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Aliases for PSMD14 Gene

Aliases for PSMD14 Gene

  • Proteasome 26S Subunit, Non-ATPase 14 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 14 2 3
  • 26S Proteasome-Associated PAD1 Homolog 1 3 4
  • POH1 3 4
  • 26S Proteasome Non-ATPase Regulatory Subunit 14 3
  • Testis Tissue Sperm-Binding Protein Li 69n 3
  • 26S Proteasome Regulatory Subunit Rpn11 3
  • 26S Proteasome Regulatory Subunit RPN11 4
  • EC 3.1.2.15 56
  • EC 3.4.19.- 4
  • RPN11 3
  • PAD1 3

External Ids for PSMD14 Gene

Previous GeneCards Identifiers for PSMD14 Gene

  • GC02P160692
  • GC02P162128
  • GC02P162367
  • GC02P161990
  • GC02P161872
  • GC02P162164
  • GC02P154049

Summaries for PSMD14 Gene

Entrez Gene Summary for PSMD14 Gene

  • This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012]

GeneCards Summary for PSMD14 Gene

PSMD14 (Proteasome 26S Subunit, Non-ATPase 14) is a Protein Coding gene. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include metallopeptidase activity and proteasome binding.

UniProtKB/Swiss-Prot for PSMD14 Gene

  • Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves Lys-63-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving Lys-63-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.

Gene Wiki entry for PSMD14 Gene

Additional gene information for PSMD14 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD14 Gene

Genomics for PSMD14 Gene

GeneHancer (GH) Regulatory Elements for PSMD14 Gene

Promoters and enhancers for PSMD14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I161307 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.7 728 2.9 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 PSMD14 LOC101929512 LINC01806 TANK GC02M161340
GH02I161340 Promoter/Enhancer 1 FANTOM5 Ensembl 0.3 +33.1 33063 0.6 ZBTB33 CHAMP1 LOC100506055 GC02M161340 PSMD14
GH02I161371 Enhancer 0.6 UCNEbase 0.2 +64.1 64058 0.2 ZNF316 POLR2A MAFK LOC100506055 RNA5SP108 PSMD14
GH02I161360 Enhancer 0.6 ENCODE 0.2 +52.2 52227 0.2 SAP130 SP5 NR2F1 ZNF384 ZNF644 RARA RCOR2 FOS NR2F6 SMAD4 LOC100506055 RNA5SP108 PSMD14
GH02I161381 Enhancer 0.5 UCNEbase 0.2 +74.1 74146 0.7 ZNF395 LOC100506055 ENSG00000251621 ENSG00000224076 SLC4A10 RNA5SP108 PSMD14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PSMD14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSMD14 gene promoter:

Genomic Locations for PSMD14 Gene

Genomic Locations for PSMD14 Gene
chr2:161,308,038-161,411,717
(GRCh38/hg38)
Size:
103,680 bases
Orientation:
Plus strand
chr2:162,164,549-162,268,228
(GRCh37/hg19)

Genomic View for PSMD14 Gene

Genes around PSMD14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD14 Gene

Proteins for PSMD14 Gene

  • Protein details for PSMD14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00487-PSDE_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 14
    Protein Accession:
    O00487
    Secondary Accessions:
    • B3KNW2
    • O00176

    Protein attributes for PSMD14 Gene

    Size:
    310 amino acids
    Molecular mass:
    34577 Da
    Quaternary structure:
    • Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD4, a base containing 6 ATPases and few additional components (PubMed:27428775, PubMed:27342858). Within the complex, PSMD4 interacts with subunit PSMD7 through their respective MPN domain. Interacts with TXNL1 (PubMed:19349277).

    Three dimensional structures from OCA and Proteopedia for PSMD14 Gene

neXtProt entry for PSMD14 Gene

Selected DME Specific Peptides for PSMD14 Gene

O00487:
  • QALIHGLNRHYYSI
  • ISSLALLKML
  • RAVAVVVDPIQSVKGKVVIDAFR
  • INYRKNELE
  • NTQQSFE
  • GWYHSHPGFGCWLS
  • LAIKNVGK

Post-translational modifications for PSMD14 Gene

  • Ubiquitination at Lys40, Lys186, Lys253, and Lys257

Other Protein References for PSMD14 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSMD14 (PSMD14)
  • Abcam antibodies for PSMD14
  • Santa Cruz Biotechnology (SCBT) Antibodies for PSMD14

Domains & Families for PSMD14 Gene

Gene Families for PSMD14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PSMD14 Gene

Suggested Antigen Peptide Sequences for PSMD14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00487

UniProtKB/Swiss-Prot:

PSDE_HUMAN :
  • Belongs to the peptidase M67A family. PSMD14 subfamily.
Family:
  • Belongs to the peptidase M67A family. PSMD14 subfamily.
genes like me logo Genes that share domains with PSMD14: view

Function for PSMD14 Gene

Molecular function for PSMD14 Gene

UniProtKB/Swiss-Prot Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves Lys-63-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving Lys-63-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.

Enzyme Numbers (IUBMB) for PSMD14 Gene

Phenotypes From GWAS Catalog for PSMD14 Gene

Gene Ontology (GO) - Molecular Function for PSMD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19615732
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity TAS 19214193
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS 19214193
genes like me logo Genes that share ontologies with PSMD14: view
genes like me logo Genes that share phenotypes with PSMD14: view

Animal Model Products

CRISPR Products

miRNA for PSMD14 Gene

miRTarBase miRNAs that target PSMD14

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD14 Gene

Localization for PSMD14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMD14 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PSMD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS 19214193
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA,HDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMD14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD14 Gene

Pathways & Interactions for PSMD14 Gene

SuperPathways for PSMD14 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 HIV Life Cycle
.45
4 Class I MHC mediated antigen processing and presentation
5 Antigen processing-Cross presentation
genes like me logo Genes that share pathways with PSMD14: view

Gene Ontology (GO) - Biological Process for PSMD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000724 double-strand break repair via homologous recombination IMP 22909820
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
genes like me logo Genes that share ontologies with PSMD14: view

No data available for SIGNOR curated interactions for PSMD14 Gene

Drugs & Compounds for PSMD14 Gene

(2) Drugs for PSMD14 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 826
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMD14: view

Transcripts for PSMD14 Gene

Unigene Clusters for PSMD14 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD14 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - - -
SP2: -
SP3: -
SP4: -
SP5:

Relevant External Links for PSMD14 Gene

GeneLoc Exon Structure for
PSMD14
ECgene alternative splicing isoforms for
PSMD14

Expression for PSMD14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMD14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMD14 Gene

This gene is overexpressed in Lymph node (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMD14 Gene



Protein tissue co-expression partners for PSMD14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMD14 Gene:

PSMD14

SOURCE GeneReport for Unigene cluster for PSMD14 Gene:

Hs.740477

mRNA Expression by UniProt/SwissProt for PSMD14 Gene:

O00487-PSDE_HUMAN
Tissue specificity: Widely expressed. Highest levels in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for PSMD14 Gene

  • Nervous system(4.7)
  • Liver(4.4)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with PSMD14: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMD14 Gene

Orthologs for PSMD14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMD14 33 34
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMD14 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMD14 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSMD14 33 34
  • 97.2 (n)
dog
(Canis familiaris)
Mammalia PSMD14 33 34
  • 97.2 (n)
mouse
(Mus musculus)
Mammalia Psmd14 33 16 34
  • 94.84 (n)
rat
(Rattus norvegicus)
Mammalia Psmd14 33
  • 93.87 (n)
chicken
(Gallus gallus)
Aves PSMD14 33 34
  • 90.54 (n)
lizard
(Anolis carolinensis)
Reptilia PSMD14 34
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmd14 33
  • 84.19 (n)
Str.2132 33
African clawed frog
(Xenopus laevis)
Amphibia psmd14-prov 33
zebrafish
(Danio rerio)
Actinopterygii psmd14 33 34
  • 80.58 (n)
wufb23b04 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8283 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008617 33
  • 71.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rpn11 33 34
  • 70.45 (n)
worm
(Caenorhabditis elegans)
Secernentea rpn-11 33 34
  • 66.67 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E14147g 33
  • 63.46 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR006W 33
  • 61.4 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN11 33 34
  • 60.69 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G23540 33
  • 70.7 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5065 33
rice
(Oryza sativa)
Liliopsida Os01g0267200 33
  • 68.74 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.2961 33
wheat
(Triticum aestivum)
Liliopsida Ta.27539 33
corn
(Zea mays)
Liliopsida Zm.4184 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpn11 33
  • 65.86 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00823 33
  • 61.57 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2798 33
Species where no ortholog for PSMD14 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMD14 Gene

ENSEMBL:
Gene Tree for PSMD14 (if available)
TreeFam:
Gene Tree for PSMD14 (if available)

Paralogs for PSMD14 Gene

(1) SIMAP similar genes for PSMD14 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PSMD14 Gene

genes like me logo Genes that share paralogs with PSMD14: view

No data available for Paralogs for PSMD14 Gene

Variants for PSMD14 Gene

Sequence variations from dbSNP and Humsavar for PSMD14 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000013984 -- 161,394,983(+) G/A intron_variant
rs1000045235 -- 161,395,381(+) C/A intron_variant
rs1000060132 -- 161,366,295(+) T/A intron_variant
rs1000100714 -- 161,310,679(+) T/C intron_variant
rs1000113773 -- 161,359,091(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PSMD14 Gene

Variant ID Type Subtype PubMed ID
nsv437568 CNV loss 16327808
nsv459934 CNV loss 19166990
nsv583500 CNV loss 21841781
nsv818094 CNV loss 17921354
nsv963740 CNV duplication 23825009

Variation tolerance for PSMD14 Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMD14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMD14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD14 Gene

Disorders for PSMD14 Gene

Additional Disease Information for PSMD14

No disorders were found for PSMD14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMD14 Gene

Publications for PSMD14 Gene

  1. Resistance to diverse drugs and ultraviolet light conferred by overexpression of a novel human 26 S proteasome subunit. (PMID: 9374539) Spataro V … Norbury C (The Journal of biological chemistry 1997) 2 3 4 22 58
  2. The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response. (PMID: 22909820) Butler LR … Morris JR (The EMBO journal 2012) 3 4 58
  3. Thioredoxin Txnl1/TRP32 is a redox-active cofactor of the 26 S proteasome. (PMID: 19349277) Andersen KM … Hartmann-Petersen R (The Journal of biological chemistry 2009) 3 4 58
  4. Relationship between expression of Pad1 homologue and multidrug resistance of idiopathic nephrotic syndrome. (PMID: 19419512) Ma Z … Li C (Pediatrics international : official journal of the Japan Pediatric Society 2009) 3 22 58
  5. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1. (PMID: 19214193) Cooper EM … Cohen RE (The EMBO journal 2009) 3 4 58

Products for PSMD14 Gene

Sources for PSMD14 Gene

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