Aliases for PSMD7 Gene
- Proteasome 26S Subunit, Non-ATPase 7 2 3 5
- Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 7 (Mov34 Homolog) 2 3
- 26S Proteasome Regulatory Subunit S12 3 4
- Proteasome Subunit P40 3 4
- Mov34 Homolog 2 3
- Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 7 2
- Moloney Leukemia Virus-34 Proviral Integration 3
- 26S Proteasome Regulatory Subunit Rpn8 3
External Ids for PSMD7 Gene
Previous GeneCards Identifiers for PSMD7 Gene
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSMD7 Gene
PSMD7 (Proteasome 26S Subunit, Non-ATPase 7) is a Protein Coding gene. Diseases associated with PSMD7 include hereditary renal cell carcinoma. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is EIF3FP2.
UniProtKB/Swiss-Prot for PSMD7 Gene
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.