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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PSMD3 Gene

protein-coding   GIFtS: 57
GCID: GC17P038137

proteasome (prosome, macropain) 26S subunit, non-ATPase,...

(Previous name: tissue specific transplantation antigen 2 )
(Previous symbol: TSTA2)
 Explore 5 diseases affiliated with
PSMD3 via our new
 Human Malady Compendium 
Biological research products
for PSMD3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 31 2     26S Proteasome Regulatory Subunit RPN32 3
P581 2     26S Proteasome Regulatory Subunit S32 3
S31 2     Rpn31
TSTA21 2     26S Proteasome Non-ATPase Regulatory Subunit 32
Tissue Specific Transplantation Antigen 21 2     RPN32
Proteasome Subunit P582 3     

External Ids:    HGNC: 95601   Entrez Gene: 57092   Ensembl: ENSG000001083447   UniProtKB: O432423   

Export aliases for PSMD3 gene to outside databases

Previous GC identifers: GC17M037645 GC17P040134 GC17P038047 GC17P038512 GC17P035390 GC17P033931


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PSMD3:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a
20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed
of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which
contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits.
Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an
ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3
family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in
this gene are associated with neutrophil count. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: PSMD3_HUMAN, O43242
Function: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of
ubiquitinated proteins

Gene Wiki entry for PSMD3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PSMD3 gene promoter:
         Elk-1   NRSF form 1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   NRSF form 2   POU3F2   PPAR-alpha   POU2F1   POU2F1a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PSMD3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PSMD3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSMD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.1   Ensembl cytogenetic band:  17q21.1   HGNC cytogenetic band: 17q21.2

PSMD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMD3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P038137:  view genomic region     (about GC identifiers)

Start:
38,137,050 bp from pter      End:
38,154,213 bp from pter
Size:
17,164 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PSMD3_HUMAN, O43242 (See protein sequence)
Recommended Name: 26S proteasome non-ATPase regulatory subunit 3  
Size: 534 amino acids; 60978 Da
Subunit: The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by
the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base
and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively
Secondary accessions: B3KMW9 Q96EI2 Q9BQA4

Explore the universe of human proteins at neXtProt for PSMD3: NX_O43242

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43242

  • PSMD3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002800.2  
    ENSEMBL proteins: 
     ENSP00000264639   ENSP00000407410   ENSP00000444980   ENSP00000442508  
    Reactome Protein details: O43242
    Human Recombinant Protein Products: 
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    Uscn Proteins for PSMD3

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex TAS8811196
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0022624proteasome accessory complex ISS--


    PSMD3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PSMD3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PSMD3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011990 TPR-like_helical
     IPR013586 26S_Psome_reg_C
     IPR013143 PAM
     IPR000717 PCI_dom
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry O43242

    ProtoNet protein and cluster: O43242

    2 Blocks protein families:
    IPB000717 Domain in components of the proteasome
    IPB013586 26S proteasome regulatory subunit


    UniProtKB/Swiss-Prot: PSMD3_HUMAN, O43242
    Similarity: Belongs to the proteasome subunit S3 family
    Similarity: Contains 1 PCI domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PSMD3_HUMAN, O43242
    Function: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of
    ubiquitinated proteins

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidPSMD3 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030234enzyme regulator activity IEA--


    PSMD3 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for PSMD3:
     Abundance of large cells with   Decreased Hepatitis C virus re  Decreased cell number, increas  Decreased homologous recombina 
     Decreased viability with pacli  Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/29 super-pathways (see all 29About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitinated Orc1 is degraded by the proteasome
    8/78 pathways (see all 78)
    Ubiquitinated Orc1 is degraded by the proteasome1.00
    Degradation of ubiquitinated p27/p21 by the 26S proteasome0.75
    Proteasomal cleavage of substrate0.98
    SCF(Skp2)-mediated degradation of p27/p210.75
    Proteasome mediated degradation of PAK-2p340.98
    APC/C:Cdh1-mediated degradation of Skp20.74
    Proteasomal cleavage of substrate0.98
    APC/C:Cdc20 mediated degradation of Securin0.74
    2M Phase
    M Phase1.00
    Mitotic Anaphase0.85
    Mitotic M-M/G1 phases0.88
    Separation of Sister Chromatids0.80
    Mitotic Metaphase and Anaphase0.85
    3Chks in Checkpoint Regulation
    Chks in Checkpoint Regulation1.00
    p53 Signaling0.32
    G2-M Phase Transition0.59
    DNA Repair Mechanisms0.32
    Estrogen-mediated S-Phase Entry0.55
    4HIV Infection
    HIV Infection1.00
    Transcription_Ligand-Dependent Transcription of Retinoid-Target genes0.28
    Host Interactions of HIV factors0.64
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes0.28
    5Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway1.00
    Parkin-Ubiquitin Proteasomal System pathway0.93
    Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for PSMD3
        Immune response Antigen presentation by MHC class I
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

    5/19 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PSMD3 (see all 19)
        Remodeling of Adherens Junctions
    CDK5 Pathway
    Estrogen-mediated S-Phase Entry
    G2-M Phase Transition
    DNA Repair Mechanisms

    3 GeneGo (Thomson Reuters) Pathways for PSMD3
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Antigen presentation by MHC class I

    3 BioSystems Pathways for PSMD3 
        Parkin-Ubiquitin Proteasomal System pathway
    Proteasome Degradation
    TNF-alpha/NF-kB Signaling Pathway

    5/98        Reactome Pathways for PSMD3 (see all 98)
        Ubiquitinated geminin is degraded by the proteasome
    Proteolytic degradation of ubiquitinated-Cdc25A
    Orc1 removal from chromatin
    CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway


    1         Kegg Pathway  (Kegg details for PSMD3):
        Proteasome


    PSMD3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PSMD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/992 Interacting proteins for PSMD3 (O432422, 3 ENSP000002646394) via UniProtKB, MINT, STRING, and/or I2D (see all 992)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000084S phase of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000216M/G1 transition of mitotic cell cycle TAS--


    PSMD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PSMD3
    Search CenterWatch for drugs/clinical trials and news about PSMD3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PSMD3 gene: 
    NM_002809.3  

    Unigene Cluster for PSMD3:

    Proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
    Hs.12970  [show with all ESTs]
    Unigene Representative Sequence: NM_002809
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264639(uc002htn.1 uc010wen.1 uc010weo.1) ENST00000415039
    ENST00000540504 ENST00000580980 ENST00000485835 ENST00000541736

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate PSMD3:
    hsa-miR-2355-5p hsa-miR-146a hsa-miR-3613-3p hsa-miR-548c-3p hsa-miR-146b-5p hsa-miR-504
    SwitchGear 3'UTR luciferase reporter plasmidPSMD3 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF091075.1 AK022896.1 AK054611.1 AK055799.1 AK094206.1 AK293539.1 AK298411.1 AK300081.1 
    AK300973.1 BC000074.2 BC004859.2 BC012302.1 BC020518.1 BC025686.1 BT007217.1 CR456772.1 
    D67025.1 

    24/31 DOTS entries (see all 31):

    DT.100669344  DT.91773787  DT.454632  DT.100669339  DT.100669353  DT.100669351  DT.100669350  DT.91773779 
    DT.100669340  DT.100729219  DT.120997212  DT.100056796  DT.95274029  DT.120997295  DT.120997308  DT.97821236 
    DT.120997303  DT.120997313  DT.91773775  DT.91773796  DT.95274048  DT.100653203  DT.100849063  DT.120997220 

    24/756 AceView cDNA sequences (see all 756):

    CF131393 BG752835 AA653252 AK055799 BX367052 BG396862 BG422089 BF912604 
    BQ070822 AA255870 BX397579 NM_002809 AU124516 BQ685956 AW732940 AL537979 
    AW630318 BX371821 AU102316 BQ063367 BM717173 BU184065 BX410263 AA262120 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PSMD3 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                                                                            -               
    SP2:                                                                                                            
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for PSMD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PSMD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGTTTCCTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See PSMD3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PSMD3

    SOURCE GeneReport for Unigene cluster: Hs.12970
        SABiosciences Custom PCR Arrays for PSMD3
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PSMD3 gene from 10/40 species (see all 40)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Psmd31 , 5 proteasome (prosome, macropain) 26S subunit, non-ATPase, more1, 5 90(n)1
    98.11(a)1
      11 (62.39 cM)5
    221231  NM_009439.11  NP_033465.11 
     986825545 
    chicken
    (Gallus gallus)
    Aves PSMD31 proteasome (prosome, macropain) 26S subunit, non-ATPase, more 82.15(n)
    90.94(a)
      426133  NM_001031362.1  NP_001026533.1 
    lizard
    (Anolis carolinensis)
    Reptilia PSMD36
    --
    91(a)
    1 ↔ 1
    6(68930548-68943700)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF290648.12   -- 79.77(n)    CF290648.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc658672 hypothetical protein MGC65867 80.3(n)   393544  BC056598.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rpn31 Regulatory particle non-ATPase 3 59.27(n)
    58.11(a)
      35176  NM_057952.3  NP_477300.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rpn-31 Protein RPN-3 50(n)
    45.59(a)
      176196  NM_066468.3  NP_498869.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPN3(YER021W)4
    RPN31
    Essential, non-ATPase regulatory subunit of the 26S more4
    Rpn3p1
    44.18(n)1
    33.83(a)1
      5(196948-198519)4
    8567421, 4  NP_010938.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EMB27191 26S proteasome regulatory subunit N3 51.45(n)
    46.47(a)
      838609  NM_101873.2  NP_173447.1 
    rice
    (Oryza sativa)
    Liliopsida Os.157032 Oryza sativa (japonica cultivar-group) Os21D7 mRNA, more 73.92(n)    AK059017.1 


    ENSEMBL Gene Tree for PSMD3 (if available)
    TreeFam Gene Tree for PSMD3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/388 NCBI SNPs in PSMD3 are shown (see all 388    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs99090191,2
    C,F,--33940632(+) GCCTGG/ACCCCT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs80805461,2
    C,F,H,--33940985(+) CCCAGC/AGCTCC 1 -- us2k119Minor allele frequency- A:0.15NS EA NA WA CSA 2144
    rs752177651,2
    --33941035(+) CAAACC/GCCAGG 1 -- us2k12Minor allele frequency- G:0.17CSA WA 120
    rs169654951,2
    C,F,--33941142(+) ATAAAA/GCTTGG 1 -- us2k16Minor allele frequency- G:0.02NA WA CSA 148
    rs1127290881,2
    --33942076(+) GGAGGC/TTGTGG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs766879931,2
    C,--33943233(+) CGCTCG/ACCTGC 1 -- nc-transcript-variant2Minor allele frequency- A:0.17CSA WA 120
    rs582123531,2
    C,F,--33943277(+) GTTACT/GCTGCT 1 -- nc-transcript-variant5Minor allele frequency- G:0.20WA NA CSA 244
    rs732972421,2
    C,--33944362(+) GACTCC/TTTAAG 1 -- ds50012Minor allele frequency- T:0.05WA 120
    rs775324451,2
    --33944384(+) ATTAAC/GCATTT 1 -- ds50010--------
    rs733012251,2
    C,--33944675(+) GTCCTG/ATAGAG 1 -- ds50011Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for PSMD3 (38137050 - 38154213 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PSMD3: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PSMD3
    DNA2.0 Custom Variant and Variant Library Synthesis for PSMD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PSMD3 for disorders           About GeneDecksing

    5 diseases for PSMD3:    About MalaCards
    myeloma    immunodeficiency    malaria    huntington's disease
    parkinson's disease

    Human Genome Epidemiology (HuGE) Navigator: PSMD3 (1 document)

    Export disorders for PSMD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PSMD3 gene, integrated from 9 sources (see all 71):
    (articles sorted by number of sources associating them with PSMD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1. (PubMed id 9017604)1, 2, 3 Kominami K.... Toh-e A. (1997)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    6. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    7. Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network. (PubMed id 22037903)1 Crosslin D.R....Jarvik G.P. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5709 HGNC: 9560 AceView: PSMD3 Ensembl:ENSG00000108344 euGenes: HUgn5709
    ECgene: PSMD3 Kegg: 5709 H-InvDB: PSMD3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PSMD3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PSMD3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PSMD3 gene:
    Search GeneIP for patents involving PSMD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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