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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PSMD11 Gene

protein-coding   GIFtS: 60
GCID: GC17P030771

proteasome (prosome, macropain) 26S subunit, non-ATPase,...
 Explore 2 diseases affiliated with
PSMD11 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PSMD11    

Aliases
for PSMD11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 111 2     26S Proteasome Regulatory Subunit RPN62 3
Rpn61 2     26S Proteasome Regulatory Subunit S92 3
S91 2     MGC38441
P44.51     26S Proteasome Non-ATPase Regulatory Subunit 112
26S Proteasome Regulatory Subunit P44.52 3     26S Proteasome Regulatory Subunit 92

External Ids:    HGNC: 95561   Entrez Gene: 57172   Ensembl: ENSG000001086717   OMIM: 6044495   UniProtKB: O002313   

Export aliases for PSMD11 gene to outside databases

Previous GC identifers: GC17P030538 GC17P032806 GC17P030917 GC17P027795 GC17P026958


Summaries
for PSMD11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PSMD11:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a
20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed
of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which
contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits.
Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an
ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9
family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein
kinase. Alternatively spliced transcript variants have been observed for this gene. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: PSD11_HUMAN, O00231
Function: Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent
degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in
increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly
of the 26S proteasome, followed by higher proteasome activity

Gene Wiki entry for PSMD11


Genomic Views
for PSMD11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PSMD11 gene promoter:
         AhR   STAT1   AP-1   Pax-5   p53   HTF   RORalpha2   POU2F1   POU2F1a   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PSMD11 promoter sequence
   Search SABiosciences Chromatin IP Primers for PSMD11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSMD11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q12

PSMD11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMD11 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P030771:  view genomic region     (about GC identifiers)

Start:
 30,771,279 bp from pter      End:
 30,810,336 bp from pter
Size:
 39,058 bases      Orientation:
 plus strand

Proteins
for PSMD11 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PSD11_HUMAN, O00231 (See protein sequence)
Recommended Name: 26S proteasome non-ATPase regulatory subunit 11  
Size: 422 amino acids; 47464 Da
Subunit: Component of the lid subcomplex of the 19S proteasome regulatory particle complex (also named PA700 complex).
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits
Subcellular location: Nucleus (By similarity). Cytoplasm, cytosol (By similarity)
Secondary accessions: A8K3I7 E1P663 O00495 Q53FT5
Alternative splicing: 2 isoforms:  O00231-1   O00231-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PSMD11: NX_O00231

Post-translational modifications:

  • Phosphorylated by AMPK1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00231

    • PSMD11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001257411.1  NP_002806.2  

    ENSEMBL proteins: 
     ENSP00000261712   ENSP00000462683   ENSP00000393185   ENSP00000464434   ENSP00000463728  
     ENSP00000464475  
    Reactome Protein details: O00231
    Human Recombinant Protein Products: 
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    Uscn Proteins for PSMD11

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex TAS9119060
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0022624proteasome accessory complex IDA--


    PSMD11 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PSMD11

    Protein Domains /
    Families
    for PSMD11 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PSMD11 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR011990 TPR-like_helical
     IPR013143 PAM
     IPR000717 PCI_dom
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry O00231

    ProtoNet protein and cluster: O00231

    1 Blocks protein family: IPB000717 Domain in components of the proteasome

    UniProtKB/Swiss-Prot: PSD11_HUMAN, O00231
    Similarity: Belongs to the proteasome subunit S9 family
    Similarity: Contains 1 PCI domain


    Function
    for PSMD11 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PSD11_HUMAN, O00231
    Function: Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent
    degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in
    increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly
    of the 26S proteasome, followed by higher proteasome activity
    Induction: By FOXO4; expression in embryonic stem cells (ESCs) is mediated by FOXO4

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate PSMD11:
    hsa-miR-4286 hsa-miR-548am hsa-miR-548x hsa-miR-4258
    SwitchGear 3'UTR luciferase reporter plasmid: PSMD11 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: PSMD11
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    Gene Editing
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    Clone
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    In Situ Assay
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    5 GenomeRNAi human phenotypes for PSMD11:
     Cell cycle / mitosis defect  Decreased viability of wild-ty  G0/1 arrest  Increased G1 DNA content 
     Metaphase cells 

    Animal Models:
         1 MGI phenotypic allele for Psmd11 (no phenotypes)

    PSMD11 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PSMD11 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitinated Orc1 is degraded by the proteasome
    8/76 pathways (see all 76)
    		Ubiquitinated Orc1 is degraded by the proteasome1.00
    		Assembly of the pre-replicative complex0.77
    		Proteasomal cleavage of substrate0.98
    		Degradation of ubiquitinated p27/p21 by the 26S proteasome0.75
    		Proteasome mediated degradation of PAK-2p340.98
    		SCF(Skp2)-mediated degradation of p27/p210.75
    		Proteasomal cleavage of substrate0.98
    		APC/C:Cdh1-mediated degradation of Skp20.74
    2M Phase
    		M Phase1.00
    		Mitotic Anaphase0.85
    		Mitotic M-M/G1 phases0.88
    		Separation of Sister Chromatids0.80
    		Mitotic Metaphase and Anaphase0.85
    3HIV Infection
    		HIV Infection1.00
    		Transcription_Ligand-Dependent Transcription of Retinoid-Target genes0.28
    		Host Interactions of HIV factors0.64
    		Transcription Ligand-Dependent Transcription of Retinoid-Target genes0.28
    4Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    		Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway1.00
    		Parkin-Ubiquitin Proteasomal System pathway0.93
    		Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    5Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Class I MHC mediated antigen processing & presentation0.83

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for PSMD11
        Immune response Antigen presentation by MHC class I
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PSMD11
        Remodeling of Adherens Junctions
    RAR-Gamma-RXR-Alpha Degradation

    3 GeneGo (Thomson Reuters) Pathways for PSMD11
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Antigen presentation by MHC class I

    2 BioSystems Pathways for PSMD11 
        Parkin-Ubiquitin Proteasomal System pathway
    Proteasome Degradation

    5/98        Reactome Pathways for PSMD11 (see all 98)
        Ubiquitinated geminin is degraded by the proteasome
    Proteolytic degradation of ubiquitinated-Cdc25A
    Orc1 removal from chromatin
    CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway


    1         Kegg Pathway  (Kegg details for PSMD11):
        Proteasome


    PSMD11 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PSMD11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/992 Interacting proteins for PSMD11 (O002312, 3 ENSP000002617124) via UniProtKB, MINT, STRING, and/or I2D (see all 992)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000084S phase of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000216M/G1 transition of mitotic cell cycle TAS--


    PSMD11 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PSMD11 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PSMD11
    Search CenterWatch for drugs/clinical trials and news about PSMD11 / PSD11 

    Transcripts
    for PSMD11 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PSMD11 gene (2 alternative transcripts): 
    NM_001270482.1  NM_002815.3  

    Unigene Cluster for PSMD11:

    Proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
    Hs.443379  [show with all ESTs]
    Unigene Representative Sequence: NM_001270482
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261712(uc002hhm.3) ENST00000578213 ENST00000457654(uc010cta.1)
    ENST00000578397(uc010wbz.1) ENST00000579451 ENST00000481992 ENST00000580904
    ENST00000584340 ENST00000493026 ENST00000469475 ENST00000585265

    miRNA
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    hsa-miR-4286 hsa-miR-548am hsa-miR-548x hsa-miR-4258
    SwitchGear 3'UTR luciferase reporter plasmid: PSMD11 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB003102.1 AF001212.1 AK290602.1 AK300342.1 BC000437.2 BC004430.1 

    22 DOTS entries:

    DT.316347  DT.101967701  DT.75100544  DT.95261630  DT.99937830  DT.100058446  DT.40118225  DT.95261640 
    DT.100674837  DT.100049290  DT.100674829  DT.100720612  DT.100058445  DT.100834185  DT.120960943  DT.120960971 
    DT.92449223  DT.92449231  DT.95261643  DT.95375200  DT.99968074  DT.120960968 

    24/556 AceView cDNA sequences (see all 556):

    AA639730 AI298594 BM839331 BM803916 AW163459 BM747626 BQ773574 BQ944078 
    BU078689 BG943120 BQ894748 BX365384 AA013152 AW206020 BU176346 AX748221 
    BQ946021 BX334992 CA843211 BQ213676 CR590971 BQ881812 BC004430 BE732040 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PSMD11    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                    -           -                                   -                                                   
    SP2:                    -           -                                   -                                                   
    SP3:                    -           -                                                                                       
    SP4:                                -                                                                                       
    SP5:                    -                                                                                                   


    ECgene alternative splicing isoforms for PSMD11

    Expression
    for PSMD11 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PSMD11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAATCTTTAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See PSMD11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PSMD11

    SOURCE GeneReport for Unigene cluster: Hs.443379

    UniProtKB/Swiss-Prot: PSD11_HUMAN, O00231
    Tissue specificity: Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate

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    In Situ
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    Orthologs
    for PSMD11 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PSMD11 gene from 9/38 species (see all 38)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PSMD111 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 less 81.38(n)
    96.35(a)    		   430878  XM_428428.3  XP_428428.3 
    lizard
    (Anolis carolinensis)    		 Reptilia PSMD116
    		 --
    		 94(a)
    		 1 ↔ 1
    		 6(65425726-65444305)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.256272 Xenopus laevis transcribed sequence with strong similarity to protein pirJC6524 (H.sapiens) JC6524 26S proteasome regulatory complex chain p44.5 - human less 81.78(n)    BJ625676.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb55b062 wufb55b06 78.98(n)   322265  BC051618.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Rpn61 , 3 proteolysis and peptidolysis proteasome
    endopeptidase less3
    Proteasome p44.5 subunit1    		 67(a)3
    63.09(n)1
    68.26(a)1    		   51C13
    366381  NM_166065.21  NP_725412.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea rpn-63
    rpn-6.11    		 Protein RPN-6.11 53(a)
    (best of 2)3
    56.15(n)1
    54.2(a)1    		   III(7031145-7033707)3
    1759721  NM_001027450.11  NP_001022621.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes RPN6(YDL097C)4
    RPN61    		 Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion less4
    Rpn6p1    		 51.31(n)1
    46.07(a)1    		   4(286695-285391)4
    8514611, 4  NP_010186.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATS91 26S proteasome regulatory subunit N6 54.76(n)
    53.1(a)    		   839789  NM_102656.3  NP_174210.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.152342 Oryza sativa (japonica cultivar-group) OsRPN6 mRNA for 26S proteasome regulatory particle non-ATPase subunit6, partial cds less 75.88(n)    AK064788.1 


    ENSEMBL Gene Tree for PSMD11 (if available)
    TreeFam Gene Tree for PSMD11 (if available) 

    Paralogs
    for PSMD11 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PSMD11 gene
    COPS22  

    PSMD11 for paralogs           About GeneDecksing



    Genomic Variants
    for PSMD11 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/583 NCBI SNPs in PSMD11 are shown (see all 583)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1386858941,2
    		--30769657(+) TCCTAA/GTCTTT 2 -- us2k10--------
    rs1427450131,2
    		--30769672(+) GTGGGG/TGTCCC 2 -- us2k10--------
    rs1843930461,2
    		--30769721(+) TTAGGA/CATCAG 2 -- us2k10--------
    rs1397552031,2
    		C,--30769785(+) GCCCC-/CTGTCAG 2 -- us2k10--------
    rs1890999381,2
    		--30769831(+) ACCCTA/GTTGTG 2 -- us2k10--------
    rs757978411,2
    		C--30769878(+) TATGAG/TAATCT 2 -- us2k10--------
    rs1810789681,2
    		--30769879(+) ATGAGA/GATCTA 2 -- us2k10--------
    rs1473897291,2
    		--30769921(+) TCCCAA/CAACCA 2 -- us2k10--------
    rs1857024251,2
    		--30770124(+) TGCCCA/GGATAA 2 -- us2k10--------
    rs732728931,2
    		C,F,--30770252(+) ACCGCG/ACCTTG 2 -- us2k13Minor allele frequency- A:0.03WA CSA 122

    HapMap Linkage Disequilibrium report for PSMD11 (30771279 - 30810336 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PSMD11: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for PSMD11 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PSMD11 for disorders           About GeneDecksing

    OMIM gene information: 604449    OMIM disorders: --

    2 diseases for PSMD11:    About MalaCards
    immunodeficiency    malaria


    Export disorders for PSMD11 gene to outside databases

    Publications
    for PSMD11 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PSMD11 gene, integrated from 9 sources (see all 78):
    (articles sorted by number of sources associating them with PSMD11)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of subunit 9 of the 26S proteasome. (PubMed id 9119060)1, 2, 3 Hoffman L. and Rechsteiner M. (1997)
    2. cDNA cloning and functional analysis of p44.5 and p55, two regulatory subunits of the 26S proteasome. (PubMed id 9426256)1, 2, 3 Saito A.... Tanaka K. (1997)
    3. Two-hybrid analysis identifies PSMD11, a non-ATPase s ubunit of the proteasome, as a novel interaction partner of AMP-activated prote in kinase. (PubMed id 19616115)1, 2, 9 Moreno D....Sanz P. (2009)
    4. Increased proteasome activity in human embryonic stem cells is regulated by PSMD11. (PubMed id 22972301)1, 2 Vilchez D.... Dillin A. (2012)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)

    External Searches for PSMD11 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing PSMD11 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5717 HGNC: 9556 AceView: PSMD11 Ensembl:ENSG00000108671 euGenes: HUgn5717
    ECgene: PSMD11 Kegg: 5717 H-InvDB: PSMD11

    Other Databases showing PSMD11 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PSMD11 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PSMD11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PSMD11 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PSMD11 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PSMD11 gene:
    Search GeneIP for patents involving PSMD11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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