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Aliases for PSMD9 Gene

Aliases for PSMD9 Gene

  • Proteasome 26S Subunit, Non-ATPase 9 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 9 2 3
  • 26S Proteasome Regulatory Subunit P27 3 4
  • 26S Proteasome Non-ATPase Regulatory Subunit 9 3
  • Proteasome 26S Non-ATPase Regulatory Subunit 9 3
  • Homolog Of Rat Bridge 1 3
  • Rpn4 3
  • P27 3

External Ids for PSMD9 Gene

Previous GeneCards Identifiers for PSMD9 Gene

  • GC12P120852
  • GC12M121795
  • GC12P122095
  • GC12P120724
  • GC12P120789
  • GC12P122326
  • GC12P119337
  • GC12P121950
  • GC12P121957
  • GC12P121963
  • GC12P121970
  • GC12P121975

Summaries for PSMD9 Gene

Entrez Gene Summary for PSMD9 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for PSMD9 Gene

PSMD9 (Proteasome 26S Subunit, Non-ATPase 9) is a Protein Coding gene. Diseases associated with PSMD9 include Nerve Compression Syndrome and Carpal Tunnel Syndrome, Familial. Among its related pathways are RET signaling and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transcription coactivator activity and bHLH transcription factor binding. An important paralog of this gene is ENSG00000256950.

UniProtKB/Swiss-Prot for PSMD9 Gene

  • Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.

Gene Wiki entry for PSMD9 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD9 Gene

Genomics for PSMD9 Gene

Regulatory Elements for PSMD9 Gene

Enhancers for PSMD9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G121783 1.9 FANTOM5 ENCODE dbSUPER 36.7 -92.7 -92739 24.5 CREB3L1 MLX AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 PSMD9 ENSG00000272849 ZCCHC8 KNTC1 SETD1B LINC01089 HPD ENSG00000256950 ANAPC5 BCL7A
GH12G122061 1.7 Ensembl ENCODE dbSUPER 29.2 +174.7 174736 4.6 CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 ZCCHC8 PSMD9 KNTC1 SETD1B ANAPC5 LOC100506691 ENSG00000255856 BCL7A ENSG00000256950 HPD
GH12G121663 1.5 Ensembl ENCODE dbSUPER 25.3 -224.3 -224308 2.0 HDGF PKNOX1 ATF1 ARNT WRNIP1 SIN3A YY1 ETS1 GTF3C2 ZNF766 ZCCHC8 KNTC1 PSMD9 SETD1B ANAPC5 ENSG00000272849 LINC01089 MORN3 LOC105370034
GH12G121708 1.6 FANTOM5 Ensembl ENCODE 23.7 -175.3 -175283 9.8 FOXA2 PKNOX1 ARNT AGO1 ARID4B SIN3A DMAP1 FEZF1 YY1 ZNF766 PSMD9 ZCCHC8 KNTC1 SETD1B LOC101928346 KDM2B HPD ENSG00000256950 TMEM120B ANAPC5
GH12G121887 1.2 ENCODE 26.9 +0.4 361 2.3 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 ZCCHC8 KNTC1 PSMD9 SETD1B ENSG00000272849 WDR66 ANAPC5 ENSG00000256950 ENSG00000283389
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSMD9 on UCSC Golden Path with GeneCards custom track

Promoters for PSMD9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058512 169 1801 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21

Genomic Location for PSMD9 Gene

Chromosome:
12
Start:
121,888,731 bp from pter
End:
121,918,297 bp from pter
Size:
29,567 bases
Orientation:
Plus strand

Genomic View for PSMD9 Gene

Genes around PSMD9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD9 Gene

Proteins for PSMD9 Gene

  • Protein details for PSMD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00233-PSMD9_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 9
    Protein Accession:
    O00233
    Secondary Accessions:
    • B2RD35
    • G3V1Q6
    • Q9BQ42

    Protein attributes for PSMD9 Gene

    Size:
    223 amino acids
    Molecular mass:
    24682 Da
    Quaternary structure:
    • Interacts with PSMC3. Part of a transient complex (modulator) containing PSMD9, PSMC6 and PSMC3 formed during the assembly of the 26S proteasome.

    Alternative splice isoforms for PSMD9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD9 Gene

Post-translational modifications for PSMD9 Gene

  • Ubiquitination at isoforms=2117 and isoforms=3211
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for PSMD9
  • Cloud-Clone Corp. Antibodies for PSMD9

No data available for DME Specific Peptides for PSMD9 Gene

Domains & Families for PSMD9 Gene

Gene Families for PSMD9 Gene

Protein Domains for PSMD9 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PSMD9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00233

UniProtKB/Swiss-Prot:

PSMD9_HUMAN :
  • Belongs to the proteasome subunit p27 family.
Family:
  • Belongs to the proteasome subunit p27 family.
genes like me logo Genes that share domains with PSMD9: view

Function for PSMD9 Gene

Molecular function for PSMD9 Gene

GENATLAS Biochemistry:
multicatalytic proteinase proteasome (prosome,macropain,26S) component,19/22S regulator of proteasome,non ATPase subunit p27 (23-25kDa),with two alternatively spliced isogforms,ubiquitously expressed with highly expresseion in liver and kidney,homolog to S cerevisiae NAS2 gene
UniProtKB/Swiss-Prot Function:
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.

Gene Ontology (GO) - Molecular Function for PSMD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity ISS 10567574
GO:0005515 protein binding IPI 16189514
GO:0043425 bHLH transcription factor binding ISS 10567574
genes like me logo Genes that share ontologies with PSMD9: view
genes like me logo Genes that share phenotypes with PSMD9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PSMD9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD9 Gene

Localization for PSMD9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMD9 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PSMD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IBA 10567574
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0005838 proteasome regulatory particle NAS 9653651
genes like me logo Genes that share ontologies with PSMD9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD9 Gene

Pathways & Interactions for PSMD9 Gene

SuperPathways for PSMD9 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 HIV Life Cycle
.45
4 Class I MHC mediated antigen processing and presentation
5 Antigen processing-Cross presentation
genes like me logo Genes that share pathways with PSMD9: view

Gene Ontology (GO) - Biological Process for PSMD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006511 ubiquitin-dependent protein catabolic process NAS 9653651
genes like me logo Genes that share ontologies with PSMD9: view

No data available for SIGNOR curated interactions for PSMD9 Gene

Drugs & Compounds for PSMD9 Gene

(2) Drugs for PSMD9 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 807
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0

(1) Additional Compounds for PSMD9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PSMD9: view

Transcripts for PSMD9 Gene

Unigene Clusters for PSMD9 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PSMD9

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: -
SP2: -
SP3:
SP4: - - - - -
SP5: - -

Relevant External Links for PSMD9 Gene

GeneLoc Exon Structure for
PSMD9
ECgene alternative splicing isoforms for
PSMD9

Expression for PSMD9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMD9 Gene

Protein differential expression in normal tissues from HIPED for PSMD9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMD9 Gene



Protein tissue co-expression partners for PSMD9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMD9 Gene:

PSMD9

SOURCE GeneReport for Unigene cluster for PSMD9 Gene:

Hs.131151

mRNA Expression by UniProt/SwissProt for PSMD9 Gene:

O00233-PSMD9_HUMAN
Tissue specificity: Expressed in all tissues tested, highly expressed in liver and kidney.

Evidence on tissue expression from TISSUES for PSMD9 Gene

  • Nervous system(4.6)
  • Muscle(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with PSMD9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMD9 Gene

Orthologs for PSMD9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMD9 34
  • 99.55 (n)
-- 35
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 92 (a)
OneToMany
PSMD9 34
  • 88.94 (n)
cow
(Bos Taurus)
Mammalia PSMD9 34 35
  • 88.39 (n)
mouse
(Mus musculus)
Mammalia Psmd9 34 16 35
  • 84.08 (n)
rat
(Rattus norvegicus)
Mammalia Psmd9 34
  • 83.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 78 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves PSMD9 34 35
  • 74.06 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia psmd9 34
  • 64.5 (n)
zebrafish
(Danio rerio)
Actinopterygii psmd9 34 35
  • 62.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9588 36 34 35
  • 53.33 (n)
worm
(Caenorhabditis elegans)
Secernentea C44B7.1 36
  • 34 (a)
psmd-9 35
  • 34 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes <