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PSME1 Gene

protein-coding   GIFtS: 67
GCID: GC14P024605

Proteasome (Prosome, Macropain) Activator Subunit 1 (PA28...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Proteasome (Prosome, Macropain) Activator Subunit 1 (PA28 Alpha)1 2     PA28A2
IFI51112 3 5     REGalpha2
Activator Of Multicatalytic Protease Subunit 12 3     Interferon-Gamma IEF SSP 51112
Interferon Gamma Up-Regulated I-5111 Protein2 3     Interferon-Gamma-Inducible Protein 51112
11S Regulator Complex Subunit Alpha2 3     Proteasome Activator Complex Subunit 12
PA28alpha2 3     PA28a3
IGUP I-51112 3     REG-alpha3
29-KD MCP Activator Subunit2     Proteasome Activator 28 Subunit Alpha3

External Ids:    HGNC: 95681   Entrez Gene: 57202   Ensembl: ENSG000000920107   OMIM: 6006545   UniProtKB: Q063233   
ORGUL members:         

Export aliases for PSME1 gene to outside databases

Previous GC identifers: GC14P021977 GC14P018392 GC14P022595 GC14P023675 GC14P023661 GC14P004720


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PSME1 Gene:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes,
a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are
composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a
base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in
an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome,
the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate
regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta
and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator,
one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to
form a heterohexameric ring. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
Jul 2013)

GeneCards Summary for PSME1 Gene:
PSME1 (proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)) is a protein-coding gene. GO annotations related to this gene include endopeptidase activator activity. An important paralog of this gene is PSME2.

UniProtKB/Swiss-Prot: PSME1_HUMAN, Q06323
Function: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28
activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the
proteasome

Gene Wiki entry for PSME1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the PSME1 gene promoter:
         TBP   SREBP-1a   AML1a   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSME1 promoter sequence
   Search Chromatin IP Primers for PSME1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSME1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q11.2

PSME1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSME1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P024605:  view genomic region     (about GC identifiers)

Start:
24,605,367 bp from pter      End:
24,608,176 bp from pter
Size:
2,810 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PSME1_HUMAN, Q06323 (See protein sequence)
Recommended Name: Proteasome activator complex subunit 1  
Size: 249 amino acids; 28723 Da
Subunit: Heterodimer of PSME1 and PSME2, which forms a hexameric ring. PSME1 can form homoheptamers
1 PDB 3D structure from and Proteopedia for PSME1:
1AVO (3D)    
Secondary accessions: A6NJG9 Q6IBM2 Q9UEF4
Alternative splicing: 2 isoforms:  Q06323-1   Q06323-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for PSME1: NX_Q06323

Explore proteomics data for PSME1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys13, Lys24, Lys35, Lys176, Lys245
  • Modification sites at PhosphoSitePlus

  • See PSME1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001268457.1  NP_001268458.1  NP_006254.1  NP_788955.1  

    ENSEMBL proteins: 
     ENSP00000206451   ENSP00000452843   ENSP00000372155   ENSP00000453976   ENSP00000453340  
    Reactome Protein details: Q06323

    PSME1 Human Recombinant Protein Products:

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    Novus Biologicals PSME1 Lysates
    Sino Biological Recombinant Protein for PSME1
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PSM: Proteasome (prosome, macropain) subunits

    3 InterPro protein domains:
     IPR003186 Proteasome_activ_pa28_C
     IPR003185 Proteasome_activ_pa28_N
     IPR009077 Proteasome_activ_pa28

    Graphical View of Domain Structure for InterPro Entry Q06323

    ProtoNet protein and cluster: Q06323

    1 Blocks protein domain: IPB003185 Proteasome activator pa28

    UniProtKB/Swiss-Prot: PSME1_HUMAN, Q06323
    Similarity: Belongs to the PA28 family


    Find genes that share domains with PSME1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PSME1_HUMAN, Q06323
    Function: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28
    activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the
    proteasome
    Induction: By IFNG/IFN-gamma

         Genatlas biochemistry entry for PSME1:
    multicatalytic proteinase complex (prosome,macropain,20S),proteasome activator PA28 alpha, homologous to Ki
    antigen,stimulated by interferon gamma

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0061133endopeptidase activator activity IEA--
         
    Find genes that share ontologies with PSME1           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Psme1):
     tumorigenesis 

    Find genes that share phenotypes with PSME1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Psme1/Psme2Psme1/tm1Tchi for PSME1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PSME1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PSME1

    miRNA
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    miRTarBase miRNAs that target PSME1:
    hsa-mir-331-3p (MIRT043440), hsa-mir-1 (MIRT023950), hsa-mir-421 (MIRT039420), hsa-mir-186-5p (MIRT045261), hsa-mir-324-5p (MIRT043135), hsa-mir-26b-5p (MIRT029951)

    Block miRNA regulation of human, mouse, rat PSME1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate PSME1:
    hsa-miR-550a hsa-miR-1289
    SwitchGear 3'UTR luciferase reporter plasmidPSME1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PSME1

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    GenScript: all cDNA clones in your preferred vector (see all 2): PSME1 (NM_006263)
    Sino Biological Human cDNA Clone for PSME1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSME1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSME1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSME1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex TAS8811196
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm TAS16130169
    GO:0005829cytosol TAS--
    GO:0008537proteasome activator complex IEA--

    Find genes that share ontologies with PSME1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PSME1 About   (see all 15)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    CDK-mediated phosphorylation and removal of Cdc60.94
    Destabilization of mRNA by AUF1 (hnRNP D0)0.88
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    G1/S DNA Damage Checkpoints0.87
    Ubiquitin-dependent degradation of Cyclin D10.94
    CDT1 association with the CDC6-ORC-origin complex0.87
    Ubiquitin-dependent degradation of Cyclin D0.94
    SCF(Skp2)-mediated degradation of p27/p210.86
    2Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    4Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    5E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    G1/S Transition0.81


    Find genes that share SuperPaths with PSME1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PSME1
        Protein Stability

    1 GeneGo (Thomson Reuters) Pathway for PSME1
        Immune response Antigen presentation by MHC class I

    1 BioSystems Pathway for PSME1
        Proteasome Degradation


    Selected Reactome Pathways for PSME1 (see all 24)
        SCF(Skp2)-mediated degradation of p27/p21
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
    SCF-beta-TrCP mediated degradation of Emi1
    Ubiquitin-dependent degradation of Cyclin D1
    Orc1 removal from chromatin


    2 Kegg Pathways  (Kegg details for PSME1):
        Proteasome
    Antigen processing and presentation

        Pathway & Disease-focused RT2 Profiler PCR Array including PSME1: 
              Interferons & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PSME1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PSME1 (Q063232, 3 ENSP000003721554) via UniProtKB, MINT, STRING, and/or I2D (see all 125)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271421 I2D: score=2 
    SMN2Q166372, 3MINT-8271421 I2D: score=2 
    AIMP2Q131552, 3MINT-8259006 I2D: score=2 
    ATP1B1P050262, 3MINT-8249168 I2D: score=2 
    CDC37Q165432, 3MINT-8250955 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--

    Find genes that share ontologies with PSME1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PSME1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PSME1 gene (4 alternative transcripts): 
    NM_001281528.1  NM_001281529.1  NM_006263.3  NM_176783.2  

    Unigene Cluster for PSME1:

    Proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
    Hs.75348  [show with all ESTs]
    Unigene Representative Sequence: BQ073751
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000206451(uc001wmg.3) ENST00000559123 ENST00000561059 ENST00000561142
    ENST00000382708(uc001wmh.3) ENST00000561435 ENST00000470718 ENST00000559741
    ENST00000560420 ENST00000558112
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate PSME1:
    hsa-miR-550a hsa-miR-1289
    SwitchGear 3'UTR luciferase reporter plasmidPSME1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PSME1
      QuantiFast Probe-based Assays in human, mouse, rat PSME1

    Additional mRNA sequence: 

    AK307150.1 AK308572.1 AK311490.1 AK312211.1 BC000352.2 BC007503.2 BT019337.1 BX248293.1 
    CR456780.1 CR541658.1 DQ185047.1 L07633.1 

    23 DOTS entries:

    DT.75116742  DT.91964520  DT.100885025  DT.100885017  DT.120746733  DT.92449416  DT.100885015  DT.100885021 
    DT.120746644  DT.120746759  DT.95140609  DT.95165751  DT.100044905  DT.95165750  DT.120746649  DT.92449394 
    DT.100710753  DT.100885014  DT.100885020  DT.92449409  DT.95103152  DT.95295793  DT.100838815 

    Selected AceView cDNA sequences (see all 440):

    CR622317 BQ876956 AI755250 BQ029689 BE408970 CR614004 CN483326 BI836363 
    BM693220 NM_176783 CR594470 CD367564 BG177576 BQ050235 CA424524 NM_006263 
    D11943 BI039778 AA302339 BM703911 AA358894 BU684274 CD742896 BE887035 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PSME1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for PSME1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PSME1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGATCCGCA
    PSME1 Expression
    About this image


    PSME1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Liver (Hepatobiliary System)
    PSME1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PSME1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75348
        Pathway & Disease-focused RT2 Profiler PCR Array including PSME1: 
              Interferons & Receptors in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for PSME1
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    QuantiFast Probe-based Assays in human, mouse, rat PSME1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSME1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PSME1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Psme11 , 5 proteasome (prosome, macropain) 28 subunit, alpha5
    proteasome (prosome, macropain) activator subunit 1 more1
    89.96(n)1
    94.78(a)1
      14 (28.19 cM)5
    191861  NM_011189.11  NP_035319.11 
     555781235 
    lizard
    (Anolis carolinensis)
    Reptilia PSME16
    proteasome (prosome, macropain) activator subunit ...
    54(a)
    1 ↔ 1
    GL344031.1(20183-33510)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.240112 Xenopus laevis transcribed sequence with weak similarity more 77.25(n)    BJ098760.1 
    zebrafish
    (Danio rerio)
    Actinopterygii psme12 proteasome activator subunit 1 76.27(n)   30648  AF195052.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta REG6
    REG
    32(a)
    1 → many
    X(13106366-13108008)
    worm
    (Caenorhabditis elegans)
    Secernentea Y66D12A.96
    Protein Y66D12A.9 (Y66D12A.9) mRNA, complete cds
    32(a)
    1 → many
    III(11568137-11573343) WBGene00013435


    ENSEMBL Gene Tree for PSME1 (if available)
    TreeFam Gene Tree for PSME1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PSME1 gene
    PSME22  PSME32  
    2 SIMAP similar genes for PSME1 using alignment to 5 protein entries:     PSME1_HUMAN (see all proteins):
    PSME2    PSME3

    Find genes that share paralogs with PSME1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PSME1 (see all 129)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844469381,2
    --24603600(+) TCTCAA/GGTTCA 2 -- us2k10--------
    rs1420854311,2
    C--24603609(+) CAAGCA/GATCTC 2 -- us2k10--------
    rs1889356421,2
    --24603879(+) GAAATA/TCAAAT 2 -- us2k10--------
    rs1160640171,2
    C,F--24603895(+) TGTCTA/GTAAAA 2 -- us2k11Minor allele frequency- G:0.11WA 118
    rs1815820131,2
    --24603973(+) ACAGAC/TACTGT 2 -- us2k10--------
    rs3692015941,2
    C--24604314(+) CCCCA-/ACACA 
     CACACAC
    ACACA
    4 -- us2k1 cds10--------
    rs720221161,2
    C--24604315(+) CCCAA-/AC/ACACACAC
    /ACACACACACAC
    CACAC
    4 -- us2k1 cds10--------
    rs1862003151,2
    --24604326(+) ACACAC/TACACA 2 -- us2k10--------
    rs567093661,2
    C--24604400(+) AAAAA-/A/AC  
            
    CACCT
    2 -- us2k10--------
    rs111585631,2
    C,H--24604401(+) AAAAAA/CACCTG 2 -- us2k13Minor allele frequency- C:0.17NA CSA 6

    HapMap Linkage Disequilibrium report for PSME1 (24605367 - 24608176 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PSME1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901498CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PSME1
    DNA2.0 Custom Variant and Variant Library Synthesis for PSME1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600654    OMIM disorders: --


    Find genes that share disorders with PSME1           About GenesLikeMe

    1 Novoseek inferred disease relationship for PSME1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 9721876 (1)


    Export disorders for PSME1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PSME1 gene, integrated from 10 sources (see all 98):
    (articles sorted by number of sources associating them with PSME1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interferon-gamma up-regulates a unique set of proteins in human keratinocytes. Molecular cloning and expression of the cDNA encoding the RGD-sequence-containing protein IGUP I-5111. (PubMed id 8269930)1, 2, 3, 9 Honore B.... Celis J.E. (Eur. J. Biochem. 1993)
    2. The proteasome 11S regulator subunit REG alpha (PA28 alpha) is a heptamer. (PubMed id 9385652)1, 2, 9 Johnston S.C.... Hill C.P. (Protein Sci. 1997)
    3. Structure of the proteasome activator REGalpha (PA28alpha). (PubMed id 9403698)1, 2, 9 Knowlton J.R.... Hill C.P. (Nature 1997)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Organization of the genes encoding the human proteasome activators PA28alpha and beta. (PubMed id 10199920)1, 2 McCusker D.... Trowsdale J. (Immunogenetics 1999)
    6. Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and beta-subunit genes. (PubMed id 9590240)1, 2 Kohda K....Kasahara M. (J. Immunol. 1998)
    7. Molecular cloning and expression of a gamma-interferon-inducible activator of the multicatalytic protease. (PubMed id 8051173)1, 2 Realini C.... Rechsteiner M. (J. Biol. Chem. 1994)
    8. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (Electrophoresis 1992)
    9. Autoimmune response to proteasome activator 28alpha in patients with connective tissue diseases. (PubMed id 14760793)1, 9 Matsushita M....Hashimoto H. (J. Rheumatol. 2004)
    10. The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing. (PubMed id 12419264)1, 9 Huang X....Dubiel W. (J. Mol. Biol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5720 HGNC: 9568 AceView: PSME1 Ensembl:ENSG00000092010 euGenes: HUgn5720
    ECgene: PSME1 Kegg: 5720 H-InvDB: PSME1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PSME1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PSME1 gene:
    Search GeneIP for patents involving PSME1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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