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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PSMD12 Gene

protein-coding   GIFtS: 61
GCID: GC17M065334

Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase,...

Microbiology & Infectious Diseases Congress
  Search for PSMD12
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 121 2
26S Proteasome Regulatory Subunit P552 3
26S Proteasome Regulatory Subunit RPN52 3
26S Proteasome Non-ATPase Regulatory Subunit 122
Rpn52
p552

External Ids:    HGNC: 95571   Entrez Gene: 57182   Ensembl: ENSG000001971707   OMIM: 6044505   UniProtKB: O002323   

Export aliases for PSMD12 gene to outside databases

Previous GC identifers: GC17P062966 GC17P066117 GC17M065751 GC17M065885 GC17M065886 GC17M062764 GC17M060723


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PSMD12 Gene:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes,
a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are
composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a
base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in
an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome,
the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the
19S regulator. A pseudogene has been identified on chromosome 3. (provided by RefSeq, Jul 2008)

GeneCards Summary for PSMD12 Gene: 
PSMD12 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 12) is a protein-coding gene. Among its related super-pathways are Regulation of APC/C activators between G1/S and early anaphase and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway.

UniProtKB/Swiss-Prot: PSD12_HUMAN, O00232
Function: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of
ubiquitinated proteins

Gene Wiki entry for PSMD12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PSMD12 gene promoter:
         Pax-5   ATF-2   HSF1 (long)   FOXO3   Egr-4   FOXO3b   HEN1   CRE-BP1   FOXO3a   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSMD12 promoter sequence
   Search SABiosciences Chromatin IP Primers for PSMD12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSMD12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.2   Ensembl cytogenetic band:  17q24.2   HGNC cytogenetic band: 17q24.3

PSMD12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMD12 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M065334:  view genomic region     (about GC identifiers)

Start:
65,334,032 bp from pter      End:
65,362,743 bp from pter
Size:
28,712 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PSD12_HUMAN, O00232 (See protein sequence)
Recommended Name: 26S proteasome non-ATPase regulatory subunit 12  
Size: 456 amino acids; 52904 Da
Subunit: Component of the PA700 complex
Sequence caution: Sequence=AAH65826.1; Type=Erroneous initiation;
Secondary accessions: A6NP15 Q53HA2 Q6P053
Alternative splicing: 2 isoforms:  O00232-1   O00232-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PSMD12: NX_O00232

Explore proteomics data for PSMD12 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00232

  • PSMD12 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PSMD12 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002807.1  NP_777360.1  

    ENSEMBL proteins: 
     ENSP00000348442   ENSP00000349667   ENSP00000462525   ENSP00000463017  
    Reactome Protein details: O00232
    Human Recombinant Protein Products for PSMD12: 
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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0005838proteasome regulatory particle TAS9426256
    GO:0022624proteasome accessory complex ISS--

    PSMD12 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PSM: Proteasome (prosome, macropain) subunits

    2 InterPro protein domains:
     IPR000717 PCI_dom
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry O00232

    ProtoNet protein and cluster: O00232

    1 Blocks protein domain: IPB000717 Domain in components of the proteasome

    UniProtKB/Swiss-Prot: PSD12_HUMAN, O00232
    Similarity: Belongs to the proteasome subunit p55 family
    Similarity: Contains 1 PCI domain


    PSMD12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PSD12_HUMAN, O00232
    Function: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of
    ubiquitinated proteins

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    PSMD12 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PSMD12:
     Decreased homologous recombina  Decreased viability  Decreased viability of wild-ty  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PSMD12 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PSMD12 About   (see all 22)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    APC/C:Cdc20 mediated degradation of mitotic proteins0.94
    Removal of licensing factors from origins0.89
    Cdc20:Phospho-APC/C mediated degradation of Cyclin A0.94
    Regulation of DNA replication0.89
    CDK-mediated phosphorylation and removal of Cdc60.94
    Cyclin E associated events during G1/S transition 0.89
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    Switching of origins to a post-replicative state0.89
    2Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    4Metabolism of mRNA
    Metabolism of RNA0.92
    Metabolism of mRNA0.92
    5Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for PSMD12
        Immune response Antigen presentation by MHC class I
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PSMD12
        Remodeling of Adherens Junctions
    RAR-Gamma-RXR-Alpha Degradation

    3 GeneGo (Thomson Reuters) Pathways for PSMD12
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Antigen presentation by MHC class I

    3 BioSystems Pathways for PSMD12
        Parkin-Ubiquitin Proteasomal System pathway
    Proteasome Degradation
    TNF-alpha/NF-kB Signaling Pathway


    5/74        Reactome Pathways for PSMD12 (see all 74)
        Orc1 removal from chromatin
    CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway
    CDT1 association with the CDC6:ORC:origin complex
    Autodegradation of the E3 ubiquitin ligase COP1


    2         Kegg Pathways  (Kegg details for PSMD12):
        Proteasome
    Epstein-Barr virus infection


    PSMD12 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PSMD12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/986 Interacting proteins for PSMD12 (O002322, 3 ENSP000003484424) via UniProtKB, MINT, STRING, and/or I2D (see all 986)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMC1P621912, 3, ENSP000002613034MINT-4050722 MINT-7945693 MINT-7230300 MINT-7947479 I2D: score=6 STRING: ENSP00000261303
    PSMC4P436862, 3, ENSP000001578124MINT-4050722 MINT-7945693 MINT-7230300 MINT-7947479 I2D: score=6 STRING: ENSP00000157812
    PSMC3P179802, 3, ENSP000002988524MINT-4050722 MINT-7945693 MINT-7230300 MINT-7947479 I2D: score=5 STRING: ENSP00000298852
    PSMC5P621952, 3, ENSP000003105724MINT-4050722 MINT-7945693 MINT-7230300 MINT-7947479 I2D: score=5 STRING: ENSP00000310572
    ENSG00000096150P622692, 3MINT-7945693 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--

    PSMD12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PSMD12 (PSD12)

    Search CenterWatch for drugs/clinical trials and news about PSMD12 / PSD12

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PSMD12 gene (2 alternative transcripts): 
    NM_002816.3  NM_174871.2  

    Unigene Cluster for PSMD12:

    Proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
    Hs.592689  [show with all ESTs]
    Unigene Representative Sequence: AB003103
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356126(uc002jfy.3 uc002jfz.3) ENST00000357146(uc002jga.3)
    ENST00000584008 ENST00000577724 ENST00000584289(uc010det.1) ENST00000581618
    ENST00000579365 ENST00000578015
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate PSMD12:
    hsa-miR-548d-3p hsa-miR-425 hsa-miR-570
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    Additional mRNA sequence: 

    AB003103.1 AK091198.1 AK222679.1 AK307821.1 AK308883.1 BC019062.2 BC065826.1 

    9 DOTS entries:

    DT.454486  DT.100794536  DT.100794535  DT.95113349  DT.120911005  DT.95260363  DT.92435133  DT.95113346 
    DT.95221100 

    24/277 AceView cDNA sequences (see all 277):

    BQ185355 BQ086271 BQ723462 AA766215 AW261989 AA250960 BQ434380 BM474116 
    BQ961419 NM_174871 AI378670 AA328244 AA479897 BM554816 BM705583 BQ958333 
    BQ015279 BE465345 AI191461 BC065826 BI255795 BQ102364 BU616916 BQ086171 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PSMD12    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
    SP1:                                                  -                                                                           
    SP2:                          -     -                 -                                                                           
    SP3:                          -     -     -           -                                                                           
    SP4:                          -     -                                                                                             
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for PSMD12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PSMD12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGATCCTA
    PSMD12 Expression
    About this image


    See PSMD12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PSMD12

    SOURCE GeneReport for Unigene cluster: Hs.592689
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PSMD12 gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Psmd121 , 5 proteasome (prosome, macropain) 26S subunit, non-ATPase, more1, 5 88.16(n)1
    97.59(a)1
      11 (70.29 cM)5
    669971  NM_025894.21  NP_080170.11 
     1074794845 
    chicken
    (Gallus gallus)
    Aves LOC1008594651 26S proteasome non-ATPase regulatory subunit 12-like 82.31(n)
    93.86(a)
      100859465  XM_003642339.1  XP_003642387.1 
    lizard
    (Anolis carolinensis)
    Reptilia PSMD126
    Uncharacterized protein
    93(a)
    1 ↔ 1
    GL343250.1(674851-689170)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.62022 Xenopus laevis, Similar to proteasome (prosome, macropain) more 78.46(n)    BC045091.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.203472 Danio rerio mRNA similar to proteasome (prosome, macropain) more 75.62(n)    BC042325.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rpn51 , 3 proteolysis and peptidolysis proteasome
    endopeptidase3
    CG1100-PA1
    47(a)3
    54.64(n)1
    52.74(a)1
      83C43
    407171  NM_141331.21  NP_649588.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rpn-51 Protein RPN-5 52.45(n)
    47.4(a)
      173807  NM_062434.2  NP_494835.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPN5(YDL147W)4
    RPN51
    Subunit of the COP9 signalosome (CSN) and non-ATPase more4
    Rpn5p1
    50.88(n)1
    42.07(a)1
      4(190924-192261)4
    8514081, 4  NP_010134.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RPN5B1 26S proteasome regulatory subunit N5 52.37(n)
    47.95(a)
      836597  NM_001037065.2  NP_001032142.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g08513001 hypothetical protein 51.68(n)
    45.95(a)
      4334802  NM_001058449.1  NP_001051914.1 


    ENSEMBL Gene Tree for PSMD12 (if available)
    TreeFam Gene Tree for PSMD12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PSMD12 gene

    PSMD12 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PSMD12
    PGOHUM00000240657 PGOHUM00000237648


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/594 SNPs in PSMD12 are shown (see all 594)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs346398261,2
    C--65336206(+) AGAGCA/-aaaaa 2 -- ds50011Minor allele frequency- -:0.00NA 2
    rs1437454411,2
    --65336336(+) AAGCAA/GTCAAG 2 -- ds50010--------
    rs1481461871,2
    --65336342(+) TCAAGC/TTACTG 2 -- ds50010--------
    rs58214781,2
    C--65336369(-) TTTTT-/T/TT  
            
    GAGTC
    2 -- ds50011CSA 2
    rs574425691,2
    C--65336386(+) AAAAA-/A/A   
       A
    /AAA
    GTCTA
    4 -- ds5001 cds11NA 2
    rs620859981,2
    C,F--65336473(+) CTATCC/TCAAAT 2 -- ds50017Minor allele frequency- T:0.16NA WA CSA EA 366
    rs129367221,2
    C,H--65336486(+) TCTTGT/GATGCT 2 -- ds5001 ese35Minor allele frequency- G:0.00NS EA NA 420
    rs39357321,2
    C,F,A,H--65336527(+) TGATAG/ACTTTA 2 -- ds500122Minor allele frequency- A:0.43NS EA NA WA CSA 2255
    rs1893921411,2
    --65336574(+) ATCACC/TACCCC 2 -- ds50010--------
    rs1815804121,2
    --65336750(+) CAGACC/GACAGA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for PSMD12 (65334032 - 65362743 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PSMD12: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PSMD12
    DNA2.0 Custom Variant and Variant Library Synthesis for PSMD12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PSMD12 for disorders           About MalaCards
    OMIM gene information: 604450    OMIM disorders: --


    PSMD12 for disorders           About GeneDecksing


    Export disorders for PSMD12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PSMD12 gene, integrated from 9 sources (see all 80):
    (articles sorted by number of sources associating them with PSMD12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and functional analysis of p44.5 and p55, two regulatory subunits of the 26S proteasome. (PubMed id 9426256)1, 2, 3 Saito A.... Tanaka K. (1997)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    5. Quantitative study of the interactome of PKCz involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (2013)
    6. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    7. RNF111/Arkadia is a SUMO-targeted ubiquitin ligase tha t facilitates the DNA damage response. (PubMed id 23751493)1 Poulsen S.L....Mailand N. (2013)
    8. Proteomic analysis of the NOS2 interactome in human ai rway epithelial cells. (PubMed id 23438482)1 Foster M.W....Marshall H.E. (2013)
    9. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5718 HGNC: 9557 AceView: PSMD12 Ensembl:ENSG00000197170 euGenes: HUgn5718
    ECgene: PSMD12 Kegg: 5718 H-InvDB: PSMD12

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PSMD12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PSMD12 gene:
    Search GeneIP for patents involving PSMD12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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