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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PSMD14 Gene

protein-coding   GIFtS: 63
GCID: GC02P162164

proteasome (prosome, macropain) 26S subunit, non-ATPase,...
 Explore 5 diseases affiliated with
PSMD14 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PSMD14    

Aliases
for PSMD14 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 141 2     Pad11
POH11 2 3 5     26S Proteasome Non-ATPase Regulatory Subunit 142
26S Proteasome Regulatory Subunit RPN112 3     RPN112
26S Proteasome-Associated PAD1 Homolog 12 3     EC 3.4.19.-3
PAD12 5     EC 3.1.2.158
Rpn111     

External Ids:    HGNC: 168891   Entrez Gene: 102132   Ensembl: ENSG000001152337   OMIM: 6071735   UniProtKB: O004873   

Export aliases for PSMD14 gene to outside databases

Previous GC identifers: GC02P160692 GC02P162128 GC02P162367 GC02P161990 GC02P161872 GC02P154049


Summaries
for PSMD14 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PSMD14:
This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes
the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap
complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on
the long arm of chromosome 2. (provided by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: PSDE_HUMAN, O00487
Function: Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin
chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in
response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving
'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1
accumulation. Also involved in homologous recombination repair by promoting RAD51 loading

Gene Wiki entry for PSMD14


Genomic Views
for PSMD14 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PSMD14 gene promoter:
         c-Fos   AP-1   ATF-2   FosB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PSMD14 promoter sequence
   Search SABiosciences Chromatin IP Primers for PSMD14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSMD14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.2   Ensembl cytogenetic band:  2q24.2   HGNC cytogenetic band: 2q14.3

PSMD14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMD14 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P162164:  view genomic region     (about GC identifiers)

Start:
 162,164,549 bp from pter      End:
 162,268,228 bp from pter
Size:
 103,680 bases      Orientation:
 plus strand

Proteins
for PSMD14 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PSDE_HUMAN, O00487 (See protein sequence)
Recommended Name: 26S proteasome non-ATPase regulatory subunit 14  
Size: 310 amino acids; 34577 Da
Subunit: Component of the lid subcomplex of the 19S proteasome regulatory particle complex (also named PA700 complex).
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. Interacts with TXNL1
Secondary accessions: B3KNW2 O00176

Explore the universe of human proteins at neXtProt for PSMD14: NX_O00487

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00487

    • 4/7 DME Specific Peptides for PSMD14 (O00487) (see all 7)
     NTQQSFE  LAIKNVGK  INYRKNELE  ISSLALLKML 

    PSMD14 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005796.1  
    ENSEMBL proteins: 
     ENSP00000386541   ENSP00000399311  
    Reactome Protein details: O00487
    Human Recombinant Protein Products: 
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    Novus Biologicals PSMD14 Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PSMD14

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex TAS19214193
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0008541proteasome regulatory particle, lid subcomplex IMP--
    GO:0022624proteasome accessory complex ISS--


    PSMD14 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PSMD14

    Protein Domains /
    Families
    for PSMD14 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PSMD14 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000555 JAB1_Mov34_MPN_PAD1
     IPR024969 Rpn11/EIF3F_C

    Graphical View of Domain Structure for InterPro Entry O00487

    ProtoNet protein and cluster: O00487

    1 Blocks protein family: IPB000555 Mov34 family

    UniProtKB/Swiss-Prot: PSDE_HUMAN, O00487
    Similarity: Belongs to the peptidase M67A family. PSMD14 subfamily
    Similarity: Contains 1 MPN (JAB/Mov34) domain


    Function
    for PSMD14 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PSDE_HUMAN, O00487
    Function: Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin
    chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in
    response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving
    'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1
    accumulation. Also involved in homologous recombination repair by promoting RAD51 loading

    Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.-1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSMD14
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate PSMD14 (see all 9):
    hsa-miR-3671 hsa-miR-92a hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-3171 hsa-miR-363 hsa-miR-29a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: PSMD14
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity TAS19214193
    GO:0008237metallopeptidase activity TAS19214193
    GO:0046872metal ion binding IEA--
    GO:0061133endopeptidase activator activity IMP18162577
    GO:0070628proteasome binding IDA18162577


    PSMD14 for ontologies           About GeneDecksing


    8 GenomeRNAi human phenotypes for PSMD14:
     Cell cycle / mitosis defect  Decreased cell number  Decreased homologous recombina  Decreased influenza A H1N1 (A/ 
     Decreased influenza A/WSN/33 r  Decreased viability of wild-ty  G0/1 arrest  Increased cell death in breast 


    Pathways & Interactions
    for PSMD14 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitinated Orc1 is degraded by the proteasome
    8/75 pathways (see all 75)
    		Ubiquitinated Orc1 is degraded by the proteasome1.00
    		Assembly of the pre-replicative complex0.77
    		Proteasomal cleavage of substrate0.98
    		Degradation of ubiquitinated p27/p21 by the 26S proteasome0.75
    		Proteasome mediated degradation of PAK-2p340.98
    		SCF(Skp2)-mediated degradation of p27/p210.75
    		Proteasomal cleavage of substrate0.98
    		APC/C:Cdh1-mediated degradation of Skp20.74
    2M Phase
    		M Phase1.00
    		Mitotic Anaphase0.85
    		Mitotic M-M/G1 phases0.88
    		Separation of Sister Chromatids0.80
    		Mitotic Metaphase and Anaphase0.85
    3HIV Infection
    		HIV Infection1.00
    		Transcription_Ligand-Dependent Transcription of Retinoid-Target genes0.28
    		Host Interactions of HIV factors0.64
    		Transcription Ligand-Dependent Transcription of Retinoid-Target genes0.28
    4Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    		Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway1.00
    		Parkin-Ubiquitin Proteasomal System pathway0.93
    		Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    5Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Class I MHC mediated antigen processing & presentation0.83

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for PSMD14
        Immune response Antigen presentation by MHC class I
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PSMD14
        Remodeling of Adherens Junctions
    RAR-Gamma-RXR-Alpha Degradation

    1 Cell Signaling Technology (CST) Pathway for PSMD14
        Protein Stability

    3 GeneGo (Thomson Reuters) Pathways for PSMD14
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Antigen presentation by MHC class I

    1 BioSystems Pathway for PSMD14 
        Parkin-Ubiquitin Proteasomal System pathway

    5/98        Reactome Pathways for PSMD14 (see all 98)
        Ubiquitinated geminin is degraded by the proteasome
    Proteolytic degradation of ubiquitinated-Cdc25A
    Orc1 removal from chromatin
    CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway


    1         Kegg Pathway  (Kegg details for PSMD14):
        Proteasome


    PSMD14 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PSMD14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/598 Interacting proteins for PSMD14 (O004872, 3 ENSP000003865414) via UniProtKB, MINT, STRING, and/or I2D (see all 598)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/29 biological process terms (GO ID links to tree view) (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000084S phase of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000216M/G1 transition of mitotic cell cycle TAS--


    PSMD14 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PSMD14 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PSMD14
    Search CenterWatch for drugs/clinical trials and news about PSMD14 / PSDE 

    Transcripts
    for PSMD14 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PSMD14 gene: 
    NM_005805.5  

    Unigene Cluster for PSMD14:

    Proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
    Hs.740477  [show with all ESTs]
    Unigene Representative Sequence: AB209220
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409682(uc002ubu.2) ENST00000478123 ENST00000437630 ENST00000477232
    ENST00000492908

    miRNA
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    hsa-miR-3671 hsa-miR-92a hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-3171 hsa-miR-363 hsa-miR-29a*
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    Clone
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    Additional cDNA sequence: 

    AB209220.1 AK055128.1 AK091095.1 BC009524.1 BC066336.1 U86782.1 

    11 DOTS entries:

    DT.454530  DT.95307891  DT.422466  DT.40238609  DT.99939165  DT.100815485  DT.100815487  DT.101985697 
    DT.91761290  DT.95149152  DT.91761281 

    24/330 AceView cDNA sequences (see all 330):

    CR617325 BU729969 BE886981 BU178023 CA416413 CB219174 BM853674 AA306073 
    BG435138 AI492110 BM712859 BQ772201 BQ691109 CR606475 CB145914 AW102894 
    BM550388 CD513062 U86782 BU621390 BM978668 BX506781 CA431624 BQ011444 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PSMD14    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:                    -                 -                             -                       -                     
    SP2:                                      -                                                                           
    SP3:                                                                                            -                     
    SP4:                    -                                                                                             
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for PSMD14

    Expression
    for PSMD14 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PSMD14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATACATCAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PSMD14 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PSMD14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PSMD14

    SOURCE GeneReport for Unigene cluster: Hs.740477

    UniProtKB/Swiss-Prot: PSDE_HUMAN, O00487
    Tissue specificity: Widely expressed. Highest levels in heart and skeletal muscle

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    In Situ
    Assay Products:     
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    Orthologs
    for PSMD14 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PSMD14 gene from 9/39 species (see all 39)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PSMD141 proteasome (prosome, macropain) 26S subunit, non-ATPase, more 90.54(n)
    99.35(a)    		   424189  NM_001031256.2  NP_001026427.2 
    lizard
    (Anolis carolinensis)    		 Reptilia PSMD146
    		 --
    		 96(a)
    		 1 ↔ 1
    		 GL343359.1(1113478-1148720)
    African clawed frog
    (Xenopus laevis)    		 Amphibia psmd14-prov2 26S proteasome-associated pad1 homolog 84.73(n)    BC045094.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb23b042 Transcribed sequence with strong similarity to protein more 81.24(n)    CK354852.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Rpn111 CG18174-PA 70.02(n)
    88.96(a)    		   33738  NM_135061.3  NP_608905.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea rpn-111 Protein RPN-11 66.12(n)
    76.14(a)    		   173744  NM_062311.4  NP_494712.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes RPN111 Rpn11p 61.29(n)
    68.42(a)    		   850554   NP_116659.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G235401 26S proteasome non-ATPase regulatory subunit 14 69.81(n)
    80.19(a)    		   832420  NM_122261.2  NP_197745.1 
    rice
    (Oryza sativa)    		 Liliopsida AB037152.12   -- 74.69(n)    AB037152.1 


    ENSEMBL Gene Tree for PSMD14 (if available)
    TreeFam Gene Tree for PSMD14 (if available) 

    Paralogs
    for PSMD14 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PSMD14 gene
    EIF3H2  
    1 SIMAP similar gene for PSMD14 using alignment to 4 protein entries:     PSDE_HUMAN (see all proteins):
    COPS5

    PSMD14 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PSMD14
    PGOHUM00000259800


    Genomic Variants
    for PSMD14 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1301 NCBI SNPs in PSMD14 are shown (see all 1301)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1487104501,2
    		--162162804(+) AAAGTC/TTGCAT 1 -- us2k10--------
    rs1903228461,2
    		--162162839(+) GTTTCC/TGCTCA 1 -- us2k10--------
    rs1423598411,2
    		--162162995(+) GTACCA/GAAGTA 1 -- us2k10--------
    rs1824878891,2
    		--162163023(+) AAACCA/GCAATT 1 -- us2k10--------
    rs1512706111,2
    		--162163250(+) TACTTC/TAGTAT 1 -- us2k10--------
    rs1836768941,2
    		--162163398(+) CCAGTA/GAGGTG 1 -- us2k10--------
    rs1393735161,2
    		--162163633(+) GCCCAC/GATGGC 1 -- us2k10--------
    rs1883393501,2
    		--162163663(+) CGTGAC/TAAAGC 1 -- us2k10--------
    rs1455526981,2
    		--162163679(+) CCTAAC/TTCAAA 1 -- us2k10--------
    rs739711821,2
    		C,--162163807(+) TGTTAT/CGGAGA 1 -- us2k12Minor allele frequency- C:0.12WA 120

    HapMap Linkage Disequilibrium report for PSMD14 (162164549 - 162268228 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PSMD14
         2 CNVs: 9968 1358

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    Disorders / Diseases
    for PSMD14 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PSMD14 for disorders           About GeneDecksing

    OMIM gene information: 607173    OMIM disorders: --

    5 diseases for PSMD14:    About MalaCards
    hereditary renal cell carcinoma    renal cell carcinoma    nephrotic syndrome    malaria
    carcinoma

    1 disease from the University of Copenhagen DISEASES database for PSMD14:
    Hereditary renal cell carcinoma

    Export disorders for PSMD14 gene to outside databases

    Publications
    for PSMD14 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PSMD14 gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with PSMD14)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Resistance to diverse drugs and ultraviolet light conferred by overexpression of a novel human 26 S proteasome subunit. (PubMed id 9374539)1, 2, 3, 9 Spataro V....Norbury C. (1997)
    2. The proteasomal de-ubiquitinating enzyme POH1 promotes the double- strand DNA break response. (PubMed id 22909820)1, 2 Butler L.R.... Morris J.R. (2012)
    3. Thioredoxin Txnl1/TRP32 Is a Redox-active Cofactor of the 26 S Proteasome. (PubMed id 19349277)1, 2 Andersen K.M....Hartmann-Petersen R. (2009)
    4. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC- associated Brcc36 and proteasomal Poh1. (PubMed id 19214193)1, 2 Cooper E.M....Cohen R.E. (2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The 19 S proteasomal subunit POH1 contributes to the regulation of c-Jun ubiquitination, stability, and subcellular localization. (PubMed id 16569633)1, 9 Nabhan J.F. and Ribeiro P. (2006)
    8. Relationship between expression of Pad1 homologue and multidrug resistance of idiopathic nephrotic syndrome. (PubMed id 19419512)1, 9 Ma Z....Li C. (2009)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    External Searches for PSMD14 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PSMD14 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10213 HGNC: 16889 AceView: PSMD14 Ensembl:ENSG00000115233 euGenes: HUgn10213
    ECgene: PSMD14 Kegg: 10213 H-InvDB: PSMD14

    Other Databases showing PSMD14 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PSMD14 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PSMD14 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PSMD14 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PSMD14 gene:
    Search GeneIP for patents involving PSMD14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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