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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PSMD9 Gene

protein-coding GIFtS: 61
GCID: GC12P122326

proteasome (prosome, macropain) 26S subunit, non-ATPase,...

Explore 41 diseases affiliated with
PSMD9 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 9¹ ²		26S Proteasome Non-ATPase Regulatory Subunit 9²
Rpn4¹ ²		Homolog Of Rat Bridge 1²
P27¹		Proteasome 26S Non-ATPase Regulatory Subunit 9²
26S Proteasome Regulatory Subunit P27² ³

External Ids:	HGNC: 9567¹	Entrez Gene: 5715²	Ensembl: ENSG00000110801⁷	OMIM: 603146⁵	UniProtKB: O00233³

Export aliases for PSMD9 gene to outside databases

Previous GC identifers: GC12P120852 GC12M121795 GC12P122095 GC12P120724 GC12P120789 GC12P119337

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PSMD9:

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a

20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed

of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which

contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits.

Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an

ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the

immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S

regulator. Three transcript variants encoding two different isoforms have been found for this gene. (provided by

RefSeq, May 2012)

UniProtKB/Swiss-Prot: PSMD9_HUMAN, O00233

Function: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the

PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3

module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process

Gene Wiki entry for PSMD9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009775.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PSMD9 gene promoter:
GR AML1a GR-beta HTF XBP-1 N-Myc PPAR-gamma1 PPAR-gamma2 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PSMD9 promoter sequence

Search SABiosciences Chromatin IP Primers for PSMD9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSMD9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31-q24.32 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.31-q24.32

PSMD9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMD9 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P122326: view genomic region (about GC identifiers)

Start:	122,326,637 bp from pter	End:	122,356,203 bp from pter
Size:	29,567 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PSMD9_HUMAN, O00233 (See protein sequence)

Recommended Name: 26S proteasome non-ATPase regulatory subunit 9

Size: 223 amino acids; 24682 Da

Subunit: Interacts with PSMC3. Part of a transient complex (modulator) containing PSMD9, PSMC6 and PSMC3 formed during

the assembly of the 26S proteasome

Caution: Was initially identified as a component of the 26S proteasome

Secondary accessions: B2RD35 G3V1Q6 Q9BQ42

Alternative splicing: 3 isoforms: O00233-1 O00233-2 O00233-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PSMD9: NX_O00233

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O00233

PSMD9 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001248329.1 NP_002804.2

ENSEMBL proteins:

ENSP00000440485 ENSP00000445058 ENSP00000442210 ENSP00000261817 ENSP00000443081

ENSP00000440500 ENSP00000443968 ENSP00000443929 ENSP00000340847

Reactome Protein details: O00233
Human Recombinant Protein Products for PSMD9:

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	Uscn Proteins for PSMD9

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	10567574
GO:0005654	nucleoplasm	TAS	--
GO:0005829	cytosol	TAS	--
GO:0005838	proteasome regulatory particle	NAS	9653651
GO:0008540	colocalizes with proteasome regulatory particle, base subcomplex	IDA	19490896

PSMD9 for ontologies About GeneDecksing

PSMD9 Antibody Products:

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	Uscn ELISAs and CLIAs for PSMD9

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PSMD9 for domains About GeneDecksing

1 InterPro domain/family:

IPR001478 PDZ

Graphical View of Domain Structure for InterPro Entry O00233

ProtoNet protein and cluster: O00233

1 Blocks protein family: IPB001478 PDZ/DHR/GLGF domain

UniProtKB/Swiss-Prot: PSMD9_HUMAN, O00233

Similarity: Belongs to the proteasome subunit p27 family

Similarity: Contains 1 PDZ (DHR) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PSMD9_HUMAN, O00233

Function: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the

PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3

module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process

Genatlas biochemistry entry for PSMD9:

multicatalytic proteinase proteasome (prosome,macropain,26S) component,19/22S regulator of proteasome,non ATPase

subunit p27 (23-25kDa),with two alternatively spliced isogforms,ubiquitously expressed with highly expresseion in

liver and kidney,homolog to S cerevisiae NAS2 gene

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003713	transcription coactivator activity	ISS	10567574
GO:0005515	protein binding	IPI	19490896
GO:0043425	bHLH transcription factor binding	ISS	10567574

PSMD9 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for PSMD9:

Synthetic lethal with c-Myc af

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PSMD9

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		hsa-miR-30c hsa-miR-3607-3p hsa-miR-30d hsa-miR-520a-5p hsa-miR-30a hsa-miR-9 hsa-miR-532-5p hsa-miR-342-5p

		SwitchGear 3'UTR luciferase reporter plasmid: PSMD9 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMD9

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/75 pathways (see all 75)
Ubiquitinated Orc1 is degraded by the proteasome	1.00	Degradation of ubiquitinated p27/p21 by the 26S proteasome	0.75
Proteasomal cleavage of substrate	0.98	SCF(Skp2)-mediated degradation of p27/p21	0.75
Proteasome mediated degradation of PAK-2p34	0.98	APC/C:Cdh1-mediated degradation of Skp2	0.74
Proteasomal cleavage of substrate	0.98	APC/C:Cdc20 mediated degradation of Securin	0.74

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

HIV Infection

	HIV Infection	1.00			Transcription_Ligand-Dependent Transcription of Retinoid-Target genes	0.28
	Host Interactions of HIV factors	0.64			Transcription Ligand-Dependent Transcription of Retinoid-Target genes	0.28

Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway	1.00			Parkin-Ubiquitin Proteasomal System pathway	0.93
	Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway	0.93

Antigen processing: Ubiquitination & Proteasome degradation

Antigen processing: Ubiquitination & Proteasome degradation

1.00

Class I MHC mediated antigen processing & presentation

0.83

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for PSMD9

	Immune response Antigen presentation by MHC class I
	Transcription Ligand-Dependent Transcription of Retinoid-Target genes
	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PSMD9

	Remodeling of Adherens Junctions
	RAR-Gamma-RXR-Alpha Degradation

3 GeneGo (Thomson Reuters) Pathways for PSMD9

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Transcription Ligand-Dependent Transcription of Retinoid-Target genes
	Immune response Antigen presentation by MHC class I

2 BioSystems Pathways for PSMD9

	Parkin-Ubiquitin Proteasomal System pathway
	Proteasome Degradation

5/98 Reactome Pathways for PSMD9 (see all 98)

	Ubiquitinated geminin is degraded by the proteasome
	Proteolytic degradation of ubiquitinated-Cdc25A
	Orc1 removal from chromatin
	CDK-mediated phosphorylation and removal of Cdc6
	ER-Phagosome pathway

PSMD9 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PSMD9

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/128 Interacting proteins for PSMD9 (O00233^{1, 2, 3} ENSP00000261817⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 128)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PSMC3	P17980¹^,³, ENSP00000298852⁴	EBI-750973,EBI-359720 I2D: score=7 STRING: ENSP00000298852
PSMC6	P62333¹^,²^,³, ENSP00000401802⁴	EBI-750973,EBI-357669 MINT-67981 I2D: score=8 STRING: ENSP00000401802
PSMC1	P62191³, ENSP00000261303⁴	I2D: score=6 STRING: ENSP00000261303
NSF	P46459³, ENSP00000381293⁴	I2D: score=3 STRING: ENSP00000381293
PSMB1	P20618³, ENSP00000262193⁴	I2D: score=3 STRING: ENSP00000262193

About this table

Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000084	S phase of mitotic cell cycle	TAS	--
GO:0000209	protein polyubiquitination	TAS	--
GO:0000216	M/G1 transition of mitotic cell cycle	TAS	--

PSMD9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PSMD9 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PSMD9
1 Novoseek chemical compound relationship for PSMD9 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
egcg	40.9	1	12393936 (1)

Search CenterWatch for drugs/clinical trials and news about PSMD9

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PSMD9 gene (2 alternative transcripts):

NM_001261400.1 NM_002813.5

Unigene Cluster for PSMD9:

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 9

Hs.131151 [show with all ESTs]

Unigene Representative Sequence: NM_002813

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000541212(uc001ubl.3 uc009zxj.3) ENST00000537407 ENST00000540962

ENST00000261817 ENST00000538613 ENST00000543699 ENST00000535293 ENST00000544724

ENST00000544254 ENST00000361485 ENST00000340175

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSMD9
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		hsa-miR-30c hsa-miR-3607-3p hsa-miR-30d hsa-miR-520a-5p hsa-miR-30a hsa-miR-9 hsa-miR-532-5p hsa-miR-342-5p

		SwitchGear 3'UTR luciferase reporter plasmid: PSMD9 3' UTR sequence

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Additional cDNA sequence:

AK315389.1 BC002383.2 BC004184.2 BC004213.2 NR_048555.1

8 DOTS entries:

DT.445685 DT.100781450 DT.100698307 DT.95300615 DT.95104899 DT.95342635 DT.100781453 DT.75176895

24/280 AceView cDNA sequences (see all 280):

BF510741 AB003177 AI202368 AL833930 BG676155 BM826633 AW242490 CB241016

BM552926 BQ939922 AL530953 BM713768 BM982692 AW079701 D82285 BU738828

AW627628 BU740453 AA640616 BG149414 NM_002813 BU740504 AI580764 CB241096

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for PSMD9 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	·	7c
SP1:							-
SP2:							-
SP3:
SP4:							-		-		-		-		-
SP5:											-		-

ECgene alternative splicing isoforms for PSMD9

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PSMD9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCGCAAAC

About this image

PSMD9 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PSMD9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PSMD9

SOURCE GeneReport for Unigene cluster: Hs.131151

UniProtKB/Swiss-Prot: PSMD9_HUMAN, O00233

Tissue specificity: Expressed in all tissues tested, highly expressed in liver and kidney

SABiosciences Custom PCR Arrays for PSMD9

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSMD9

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMD9

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD9 gene from 9/32 species (see all 32) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PSMD9¹	proteasome (prosome, macropain) 26S subunit, non-ATPase, more	74.06(n) 71.92(a)		416853 NM_001006189.1 NP_001006189.1
lizard (Anolis carolinensis)	Reptilia	--	--	72(a)	1 → many	GL343550.1(328915-336592)
African clawed frog (Xenopus laevis)	Amphibia	BC041532.1²	--	74.05(n)		BC041532.1
zebrafish (Danio rerio)	Actinopterygii	CK353225.1²	--	73.31(n)		CK353225.1
fruit fly (Drosophila melanogaster)	Insecta	CG9588^{1 , 3}	proteolysis and peptidolysis³ CG9588¹	41(a)³ 52.74(n)¹ 44.28(a)¹		87F7³ 41672¹ NM_142044.3¹ NP_650301.1¹
worm (Caenorhabditis elegans)	Secernentea	C44B7.1^{1 , 3}	hypothetical protein¹	34(a)³ 45.21(n)¹ 37.23(a)¹		II(6901191-6902775)³ 174129¹ NM_063012.5¹ NP_495413.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	NAS2(YIL007C)⁴ NAS2¹	Proteasome-interacting protein involved in the assembly more⁴ Nas2p¹	46.06(n)¹ 39.25(a)¹		9(343656-342994)⁴ 854810^{1, 4} NP_012259.3¹ NP_012259.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G57950¹	26S proteasome non-ATPase regulatory subunit 9	42.86(n) 30.61(a)		835906 NM_125180.2 NP_568872.1
rice (Oryza sativa)	Liliopsida	Os09g0420600¹	hypothetical protein	46.07(n) 32.98(a)		4347083 NM_001069732.1 NP_001063197.1

ENSEMBL Gene Tree for PSMD9 (if available)
TreeFam Gene Tree for PSMD9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PSMD9 gene

ENSG00000256950²

PSMD9 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2707064^1,2		--	122328531(-)	`CTGGGC/TGTGGT`	3	--	int¹		0	--	--	--	--
rs190234126^1,2		--	122328533(+)	`CACGCC/TCAGCT`	3	--	int¹		0	--	--	--	--
rs182416561^1,2		--	122328642(+)	`CAAAGC/TGTTGG`	3	--	int¹		0	--	--	--	--
rs185748987^1,2		--	122328759(+)	`GTCAGA/GTGCTT`	3	--	int¹		0	--	--	--	--
rs189412937^1,2		--	122328805(+)	`AGCTGC/TTGTTG`	3	--	int¹		0	--	--	--	--
rs61954311^1,2	C,F	--	122329063(+)	`TGGGCG/ATGGTG`	3	--	int¹		2		NA	4
rs7486904^1,2	C,A	--	122329235(+)	`ggtgcA/Ggtggc`	3	--	int¹		0	--	--	--	--
rs180988265^1,2		--	122329416(+)	`CAGGAC/GAATGG`	3	--	int¹		0	--	--	--	--
rs1168674^1,2	C,F	--	122329478(+)	`TTCAGT/CCTGGG`	3	--	int¹		6		NA WA CSA	11
rs7978966^1,2	C,A	--	122329623(+)	`CCTGGA/CCAACA`	3	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PSMD9 (122326637 - 122356203 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PSMD9: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PSMD9

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PSMD9 for disorders           About GeneDecksing

OMIM gene information: 603146    OMIM disorders: --

20/41 diseases for PSMD9 (see all 41):    About MalaCards

carpal tunnel syndrome gastrointestinal stromal tumor squamous cell carcinoma oral squamous cell carcinoma

esophageal squamous cell carcinoma ewing's family of tumors pleomorphic adenoma adult t-cell leukemia

leukemia/lymphoma hypertensive retinopathy diabetic retinopathy diabetic neuropathy

renal cell carcinoma multiple myeloma t-cell leukemia carcinoma

neuropathy endometrial carcinoma hypercholesterolemia prostate cancer

1 disease from the University of Copenhagen DISEASES database for PSMD9:

Hypertensive retinopathy

8 Novoseek disease relationships for PSMD9 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glioma	38	4	19331209 (1), 16489017 (1), 19825946 (1)
glioblastoma	35.6	2	11250155 (1), 9364514 (1)
tumors	27.3	13	19139918 (2), 11588135 (1), 16606541 (1), 15161026 (1) (see all 9)
cancer	24.1	5	15695111 (3), 19349901 (1), 12670908 (1)
prostate cancer	23.6	3	17541980 (1), 19165859 (1), 12393936 (1)
carcinoma squamous cell	10.6	3	19349901 (1), 15161026 (1), 15695111 (1)
hyperplasia	3.09	1	17096381 (1)
metastasis	0	1	16606541 (1)

Human Genome Epidemiology (HuGE) Navigator: PSMD9 (2 documents)

Export disorders for PSMD9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PSMD9 gene, integrated from 9 sources (see all 124):
(articles sorted by number of sources associating them with PSMD9)

Utopia: connect your pdf to the dynamic
world of online information

cDNA cloning and characterization of a human proteasomal modulator subunit, p27 (PSMD9). (PubMed id 9653651)^{1, 2, 3, 9} Watanabe T.K....Tanaka K. (1998)
Assembly pathway of the Mammalian proteasome base sub complex is mediated by multiple specific chaperones. (PubMed id 19490896)^{1, 2} Kaneko T....Murata S. (2009)
Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)^{1, 2} Wang A.G....Kim N.S. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Potential role of Jun activation domain-binding protei n 1 and phosphorylated p27 expression in prognosis of glioma. (PubMed id 21837501)¹ He S.M....Gao G.D. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (2012)
Yin Yang 1 plays an essential role in breast cancer an d negatively regulates p27. (PubMed id 22440256)¹ Wan M....Sui G. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5715	HGNC: 9567	AceView: PSMD9andMGC33630	Ensembl:ENSG00000110801	euGenes: HUgn5715
ECgene: PSMD9	H-InvDB: PSMD9

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PSMD9	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PSMD9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PSMD9 gene:
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GeneCards and IP:
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