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Aliases for PSMD14 Gene

Aliases for PSMD14 Gene

  • Proteasome 26S Subunit, Non-ATPase 14 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 14 2 3
  • 26S Proteasome-Associated PAD1 Homolog 1 3 4
  • POH1 3 4
  • Testis Tissue Sperm-Binding Protein Li 69n 3
  • 26S Proteasome Regulatory Subunit Rpn11 3
  • 26S Proteasome Regulatory Subunit RPN11 4
  • EC 3.1.2.15 63
  • EC 3.4.19.- 4
  • RPN11 3
  • PAD1 3

External Ids for PSMD14 Gene

Previous GeneCards Identifiers for PSMD14 Gene

  • GC02P160692
  • GC02P162128
  • GC02P162367
  • GC02P161990
  • GC02P161872
  • GC02P162164
  • GC02P154049

Summaries for PSMD14 Gene

Entrez Gene Summary for PSMD14 Gene

  • This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012]

GeneCards Summary for PSMD14 Gene

PSMD14 (Proteasome 26S Subunit, Non-ATPase 14) is a Protein Coding gene. Among its related pathways are Epstein-Barr virus infection and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include metallopeptidase activity and proteasome binding.

UniProtKB/Swiss-Prot for PSMD14 Gene

  • Metalloprotease component of the 26S proteasome that specifically cleaves Lys-63-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving Lys-63-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.

Gene Wiki entry for PSMD14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD14 Gene

Genomics for PSMD14 Gene

Regulatory Elements for PSMD14 Gene

Enhancers for PSMD14 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSMD14 on UCSC Golden Path with GeneCards custom track

Promoters for PSMD14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSMD14 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSMD14 Gene

Chromosome:
2
Start:
161,308,038 bp from pter
End:
161,411,717 bp from pter
Size:
103,680 bases
Orientation:
Plus strand

Genomic View for PSMD14 Gene

Genes around PSMD14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD14 Gene

Proteins for PSMD14 Gene

  • Protein details for PSMD14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00487-PSDE_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 14
    Protein Accession:
    O00487
    Secondary Accessions:
    • B3KNW2
    • O00176

    Protein attributes for PSMD14 Gene

    Size:
    310 amino acids
    Molecular mass:
    34577 Da
    Quaternary structure:
    • Component of the lid subcomplex of the 19S proteasome regulatory particle complex (also named PA700 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. Interacts with TXNL1.

neXtProt entry for PSMD14 Gene

Proteomics data for PSMD14 Gene at MOPED

Post-translational modifications for PSMD14 Gene

  • Ubiquitination at Lys 40, Lys 186, Lys 253, and Lys 257
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMD14 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSMD14 (PSMD14)
  • Santa Cruz Biotechnology (SCBT) Antibodies for PSMD14

Domains & Families for PSMD14 Gene

Gene Families for PSMD14 Gene

Protein Domains for PSMD14 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PSMD14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00487

UniProtKB/Swiss-Prot:

PSDE_HUMAN :
  • Contains 1 MPN (JAB/Mov34) domain.
  • Belongs to the peptidase M67A family. PSMD14 subfamily.
Domain:
  • Contains 1 MPN (JAB/Mov34) domain.
Family:
  • Belongs to the peptidase M67A family. PSMD14 subfamily.
genes like me logo Genes that share domains with PSMD14: view

Function for PSMD14 Gene

Molecular function for PSMD14 Gene

UniProtKB/Swiss-Prot Function:
Metalloprotease component of the 26S proteasome that specifically cleaves Lys-63-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving Lys-63-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.

Enzyme Numbers (IUBMB) for PSMD14 Gene

genes like me logo Genes that share phenotypes with PSMD14: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PSMD14

CRISPR Products

miRNA for PSMD14 Gene

miRTarBase miRNAs that target PSMD14

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD14 Gene

Localization for PSMD14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMD14 Gene COMPARTMENTS Subcellular localization image for PSMD14 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PSMD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PSMD14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD14 Gene

Pathways & Interactions for PSMD14 Gene

SuperPathways for PSMD14 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin-3, 5 and GM-CSF signaling
3 Infectious disease
.48
4 Immune System
5 Cell Cycle, Mitotic
.61
genes like me logo Genes that share pathways with PSMD14: view

Gene Ontology (GO) - Biological Process for PSMD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSMD14: view

No data available for SIGNOR curated interactions for PSMD14 Gene

Drugs & Compounds for PSMD14 Gene

(2) Drugs for PSMD14 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 776
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMD14: view

Transcripts for PSMD14 Gene

Unigene Clusters for PSMD14 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD14 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - - -
SP2: -
SP3: -
SP4: -
SP5:

Relevant External Links for PSMD14 Gene

GeneLoc Exon Structure for
PSMD14
ECgene alternative splicing isoforms for
PSMD14

Expression for PSMD14 Gene

mRNA expression in normal human tissues for PSMD14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMD14 Gene

This gene is overexpressed in Lymph node (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMD14 Gene



SOURCE GeneReport for Unigene cluster for PSMD14 Gene Hs.740477

mRNA Expression by UniProt/SwissProt for PSMD14 Gene

O00487-PSDE_HUMAN
Tissue specificity: Widely expressed. Highest levels in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with PSMD14: view

Protein tissue co-expression partners for PSMD14 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PSMD14 Gene

Orthologs for PSMD14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMD14 36
  • 100 (a)
OneToOne
PSMD14 35
  • 97.2 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia PSMD14 36
  • 99 (a)
OneToOne
PSMD14 35
  • 97.2 (n)
  • 98.7 (a)
oppossum
(Monodelphis domestica)
Mammalia PSMD14 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmd14 36
  • 100 (a)
OneToOne
Psmd14 16
Psmd14 35
  • 94.84 (n)
  • 100 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia PSMD14 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSMD14 36
  • 100 (a)
OneToOne
PSMD14 35
  • 100 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Psmd14 35
  • 93.87 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves PSMD14 36
  • 99 (a)
OneToOne
PSMD14 35
  • 90.54 (n)
  • 99.35 (a)
lizard
(Anolis carolinensis)
Reptilia PSMD14 36
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia psmd14-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2132 35
psmd14 35
  • 84.19 (n)
  • 99.03 (a)
zebrafish
(Danio rerio)
Actinopterygii psmd14 36
  • 98 (a)
OneToOne
wufb23b04 35
psmd14 35
  • 80.58 (n)
  • 98.38 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8283 35
fruit fly
(Drosophila melanogaster)
Insecta Rpn11 36
  • 89 (a)
OneToOne
Rpn11 35
  • 70.45 (n)
  • 89.69 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008617 35
  • 71.48 (n)
  • 89.35 (a)
worm
(Caenorhabditis elegans)
Secernentea rpn-11 36
  • 75 (a)
OneToOne
rpn-11 35
  • 66.67 (n)
  • 76.9 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN11 36
  • 66 (a)
OneToOne
RPN11 35
  • 60.69 (n)
  • 67.59 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E14147g 35
  • 63.46 (n)
  • 67.01 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR006W 35
  • 61.4 (n)
  • 65.98 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5065 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G23540 35
  • 70.7 (n)
  • 82.35 (a)
corn
(Zea mays)
Liliopsida Zm.4184 35
wheat
(Triticum aestivum)
Liliopsida Ta.27539 35
rice
(Oryza sativa)
Liliopsida Os01g0267200 35
  • 68.74 (n)
  • 82.07 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2961 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpn11 35
  • 65.86 (n)
  • 70.59 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00823 35
  • 61.57 (n)
  • 70.46 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2798 35
Species with no ortholog for PSMD14:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMD14 Gene

ENSEMBL:
Gene Tree for PSMD14 (if available)
TreeFam:
Gene Tree for PSMD14 (if available)

Paralogs for PSMD14 Gene

(1) SIMAP similar genes for PSMD14 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PSMD14 Gene

genes like me logo Genes that share paralogs with PSMD14: view

No data available for Paralogs for PSMD14 Gene

Variants for PSMD14 Gene

Sequence variations from dbSNP and Humsavar for PSMD14 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1559496 -- 161,358,583(+) GACCA(C/G)TCCTA intron-variant
rs1862953 -- 161,350,294(+) AATAC(A/T)GCCTG intron-variant
rs1863177 -- 161,401,288(+) TTCAG(A/T)CAACA intron-variant
rs1882366 -- 161,406,627(-) AATCA(A/T)ATGCC intron-variant
rs1921674 -- 161,391,261(+) AAATT(C/T)GAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMD14 Gene

Variant ID Type Subtype PubMed ID
nsv459934 CNV Loss 19166990
nsv437568 CNV Loss 16327808
nsv818094 CNV Loss 17921354

Variation tolerance for PSMD14 Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMD14 Gene

HapMap Linkage Disequilibrium report
PSMD14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD14 Gene

Disorders for PSMD14 Gene

Relevant External Links for PSMD14

Genetic Association Database (GAD)
PSMD14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMD14

No disorders were found for PSMD14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMD14 Gene

Publications for PSMD14 Gene

  1. Resistance to diverse drugs and ultraviolet light conferred by overexpression of a novel human 26 S proteasome subunit. (PMID: 9374539) Spataro V. … Norbury C. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. Relationship between expression of Pad1 homologue and multidrug resistance of idiopathic nephrotic syndrome. (PMID: 19419512) Ma Z. … Li C. (Pediatr Int 2009) 3 23
  3. The 19 S proteasomal subunit POH1 contributes to the regulation of c-Jun ubiquitination, stability, and subcellular localization. (PMID: 16569633) Nabhan J.F. … Ribeiro P. (J. Biol. Chem. 2006) 3 23
  4. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for PSMD14 Gene

Sources for PSMD14 Gene

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