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Aliases for PSMD3 Gene

Aliases for PSMD3 Gene

  • Proteasome 26S Subunit, Non-ATPase 3 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 3 2 3
  • Tissue Specific Transplantation Antigen 2 2 3
  • 26S Proteasome Regulatory Subunit RPN3 3 4
  • 26S Proteasome Regulatory Subunit S3 3 4
  • Proteasome Subunit P58 3 4
  • 26S Proteasome Non-ATPase Regulatory Subunit 3 3
  • TSTA2 3
  • RPN3 3
  • P58 3
  • S3 3

External Ids for PSMD3 Gene

Previous HGNC Symbols for PSMD3 Gene

  • TSTA2

Previous GeneCards Identifiers for PSMD3 Gene

  • GC17M037645
  • GC17P040134
  • GC17P038047
  • GC17P038512
  • GC17P035390
  • GC17P038137
  • GC17P033931

Summaries for PSMD3 Gene

Entrez Gene Summary for PSMD3 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMD3 Gene

PSMD3 (Proteasome 26S Subunit, Non-ATPase 3) is a Protein Coding gene. Among its related pathways are RET signaling and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include enzyme regulator activity.

UniProtKB/Swiss-Prot for PSMD3 Gene

  • Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

Gene Wiki entry for PSMD3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD3 Gene

Genomics for PSMD3 Gene

Regulatory Elements for PSMD3 Gene

Enhancers for PSMD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F039958 1.2 Ensembl ENCODE 16.1 -21.7 -21695 1.1 PKNOX1 ATF1 ARID4B ZNF48 SLC30A9 ZNF143 MIER2 REST PPARG ZNF592 GSDMA PSMD3 LRRC3C ORMDL3 GSDMB
GH17F039952 1.2 Ensembl ENCODE 11.6 -27.6 -27568 2.4 HDGF WRNIP1 ARID4B ETS1 GLIS2 ZNF263 SP3 YY2 SP5 KAT8 GSDMA GSDMB PSMD3 MED24 GC17M039945
GH17F040086 0.8 ENCODE 10.7 +105.8 105845 0.2 CTCF ARID4B THRB ZNF48 RAD21 PATZ1 ZNF143 SMC3 THAP11 GATAD2A MED24 MIR6884 THRA MSL1 PSMD3 GSDMA LRRC3C ORMDL3 CDC6 GC17P040082
GH17F040031 0.5 ENCODE 11.4 +51.7 51681 2.4 POLR2A HNF4G RAD21 MED24 GSDMA MIR6884 THRA PSMD3 RAPGEFL1 LRRC3C ORMDL3 CDC6 SNORD124
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSMD3 on UCSC Golden Path with GeneCards custom track

Promoters for PSMD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001345843 532 2601 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548

Genomic Location for PSMD3 Gene

39,980,768 bp from pter
39,997,960 bp from pter
17,193 bases
Plus strand

Genomic View for PSMD3 Gene

Genes around PSMD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD3 Gene

Proteins for PSMD3 Gene

  • Protein details for PSMD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 3
    Protein Accession:
    Secondary Accessions:
    • B3KMW9
    • B4DT72
    • Q96EI2
    • Q9BQA4

    Protein attributes for PSMD3 Gene

    534 amino acids
    Molecular mass:
    60978 Da
    Quaternary structure:
    • The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively (By similarity). Interacts with UBQLN1 (via ubiquitin-like domain).

    Three dimensional structures from OCA and Proteopedia for PSMD3 Gene

    Alternative splice isoforms for PSMD3 Gene


neXtProt entry for PSMD3 Gene

Post-translational modifications for PSMD3 Gene

  • Ubiquitination at Lys 54, Lys 223, Lys 269, Lys 273, Lys 374, Lys 440, Lys 461, and Lys 492
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PSMD3 Gene

Domains & Families for PSMD3 Gene

Gene Families for PSMD3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PCI domain.
  • Belongs to the proteasome subunit S3 family.
  • Contains 1 PCI domain.
  • Belongs to the proteasome subunit S3 family.
genes like me logo Genes that share domains with PSMD3: view

Function for PSMD3 Gene

Molecular function for PSMD3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

Gene Ontology (GO) - Molecular Function for PSMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15147878
GO:0030234 enzyme regulator activity IEA --
genes like me logo Genes that share ontologies with PSMD3: view
genes like me logo Genes that share phenotypes with PSMD3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD3 Gene

Localization for PSMD3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMD3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PSMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA,IDA 17323924
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMD3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD3 Gene

Pathways & Interactions for PSMD3 Gene

SuperPathways for PSMD3 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMD3: view

Gene Ontology (GO) - Biological Process for PSMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with PSMD3: view

No data available for SIGNOR curated interactions for PSMD3 Gene

Drugs & Compounds for PSMD3 Gene

(2) Drugs for PSMD3 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 794
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMD3: view

Transcripts for PSMD3 Gene

Unigene Clusters for PSMD3 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: -

Relevant External Links for PSMD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSMD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMD3 Gene

mRNA differential expression in normal tissues according to GTEx for PSMD3 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for PSMD3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMD3 Gene

Protein tissue co-expression partners for PSMD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMD3 Gene:


SOURCE GeneReport for Unigene cluster for PSMD3 Gene:

genes like me logo Genes that share expression patterns with PSMD3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PSMD3 Gene

Orthologs for PSMD3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PSMD3 34 35
  • 99.63 (n)
(Monodelphis domestica)
Mammalia PSMD3 35
  • 94 (a)
(Bos Taurus)
Mammalia PSMD3 34 35
  • 92.57 (n)
(Canis familiaris)
Mammalia PSMD3 34 35
  • 92.2 (n)
(Mus musculus)
Mammalia Psmd3 34 16 35
  • 89.31 (n)
(Rattus norvegicus)
Mammalia Psmd3 34
  • 89.18 (n)
(Ornithorhynchus anatinus)
Mammalia PSMD3 35
  • 76 (a)
(Gallus gallus)
Aves PSMD3 34 35
  • 81.63 (n)
(Anolis carolinensis)
Reptilia PSMD3 35
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia psmd3 34
  • 77.69 (n)
Str.15289 34
(Danio rerio)
Actinopterygii psmd3 34 35
  • 78.98 (n)
zgc65867 34
African malaria mosquito
(Anopheles gambiae)
Insecta PSMD3_ANOGA 34
  • 62.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rpn3 34 35
  • 60.95 (n)
(Caenorhabditis elegans)
Secernentea rpn-3 34 35
  • 50.4 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR164W 34
  • 48.48 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN3 34 35 37
  • 45.58 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D10824g 34
  • 44.13 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G75990 34
  • 52.57 (n)
(Glycine max)
eudicotyledons Gma.5792 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3192 34
(Oryza sativa)
Liliopsida Os08g0550100 34
  • 53.01 (n)
Os.15703 34
(Hordeum vulgare)
Liliopsida Hv.1444 34
(Zea mays)
Liliopsida Zm.701 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8751 35
  • 60 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02224 34
  • 53.06 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpn3 34
  • 48.7 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8644 34
Species where no ortholog for PSMD3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMD3 Gene

Gene Tree for PSMD3 (if available)
Gene Tree for PSMD3 (if available)

Paralogs for PSMD3 Gene

No data available for Paralogs for PSMD3 Gene

Variants for PSMD3 Gene

Sequence variations from dbSNP and Humsavar for PSMD3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1044248 -- 39,981,149(+) AGCGG(C/T)TGAGC reference, missense
rs1062816 -- 39,997,713(+) GGGTG(C/T)TGGGA utr-variant-3-prime
rs10671123 -- 39,997,461(+) GGGCT(-/GA)GAGCT intron-variant
rs11078929 -- 39,983,981(+) GATCA(C/G)GAGGT intron-variant
rs11078930 -- 39,985,702(+) AACTC(C/T)ACCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMD3 Gene

Variant ID Type Subtype PubMed ID
esv3573064 CNV gain 25503493
nsv1146669 OTHER inversion 26484159

Variation tolerance for PSMD3 Gene

Residual Variation Intolerance Score: 12.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 43.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD3 Gene

Disorders for PSMD3 Gene

Relevant External Links for PSMD3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PSMD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMD3 Gene

Publications for PSMD3 Gene

  1. Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1. (PMID: 9017604) Kominami K. … Toh-e A. (Mol. Biol. Cell 1997) 2 3 4 64
  2. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. (PMID: 21738478) Okada Y. … Kamatani N. (PLoS Genet. 2011) 3 46 64
  3. Common variations in PSMD3-CSF3 and PLCB4 are associated with neutrophil count. (PMID: 20172861) Okada Y. … Kamatani N. (Hum. Mol. Genet. 2010) 3 46 64
  4. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X. … Huang L. (Biochemistry 2007) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for PSMD3 Gene

Sources for PSMD3 Gene