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Aliases for PSMD3 Gene

Aliases for PSMD3 Gene

  • Proteasome 26S Subunit, Non-ATPase 3 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 3 2 3
  • Tissue Specific Transplantation Antigen 2 2 3
  • 26S Proteasome Regulatory Subunit RPN3 3 4
  • 26S Proteasome Regulatory Subunit S3 3 4
  • Proteasome Subunit P58 3 4
  • TSTA2 3
  • RPN3 3
  • P58 3
  • S3 3

External Ids for PSMD3 Gene

Previous HGNC Symbols for PSMD3 Gene

  • TSTA2

Previous GeneCards Identifiers for PSMD3 Gene

  • GC17M037645
  • GC17P040134
  • GC17P038047
  • GC17P038512
  • GC17P035390
  • GC17P038137
  • GC17P033931

Summaries for PSMD3 Gene

Entrez Gene Summary for PSMD3 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMD3 Gene

PSMD3 (Proteasome 26S Subunit, Non-ATPase 3) is a Protein Coding gene. Among its related pathways are Cell Cycle Checkpoints and Mitotic Metaphase and Anaphase. GO annotations related to this gene include enzyme regulator activity.

UniProtKB/Swiss-Prot for PSMD3 Gene

  • Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

Gene Wiki entry for PSMD3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD3 Gene

Genomics for PSMD3 Gene

Regulatory Elements for PSMD3 Gene

Enhancers for PSMD3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSMD3 on UCSC Golden Path with GeneCards custom track

Promoters for PSMD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSMD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSMD3 Gene

39,980,768 bp from pter
39,997,960 bp from pter
17,193 bases
Plus strand

Genomic View for PSMD3 Gene

Genes around PSMD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD3 Gene

Proteins for PSMD3 Gene

  • Protein details for PSMD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 3
    Protein Accession:
    Secondary Accessions:
    • B3KMW9
    • B4DT72
    • Q96EI2
    • Q9BQA4

    Protein attributes for PSMD3 Gene

    534 amino acids
    Molecular mass:
    60978 Da
    Quaternary structure:
    • The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively (By similarity). Interacts with UBQLN1 (via ubiquitin-like domain).

    Alternative splice isoforms for PSMD3 Gene


neXtProt entry for PSMD3 Gene

Proteomics data for PSMD3 Gene at MOPED

Post-translational modifications for PSMD3 Gene

  • Ubiquitination at Lys 54, Lys 223, Lys 269, Lys 273, Lys 374, Lys 440, Lys 461, and Lys 492
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PSMD3 Gene

Domains & Families for PSMD3 Gene

Gene Families for PSMD3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PCI domain.
  • Belongs to the proteasome subunit S3 family.
  • Contains 1 PCI domain.
  • Belongs to the proteasome subunit S3 family.
genes like me logo Genes that share domains with PSMD3: view

Function for PSMD3 Gene

Molecular function for PSMD3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
genes like me logo Genes that share phenotypes with PSMD3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD3 Gene

Localization for PSMD3 Gene

Subcellular locations from

Jensen Localization Image for PSMD3 Gene COMPARTMENTS Subcellular localization image for PSMD3 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PSMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PSMD3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD3 Gene

Pathways & Interactions for PSMD3 Gene

SuperPathways for PSMD3 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 Interleukin-3, 5 and GM-CSF signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
5 Immune System
genes like me logo Genes that share pathways with PSMD3: view

Gene Ontology (GO) - Biological Process for PSMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSMD3: view

No data available for SIGNOR curated interactions for PSMD3 Gene

Drugs & Compounds for PSMD3 Gene

(2) Drugs for PSMD3 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 776
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMD3: view

Transcripts for PSMD3 Gene

Unigene Clusters for PSMD3 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: -

Relevant External Links for PSMD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSMD3 Gene

mRNA expression in normal human tissues for PSMD3 Gene

mRNA differential expression in normal tissues according to GTEx for PSMD3 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for PSMD3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMD3 Gene

SOURCE GeneReport for Unigene cluster for PSMD3 Gene Hs.12970

genes like me logo Genes that share expression patterns with PSMD3: view

Protein tissue co-expression partners for PSMD3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PSMD3 Gene

Orthologs for PSMD3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PSMD3 35
  • 92.57 (n)
  • 98.5 (a)
PSMD3 36
  • 98 (a)
(Canis familiaris)
Mammalia PSMD3 35
  • 92.2 (n)
  • 98.13 (a)
PSMD3 36
  • 98 (a)
(Mus musculus)
Mammalia Psmd3 35
  • 89.31 (n)
  • 96.79 (a)
Psmd3 16
Psmd3 36
  • 97 (a)
(Pan troglodytes)
Mammalia PSMD3 35
  • 99.63 (n)
  • 99.81 (a)
PSMD3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Psmd3 35
  • 89.18 (n)
  • 96.6 (a)
(Monodelphis domestica)
Mammalia PSMD3 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia PSMD3 36
  • 76 (a)
(Gallus gallus)
Aves PSMD3 35
  • 81.63 (n)
  • 90.37 (a)
PSMD3 36
  • 94 (a)
(Anolis carolinensis)
Reptilia PSMD3 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia psmd3 35
  • 77.69 (n)
  • 90.35 (a)
Str.15289 35
(Danio rerio)
Actinopterygii psmd3 35
  • 78.98 (n)
  • 88.38 (a)
zgc65867 35
psmd3 36
  • 86 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta PSMD3_ANOGA 35
  • 62.25 (n)
  • 63.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rpn3 35
  • 60.95 (n)
  • 61.39 (a)
Rpn3 36
  • 58 (a)
(Caenorhabditis elegans)
Secernentea rpn-3 35
  • 50.4 (n)
  • 46.42 (a)
rpn-3 36
  • 43 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR164W 35
  • 48.48 (n)
  • 38.22 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D10824g 35
  • 44.13 (n)
  • 37.62 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN3 35
  • 45.58 (n)
  • 36.04 (a)
RPN3 36
  • 31 (a)
RPN3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G75990 35
  • 52.57 (n)
  • 46.85 (a)
(Glycine max)
eudicotyledons Gma.5792 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3192 35
(Hordeum vulgare)
Liliopsida Hv.1444 35
(Oryza sativa)
Liliopsida Os.15703 35
Os08g0550100 35
  • 53.01 (n)
  • 50.88 (a)
(Zea mays)
Liliopsida Zm.701 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8644 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02224 35
  • 53.06 (n)
  • 47.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpn3 35
  • 48.7 (n)
  • 45.87 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8751 36
  • 60 (a)
Species with no ortholog for PSMD3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMD3 Gene

Gene Tree for PSMD3 (if available)
Gene Tree for PSMD3 (if available)

Paralogs for PSMD3 Gene

No data available for Paralogs for PSMD3 Gene

Variants for PSMD3 Gene

Sequence variations from dbSNP and Humsavar for PSMD3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1044248 -- 39,981,149(+) AGCGG(C/T)TGAGC reference, missense
rs2305481 -- 39,982,371(+) GCAGG(A/G)GATAA intron-variant
rs2305482 -- 39,984,674(+) TCTTC(A/C)AAGTC intron-variant
rs2305483 -- 39,986,745(+) ATAAG(A/C)CCCAA intron-variant
rs3087852 -- 39,981,111(-) CCCGT(C/T)GACCC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PSMD3 Gene

Variant ID Type Subtype PubMed ID
nsv908220 CNV Gain 21882294

Variation tolerance for PSMD3 Gene

Residual Variation Intolerance Score: 12.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 43.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PSMD3 Gene

Disorders for PSMD3 Gene

Relevant External Links for PSMD3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PSMD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMD3 Gene

Publications for PSMD3 Gene

  1. Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1. (PMID: 9017604) Kominami K. … Toh-e A. (Mol. Biol. Cell 1997) 2 3 4 67
  2. Genome-wide association study identifies a PSMD3 variant associated with neutropenia in interferon-based therapy for chronic hepatitis C. (PMID: 25515861) Iio E. … Tanaka Y. (Hum. Genet. 2015) 3
  3. DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. (PMID: 25756610) Papp S.J. … Lamia K.A. (Elife 2015) 3
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for PSMD3 Gene

Sources for PSMD3 Gene