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Aliases for PSMD4 Gene

Aliases for PSMD4 Gene

  • Proteasome 26S Subunit, Non-ATPase 4 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 4 2 3
  • 26S Proteasome Regulatory Subunit S5A 3 4
  • Multiubiquitin Chain-Binding Protein 3 4
  • Antisecretory Factor 1 3 4
  • MCB1 3 4
  • ASF 3 4
  • AF 3 4
  • 26S Proteasome Non-ATPase Regulatory Subunit 4 3
  • 26S Proteasome Regulatory Subunit RPN10 4
  • S5a/Antisecretory Factor Protein 3
  • Angiocidin 3
  • PUB-R5 3
  • Rpn10 3
  • AF-1 3
  • S5A 3

External Ids for PSMD4 Gene

Previous GeneCards Identifiers for PSMD4 Gene

  • GC01P149069
  • GC01P146974
  • GC01P148002
  • GC01P148443
  • GC01P148040
  • GC01P149493
  • GC01P122605

Summaries for PSMD4 Gene

Entrez Gene Summary for PSMD4 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMD4 Gene

PSMD4 (Proteasome 26S Subunit, Non-ATPase 4) is a Protein Coding gene. Diseases associated with PSMD4 include Angelman Syndrome. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include poly(A) RNA binding and identical protein binding.

UniProtKB/Swiss-Prot for PSMD4 Gene

  • Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion.

Gene Wiki entry for PSMD4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD4 Gene

Genomics for PSMD4 Gene

Regulatory Elements for PSMD4 Gene

Enhancers for PSMD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PSMD4 on UCSC Golden Path with GeneCards custom track

Promoters for PSMD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSMD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSMD4 Gene

Chromosome:
1
Start:
151,254,700 bp from pter
End:
151,267,479 bp from pter
Size:
12,780 bases
Orientation:
Plus strand

Genomic View for PSMD4 Gene

Genes around PSMD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD4 Gene

Proteins for PSMD4 Gene

  • Protein details for PSMD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55036-PSMD4_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 4
    Protein Accession:
    P55036
    Secondary Accessions:
    • D3DV16
    • Q5VWC5
    • Q9NS92

    Protein attributes for PSMD4 Gene

    Size:
    377 amino acids
    Molecular mass:
    40737 Da
    Quaternary structure:
    • The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively (By similarity). Directly interacts with NUB1. Interacts with SQSTM1. Interacts with UBQLN4. Interacts with UBE3A. Interacts with UBQLN1 (via ubiquitin-like domain).

    Three dimensional structures from OCA and Proteopedia for PSMD4 Gene

    Alternative splice isoforms for PSMD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD4 Gene

Post-translational modifications for PSMD4 Gene

  • Ubiquitination at Lys 40, Lys 83, Lys 126, Lys 262, and Lys 365
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMD4 Gene

Antibody Products

  • R&D Systems Antibodies for PSMD4 (S5a/Angiocidin)
  • Cell Signaling Technology (CST) Antibodies for PSMD4 (PSMD4)
  • Cloud-Clone Corp. Antibodies for PSMD4

No data available for DME Specific Peptides for PSMD4 Gene

Domains & Families for PSMD4 Gene

Gene Families for PSMD4 Gene

Protein Domains for PSMD4 Gene

Graphical View of Domain Structure for InterPro Entry

P55036

UniProtKB/Swiss-Prot:

PSMD4_HUMAN :
  • The 2 UIM motifs are involved in the binding to a multi-ubiquitin chain in a cooperative way.
  • Belongs to the proteasome subunit S5A family.
Domain:
  • The 2 UIM motifs are involved in the binding to a multi-ubiquitin chain in a cooperative way.
  • Contains 2 UIM (ubiquitin-interacting motif) domains.
  • Contains 1 VWFA domain.
Family:
  • Belongs to the proteasome subunit S5A family.
genes like me logo Genes that share domains with PSMD4: view

Function for PSMD4 Gene

Molecular function for PSMD4 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (prosome,macropain 26S) regulator of proteasome,non ATPase subunit,50kDa,more acidic subunit 5A,specifically binding ubiquitin-lysozyme conjugates antisecretory factor 1,inhibiting intestinal fluid secretion
UniProtKB/Swiss-Prot Function:
Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion.

Gene Ontology (GO) - Molecular Function for PSMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10488153
GO:0008134 transcription factor binding IEA --
GO:0031593 polyubiquitin binding IBA --
GO:0042802 identical protein binding IPI 16990800
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with PSMD4: view
genes like me logo Genes that share phenotypes with PSMD4: view

Animal Models for PSMD4 Gene

MGI Knock Outs for PSMD4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMD4 Gene

Localization for PSMD4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMD4 Gene COMPARTMENTS Subcellular localization image for PSMD4 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PSMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 17323924
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMD4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD4 Gene

Pathways & Interactions for PSMD4 Gene

SuperPathways for PSMD4 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin-3, 5 and GM-CSF signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.48
5 Immune System
genes like me logo Genes that share pathways with PSMD4: view

Gene Ontology (GO) - Biological Process for PSMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006521 regulation of cellular amino acid metabolic process TAS --
genes like me logo Genes that share ontologies with PSMD4: view

No data available for SIGNOR curated interactions for PSMD4 Gene

Drugs & Compounds for PSMD4 Gene

(17) Drugs for PSMD4 Gene - From: ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 783
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
AM 114 Pharma 20S proteasome inhibitor 0
Bortezomib (PS-341) Pharma Proteasome Inhibitor 0
Carfilzomib (PR-171) Pharma Proteasome inhibitor,epoxomicin analog 0

(1) Additional Compounds for PSMD4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(14) ApexBio Compounds for PSMD4 Gene

Compound Action Cas Number
AM 114 20S proteasome inhibitor 856849-35-9
Bortezomib (PS-341) Proteasome Inhibitor 179324-69-7
Carfilzomib (PR-171) Proteasome inhibitor,epoxomicin analog 868540-17-4
Celastrol Antioxidant, anti-inflammatory and immunosuppressive agent 34157-83-0
CEP-18770 Proteasome inhibitor 847499-27-8
Dihydroeponemycin Proteasome inhibitor,antitumor reagent,eponemycin ddrivative 126463-64-7
Epoxomicin Proteasome inhibitor 134381-21-8
MG-132 Proteasome inhibitor, Cell permeable, reversible 133407-82-6
MLN2238 β5 site of the 20S proteasome inhibitor 1072833-77-2
MLN9708 Proteasome inhibitor 1201902-80-8
ONX-0914 (PR-957) Immunoproteasome inhibitor,potent and selective 960374-59-8
Oprozomib (ONX-0912) Proteasome inhibitor 935888-69-0
PI-1840 Chymotrypsin-like (CT-L) inhibitor 1401223-22-0
PSI Proteasome inhibitor 158442-41-2
genes like me logo Genes that share compounds with PSMD4: view

Transcripts for PSMD4 Gene

Unigene Clusters for PSMD4 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - - -
SP2: - -
SP3:
SP4: -
SP5: -
SP6: -
SP7:

Relevant External Links for PSMD4 Gene

GeneLoc Exon Structure for
PSMD4
ECgene alternative splicing isoforms for
PSMD4

Expression for PSMD4 Gene

mRNA expression in normal human tissues for PSMD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMD4 Gene

This gene is overexpressed in Amniocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMD4 Gene



Protein tissue co-expression partners for PSMD4 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSMD4 Gene:

PSMD4

SOURCE GeneReport for Unigene cluster for PSMD4 Gene:

Hs.505059
genes like me logo Genes that share expression patterns with PSMD4: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMD4 Gene

Orthologs for PSMD4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMD4 34
  • 92.93 (n)
  • 99.2 (a)
PSMD4 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMD4 34
  • 92.75 (n)
  • 98.94 (a)
PSMD4 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmd4 34
  • 90.45 (n)
  • 96.69 (a)
Psmd4 16
Psmd4 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSMD4 34
  • 99.65 (n)
  • 100 (a)
PSMD4 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmd4 34
  • 91.21 (n)
  • 98.9 (a)
oppossum
(Monodelphis domestica)
Mammalia PSMD4 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857577 34
  • 80.77 (n)
  • 95.33 (a)
PSMD4 35
  • 95 (a)
OneToMany
PSMD4 35
  • 95 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia PSMD4 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6951 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.3773 34
zebrafish
(Danio rerio)
Actinopterygii psmd4a 34
  • 77.93 (n)
  • 88.27 (a)
psmd4a 35
  • 87 (a)
OneToMany
psmd4b 35
  • 82 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pros54 36
  • 56 (a)
Pros54 34
  • 63.64 (n)
  • 65.06 (a)
Pros54 35
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005559 34
  • 63.31 (n)
  • 63.69 (a)
worm
(Caenorhabditis elegans)
Secernentea rpn-10 34
  • 55.56 (n)
  • 52.6 (a)
rpn-10 35
  • 51 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL078C 34
  • 56.7 (n)
  • 52.68 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B03916g 34
  • 53.21 (n)
  • 51.12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN10 34
  • 54.32 (n)
  • 53.12 (a)
RPN10 35
  • 48 (a)
OneToOne
RPN10 37
thale cress
(Arabidopsis thaliana)
eudicotyledons RPN10 34
  • 55.62 (n)
  • 49.25 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2319 34
rice
(Oryza sativa)
Liliopsida Os.4677 34
Os03g0243300 34
  • 53.6 (n)
  • 46.31 (a)
corn
(Zea mays)
Liliopsida Zm.5851 34
bread mold
(Neurospora crassa)
Ascomycetes NCU02982 34
  • 51.8 (n)
  • 53.15 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpn10 34
  • 53.09 (n)
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8096 35
  • 55 (a)
OneToOne
Species where no ortholog for PSMD4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMD4 Gene

ENSEMBL:
Gene Tree for PSMD4 (if available)
TreeFam:
Gene Tree for PSMD4 (if available)

Paralogs for PSMD4 Gene

(1) SIMAP similar genes for PSMD4 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for PSMD4 Gene

genes like me logo Genes that share paralogs with PSMD4: view

No data available for Paralogs for PSMD4 Gene

Variants for PSMD4 Gene

Sequence variations from dbSNP and Humsavar for PSMD4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4922 -- 151,267,237(+) CCTCC(C/G)AGGTG reference, missense
rs7489 -- 151,266,575(+) ACATC(C/T)GAGCC reference, synonymous-codon
rs11430 -- 151,267,244(+) GGTGT(A/G)GATCC reference, synonymous-codon
rs1056406 -- 151,266,071(+) TGCAG(C/T)TTCTG reference, missense
rs1064203 -- 151,267,327(+) GAAGG(A/G)GGAAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PSMD4 Gene

Variant ID Type Subtype PubMed ID
dgv2n68 CNV loss 17160897
esv3587521 CNV loss 21293372
esv3587522 CNV gain 21293372
nsv522840 CNV gain 19592680

Variation tolerance for PSMD4 Gene

Residual Variation Intolerance Score: 16.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD4 Gene

Disorders for PSMD4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSMD4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
angelman syndrome
  • as
- elite association - COSMIC cancer census association via MalaCards
Search PSMD4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSMD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMD4
genes like me logo Genes that share disorders with PSMD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMD4 Gene

Publications for PSMD4 Gene

  1. Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1. (PMID: 11585840) Kamitani T. … Yeh E.T.H. (J. Biol. Chem. 2001) 3 4 22 65
  2. Molecular cloning and expression of a multiubiquitin chain binding subunit of the human 26S protease. (PMID: 8641424) Ferrell K. … Rechsteiner M. (FEBS Lett. 1996) 2 3 4 65
  3. Molecular cloning and expression of a pituitary gland protein modulating intestinal fluid secretion. (PMID: 7657640) Johansson E. … Loennroth C. (J. Biol. Chem. 1995) 3 4 22 65
  4. Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes. (PMID: 22645313) Martinez-Noel G. … Howley P.M. (Mol. Cell. Biol. 2012) 3 4 65
  5. Differential interaction of the E3 ligase parkin with the proteasomal subunit S5a and the endocytic protein Eps15. (PMID: 19875440) Safadi S.S. … Shaw G.S. (J. Biol. Chem. 2010) 3 22 65

Products for PSMD4 Gene

Sources for PSMD4 Gene

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