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Aliases for PSMD9 Gene

Aliases for PSMD9 Gene

  • Proteasome 26S Subunit, Non-ATPase 9 2 3
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 9 2 3
  • 26S Proteasome Regulatory Subunit P27 3 4
  • Proteasome 26S Non-ATPase Regulatory Subunit 9 3
  • Homolog Of Rat Bridge 1 3
  • Rpn4 3
  • P27 3

External Ids for PSMD9 Gene

Previous GeneCards Identifiers for PSMD9 Gene

  • GC12P120852
  • GC12M121795
  • GC12P122095
  • GC12P120724
  • GC12P120789
  • GC12P122326
  • GC12P119337
  • GC12P121950

Summaries for PSMD9 Gene

Entrez Gene Summary for PSMD9 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for PSMD9 Gene

PSMD9 (Proteasome 26S Subunit, Non-ATPase 9) is a Protein Coding gene. Diseases associated with PSMD9 include nerve compression syndrome and carpal tunnel syndrome, familial. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include transcription coactivator activity and bHLH transcription factor binding. An important paralog of this gene is ENSG00000256950.

UniProtKB/Swiss-Prot for PSMD9 Gene

  • Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.

Gene Wiki entry for PSMD9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD9 Gene

Genomics for PSMD9 Gene

Regulatory Elements for PSMD9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PSMD9 Gene

Chromosome:
12
Start:
121,888,731 bp from pter
End:
121,918,297 bp from pter
Size:
29,567 bases
Orientation:
Plus strand

Genomic View for PSMD9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSMD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD9 Gene

Proteins for PSMD9 Gene

  • Protein details for PSMD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00233-PSMD9_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 9
    Protein Accession:
    O00233
    Secondary Accessions:
    • B2RD35
    • G3V1Q6
    • Q9BQ42

    Protein attributes for PSMD9 Gene

    Size:
    223 amino acids
    Molecular mass:
    24682 Da
    Quaternary structure:
    • Interacts with PSMC3. Part of a transient complex (modulator) containing PSMD9, PSMC6 and PSMC3 formed during the assembly of the 26S proteasome.

    Alternative splice isoforms for PSMD9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD9 Gene

Proteomics data for PSMD9 Gene at MOPED

Post-translational modifications for PSMD9 Gene

  • Ubiquitination at Lys 117 and Lys 211
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for PSMD9

No data available for DME Specific Peptides for PSMD9 Gene

Domains & Families for PSMD9 Gene

Gene Families for PSMD9 Gene

Protein Domains for PSMD9 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PSMD9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00233

UniProtKB/Swiss-Prot:

PSMD9_HUMAN :
  • Contains 1 PDZ (DHR) domain.
  • Belongs to the proteasome subunit p27 family.
Domain:
  • Contains 1 PDZ (DHR) domain.
Family:
  • Belongs to the proteasome subunit p27 family.
genes like me logo Genes that share domains with PSMD9: view

Function for PSMD9 Gene

Molecular function for PSMD9 Gene

GENATLAS Biochemistry:
multicatalytic proteinase proteasome (prosome,macropain,26S) component,19/22S regulator of proteasome,non ATPase subunit p27 (23-25kDa),with two alternatively spliced isogforms,ubiquitously expressed with highly expresseion in liver and kidney,homolog to S cerevisiae NAS2 gene
UniProtKB/Swiss-Prot Function:
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.

Gene Ontology (GO) - Molecular Function for PSMD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity ISS 10567574
GO:0005515 protein binding IPI 16189514
GO:0043425 bHLH transcription factor binding ISS 10567574
genes like me logo Genes that share ontologies with PSMD9: view

Phenotypes for PSMD9 Gene

genes like me logo Genes that share phenotypes with PSMD9: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD9 Gene

Localization for PSMD9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMD9 Gene COMPARTMENTS Subcellular localization image for PSMD9 gene
Compartment Confidence
cytosol 4
nucleus 4
cytoskeleton 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PSMD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS 10567574
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0005838 proteasome regulatory particle NAS 9653651
genes like me logo Genes that share ontologies with PSMD9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD9 Gene

Pathways & Interactions for PSMD9 Gene

SuperPathways for PSMD9 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin receptor SHC signaling
3 Infectious disease
.53
4 Immune System
5 Downstream signaling events of B Cell Receptor (BCR)
genes like me logo Genes that share pathways with PSMD9: view

Gene Ontology (GO) - Biological Process for PSMD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with PSMD9: view

No data available for SIGNOR curated interactions for PSMD9 Gene

Drugs & Compounds for PSMD9 Gene

(2) Drugs for PSMD9 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 758
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0

(1) Additional Compounds for PSMD9 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
EGCG
989-51-5
genes like me logo Genes that share compounds with PSMD9: view

Transcripts for PSMD9 Gene

Unigene Clusters for PSMD9 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 9:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMD9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: -
SP2: -
SP3:
SP4: - - - - -
SP5: - -

Relevant External Links for PSMD9 Gene

GeneLoc Exon Structure for
PSMD9
ECgene alternative splicing isoforms for
PSMD9

Expression for PSMD9 Gene

mRNA expression in normal human tissues for PSMD9 Gene

Protein differential expression in normal tissues from HIPED for PSMD9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMD9 Gene



SOURCE GeneReport for Unigene cluster for PSMD9 Gene Hs.131151

mRNA Expression by UniProt/SwissProt for PSMD9 Gene

O00233-PSMD9_HUMAN
Tissue specificity: Expressed in all tissues tested, highly expressed in liver and kidney
genes like me logo Genes that share expression patterns with PSMD9: view

Protein tissue co-expression partners for PSMD9 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PSMD9 Gene

Orthologs for PSMD9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMD9 35
  • 88.39 (n)
  • 87.78 (a)
PSMD9 36
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PSMD9 35
  • 88.94 (n)
  • 91.93 (a)
-- 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Psmd9 35
  • 84.08 (n)
  • 84.68 (a)
Psmd9 16
Psmd9 36
  • 85 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia PSMD9 35
  • 99.55 (n)
  • 98.65 (a)
-- 36
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Psmd9 35
  • 83.03 (n)
  • 86.04 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves PSMD9 35
  • 74.06 (n)
  • 71.92 (a)
PSMD9 36
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia psmd9 35
  • 64.5 (n)
  • 67.5 (a)
zebrafish
(Danio rerio)
Actinopterygii psmd9 35
  • 62.12 (n)
  • 59.6 (a)
psmd9 36
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9588 37
  • 41 (a)
CG9588 35
  • 53.33 (n)
  • 42.93 (a)
CG9588 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C44B7.1 37
  • 34 (a)
psmd-9 36
  • 34 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL013C 35
  • 46.46 (n)
  • 35.23 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D14135g 35
  • 45.97 (n)
  • 36.81 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAS2 35
  • 46.06 (n)
  • 39.25 (a)
NAS2 36
  • 34 (a)
OneToMany
NAS2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G57950 35
  • 42.81 (n)
  • 30.46 (a)
rice
(Oryza sativa)
Liliopsida Os09g0420600 35
  • 44.62 (n)
  • 32.81 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU11053 35
  • 49 (n)
  • 39.89 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC2H10.02c 35
  • 42.31 (n)
  • 36.27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for PSMD9:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMD9 Gene

ENSEMBL:
Gene Tree for PSMD9 (if available)
TreeFam:
Gene Tree for PSMD9 (if available)

Paralogs for PSMD9 Gene

Paralogs for PSMD9 Gene

genes like me logo Genes that share paralogs with PSMD9: view

Variants for PSMD9 Gene

Sequence variations from dbSNP and Humsavar for PSMD9 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs14259 - 121,915,890(+) GGGGG(A/C/G)AAAAC reference, missense, nc-transcript-variant
rs482421 -- 121,900,327(-) gcaac(C/T)tcgac intron-variant
rs483416 -- 121,900,207(-) AGACA(C/T)CACAT intron-variant
rs508395 -- 121,914,731(-) gacta(C/T)aggca intron-variant
rs639260 -- 121,915,431(+) GAACA(A/C)TACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMD9 Gene

Variant ID Type Subtype PubMed ID
nsv899568 CNV Gain 21882294
esv2661361 CNV Deletion 23128226

Variation tolerance for PSMD9 Gene

Residual Variation Intolerance Score: 90.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.05; 87.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMD9 Gene

HapMap Linkage Disequilibrium report
PSMD9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD9 Gene

Disorders for PSMD9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PSMD9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nerve compression syndrome
  • peripheral nerve entrapment syndrome
carpal tunnel syndrome, familial
  • carpal tunnel syndrome
- elite association
Search PSMD9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSMD9

Genetic Association Database (GAD)
PSMD9
Human Genome Epidemiology (HuGE) Navigator
PSMD9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMD9
genes like me logo Genes that share disorders with PSMD9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMD9 Gene

Publications for PSMD9 Gene

  1. cDNA cloning and characterization of a human proteasomal modulator subunit, p27 (PSMD9). (PMID: 9653651) Watanabe T.K. … Tanaka K. (Genomics 1998) 2 23 67
  2. Modulations of cell cycle checkpoints during HCV associated disease. (PMID: 19664251) Sarfraz S. … Siddiqui A.A. (BMC Infect. Dis. 2009) 23 67
  3. Expression of Jun activation domain-binding protein 1 and Ser10 phosphorylated p27 protein in human epithelial ovarian carcinoma. (PMID: 19139918) Wang Y. … Shen A. (J. Cancer Res. Clin. Oncol. 2009) 23 67
  4. Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo. (PMID: 19165859) Yang H. … Liu J. (Int. J. Cancer 2009) 23 67
  5. The combination of low cytoplasmic and high nuclear expression of p27 predicts a better prognosis in high-grade astrocytoma. (PMID: 19331209) Hidaka T. … Kurisu K. (Anticancer Res. 2009) 23 67

Products for PSMD9 Gene

Sources for PSMD9 Gene

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