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Aliases for PSMD7 Gene

Aliases for PSMD7 Gene

  • Proteasome 26S Subunit, Non-ATPase 7 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 7 (Mov34 Homolog) 2 3
  • 26S Proteasome Regulatory Subunit S12 3 4
  • Proteasome Subunit P40 3 4
  • Mov34 Homolog 2 3
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 7 2
  • Moloney Leukemia Virus-34 Proviral Integration 3
  • 26S Proteasome Regulatory Subunit Rpn8 3
  • 26S Proteasome Regulatory Subunit RPN8 4
  • Mov34 Protein Homolog 4
  • MOV34L 4
  • MOV34 3
  • Rpn8 3
  • P40 3
  • S12 3

External Ids for PSMD7 Gene

Previous GeneCards Identifiers for PSMD7 Gene

  • GC16P065261
  • GC16P075291
  • GC16P074069
  • GC16P074110
  • GC16P072888
  • GC16P074330
  • GC16P060097

Summaries for PSMD7 Gene

Entrez Gene Summary for PSMD7 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMD7 Gene

PSMD7 (Proteasome 26S Subunit, Non-ATPase 7) is a Protein Coding gene. Diseases associated with PSMD7 include hereditary renal cell carcinoma. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is EIF3FP2.

UniProtKB/Swiss-Prot for PSMD7 Gene

  • Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

Gene Wiki entry for PSMD7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD7 Gene

Genomics for PSMD7 Gene

Regulatory Elements for PSMD7 Gene

Promoters for PSMD7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSMD7 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSMD7 Gene

Chromosome:
16
Start:
74,296,775 bp from pter
End:
74,306,288 bp from pter
Size:
9,514 bases
Orientation:
Plus strand

Genomic View for PSMD7 Gene

Genes around PSMD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD7 Gene

Proteins for PSMD7 Gene

  • Protein details for PSMD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51665-PSMD7_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 7
    Protein Accession:
    P51665
    Secondary Accessions:
    • D3DWS9
    • Q6PKI2
    • Q96E97

    Protein attributes for PSMD7 Gene

    Size:
    324 amino acids
    Molecular mass:
    37025 Da
    Quaternary structure:
    • Homodimer. Interacts with TRIM5.
    Miscellaneous:
    • Does not bind a metal ion.
    SequenceCaution:
    • Sequence=AAH00338.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PSMD7 Gene

neXtProt entry for PSMD7 Gene

Proteomics data for PSMD7 Gene at MOPED

Post-translational modifications for PSMD7 Gene

  • Ubiquitination at Lys 45, Lys 100, Lys 103, Lys 113, Lys 180, Lys 199, Lys 204, and Lys 279
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMD7 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for PSMD7

No data available for DME Specific Peptides for PSMD7 Gene

Domains & Families for PSMD7 Gene

Gene Families for PSMD7 Gene

Protein Domains for PSMD7 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PSMD7 Gene

Graphical View of Domain Structure for InterPro Entry

P51665

UniProtKB/Swiss-Prot:

PSMD7_HUMAN :
  • Contains 1 MPN (JAB/Mov34) domain.
  • Belongs to the peptidase M67A family.
Domain:
  • Contains 1 MPN (JAB/Mov34) domain.
Family:
  • Belongs to the peptidase M67A family.
genes like me logo Genes that share domains with PSMD7: view

Function for PSMD7 Gene

Molecular function for PSMD7 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (prosome,macropain,26S),19/22S regulator of proteasome,non -ATPase subunit p40,Mov34 homolog,interferon gamma inducible
UniProtKB/Swiss-Prot Function:
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
genes like me logo Genes that share phenotypes with PSMD7: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD7 Gene

Localization for PSMD7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMD7 Gene COMPARTMENTS Subcellular localization image for PSMD7 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
endoplasmic reticulum 2
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PSMD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with PSMD7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD7 Gene

Pathways & Interactions for PSMD7 Gene

SuperPathways for PSMD7 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin-3, 5 and GM-CSF signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.48
5 Immune System
genes like me logo Genes that share pathways with PSMD7: view

Gene Ontology (GO) - Biological Process for PSMD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSMD7: view

No data available for SIGNOR curated interactions for PSMD7 Gene

Drugs & Compounds for PSMD7 Gene

(2) Drugs for PSMD7 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 769
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMD7: view

Transcripts for PSMD7 Gene

Unigene Clusters for PSMD7 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - -
SP2: - - - -
SP3: - -
SP4: -
SP5: -

Relevant External Links for PSMD7 Gene

GeneLoc Exon Structure for
PSMD7
ECgene alternative splicing isoforms for
PSMD7

Expression for PSMD7 Gene

mRNA expression in normal human tissues for PSMD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMD7 Gene

This gene is overexpressed in Breast (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMD7 Gene



SOURCE GeneReport for Unigene cluster for PSMD7 Gene Hs.440604

genes like me logo Genes that share expression patterns with PSMD7: view

Protein tissue co-expression partners for PSMD7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMD7 Gene

Orthologs for PSMD7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMD7 36
  • 100 (a)
OneToOne
PSMD7 35
  • 99.59 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia PSMD7 36
  • 98 (a)
OneToOne
PSMD7 35
  • 93.04 (n)
  • 99.32 (a)
dog
(Canis familiaris)
Mammalia PSMD7 35
  • 91.87 (n)
  • 98.46 (a)
PSMD7 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmd7 36
  • 98 (a)
OneToOne
Psmd7 16
Psmd7 35
  • 90.29 (n)
  • 99.3 (a)
oppossum
(Monodelphis domestica)
Mammalia PSMD7 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMD7 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmd7 35
  • 90.53 (n)
  • 98.6 (a)
chicken
(Gallus gallus)
Aves PSMD7 35
  • 86.33 (n)
  • 98.08 (a)
PSMD7 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMD7 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23830 35
tropical clawed frog
(Silurana tropicalis)
Amphibia psmd7 35
  • 80.7 (n)
  • 97.19 (a)
Str.6354 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2398 35
zebrafish
(Danio rerio)
Actinopterygii psmd7 36
  • 92 (a)
OneToOne
psmd7 35
  • 81.87 (n)
  • 96.84 (a)
wufi03c01 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012135 35
  • 74.04 (n)
  • 82.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mov34 35
  • 72.75 (n)
  • 82.46 (a)
Mov34 37
  • 72 (a)
Mov34 36
  • 74 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpn-8 35
  • 67.26 (n)
  • 70.21 (a)
rpn-8 36
  • 59 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL116W 35
  • 60.02 (n)
  • 55.07 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN8 36
  • 47 (a)
OneToMany
RPN8 38
RPN8 35
  • 56.28 (n)
  • 54.71 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C09526g 35
  • 53.74 (n)
  • 52.17 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1252 35
soybean
(Glycine max)
eudicotyledons Gma.5368 35
thale cress
(Arabidopsis thaliana)
eudicotyledons RPN8A 35
  • 63.08 (n)
  • 62.37 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3245 35
corn
(Zea mays)
Liliopsida Zm.477 35
rice
(Oryza sativa)
Liliopsida Os.5973 35
Os04g0661900 35
  • 60.96 (n)
  • 60.36 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2207 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01547 35
  • 60.71 (n)
  • 62.86 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpn8 35
  • 58.09 (n)
  • 56.52 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4256 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
OneToOne
Species with no ortholog for PSMD7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMD7 Gene

ENSEMBL:
Gene Tree for PSMD7 (if available)
TreeFam:
Gene Tree for PSMD7 (if available)

Paralogs for PSMD7 Gene

Paralogs for PSMD7 Gene

Pseudogenes.org Pseudogenes for PSMD7 Gene

genes like me logo Genes that share paralogs with PSMD7: view

Variants for PSMD7 Gene

Sequence variations from dbSNP and Humsavar for PSMD7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs15263 -- 74,305,648(+) gagca(A/T)aaagg reference, missense
rs1057012 -- 74,306,189(-) CATGG(G/T)GTGGT utr-variant-3-prime
rs1057013 -- 74,306,166(-) GTTCA(A/G)AAGGG utr-variant-3-prime
rs889641 -- 74,299,482(+) TCAAG(C/T)AGTCC intron-variant
rs3208888 -- 74,305,715(-) TTTTT(C/T)TTTTC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PSMD7 Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
dgv2910n71 CNV Gain 21882294
nsv833276 CNV Loss 17160897
dgv900e1 CNV Complex 17122850
dgv901e1 CNV Complex 17122850
nsv833277 CNV Loss 17160897
esv22159 CNV Gain+Loss 19812545
nsv827736 CNV Gain 20364138

Variation tolerance for PSMD7 Gene

Residual Variation Intolerance Score: 20.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMD7 Gene

HapMap Linkage Disequilibrium report
PSMD7
Human Gene Mutation Database (HGMD)
PSMD7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD7 Gene

Disorders for PSMD7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSMD7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hereditary renal cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search PSMD7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSMD7

Genetic Association Database (GAD)
PSMD7
Human Genome Epidemiology (HuGE) Navigator
PSMD7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMD7
genes like me logo Genes that share disorders with PSMD7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMD7 Gene

Publications for PSMD7 Gene

  1. cDNA cloning of p40, a regulatory subunit of the human 26S proteasome, and a homolog of the Mov-34 gene product. (PMID: 7755639) Tsurumi C. … Tanaka K. (Biochem. Biophys. Res. Commun. 1995) 2 3 4 23 67
  2. The crystal structure of the human Mov34 MPN domain reveals a metal- free dimer. (PMID: 17559875) Sanches M. … Guimaraes B.G. (J. Mol. Biol. 2007) 3 23
  3. Post-translationally modified S12, absent in transformed breast epithelial cells, is not associated with the 26S proteasome and is induced by proteasome inhibitor. (PMID: 15221960) Thompson H.G. … Brody J.P. (Int. J. Cancer 2004) 3 23
  4. HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle. (PMID: 9520381) Mahalingam S. … Weiner D.B. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 23
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for PSMD7 Gene

Sources for PSMD7 Gene

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