Aliases for PSMD11 Gene
- Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 11 2 3
- 26S Proteasome Regulatory Subunit P44.5 3 4
- 26S Proteasome Regulatory Subunit RPN6 3 4
- 26S Proteasome Regulatory Subunit S9 3 4
- S9 3 6
- 26S Proteasome Non-ATPase Regulatory Subunit 11 3
- 26S Proteasome Regulatory Subunit 9 3
- P44.5 3
- Rpn6 3
External Ids for PSMD11 Gene
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for PSMD11 Gene
PSMD11 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 11) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Downstream Signaling Events Of B Cell Receptor (BCR). An important paralog of this gene is COPS2.
UniProtKB/Swiss-Prot for PSMD11 Gene
Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.