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Aliases for PSMD5 Gene

Aliases for PSMD5 Gene

  • Proteasome 26S Subunit, Non-ATPase 5 2 3
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 5 2 3
  • 26S Protease Subunit S5 Basic 3 4
  • 26S Proteasome Subunit S5B 3 4
  • KIAA0072 4
  • S5B 3

External Ids for PSMD5 Gene

Previous GeneCards Identifiers for PSMD5 Gene

  • GC09M114682
  • GC09M115224
  • GC09M117031
  • GC09M118954
  • GC09M120657
  • GC09M122617
  • GC09M123577
  • GC09M093196

Summaries for PSMD5 Gene

Entrez Gene Summary for PSMD5 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a non-ATPase subunit of the 19S regulator base that functions as a chaperone protein during 26S proteasome assembly. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMD5 Gene

PSMD5 (Proteasome 26S Subunit, Non-ATPase 5) is a Protein Coding gene. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include binding and protein binding involved in protein folding.

UniProtKB/Swiss-Prot for PSMD5 Gene

  • Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5.

Gene Wiki entry for PSMD5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD5 Gene

Genomics for PSMD5 Gene

Regulatory Elements for PSMD5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PSMD5 Gene

Chromosome:
9
Start:
120,814,779 bp from pter
End:
120,843,021 bp from pter
Size:
28,243 bases
Orientation:
Minus strand

Genomic View for PSMD5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSMD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD5 Gene

Proteins for PSMD5 Gene

  • Protein details for PSMD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16401-PSMD5_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 5
    Protein Accession:
    Q16401
    Secondary Accessions:
    • B4DZM8
    • Q15045
    • Q4VXG8

    Protein attributes for PSMD5 Gene

    Size:
    504 amino acids
    Molecular mass:
    56196 Da
    Quaternary structure:
    • Interacts with PSMC1, PSMC2, PSMD1 and PSMD6. Part of transient complex containing PSMD5, PSMC2, PSMC1 and PSMD2 formed during the assembly of the 26S proteasome.

    Alternative splice isoforms for PSMD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD5 Gene

Proteomics data for PSMD5 Gene at MOPED

Post-translational modifications for PSMD5 Gene

  • Ubiquitination at Lys 143, Lys 147, and Lys 467
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMD5 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for PSMD5

No data available for DME Specific Peptides for PSMD5 Gene

Domains & Families for PSMD5 Gene

Gene Families for PSMD5 Gene

Protein Domains for PSMD5 Gene

Suggested Antigen Peptide Sequences for PSMD5 Gene

Graphical View of Domain Structure for InterPro Entry

Q16401

UniProtKB/Swiss-Prot:

PSMD5_HUMAN :
  • Rich in dileucine repeats, which have been implicated in trafficking of a variety of transmembrane proteins
  • Belongs to the proteasome subunit S5B/HSM3 family.
Domain:
  • Rich in dileucine repeats, which have been implicated in trafficking of a variety of transmembrane proteins
Family:
  • Belongs to the proteasome subunit S5B/HSM3 family.
genes like me logo Genes that share domains with PSMD5: view

Function for PSMD5 Gene

Molecular function for PSMD5 Gene

UniProtKB/Swiss-Prot Function:
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5.

Gene Ontology (GO) - Molecular Function for PSMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with PSMD5: view

Phenotypes for PSMD5 Gene

genes like me logo Genes that share phenotypes with PSMD5: view

Animal Model Products

miRNA for PSMD5 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMD5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD5 Gene

Localization for PSMD5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMD5 Gene COMPARTMENTS Subcellular localization image for PSMD5 gene
Compartment Confidence
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for PSMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS 8811196
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0008540 colocalizes_with proteasome regulatory particle, base subcomplex IDA 19412159
GO:0022624 proteasome accessory complex ISS --
genes like me logo Genes that share ontologies with PSMD5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD5 Gene

Pathways & Interactions for PSMD5 Gene

SuperPathways for PSMD5 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin receptor SHC signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.53
5 Immune System
genes like me logo Genes that share pathways with PSMD5: view

Gene Ontology (GO) - Biological Process for PSMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with PSMD5: view

No data available for SIGNOR curated interactions for PSMD5 Gene

Drugs & Compounds for PSMD5 Gene

(2) Drugs for PSMD5 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 758
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMD5: view

Transcripts for PSMD5 Gene

Unigene Clusters for PSMD5 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMD5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - -
SP2:
SP3: -
SP4: - -
SP5:
SP6:

Relevant External Links for PSMD5 Gene

GeneLoc Exon Structure for
PSMD5
ECgene alternative splicing isoforms for
PSMD5

Expression for PSMD5 Gene

mRNA expression in normal human tissues for PSMD5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMD5 Gene



SOURCE GeneReport for Unigene cluster for PSMD5 Gene Hs.193725

genes like me logo Genes that share expression patterns with PSMD5: view

Protein tissue co-expression partners for PSMD5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMD5 Gene

Orthologs for PSMD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for PSMD5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMD5 35
  • 90.92 (n)
  • 94.04 (a)
PSMD5 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMD5 35
  • 90.11 (n)
  • 91.82 (a)
-- 36
  • 92 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Psmd5 35
  • 87.63 (n)
  • 89.88 (a)
Psmd5 16
Psmd5 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSMD5 35
  • 99.54 (n)
  • 99.8 (a)
PSMD5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmd5 35
  • 87.7 (n)
  • 89.29 (a)
oppossum
(Monodelphis domestica)
Mammalia PSMD5 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMD5 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMD5 35
  • 73.88 (n)
  • 74.8 (a)
PSMD5 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMD5 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmd5 35
  • 66.33 (n)
  • 68.51 (a)
Str.5115 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.18176 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15234 35
psmd5 35
  • 58.99 (n)
  • 57.94 (a)
psmd5 36
  • 58 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13887 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001490 35
  • 40.64 (n)
  • 26.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12096 35
  • 40.6 (n)
  • 27.57 (a)
CG12096 36
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11066 36
  • 32 (a)
OneToOne
Species with no ortholog for PSMD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PSMD5 Gene

ENSEMBL:
Gene Tree for PSMD5 (if available)
TreeFam:
Gene Tree for PSMD5 (if available)

Paralogs for PSMD5 Gene

No data available for Paralogs for PSMD5 Gene

Variants for PSMD5 Gene

Sequence variations from dbSNP and Humsavar for PSMD5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs6602 -- 120,816,686(-) ACCAA(A/G)TCACC utr-variant-3-prime, intron-variant
rs10384 -- 120,816,455(-) CCTGG(C/T)CTGAG utr-variant-3-prime, intron-variant
rs388040 -- 120,818,725(+) ACATA(C/G)ACAAA intron-variant
rs429254 -- 120,815,642(+) AAATC(A/C)TAGGC downstream-variant-500B, utr-variant-3-prime
rs430651 -- 120,818,946(+) TCTAA(G/T)AACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMD5 Gene

Variant ID Type Subtype PubMed ID
nsv893809 CNV Gain 21882294

Variation tolerance for PSMD5 Gene

Residual Variation Intolerance Score: 52.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.98; 68.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMD5 Gene

HapMap Linkage Disequilibrium report
PSMD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD5 Gene

Disorders for PSMD5 Gene

Relevant External Links for PSMD5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMD5
genes like me logo Genes that share disorders with PSMD5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMD5 Gene

Publications for PSMD5 Gene

  1. Molecular cloning and expression of a 26 S protease subunit enriched in dileucine repeats. (PMID: 7559544) Deveraux Q. … Rechsteiner M. (J. Biol. Chem. 1995) 2 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  5. RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response. (PMID: 23751493) Poulsen S.L. … Mailand N. (J. Cell Biol. 2013) 67

Products for PSMD5 Gene

Sources for PSMD5 Gene

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