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Aliases for PSMD11 Gene

Aliases for PSMD11 Gene

  • Proteasome 26S Subunit, Non-ATPase 11 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 11 2 3
  • 26S Proteasome Regulatory Subunit P44.5 3 4
  • 26S Proteasome Regulatory Subunit RPN6 3 4
  • 26S Proteasome Regulatory Subunit S9 3 4
  • 26S Proteasome Non-ATPase Regulatory Subunit 11 3
  • 26S Proteasome Regulatory Subunit 9 3
  • P44.5 3
  • Rpn6 3
  • S9 3

External Ids for PSMD11 Gene

Previous GeneCards Identifiers for PSMD11 Gene

  • GC17P030538
  • GC17P032806
  • GC17P030917
  • GC17P027795
  • GC17P030771
  • GC17P026958

Summaries for PSMD11 Gene

Entrez Gene Summary for PSMD11 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMD11 Gene

PSMD11 (Proteasome 26S Subunit, Non-ATPase 11) is a Protein Coding gene. Diseases associated with PSMD11 include Cystic Fibrosis. Among its related pathways are RET signaling and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. An important paralog of this gene is COPS2.

UniProtKB/Swiss-Prot for PSMD11 Gene

  • Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.

Gene Wiki entry for PSMD11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD11 Gene

Genomics for PSMD11 Gene

Regulatory Elements for PSMD11 Gene

Enhancers for PSMD11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G032494 1.9 FANTOM5 Ensembl ENCODE dbSUPER 24.9 +52.2 52215 4.2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 ZNF143 PSMD11 UTP6 SUZ12 TMEM98 CDK5R1 C17orf75 ENSG00000266718 ENSG00000280245
GH17G032443 1.1 ENCODE 33.7 +1.2 1214 3.3 HDGF HNRNPUL1 PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 PSMD11 UTP6 SUZ12 ENSG00000265139 CDK5R1 TMEM98 RHBDL3 C17orf75 MIR632 ZNF207
GH17G032348 1.4 ENCODE dbSUPER 19.8 -93.6 -93632 4.1 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 SUZ12 UTP6 PSMD11 LRRC37B RHBDL3 C17orf75 ZNF207 ENSG00000274341
GH17G032485 1.2 ENCODE dbSUPER 22.7 +42.5 42477 2.7 HDGF ATF1 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A ZNF766 SP5 MXD4 PSMD11 CDK5R1 ENSG00000266718
GH17G032491 1.3 Ensembl ENCODE dbSUPER 20.6 +48.1 48056 2.2 HDGF TBP WRNIP1 MAX BMI1 EBF1 ZIC2 ZBTB40 ZFHX2 EGR1 PSMD11 C17orf75 RHBDL3 ENSG00000266718 CDK5R1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSMD11 on UCSC Golden Path with GeneCards custom track

Promoters for PSMD11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000093228 639 2201 HDGF HNRNPUL1 PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for PSMD11 Gene

Chromosome:
17
Start:
32,444,261 bp from pter
End:
32,483,319 bp from pter
Size:
39,059 bases
Orientation:
Plus strand

Genomic View for PSMD11 Gene

Genes around PSMD11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD11 Gene

Proteins for PSMD11 Gene

  • Protein details for PSMD11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00231-PSD11_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 11
    Protein Accession:
    O00231
    Secondary Accessions:
    • A8K3I7
    • E1P663
    • O00495
    • Q53FT5

    Protein attributes for PSMD11 Gene

    Size:
    422 amino acids
    Molecular mass:
    47464 Da
    Quaternary structure:
    • Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD11, a base containing 6 ATPases and few additional components.

    Three dimensional structures from OCA and Proteopedia for PSMD11 Gene

    Alternative splice isoforms for PSMD11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD11 Gene

Post-translational modifications for PSMD11 Gene

  • Phosphorylated by AMPK.
  • Ubiquitination at isoforms=232, Lys71, isoforms=2141, isoforms=2175, and isoforms=2417
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMD11 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSMD11 (PSMD11)

No data available for DME Specific Peptides for PSMD11 Gene

Domains & Families for PSMD11 Gene

Gene Families for PSMD11 Gene

Suggested Antigen Peptide Sequences for PSMD11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00231

UniProtKB/Swiss-Prot:

PSD11_HUMAN :
  • Belongs to the proteasome subunit S9 family.
Family:
  • Belongs to the proteasome subunit S9 family.
genes like me logo Genes that share domains with PSMD11: view

Function for PSMD11 Gene

Molecular function for PSMD11 Gene

UniProtKB/Swiss-Prot Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
UniProtKB/Swiss-Prot Induction:
By FOXO4; expression in embryonic stem cells (ESCs) is mediated by FOXO4.

Gene Ontology (GO) - Molecular Function for PSMD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IBA --
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with PSMD11: view
genes like me logo Genes that share phenotypes with PSMD11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PSMD11

CRISPR Products

miRNA for PSMD11 Gene

miRTarBase miRNAs that target PSMD11

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD11 Gene

Localization for PSMD11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMD11 Gene

Nucleus. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMD11 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for PSMD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA,IEA 17323924
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IEA,IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PSMD11: view

Pathways & Interactions for PSMD11 Gene

SuperPathways for PSMD11 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 HIV Life Cycle
.45
4 Class I MHC mediated antigen processing and presentation
5 Antigen processing-Cross presentation
genes like me logo Genes that share pathways with PSMD11: view

Gene Ontology (GO) - Biological Process for PSMD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IMP 22972301
genes like me logo Genes that share ontologies with PSMD11: view

No data available for SIGNOR curated interactions for PSMD11 Gene

Drugs & Compounds for PSMD11 Gene

(2) Drugs for PSMD11 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 807
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMD11: view

Transcripts for PSMD11 Gene

Unigene Clusters for PSMD11 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD11 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP5: -

Relevant External Links for PSMD11 Gene

GeneLoc Exon Structure for
PSMD11
ECgene alternative splicing isoforms for
PSMD11

Expression for PSMD11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMD11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMD11 Gene

This gene is overexpressed in Breast (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMD11 Gene



Protein tissue co-expression partners for PSMD11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMD11 Gene:

PSMD11

SOURCE GeneReport for Unigene cluster for PSMD11 Gene:

Hs.443379

mRNA Expression by UniProt/SwissProt for PSMD11 Gene:

O00231-PSD11_HUMAN
Tissue specificity: Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate.

Evidence on tissue expression from TISSUES for PSMD11 Gene

  • Lung(4.6)
  • Heart(4.4)
  • Liver(4.4)
  • Pancreas(4.4)
  • Blood(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with PSMD11: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMD11 Gene

Orthologs for PSMD11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMD11 34 35
  • 99.76 (n)
cow
(Bos Taurus)
Mammalia PSMD11 34 35
  • 95.58 (n)
dog
(Canis familiaris)
Mammalia PSMD11 34 35
  • 95.58 (n)
mouse
(Mus musculus)
Mammalia Psmd11 34 16 35
  • 94.39 (n)
rat
(Rattus norvegicus)
Mammalia Psmd11 34
  • 93.56 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMD11 35
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMD11 34 35
  • 81.38 (n)
lizard
(Anolis carolinensis)
Reptilia PSMD11 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmd11 34
  • 78.83 (n)
Str.8901 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25627 34
zebrafish
(Danio rerio)
Actinopterygii psmd11a 35
  • 93 (a)
OneToMany
psmd11b 34 35
  • 78.12 (n)
wufb55b06 34
fruit fly
(Drosophila melanogaster)
Insecta Rpn6 36 34 35
  • 63.41 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001440 34
  • 62.98 (n)
worm
(Caenorhabditis elegans)
Secernentea rpn-6.1 34 35
  • 56.09 (n)
rpn-6 36
  • 53 (a)
F59B2.5 36
  • 38 (a)
rpn-6.2 35
  • 36 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR280W 34
  • 51.33 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN6 34 35 37
  • 51.31 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E01365g 34
  • 51.18 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATS9 34
  • 54.84 (n)
soybean
(Glycine max)
eudicotyledons Gma.2892 34
rice
(Oryza sativa)
Liliopsida Os04g0444600 34
  • 54.83 (n)
Os.15234 34
corn
(Zea mays)
Liliopsida Zm.6654 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1859 35
  • 68 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpn6 34
  • 55.91 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01596 34
  • 54.69 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9091 34
Species where no ortholog for PSMD11 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMD11 Gene

ENSEMBL:
Gene Tree for PSMD11 (if available)
TreeFam:
Gene Tree for PSMD11 (if available)

Paralogs for PSMD11 Gene

Paralogs for PSMD11 Gene

genes like me logo Genes that share paralogs with PSMD11: view

Variants for PSMD11 Gene

Sequence variations from dbSNP and Humsavar for PSMD11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000009688 -- 32,449,843(+) TTTTA(C/T)GCATT intron-variant
rs1000060861 -- 32,472,073(+) CTGTT(G/T)CCTAG intron-variant
rs1000075697 -- 32,465,146(+) GACAG(A/G)GTCTT intron-variant
rs1000126734 -- 32,481,333(+) CCGCC(A/G)CCGCC utr-variant-3-prime
rs1000147289 -- 32,463,086(+) GCTCT(C/T)ATGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMD11 Gene

Variant ID Type Subtype PubMed ID
nsv1131326 CNV deletion 24896259
nsv473083 CNV novel sequence insertion 20440878
nsv519839 CNV loss 19592680

Variation tolerance for PSMD11 Gene

Residual Variation Intolerance Score: 9.94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMD11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMD11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD11 Gene

Disorders for PSMD11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSMD11 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PSMD11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMD11
genes like me logo Genes that share disorders with PSMD11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMD11 Gene

Publications for PSMD11 Gene

  1. Two-hybrid analysis identifies PSMD11, a non-ATPase subunit of the proteasome, as a novel interaction partner of AMP-activated protein kinase. (PMID: 19616115) Moreno D. … Sanz P. (Int. J. Biochem. Cell Biol. 2009) 3 4 22 64
  2. Molecular cloning and expression of subunit 9 of the 26S proteasome. (PMID: 9119060) Hoffman L. … Rechsteiner M. (FEBS Lett. 1997) 2 3 4 64
  3. cDNA cloning and functional analysis of p44.5 and p55, two regulatory subunits of the 26S proteasome. (PMID: 9426256) Saito A. … Tanaka K. (Gene 1997) 2 3 4 64
  4. Increased proteasome activity in human embryonic stem cells is regulated by PSMD11. (PMID: 22972301) Vilchez D. … Dillin A. (Nature 2012) 3 4 64
  5. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X. … Huang L. (Biochemistry 2007) 3 4 64

Products for PSMD11 Gene

Sources for PSMD11 Gene