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Aliases for PSMD3 Gene

Aliases for PSMD3 Gene

  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 3 2 3
  • Tissue Specific Transplantation Antigen 2 2 3
  • 26S Proteasome Regulatory Subunit RPN3 3 4
  • 26S Proteasome Regulatory Subunit S3 3 4
  • Proteasome Subunit P58 3 4
  • 26S Proteasome Non-ATPase Regulatory Subunit 3 3
  • TSTA2 3
  • RPN3 3
  • P58 3
  • S3 3

External Ids for PSMD3 Gene

Previous HGNC Symbols for PSMD3 Gene

  • TSTA2

Previous GeneCards Identifiers for PSMD3 Gene

  • GC17M037645
  • GC17P040134
  • GC17P038047
  • GC17P038512
  • GC17P035390
  • GC17P038137
  • GC17P033931

Summaries for PSMD3 Gene

Entrez Gene Summary for PSMD3 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMD3 Gene

PSMD3 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Downstream Signaling Events Of B Cell Receptor (BCR). GO annotations related to this gene include enzyme regulator activity.

UniProtKB/Swiss-Prot for PSMD3 Gene

  • Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins

Gene Wiki entry for PSMD3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD3 Gene

Genomics for PSMD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PSMD3 Gene

Start:
39,980,768 bp from pter
End:
39,997,960 bp from pter
Size:
17,193 bases
Orientation:
Plus strand

Genomic View for PSMD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSMD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD3 Gene

Proteins for PSMD3 Gene

  • Protein details for PSMD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43242-PSMD3_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 3
    Protein Accession:
    O43242
    Secondary Accessions:
    • B3KMW9
    • B4DT72
    • Q96EI2
    • Q9BQA4

    Protein attributes for PSMD3 Gene

    Size:
    534 amino acids
    Molecular mass:
    60978 Da
    Quaternary structure:
    • The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively

    Alternative splice isoforms for PSMD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD3 Gene

Proteomics data for PSMD3 Gene at MOPED

Post-translational modifications for PSMD3 Gene

  • Ubiquitination at Lys54, Lys223, Lys269, Lys273, Lys374, Lys440, Lys461, and Lys492
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMD3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PSMD3 Gene

Domains for PSMD3 Gene

Gene Families for PSMD3 Gene

HGNC:
  • PSM :Proteasome (prosome, macropain) subunits

Graphical View of Domain Structure for InterPro Entry

O43242

UniProtKB/Swiss-Prot:

PSMD3_HUMAN :
  • O43242
Domain:
  • Contains 1 PCI domain.
Family:
  • Belongs to the proteasome subunit S3 family.
genes like me logo Genes that share domains with PSMD3: view

Function for PSMD3 Gene

Molecular function for PSMD3 Gene

UniProtKB/Swiss-Prot Function: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins

Gene Ontology (GO) - Molecular Function for PSMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0030234 enzyme regulator activity IEA --
genes like me logo Genes that share ontologies with PSMD3: view
genes like me logo Genes that share phenotypes with PSMD3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PSMD3 Gene

Localization for PSMD3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMD3 Gene COMPARTMENTS Subcellular localization image for PSMD3 gene
Compartment Confidence
cytosol 4
nucleus 4
cytoskeleton 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PSMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 17323924
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMD3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD3 Gene

Pathways for PSMD3 Gene

SuperPathways for PSMD3 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.38
2 Chks in Checkpoint Regulation
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.62
5 Mitotic Metaphase and Anaphase
genes like me logo Genes that share pathways with PSMD3: view

Gene Ontology (GO) - Biological Process for PSMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSMD3: view

Transcripts for PSMD3 Gene

Unigene Clusters for PSMD3 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMD3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for PSMD3 Gene

GeneLoc Exon Structure for
PSMD3
ECgene alternative splicing isoforms for
PSMD3

Expression for PSMD3 Gene

mRNA expression in normal human tissues for PSMD3 Gene

mRNA differential expression in normal tissues according to GTEx for PSMD3 Gene

This gene is overexpressed in Muscle - Skeletal (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMD3 Gene

SOURCE GeneReport for Unigene cluster for PSMD3 Gene Hs.12970

genes like me logo Genes that share expressions with PSMD3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PSMD3 Gene

Orthologs for PSMD3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMD3 35
  • 99.63 (n)
  • 99.81 (a)
PSMD3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSMD3 35
  • 92.57 (n)
  • 98.5 (a)
PSMD3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMD3 35
  • 92.2 (n)
  • 98.13 (a)
PSMD3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmd3 35
  • 89.31 (n)
  • 96.79 (a)
Psmd3 16
Psmd3 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PSMD3 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMD3 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmd3 35
  • 89.18 (n)
  • 96.6 (a)
chicken
(Gallus gallus)
Aves PSMD3 35
  • 81.63 (n)
  • 90.37 (a)
PSMD3 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMD3 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmd3 35
  • 77.69 (n)
  • 90.35 (a)
Str.15289 35
zebrafish
(Danio rerio)
Actinopterygii psmd3 35
  • 78.98 (n)
  • 88.38 (a)
psmd3 36
  • 86 (a)
OneToOne
zgc65867 35
African malaria mosquito
(Anopheles gambiae)
Insecta PSMD3_ANOGA 35
  • 62.25 (n)
  • 63.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rpn3 35
  • 60.95 (n)
  • 61.39 (a)
Rpn3 36
  • 58 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpn-3 35
  • 50.4 (n)
  • 46.42 (a)
rpn-3 36
  • 43 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR164W 35
  • 48.48 (n)
  • 38.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN3 35
  • 45.58 (n)
  • 36.04 (a)
RPN3 36
  • 31 (a)
OneToOne
RPN3 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D10824g 35
  • 44.13 (n)
  • 37.62 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3192 35
soybean
(Glycine max)
eudicotyledons Gma.5792 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G75990 35
  • 52.57 (n)
  • 46.85 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.1444 35
corn
(Zea mays)
Liliopsida Zm.701 35
rice
(Oryza sativa)
Liliopsida Os.15703 35
Os08g0550100 35
  • 53.01 (n)
  • 50.88 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02224 35
  • 53.06 (n)
  • 47.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpn3 35
  • 48.7 (n)
  • 45.87 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8644 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8751 36
  • 60 (a)
OneToOne
Species with no ortholog for PSMD3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMD3 Gene

ENSEMBL:
Gene Tree for PSMD3 (if available)
TreeFam:
Gene Tree for PSMD3 (if available)

Paralogs for PSMD3 Gene

No data available for Paralogs for PSMD3 Gene

Variants for PSMD3 Gene

Sequence variations from dbSNP and Humsavar for PSMD3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1044248 -- 39,981,149(+) AGCGG(C/T)TGAGC reference, missense
rs2305481 -- 39,982,371(+) GCAGG(A/G)GATAA intron-variant
rs2305482 -- 39,984,674(+) TCTTC(A/C)AAGTC intron-variant
rs2305483 -- 39,986,745(+) ATAAG(A/C)CCCAA intron-variant
rs3087852 -- 39,981,111(-) CCCGT(C/T)GACCC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for PSMD3 Gene

Variant ID Type Subtype PubMed ID
nsv908220 CNV Gain 21882294

Relevant External Links for PSMD3 Gene

HapMap Linkage Disequilibrium report
PSMD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD3 Gene

Disorders for PSMD3 Gene

Relevant External Links for PSMD3

Genetic Association Database (GAD)
PSMD3
Human Genome Epidemiology (HuGE) Navigator
PSMD3
genes like me logo Genes that share disorders with PSMD3: view

No data available for UniProtKB/Swiss-Prot for PSMD3 Gene

Publications for PSMD3 Gene

  1. Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1. (PMID: 9017604) Kominami K. … Toh-e A. (Mol. Biol. Cell 1997) 2 3 4
  2. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X. … Huang L. (Biochemistry 2007) 3 4
  3. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. (PMID: 21738478) Okada Y. … Kamatani N. (PLoS Genet. 2011) 3 48
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PSMD3 Gene

Sources for PSMD3 Gene

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