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Aliases for PSMD4 Gene

Aliases for PSMD4 Gene

  • Proteasome 26S Subunit, Non-ATPase 4 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 4 2 3
  • 26S Proteasome Regulatory Subunit S5A 3 4
  • Multiubiquitin Chain-Binding Protein 3 4
  • Antisecretory Factor 1 3 4
  • MCB1 3 4
  • ASF 3 4
  • AF 3 4
  • 26S Proteasome Non-ATPase Regulatory Subunit 4 3
  • 26S Proteasome Regulatory Subunit RPN10 4
  • S5a/Antisecretory Factor Protein 3
  • Angiocidin 3
  • PUB-R5 3
  • Rpn10 3
  • AF-1 3
  • S5A 3

External Ids for PSMD4 Gene

Previous GeneCards Identifiers for PSMD4 Gene

  • GC01P149069
  • GC01P146974
  • GC01P148002
  • GC01P148443
  • GC01P148040
  • GC01P149493
  • GC01P122605

Summaries for PSMD4 Gene

Entrez Gene Summary for PSMD4 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq, Jul 2008]

CIViC summary for PSMD4 Gene

GeneCards Summary for PSMD4 Gene

PSMD4 (Proteasome 26S Subunit, Non-ATPase 4) is a Protein Coding gene. Diseases associated with PSMD4 include Angelman Syndrome. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and RET signaling. GO annotations related to this gene include poly(A) RNA binding and identical protein binding.

UniProtKB/Swiss-Prot for PSMD4 Gene

  • Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains.

Gene Wiki entry for PSMD4 Gene

Additional gene information for PSMD4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD4 Gene

Genomics for PSMD4 Gene

Regulatory Elements for PSMD4 Gene

Enhancers for PSMD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H151193 2 FANTOM5 Ensembl ENCODE dbSUPER 15.3 -57.1 -57054 7 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 ZNF143 ZNF687 PIP5K1A SETDB1 ARNT PI4KB PRPF3 GOLPH3L UBE2D3P3 PRUNE1 SCNM1
GH01H151308 2 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +57.2 57237 6 PKNOX1 FOXA2 ARNT ARID4B SIN3A YY1 ZNF766 FOS DEK SP3 PIP5K1A PRPF3 GABPB2 PI4KB MRPL9 ZNF687 RFX5 LOC100507670 SETDB1 POGZ
GH01H151054 1.7 Ensembl ENCODE dbSUPER 5.6 -195.7 -195697 9 YBX1 FEZF1 DMAP1 ZNF143 SP3 MEF2D GLIS1 NBN NR2C1 KDM1A SETDB1 PRPF3 ARNT PIP5K1A GABPB2 PI4KB UBE2D3P3 ZNF687 GOLPH3L CTSK
GH01H151010 1.5 Ensembl ENCODE dbSUPER 5.5 -242.0 -242006 4 PKNOX1 FOXA2 ATF1 MLX ARID4B FEZF1 DMAP1 YY1 FOS ATF7 SEMA6C PSMD4 HORMAD1 PRUNE1 RNU6-884P GC01M151024
GH01H151280 1.4 ENCODE dbSUPER 5.4 +27.9 27888 3 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D ZNF610 PIP5K1A SETDB1 ARNT GOLPH3L ZNF687 PRPF3 MRPL9 GABPB2 PI4KB UBE2D3P3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSMD4 on UCSC Golden Path with GeneCards custom track

Promoters for PSMD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000013599 300 1601 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for PSMD4 Gene

Chromosome:
1
Start:
151,254,700 bp from pter
End:
151,267,479 bp from pter
Size:
12,780 bases
Orientation:
Plus strand

Genomic View for PSMD4 Gene

Genes around PSMD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD4 Gene

Proteins for PSMD4 Gene

  • Protein details for PSMD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55036-PSMD4_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 4
    Protein Accession:
    P55036
    Secondary Accessions:
    • D3DV16
    • Q5VWC5
    • Q9NS92

    Protein attributes for PSMD4 Gene

    Size:
    377 amino acids
    Molecular mass:
    40737 Da
    Quaternary structure:
    • Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD4 (PubMed:27428775, PubMed:27342858). Interacts with NUB1 (PubMed:11585840). Interacts with SQSTM1 (PubMed:15340068). Interacts with UBQLN4 (PubMed:15280365). Interacts with UBE3A (PubMed:22645313). Interacts with UBQLN1 (via ubiquitin-like domain) (PubMed:15147878).

    Three dimensional structures from OCA and Proteopedia for PSMD4 Gene

    Alternative splice isoforms for PSMD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD4 Gene

Post-translational modifications for PSMD4 Gene

  • Ubiquitination at Lys40, isoforms=283, isoforms=2126, isoforms=262, and Lys365
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for PSMD4 (S5a/Angiocidin)
  • Cell Signaling Technology (CST) Antibodies for PSMD4 (PSMD4)
  • Cloud-Clone Corp. Antibodies for PSMD4

No data available for DME Specific Peptides for PSMD4 Gene

Domains & Families for PSMD4 Gene

Gene Families for PSMD4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for PSMD4 Gene

Graphical View of Domain Structure for InterPro Entry

P55036

UniProtKB/Swiss-Prot:

PSMD4_HUMAN :
  • The 2 UIM motifs are involved in the binding to a multi-ubiquitin chain in a cooperative way.
  • Belongs to the proteasome subunit S5A family.
Domain:
  • The 2 UIM motifs are involved in the binding to a multi-ubiquitin chain in a cooperative way.
Family:
  • Belongs to the proteasome subunit S5A family.
genes like me logo Genes that share domains with PSMD4: view

Function for PSMD4 Gene

Molecular function for PSMD4 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (prosome,macropain 26S) regulator of proteasome,non ATPase subunit,50kDa,more acidic subunit 5A,specifically binding ubiquitin-lysozyme conjugates antisecretory factor 1,inhibiting intestinal fluid secretion
UniProtKB/Swiss-Prot Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains.

Gene Ontology (GO) - Molecular Function for PSMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 8570649
GO:0008134 transcription factor binding IEA --
GO:0031593 polyubiquitin binding IBA --
GO:0042802 identical protein binding IPI 16990800
genes like me logo Genes that share ontologies with PSMD4: view
genes like me logo Genes that share phenotypes with PSMD4: view

Animal Models for PSMD4 Gene

MGI Knock Outs for PSMD4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PSMD4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMD4 Gene

Localization for PSMD4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMD4 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA,IEA 17323924
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with PSMD4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD4 Gene

Pathways & Interactions for PSMD4 Gene

SuperPathways for PSMD4 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMD4: view

Gene Ontology (GO) - Biological Process for PSMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with PSMD4: view

No data available for SIGNOR curated interactions for PSMD4 Gene

Drugs & Compounds for PSMD4 Gene

(17) Drugs for PSMD4 Gene - From: ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 814
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
AM 114 Pharma 20S proteasome inhibitor 0
Bortezomib (PS-341) Pharma Proteasome Inhibitor 0
Carfilzomib (PR-171) Pharma Proteasome inhibitor,epoxomicin analog 0

(1) Additional Compounds for PSMD4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(14) ApexBio Compounds for PSMD4 Gene

Compound Action Cas Number
AM 114 20S proteasome inhibitor 856849-35-9
Bortezomib (PS-341) Proteasome Inhibitor 179324-69-7
Carfilzomib (PR-171) Proteasome inhibitor,epoxomicin analog 868540-17-4
Celastrol Antioxidant, anti-inflammatory and immunosuppressive agent 34157-83-0
CEP-18770 Proteasome inhibitor 847499-27-8
Dihydroeponemycin Proteasome inhibitor,antitumor reagent,eponemycin ddrivative 126463-64-7
Epoxomicin Proteasome inhibitor 134381-21-8
MG-132 Proteasome inhibitor, Cell permeable, reversible 133407-82-6
MLN2238 β5 site of the 20S proteasome inhibitor 1072833-77-2
MLN9708 Proteasome inhibitor 1201902-80-8
ONX-0914 (PR-957) Immunoproteasome inhibitor,potent and selective 960374-59-8
Oprozomib (ONX-0912) Proteasome inhibitor 935888-69-0
PI-1840 Chymotrypsin-like (CT-L) inhibitor 1401223-22-0
PSI Proteasome inhibitor 158442-41-2
genes like me logo Genes that share compounds with PSMD4: view

Drug Products

Transcripts for PSMD4 Gene

Unigene Clusters for PSMD4 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PSMD4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - - -
SP2: - -
SP3:
SP4: -
SP5: -
SP6: -
SP7:

Relevant External Links for PSMD4 Gene

GeneLoc Exon Structure for
PSMD4
ECgene alternative splicing isoforms for
PSMD4

Expression for PSMD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMD4 Gene

This gene is overexpressed in Amniocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMD4 Gene



Protein tissue co-expression partners for PSMD4 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSMD4 Gene:

PSMD4

SOURCE GeneReport for Unigene cluster for PSMD4 Gene:

Hs.505059

Evidence on tissue expression from TISSUES for PSMD4 Gene

  • Lung(4.8)
  • Nervous system(4.7)
  • Liver(4.4)
  • Intestine(3)
  • Muscle(2.6)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with PSMD4: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMD4 Gene

Orthologs for PSMD4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMD4 33 34
  • 99.65 (n)
cow
(Bos Taurus)
Mammalia PSMD4 33 34
  • 92.93 (n)
dog
(Canis familiaris)
Mammalia PSMD4 33 34
  • 92.75 (n)
rat
(Rattus norvegicus)
Mammalia Psmd4 33
  • 91.21 (n)
mouse
(Mus musculus)
Mammalia Psmd4 33 16 34
  • 90.45 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMD4 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMD4 34 34
  • 95 (a)
OneToMany
LOC100857577 33
  • 80.77 (n)
lizard
(Anolis carolinensis)
Reptilia PSMD4 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6951 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3773 33
zebrafish
(Danio rerio)
Actinopterygii psmd4b 34
  • 82 (a)
OneToMany
psmd4a 33 34
  • 77.93 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pros54 35 33 34
  • 63.64 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005559 33
  • 63.31 (n)
worm
(Caenorhabditis elegans)
Secernentea rpn-10 33 34
  • 55.56 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL078C 33
  • 56.7 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN10 33 34 36
  • 54.32 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B03916g 33
  • 53.21 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RPN10 33
  • 55.62 (n)
rice
(Oryza sativa)
Liliopsida Os03g0243300 33
  • 53.6 (n)
Os.4677 33
barley
(Hordeum vulgare)
Liliopsida Hv.2319 33
corn
(Zea mays)
Liliopsida Zm.5851 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8096 34
  • 55 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpn10 33
  • 53.09 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02982 33
  • 51.8 (n)
Species where no ortholog for PSMD4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMD4 Gene

ENSEMBL:
Gene Tree for PSMD4 (if available)
TreeFam:
Gene Tree for PSMD4 (if available)

Paralogs for PSMD4 Gene

(1) SIMAP similar genes for PSMD4 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for PSMD4 Gene

genes like me logo Genes that share paralogs with PSMD4: view

No data available for Paralogs for PSMD4 Gene

Variants for PSMD4 Gene