Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PSMD12 Gene

protein-coding   GIFtS: 63
GCID: GC17M065334

Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase,...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 121 2
26S Proteasome Regulatory Subunit P552 3
26S Proteasome Regulatory Subunit RPN52 3
26S Proteasome Non-ATPase Regulatory Subunit 122
Rpn52
p552

External Ids:    HGNC: 95571   Entrez Gene: 57182   Ensembl: ENSG000001971707   OMIM: 6044505   UniProtKB: O002323   

Export aliases for PSMD12 gene to outside databases

Previous GC identifers: GC17P062966 GC17P066117 GC17M065751 GC17M065885 GC17M065886 GC17M062764 GC17M060723


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PSMD12 Gene:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes,
a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are
composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a
base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in
an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome,
the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the
19S regulator. A pseudogene has been identified on chromosome 3. (provided by RefSeq, Jul 2008)

GeneCards Summary for PSMD12 Gene:
PSMD12 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 12) is a protein-coding gene. Diseases associated with PSMD12 include hiv-1, and neuroblastoma.

UniProtKB/Swiss-Prot: PSD12_HUMAN, O00232
Function: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of
ubiquitinated proteins

Gene Wiki entry for PSMD12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PSMD12 gene promoter:
         Pax-5   ATF-2   HSF1 (long)   FOXO3   Egr-4   FOXO3b   HEN1   CRE-BP1   FOXO3a   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSMD12 promoter sequence
   Search Chromatin IP Primers for PSMD12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSMD12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.2   Ensembl cytogenetic band:  17q24.2   HGNC cytogenetic band: 17q24.3

PSMD12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMD12 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M065334:  view genomic region     (about GC identifiers)

Start:
65,334,032 bp from pter      End:
65,362,743 bp from pter
Size:
28,712 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PSD12_HUMAN, O00232 (See protein sequence)
Recommended Name: 26S proteasome non-ATPase regulatory subunit 12  
Size: 456 amino acids; 52904 Da
Subunit: Component of the PA700 complex
Sequence caution: Sequence=AAH65826.1; Type=Erroneous initiation;
Secondary accessions: A6NP15 Q53HA2 Q6P053
Alternative splicing: 2 isoforms:  O00232-1   O00232-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PSMD12: NX_O00232

Explore proteomics data for PSMD12 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys52, Lys92, Lys121, Lys212, Lys330, Lys448
  • Modification sites at PhosphoSitePlus

  • See PSMD12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002807.1  NP_777360.1  

    ENSEMBL proteins: 
     ENSP00000348442   ENSP00000349667   ENSP00000462525   ENSP00000463017  
    Reactome Protein details: O00232

    PSMD12 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PSMD12
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PSMD12
    GenScript Custom Purified and Recombinant Proteins Services for PSMD12
    Novus Biologicals PSMD12 Proteins
    Novus Biologicals PSMD12 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PSMD12

    PSMD12 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PSMD12
    OriGene Custom Antibody Services for PSMD12
    Novus Biologicals PSMD12 Antibodies
    Abcam antibodies for PSMD12
    Cloud-Clone Corp. Antibodies for PSMD12
    ThermoFisher Antibodies for PSMD12
    LSBio Antibodies in human, mouse, rat for PSMD12

    PSMD12 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PSMD12
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PSMD12
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PSMD12
    Cloud-Clone Corp. CLIAs for PSMD12


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PSM: Proteasome (prosome, macropain) subunits

    2 InterPro protein domains:
     IPR000717 PCI_dom
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry O00232

    ProtoNet protein and cluster: O00232

    1 Blocks protein domain: IPB000717 Domain in components of the proteasome

    UniProtKB/Swiss-Prot: PSD12_HUMAN, O00232
    Similarity: Belongs to the proteasome subunit p55 family
    Similarity: Contains 1 PCI domain


    PSMD12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PSD12_HUMAN, O00232
    Function: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of
    ubiquitinated proteins

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    PSMD12 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PSMD12:
     Decreased homologous recombina  Decreased viability  Decreased viability of wild-ty  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PSMD12
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PSMD12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PSMD12
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PSMD12

    miRNA
    Products:
        
    miRTarBase miRNAs that target PSMD12:
    hsa-mir-132-3p (MIRT021773), hsa-mir-16-5p (MIRT031616), hsa-mir-142-3p (MIRT021584)

    Block miRNA regulation of human, mouse, rat PSMD12 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate PSMD12:
    hsa-miR-548d-3p hsa-miR-425 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidPSMD12 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PSMD12
    Predesigned siRNA for gene silencing in human, mouse, rat PSMD12

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PSMD12

    Clone
    Products:
         
    OriGene clones in human, mouse for PSMD12 (see all 12)
    OriGene ORF clones in mouse, rat for PSMD12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PSMD12 (NM_002816)
    Sino Biological Human cDNA Clone for PSMD12
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSMD12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMD12

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PSMD12
    Browse ESI BIO Cell Lines and PureStem Progenitors for PSMD12 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMD12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    peroxisome2
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0005838proteasome regulatory particle TAS9426256
    GO:0022624proteasome accessory complex ISS--
    GO:0070062extracellular vesicular exosome IDA19056867

    PSMD12 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PSMD12 About   (see all 19)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    CDK-mediated phosphorylation and removal of Cdc60.94
    Destabilization of mRNA by AUF1 (hnRNP D0)0.88
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    G1/S DNA Damage Checkpoints0.87
    Ubiquitin-dependent degradation of Cyclin D10.94
    CDT1 association with the CDC6-ORC-origin complex0.87
    Ubiquitin-dependent degradation of Cyclin D0.94
    SCF(Skp2)-mediated degradation of p27/p210.86
    2Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PSMD12
        Remodeling of Adherens Junctions
    RAR-Gamma-RXR-Alpha Degradation

    3 GeneGo (Thomson Reuters) Pathways for PSMD12
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Antigen presentation by MHC class I

    3 BioSystems Pathways for PSMD12
        Parkin-Ubiquitin Proteasomal System pathway
    Proteasome Degradation
    TNF-alpha/NF-kB Signaling Pathway


    Selected Reactome Pathways for PSMD12 (see all 24)
        SCF(Skp2)-mediated degradation of p27/p21
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
    SCF-beta-TrCP mediated degradation of Emi1
    Ubiquitin-dependent degradation of Cyclin D1
    Orc1 removal from chromatin


    2 Kegg Pathways  (Kegg details for PSMD12):
        Proteasome
    Epstein-Barr virus infection


    PSMD12 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PSMD12
    Interactions:

        Search GeneGlobe Interaction Network for PSMD12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PSMD12 (O002322, 3 ENSP000003484424) via UniProtKB, MINT, STRING, and/or I2D (see all 1037)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMC1P621912, 3, ENSP000002613034MINT-4050722 MINT-7945693 MINT-7230300 MINT-7947479 I2D: score=6 STRING: ENSP00000261303
    PSMC4P436862, 3, ENSP000001578124MINT-4050722 MINT-7945693 MINT-7230300 MINT-7947479 I2D: score=6 STRING: ENSP00000157812
    PSMC3P179802, 3, ENSP000002988524MINT-4050722 MINT-7945693 MINT-7230300 MINT-7947479 I2D: score=5 STRING: ENSP00000298852
    PSMC5P621952, 3, ENSP000003105724MINT-4050722 MINT-7945693 MINT-7230300 MINT-7947479 I2D: score=5 STRING: ENSP00000310572
    ENSG00000096150P622692, 3MINT-7945693 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--

    PSMD12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PSMD12 (PSD12)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PSMD12 gene (2 alternative transcripts): 
    NM_002816.3  NM_174871.2  

    Unigene Cluster for PSMD12:

    Proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
    Hs.592689  [show with all ESTs]
    Unigene Representative Sequence: AB003103
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356126(uc002jfy.3 uc002jfz.3) ENST00000357146(uc002jga.3)
    ENST00000584008 ENST00000577724 ENST00000584289(uc010det.1) ENST00000581618
    ENST00000579365 ENST00000578015
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PSMD12 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate PSMD12:
    hsa-miR-548d-3p hsa-miR-425 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidPSMD12 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PSMD12
    Predesigned siRNA for gene silencing in human, mouse, rat PSMD12
    Clone
    Products:
         
    OriGene clones in human, mouse for PSMD12 (see all 12)
    OriGene ORF clones in mouse, rat for PSMD12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PSMD12 (NM_002816)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSMD12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMD12
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PSMD12
    OriGene qSTAR qPCR primer pairs in human, mouse for PSMD12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PSMD12
      QuantiTect SYBR Green Assays in human, mouse, rat PSMD12
      QuantiFast Probe-based Assays in human, mouse, rat PSMD12

    Additional mRNA sequence: 

    AB003103.1 AK091198.1 AK222679.1 AK307821.1 AK308883.1 BC019062.2 BC065826.1 

    9 DOTS entries:

    DT.454486  DT.100794536  DT.100794535  DT.95113349  DT.120911005  DT.95260363  DT.92435133  DT.95113346 
    DT.95221100 

    Selected AceView cDNA sequences (see all 277):

    NM_174871 AI080251 BQ086171 BM782054 BU609078 BC065826 AX746843 AA766215 
    CR621959 AA250960 Z40312 BF002834 BQ185355 AK091198 CB242390 BC019062 
    AA479897 AA328244 AI198426 AI401315 BM683310 BQ958333 BQ017962 CR603290 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PSMD12    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
    SP1:                                                  -                                                                           
    SP2:                          -     -                 -                                                                           
    SP3:                          -     -     -           -                                                                           
    SP4:                          -     -                                                                                             
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for PSMD12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PSMD12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGATCCTA
    PSMD12 Expression
    About this image

    PSMD12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PSMD12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592689
        Custom PCR Arrays for PSMD12
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PSMD12
    OriGene qSTAR qPCR primer pairs in human, mouse for PSMD12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PSMD12
    QuantiTect SYBR Green Assays in human, mouse, rat PSMD12
    QuantiFast Probe-based Assays in human, mouse, rat PSMD12
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMD12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PSMD12 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Psmd121 , 5 proteasome (prosome, macropain) 26S subunit, non-ATPase, more1, 5 88.16(n)1
    97.59(a)1
      11 (70.29 cM)5
    669971  NM_025894.21  NP_080170.11 
     1074794845 
    chicken
    (Gallus gallus)
    Aves LOC1008594651 26S proteasome non-ATPase regulatory subunit 12-like 82.31(n)
    93.86(a)
      100859465  XM_003642339.2  XP_003642387.1 
    lizard
    (Anolis carolinensis)
    Reptilia PSMD126
    proteasome (prosome, macropain) 26S subunit, non-A...
    93(a)
    1 ↔ 1
    GL343250.1(674851-689170)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.62022 Xenopus laevis, Similar to proteasome (prosome, macropain) more 78.46(n)    BC045091.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.203472 Danio rerio mRNA similar to proteasome (prosome, macropain) more 75.62(n)    BC042325.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rpn51 , 3 proteolysis and peptidolysis proteasome
    endopeptidase3
    Regulatory particle non-ATPase 51
    47(a)3
    54.95(n)1
    53.42(a)1
      83C43
    407171  NM_141331.31  NP_649588.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rpn-51 rpn-5 52.5(n)
    47.65(a)
      173807  NM_062434.3  NP_494835.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPN5(YDL147W)4
    RPN51
    Subunit of the COP9 signalosome (CSN) and non-ATPase more4
    RPN51
    50.8(n)1
    42.07(a)1
      4(190924-192261)4
    8514081, 4  NP_010134.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RPN5B1 RPN5B 52.37(n)
    47.95(a)
      836597  NM_001037065.2  NP_001032142.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g08513001 Os03g0851300 51.92(n)
    46.68(a)
      4334802  NM_001058449.1  NP_001051914.1 


    ENSEMBL Gene Tree for PSMD12 (if available)
    TreeFam Gene Tree for PSMD12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PSMD12 gene

    PSMD12 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PSMD12
    PGOHUM00000240657 PGOHUM00000237648


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PSMD12 (see all 594)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs346398261,2
    C--65336206(+) AGAGCA/-aaaaa 2 -- ds50011Minor allele frequency- -:0.00NA 2
    rs1437454411,2
    --65336336(+) AAGCAA/GTCAAG 2 -- ds50010--------
    rs1481461871,2
    --65336342(+) TCAAGC/TTACTG 2 -- ds50010--------
    rs58214781,2
    C--65336369(-) TTTTT-/T/TT  
            
    GAGTC
    2 -- ds50011CSA 2
    rs574425691,2
    C--65336386(+) AAAAA-/A/A   
       A
    /AAA
    GTCTA
    4 -- ds5001 cds11NA 2
    rs620859981,2
    C,F--65336473(+) CTATCC/TCAAAT 2 -- ds50017Minor allele frequency- T:0.16NA WA CSA EA 366
    rs129367221,2
    C,H--65336486(+) TCTTGT/GATGCT 2 -- ds5001 ese35Minor allele frequency- G:0.00NS EA NA 420
    rs39357321,2
    C,F,A,H--65336527(+) TGATAG/ACTTTA 2 -- ds500122Minor allele frequency- A:0.43NS EA NA WA CSA 2255
    rs1893921411,2
    --65336574(+) ATCACC/TACCCC 2 -- ds50010--------
    rs1815804121,2
    --65336750(+) CAGACC/GACAGA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for PSMD12 (65334032 - 65362743 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PSMD12: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PSMD12
    DNA2.0 Custom Variant and Variant Library Synthesis for PSMD12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604450    OMIM disorders: --

    3 diseases for PSMD12:    
    About MalaCards
    hiv-1    neuroblastoma    malaria


    PSMD12 for disorders           About GeneDecksing


    Export disorders for PSMD12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PSMD12 gene, integrated from 10 sources (see all 83):
    (articles sorted by number of sources associating them with PSMD12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and functional analysis of p44.5 and p55, two regulatory subunits of the 26S proteasome. (PubMed id 9426256)1, 2, 3 Saito A.... Tanaka K. (Gene 1997)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    5. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response. (PubMed id 23751493)1 Poulsen S.L....Mailand N. (J. Cell Biol. 2013)
    8. Proteomic analysis of the NOS2 interactome in human airway epithelial cells. (PubMed id 23438482)1 Foster M.W....Marshall H.E. (Nitric Oxide 2013)
    9. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    10. Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. (PubMed id 23503661)1 Sarraf S.A....Harper J.W. (Nature 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5718 HGNC: 9557 AceView: PSMD12 Ensembl:ENSG00000197170 euGenes: HUgn5718
    ECgene: PSMD12 Kegg: 5718 H-InvDB: PSMD12

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PSMD12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PSMD12 gene:
    Search GeneIP for patents involving PSMD12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PSMD12   OriGene RNAi products in human, mouse, rat for PSMD12  
     OriGene qPCR primer pairs and template standards for PSMD12   OriGene Protein Over-expression Lysate for PSMD12  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PSMD12  
     OriGene qSTAR qPCR primer pairs in human, mouse for PSMD12   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PSMD12   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PSMD12   OriGene Custom Protein Services for PSMD12  

     
     
     Block miRNA regulation of human, mouse, rat PSMD12 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PSMD12
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSMD12 Predesigned siRNA for gene silencing in human, mouse, rat PSMD12
     QuantiFast Probe-based Assays in human, mouse, rat PSMD12 QuantiTect SYBR Green Assays in human, mouse, rat PSMD12
     Custom PCR Arrays for PSMD12 Search Chromatin IP Primers for PSMD12
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PSMD12  Search GeneGlobe Interaction Network for PSMD12
     Regulatory tfbs in PSMD12 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PSMD12 GenScript cDNA clones with any tag delivered in your preferred vector for PSMD12
     GenScript Custom Assay Services for PSMD12 GenScript Custom overexpressing Cell Line Services for PSMD12
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PSMD12 (PSD12)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for PSMD12
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PSMD12 antibodies
     PSMD12 proteins
     PSMD12 lysates
     Antibodies for PSMD12
     See all of Abcam's Antibodies, Kits and Proteins for PSMD12
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PSMD12
     Antibodies for PSMD12
     ELISAs for PSMD12
     CLIAs for PSMD12



     Browse ESI BIO Cell Lines and PureStem Progenitors for PSMD12
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMD12
     SwitchGear 3'UTR luciferase reporter plasmids for PSMD12
     SwitchGear Promoter luciferase reporter plasmids for PSMD12
     ThermoFisher Antibodies for PSMD12
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMD12
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PSMD12
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PSMD12
     LSBio Antibodies in human, mouse, rat for PSMD12
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PSMD12 gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4