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Aliases for PSMD3 Gene

Aliases for PSMD3 Gene

  • Proteasome 26S Subunit, Non-ATPase 3 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 3 2 3
  • Tissue Specific Transplantation Antigen 2 2 3
  • 26S Proteasome Regulatory Subunit RPN3 3 4
  • 26S Proteasome Regulatory Subunit S3 3 4
  • Proteasome Subunit P58 3 4
  • 26S Proteasome Non-ATPase Regulatory Subunit 3 3
  • TSTA2 3
  • RPN3 3
  • P58 3
  • S3 3

External Ids for PSMD3 Gene

Previous HGNC Symbols for PSMD3 Gene

  • TSTA2

Previous GeneCards Identifiers for PSMD3 Gene

  • GC17M037645
  • GC17P040134
  • GC17P038047
  • GC17P038512
  • GC17P035390
  • GC17P038137
  • GC17P033931

Summaries for PSMD3 Gene

Entrez Gene Summary for PSMD3 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMD3 Gene

PSMD3 (Proteasome 26S Subunit, Non-ATPase 3) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and RET signaling. GO annotations related to this gene include enzyme regulator activity.

UniProtKB/Swiss-Prot for PSMD3 Gene

  • Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

Gene Wiki entry for PSMD3 Gene

Additional gene information for PSMD3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD3 Gene

Genomics for PSMD3 Gene

Regulatory Elements for PSMD3 Gene

Enhancers for PSMD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H040061 2.2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10.6 +88.5 88528 14 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 MED24 MED1 GSDMA SMARCE1 MSL1 RAPGEFL1 PSMD3 TCAP ORMDL3 THRA
GH17H039958 1.2 Ensembl ENCODE 16.1 -21.7 -21748 0 PKNOX1 ATF1 ARNT ARID4B SLC30A9 ZNF143 ATF7 RUNX3 REST MIER2 GSDMA PSMD3 LRRC3C ORMDL3 GSDMB
GH17H040086 1 ENCODE dbSUPER 10.7 +105.8 105845 0 CTCF RB1 ARID4B THRB RAD21 CC2D1A PATZ1 SMC3 ZNF143 DEK MED24 THRA MSL1 PSMD3 GSDMA LRRC3C ORMDL3 CDC6 GC17P040082 NR1D1
GH17H039952 0.9 ENCODE 11.6 -27.6 -27604 1 TBP HDGF PKNOX1 ARID4B KLF17 RAD21 RARA YY1 ETS1 GLIS2 GSDMA GSDMB PSMD3 GC17M039945
GH17H040031 0.9 ENCODE dbSUPER 11.4 +51.7 51681 2 ZSCAN4 REST RAD21 FOXA1 YY1 JUND HNF4G HNF4A MED24 GSDMA THRA PSMD3 RAPGEFL1 ORMDL3 LRRC3C CDC6 SNORD124 GC17P040059
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSMD3 on UCSC Golden Path with GeneCards custom track

Promoters for PSMD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094013 332 2201 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 SP3

Genomic Location for PSMD3 Gene

Chromosome:
17
Start:
39,980,768 bp from pter
End:
39,997,960 bp from pter
Size:
17,193 bases
Orientation:
Plus strand

Genomic View for PSMD3 Gene

Genes around PSMD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD3 Gene

Proteins for PSMD3 Gene

  • Protein details for PSMD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43242-PSMD3_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 3
    Protein Accession:
    O43242
    Secondary Accessions:
    • B3KMW9
    • B4DT72
    • Q96EI2
    • Q9BQA4

    Protein attributes for PSMD3 Gene

    Size:
    534 amino acids
    Molecular mass:
    60978 Da
    Quaternary structure:
    • Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD3, a base containing 6 ATPases and few additional components (PubMed:27428775, PubMed:27342858). Interacts with UBQLN1 (via ubiquitin-like domain) (PubMed:15147878).

    Three dimensional structures from OCA and Proteopedia for PSMD3 Gene

    Alternative splice isoforms for PSMD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD3 Gene

Post-translational modifications for PSMD3 Gene

  • Ubiquitination at Lys54, Lys223, isoforms=2269, isoforms=2273, isoforms=2374, Lys440, Lys461, and isoforms=492
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PSMD3 Gene

Domains & Families for PSMD3 Gene

Gene Families for PSMD3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

O43242

UniProtKB/Swiss-Prot:

PSMD3_HUMAN :
  • Belongs to the proteasome subunit S3 family.
Family:
  • Belongs to the proteasome subunit S3 family.
genes like me logo Genes that share domains with PSMD3: view

Function for PSMD3 Gene

Molecular function for PSMD3 Gene

UniProtKB/Swiss-Prot Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

Phenotypes From GWAS Catalog for PSMD3 Gene

Gene Ontology (GO) - Molecular Function for PSMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15147878
GO:0030234 enzyme regulator activity IEA --
genes like me logo Genes that share ontologies with PSMD3: view
genes like me logo Genes that share phenotypes with PSMD3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PSMD3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD3 Gene

Localization for PSMD3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMD3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA,TAS 17323924
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMD3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD3 Gene

Pathways & Interactions for PSMD3 Gene

SuperPathways for PSMD3 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMD3: view

Gene Ontology (GO) - Biological Process for PSMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with PSMD3: view

No data available for SIGNOR curated interactions for PSMD3 Gene

Drugs & Compounds for PSMD3 Gene

(2) Drugs for PSMD3 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 814
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMD3: view

Transcripts for PSMD3 Gene

Unigene Clusters for PSMD3 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PSMD3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for PSMD3 Gene

GeneLoc Exon Structure for
PSMD3
ECgene alternative splicing isoforms for
PSMD3

Expression for PSMD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMD3 Gene

mRNA differential expression in normal tissues according to GTEx for PSMD3 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for PSMD3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMD3 Gene



Protein tissue co-expression partners for PSMD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMD3 Gene:

PSMD3

SOURCE GeneReport for Unigene cluster for PSMD3 Gene:

Hs.12970

Evidence on tissue expression from TISSUES for PSMD3 Gene

  • Skin(4.7)
  • Nervous system(4.7)
  • Lung(4.6)
  • Eye(4.5)
  • Liver(4.4)
  • Pancreas(4.3)
  • Intestine(3.1)
  • Kidney(3)
  • Blood(2.4)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with PSMD3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMD3 Gene

Orthologs for PSMD3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMD3 33 34
  • 99.63 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMD3 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSMD3 33 34
  • 92.57 (n)
dog
(Canis familiaris)
Mammalia PSMD3 33 34
  • 92.2 (n)
mouse
(Mus musculus)
Mammalia Psmd3 33 16 34
  • 89.31 (n)
rat
(Rattus norvegicus)
Mammalia Psmd3 33
  • 89.18 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PSMD3 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMD3 33 34
  • 81.63 (n)
lizard
(Anolis carolinensis)
Reptilia PSMD3 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmd3 33
  • 77.69 (n)
Str.15289 33
zebrafish
(Danio rerio)
Actinopterygii psmd3 33 34
  • 78.98 (n)
zgc65867 33
African malaria mosquito
(Anopheles gambiae)
Insecta PSMD3_ANOGA 33
  • 62.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rpn3 33 34
  • 60.95 (n)
worm
(Caenorhabditis elegans)
Secernentea rpn-3 33 34
  • 50.4 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR164W 33
  • 48.48 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN3 33 34 36
  • 45.58 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D10824g 33
  • 44.13 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G75990 33
  • 52.57 (n)
soybean
(Glycine max)
eudicotyledons Gma.5792 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3192 33
rice
(Oryza sativa)
Liliopsida Os08g0550100 33
  • 53.01 (n)
Os.15703 33
barley
(Hordeum vulgare)
Liliopsida Hv.1444 33
corn
(Zea mays)
Liliopsida Zm.701 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8751 34
  • 60 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU02224 33
  • 53.06 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpn3 33
  • 48.7 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8644 33
Species where no ortholog for PSMD3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMD3 Gene

ENSEMBL:
Gene Tree for PSMD3 (if available)
TreeFam:
Gene Tree for PSMD3 (if available)

Paralogs for PSMD3 Gene

No data available for Paralogs for PSMD3 Gene

Variants for PSMD3 Gene

Sequence variations from dbSNP and Humsavar for PSMD3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000001914 -- 39,994,789(+) TGGAT(A/T)CTATG intron-variant
rs1000113588 -- 39,994,969(+) TTCTC(A/G)TCGTG reference, missense
rs1000235500 -- 39,997,050(+) TCCAC(C/G/T)GGGAA intron-variant
rs1000319285 -- 39,983,011(+) GAGAA(A/G)TGTAG intron-variant
rs1000677681 -- 39,992,197(+) TAACA(C/T)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMD3 Gene

Variant ID Type Subtype PubMed ID
esv3573064 CNV gain 25503493
nsv1146669 OTHER inversion 26484159

Variation tolerance for PSMD3 Gene

Residual Variation Intolerance Score: 12.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 43.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMD3 Gene

Human Gene Mutation Database (HGMD)
PSMD3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD3 Gene

Disorders for PSMD3 Gene

Relevant External Links for PSMD3

Genetic Association Database (GAD)
PSMD3
Human Genome Epidemiology (HuGE) Navigator
PSMD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMD3

No disorders were found for PSMD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMD3 Gene

Publications for PSMD3 Gene

  1. Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1. (PMID: 9017604) Kominami K … Toh-e A (Molecular biology of the cell 1997) 2 3 4 60
  2. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. (PMID: 21738478) Okada Y … Kamatani N (PLoS genetics 2011) 3 45 60
  3. Common variations in PSMD3-CSF3 and PLCB4 are associated with neutrophil count. (PMID: 20172861) Okada Y … Kamatani N (Human molecular genetics 2010) 3 45 60
  4. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for PSMD3 Gene

Sources for PSMD3 Gene