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PSMD3 Gene

protein-coding   GIFtS: 61
GCID: GC17P038137

Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase,...

(Previous name: tissue specific transplantation antigen 2)
(Previous symbol: TSTA2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 31 2     26S Proteasome Regulatory Subunit S32 3
TSTA21 2     26S Proteasome Non-ATPase Regulatory Subunit 32
Tissue Specific Transplantation Antigen 21 2     P582
Proteasome Subunit P582 3     RPN32
26S Proteasome Regulatory Subunit RPN32 3     S32

External Ids:    HGNC: 95601   Entrez Gene: 57092   Ensembl: ENSG000001083447   UniProtKB: O432423   

Export aliases for PSMD3 gene to outside databases

Previous GC identifers: GC17M037645 GC17P040134 GC17P038047 GC17P038512 GC17P035390 GC17P033931


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PSMD3 Gene:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes,
a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are
composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a
base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in
an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome
subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide
polymorphisms in this gene are associated with neutrophil count. (provided by RefSeq, Jul 2012)

GeneCards Summary for PSMD3 Gene:
PSMD3 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 3) is a protein-coding gene. GO annotations related to this gene include enzyme regulator activity.

UniProtKB/Swiss-Prot: PSMD3_HUMAN, O43242
Function: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of
ubiquitinated proteins

Gene Wiki entry for PSMD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PSMD3 gene promoter:
         Elk-1   NRSF form 1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   NRSF form 2   POU3F2   PPAR-alpha   POU2F1   POU2F1a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PSMD3 promoter sequence
   Search Chromatin IP Primers for PSMD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSMD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.1   Ensembl cytogenetic band:  17q21.1   HGNC cytogenetic band: 17q21.2

PSMD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMD3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P038137:  view genomic region     (about GC identifiers)

Start:
38,137,050 bp from pter      End:
38,154,213 bp from pter
Size:
17,164 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PSMD3_HUMAN, O43242 (See protein sequence)
Recommended Name: 26S proteasome non-ATPase regulatory subunit 3  
Size: 534 amino acids; 60978 Da
Subunit: The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both
ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two
subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core,
respectively
Secondary accessions: B3KMW9 Q96EI2 Q9BQA4

Explore the universe of human proteins at neXtProt for PSMD3: NX_O43242

Explore proteomics data for PSMD3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys54, Lys223, Lys269, Lys273, Lys374, Lys440, Lys461, Lys492
  • Modification sites at PhosphoSitePlus

  • See PSMD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002800.2  
    ENSEMBL proteins: 
     ENSP00000264639   ENSP00000407410   ENSP00000444980   ENSP00000442508  
    Reactome Protein details: O43242

    PSMD3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PSMD3

     
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    antibodies-online proteins for PSMD3 (7 products) 

     
    antibodies-online peptides for PSMD3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PSM: Proteasome (prosome, macropain) subunits

    5 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR013586 26S_Psome_reg_C
     IPR013143 PAM
     IPR000717 PCI_dom
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry O43242

    ProtoNet protein and cluster: O43242

    2 Blocks protein domains:
    IPB000717 Domain in components of the proteasome
    IPB013586 26S proteasome regulatory subunit


    UniProtKB/Swiss-Prot: PSMD3_HUMAN, O43242
    Similarity: Belongs to the proteasome subunit S3 family
    Similarity: Contains 1 PCI domain


    Find genes that share domains with PSMD3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PSMD3_HUMAN, O43242
    Function: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of
    ubiquitinated proteins

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0030234enzyme regulator activity IEA--
         
    Find genes that share ontologies with PSMD3           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for PSMD3:
     Abundance of large cells with   Decreased Hepatitis C virus re  Decreased cell number, increas  Decreased homologous recombina 
     Decreased viability with pacli  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PSMD3

    miRNA
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    miRTarBase miRNAs that target PSMD3:
    hsa-mir-92b-3p (MIRT040625), hsa-mir-186-5p (MIRT045113), hsa-mir-769-5p (MIRT039148), hsa-mir-92a-3p (MIRT049247), hsa-mir-760 (MIRT036722), hsa-mir-378a-5p (MIRT044009)

    Block miRNA regulation of human, mouse, rat PSMD3 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate PSMD3:
    hsa-miR-2355-5p hsa-miR-146a hsa-miR-3613-3p hsa-miR-548c-3p hsa-miR-146b-5p hsa-miR-504
    SwitchGear 3'UTR luciferase reporter plasmidPSMD3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PSMD3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: PSMD3 (NM_002809)
    Sino Biological Human cDNA Clone for PSMD3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMD3

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    cytoskeleton1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex TAS8811196
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with PSMD3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PSMD3 About   (see all 30)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    CDK-mediated phosphorylation and removal of Cdc60.94
    Destabilization of mRNA by AUF1 (hnRNP D0)0.88
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    G1/S DNA Damage Checkpoints0.87
    Ubiquitin-dependent degradation of Cyclin D10.94
    CDT1 association with the CDC6-ORC-origin complex0.87
    Ubiquitin-dependent degradation of Cyclin D0.94
    SCF(Skp2)-mediated degradation of p27/p210.86
    2Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Chks in Checkpoint Regulation
    Chks in Checkpoint Regulation0.59
    SREBP Proteolysis0.43
    G2-M Phase Transition0.59
    DNA Repair Mechanisms0.32
    Estrogen-mediated S-Phase Entry0.55
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90


    Find genes that share SuperPaths with PSMD3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PSMD3 (see all 19)
        Remodeling of Adherens Junctions
    CDK5 Pathway
    Estrogen-mediated S-Phase Entry
    G2-M Phase Transition
    DNA Repair Mechanisms

    3 GeneGo (Thomson Reuters) Pathways for PSMD3
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Antigen presentation by MHC class I

    3 BioSystems Pathways for PSMD3
        Parkin-Ubiquitin Proteasomal System pathway
    Proteasome Degradation
    TNF-alpha/NF-kB Signaling Pathway


    Selected Reactome Pathways for PSMD3 (see all 24)
        SCF(Skp2)-mediated degradation of p27/p21
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
    SCF-beta-TrCP mediated degradation of Emi1
    Ubiquitin-dependent degradation of Cyclin D1
    Orc1 removal from chromatin


    2 Kegg Pathways  (Kegg details for PSMD3):
        Proteasome
    Epstein-Barr virus infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PSMD3
    Interactions:

        GeneGlobe Interaction Network for PSMD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PSMD3 (O432422, 3 ENSP000002646394) via UniProtKB, MINT, STRING, and/or I2D (see all 1077)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--

    Find genes that share ontologies with PSMD3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PSMD3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PSMD3 gene: 
    NM_002809.3  

    Unigene Cluster for PSMD3:

    Proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
    Hs.12970  [show with all ESTs]
    Unigene Representative Sequence: NM_002809
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264639(uc002htn.1 uc010wen.1 uc010weo.1) ENST00000415039
    ENST00000540504 ENST00000580980 ENST00000485835 ENST00000541736
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate PSMD3:
    hsa-miR-2355-5p hsa-miR-146a hsa-miR-3613-3p hsa-miR-548c-3p hsa-miR-146b-5p hsa-miR-504
    SwitchGear 3'UTR luciferase reporter plasmidPSMD3 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PSMD3
      QuantiFast Probe-based Assays in human, mouse, rat PSMD3

    Additional mRNA sequence: 

    AF091075.1 AK022896.1 AK054611.1 AK055799.1 AK094206.1 AK293539.1 AK298411.1 AK300081.1 
    AK300973.1 BC000074.2 BC004859.2 BC012302.1 BC020518.1 BC025686.1 BT007217.1 CR456772.1 
    D67025.1 

    Selected DOTS entries (see all 31):

    DT.100669344  DT.91773787  DT.454632  DT.100669339  DT.100669353  DT.100669351  DT.100669350  DT.91773779 
    DT.100669340  DT.100729219  DT.120997212  DT.100056796  DT.95274029  DT.120997295  DT.120997308  DT.97821236 
    DT.120997303  DT.120997313  DT.91773775  DT.91773796  DT.95274048  DT.100653203  DT.100849063  DT.120997220 

    Selected AceView cDNA sequences (see all 756):

    BQ063367 BQ428328 BM701386 AU141328 BQ222718 BF094529 BQ637938 BU196511 
    AA447066 BP340612 BU179102 AA262120 AW732940 BF797183 BQ233895 AK022896 
    BE336738 BQ883576 BM475593 BM841034 CB153933 BP371271 BU184065 CF131393 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PSMD3 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                                                                            -               
    SP2:                                                                                                            
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for PSMD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PSMD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTTTCCTC
    PSMD3 Expression
    About this image

    PSMD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PSMD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.12970
        Custom PCR Arrays for PSMD3
    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PSMD3 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Psmd31 , 5 proteasome (prosome, macropain) 26S subunit, non-ATPase, more1, 5 89.31(n)1
    96.79(a)1
      11 (62.39 cM)5
    221231  NM_009439.11  NP_033465.11 
     986825545 
    chicken
    (Gallus gallus)
    Aves PSMD31 proteasome (prosome, macropain) 26S subunit, non-ATPase, more 81.63(n)
    90.37(a)
      426133  NM_001031362.1  NP_001026533.1 
    lizard
    (Anolis carolinensis)
    Reptilia PSMD36
    proteasome (prosome, macropain) 26S subunit, non-A...
    89(a)
    1 ↔ 1
    6(68929981-68944676)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF290648.12   -- 79.77(n)    CF290648.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc658672 hypothetical protein MGC65867 80.3(n)   393544  BC056598.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rpn31 Regulatory particle non-ATPase 3 60.95(n)
    61.39(a)
      35176  NM_057952.4  NP_477300.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rpn-31 rpn-3 50.4(n)
    46.42(a)
      176196  NM_066468.4  NP_498869.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPN3(YER021W)4
    RPN31
    Essential, non-ATPase regulatory subunit of the 26S more4
    RPN31
    45.58(n)1
    36.04(a)1
      5(196948-198519)4
    8567421, 4  NP_010938.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G759901 AT1G75990 52.57(n)
    46.85(a)
      843931  NM_106248.3  NP_177726.1 
    rice
    (Oryza sativa)
    Liliopsida Os.157032 Oryza sativa (japonica cultivar-group) Os21D7 mRNA, more 73.92(n)    AK059017.1 


    ENSEMBL Gene Tree for PSMD3 (if available)
    TreeFam Gene Tree for PSMD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for PSMD3 (see all 395)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs711526351,2
    C--33948332(-) GCAGA-/CC    
       CATCG
    CCCTC
    1 -- ds50011Minor allele frequency- CCCATCG:0.00NA 2
    rs351531661,2
    C,F--38135092(+) AAATT-/AAAAAA 1 -- us2k13Minor allele frequency- A:0.33NA CSA 6
    rs1830477251,2
    --38135092(+) AAATTA/TAAAAA 1 -- us2k10--------
    rs1878726701,2
    --38135132(+) GGCTCA/GCACCT 1 -- us2k10--------
    rs1455979821,2
    --38135349(+) GTCACC/TCCCTG 1 -- us2k10--------
    rs1926415131,2
    --38135519(+) GTGATA/GTAAAC 1 -- us2k10--------
    rs1484636461,2
    --38135560(+) ATCTAC/GAAGAG 1 -- us2k10--------
    rs1822327851,2
    --38135793(+) TCCAGG/TTAGCG 1 -- us2k10--------
    rs1460129211,2
    C--38135805(+) TGGCT-/GGTTTA 1 -- us2k10--------
    rs98985471,2
    C,F,H--38136026(+) TTGTTT/GTGTGT 1 -- us2k113Minor allele frequency- G:0.49NA WA CSA EA 376

    HapMap Linkage Disequilibrium report for PSMD3 (38137050 - 38154213 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PSMD3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908220CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PSMD3
    DNA2.0 Custom Variant and Variant Library Synthesis for PSMD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with PSMD3           About GenesLikeMe

    Genetic Association Database (GAD): PSMD3
    Human Genome Epidemiology (HuGE) Navigator: PSMD3 (1 document)

    Export disorders for PSMD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PSMD3 gene, integrated from 10 sources (see all 86):
    (articles sorted by number of sources associating them with PSMD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1. (PubMed id 9017604)1, 2, 3 Kominami K.... Toh-e A. (Mol. Biol. Cell 1997)
    2. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. (PubMed id 21738478)1, 4 Okada Y....Kamatani N. (PLoS Genet. 2011)
    3. Common variations in PSMD3-CSF3 and PLCB4 are associated with neutrophil count. (PubMed id 20172861)1, 4 Okada Y....Kamatani N. (Hum. Mol. Genet. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response. (PubMed id 23751493)1 Poulsen S.L....Mailand N. (J. Cell Biol. 2013)
    8. Genetic variants at PSMD3 interact with dietary fat and carbohydrate to modulate insulin resistance. (PubMed id 23303871)1 Zheng J.S....Lai C.Q. (J. Nutr. 2013)
    9. Proteomic analysis of the NOS2 interactome in human airway epithelial cells. (PubMed id 23438482)1 Foster M.W....Marshall H.E. (Nitric Oxide 2013)
    10. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5709 HGNC: 9560 AceView: PSMD3 Ensembl:ENSG00000108344 euGenes: HUgn5709
    ECgene: PSMD3 Kegg: 5709 H-InvDB: PSMD3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PSMD3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PSMD3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PSMD3 gene:
    Search GeneIP for patents involving PSMD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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