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Aliases for PSMD8 Gene

Aliases for PSMD8 Gene

  • Proteasome 26S Subunit, Non-ATPase 8 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 8 2 3
  • 26S Proteasome Regulatory Subunit RPN12 3 4
  • 26S Proteasome Regulatory Subunit S14 3 4
  • P31 3 4
  • Epididymis Secretory Sperm Binding Protein Li 91n 3
  • 26S Proteasome Non-ATPase Regulatory Subunit 8 3
  • 26S Proteasome Regulatory Subunit P31 3
  • HEL-S-91n 3
  • Nin1p 3
  • Rpn12 3
  • HYPF 3
  • HIP6 3
  • S14 3

External Ids for PSMD8 Gene

Previous GeneCards Identifiers for PSMD8 Gene

  • GC19P039479
  • GC19P039256
  • GC19P043541
  • GC19P043558
  • GC19P043559
  • GC19P043560
  • GC19P038865
  • GC19P035312

Summaries for PSMD8 Gene

Entrez Gene Summary for PSMD8 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMD8 Gene

PSMD8 (Proteasome 26S Subunit, Non-ATPase 8) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and RET signaling.

UniProtKB/Swiss-Prot for PSMD8 Gene

  • Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

Gene Wiki entry for PSMD8 Gene

Additional gene information for PSMD8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD8 Gene

Genomics for PSMD8 Gene

Regulatory Elements for PSMD8 Gene

Enhancers for PSMD8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H038417 1.2 Ensembl ENCODE 11.3 +43.5 43477 1 HDGF PKNOX1 ATF1 GLIS2 ELK1 KLF7 ATF7 SP3 NCOA1 GLIS1 PSMD8 ZFP30 CATSPERG ZNF571 FBXO17 GC19P038425 FAM98C
GH19H038312 2 FANTOM5 Ensembl ENCODE dbSUPER 4.7 -56.9 -56916 9 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CBX5 C19orf33 HNRNPL CATSPERG ZNF573 ENSG00000266963 ZNF527 PAK4 ENSG00000268756 SPINT2 ZNF571
GH19H038338 0.8 ENCODE 11.5 -35.4 -35417 0 HDAC1 PKNOX1 TAL1 ZNF324 TCF12 ZNF791 GATA3 CTBP1 ZNF366 NCOR1 C19orf33 YIF1B ZNF571 ZNF573 HNRNPL ZNF527 PSMD8 ACTN4 CATSPERG PPP1R14A
GH19H038373 1.2 ENCODE 6.2 +0.9 857 3 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 HNRNPL ZFP30 ZNF571 ZNF573 ZNF781 ZNF540 ZNF793 ENSG00000267152 ZNF607 ZNF569
GH19H038361 1 ENCODE 5.4 -12.2 -12185 1 PKNOX1 ATF1 ZNF133 SIN3A ZNF2 ZBTB7B ZNF121 GLIS2 ELK1 KLF7 C19orf33 CATSPERG ENSG00000266963 ENSG00000269445 ENSG00000267375 ENSG00000269172 SPRED3 GGN FAM98C DPF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSMD8 on UCSC Golden Path with GeneCards custom track

Promoters for PSMD8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109274 464 1601 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC ZNF610 GLIS1

Genomic Location for PSMD8 Gene

Chromosome:
19
Start:
38,374,536 bp from pter
End:
38,383,824 bp from pter
Size:
9,289 bases
Orientation:
Plus strand

Genomic View for PSMD8 Gene

Genes around PSMD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD8 Gene

Proteins for PSMD8 Gene

  • Protein details for PSMD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48556-PSMD8_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 8
    Protein Accession:
    P48556
    Secondary Accessions:
    • B4DX18
    • Q6P1L7

    Protein attributes for PSMD8 Gene

    Size:
    350 amino acids
    Molecular mass:
    39612 Da
    Quaternary structure:
    • Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD8, a base containing 6 ATPases and few additional components.
    SequenceCaution:
    • Sequence=AAC62833.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH01164.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH65006.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA07237.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PSMD8 Gene

neXtProt entry for PSMD8 Gene

Post-translational modifications for PSMD8 Gene

  • Ubiquitination at Lys111, Lys120, isoforms=135, Lys138, Lys218, Lys227, isoforms=297, and isoforms=337
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSMD8 Gene

Domains & Families for PSMD8 Gene

Gene Families for PSMD8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PSMD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P48556

UniProtKB/Swiss-Prot:

PSMD8_HUMAN :
  • Belongs to the proteasome subunit S14 family.
Family:
  • Belongs to the proteasome subunit S14 family.
genes like me logo Genes that share domains with PSMD8: view

Function for PSMD8 Gene

Molecular function for PSMD8 Gene

UniProtKB/Swiss-Prot Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

Phenotypes From GWAS Catalog for PSMD8 Gene

genes like me logo Genes that share phenotypes with PSMD8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PSMD8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD8 Gene

Localization for PSMD8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMD8 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 2
plasma membrane 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS,IDA 17323924
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS,IBA --
GO:0005838 proteasome regulatory particle TAS 7621825
genes like me logo Genes that share ontologies with PSMD8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD8 Gene

Pathways & Interactions for PSMD8 Gene

SuperPathways for PSMD8 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 HIV Life Cycle
.45
4 Class I MHC mediated antigen processing and presentation
5 Antigen processing-Cross presentation
genes like me logo Genes that share pathways with PSMD8: view

Gene Ontology (GO) - Biological Process for PSMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PSMD8: view

No data available for SIGNOR curated interactions for PSMD8 Gene

Drugs & Compounds for PSMD8 Gene

(2) Drugs for PSMD8 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 814
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMD8: view

Transcripts for PSMD8 Gene

Unigene Clusters for PSMD8 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PSMD8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: -
SP6: - - -
SP7:

Relevant External Links for PSMD8 Gene

GeneLoc Exon Structure for
PSMD8
ECgene alternative splicing isoforms for
PSMD8

Expression for PSMD8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMD8 Gene

mRNA differential expression in normal tissues according to GTEx for PSMD8 Gene

This gene is overexpressed in Muscle - Skeletal (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PSMD8 Gene



Protein tissue co-expression partners for PSMD8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMD8 Gene:

PSMD8

SOURCE GeneReport for Unigene cluster for PSMD8 Gene:

Hs.78466

Evidence on tissue expression from TISSUES for PSMD8 Gene

  • Skin(4.7)
  • Muscle(4.5)
  • Blood(4.2)
  • Nervous system(4)
  • Lung(3.8)
  • Intestine(3.7)
  • Pancreas(2.8)
  • Liver(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with PSMD8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMD8 Gene

Orthologs for PSMD8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMD8 33 34
  • 99.62 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 92 (a)
OneToMany
-- 34
  • 91 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PSMD8 33 34
  • 91.75 (n)
dog
(Canis familiaris)
Mammalia PSMD8 33 34
  • 90.19 (n)
rat
(Rattus norvegicus)
Mammalia Psmd8 33
  • 86.38 (n)
mouse
(Mus musculus)
Mammalia Psmd8 33 16 34
  • 84.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PSMD8 34
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMD8 34
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3601 33
zebrafish
(Danio rerio)
Actinopterygii psmd8 33 34
  • 72.81 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9469 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002606 33
  • 62.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rpn12 35 33 34
  • 59.92 (n)
CG11552 35
  • 41 (a)
Rpn12R 34
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rpn-12 34 33
  • 48.1 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR278W 33
  • 50.14 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN12 33 34 36
  • 46.03 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D11374g 33
  • 46.02 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RPN12a 33
  • 49.55 (n)
rice
(Oryza sativa)
Liliopsida Os07g0435100 33
  • 49.55 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU10067 33
  • 50.43 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpn12 33
  • 45.94 (n)
Species where no ortholog for PSMD8 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PSMD8 Gene

ENSEMBL:
Gene Tree for PSMD8 (if available)
TreeFam:
Gene Tree for PSMD8 (if available)

Paralogs for PSMD8 Gene

(3) SIMAP similar genes for PSMD8 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for PSMD8 Gene

genes like me logo Genes that share paralogs with PSMD8: view

No data available for Paralogs for PSMD8 Gene

Variants for PSMD8 Gene

Sequence variations from dbSNP and Humsavar for PSMD8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000158263 -- 38,375,171(+) CGTTG(A/G)TGGTC intron-variant
rs1000594222 -- 38,376,479(+) CCAAC(G/T)GGGGG intron-variant
rs1000758919 -- 38,376,681(+) GTGGG(A/G)CTGCC intron-variant
rs1001307795 -- 38,377,163(+) TTTCC(C/T)TGTTA intron-variant
rs1001683632 -- 38,384,158(+) CAGAA(C/T)TGGGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PSMD8 Gene

Variant ID Type Subtype PubMed ID
nsv1064275 CNV loss 25217958
nsv470140 CNV gain 18288195
nsv833822 CNV loss 17160897
nsv833823 CNV loss 17160897
nsv953296 CNV deletion 24416366

Variation tolerance for PSMD8 Gene

Gene Damage Index Score: 1.56; 30.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMD8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD8 Gene

Disorders for PSMD8 Gene

Relevant External Links for PSMD8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMD8

No disorders were found for PSMD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMD8 Gene

Publications for PSMD8 Gene

  1. Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae. (PMID: 7621825) Kominami K … Shimizu Y (The EMBO journal 1995) 2 3 4 60
  2. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4 60
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for PSMD8 Gene

Sources for PSMD8 Gene