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Aliases for PSMD12 Gene

Aliases for PSMD12 Gene

  • Proteasome 26S Subunit, Non-ATPase 12 2 3
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 12 2 3
  • 26S Proteasome Regulatory Subunit RPN5 3 4
  • 26S Proteasome Regulatory Subunit P55 3 4
  • Rpn5 3
  • P55 3

External Ids for PSMD12 Gene

Previous GeneCards Identifiers for PSMD12 Gene

  • GC17P062966
  • GC17P066117
  • GC17M065751
  • GC17M065885
  • GC17M065886
  • GC17M062764
  • GC17M065334
  • GC17M060723

Summaries for PSMD12 Gene

Entrez Gene Summary for PSMD12 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

GeneCards Summary for PSMD12 Gene

PSMD12 (Proteasome 26S Subunit, Non-ATPase 12) is a Protein Coding gene. Among its related pathways are Immune System and Signaling by GPCR.

UniProtKB/Swiss-Prot for PSMD12 Gene

  • Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins

Gene Wiki entry for PSMD12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD12 Gene

Genomics for PSMD12 Gene

Regulatory Elements for PSMD12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PSMD12 Gene

Chromosome:
17
Start:
67,337,916 bp from pter
End:
67,366,627 bp from pter
Size:
28,712 bases
Orientation:
Minus strand

Genomic View for PSMD12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for PSMD12 Gene

Proteins for PSMD12 Gene

  • Protein details for PSMD12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00232-PSD12_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 12
    Protein Accession:
    O00232
    Secondary Accessions:
    • A6NP15
    • Q53HA2
    • Q6P053

    Protein attributes for PSMD12 Gene

    Size:
    456 amino acids
    Molecular mass:
    52904 Da
    Quaternary structure:
    • Component of the PA700 complex
    SequenceCaution:
    • Sequence=AAH65826.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PSMD12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD12 Gene

Proteomics data for PSMD12 Gene at MOPED

Post-translational modifications for PSMD12 Gene

  • Ubiquitination at Lys 52, Lys 121, Lys 212, and Lys 330
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMD12 Gene

Antibody Products

No data available for DME Specific Peptides for PSMD12 Gene

Domains & Families for PSMD12 Gene

Gene Families for PSMD12 Gene

Protein Domains for PSMD12 Gene

Graphical View of Domain Structure for InterPro Entry

O00232

UniProtKB/Swiss-Prot:

PSD12_HUMAN :
  • Contains 1 PCI domain.
  • Belongs to the proteasome subunit p55 family.
Domain:
  • Contains 1 PCI domain.
Family:
  • Belongs to the proteasome subunit p55 family.
genes like me logo Genes that share domains with PSMD12: view

Function for PSMD12 Gene

Molecular function for PSMD12 Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins

Gene Ontology (GO) - Molecular Function for PSMD12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PSMD12: view
genes like me logo Genes that share phenotypes with PSMD12: view

Animal Model Products

miRNA for PSMD12 Gene

miRTarBase miRNAs that target PSMD12

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMD12

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD12 Gene

Localization for PSMD12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMD12 Gene COMPARTMENTS Subcellular localization image for PSMD12 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 4
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for PSMD12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 17323924
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005838 proteasome regulatory particle TAS 9426256
GO:0008541 proteasome regulatory particle, lid subcomplex IBA --
genes like me logo Genes that share ontologies with PSMD12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD12 Gene

Pathways & Interactions for PSMD12 Gene

SuperPathways for PSMD12 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin receptor SHC signaling
3 Infectious disease
.53
4 Immune System
5 Downstream signaling events of B Cell Receptor (BCR)
genes like me logo Genes that share pathways with PSMD12: view

Gene Ontology (GO) - Biological Process for PSMD12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with PSMD12: view

No data available for SIGNOR curated interactions for PSMD12 Gene

Drugs & Compounds for PSMD12 Gene

(2) Drugs for PSMD12 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 758
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMD12: view

Transcripts for PSMD12 Gene

Unigene Clusters for PSMD12 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 12:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMD12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD12 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
SP1: -
SP2: - - -
SP3: - - - -
SP4: - -
SP5:

Relevant External Links for PSMD12 Gene

GeneLoc Exon Structure for
PSMD12
ECgene alternative splicing isoforms for
PSMD12

Expression for PSMD12 Gene

mRNA expression in normal human tissues for PSMD12 Gene

Protein differential expression in normal tissues from HIPED for PSMD12 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMD12 Gene



SOURCE GeneReport for Unigene cluster for PSMD12 Gene Hs.592689

genes like me logo Genes that share expression patterns with PSMD12: view

Protein tissue co-expression partners for PSMD12 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMD12 Gene

Orthologs for PSMD12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMD12 35
  • 93.57 (n)
  • 99.34 (a)
PSMD12 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMD12 35
  • 93.57 (n)
  • 99.34 (a)
PSMD12 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmd12 35
  • 88.16 (n)
  • 97.59 (a)
Psmd12 16
Psmd12 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSMD12 35
  • 99.85 (n)
  • 100 (a)
PSMD12 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmd12 35
  • 88.38 (n)
  • 98.03 (a)
oppossum
(Monodelphis domestica)
Mammalia PSMD12 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMD12 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859465 35
  • 82.31 (n)
  • 93.86 (a)
PSMD12 36
  • 94 (a)
OneToMany
PSMD12 36
  • 94 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia PSMD12 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7238 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6202 35
zebrafish
(Danio rerio)
Actinopterygii Dr.20347 35
psmd12 35
  • 74.34 (n)
  • 86.84 (a)
psmd12 36
  • 87 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9016 35
fruit fly
(Drosophila melanogaster)
Insecta Rpn5 37
  • 47 (a)
Rpn5 35
  • 54.95 (n)
  • 53.42 (a)
Rpn5 36
  • 47 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005535 35
  • 55.71 (n)
  • 57.08 (a)
worm
(Caenorhabditis elegans)
Secernentea rpn-5 35
  • 52.5 (n)
  • 47.65 (a)
rpn-5 36
  • 43 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR073W 35
  • 51.35 (n)
  • 44.11 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C16313g 35
  • 51.58 (n)
  • 43.19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN5 35
  • 50.8 (n)
  • 42.07 (a)
RPN5 36
  • 42 (a)
OneToOne
RPN5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons RPN5B 35
  • 52.37 (n)
  • 47.95 (a)
rice
(Oryza sativa)
Liliopsida Os03g0851300 35
  • 51.92 (n)
  • 46.68 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8739 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02650 35
  • 53.92 (n)
  • 48.85 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpn501 35
  • 52.59 (n)
  • 45.24 (a)
Species with no ortholog for PSMD12:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMD12 Gene

ENSEMBL:
Gene Tree for PSMD12 (if available)
TreeFam:
Gene Tree for PSMD12 (if available)

Paralogs for PSMD12 Gene

Pseudogenes.org Pseudogenes for PSMD12 Gene

genes like me logo Genes that share paralogs with PSMD12: view

No data available for Paralogs for PSMD12 Gene

Variants for PSMD12 Gene

Sequence variations from dbSNP and Humsavar for PSMD12 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs12938288 -- 67,358,588(+) aaaag(A/T)aaaga intron-variant
rs12942730 -- 67,352,100(+) aaaaa(A/T)ttttt intron-variant
rs12952954 -- 67,356,381(+) gtgaa(A/G)ccccg intron-variant
rs16960829 -- 67,354,517(+) CCTAA(C/T)ACTAC intron-variant
rs16960830 -- 67,366,155(+) GCAAA(A/G)AGTTA intron-variant

Variation tolerance for PSMD12 Gene

Residual Variation Intolerance Score: 22.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMD12 Gene

HapMap Linkage Disequilibrium report
PSMD12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PSMD12 Gene

Disorders for PSMD12 Gene

Relevant External Links for PSMD12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMD12
genes like me logo Genes that share disorders with PSMD12: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMD12 Gene

Publications for PSMD12 Gene

  1. Polyhomeotic stably associates with molecular chaperones Hsc4 and Droj2 in Drosophila Kc1 cells. (PMID: 14550797) Wang Y.J. … Brock H.W. (Dev. Biol. 2003) 23 67
  2. Identification of a host protein essential for assembly of immature HIV-1 capsids. (PMID: 11780123) Zimmerman C. … Lingappa J.R. (Nature 2002) 23 67
  3. cDNA cloning and functional analysis of p44.5 and p55, two regulatory subunits of the 26S proteasome. (PMID: 9426256) Saito A. … Tanaka K. (Gene 1997) 2 67
  4. Rational design of peptide-based HIV proteinase inhibitors. (PMID: 2183354) Roberts N.A. … KrAPhn A. (Science 1990) 23 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for PSMD12 Gene

Sources for PSMD12 Gene

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