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PSME3 Gene

protein-coding   GIFtS: 66
GCID: GC17P040985

Proteasome (Prosome, Macropain) Activator Subunit 3 (PA28...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proteasome (Prosome, Macropain) Activator Subunit 3 (PA28 Gamma;
Ki)1 2
     PA28-gamma2
Activator Of Multicatalytic Protease Subunit 32 3     REG-GAMMA2
Proteasome Activator 28 Subunit Gamma2 3     Epididymis Secretory Protein Li 2832
11S Regulator Complex Subunit Gamma2 3     Ki Antigen2
PA28gamma2 3     PA28 Gamma Variant 52
Ki Nuclear Autoantigen2 3     Proteasome Activator 28-Gamma2
PA28G2 5     Proteasome Activator Complex Subunit 32
11S Regulator Complex Gamma Subunit2     REG Gamma-32
HEL-S-2832     PA28g3
Ki2     REG-gamma3

External Ids:    HGNC: 95701   Entrez Gene: 101972   Ensembl: ENSG000001314677   OMIM: 6051295   UniProtKB: P612893   

Export aliases for PSME3 gene to outside databases

Previous GC identifers: GC17M040635 GC17P043138 GC17P040885 GC17P041358 GC17P038238 GC17P036749


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PSME3 Gene:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes,
a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are
composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a
base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in
an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome,
the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate
regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta
and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator.
Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript
variants. (provided by RefSeq, May 2012)

GeneCards Summary for PSME3 Gene:
PSME3 (proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)) is a protein-coding gene. GO annotations related to this gene include MDM2/MDM4 family protein binding and p53 binding. An important paralog of this gene is PSME2.

UniProtKB/Swiss-Prot: PSME3_HUMAN, P61289
Function: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped
homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of
the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the
MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53,
limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell
cycle regulation

Gene Wiki entry for PSME3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PSME3 gene promoter:
         GR   p53   AP-1   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PSME3 promoter sequence
   Search Chromatin IP Primers for PSME3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSME3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q12-q21

PSME3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSME3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P040985:  view genomic region     (about GC identifiers)

Start:
40,976,402 bp from pter      End:
40,995,777 bp from pter
Size:
19,376 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PSME3_HUMAN, P61289 (See protein sequence)
Recommended Name: Proteasome activator complex subunit 3  
Size: 254 amino acids; 29506 Da
Subunit: Homoheptamer; the stability of the heptamer is essential for the specific activation of the trypsine-like
subunit and inhibition of the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits of the proteasome.
Interacts with p53/TP53 and MDM2. Interacts with MAP3K3 (By similarity). Associates with the proteasome
Secondary accessions: A8K9A3 O35563 P97373 Q12920 Q13172 Q9BQD9
Alternative splicing: 2 isoforms:  P61289-1, Q12920-1   P61289-2, Q12920-2   

Explore the universe of human proteins at neXtProt for PSME3: NX_P61289

Explore proteomics data for PSME3 at MOPED

Post-translational modifications: 

  • Phosphorylated by MAP3K3 (By similarity)1
  • Acetylation at the major site Lys-195 is important for oligomerization and ability to degrade its target
    substrates. Deacetylated by SIRT11
  • Ubiquitination2 at Lys6, Lys14, Lys37, Lys100, Lys110, Lys121, Lys195
  • Modification sites at PhosphoSitePlus

  • See PSME3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001253974.1  NP_005780.2  NP_789839.1  

    ENSEMBL proteins: 
     ENSP00000441682   ENSP00000467580   ENSP00000466794   ENSP00000466451   ENSP00000409487  
     ENSP00000465743   ENSP00000466945   ENSP00000437924   ENSP00000293362   ENSP00000468702  
     ENSP00000465155   ENSP00000438237  
    Reactome Protein details: P61289

    PSME3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for PSME3 (PA28 Activator gamma Subunit)
    Enzo Life Sciences proteins for PSME3
    OriGene Purified Protein for PSME3
    OriGene Protein Over-expression Lysate for PSME3
    OriGene MassSpec for PSME3
    OriGene Custom Protein Services for PSME3
    GenScript Custom Purified and Recombinant Proteins Services for PSME3
    Novus Biologicals PSME3 Proteins
    Novus Biologicals PSME3 Lysates
    Sino Biological Recombinant Protein for PSME3
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PSME3
    Cloud-Clone Corp. Proteins for PSME3

     
    Search eBioscience for Proteins for PSME3 

     
    antibodies-online proteins for PSME3 (9 products) 

     
    antibodies-online peptides for PSME3

    PSME3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for PSME3 
    OriGene Antibodies for PSME3
    OriGene Custom Antibody Services for PSME3
    Novus Biologicals PSME3 Antibodies
    Abcam antibodies for PSME3
    Cloud-Clone Corp. Antibodies for PSME3
    ThermoFisher Antibody for PSME3
    antibodies-online antibodies for PSME3 (47 products) 

    PSME3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PSME3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PSME3
    Cloud-Clone Corp. CLIAs for PSME3
    Search eBioscience for ELISAs for PSME3 
    antibodies-online kits for PSME3 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PSM: Proteasome (prosome, macropain) subunits

    3 InterPro protein domains:
     IPR003186 Proteasome_activ_pa28_C
     IPR003185 Proteasome_activ_pa28_N
     IPR009077 Proteasome_activ_pa28

    Graphical View of Domain Structure for InterPro Entry P61289

    ProtoNet protein and cluster: P61289

    1 Blocks protein domain: IPB003185 Proteasome activator pa28

    UniProtKB/Swiss-Prot: PSME3_HUMAN, P61289
    Domain: The C-terminal sequences affect heptamer stability and proteasome affinity
    Similarity: Belongs to the PA28 family


    Find genes that share domains with PSME3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PSME3_HUMAN, P61289
    Function: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped
    homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of
    the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the
    MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53,
    limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell
    cycle regulation
    Induction: Up-regulated in thyroid carcinoma cells

         Genatlas biochemistry entry for PSME3:
    proteasome (prosome,macropain) activator subunit 3 (PA28-gamma)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IDA18309296
    GO:0005515protein binding IPI16439211
    GO:0061133endopeptidase activator activity IDA18309296
    GO:0097371MDM2/MDM4 family protein binding IDA18309296
         
    Find genes that share ontologies with PSME3           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Psme3):
     cellular  growth/size/body  hematopoietic system  immune system 

    Find genes that share phenotypes with PSME3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PSME3: Psme3tm1Tchi Psme3tm1Jjm

       genOway: Develop your customized and physiologically relevant rodent model for PSME3

    miRNA
    Products:
        
    miRTarBase miRNAs that target PSME3:
    hsa-mir-484 (MIRT042151), hsa-mir-331-3p (MIRT043475), hsa-mir-124-3p (MIRT022991), hsa-mir-155-5p (MIRT020956), hsa-mir-324-5p (MIRT043211), hsa-let-7b-5p (MIRT032477), hsa-mir-24-3p (MIRT030577), hsa-mir-7-5p (MIRT004063), hsa-mir-16-5p (MIRT031898)

    Block miRNA regulation of human, mouse, rat PSME3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PSME3 (see all 58):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-549 hsa-miR-328 hsa-miR-379* hsa-miR-548k hsa-miR-15a hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidPSME3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PSME3
    Predesigned siRNA for gene silencing in human, mouse, rat PSME3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PSME3

    Clone
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    OriGene clones in human, mouse for PSME3 (see all 12)
    OriGene ORF clones in mouse, rat for PSME3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PSME3 (NM_176863)
    Sino Biological Human cDNA Clone for PSME3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSME3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSME3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PSME3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSME3

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12087) for PSME3 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PSME3_HUMAN, P61289: Nucleus. Cytoplasm (By similarity). Note=Localizes to the cytoplasm during mitosis following
    nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3
    kinase (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex TAS8811196
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with PSME3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PSME3 About   (see all 16)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    CDK-mediated phosphorylation and removal of Cdc60.94
    Destabilization of mRNA by AUF1 (hnRNP D0)0.88
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    G1/S DNA Damage Checkpoints0.87
    Ubiquitin-dependent degradation of Cyclin D10.94
    CDT1 association with the CDC6-ORC-origin complex0.87
    Ubiquitin-dependent degradation of Cyclin D0.94
    SCF(Skp2)-mediated degradation of p27/p210.86
    2Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    4Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    5E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    G1/S Transition0.81


    Find genes that share SuperPaths with PSME3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PSME3
        Protein Stability

    1 GeneGo (Thomson Reuters) Pathway for PSME3
        Immune response Antigen presentation by MHC class I

    1 BioSystems Pathway for PSME3
        Proteasome Degradation


    Selected Reactome Pathways for PSME3 (see all 24)
        SCF(Skp2)-mediated degradation of p27/p21
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
    SCF-beta-TrCP mediated degradation of Emi1
    Ubiquitin-dependent degradation of Cyclin D1
    Orc1 removal from chromatin


    3 Kegg Pathways  (Kegg details for PSME3):
        Proteasome
    Antigen processing and presentation
    Hepatitis C

        Pathway & Disease-focused RT2 Profiler PCR Array including PSME3: 
              Hepatotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PSME3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PSME3 (P612891, 2, 3 ENSP000002933624) via UniProtKB, MINT, STRING, and/or I2D (see all 190)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009871, 2, 3, ENSP000004172814EBI-355546,EBI-389668 MINT-6540807 MINT-6540920 MINT-6540776 MINT-6540837 MINT-6540985 MINT-6540853 MINT-6540796 MINT-6540973 MINT-6540998 I2D: score=3 STRING: ENSP00000417281
    TP53P046371, 2, 3, ENSP000002693054EBI-355546,EBI-366083 MINT-6540807 MINT-6540940 MINT-6540866 MINT-6540920 MINT-6540876 MINT-6540776 MINT-6541016 MINT-6540960 MINT-6540796 I2D: score=3 STRING: ENSP00000269305
    SMURF1Q9HCE71, 2, 3, ENSP000003546214EBI-355546,EBI-976466 MINT-7894494 MINT-7894481 MINT-7894523 MINT-7894558 MINT-7894543 I2D: score=2 STRING: ENSP00000354621
    COILP384321, 2, 3, ENSP000002403164EBI-355546,EBI-945751 MINT-2868141 MINT-2868160 I2D: score=3 STRING: ENSP00000240316
    ATP5BP065762, 3, ENSP000002620304MINT-63935 I2D: score=5 STRING: ENSP00000262030
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--

    Find genes that share ontologies with PSME3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PSME3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PSME3 gene (3 alternative transcripts): 
    NM_001267045.1  NM_005789.3  NM_176863.2  

    Unigene Cluster for PSME3:

    Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
    Hs.152978  [show with all ESTs]
    Unigene Representative Sequence: NM_001267045
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592458 ENST00000545225(uc002ibp.3) ENST00000586114 ENST00000590720
    ENST00000585805 ENST00000592578 ENST00000441946(uc002ibr.3 uc002ibs.3 uc010whd.2)
    ENST00000591152 ENST00000589469 ENST00000591722 ENST00000543428 ENST00000293362(uc002ibq.3)
    ENST00000592169 ENST00000586312 ENST00000593111 ENST00000541124
    miRNA
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    Block miRNA regulation of human, mouse, rat PSME3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PSME3 (see all 58):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-549 hsa-miR-328 hsa-miR-379* hsa-miR-548k hsa-miR-15a hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidPSME3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PSME3
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PSME3 (NM_176863)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSME3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSME3
    Primer
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    OriGene qPCR primer pairs and template standards for PSME3
    OriGene qSTAR qPCR primer pairs in human, mouse for PSME3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PSME3
      QuantiTect SYBR Green Assays in human, mouse, rat PSME3
      QuantiFast Probe-based Assays in human, mouse, rat PSME3
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12087) for PSME3 

    Additional mRNA sequence: 

    AK057221.1 AK074999.1 AK292618.1 AK303211.1 AK307110.1 AK314347.1 BC001423.2 BC002684.1 
    BC008020.1 BT019386.1 CR541745.1 FJ200488.1 JX156303.1 NR_049772.1 U11292.1 

    24 DOTS entries:

    DT.100877015  DT.100877011  DT.456118  DT.100877010  DT.95107611  DT.95169537  DT.100801837  DT.99955026 
    DT.100877022  DT.121006646  DT.100877014  DT.100877016  DT.121006638  DT.121006679  DT.91777635  DT.101977223 
    DT.102828673  DT.121006641  DT.121006747  DT.121006748  DT.99928402  DT.100877009  DT.121006693  DT.91777652 

    Selected AceView cDNA sequences (see all 626):

    BM672227 BE748865 BC002684 BM835823 BC001423 BQ688349 AL135611 CA975885 
    CA416183 BM716695 AW848602 BM992335 BM975036 AA887631 AU280332 BU154778 
    BM983497 BE269650 BQ684681 AW376711 AA903540 AA903713 AA915876 AA381850 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PSME3 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
    SP1:                                                  -                 -                                                         
    SP2:                                                  -     -     -     -                                                         
    SP3:                                                  -                                                                           
    SP4:                                                  -                                                                           
    SP5:                                                  -                 -     -                                                   


    ECgene alternative splicing isoforms for PSME3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PSME3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAGAAATT
    PSME3 Expression
    About this image


    PSME3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    PSME3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PSME3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.152978
        Pathway & Disease-focused RT2 Profiler PCR Array including PSME3: 
              Hepatotoxicity in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PSME3 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Psme31 , 5 proteaseome (prosome, macropain) 28 subunit, 35
    proteaseome (prosome, macropain) activator subunit more1
    94.09(n)1
    100(a)1
      11 (64.67 cM)5
    191921  NM_011192.31  NP_035322.11 
     1013162135 
    chicken
    (Gallus gallus)
    Aves PSME31 proteasome (prosome, macropain) activator subunit 3 more 85.96(n)
    96.46(a)
      420017  NM_001012550.2  NP_001012568.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    96(a)
    72(a)
    1 ↔ many
    1 ↔ many
    6(62293798-62314400)
    2(154785916-154786665)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ737418.12   -- 77.22(n)    BQ737418.1 
    zebrafish
    (Danio rerio)
    Actinopterygii psme32 proteasome activator subunit 3 75.51(n)   30649  BC045495.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta REG1 , 3 REG1 46(a)3
    54.95(n)1
    49.37(a)1
      11E33
    322741  NM_132638.31  NP_572866.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y66D12A.91 , 3 Y66D12A.91 48(a)3
    53.22(n)1
    52.36(a)1
      III(11639787-11644820)3
    1765881  NM_067092.41  NP_499493.11 


    ENSEMBL Gene Tree for PSME3 (if available)
    TreeFam Gene Tree for PSME3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PSME3 gene
    PSME22  PSME12  
    2 SIMAP similar genes for PSME3 using alignment to 10 protein entries:     PSME3_HUMAN (see all proteins):
    PSME1    PSME2

    Find genes that share paralogs with PSME3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PSME3
    PGOHUM00000245048


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PSME3 (see all 252)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs5936481,2
    C,F,H--40983207(-) ACTTAA/CCAATA 4 -- us2k110Minor allele frequency- C:0.01NS EA NA CSA WA 922
    rs1871140081,2
    --40983305(+) AAGAGA/TATGTG 4 -- us2k10--------
    rs799236101,2
    C,F--40983327(+) TAACCT/CACTTG 4 -- us2k11Minor allele frequency- C:0.09WA 118
    rs1457522851,2
    C--40983397(+) AGCTTG/TTCCAG 4 -- us2k10--------
    rs1929561431,2
    --40983411(+) ATGTTA/GTAAAT 4 -- us2k10--------
    rs1846161591,2
    --40983750(+) TTATTC/TCTAAT 4 -- us2k10--------
    rs1902805631,2
    --40983751(+) TATTTC/GTAATA 4 -- us2k10--------
    rs37602081,2
    C,F,A,H--40983813(+) TCCATC/TTTACA 4 -- us2k118Minor allele frequency- T:0.21NS EA NA WA CSA 1894
    rs1814766381,2
    --40983869(+) CCAGTC/TAGTAA 4 -- us2k10--------
    rs1850952981,2
    --40984021(+) AGCAAC/GAGCGA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for PSME3 (40976402 - 40995777 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PSME3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv483009CNV Gain15286789
    esv33998OTHER Inversion15654335

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PSME3
    DNA2.0 Custom Variant and Variant Library Synthesis for PSME3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605129    OMIM disorders: --


    Find genes that share disorders with PSME3           About GenesLikeMe

    1 Novoseek inferred disease relationship for PSME3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lupus erythematosus systemic 45.8 2 1968796 (2)


    Export disorders for PSME3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PSME3 gene, integrated from 10 sources (see all 135):
    (articles sorted by number of sources associating them with PSME3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21. (PubMed id 7951316)1, 2, 3 Albertsen H.M....White R. (Nat. Genet. 1994)
    2. Cloning and nucleotide sequence of cDNA for Ki antigen, a highly conserved nuclear protein detected with sera from patients with systemic lupus erythematosus. (PubMed id 1968796)1, 2, 9 Nikaido T.... Nishida Y. (Clin. Exp. Immunol. 1990)
    3. Site-specific acetylation of the proteasome activator REGI^ directs its heptameric structure and functions. (PubMed id 23612972)1, 2 Liu J....Li X. (J. Biol. Chem. 2013)
    4. Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2- mediated degradation. (PubMed id 18309296)1, 2 Zhang Z. and Zhang R. (EMBO J. 2008)
    5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. (PubMed id 7545954)1, 2 Miki Y.... Skolnick M.H. (Science 1994)
    9. REGgamma proteasome activator is involved in the maintenance of chromosomal stability. (PubMed id 18235248)1, 9 Zannini L....Delia D. (Cell Cycle 2008)
    10. Properties of the nuclear proteasome activator PA28gamma (REGgamma). (PubMed id 11185562)2, 9 Wilk S.... Magnusson R.P. (Arch. Biochem. Biophys. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10197 HGNC: 9570 AceView: PSME3 Ensembl:ENSG00000131467 euGenes: HUgn10197
    ECgene: PSME3 Kegg: 10197 H-InvDB: PSME3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PSME3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PSME3 gene:
    Search GeneIP for patents involving PSME3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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