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Aliases for PSMD14 Gene

Aliases for PSMD14 Gene

  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 14 2 3
  • POH1 3 4 6
  • 26S Proteasome-Associated PAD1 Homolog 1 3 4
  • PAD1 3 6
  • 26S Proteasome Non-ATPase Regulatory Subunit 14 3
  • 26S Proteasome Regulatory Subunit Rpn11 3
  • 26S Proteasome Regulatory Subunit RPN11 4
  • EC 3.1.2.15 63
  • EC 3.4.19.- 4
  • RPN11 3

External Ids for PSMD14 Gene

Previous GeneCards Identifiers for PSMD14 Gene

  • GC02P160692
  • GC02P162128
  • GC02P162367
  • GC02P161990
  • GC02P161872
  • GC02P162164
  • GC02P154049

Summaries for PSMD14 Gene

Entrez Gene Summary for PSMD14 Gene

  • This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012]

GeneCards Summary for PSMD14 Gene

PSMD14 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 14) is a Protein Coding gene. Diseases associated with PSMD14 include hereditary renal cell carcinoma. Among its related pathways are Signaling by GPCR and Downstream Signaling Events Of B Cell Receptor (BCR). GO annotations related to this gene include ubiquitin thiolesterase activity and proteasome binding.

UniProtKB/Swiss-Prot for PSMD14 Gene

  • Metalloprotease component of the 26S proteasome that specifically cleaves Lys-63-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving Lys-63-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.

Gene Wiki entry for PSMD14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD14 Gene

Genomics for PSMD14 Gene

Regulatory Elements for PSMD14 Gene

Genomic Location for PSMD14 Gene

Start:
161,308,038 bp from pter
End:
161,411,717 bp from pter
Size:
103,680 bases
Orientation:
Plus strand

Genomic View for PSMD14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSMD14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD14 Gene

Proteins for PSMD14 Gene

  • Protein details for PSMD14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00487-PSDE_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 14
    Protein Accession:
    O00487
    Secondary Accessions:
    • B3KNW2
    • O00176

    Protein attributes for PSMD14 Gene

    Size:
    310 amino acids
    Molecular mass:
    34577 Da
    Quaternary structure:
    • Component of the lid subcomplex of the 19S proteasome regulatory particle complex (also named PA700 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. Interacts with TXNL1.

neXtProt entry for PSMD14 Gene

Proteomics data for PSMD14 Gene at MOPED

Post-translational modifications for PSMD14 Gene

  • Ubiquitination at Lys40, Lys186, Lys253, and Lys257
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMD14 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PSMD14 Gene

Gene Families for PSMD14 Gene

HGNC:
  • PSM :Proteasome (prosome, macropain) subunits

Protein Domains for PSMD14 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PSMD14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00487

UniProtKB/Swiss-Prot:

PSDE_HUMAN :
  • O00487
Domain:
  • Contains 1 MPN (JAB/Mov34) domain.
Family:
  • Belongs to the peptidase M67A family. PSMD14 subfamily.
genes like me logo Genes that share domains with PSMD14: view

Function for PSMD14 Gene

Molecular function for PSMD14 Gene

UniProtKB/Swiss-Prot Function: Metalloprotease component of the 26S proteasome that specifically cleaves Lys-63-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving Lys-63-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.

Enzyme Numbers (IUBMB) for PSMD14 Gene

Gene Ontology (GO) - Molecular Function for PSMD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004221 ubiquitin thiolesterase activity --
GO:0005515 protein binding IPI 19615732
GO:0008237 metallopeptidase activity TAS 19214193
GO:0046872 metal ion binding IEA --
GO:0061133 endopeptidase activator activity IMP 18162577
genes like me logo Genes that share ontologies with PSMD14: view
genes like me logo Genes that share phenotypes with PSMD14: view

miRNA for PSMD14 Gene

miRTarBase miRNAs that target PSMD14

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PSMD14 Gene

Localization for PSMD14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMD14 Gene COMPARTMENTS Subcellular localization image for PSMD14 gene
Compartment Confidence
cytosol 4
nucleus 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PSMD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS 19214193
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0008541 proteasome regulatory particle, lid subcomplex IMP 22909820
genes like me logo Genes that share ontologies with PSMD14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD14 Gene

Pathways for PSMD14 Gene

SuperPathways for PSMD14 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.38
2 Class I MHC mediated antigen processing and presentation
3 Cell Cycle, Mitotic
.62
4 Mitotic Metaphase and Anaphase
5 Downstream Signaling Events Of B Cell Receptor (BCR)
genes like me logo Genes that share pathways with PSMD14: view

Gene Ontology (GO) - Biological Process for PSMD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0000724 double-strand break repair via homologous recombination IMP 22909820
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with PSMD14: view

Transcripts for PSMD14 Gene

Unigene Clusters for PSMD14 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD14 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - - -
SP2: -
SP3: -
SP4: -
SP5:

Relevant External Links for PSMD14 Gene

GeneLoc Exon Structure for
PSMD14
ECgene alternative splicing isoforms for
PSMD14

Expression for PSMD14 Gene

mRNA expression in normal human tissues for PSMD14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMD14 Gene

SOURCE GeneReport for Unigene cluster for PSMD14 Gene Hs.740477

mRNA Expression by UniProt/SwissProt for PSMD14 Gene

O00487-PSDE_HUMAN
Tissue specificity: Widely expressed. Highest levels in heart and skeletal muscle.
genes like me logo Genes that share expressions with PSMD14: view

No data available for mRNA differential expression in normal tissues for PSMD14 Gene

Orthologs for PSMD14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMD14 35
  • 100 (n)
  • 100 (a)
PSMD14 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSMD14 35
  • 97.2 (n)
  • 100 (a)
PSMD14 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMD14 35
  • 97.2 (n)
  • 98.7 (a)
PSMD14 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmd14 35
  • 94.84 (n)
  • 100 (a)
Psmd14 16
Psmd14 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PSMD14 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMD14 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmd14 35
  • 93.87 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves PSMD14 35
  • 90.54 (n)
  • 99.35 (a)
PSMD14 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMD14 36
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia psmd14-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia psmd14 35
  • 84.19 (n)
  • 99.03 (a)
Str.2132 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8283 35
zebrafish
(Danio rerio)
Actinopterygii psmd14 35
  • 80.58 (n)
  • 98.38 (a)
psmd14 36
  • 98 (a)
OneToOne
wufb23b04 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008617 35
  • 71.48 (n)
  • 89.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rpn11 35
  • 70.45 (n)
  • 89.69 (a)
Rpn11 36
  • 89 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpn-11 35
  • 66.67 (n)
  • 76.9 (a)
rpn-11 36
  • 75 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR006W 35
  • 61.4 (n)
  • 65.98 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN11 35
  • 60.69 (n)
  • 67.59 (a)
RPN11 36
  • 66 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E14147g 35
  • 63.46 (n)
  • 67.01 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5065 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G23540 35
  • 70.7 (n)
  • 82.35 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2961 35
corn
(Zea mays)
Liliopsida Zm.4184 35
rice
(Oryza sativa)
Liliopsida Os01g0267200 35
  • 68.74 (n)
  • 82.07 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.27539 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00823 35
  • 61.57 (n)
  • 70.46 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpn11 35
  • 65.86 (n)
  • 70.59 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2798 35
Species with no ortholog for PSMD14:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMD14 Gene

ENSEMBL:
Gene Tree for PSMD14 (if available)
TreeFam:
Gene Tree for PSMD14 (if available)

Paralogs for PSMD14 Gene

Selected SIMAP similar genes for PSMD14 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PSMD14 Gene

genes like me logo Genes that share paralogs with PSMD14: view

No data available for Paralogs for PSMD14 Gene

Variants for PSMD14 Gene

Sequence variations from dbSNP and Humsavar for PSMD14 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs9713 -- 161,308,497(+) CAGAC(A/T)GAGCC utr-variant-5-prime
rs1064576 -- 161,411,597(+) CTAAA(A/G)TTATA utr-variant-3-prime
rs1110587 -- 161,407,766(+) TCACC(C/T)CCTTT intron-variant
rs1111416 -- 161,355,716(-) ATAAA(C/T)GAGTT intron-variant
rs1111417 -- 161,352,474(-) TTATT(C/T)TAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMD14 Gene

Variant ID Type Subtype PubMed ID
nsv459934 CNV Loss 19166990
nsv437568 CNV Loss 16327808
nsv818094 CNV Loss 17921354

Relevant External Links for PSMD14 Gene

HapMap Linkage Disequilibrium report
PSMD14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD14 Gene

Disorders for PSMD14 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PSMD14 Gene including...

Search for PSMD14 Gene in MalaCards »

(1) University of Copenhagen DISEASES for PSMD14 Gene

Relevant External Links for PSMD14

Genetic Association Database (GAD)
PSMD14
genes like me logo Genes that share disorders with PSMD14: view

No data available for UniProtKB/Swiss-Prot for PSMD14 Gene

Publications for PSMD14 Gene

  1. Resistance to diverse drugs and ultraviolet light conferred by overexpression of a novel human 26 S proteasome subunit. (PMID: 9374539) Spataro V. … Norbury C. (J. Biol. Chem. 1997) 2 3 4 23
  2. The 19 S proteasomal subunit POH1 contributes to the regulation of c-Jun ubiquitination, stability, and subcellular localization. (PMID: 16569633) Nabhan J.F. … Ribeiro P. (J. Biol. Chem. 2006) 3 23
  3. Relationship between expression of Pad1 homologue and multidrug resistance of idiopathic nephrotic syndrome. (PMID: 19419512) Ma Z. … Li C. (Pediatr Int 2009) 3 23
  4. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X. … Huang L. (Biochemistry 2007) 3 4
  5. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC- associated Brcc36 and proteasomal Poh1. (PMID: 19214193) Cooper E.M. … Cohen R.E. (EMBO J. 2009) 3 4

Products for PSMD14 Gene

Sources for PSMD14 Gene

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