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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PSME3 Gene

protein-coding   GIFtS: 65
GCID: GC17P040985

proteasome (prosome, macropain) activator subunit 3 (PA28...
 Explore 23 diseases affiliated with
PSME3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PSME3    

Aliases
for PSME3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Proteasome (Prosome, Macropain) Activator Subunit 3 (PA28 Gamma; Ki)1 2     Ki Nuclear Autoantigen2 3
PA28G1 2 5     11S Regulator Complex Gamma Subunit2
Ki1 2     Ki Antigen2
PA28-Gamma1     PA28 Gamma Variant 52
REG-GAMMA1 2     Proteasome Activator 28-Gamma2
Activator Of Multicatalytic Protease Subunit 32 3     Proteasome Activator Complex Subunit 32
Proteasome Activator 28 Subunit Gamma2 3     PA28g3
11S Regulator Complex Subunit Gamma2 3     REG-Gamma1
PA28gamma2 3     

External Ids:    HGNC: 95701   Entrez Gene: 101972   Ensembl: ENSG000001314677   OMIM: 6051295   UniProtKB: P612893   

Export aliases for PSME3 gene to outside databases

Previous GC identifers: GC17M040635 GC17P043138 GC17P040885 GC17P041358 GC17P038238 GC17P036749


Summaries
for PSME3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PSME3:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a
20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed
of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which
contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits.
Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an
ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the
immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator,
referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of
the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits
combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants. (provided by RefSeq,
May 2012)

UniProtKB/Swiss-Prot: PSME3_HUMAN, P61289
Function: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer
which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but
inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction
which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and
resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation

Gene Wiki entry for PSME3


Genomic Views
for PSME3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PSME3 gene promoter:
         GR   p53   AP-1   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PSME3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PSME3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSME3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q12-q21

PSME3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSME3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P040985:  view genomic region     (about GC identifiers)

Start:
 40,976,402 bp from pter      End:
 40,995,777 bp from pter
Size:
 19,376 bases      Orientation:
 plus strand

Proteins
for PSME3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PSME3_HUMAN, P61289 (See protein sequence)
Recommended Name: Proteasome activator complex subunit 3  
Size: 254 amino acids; 29506 Da
Subunit: Homoheptamer; the stability of the heptamer is essential for the specific activation of the trypsine-like
subunit and inhibition of the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits of the proteasome.
Interacts with p53/TP53 and MDM2. Interacts with MAP3K3 (By similarity). Associates with the proteasome
Subcellular location: Nucleus. Cytoplasm (By similarity). Note=Localizes to the cytoplasm during mitosis following
nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase
(By similarity)
Secondary accessions: A8K9A3 O35563 P97373 Q12920 Q13172 Q9BQD9
Alternative splicing: 2 isoforms:  P61289-1, Q12920-1   P61289-2, Q12920-2   

Explore the universe of human proteins at neXtProt for PSME3: NX_P61289

Post-translational modifications:

  • Phosphorylated by MAP3K3 (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P61289

    • PSME3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001253974.1  NP_005780.2  NP_789839.1  

    ENSEMBL proteins: 
     ENSP00000441682   ENSP00000467580   ENSP00000466794   ENSP00000466451   ENSP00000409487  
     ENSP00000465743   ENSP00000466945   ENSP00000437924   ENSP00000293362   ENSP00000468702  
     ENSP00000465155   ENSP00000438237  
    Reactome Protein details: P61289
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for PSME3 (PA28 Activator gamma Subunit)
    Enzo Life Sciences proteins for PSME3
    OriGene Purified Protein: PSME3
    OriGene Protein Over-expression Lysate (see all 2): PSME3
    OriGene Custom Protein Services for PSME3 
    GenScript Custom Purified and Recombinant Proteins Services for PSME3
    Novus Biologicals PSME3 Proteins
    Novus Biologicals PSME3 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for PSME3
    Uscn Proteins for PSME3

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex TAS8811196
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0008537proteasome activator complex IEA--


    PSME3 for ontologies           About GeneDecksing



    PSME3 Antibody Products: 
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    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for PSME3 
    OriGene Antibodies (see all 2): PSME3
    OriGene Custom Antibody Services for PSME3 
    GenScript Custom Superior Antibodies Services for PSME3
    Novus Biologicals PSME3 Antibodies
    Abcam antibodies for PSME3 
    Uscn Antibodies for PSME3
    ThermoFisher Antibody for PSME3

    Assay Products for PSME3: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PSME3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PSME3

    Protein Domains /
    Families
    for PSME3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PSME3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR003186 Proteasome_activ_REG_bsu
     IPR003185 Proteasome_activ_REG_asu
     IPR009077 Proteasome_activ_REG_asu/bsu

    Graphical View of Domain Structure for InterPro Entry P61289

    ProtoNet protein and cluster: P61289

    1 Blocks protein family: IPB003185 Proteasome activator pa28

    UniProtKB/Swiss-Prot: PSME3_HUMAN, P61289
    Domain: The C-terminal sequences affect heptamer stability and proteasome affinity
    Similarity: Belongs to the PA28 family


    Function
    for PSME3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PSME3_HUMAN, P61289
    Function: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer
    which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but
    inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction
    which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and
    resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation
    Induction: Up-regulated in thyroid carcinoma cells

         Genatlas biochemistry entry for PSME3:
    proteasome (prosome,macropain) activator subunit 3 (PA28-gamma)

    miRNA
    Products:            		miRTarBase miRNAs that target PSME3:
    hsa-mir-7 (MIRT004063)

    OriGene 3'-UTR Clone (see all 2): PSME3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSME3
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate PSME3 (see all 58):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-549 hsa-miR-328 hsa-miR-379* hsa-miR-548k hsa-miR-15a hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmid: PSME3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSME3 (see all 7)
    OriGene shRNA RFP: PSME3
    OriGene siRNA: PSME3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSME3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PSME3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSME3 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSME3 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): PSME3 (NM_176863)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSME3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSME3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PSME3
    Search LifeMap BioReagents cell lines for PSME3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSME3

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IDA18309296
    GO:0005515protein binding IPI--
    GO:0061133endopeptidase activator activity IDA18309296
    GO:0070215MDM2 binding ----
    GO:0097371MDM2/MDM4 family protein binding IDA18309296


    PSME3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for PSME3: Psme3tm1Tchi Psme3tm1Jjm
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Psme3):
     cellular  growth/size  hematopoietic system  immune system 

    PSME3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PSME3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitinated Orc1 is degraded by the proteasome
    8/76 pathways (see all 76)
    		Ubiquitinated Orc1 is degraded by the proteasome1.00
    		Assembly of the pre-replicative complex0.77
    		Proteasomal cleavage of substrate0.98
    		Degradation of ubiquitinated p27/p21 by the 26S proteasome0.75
    		Proteasome mediated degradation of PAK-2p340.98
    		SCF(Skp2)-mediated degradation of p27/p210.75
    		Proteasomal cleavage of substrate0.98
    		APC/C:Cdh1-mediated degradation of Skp20.74
    2M Phase
    		M Phase1.00
    		Mitotic Anaphase0.85
    		Mitotic M-M/G1 phases0.88
    		Separation of Sister Chromatids0.80
    		Mitotic Metaphase and Anaphase0.85
    3Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Class I MHC mediated antigen processing & presentation0.83
    4Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    5HIV Infection
    		HIV Infection1.00
    		Host Interactions of HIV factors0.64

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for PSME3
        Immune response Antigen presentation by MHC class I


    1 Cell Signaling Technology (CST) Pathway for PSME3
        Protein Stability

    1 GeneGo (Thomson Reuters) Pathway for PSME3
        Immune response Antigen presentation by MHC class I

    1 BioSystems Pathway for PSME3 
        Proteasome Degradation

    5/98        Reactome Pathways for PSME3 (see all 98)
        Ubiquitinated geminin is degraded by the proteasome
    Proteolytic degradation of ubiquitinated-Cdc25A
    Orc1 removal from chromatin
    CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway


    3         Kegg Pathways  (Kegg details for PSME3):
        Proteasome
    Antigen processing and presentation
    Hepatitis C


    PSME3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PSME3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/184 Interacting proteins for PSME3 (P612891, 2, 3 ENSP000002933624) via UniProtKB, MINT, STRING, and/or I2D (see all 184)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009872, 3, ENSP000004172814MINT-6540807 MINT-6540920 MINT-6540776 MINT-6540837 MINT-6540985 MINT-6540853 MINT-6540796 MINT-6540998 MINT-6540973 I2D: score=3 STRING: ENSP00000417281
    TP53P046372, 3, ENSP000002693054MINT-6540807 MINT-6540940 MINT-6540866 MINT-6540920 MINT-6540876 MINT-6540776 MINT-6541016 MINT-6540960 MINT-6540796 I2D: score=3 STRING: ENSP00000269305
    ATN1P542591, 2, 3, ENSP000003490764EBI-355546,EBI-945980 MINT-2868084 MINT-2868122 MINT-2868103 I2D: score=3 STRING: ENSP00000349076
    SMURF1Q9HCE72, 3, ENSP000003546214MINT-7894494 MINT-7894481 MINT-7894523 MINT-7894558 MINT-7894543 I2D: score=2 STRING: ENSP00000354621
    ADAP1O756892, 3, ENSP000002658464MINT-63934 I2D: score=5 STRING: ENSP00000265846
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000084S phase of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000216M/G1 transition of mitotic cell cycle TAS--


    PSME3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PSME3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PSME3
    Search CenterWatch for drugs/clinical trials and news about PSME3 

    Transcripts
    for PSME3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PSME3 gene (3 alternative transcripts): 
    NM_001267045.1  NM_005789.3  NM_176863.2  

    Unigene Cluster for PSME3:

    Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
    Hs.152978  [show with all ESTs]
    Unigene Representative Sequence: NM_001267045
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592458 ENST00000545225(uc002ibp.3) ENST00000586114 ENST00000590720
    ENST00000585805 ENST00000592578 ENST00000441946(uc002ibr.3 uc002ibs.3 uc010whd.2)
    ENST00000591152 ENST00000589469 ENST00000591722 ENST00000543428 ENST00000293362(uc002ibq.3)
    ENST00000592169 ENST00000586312 ENST00000593111 ENST00000541124

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): PSME3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSME3
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate PSME3 (see all 58):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-549 hsa-miR-328 hsa-miR-379* hsa-miR-548k hsa-miR-15a hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmid: PSME3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSME3 (see all 7)
    OriGene shRNA RFP: PSME3
    OriGene siRNA: PSME3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSME3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSME3 (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): PSME3 (NM_176863)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSME3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSME3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PSME3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSME3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSME3

    Additional cDNA sequence: 

    AK057221.1 AK074999.1 AK292618.1 AK303211.1 AK307110.1 AK314347.1 BC001423.2 BC002684.1 
    BC008020.1 BT019386.1 CR541745.1 JX156303.1 NR_049772.1 U11292.1 

    24 DOTS entries:

    DT.100877015  DT.100877011  DT.456118  DT.100877010  DT.95107611  DT.95169537  DT.100801837  DT.99955026 
    DT.100877022  DT.121006646  DT.100877014  DT.100877016  DT.121006638  DT.121006679  DT.91777635  DT.101977223 
    DT.102828673  DT.121006641  DT.121006747  DT.121006748  DT.99928402  DT.100877009  DT.121006693  DT.91777652 

    24/626 AceView cDNA sequences (see all 626):

    NM_176863 BE268018 AW193110 R50092 BQ670072 BU190366 CR610201 BU520860 
    BX475793 AA947579 AU124713 BX490383 AK074999 BF512123 BC008020 BQ894141 
    BM463127 BF794624 AI817994 BM984615 BM837995 AI262516 BM126927 BG482487 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for PSME3 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
    SP1:                                                  -                 -                                                         
    SP2:                                                  -     -     -     -                                                         
    SP3:                                                  -                                                                           
    SP4:                                                  -                                                                           
    SP5:                                                  -                 -     -                                                   


    ECgene alternative splicing isoforms for PSME3

    Expression
    for PSME3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PSME3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCAAGAAATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See PSME3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PSME3

    SOURCE GeneReport for Unigene cluster: Hs.152978
        SABiosciences Expression via Pathway-Focused PCR Array including PSME3: 
              Hepatotoxicity in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSME3
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    In Situ
    Assay Products:     
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    Orthologs
    for PSME3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PSME3 gene from 6/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PSME31 proteasome (prosome, macropain) activator subunit 3 more 85.96(n)
    96.46(a)    		   420017  NM_001012550.1  NP_001012568.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 91(a)
    71(a)
    		 1 ↔ many
    1 ↔ many
    		 6(62302634-62314400)
    2(154785916-154786665)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BQ737418.12   -- 77.22(n)    BQ737418.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii psme32 proteasome activator subunit 3 75.51(n)   30649  BC045495.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta REG1 , 3 CG1591-PA1 46(a)3
    54.95(n)1
    49.37(a)1    		   11E33
    322741  NM_132638.21  NP_572866.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y66D12A.91 , 3 Protein Y66D12A.91 48(a)3
    53.22(n)1
    52.36(a)1    		   III(11639787-11644820)3
    1765881  NM_067092.31  NP_499493.11 


    ENSEMBL Gene Tree for PSME3 (if available)
    TreeFam Gene Tree for PSME3 (if available) 

    Paralogs
    for PSME3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PSME3 gene
    PSME22  PSME12  
    2 SIMAP similar genes for PSME3 using alignment to 10 protein entries:     PSME3_HUMAN (see all proteins):
    PSME1    PSME2

    PSME3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PSME3
    PGOHUM00000245048


    Genomic Variants
    for PSME3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/182 NCBI SNPs in PSME3 are shown (see all 182)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs5936481,2
    		C,F,H,--40983207(-) ACTTAA/CCAATA 4 -- us2k110Minor allele frequency- C:0.01NS EA NA CSA WA 922
    rs1871140081,2
    		--40983305(+) AAGAGA/TATGTG 4 -- us2k10--------
    rs799236101,2
    		F,--40983327(+) TAACCT/CACTTG 4 -- us2k11Minor allele frequency- C:0.09WA 118
    rs1457522851,2
    		--40983397(+) AGCTTG/TTCCAG 4 -- us2k10--------
    rs1929561431,2
    		--40983411(+) ATGTTA/GTAAAT 4 -- us2k10--------
    rs1846161591,2
    		--40983750(+) TTATTC/TCTAAT 4 -- us2k10--------
    rs1902805631,2
    		--40983751(+) TATTTC/GTAATA 4 -- us2k10--------
    rs37602081,2
    		C,F,A,H,--40983813(+) TCCATC/TTTACA 4 -- us2k118Minor allele frequency- T:0.21NS EA NA WA CSA 1894
    rs1814766381,2
    		--40983869(+) CCAGTC/TAGTAA 4 -- us2k10--------
    rs1850952981,2
    		--40984021(+) AGCAAC/GAGCGA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for PSME3 (40976402 - 40995777 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PSME3
         1 CNV: 0206

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    Disorders / Diseases
    for PSME3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PSME3 for disorders           About GeneDecksing

    OMIM gene information: 605129    OMIM disorders: --

    20/23 diseases for PSME3 (see all 23):    About MalaCards
    connective tissue disease    lupus erythematosus    b-cell lymphomas    systemic lupus erythematosus
    ataxia telangiectasia    breast-ovarian cancer    ovarian cancer    gallbladder carcinoma
    ptosis    hepatitis c    huntington's disease    ataxia
    thyroid carcinoma    meningioma    colorectal cancer    thyroiditis
    breast cancer    hepatitis    carcinoma    schizophrenia

    1 Novoseek disease relationship for PSME3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lupus erythematosus systemic 45.8 2 1968796 (2)


    Export disorders for PSME3 gene to outside databases

    Publications
    for PSME3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PSME3 gene, integrated from 9 sources (see all 120):
    (articles sorted by number of sources associating them with PSME3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21. (PubMed id 7951316)1, 2, 3 Albertsen H.M....White R. (1994)
    2. Cloning and nucleotide sequence of cDNA for Ki antigen, a highly conserved nuclear protein detected with sera from patients with systemic lupus erythematosus. (PubMed id 1968796)1, 2, 9 Nikaido T.... Nishida Y. (1990)
    3. Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2- mediated degradation. (PubMed id 18309296)1, 2 Zhang Z. and Zhang R. (2008)
    4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. (PubMed id 7545954)1, 2 Miki Y.... Skolnick M.H. (1994)
    8. REGgamma proteasome activator is involved in the maintenance of chromosomal stability. (PubMed id 18235248)1, 9 Zannini L....Delia D. (2008)
    9. Properties of the nuclear proteasome activator PA28gamma (REGgamma). (PubMed id 11185562)2, 9 Wilk S.... Magnusson R.P. (2000)
    10. The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome. (PubMed id 16439211)1, 9 Li X....O'Malley B.W. (2006)

    External Searches for PSME3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PSME3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10197 HGNC: 9570 AceView: PSME3 Ensembl:ENSG00000131467 euGenes: HUgn10197
    ECgene: PSME3 Kegg: 10197 H-InvDB: PSME3

    Other Databases showing PSME3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PSME3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PSME3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PSME3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PSME3 gene:
    Search GeneIP for patents involving PSME3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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