Aliases for PSMD14 Gene
External Ids for PSMD14 Gene
Previous GeneCards Identifiers for PSMD14 Gene
This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012]
GeneCards Summary for PSMD14 Gene
PSMD14 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 14) is a Protein Coding gene. Diseases associated with PSMD14 include hereditary renal cell carcinoma. Among its related pathways are Signaling by GPCR and Downstream Signaling Events Of B Cell Receptor (BCR). GO annotations related to this gene include ubiquitin thiolesterase activity and proteasome binding.
UniProtKB/Swiss-Prot for PSMD14 Gene
Metalloprotease component of the 26S proteasome that specifically cleaves Lys-63-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving Lys-63-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.