Aliases for PSMD4 Gene
Aliases for PSMD4 Gene
External Ids for PSMD4 Gene
- HGNC: 9561
- Entrez Gene: 5710
- Ensembl: ENSG00000159352
- OMIM: 601648
- UniProtKB: P55036
Previous GeneCards Identifiers for PSMD4 Gene
- GC01P149069
- GC01P146974
- GC01P148002
- GC01P148443
- GC01P148040
- GC01P149493
- GC01P122605
Summaries for PSMD4 Gene
-
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSMD4 Gene
PSMD4 (Proteasome 26S Subunit, Non-ATPase 4) is a Protein Coding gene. Diseases associated with PSMD4 include Angelman Syndrome and Spherocytosis, Type 5. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include identical protein binding.
UniProtKB/Swiss-Prot for PSMD4 Gene
-
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD4 Gene
Genomics for PSMD4 Gene
GeneHancer (GH) Regulatory Elements for PSMD4 Gene
Promoters and enhancers for PSMD4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PSMD4 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PSMD4 Gene
Genomic Locations for PSMD4 Gene
- chr1:151,254,700-151,267,479
- (GRCh38/hg38)
- Size:
- 12,780 bases
- Orientation:
- Plus strand
- chr1:151,227,179-151,239,955
- (GRCh37/hg19)
Genomic View for PSMD4 Gene
Genes around PSMD4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.3 by Ensembl
- 1q21.3 by Entrez Gene
- 1q21.3 by HGNC
PSMD4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSMD4 Gene
Proteins for PSMD4 Gene
-
Protein details for PSMD4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P55036-PSMD4_HUMAN
- Recommended name:
- 26S proteasome non-ATPase regulatory subunit 4
- Protein Accession:
- P55036
- D3DV16
- Q5VWC5
- Q9NS92
Protein attributes for PSMD4 Gene
- Size:
- 377 amino acids
- Molecular mass:
- 40737 Da
- Quaternary structure:
-
- Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD4 (PubMed:27428775, PubMed:27342858). Interacts with NUB1 (PubMed:11585840). Interacts with SQSTM1 (PubMed:15340068). Interacts with UBQLN4 (PubMed:15280365). Interacts with UBE3A (PubMed:22645313). Interacts with UBQLN1 (via ubiquitin-like domain) (PubMed:15147878).
Three dimensional structures from OCA and Proteopedia for PSMD4 Gene
Protein Expression for PSMD4 Gene
Post-translational modifications for PSMD4 Gene
- Ubiquitination at isoforms=240, Lys83, Lys126, isoforms=262, and Lys365
Other Protein References for PSMD4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PSMD4 (S5a/Angiocidin)
- Cell Signaling Technology (CST) Antibodies for PSMD4 (PSMD4)
-
Custom Antibody ServicesOriGene Antibodies for PSMD4
- Novus Biologicals Antibodies for PSMD4
-
Abcam antibodies for PSMD4
-
Cloud-Clone Corp. Antibodies for PSMD4
- Invitrogen Antibodies for PSMD4
- GeneTex PSMD4 antibody for PSMD4
-
Santa Cruz Biotechnology (SCBT) Antibodies for PSMD4
Protein Products
- R&D Systems Proteins and Enzymes for PSMD4 (S5a/Angiocidin)
-
OriGene Purified Proteins for PSMD4
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMD4
- Origene Custom Protein Services for PSMD4
-
Cloud-Clone Corp. Proteins for PSMD4
- Search GeneTex for Proteins for PSMD4
-
ProSci Proteins for PSMD4
-
Abcam proteins for PSMD4
Assay Products
- R&D Systems Activity Assays and other biochemical assays for PSMD4 (S5a/Angiocidin)
- antibodies-online: Search results for 1 available Psmd4 Elisa Kits ranked by validation data
- Compare Top Psmd4 Elisa Kits
-
Recommended
No data available for DME Specific Peptides for PSMD4 Gene
Domains & Families for PSMD4 Gene
Gene Families for PSMD4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for PSMD4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PSMD4 Gene
Graphical View of Domain Structure for InterPro Entry
P55036UniProtKB/Swiss-Prot:
PSMD4_HUMAN :- The 2 UIM motifs are involved in the binding to a multi-ubiquitin chain in a cooperative way.
- Belongs to the proteasome subunit S5A family.
- Domain:
-
- The 2 UIM motifs are involved in the binding to a multi-ubiquitin chain in a cooperative way.
- Family:
-
- Belongs to the proteasome subunit S5A family.
Function for PSMD4 Gene
Molecular function for PSMD4 Gene
- GENATLAS Biochemistry:
- multicatalytic proteinase complex (prosome,macropain 26S) regulator of proteasome,non ATPase subunit,50kDa,more acidic subunit 5A,specifically binding ubiquitin-lysozyme conjugates antisecretory factor 1,inhibiting intestinal fluid secretion
- UniProtKB/Swiss-Prot Function:
- Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains.
Phenotypes From GWAS Catalog for PSMD4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IDA,HDA | 22658674 |
| GO:0005515 | protein binding | IPI | 10488153 |
| GO:0008134 | transcription factor binding | IEA | -- |
| GO:0031593 | polyubiquitin modification-dependent protein binding | IBA | -- |
| GO:0042802 | identical protein binding | IPI | 16990800 |
Phenotypes for PSMD4 Gene
- MGI mutant phenotypes for PSMD4:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for PSMD4:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- shRNA abundance <= 50%
- Increased shRNA abundance (Z-score > 2)
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Decreased NF-kappaB reporter expression
- Increased G1 DNA content
- G0/1 arrest
- Decreased HIV-LTR-beta-galactosidase protein expression
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased cell death HMECs cells
- Decreased homologous recombination repair frequency
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression
- Decreased shRNA abundance (Z-score < -2)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for PSMD4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMD4 gene
- Search ViGene Biosciences for PSMD4
CRISPR Products
-
OriGene CRISPR knockouts for PSMD4
- genomics-online: gRNA clones - Search results for available Psmd4 gene related products
- Applied Biological Materials CRISPR for PSMD4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMD4
miRNA for PSMD4 Gene
- miRTarBase miRNAs that target PSMD4
miRNA Products
- Search ViGene Biosciences for PSMD4
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMD4
- Browse OriGene Inhibitory RNA Products For PSMD4
- genomics-online: shRNA clones - Search results for available Psmd4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMD4 gene
Clone Products
- Sino Biological Human cDNA Clone for PSMD4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- genomics-online: cdna clones - Search results for available Psmd4 gene related products
- orf clones - Search results for available Psmd4 gene related products
- Applied Biological Materials Clones for PSMD4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PSMD4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PSMD4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMD4 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMD4 Gene
Localization for PSMD4 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 1 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000502 | proteasome complex | IEA,IDA | 17323924 |
| GO:0005634 | nucleus | IBA | -- |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS,IDA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD4 Gene
Pathways & Interactions for PSMD4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.78
.78
.70
.47
.31
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | Chks in Checkpoint Regulation | ||
| 4 | HIV Life Cycle |
.65
|
.45
|
| 5 | Class I MHC mediated antigen processing and presentation | ||
Pathways by source for PSMD4 Gene
1 Sino Biological pathway for PSMD4 Gene
2 BioSystems pathways for PSMD4 Gene
2 KEGG pathways for PSMD4 Gene
3 GeneGo (Thomson Reuters) pathways for PSMD4 Gene
19 Qiagen pathways for PSMD4 Gene
Interacting Proteins for PSMD4 Gene
Selected Interacting proteins:
P55036-PSMD4_HUMAN
ENSP00000357879
for PSMD4 Gene via
MINT
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | -- |
No data available for SIGNOR curated interactions for PSMD4 Gene
Drugs & Compounds for PSMD4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Bortezomib | Approved, Investigational | Pharma | inhibitor, other | Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors | 826 | |
| carfilzomib | Approved, Investigational | Pharma | other, Inhibitor | Other, 20S Proteasome Inhibitor | 0 | |
| AM 114 | Pharma | 20S proteasome inhibitor | 0 | |||
| Bortezomib (PS-341) | Pharma | Proteasome Inhibitor | 0 | |||
| Carfilzomib (PR-171) | Pharma | Proteasome inhibitor,epoxomicin analog | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(14) ApexBio Compounds for PSMD4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AM 114 | 20S proteasome inhibitor | 856849-35-9 |
| Bortezomib (PS-341) | Proteasome Inhibitor | 179324-69-7 |
| Carfilzomib (PR-171) | Proteasome inhibitor,epoxomicin analog | 868540-17-4 |
| Celastrol | Antioxidant, anti-inflammatory and immunosuppressive agent | 34157-83-0 |
| CEP-18770 | Proteasome inhibitor | 847499-27-8 |
| Dihydroeponemycin | Proteasome inhibitor,antitumor reagent,eponemycin ddrivative | 126463-64-7 |
| Epoxomicin | Proteasome inhibitor | 134381-21-8 |
| MG-132 | Proteasome inhibitor, Cell permeable, reversible | 133407-82-6 |
| MLN2238 | β5 site of the 20S proteasome inhibitor | 1072833-77-2 |
| MLN9708 | Proteasome inhibitor | 1201902-80-8 |
| ONX-0914 (PR-957) | Immunoproteasome inhibitor,potent and selective | 960374-59-8 |
| Oprozomib (ONX-0912) | Proteasome inhibitor | 935888-69-0 |
| PI-1840 | Chymotrypsin-like (CT-L) inhibitor | 1401223-22-0 |
| PSI | Proteasome inhibitor | 158442-41-2 |
Transcripts for PSMD4 Gene
mRNA/cDNA for PSMD4 Gene
- (6) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (548) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PSMD4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PSMD4
- genomics-online: gRNA clones - Search results for available Psmd4 gene related products
- Applied Biological Materials CRISPR for PSMD4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMD4
miRNA Products
- Search ViGene Biosciences for PSMD4
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMD4
- Browse OriGene Inhibitory RNA Products For PSMD4
- genomics-online: shRNA clones - Search results for available Psmd4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMD4 gene
Clone Products
- Sino Biological Human cDNA Clone for PSMD4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- genomics-online: cdna clones - Search results for available Psmd4 gene related products
- orf clones - Search results for available Psmd4 gene related products
- Applied Biological Materials Clones for PSMD4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||
| SP7: |
Expression for PSMD4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Amniocyte (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMD4 Gene
NURSA nuclear receptor signaling pathways regulating expression of PSMD4 Gene:
PSMD4SOURCE GeneReport for Unigene cluster for PSMD4 Gene:
Hs.505059Evidence on tissue expression from TISSUES for PSMD4 Gene
- Lung(4.8)
- Nervous system(4.7)
- Liver(4.4)
- Intestine(3)
- Muscle(2.6)
- Eye(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for PSMD4
-
OriGene qPCR primer pairs for PSMD4
- genomics-online: primer clones - Search results for available Psmd4 gene related products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMD4 Gene
Orthologs for PSMD4 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PSMD4 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | PSMD4 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PSMD4 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Psmd4 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Psmd4 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PSMD4 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PSMD4 34 34 |
|
OneToMany | |
| LOC100857577 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | PSMD4 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.6951 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.3773 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | psmd4b 34 |
|
OneToMany | |
| psmd4a 33 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Pros54 35 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005559 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | rpn-10 33 34 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ABL078C 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPN10 33 34 36 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B03916g 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | RPN10 33 |
|