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Aliases for PSME2 Gene

Aliases for PSME2 Gene

  • Proteasome Activator Subunit 2 2 3 5
  • Proteasome (Prosome, Macropain) Activator Subunit 2 (PA28 Beta) 2 3
  • Activator Of Multicatalytic Protease Subunit 2 3 4
  • Proteasome Activator 28 Subunit Beta 3 4
  • 11S Regulator Complex Subunit Beta 3 4
  • PA28beta 3 4
  • REG-Beta 3 4
  • PA28B 3 4
  • Proteasome Activator HPA28 Subunit Beta 3
  • 11S Regulator Complex Beta Subunit 3
  • Cell Migration-Inducing Protein 22 3
  • MCP Activator, 31-KD Subunit 3
  • Proteasome Activator 28-Beta 3
  • REGbeta 3

External Ids for PSME2 Gene

Previous GeneCards Identifiers for PSME2 Gene

  • GC14M021985
  • GC14M018399
  • GC14M022602
  • GC14M023677
  • GC14M024612
  • GC14M004727

Summaries for PSME2 Gene

Entrez Gene Summary for PSME2 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSME2 Gene

PSME2 (Proteasome Activator Subunit 2) is a Protein Coding gene. Diseases associated with PSME2 include ulceroglandular tularemia. Among its related pathways are Gene Expression and Signaling by GPCR. An important paralog of this gene is PSME3.

UniProtKB/Swiss-Prot for PSME2 Gene

  • Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

Gene Wiki entry for PSME2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSME2 Gene

Genomics for PSME2 Gene

Regulatory Elements for PSME2 Gene

Promoters for PSME2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSME2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PSME2 gene promoter:

Genomic Location for PSME2 Gene

Chromosome:
14
Start:
24,143,362 bp from pter
End:
24,147,570 bp from pter
Size:
4,209 bases
Orientation:
Minus strand

Genomic View for PSME2 Gene

Genes around PSME2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSME2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSME2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSME2 Gene

Proteins for PSME2 Gene

  • Protein details for PSME2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL46-PSME2_HUMAN
    Recommended name:
    Proteasome activator complex subunit 2
    Protein Accession:
    Q9UL46
    Secondary Accessions:
    • Q15129

    Protein attributes for PSME2 Gene

    Size:
    239 amino acids
    Molecular mass:
    27402 Da
    Quaternary structure:
    • Heterodimer of PSME1 and PSME2, which forms a hexameric ring.

neXtProt entry for PSME2 Gene

Proteomics data for PSME2 Gene at MOPED

Post-translational modifications for PSME2 Gene

  • Ubiquitination at Lys 15, Lys 39, and Lys 145
  • Modification sites at PhosphoSitePlus

Other Protein References for PSME2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSME2 (PSME2)

No data available for DME Specific Peptides for PSME2 Gene

Domains & Families for PSME2 Gene

Gene Families for PSME2 Gene

Suggested Antigen Peptide Sequences for PSME2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UL46

UniProtKB/Swiss-Prot:

PSME2_HUMAN :
  • Belongs to the PA28 family.
Family:
  • Belongs to the PA28 family.
genes like me logo Genes that share domains with PSME2: view

Function for PSME2 Gene

Molecular function for PSME2 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (prosome,macropain,20S),proteasome activator PA28 beta,homologous to Ki antigen,stimulated by interferon gamma,tightly linked to PSME1
UniProtKB/Swiss-Prot Function:
Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma.
genes like me logo Genes that share phenotypes with PSME2: view

Animal Models for PSME2 Gene

MGI Knock Outs for PSME2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PSME2 Gene

Localization for PSME2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSME2 Gene COMPARTMENTS Subcellular localization image for PSME2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PSME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PSME2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSME2 Gene

Pathways & Interactions for PSME2 Gene

SuperPathways for PSME2 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin-3, 5 and GM-CSF signaling
3 Infectious disease
.48
4 Immune System
5 Cell Cycle, Mitotic
.61
genes like me logo Genes that share pathways with PSME2: view

Pathways by source for PSME2 Gene

1 BioSystems pathway for PSME2 Gene
2 KEGG pathways for PSME2 Gene
1 GeneGo (Thomson Reuters) pathway for PSME2 Gene

Gene Ontology (GO) - Biological Process for PSME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSME2: view

No data available for SIGNOR curated interactions for PSME2 Gene

Drugs & Compounds for PSME2 Gene

(2) Drugs for PSME2 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 769
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSME2: view

Transcripts for PSME2 Gene

Unigene Clusters for PSME2 Gene

Proteasome (prosome, macropain) activator subunit 2 (PA28 beta):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSME2 Gene

No ASD Table

Relevant External Links for PSME2 Gene

GeneLoc Exon Structure for
PSME2
ECgene alternative splicing isoforms for
PSME2

Expression for PSME2 Gene

mRNA expression in normal human tissues for PSME2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSME2 Gene

This gene is overexpressed in Liver, secretome (8.8) and Lymph node (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSME2 Gene



SOURCE GeneReport for Unigene cluster for PSME2 Gene Hs.434081

genes like me logo Genes that share expression patterns with PSME2: view

Protein tissue co-expression partners for PSME2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSME2 Gene

Orthologs for PSME2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PSME2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSME2 35
  • 92.89 (n)
  • 96.23 (a)
PSME2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSME2 35
  • 93.58 (n)
  • 97.07 (a)
PSME2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psme2 35
  • 90.66 (n)
  • 93.72 (a)
Psme2 16
Psme2 36
  • 94 (a)
OneToMany
Psme2b 36
  • 94 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia PSME2 35
  • 99.58 (n)
  • 99.58 (a)
PSME2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psme2 35
  • 91.18 (n)
  • 92.86 (a)
oppossum
(Monodelphis domestica)
Mammalia PSME2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSME2 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSME2 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psme2 35
  • 61.06 (n)
  • 58.4 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17544 35
zebrafish
(Danio rerio)
Actinopterygii psme2 35
  • 63.46 (n)
  • 61.92 (a)
psme2 36
  • 60 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8328 35
fruit fly
(Drosophila melanogaster)
Insecta REG 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y66D12A.9 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
Species with no ortholog for PSME2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSME2 Gene

ENSEMBL:
Gene Tree for PSME2 (if available)
TreeFam:
Gene Tree for PSME2 (if available)

Paralogs for PSME2 Gene

Paralogs for PSME2 Gene

(2) SIMAP similar genes for PSME2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with PSME2: view

Variants for PSME2 Gene

Sequence variations from dbSNP and Humsavar for PSME2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_063111 -

Structural Variations from Database of Genomic Variants (DGV) for PSME2 Gene

Variant ID Type Subtype PubMed ID
nsv901498 CNV Loss 21882294

Variation tolerance for PSME2 Gene

Residual Variation Intolerance Score: 67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSME2 Gene

HapMap Linkage Disequilibrium report
PSME2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSME2 Gene

Disorders for PSME2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSME2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ulceroglandular tularemia
- elite association - COSMIC cancer census association via MalaCards
Search PSME2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSME2

Genetic Association Database (GAD)
PSME2
Human Genome Epidemiology (HuGE) Navigator
PSME2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSME2
genes like me logo Genes that share disorders with PSME2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSME2 Gene

Publications for PSME2 Gene

  1. Primary structures of two homologous subunits of PA28, a gamma- interferon-inducible protein activator of the 20S proteasome. (PMID: 7789512) Ahn J.Y. … DeMartino G.N. (FEBS Lett. 1995) 2 3 4 67
  2. Impaired expression of proteasome subunits and human leukocyte antigens class I in human colon cancer cells. (PMID: 12519221) Miyagi T. … Hayashi N. (J. Gastroenterol. Hepatol. 2003) 3 23
  3. In vivo characterization of the proteasome regulator PA28. (PMID: 8663520) Ahn K. … Yang Y. (J. Biol. Chem. 1996) 3 23
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for PSME2 Gene

Sources for PSME2 Gene

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