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Aliases for PSMD7 Gene

Aliases for PSMD7 Gene

  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 7 2 3
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 7 (Mov34 Homolog) 2 3
  • 26S Proteasome Regulatory Subunit S12 3 4
  • Proteasome Subunit P40 3 4
  • Mov34 Homolog 2 3
  • MOV34 3 6
  • 26S Proteasome Non-ATPase Regulatory Subunit 7 3
  • Moloney Leukemia Virus-34 Proviral Integration 3
  • 26S Proteasome Regulatory Subunit Rpn8 3
  • 26S Proteasome Regulatory Subunit RPN8 4
  • Mov34 Protein Homolog 4
  • MOV34L 4
  • Rpn8 3
  • P40 3
  • S12 3

External Ids for PSMD7 Gene

Summaries for PSMD7 Gene

Entrez Gene Summary for PSMD7 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMD7 Gene

PSMD7 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 7) is a Protein Coding gene. Diseases associated with PSMD7 include hereditary renal cell carcinoma and hiv-1. Among its related pathways are Signaling by GPCR and Downstream Signaling Events Of B Cell Receptor (BCR). An important paralog of this gene is COPS6.

UniProtKB/Swiss-Prot for PSMD7 Gene

  • Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins

Gene Wiki entry for PSMD7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD7 Gene

Genomics for PSMD7 Gene

Genomic Location for PSMD7 Gene

Start:
74,296,775 bp from pter
End:
74,306,288 bp from pter
Size:
9,514 bases
Orientation:
Plus strand

Genomic View for PSMD7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSMD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD7 Gene

Regulatory Elements for PSMD7 Gene

Proteins for PSMD7 Gene

  • Protein details for PSMD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51665-PSMD7_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 7
    Protein Accession:
    P51665
    Secondary Accessions:
    • D3DWS9
    • Q6PKI2
    • Q96E97

    Protein attributes for PSMD7 Gene

    Size:
    324 amino acids
    Molecular mass:
    37025 Da
    Quaternary structure:
    • Homodimer. Interacts with TRIM5.
    Miscellaneous:
    • Does not bind a metal ion
    SequenceCaution:
    • Sequence=AAH00338.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PSMD7 Gene

neXtProt entry for PSMD7 Gene

Proteomics data for PSMD7 Gene at MOPED

Post-translational modifications for PSMD7 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys45, Lys100, Lys103, Lys113, Lys180, Lys199, Lys204, and Lys279

Other Protein References for PSMD7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PSMD7 Gene

Domains for PSMD7 Gene

Gene Families for PSMD7 Gene

HGNC:
  • PSM :Proteasome (prosome, macropain) subunits

Protein Domains for PSMD7 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

PSMD7_HUMAN
Domain:
  • Contains 1 MPN (JAB/Mov34) domain.:
    • P51665
Family:
  • Belongs to the peptidase M67A family.:
    • P51665
genes like me logo Genes that share domains with PSMD7: view

Function for PSMD7 Gene

Molecular function for PSMD7 Gene

GENATLAS Biochemistry: multicatalytic proteinase complex (prosome,macropain,26S),19/22S regulator of proteasome,non -ATPase subunit p40,Mov34 homolog,interferon gamma inducible
UniProtKB/Swiss-Prot Function: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins

Gene Ontology (GO) - Molecular Function for PSMD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19615732
GO:0042803 protein homodimerization activity IDA 17559875
genes like me logo Genes that share ontologies with PSMD7: view

Phenotypes for PSMD7 Gene

genes like me logo Genes that share phenotypes with PSMD7: view

miRNA for PSMD7 Gene

miRTarBase miRNAs that target PSMD7

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PSMD7 Gene

Localization for PSMD7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMD7 Gene COMPARTMENTS Subcellular localization image for PSMD7 gene
Compartment Confidence
cytosol 4
nucleus 4
endoplasmic reticulum 2
plasma membrane 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PSMD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 17323924
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005838 proteasome regulatory particle IEA --
genes like me logo Genes that share ontologies with PSMD7: view

Pathways for PSMD7 Gene

SuperPathways for PSMD7 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.38
2 Chks in Checkpoint Regulation
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.62
5 Mitotic Metaphase and Anaphase
genes like me logo Genes that share pathways with PSMD7: view

Gene Ontology (GO) - Biological Process for PSMD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSMD7: view

Compounds for PSMD7 Gene

(16) ApexBio Compounds for PSMD7 Gene

Compound Action Cas Number
Aclacinomycin A Specific inhibitor of the 20S proteasome chymotrypsin-like activity [57576-44-0]
AM 114 Boronic-chalcone derived proteasome inhibitor with anticancer activity [856849-35-9]
Bortezomib (PS-341, LDP-3411) Cell-permeable proteasome inhibitor [179324-69-7]
Carfilzomib (PR-171) Proteasome inhibitor, analog of epoxomicin [868540-17-4]
CEP-18770 Orally active inhibitor of the chymotrypsin-like activity of proteasome [847499-27-8]
Dihydroeponemycin Proteasome inhibitor and antitumor reagent [126463-64-7]
Epoxomicin Irreversible proteasome inhibitor [134381-21-8]
Gliotoxin Non-competitively inhibits chymotrypsin-like activity of 20S proteasome [67-99-2]
MG-115 Reversible proteasome inhibitor
MG-132 Proteasome and calpain inhibitor. [133407-82-6]
MG-262 Boronic acid-based, reversible, cell-permeable proteasome inhibitor
MLN2238 Potent reversible and specific beta5 site of the 20S proteasome inhibitor [1072833-77-2]
MLN9708 Inhibits chymotrypsin-like proteasome activity [1201902-80-8]
ONX-0914 (PR-957) Immunoproteasome inhibitor [960374-59-8]
Oprozomib (ONX-0912) Orally bioavailable inhibitor for CT-L activity of 20S proteasome beta5/LMP7 [935888-69-0]
PSI Inhibits chymotrypsin-like proteasome activity [158442-41-2]
genes like me logo Genes that share compounds with PSMD7: view

Transcripts for PSMD7 Gene

Unigene Clusters for PSMD7 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - -
SP2: - - - -
SP3: - -
SP4: -
SP5: -

Relevant External Links for PSMD7 Gene

GeneLoc Exon Structure for
PSMD7
ECgene alternative splicing isoforms for
PSMD7

Expression for PSMD7 Gene

mRNA expression in normal human tissues for PSMD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMD7 Gene

SOURCE GeneReport for Unigene cluster for PSMD7 Gene Hs.440604

genes like me logo Genes that share expressions with PSMD7: view

Orthologs for PSMD7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMD7 36
  • 99.59 (n)
  • 100 (a)
PSMD7 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSMD7 36
  • 93.04 (n)
  • 99.32 (a)
PSMD7 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMD7 36
  • 91.87 (n)
  • 98.46 (a)
PSMD7 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmd7 36
  • 90.29 (n)
  • 99.3 (a)
Psmd7 16
Psmd7 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PSMD7 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMD7 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmd7 36
  • 90.53 (n)
  • 98.6 (a)
chicken
(Gallus gallus)
Aves PSMD7 36
  • 86.33 (n)
  • 98.08 (a)
PSMD7 37
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMD7 37
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23830 36
tropical clawed frog
(Silurana tropicalis)
Amphibia psmd7 36
  • 80.7 (n)
  • 97.19 (a)
Str.6354 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2398 36
zebrafish
(Danio rerio)
Actinopterygii psmd7 36
  • 81.87 (n)
  • 96.84 (a)
psmd7 37
  • 92 (a)
OneToOne
wufi03c01 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012135 36
  • 74.04 (n)
  • 82.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mov34 36
  • 72.75 (n)
  • 82.46 (a)
Mov34 37
  • 74 (a)
OneToOne
Mov34 38
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea rpn-8 36
  • 67.26 (n)
  • 70.21 (a)
rpn-8 37
  • 59 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL116W 36
  • 60.02 (n)
  • 55.07 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN8 36
  • 56.28 (n)
  • 54.71 (a)
RPN8 37
  • 47 (a)
OneToMany
RPN8 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C09526g 36
  • 53.74 (n)
  • 52.17 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1252 36
soybean
(Glycine max)
eudicotyledons Gma.5368 36
thale cress
(Arabidopsis thaliana)
eudicotyledons RPN8A 36
  • 63.08 (n)
  • 62.37 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3245 36
corn
(Zea mays)
Liliopsida Zm.477 36
rice
(Oryza sativa)
Liliopsida Os.5973 36
Os04g0661900 36
  • 60.96 (n)
  • 60.36 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2207 36
bread mold
(Neurospora crassa)
Ascomycetes NCU01547 36
  • 60.71 (n)
  • 62.86 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpn8 36
  • 58.09 (n)
  • 56.52 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4256 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 70 (a)
OneToOne
Species with no ortholog for PSMD7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMD7 Gene

ENSEMBL:
Gene Tree for PSMD7 (if available)
TreeFam:
Gene Tree for PSMD7 (if available)

Paralogs for PSMD7 Gene

Paralogs for PSMD7 Gene

Pseudogenes.org Pseudogenes for PSMD7 Gene

genes like me logo Genes that share paralogs with PSMD7: view

Variants for PSMD7 Gene

Sequence variations from dbSNP and Humsavar for PSMD7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs7603 -- 74,305,702(+) tgatg(C/T)aaaga missense, reference
rs15263 -- 74,305,648(+) gagca(A/T)aaagg reference, missense
rs889641 -- 74,299,482(+) TCAAG(C/T)AGTCC intron-variant
rs1057012 -- 74,306,189(-) CATGG(G/T)GTGGT utr-variant-3-prime
rs1057013 -- 74,306,166(-) GTTCA(A/G)AAGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PSMD7 Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
dgv2910n71 CNV Gain 21882294
nsv833276 CNV Loss 17160897
dgv900e1 CNV Complex 17122850
dgv901e1 CNV Complex 17122850
nsv833277 CNV Loss 17160897
esv22159 CNV Gain+Loss 19812545
nsv827736 CNV Gain 20364138

Relevant External Links for PSMD7 Gene

HapMap Linkage Disequilibrium report
PSMD7
Human Gene Mutation Database (HGMD)
PSMD7

Disorders for PSMD7 Gene

(1) University of Copenhagen DISEASES for PSMD7 Gene

Relevant External Links for PSMD7

Genetic Association Database (GAD)
PSMD7
Human Genome Epidemiology (HuGE) Navigator
PSMD7
genes like me logo Genes that share disorders with PSMD7: view

No data available for UniProtKB/Swiss-Prot for PSMD7 Gene

Publications for PSMD7 Gene

  1. cDNA cloning of p40, a regulatory subunit of the human 26S proteasome, and a homolog of the Mov-34 gene product. (PMID: 7755639) Tsurumi C. … Tanaka K. (Biochem. Biophys. Res. Commun. 1995) 2 3 4 23
  2. The crystal structure of the human Mov34 MPN domain reveals a metal- free dimer. (PMID: 17559875) Sanches M. … Guimaraes B.G. (J. Mol. Biol. 2007) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X. … Huang L. (Biochemistry 2007) 3 4
  5. TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions. (PMID: 22078707) Lukic Z. … Campbell E.M. (Retrovirology 2011) 3 4

Products for PSMD7 Gene

  • Addgene plasmids for PSMD7

Sources for PSMD7 Gene

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