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Aliases for PSMD11 Gene

Aliases for PSMD11 Gene

  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 11 2 3
  • 26S Proteasome Regulatory Subunit P44.5 3 4
  • 26S Proteasome Regulatory Subunit RPN6 3 4
  • 26S Proteasome Regulatory Subunit S9 3 4
  • S9 3 6
  • 26S Proteasome Non-ATPase Regulatory Subunit 11 3
  • 26S Proteasome Regulatory Subunit 9 3
  • P44.5 3
  • Rpn6 3

External Ids for PSMD11 Gene

Previous GeneCards Identifiers for PSMD11 Gene

  • GC17P030538
  • GC17P032806
  • GC17P030917
  • GC17P027795
  • GC17P030771
  • GC17P026958

Summaries for PSMD11 Gene

Entrez Gene Summary for PSMD11 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMD11 Gene

PSMD11 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 11) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Downstream Signaling Events Of B Cell Receptor (BCR). An important paralog of this gene is COPS2.

UniProtKB/Swiss-Prot for PSMD11 Gene

  • Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.

Gene Wiki entry for PSMD11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD11 Gene

Genomics for PSMD11 Gene

Regulatory Elements for PSMD11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PSMD11 Gene

Start:
32,444,261 bp from pter
End:
32,483,319 bp from pter
Size:
39,059 bases
Orientation:
Plus strand

Genomic View for PSMD11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSMD11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD11 Gene

Proteins for PSMD11 Gene

  • Protein details for PSMD11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00231-PSD11_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 11
    Protein Accession:
    O00231
    Secondary Accessions:
    • A8K3I7
    • E1P663
    • O00495
    • Q53FT5

    Protein attributes for PSMD11 Gene

    Size:
    422 amino acids
    Molecular mass:
    47464 Da
    Quaternary structure:
    • Component of the lid subcomplex of the 19S proteasome regulatory particle complex (also named PA700 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

    Alternative splice isoforms for PSMD11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD11 Gene

Proteomics data for PSMD11 Gene at MOPED

Post-translational modifications for PSMD11 Gene

  • Phosphorylated by AMPK.
  • Ubiquitination at Lys32, Lys71, Lys141, Lys175, Lys274, and Lys417
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMD11 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSMD11 (PSMD11)

No data available for DME Specific Peptides for PSMD11 Gene

Domains for PSMD11 Gene

Gene Families for PSMD11 Gene

HGNC:
  • PSM :Proteasome (prosome, macropain) subunits

Suggested Antigen Peptide Sequences for PSMD11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00231

UniProtKB/Swiss-Prot:

PSD11_HUMAN :
  • O00231
Domain:
  • Contains 1 PCI domain.
Family:
  • Belongs to the proteasome subunit S9 family.
genes like me logo Genes that share domains with PSMD11: view

Function for PSMD11 Gene

Molecular function for PSMD11 Gene

UniProtKB/Swiss-Prot Function: Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
UniProtKB/Swiss-Prot Induction: By FOXO4; expression in embryonic stem cells (ESCs) is mediated by FOXO4.

Gene Ontology (GO) - Molecular Function for PSMD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with PSMD11: view
genes like me logo Genes that share phenotypes with PSMD11: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMD11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PSMD11 Gene

Localization for PSMD11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMD11 Gene

Nucleus. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMD11 Gene COMPARTMENTS Subcellular localization image for PSMD11 gene
Compartment Confidence
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for PSMD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 17323924
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005838 proteasome regulatory particle IEA --
genes like me logo Genes that share ontologies with PSMD11: view

Pathways for PSMD11 Gene

SuperPathways for PSMD11 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.38
2 Class I MHC mediated antigen processing and presentation
3 Cell Cycle, Mitotic
.62
4 Mitotic Metaphase and Anaphase
5 Downstream Signaling Events Of B Cell Receptor (BCR)
genes like me logo Genes that share pathways with PSMD11: view

Gene Ontology (GO) - Biological Process for PSMD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSMD11: view

Compounds for PSMD11 Gene

(16) ApexBio Compounds for PSMD11 Gene

Compound Action Cas Number
Aclacinomycin A Specific inhibitor of the 20S proteasome chymotrypsin-like activity [57576-44-0]
AM 114 Boronic-chalcone derived proteasome inhibitor with anticancer activity [856849-35-9]
Bortezomib (PS-341, LDP-3411) Cell-permeable proteasome inhibitor [179324-69-7]
Carfilzomib (PR-171) Proteasome inhibitor, analog of epoxomicin [868540-17-4]
CEP-18770 Orally active inhibitor of the chymotrypsin-like activity of proteasome [847499-27-8]
Dihydroeponemycin Proteasome inhibitor and antitumor reagent [126463-64-7]
Epoxomicin Irreversible proteasome inhibitor [134381-21-8]
Gliotoxin Non-competitively inhibits chymotrypsin-like activity of 20S proteasome [67-99-2]
MG-115 Reversible proteasome inhibitor
MG-132 Proteasome and calpain inhibitor. [133407-82-6]
MG-262 Boronic acid-based, reversible, cell-permeable proteasome inhibitor
MLN2238 Potent reversible and specific beta5 site of the 20S proteasome inhibitor [1072833-77-2]
MLN9708 Inhibits chymotrypsin-like proteasome activity [1201902-80-8]
ONX-0914 (PR-957) Immunoproteasome inhibitor [960374-59-8]
Oprozomib (ONX-0912) Orally bioavailable inhibitor for CT-L activity of 20S proteasome beta5/LMP7 [935888-69-0]
PSI Inhibits chymotrypsin-like proteasome activity [158442-41-2]
genes like me logo Genes that share compounds with PSMD11: view

Transcripts for PSMD11 Gene

Unigene Clusters for PSMD11 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 11:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMD11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD11 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP5: -

Relevant External Links for PSMD11 Gene

GeneLoc Exon Structure for
PSMD11
ECgene alternative splicing isoforms for
PSMD11

Expression for PSMD11 Gene

mRNA expression in normal human tissues for PSMD11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMD11 Gene

SOURCE GeneReport for Unigene cluster for PSMD11 Gene Hs.443379

mRNA Expression by UniProt/SwissProt for PSMD11 Gene

O00231-PSD11_HUMAN
Tissue specificity: Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate.
genes like me logo Genes that share expressions with PSMD11: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PSMD11 Gene

Orthologs for PSMD11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMD11 35
  • 99.76 (n)
  • 100 (a)
PSMD11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSMD11 35
  • 95.58 (n)
  • 100 (a)
PSMD11 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMD11 35
  • 95.58 (n)
  • 100 (a)
PSMD11 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmd11 35
  • 94.39 (n)
  • 99.76 (a)
Psmd11 16
Psmd11 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PSMD11 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmd11 35
  • 93.56 (n)
  • 99.71 (a)
chicken
(Gallus gallus)
Aves PSMD11 35
  • 81.38 (n)
  • 96.35 (a)
PSMD11 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMD11 36
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25627 35
tropical clawed frog
(Silurana tropicalis)
Amphibia psmd11 35
  • 78.83 (n)
  • 94.79 (a)
Str.8901 35
zebrafish
(Danio rerio)
Actinopterygii psmd11a 36
  • 93 (a)
OneToMany
psmd11b 35
  • 78.12 (n)
  • 91.23 (a)
psmd11b 36
  • 91 (a)
OneToMany
wufb55b06 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001440 35
  • 62.98 (n)
  • 68.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rpn6 35
  • 63.41 (n)
  • 68.57 (a)
Rpn6 36
  • 65 (a)
OneToOne
Rpn6 37
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea rpn-6.1 35
  • 56.09 (n)
  • 54.06 (a)
rpn-6.1 36
  • 48 (a)
OneToMany
rpn-6.2 36
  • 36 (a)
OneToMany
F59B2.5 37
  • 38 (a)
rpn-6 37
  • 53 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR280W 35
  • 51.33 (n)
  • 46.79 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN6 35
  • 51.31 (n)
  • 46.07 (a)
RPN6 36
  • 41 (a)
OneToMany
RPN6 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E01365g 35
  • 51.18 (n)
  • 47.77 (a)
soybean
(Glycine max)
eudicotyledons Gma.2892 35
thale cress
(Arabidopsis thaliana)
eudicotyledons ATS9 35
  • 54.84 (n)
  • 53.1 (a)
corn
(Zea mays)
Liliopsida Zm.6654 35
rice
(Oryza sativa)
Liliopsida Os.15234 35
Os04g0444600 35
  • 54.83 (n)
  • 52.5 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01596 35
  • 54.69 (n)
  • 52.57 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpn6 35
  • 55.91 (n)
  • 56.82 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9091 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1859 36
  • 68 (a)
OneToOne
Species with no ortholog for PSMD11:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMD11 Gene

ENSEMBL:
Gene Tree for PSMD11 (if available)
TreeFam:
Gene Tree for PSMD11 (if available)

Paralogs for PSMD11 Gene

Paralogs for PSMD11 Gene

genes like me logo Genes that share paralogs with PSMD11: view

Variants for PSMD11 Gene

Sequence variations from dbSNP and Humsavar for PSMD11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1140706 -- 32,480,978(+) aaaaa(A/G)aaaaa utr-variant-3-prime
rs1801562 -- 32,480,836(+) TTTTT(C/T)TTTTT utr-variant-3-prime
rs1803015 -- 32,479,357(+) CATTG(A/G)GCCTT reference, missense
rs1803016 -- 32,479,304(+) ACACA(C/T)TTGGC reference, synonymous-codon
rs2302276 -- 32,464,485(+) TTTTT(C/T)CCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMD11 Gene

Variant ID Type Subtype PubMed ID
nsv519839 CNV Loss 19592680

Relevant External Links for PSMD11 Gene

HapMap Linkage Disequilibrium report
PSMD11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD11 Gene

Disorders for PSMD11 Gene

No disorders were found for PSMD11 Gene.

No data available for UniProtKB/Swiss-Prot for PSMD11 Gene

Publications for PSMD11 Gene

  1. Molecular cloning and expression of subunit 9 of the 26S proteasome. (PMID: 9119060) Hoffman L. … Rechsteiner M. (FEBS Lett. 1997) 2 3 4
  2. cDNA cloning and functional analysis of p44.5 and p55, two regulatory subunits of the 26S proteasome. (PMID: 9426256) Saito A. … Tanaka K. (Gene 1997) 2 3 4
  3. Two-hybrid analysis identifies PSMD11, a non-ATPase subunit of the proteasome, as a novel interaction partner of AMP-activated protein kinase. (PMID: 19616115) Moreno D. … Sanz P. (Int. J. Biochem. Cell Biol. 2009) 3 4 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4

Products for PSMD11 Gene

Sources for PSMD11 Gene

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