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Aliases for PSMD12 Gene

Aliases for PSMD12 Gene

  • Proteasome 26S Subunit, Non-ATPase 12 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 12 2 3
  • 26S Proteasome Regulatory Subunit RPN5 3 4
  • 26S Proteasome Regulatory Subunit P55 3 4
  • Proteasome 26S Subunit Non-ATPase 12 3
  • Rpn5 3
  • P55 3

External Ids for PSMD12 Gene

Previous GeneCards Identifiers for PSMD12 Gene

  • GC17P062966
  • GC17P066117
  • GC17M065751
  • GC17M065885
  • GC17M065886
  • GC17M062764
  • GC17M065334
  • GC17M060723

Summaries for PSMD12 Gene

Entrez Gene Summary for PSMD12 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

GeneCards Summary for PSMD12 Gene

PSMD12 (Proteasome 26S Subunit, Non-ATPase 12) is a Protein Coding gene. Among its related pathways are Cell Cycle Checkpoints and Mitotic Metaphase and Anaphase.

UniProtKB/Swiss-Prot for PSMD12 Gene

  • Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

Gene Wiki entry for PSMD12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD12 Gene

Genomics for PSMD12 Gene

Regulatory Elements for PSMD12 Gene

Enhancers for PSMD12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSMD12 on UCSC Golden Path with GeneCards custom track

Promoters for PSMD12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSMD12 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSMD12 Gene

67,337,916 bp from pter
67,366,627 bp from pter
28,712 bases
Minus strand

Genomic View for PSMD12 Gene

Genes around PSMD12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD12 Gene

Proteins for PSMD12 Gene

  • Protein details for PSMD12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 12
    Protein Accession:
    Secondary Accessions:
    • A6NP15
    • Q53HA2
    • Q6P053

    Protein attributes for PSMD12 Gene

    456 amino acids
    Molecular mass:
    52904 Da
    Quaternary structure:
    • Component of the PA700 complex.
    • Sequence=AAH65826.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PSMD12 Gene


neXtProt entry for PSMD12 Gene

Proteomics data for PSMD12 Gene at MOPED

Post-translational modifications for PSMD12 Gene

  • Ubiquitination at Lys 52, Lys 121, Lys 212, and Lys 330
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMD12 Gene

No data available for DME Specific Peptides for PSMD12 Gene

Domains & Families for PSMD12 Gene

Gene Families for PSMD12 Gene

Protein Domains for PSMD12 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PCI domain.
  • Belongs to the proteasome subunit p55 family.
  • Contains 1 PCI domain.
  • Belongs to the proteasome subunit p55 family.
genes like me logo Genes that share domains with PSMD12: view

Function for PSMD12 Gene

Molecular function for PSMD12 Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
genes like me logo Genes that share phenotypes with PSMD12: view

Animal Model Products

miRNA for PSMD12 Gene

miRTarBase miRNAs that target PSMD12

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD12 Gene

Localization for PSMD12 Gene

Subcellular locations from

Jensen Localization Image for PSMD12 Gene COMPARTMENTS Subcellular localization image for PSMD12 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 3
peroxisome 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PSMD12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0031595 nuclear proteasome complex IBA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PSMD12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD12 Gene

Pathways & Interactions for PSMD12 Gene

SuperPathways for PSMD12 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 Interleukin-3, 5 and GM-CSF signaling
3 Infectious disease
4 Immune System
5 Cell Cycle, Mitotic
genes like me logo Genes that share pathways with PSMD12: view

Gene Ontology (GO) - Biological Process for PSMD12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSMD12: view

No data available for SIGNOR curated interactions for PSMD12 Gene

Drugs & Compounds for PSMD12 Gene

(2) Drugs for PSMD12 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 776
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMD12: view

Transcripts for PSMD12 Gene

Unigene Clusters for PSMD12 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD12 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
SP1: -
SP2: - - -
SP3: - - - -
SP4: - -

Relevant External Links for PSMD12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSMD12 Gene

mRNA expression in normal human tissues for PSMD12 Gene

Protein differential expression in normal tissues from HIPED for PSMD12 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMD12 Gene

SOURCE GeneReport for Unigene cluster for PSMD12 Gene Hs.592689

genes like me logo Genes that share expression patterns with PSMD12: view

Protein tissue co-expression partners for PSMD12 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMD12 Gene

Orthologs for PSMD12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PSMD12 35
  • 93.57 (n)
  • 99.34 (a)
PSMD12 36
  • 99 (a)
(Canis familiaris)
Mammalia PSMD12 35
  • 93.57 (n)
  • 99.34 (a)
PSMD12 36
  • 99 (a)
(Mus musculus)
Mammalia Psmd12 35
  • 88.16 (n)
  • 97.59 (a)
Psmd12 16
Psmd12 36
  • 98 (a)
(Pan troglodytes)
Mammalia PSMD12 35
  • 99.85 (n)
  • 100 (a)
PSMD12 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Psmd12 35
  • 88.38 (n)
  • 98.03 (a)
(Monodelphis domestica)
Mammalia PSMD12 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia PSMD12 36
  • 97 (a)
(Gallus gallus)
Aves LOC100859465 35
  • 82.31 (n)
  • 93.86 (a)
PSMD12 36
  • 94 (a)
PSMD12 36
  • 94 (a)
(Anolis carolinensis)
Reptilia PSMD12 36
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7238 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6202 35
(Danio rerio)
Actinopterygii Dr.20347 35
psmd12 35
  • 74.34 (n)
  • 86.84 (a)
psmd12 36
  • 87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9016 35
fruit fly
(Drosophila melanogaster)
Insecta Rpn5 37
  • 47 (a)
Rpn5 35
  • 54.95 (n)
  • 53.42 (a)
Rpn5 36
  • 47 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005535 35
  • 55.71 (n)
  • 57.08 (a)
(Caenorhabditis elegans)
Secernentea rpn-5 35
  • 52.5 (n)
  • 47.65 (a)
rpn-5 36
  • 43 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR073W 35
  • 51.35 (n)
  • 44.11 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C16313g 35
  • 51.58 (n)
  • 43.19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN5 35
  • 50.8 (n)
  • 42.07 (a)
RPN5 36
  • 42 (a)
RPN5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons RPN5B 35
  • 52.37 (n)
  • 47.95 (a)
(Oryza sativa)
Liliopsida Os03g0851300 35
  • 51.92 (n)
  • 46.68 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8739 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02650 35
  • 53.92 (n)
  • 48.85 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpn501 35
  • 52.59 (n)
  • 45.24 (a)
Species with no ortholog for PSMD12:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMD12 Gene

Gene Tree for PSMD12 (if available)
Gene Tree for PSMD12 (if available)

Paralogs for PSMD12 Gene Pseudogenes for PSMD12 Gene

genes like me logo Genes that share paralogs with PSMD12: view

No data available for Paralogs for PSMD12 Gene

Variants for PSMD12 Gene

Sequence variations from dbSNP and Humsavar for PSMD12 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2230680 - 67,344,616(-) CAGAG(C/T)TGTTG downstream-variant-500B, reference, missense
rs1803017 -- 67,340,879(-) CATCT(C/T)ATAGC reference, synonymous-codon
rs1137863 -- 67,358,485(-) gctca(A/G)gccag intron-variant
rs1137864 -- 67,358,465(-) TCAGC(C/T)TCCAG intron-variant
rs1137865 -- 67,358,446(-) ggact(A/G)cgggt intron-variant

Variation tolerance for PSMD12 Gene

Residual Variation Intolerance Score: 22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for PSMD12 Gene

Disorders for PSMD12 Gene

Relevant External Links for PSMD12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PSMD12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMD12 Gene

Publications for PSMD12 Gene

  1. cDNA cloning and functional analysis of p44.5 and p55, two regulatory subunits of the 26S proteasome. (PMID: 9426256) Saito A. … Tanaka K. (Gene 1997) 2 3 4 67
  2. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  3. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for PSMD12 Gene

Sources for PSMD12 Gene