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Aliases for PSMD2 Gene

Aliases for PSMD2 Gene

  • Proteasome 26S Subunit, Non-ATPase 2 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 2 2 3
  • Tumor Necrosis Factor Type 1 Receptor-Associated Protein 2 3 4
  • Protein 55.11 3 4
  • TRAP2 3 4
  • 26S Proteasome Regulatory Subunit RPN1 4
  • 26S Proteasome Regulatory Subunit S2 4
  • 26S Proteasome Subunit P97 4
  • TNFR-Associated Protein 2 3
  • 55.11 Protein 3
  • RPN1 3
  • P97 3
  • S2 3

External Ids for PSMD2 Gene

Previous GeneCards Identifiers for PSMD2 Gene

  • GC03P180586
  • GC03P185010
  • GC03P185418
  • GC03P185337
  • GC03P185500
  • GC03P184016
  • GC03P181423

Summaries for PSMD2 Gene

Entrez Gene Summary for PSMD2 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for PSMD2 Gene

PSMD2 (Proteasome 26S Subunit, Non-ATPase 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include binding and enzyme regulator activity.

UniProtKB/Swiss-Prot for PSMD2 Gene

  • Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

  • Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.

Gene Wiki entry for PSMD2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD2 Gene

Genomics for PSMD2 Gene

Regulatory Elements for PSMD2 Gene

Promoters for PSMD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSMD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSMD2 Gene

Chromosome:
3
Start:
184,298,709 bp from pter
End:
184,309,054 bp from pter
Size:
10,346 bases
Orientation:
Plus strand

Genomic View for PSMD2 Gene

Genes around PSMD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD2 Gene

Proteins for PSMD2 Gene

  • Protein details for PSMD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13200-PSMD2_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 2
    Protein Accession:
    Q13200
    Secondary Accessions:
    • B4DX07
    • B4DXY1
    • E7EW34
    • E9PCS3
    • Q12932
    • Q15321
    • Q53XQ4
    • Q96I12

    Protein attributes for PSMD2 Gene

    Size:
    908 amino acids
    Molecular mass:
    100200 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA87705.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PSMD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD2 Gene

Proteomics data for PSMD2 Gene at MOPED

Post-translational modifications for PSMD2 Gene

  • Ubiquitination at Lys 31, Lys 66, Lys 105, Lys 141, Lys 178, Lys 286, Lys 292, Lys 350, Lys 397, Lys 441, Lys 754, Lys 773, Lys 858, Lys 860, and Lys 902
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSMD2 (PSMD2)
  • Cloud-Clone Corp. Antibodies for PSMD2

No data available for DME Specific Peptides for PSMD2 Gene

Domains & Families for PSMD2 Gene

Gene Families for PSMD2 Gene

Protein Domains for PSMD2 Gene

Suggested Antigen Peptide Sequences for PSMD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q13200

UniProtKB/Swiss-Prot:

PSMD2_HUMAN :
  • Belongs to the proteasome subunit S2 family.
  • Contains 7 PC repeats.
Family:
  • Belongs to the proteasome subunit S2 family.
Similarity:
  • Contains 7 PC repeats.
genes like me logo Genes that share domains with PSMD2: view

Function for PSMD2 Gene

Molecular function for PSMD2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
UniProtKB/Swiss-Prot Function:
Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.

Gene Ontology (GO) - Molecular Function for PSMD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 contributes_to endopeptidase activity IBA --
genes like me logo Genes that share ontologies with PSMD2: view
genes like me logo Genes that share phenotypes with PSMD2: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD2 Gene

Localization for PSMD2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMD2 Gene COMPARTMENTS Subcellular localization image for PSMD2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PSMD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008540 proteasome regulatory particle, base subcomplex IBA --
GO:0034515 proteasome storage granule IBA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with PSMD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD2 Gene

Pathways & Interactions for PSMD2 Gene

SuperPathways for PSMD2 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin-3, 5 and GM-CSF signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.48
5 Transport to the Golgi and subsequent modification
genes like me logo Genes that share pathways with PSMD2: view

Gene Ontology (GO) - Biological Process for PSMD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSMD2: view

No data available for SIGNOR curated interactions for PSMD2 Gene

Drugs & Compounds for PSMD2 Gene

(5) Drugs for PSMD2 Gene - From: DGIdb, FDA Approved Drugs, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other, Target Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 769
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
Velcade Approved May 2003 Pharma 0
MLN-9708 Pharma 0
OPROZOMIB Pharma 0
genes like me logo Genes that share compounds with PSMD2: view

Transcripts for PSMD2 Gene

Unigene Clusters for PSMD2 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^
SP1:
SP2: - - - - -
SP3:
SP4:
SP5:
SP6: - - - - - -
SP7:
SP8:
SP9: - - - - - - - - -
SP10: - - - - -
SP11:
SP12: - - -
SP13: - - - -
SP14: -
SP15: -
SP16:
SP17:

ExUns: 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for PSMD2 Gene

GeneLoc Exon Structure for
PSMD2
ECgene alternative splicing isoforms for
PSMD2

Expression for PSMD2 Gene

mRNA expression in normal human tissues for PSMD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSMD2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.5).

Protein differential expression in normal tissues from HIPED for PSMD2 Gene

This gene is overexpressed in Lymph node (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMD2 Gene



SOURCE GeneReport for Unigene cluster for PSMD2 Gene Hs.518464

mRNA Expression by UniProt/SwissProt for PSMD2 Gene

Q13200-PSMD2_HUMAN
Tissue specificity: Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.
genes like me logo Genes that share expression patterns with PSMD2: view

Protein tissue co-expression partners for PSMD2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PSMD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMD2 36
  • 100 (a)
OneToOne
PSMD2 35
  • 99.67 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia PSMD2 36
  • 99 (a)
OneToOne
PSMD2 35
  • 92.95 (n)
  • 99.23 (a)
dog
(Canis familiaris)
Mammalia PSMD2 35
  • 92.66 (n)
  • 99.23 (a)
PSMD2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm5422 36
  • 92 (a)
OneToMany
Psmd2 36
  • 99 (a)
OneToMany
Psmd2 16
Psmd2 35
  • 90.86 (n)
  • 98.68 (a)
oppossum
(Monodelphis domestica)
Mammalia PSMD2 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMD2 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmd2 35
  • 90.05 (n)
  • 98.57 (a)
chicken
(Gallus gallus)
Aves PSMD2 35
  • 81.3 (n)
  • 94.86 (a)
PSMD2 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMD2 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.26549 35
tropical clawed frog
(Silurana tropicalis)
Amphibia psmd2 35
  • 78.37 (n)
  • 92.08 (a)
Str.8194 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1127 35
zebrafish
(Danio rerio)
Actinopterygii psmd2 36
  • 95 (a)
OneToMany
PSMD2 (1 of 2) 36
  • 68 (a)
OneToMany
psmd2 35
  • 78.09 (n)
  • 91.57 (a)
zgc65921 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002481 35
  • 65 (n)
  • 70.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rpn1 35
  • 63.4 (n)
  • 62.81 (a)
Rpn1 37
  • 62 (a)
Rpn1 36
  • 61 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpn-1 35
  • 57.91 (n)
  • 57.09 (a)
rpn-1 36
  • 50 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR072C 35
  • 53.16 (n)
  • 47.41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN1 36
  • 40 (a)
OneToOne
RPN1 38
RPN1 35
  • 51.62 (n)
  • 48.02 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E11507g 35
  • 51.29 (n)
  • 46.95 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6563 35
soybean
(Glycine max)
eudicotyledons Gma.1623 35
thale cress
(Arabidopsis thaliana)
eudicotyledons RPN1A 35
  • 56.11 (n)
  • 53 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.1785 35
corn
(Zea mays)
Liliopsida Zm.5526 35
rice
(Oryza sativa)
Liliopsida Os.12327 35
Os09g0326800 35
  • 57.41 (n)
  • 54.72 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.20762 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07721 35
  • 55.46 (n)
  • 51.94 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mts4 35
  • 53.65 (n)
  • 50.24 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4602 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
OneToOne
Species with no ortholog for PSMD2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMD2 Gene

ENSEMBL:
Gene Tree for PSMD2 (if available)
TreeFam:
Gene Tree for PSMD2 (if available)

Paralogs for PSMD2 Gene

(1) SIMAP similar genes for PSMD2 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for PSMD2 Gene

genes like me logo Genes that share paralogs with PSMD2: view

No data available for Paralogs for PSMD2 Gene

Variants for PSMD2 Gene

Sequence variations from dbSNP and Humsavar for PSMD2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs11545172 - 184,301,893(+) ATGAC(A/G)CAGAG reference, missense
rs11545169 - 184,302,754(+) GAGGA(G/T)TATGA reference, missense
rs17856236 - 184,307,492(+) CCTAT(A/T)ACTCC reference, missense
rs1802799 -- 184,308,768(+) CGCAT(A/C)CAACC reference, missense
rs2272474 -- 184,299,204(-) AGACC(A/G)MCTCG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PSMD2 Gene

Variant ID Type Subtype PubMed ID
nsv829812 CNV Loss 17160897
nsv878057 CNV Loss 21882294
nsv878060 CNV Loss 21882294
nsv829813 CNV Loss 17160897
nsv878063 CNV Gain 21882294
esv2422400 CNV Duplication 17116639

Variation tolerance for PSMD2 Gene

Residual Variation Intolerance Score: 11.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.98; 68.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMD2 Gene

HapMap Linkage Disequilibrium report
PSMD2
Human Gene Mutation Database (HGMD)
PSMD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD2 Gene

Disorders for PSMD2 Gene

Relevant External Links for PSMD2

Genetic Association Database (GAD)
PSMD2
Human Genome Epidemiology (HuGE) Navigator
PSMD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMD2

No disorders were found for PSMD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMD2 Gene

Publications for PSMD2 Gene

  1. cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis- factor-receptor-associated protein-2/55.11. (PMID: 8774743) Tsurumi C. … Tanaka K. (Eur. J. Biochem. 1996) 2 3 4 23 67
  2. Two-hybrid cloning of a gene encoding TNF receptor-associated protein 2, a protein that interacts with the intracellular domain of the type 1 TNF receptor: identity with subunit 2 of the 26S protease. (PMID: 9126987) Dunbar J.D. … Donner D.B. (J. Immunol. 1997) 3 23
  3. Degradation of gap junction connexins is regulated by the interaction with Cx43-interacting protein of 75 kDa (CIP75). (PMID: 25583071) Kopanic J.L. … Su V.F. (Biochem. J. 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for PSMD2 Gene

Sources for PSMD2 Gene

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