Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PSMD6 Gene

Aliases for PSMD6 Gene

  • Proteasome 26S Subunit, Non-ATPase 6 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 6 2 3
  • Proteasome Regulatory Particle Subunit P44S10 3 4
  • Phosphonoformate Immuno-Associated Protein 4 3 4
  • Breast Cancer-Associated Protein SGA-113M 3 4
  • P42A 3 4
  • 26S Proteasome Regulatory Subunit RPN7 4
  • 26S Proteasome Regulatory Subunit S10 4
  • SGA-113M 3
  • KIAA0107 4
  • P44S10 3
  • PFAAP4 4
  • Rpn7 3
  • S10 3

External Ids for PSMD6 Gene

Previous GeneCards Identifiers for PSMD6 Gene

  • GC00U990286

Summaries for PSMD6 Gene

Entrez Gene Summary for PSMD6 Gene

  • This gene encodes a member of the protease subunit S10 family. The encoded protein is a subunit of the 26S proteasome which colocalizes with DNA damage foci and is involved in the ATP-dependent degradation of ubiquinated proteins. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]

GeneCards Summary for PSMD6 Gene

PSMD6 (Proteasome 26S Subunit, Non-ATPase 6) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include ATPase activity. An important paralog of this gene is GPS1.

UniProtKB/Swiss-Prot for PSMD6 Gene

  • Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

Gene Wiki entry for PSMD6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD6 Gene

Genomics for PSMD6 Gene

Regulatory Elements for PSMD6 Gene

Promoters for PSMD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSMD6 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSMD6 Gene

Chromosome:
3
Start:
64,010,549 bp from pter
End:
64,024,010 bp from pter
Size:
13,462 bases
Orientation:
Minus strand

Genomic View for PSMD6 Gene

Genes around PSMD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD6 Gene

Proteins for PSMD6 Gene

  • Protein details for PSMD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15008-PSMD6_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 6
    Protein Accession:
    Q15008
    Secondary Accessions:
    • A8K2E0
    • E9PHI9
    • Q6UV22

    Protein attributes for PSMD6 Gene

    Size:
    389 amino acids
    Molecular mass:
    45531 Da
    Quaternary structure:
    • Component of the PA700 complex.

    Alternative splice isoforms for PSMD6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD6 Gene

Proteomics data for PSMD6 Gene at MOPED

Post-translational modifications for PSMD6 Gene

  • Ubiquitination at Lys 362 and Lys 372
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for PSMD6

No data available for DME Specific Peptides for PSMD6 Gene

Domains & Families for PSMD6 Gene

Gene Families for PSMD6 Gene

Suggested Antigen Peptide Sequences for PSMD6 Gene

Graphical View of Domain Structure for InterPro Entry

Q15008

UniProtKB/Swiss-Prot:

PSMD6_HUMAN :
  • Contains 1 PCI domain.
  • Belongs to the proteasome subunit S10 family.
Domain:
  • Contains 1 PCI domain.
Family:
  • Belongs to the proteasome subunit S10 family.
genes like me logo Genes that share domains with PSMD6: view

Function for PSMD6 Gene

Molecular function for PSMD6 Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
genes like me logo Genes that share phenotypes with PSMD6: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD6 Gene

Localization for PSMD6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMD6 Gene COMPARTMENTS Subcellular localization image for PSMD6 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
golgi apparatus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PSMD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PSMD6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD6 Gene

Pathways & Interactions for PSMD6 Gene

SuperPathways for PSMD6 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin-3, 5 and GM-CSF signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.48
5 Immune System
genes like me logo Genes that share pathways with PSMD6: view

Gene Ontology (GO) - Biological Process for PSMD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSMD6: view

No data available for SIGNOR curated interactions for PSMD6 Gene

Drugs & Compounds for PSMD6 Gene

(2) Drugs for PSMD6 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 769
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMD6: view

Transcripts for PSMD6 Gene

Unigene Clusters for PSMD6 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD6 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
SP1: - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - -
SP6: - -
SP7: -
SP8: -
SP9:
SP10: - - - -
SP11:

Relevant External Links for PSMD6 Gene

GeneLoc Exon Structure for
PSMD6
ECgene alternative splicing isoforms for
PSMD6

Expression for PSMD6 Gene

mRNA expression in normal human tissues for PSMD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSMD6 Gene

This gene is overexpressed in Pancreas (x4.4).

Protein differential expression in normal tissues from HIPED for PSMD6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMD6 Gene



SOURCE GeneReport for Unigene cluster for PSMD6 Gene Hs.152536

genes like me logo Genes that share expression patterns with PSMD6: view

Protein tissue co-expression partners for PSMD6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PSMD6 Gene

Orthologs for PSMD6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMD6 35
  • 91.6 (n)
  • 98.46 (a)
PSMD6 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMD6 35
  • 91.09 (n)
  • 97.69 (a)
PSMD6 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmd6 35
  • 89.12 (n)
  • 97.94 (a)
Psmd6 16
Psmd6 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSMD6 35
  • 99.74 (n)
  • 100 (a)
PSMD6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmd6 35
  • 89.46 (n)
  • 97.94 (a)
oppossum
(Monodelphis domestica)
Mammalia PSMD6 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMD6 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMD6 35
  • 82.78 (n)
  • 94.6 (a)
PSMD6 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMD6 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76241 35
psmd6 35
  • 78.06 (n)
  • 92.8 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
psmd6 35
  • 75.22 (n)
  • 93.01 (a)
psmd6 36
  • 93 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002061 35
  • 61.95 (n)
  • 69.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rpn7 35
  • 63.15 (n)
  • 70.18 (a)
Rpn7 36
  • 70 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpn-7 35
  • 55.15 (n)
  • 48.95 (a)
rpn-7 36
  • 45 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN7 38
RPN7 36
  • 33 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24820 35
  • 57.38 (n)
  • 54.38 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3520 35
barley
(Hordeum vulgare)
Liliopsida Hv.6157 35
rice
(Oryza sativa)
Liliopsida Os04g0485000 35
  • 55.56 (n)
  • 53.81 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.5635 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6338 36
  • 69 (a)
OneToOne
Species with no ortholog for PSMD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMD6 Gene

ENSEMBL:
Gene Tree for PSMD6 (if available)
TreeFam:
Gene Tree for PSMD6 (if available)

Paralogs for PSMD6 Gene

Paralogs for PSMD6 Gene

genes like me logo Genes that share paralogs with PSMD6: view

Variants for PSMD6 Gene

Sequence variations from dbSNP and Humsavar for PSMD6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs831691 -- 64,021,538(-) agcca(C/G)tgcac intron-variant
rs831692 -- 64,018,307(-) CTTAC(C/T)CTCTG intron-variant
rs2888013 -- 64,019,550(+) GTAGA(A/G)GTACA intron-variant
rs3816156 -- 64,014,036(-) GTTGC(A/T)TTTTG intron-variant
rs3816157 -- 64,013,646(-) TGAAA(C/T)GGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMD6 Gene

Variant ID Type Subtype PubMed ID
esv2725349 CNV Deletion 23290073
esv2725350 CNV Deletion 23290073
esv2725352 CNV Deletion 23290073
esv2725353 CNV Deletion 23290073
esv2725354 CNV Deletion 23290073

Variation tolerance for PSMD6 Gene

Residual Variation Intolerance Score: 47.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMD6 Gene

HapMap Linkage Disequilibrium report
PSMD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD6 Gene

Disorders for PSMD6 Gene

Relevant External Links for PSMD6

Genetic Association Database (GAD)
PSMD6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMD6

No disorders were found for PSMD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMD6 Gene

Publications for PSMD6 Gene

  1. The p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma. (PMID: 10723133) Ren S. … Ruppert J.M. (Oncogene 2000) 2 3 4 67
  2. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for PSMD6 Gene

Sources for PSMD6 Gene

Back to Top

Content