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Aliases for PSMD9 Gene

Aliases for PSMD9 Gene

  • Proteasome 26S Subunit, Non-ATPase 9 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 9 2 3
  • 26S Proteasome Regulatory Subunit P27 3 4
  • 26S Proteasome Non-ATPase Regulatory Subunit 9 3
  • Proteasome 26S Non-ATPase Regulatory Subunit 9 3
  • Homolog Of Rat Bridge 1 3
  • Rpn4 3
  • P27 3

External Ids for PSMD9 Gene

Previous GeneCards Identifiers for PSMD9 Gene

  • GC12P120852
  • GC12M121795
  • GC12P122095
  • GC12P120724
  • GC12P120789
  • GC12P122326
  • GC12P119337
  • GC12P121950
  • GC12P121957
  • GC12P121963
  • GC12P121970
  • GC12P121975
  • GC12P122008

Summaries for PSMD9 Gene

Entrez Gene Summary for PSMD9 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for PSMD9 Gene

PSMD9 (Proteasome 26S Subunit, Non-ATPase 9) is a Protein Coding gene. Diseases associated with PSMD9 include Nerve Compression Syndrome and Hypertensive Retinopathy. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and RET signaling. GO annotations related to this gene include transcription coactivator activity and bHLH transcription factor binding. An important paralog of this gene is ENSG00000256950.

UniProtKB/Swiss-Prot for PSMD9 Gene

  • Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.

Gene Wiki entry for PSMD9 Gene

Additional gene information for PSMD9 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD9 Gene

Genomics for PSMD9 Gene

Regulatory Elements for PSMD9 Gene

Enhancers for PSMD9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H121783 1.9 FANTOM5 ENCODE dbSUPER 48.7 -92.7 -92739 24 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC MEF2D ZCCHC8 RSRC2 ENSG00000272849 PSMD9 SETD1B ANAPC5 KNTC1 LINC01089 HPD KDM2B
GH12H121657 1.6 Ensembl ENCODE dbSUPER 37.5 -229.4 -229418 2 HDGF PKNOX1 ARNT ZNF766 MCM3 ZNF592 MEF2D SMARCA4 GLIS1 NBN KNTC1 RSRC2 ZCCHC8 PSMD9 SETD1B LINC01089 ENSG00000272849 LOC101928346 KDM2B ORAI1
GH12H121663 1.5 Ensembl ENCODE dbSUPER 34.7 -224.3 -224308 1 HDGF PKNOX1 ATF1 ARNT YY1 ETS1 GTF3C2 ZNF766 ELK1 ZNF143 KNTC1 ZCCHC8 RSRC2 PSMD9 SETD1B ANAPC5 ENSG00000272849 KDM2B LINC01089 MORN3
GH12H121686 2 FANTOM5 Ensembl ENCODE dbSUPER 21.9 -201.6 -201631 1 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZCCHC8 KNTC1 RSRC2 SETD1B PSMD9 P2RX4 ANAPC5 ENSG00000272849 KDM2B MORN3
GH12H121708 1.6 FANTOM5 Ensembl ENCODE 23.7 -175.3 -175283 9 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 ZNF207 PSMD9 ZCCHC8 KNTC1 RSRC2 SETD1B LOC101928346 KDM2B ENSG00000256950 HPD TMEM120B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSMD9 on UCSC Golden Path with GeneCards custom track

Promoters for PSMD9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058512 169 1801 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 MEF2D ZNF610 GLIS1 RCOR2

Genomic Location for PSMD9 Gene

Chromosome:
12
Start:
121,888,731 bp from pter
End:
121,918,297 bp from pter
Size:
29,567 bases
Orientation:
Plus strand

Genomic View for PSMD9 Gene

Genes around PSMD9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD9 Gene

Proteins for PSMD9 Gene

  • Protein details for PSMD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00233-PSMD9_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 9
    Protein Accession:
    O00233
    Secondary Accessions:
    • B2RD35
    • G3V1Q6
    • Q9BQ42

    Protein attributes for PSMD9 Gene

    Size:
    223 amino acids
    Molecular mass:
    24682 Da
    Quaternary structure:
    • Interacts with PSMC3. Part of a transient complex (modulator) containing PSMD9, PSMC6 and PSMC3 formed during the assembly of the 26S proteasome.

    Alternative splice isoforms for PSMD9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD9 Gene

Post-translational modifications for PSMD9 Gene

  • Ubiquitination at Lys117 and Lys211
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for PSMD9
  • Cloud-Clone Corp. Antibodies for PSMD9

No data available for DME Specific Peptides for PSMD9 Gene

Domains & Families for PSMD9 Gene

Gene Families for PSMD9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PSMD9 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PSMD9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00233

UniProtKB/Swiss-Prot:

PSMD9_HUMAN :
  • Belongs to the proteasome subunit p27 family.
Family:
  • Belongs to the proteasome subunit p27 family.
genes like me logo Genes that share domains with PSMD9: view

Function for PSMD9 Gene

Molecular function for PSMD9 Gene

GENATLAS Biochemistry:
multicatalytic proteinase proteasome (prosome,macropain,26S) component,19/22S regulator of proteasome,non ATPase subunit p27 (23-25kDa),with two alternatively spliced isogforms,ubiquitously expressed with highly expresseion in liver and kidney,homolog to S cerevisiae NAS2 gene
UniProtKB/Swiss-Prot Function:
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.

Phenotypes From GWAS Catalog for PSMD9 Gene

Gene Ontology (GO) - Molecular Function for PSMD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity ISS 10567574
GO:0005515 protein binding IPI 16189514
GO:0043425 bHLH transcription factor binding ISS 10567574
genes like me logo Genes that share ontologies with PSMD9: view
genes like me logo Genes that share phenotypes with PSMD9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PSMD9
  • Applied Biological Materials Clones for PSMD9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD9 Gene

Localization for PSMD9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMD9 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IBA 10567574
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0005838 proteasome regulatory particle NAS 9653651
genes like me logo Genes that share ontologies with PSMD9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD9 Gene

Pathways & Interactions for PSMD9 Gene

SuperPathways for PSMD9 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 HIV Life Cycle
.45
4 Class I MHC mediated antigen processing and presentation
5 Antigen processing-Cross presentation
genes like me logo Genes that share pathways with PSMD9: view

Gene Ontology (GO) - Biological Process for PSMD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006511 ubiquitin-dependent protein catabolic process NAS 9653651
genes like me logo Genes that share ontologies with PSMD9: view

No data available for SIGNOR curated interactions for PSMD9 Gene

Drugs & Compounds for PSMD9 Gene

(2) Drugs for PSMD9 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 814
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0

(1) Additional Compounds for PSMD9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PSMD9: view

Transcripts for PSMD9 Gene

Unigene Clusters for PSMD9 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PSMD9
  • Applied Biological Materials Clones for PSMD9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: -
SP2: -
SP3:
SP4: - - - - -
SP5: - -

Relevant External Links for PSMD9 Gene

GeneLoc Exon Structure for
PSMD9
ECgene alternative splicing isoforms for
PSMD9

Expression for PSMD9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMD9 Gene

Protein differential expression in normal tissues from HIPED for PSMD9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMD9 Gene



Protein tissue co-expression partners for PSMD9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMD9 Gene:

PSMD9

SOURCE GeneReport for Unigene cluster for PSMD9 Gene:

Hs.131151

mRNA Expression by UniProt/SwissProt for PSMD9 Gene:

O00233-PSMD9_HUMAN
Tissue specificity: Expressed in all tissues tested, highly expressed in liver and kidney.

Evidence on tissue expression from TISSUES for PSMD9 Gene

  • Nervous system(4.6)
  • Muscle(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with PSMD9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMD9 Gene

Orthologs for PSMD9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMD9 33
  • 99.55 (n)
-- 34
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 92 (a)
OneToMany
PSMD9 33
  • 88.94 (n)
cow
(Bos Taurus)
Mammalia PSMD9 34 33
  • 88.39 (n)
OneToMany
mouse
(Mus musculus)
Mammalia Psmd9 33 16 34
  • 84.08 (n)
rat
(Rattus norvegicus)
Mammalia Psmd9 33
  • 83.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 78 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves PSMD9 33 34
  • 74.06 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia psmd9 33
  • 64.5 (n)
zebrafish
(Danio rerio)
Actinopterygii psmd9 33 34
  • 62.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9588 35 33 34
  • 53.33 (n)
worm
(Caenorhabditis elegans)
Secernentea C44B7.1 35
  • 34 (a)
psmd-9 34
  • 34 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL013C 33
  • 46.46 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAS2 33 34 36
  • 46.06 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D14135g 33
  • 45.97 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G57950 33
  • 42.81 (n)
rice
(Oryza sativa)
Liliopsida Os09g0420600 33
  • 44.62 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU11053 33
  • 49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC2H10.02c 33
  • 42.31 (n)
Species where no ortholog for PSMD9 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMD9 Gene

ENSEMBL:
Gene Tree for PSMD9 (if available)
TreeFam:
Gene Tree for PSMD9 (if available)

Paralogs for PSMD9 Gene

Paralogs for PSMD9 Gene

genes like me logo Genes that share paralogs with PSMD9: view

Variants for PSMD9 Gene

Sequence variations from dbSNP and Humsavar for PSMD9 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000063943 -- 121,908,639(+) TAATC(-/A)AATAA intron-variant
rs1000076437 -- 121,913,789(+) CCACC(A/G)TACCC intron-variant
rs1000111435 -- 121,904,263(+) AAATT(A/C)TTTTT intron-variant
rs1000123134 -- 121,901,368(+) TTTAC(A/C)GACAG intron-variant
rs1000132199 -- 121,907,204(+) AGTTG(C/G)GACTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMD9 Gene

Variant ID Type Subtype PubMed ID
esv2661361 CNV deletion 23128226
esv3581938 CNV gain 25503493
esv3630961 CNV loss 21293372
nsv474446 CNV novel sequence insertion 20440878

Variation tolerance for PSMD9 Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.05; 87.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMD9 Gene

Human Gene Mutation Database (HGMD)
PSMD9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMD9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD9 Gene

Disorders for PSMD9 Gene

MalaCards: The human disease database

(11) MalaCards diseases for PSMD9 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
nerve compression syndrome
  • compression neuropathy
hypertensive retinopathy
mental depression
  • depression
carpal tunnel syndrome, familial
  • carpal tunnel syndrome
generalized anxiety disorder
  • anxiety generalized
- elite association - COSMIC cancer census association via MalaCards
Search PSMD9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSMD9

Genetic Association Database (GAD)
PSMD9
Human Genome Epidemiology (HuGE) Navigator
PSMD9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMD9
genes like me logo Genes that share disorders with PSMD9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMD9 Gene

Publications for PSMD9 Gene

  1. cDNA cloning and characterization of a human proteasomal modulator subunit, p27 (PSMD9). (PMID: 9653651) Watanabe TK … Tanaka K (Genomics 1998) 2 3 4 22 60
  2. Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones. (PMID: 19490896) Kaneko T … Murata S (Cell 2009) 3 4 60
  3. Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response. (PMID: 18504423) Wong ML … Licinio J (Molecular psychiatry 2008) 3 45 60
  4. PSMD9 gene variants within NIDDM2 may rarely contribute to type 2 diabetes. (PMID: 17516568) Gragnoli C … Cronsell J (Journal of cellular physiology 2007) 3 45 60
  5. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang AG … Kim NS (Biochemical and biophysical research communications 2006) 3 4 60

Products for PSMD9 Gene