal Models for PSME3 Gene

MGI Knock Outs for PSME3:

Animal Model Products

miRNA for PSME3 Gene

miRTarBase miRNAs that target PSME3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSME3 Gene

Localization for PSME3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSME3 Gene

Nucleus. Cytoplasm. Note=Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSME3 Gene COMPARTMENTS Subcellular localization image for PSME3 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PSME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS 8811196
GO:0005634 nucleus IEA,IDA 21630459
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSME3: view

Pathways & Interactions for PSME3 Gene

SuperPathways for PSME3 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
.78
.32
2 RET signaling
3 HIV Life Cycle
.45
4 Class I MHC mediated antigen processing and presentation
5 Antigen processing-Cross presentation
genes like me logo Genes that share pathways with PSME3: view

Gene Ontology (GO) - Biological Process for PSME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006521 regulation of cellular amino acid metabolic process TAS --
genes like me logo Genes that share ontologies with PSME3: view

No data available for SIGNOR curated interactions for PSME3 Gene

Drugs & Compounds for PSME3 Gene

(5) Drugs for PSME3 Gene - From: ApexBio and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 794
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
AM 114 Pharma 20S proteasome inhibitor 0
CEP-18770 Pharma Proteasome inhibitor 0
MLN9708 Pharma Proteasome inhibitor, 20S Proteasome Inhibitor 0

(3) ApexBio Compounds for PSME3 Gene

Compound Action Cas Number
AM 114 20S proteasome inhibitor 856849-35-9
CEP-18770 Proteasome inhibitor 847499-27-8
MLN9708 Proteasome inhibitor 1201902-80-8
genes like me logo Genes that share compounds with PSME3: view

Transcripts for PSME3 Gene

Unigene Clusters for PSME3 Gene

Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSME3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - -
SP2: - - - -
SP3: -
SP4: -
SP5: - - -
SP6: - - - - - -
SP7: - - - -
SP8: -
SP9: - - - - - - -
SP10:
SP11:

Relevant External Links for PSME3 Gene

GeneLoc Exon Structure for
PSME3
ECgene alternative splicing isoforms for
PSME3

Expression for PSME3 Gene

mRNA expression in normal human tissues for PSME3 Gene

Protein differential expression in normal tissues from HIPED for PSME3 Gene

This gene is overexpressed in Bone (13.9) and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSME3 Gene



Protein tissue co-expression partners for PSME3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSME3 Gene:

PSME3

SOURCE GeneReport for Unigene cluster for PSME3 Gene:

Hs.152978
genes like me logo Genes that share expression patterns with PSME3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSME3 Gene

Orthologs for PSME3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PSME3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSME3 34 35
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia PSME3 34 35
  • 96.59 (n)
rat
(Rattus norvegicus)
Mammalia Psme3 34
  • 94.62 (n)
dog
(Canis familiaris)
Mammalia PSME3 34 35
  • 94.13 (n)
mouse
(Mus musculus)
Mammalia Psme3 34 16 35
  • 94.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PSME3 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSME3 34 35
  • 85.96 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 96 (a)
OneToMany
-- 35
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia psme3 34
  • 77.3 (n)
Str.3210 34
zebrafish
(Danio rerio)
Actinopterygii psme3 34 35
  • 73.62 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10191 34
fruit fly
(Drosophila melanogaster)
Insecta REG 36 34 35
  • 54.95 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000308 34
  • 54.43 (n)
worm
(Caenorhabditis elegans)
Secernentea Y66D12A.9 36 34 35
  • 53.22 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9143 35
  • 53 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.73 34
Species where no ortholog for PSME3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSME3 Gene

ENSEMBL:
Gene Tree for PSME3 (if available)
TreeFam:
Gene Tree for PSME3 (if available)

Paralogs for PSME3 Gene

Paralogs for PSME3 Gene

Pseudogenes.org Pseudogenes for PSME3 Gene

genes like me logo Genes that share paralogs with PSME3: view

Variants for PSME3 Gene

Sequence variations from dbSNP and Humsavar for PSME3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10542459 -- 42,841,928(+) TTTGA(-/TAAT)TAGTT nc-transcript-variant, utr-variant-3-prime
rs1056730 -- 42,843,060(+) ACCCT(C/G)CAGAT nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs111470609 -- 42,834,859(+) ATAGC(C/T)ATGAT nc-transcript-variant, reference, missense
rs111565009 -- 42,841,809(+) CCTGT(C/T)GTAAT nc-transcript-variant, utr-variant-3-prime
rs111608189 -- 42,836,386(+) TTGTT(A/C)ACTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSME3 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER inversion 15654335
nsv1146669 OTHER inversion 26484159
nsv483009 CNV gain 15286789

Variation tolerance for PSME3 Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 1.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSME3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSME3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSME3 Gene

Disorders for PSME3 Gene

Relevant External Links for PSME3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSME3

No disorders were found for PSME3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSME3 Gene

Publications for PSME3 Gene

  1. A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21. (PMID: 7951316) Albertsen H.M. … White R. (Nat. Genet. 1994) 2 3 4 64
  2. Cloning and nucleotide sequence of cDNA for Ki antigen, a highly conserved nuclear protein detected with sera from patients with systemic lupus erythematosus. (PMID: 1968796) Nikaido T. … Nishida Y. (Clin. Exp. Immunol. 1990) 3 4 22 64
  3. Chk2 and REGI^-dependent DBC1 regulation in DNA damage induced apoptosis. (PMID: 25361978) Magni M. … Zannini L. (Nucleic Acids Res. 2014) 3 4 64
  4. Site-specific acetylation of the proteasome activator REGI^ directs its heptameric structure and functions. (PMID: 23612972) Liu J. … Li X. (J. Biol. Chem. 2013) 3 4 64
  5. Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest. (PMID: 21320693) Reitsma J.M. … Terhune S.S. (Cell Host Microbe 2011) 3 4 64

Products for PSME3 Gene