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Aliases for PSMD8 Gene

Aliases for PSMD8 Gene

  • Proteasome 26S Subunit, Non-ATPase 8 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 8 2 3
  • 26S Proteasome Regulatory Subunit RPN12 3 4
  • 26S Proteasome Regulatory Subunit S14 3 4
  • P31 3 4
  • Epididymis Secretory Sperm Binding Protein Li 91n 3
  • 26S Proteasome Regulatory Subunit P31 3
  • HEL-S-91n 3
  • Nin1p 3
  • Rpn12 3
  • HYPF 3
  • HIP6 3
  • S14 3

External Ids for PSMD8 Gene

Previous GeneCards Identifiers for PSMD8 Gene

  • GC19P039479
  • GC19P039256
  • GC19P043541
  • GC19P043558
  • GC19P043559
  • GC19P043560
  • GC19P038865
  • GC19P035312

Summaries for PSMD8 Gene

Entrez Gene Summary for PSMD8 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMD8 Gene

PSMD8 (Proteasome 26S Subunit, Non-ATPase 8) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR.

UniProtKB/Swiss-Prot for PSMD8 Gene

  • Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Necessary for activation of the CDC28 kinase.

Gene Wiki entry for PSMD8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD8 Gene

Genomics for PSMD8 Gene

Regulatory Elements for PSMD8 Gene

Promoters for PSMD8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSMD8 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSMD8 Gene

Chromosome:
19
Start:
38,374,536 bp from pter
End:
38,383,824 bp from pter
Size:
9,289 bases
Orientation:
Plus strand

Genomic View for PSMD8 Gene

Genes around PSMD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD8 Gene

Proteins for PSMD8 Gene

  • Protein details for PSMD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48556-PSMD8_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 8
    Protein Accession:
    P48556
    Secondary Accessions:
    • B4DX18
    • Q6P1L7

    Protein attributes for PSMD8 Gene

    Size:
    350 amino acids
    Molecular mass:
    39612 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC62833.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH01164.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH65006.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA07237.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for PSMD8 Gene

Proteomics data for PSMD8 Gene at MOPED

Post-translational modifications for PSMD8 Gene

  • Ubiquitination at Lys 111, Lys 120, Lys 135, Lys 138, Lys 218, Lys 227, Lys 297, and Lys 337
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for PSMD8 Gene

Domains & Families for PSMD8 Gene

Gene Families for PSMD8 Gene

Protein Domains for PSMD8 Gene

Suggested Antigen Peptide Sequences for PSMD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P48556

UniProtKB/Swiss-Prot:

PSMD8_HUMAN :
  • Belongs to the proteasome subunit S14 family.
Family:
  • Belongs to the proteasome subunit S14 family.
genes like me logo Genes that share domains with PSMD8: view

Function for PSMD8 Gene

Molecular function for PSMD8 Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Necessary for activation of the CDC28 kinase.
genes like me logo Genes that share phenotypes with PSMD8: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD8 Gene

Localization for PSMD8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMD8 Gene COMPARTMENTS Subcellular localization image for PSMD8 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 2
golgi apparatus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PSMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PSMD8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD8 Gene

Pathways & Interactions for PSMD8 Gene

SuperPathways for PSMD8 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin-3, 5 and GM-CSF signaling
3 Infectious disease
.48
4 Immune System
5 Cell Cycle, Mitotic
.61
genes like me logo Genes that share pathways with PSMD8: view

Gene Ontology (GO) - Biological Process for PSMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSMD8: view

No data available for SIGNOR curated interactions for PSMD8 Gene

Drugs & Compounds for PSMD8 Gene

(2) Drugs for PSMD8 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 769
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMD8: view

Transcripts for PSMD8 Gene

Unigene Clusters for PSMD8 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: -
SP6: - - -
SP7:

Relevant External Links for PSMD8 Gene

GeneLoc Exon Structure for
PSMD8
ECgene alternative splicing isoforms for
PSMD8

Expression for PSMD8 Gene

mRNA expression in normal human tissues for PSMD8 Gene

mRNA differential expression in normal tissues according to GTEx for PSMD8 Gene

This gene is overexpressed in Muscle - Skeletal (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PSMD8 Gene



SOURCE GeneReport for Unigene cluster for PSMD8 Gene Hs.78466

genes like me logo Genes that share expression patterns with PSMD8: view

Protein tissue co-expression partners for PSMD8 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMD8 Gene

Orthologs for PSMD8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMD8 35
  • 99.62 (n)
  • 100 (a)
PSMD8 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSMD8 36
  • 97 (a)
OneToOne
PSMD8 35
  • 91.75 (n)
  • 96.86 (a)
dog
(Canis familiaris)
Mammalia PSMD8 35
  • 90.19 (n)
  • 92.29 (a)
PSMD8 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmd8 36
  • 89 (a)
OneToOne
Psmd8 35
  • 84.95 (n)
  • 89.71 (a)
Psmd8 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PSMD8 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmd8 35
  • 86.38 (n)
  • 90.29 (a)
lizard
(Anolis carolinensis)
Reptilia PSMD8 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3601 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9469 35
zebrafish
(Danio rerio)
Actinopterygii psmd8 36
  • 83 (a)
OneToOne
psmd8 35
  • 72.81 (n)
  • 83.08 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002606 35
  • 62.98 (n)
  • 53.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11552 37
  • 41 (a)
Rpn12 37
  • 50 (a)
Rpn12 36
  • 49 (a)
OneToMany
Rpn12R 36
  • 41 (a)
OneToMany
Rpn12 35
  • 59.92 (n)
  • 50.58 (a)
worm
(Caenorhabditis elegans)
Secernentea rpn-12 35
  • 48.1 (n)
  • 39.02 (a)
rpn-12 36
  • 36 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR278W 35
  • 50.14 (n)
  • 39.74 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN12 35
  • 46.03 (n)
  • 34.73 (a)
RPN12 36
  • 30 (a)
OneToOne
RPN12 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D11374g 35
  • 46.02 (n)
  • 38.05 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RPN12a 35
  • 49.55 (n)
  • 39.38 (a)
rice
(Oryza sativa)
Liliopsida Os07g0435100 35
  • 49.55 (n)
  • 39.38 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU10067 35
  • 50.43 (n)
  • 37.61 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpn12 35
  • 45.94 (n)
  • 41.29 (a)
Species with no ortholog for PSMD8:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PSMD8 Gene

ENSEMBL:
Gene Tree for PSMD8 (if available)
TreeFam:
Gene Tree for PSMD8 (if available)

Paralogs for PSMD8 Gene

(3) SIMAP similar genes for PSMD8 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for PSMD8 Gene

genes like me logo Genes that share paralogs with PSMD8: view

No data available for Paralogs for PSMD8 Gene

Variants for PSMD8 Gene

Sequence variations from dbSNP and Humsavar for PSMD8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1804245 -- 38,379,297(+) CTCTT(C/T)CTGCT reference, synonymous-codon
rs2072350 -- 38,380,542(+) CAGTT(C/T)GGGCA intron-variant
rs2302227 -- 38,376,481(+) AACTG(A/G)GGGGG intron-variant
rs2302228 -- 38,376,498(+) CATGG(A/C/G)AGCTC intron-variant
rs5828008 -- 38,374,241(+) TTGGG(-/A)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PSMD8 Gene

Variant ID Type Subtype PubMed ID
nsv833822 CNV Loss 17160897
nsv911658 CNV Loss 21882294
nsv470140 CNV Gain 18288195
nsv911659 CNV Loss 21882294
nsv911660 CNV Gain 21882294
nsv833823 CNV Loss 17160897
dgv3857n71 CNV Loss 21882294

Variation tolerance for PSMD8 Gene

Gene Damage Index Score: 1.56; 30.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMD8 Gene

HapMap Linkage Disequilibrium report
PSMD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD8 Gene

Disorders for PSMD8 Gene

Relevant External Links for PSMD8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMD8

No disorders were found for PSMD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMD8 Gene

Publications for PSMD8 Gene

  1. Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae. (PMID: 7621825) Kominami K. … Toh-e A. (EMBO J. 1995) 2 3 4 67
  2. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for PSMD8 Gene

Sources for PSMD8 Gene

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