Aliases for PSMD8 Gene
- Proteasome 26S Subunit, Non-ATPase 8 2 3 5
- Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 8 2 3
- 26S Proteasome Regulatory Subunit RPN12 3 4
- 26S Proteasome Regulatory Subunit S14 3 4
- P31 3 4
- Epididymis Secretory Sperm Binding Protein Li 91n 3
- 26S Proteasome Non-ATPase Regulatory Subunit 8 3
- 26S Proteasome Regulatory Subunit P31 3
Previous GeneCards Identifiers for PSMD8 Gene
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSMD8 Gene
PSMD8 (Proteasome 26S Subunit, Non-ATPase 8) is a Protein Coding gene. Among its related pathways are RET signaling and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.
UniProtKB/Swiss-Prot for PSMD8 Gene
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.