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Aliases for PSMD10 Gene

Aliases for PSMD10 Gene

  • Proteasome 26S Subunit, Non-ATPase 10 2 3 5
  • Gankyrin 2 3 4
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 2 3
  • 26S Proteasome Regulatory Subunit P28 3 4
  • P28(GANK) 3 4
  • Hepatocellular Carcinoma-Associated Protein P28-II 3
  • 26S Proteasome Non-ATPase Regulatory Subunit 10 3
  • Ankyrin Repeat Protein 3
  • DJ889N15.2 3
  • P28 3

External Ids for PSMD10 Gene

Previous GeneCards Identifiers for PSMD10 Gene

  • GC0XM102734
  • GC0XM104403
  • GC0XM105360
  • GC0XM106099
  • GC0XM107133
  • GC0XM107214
  • GC0XM107327
  • GC0XM096950

Summaries for PSMD10 Gene

Entrez Gene Summary for PSMD10 Gene

  • This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011]

GeneCards Summary for PSMD10 Gene

PSMD10 (Proteasome 26S Subunit, Non-ATPase 10) is a Protein Coding gene. Diseases associated with PSMD10 include Hepatocellular Carcinoma. Among its related pathways are RET signaling and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transcription factor binding. An important paralog of this gene is ANKRD2.

UniProtKB/Swiss-Prot for PSMD10 Gene

  • Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.

  • Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.

Gene Wiki entry for PSMD10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD10 Gene

Genomics for PSMD10 Gene

Regulatory Elements for PSMD10 Gene

Enhancers for PSMD10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG108307 1.2 FANTOM5 ENCODE 5.1 -217.2 -217220 3.1 ELF3 TBP FOXA2 ZSCAN4 FEZF1 BRCA1 RAD21 RFX5 YY1 GATA2 PSMD10 COL4A5 COL4A6 GC0XP108251 ENSG00000189372
GH0XG108089 1 ENCODE 0.7 +0.4 413 2.8 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 ATG4A PSMD10
GH0XG108126 1 Ensembl ENCODE 0.3 -35.4 -35357 0.4 ZBTB21 ZFP64 ZNF140 ZNF266 ZNF101 ZNF697 ZNF664 ZNF433 ZNF202 ZNF680 MID2 PSMD10 GC0XP108218
GH0XG108122 0.8 Ensembl ENCODE 0.3 -31.3 -31260 0.6 ZBTB48 BCL6B ZBTB8A TCF7L2 PSMD10 GC0XP108218
GH0XG108131 0.6 ENCODE 0.3 -40.0 -40042 0.2 JUN NR2F2 FOSL1 ARID1B CTBP1 JUND GATA3 GATA2 FOS NR2F6 PSMD10 GC0XP108218
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSMD10 on UCSC Golden Path with GeneCards custom track

Promoters for PSMD10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247882 444 2800 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143

Genomic Location for PSMD10 Gene

Chromosome:
X
Start:
108,084,205 bp from pter
End:
108,091,644 bp from pter
Size:
7,440 bases
Orientation:
Minus strand

Genomic View for PSMD10 Gene

Genes around PSMD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD10 Gene

Proteins for PSMD10 Gene

  • Protein details for PSMD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75832-PSD10_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 10
    Protein Accession:
    O75832
    Secondary Accessions:
    • Q5U0B2
    • Q8IZK9

    Protein attributes for PSMD10 Gene

    Size:
    226 amino acids
    Molecular mass:
    24428 Da
    Quaternary structure:
    • Part of transient complex containing PSMD10, PSMC4, PSMC5 and PAAF1 formed during the assembly of the 26S proteasome. Stays associated throughout the assembly of the PA700/19S RC and is released upon association with the 20S core. Interacts with PSMC4. Interacts with RB1. Interacts with CDK4. Interacts with MDM2. Interacts with RELA. Associates with a CDK4:CCND2 serine/threonine kinase complex. Interacts with ARHGDIA and increases the interaction between ARHGDIA and RHOA, hence promotes ARHGDIA inactivation of RHOA and ROCK.

    Three dimensional structures from OCA and Proteopedia for PSMD10 Gene

    Alternative splice isoforms for PSMD10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD10 Gene

Post-translational modifications for PSMD10 Gene

  • Ubiquitination at Lys23, isoforms=230, Lys90, Lys153, isoforms=213, and Lys221
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMD10 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSMD10 (PSMD10)
  • Cloud-Clone Corp. Antibodies for PSMD10

No data available for DME Specific Peptides for PSMD10 Gene

Domains & Families for PSMD10 Gene

Gene Families for PSMD10 Gene

Protein Domains for PSMD10 Gene

Suggested Antigen Peptide Sequences for PSMD10 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PSMD10: view

No data available for UniProtKB/Swiss-Prot for PSMD10 Gene

Function for PSMD10 Gene

Molecular function for PSMD10 Gene

UniProtKB/Swiss-Prot Function:
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.
UniProtKB/Swiss-Prot Function:
Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.

Gene Ontology (GO) - Molecular Function for PSMD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10613832
GO:0008134 transcription factor binding IPI 18040287
genes like me logo Genes that share ontologies with PSMD10: view
genes like me logo Genes that share phenotypes with PSMD10: view

Animal Model Products

miRNA for PSMD10 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD10 Gene

Localization for PSMD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMD10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMD10 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PSMD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA,TAS 17323924
GO:0005634 nucleus IEA,IDA 18040287
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 18040287
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMD10: view

Pathways & Interactions for PSMD10 Gene

SuperPathways for PSMD10 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 HIV Life Cycle
.45
4 Class I MHC mediated antigen processing and presentation
5 Antigen processing-Cross presentation
genes like me logo Genes that share pathways with PSMD10: view

Gene Ontology (GO) - Biological Process for PSMD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 16023600
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
genes like me logo Genes that share ontologies with PSMD10: view

No data available for SIGNOR curated interactions for PSMD10 Gene

Drugs & Compounds for PSMD10 Gene

(2) Drugs for PSMD10 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 807
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMD10: view

Transcripts for PSMD10 Gene

Unigene Clusters for PSMD10 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 10:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5: - - -
SP6:
SP7: - -

Relevant External Links for PSMD10 Gene

GeneLoc Exon Structure for
PSMD10
ECgene alternative splicing isoforms for
PSMD10

Expression for PSMD10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMD10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMD10 Gene

This gene is overexpressed in Fetal ovary (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMD10 Gene



Protein tissue co-expression partners for PSMD10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMD10 Gene:

PSMD10

SOURCE GeneReport for Unigene cluster for PSMD10 Gene:

Hs.522752

mRNA Expression by UniProt/SwissProt for PSMD10 Gene:

O75832-PSD10_HUMAN
Tissue specificity: Tends to be up-regulated in cancer cells with RAS mutations, including lung cancers and adenocarconimas (at protein level).

Evidence on tissue expression from TISSUES for PSMD10 Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with PSMD10: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMD10 Gene

Orthologs for PSMD10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PSMD10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMD10 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia PSMD10 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMD10 34 35
  • 94.1 (n)
rat
(Rattus norvegicus)
Mammalia Psmd10 34
  • 92.15 (n)
mouse
(Mus musculus)
Mammalia Psmd10 34 16 35
  • 92 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMD10 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 21 (a)
ManyToMany
chicken
(Gallus gallus)
Aves PSMD10 34 35
  • 71.53 (n)
lizard
(Anolis carolinensis)
Reptilia PSMD10 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmd10 34
  • 71.17 (n)
Str.7099 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.3178 34
zebrafish
(Danio rerio)
Actinopterygii psmd10 34 35
  • 68.44 (n)
Dr.10290 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000809 34
  • 22.06 (n)
worm
(Caenorhabditis elegans)
Secernentea F40G9.17 34 35
  • 47.62 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAS6 34 35 37
  • 46.53 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15709g 34
  • 44.73 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL142C 34
  • 43.79 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC6C3.08 34
  • 46.32 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02967 34
  • 45.9 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
OneToOne
Species where no ortholog for PSMD10 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMD10 Gene

ENSEMBL:
Gene Tree for PSMD10 (if available)
TreeFam:
Gene Tree for PSMD10 (if available)

Paralogs for PSMD10 Gene

Paralogs for PSMD10 Gene

Pseudogenes.org Pseudogenes for PSMD10 Gene

genes like me logo Genes that share paralogs with PSMD10: view

Variants for PSMD10 Gene

Sequence variations from dbSNP and Humsavar for PSMD10 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000644680 -- 108,088,478(+) TGGCT(A/C)ACTGC intron-variant, upstream-variant-2KB
rs1000939435 -- 108,092,957(+) TTTTT(A/T)ATTTT intron-variant, upstream-variant-2KB
rs1001432182 -- 108,083,961(+) AGTTC(A/G)TTAGA downstream-variant-500B
rs1002425451 -- 108,089,436(+) GTTCA(C/T)TAAAC intron-variant
rs1002472904 -- 108,089,011(+) AGACA(A/G)ATGAA intron-variant

Variation tolerance for PSMD10 Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMD10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PSMD10 Gene

Disorders for PSMD10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSMD10 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PSMD10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMD10
genes like me logo Genes that share disorders with PSMD10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMD10 Gene

Publications for PSMD10 Gene

  1. cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome. (PMID: 9714768) Hori T. … Tanaka K. (Gene 1998) 2 3 4 22 64
  2. Involvement of the mitochondrial pathway in p53-independent apoptosis induced by p28GANK knockdown in Hep3B cells. (PMID: 19729910) Wang J. … Jiao F. (Cytogenet. Genome Res. 2009) 3 4 22 64
  3. Oncoprotein p28 GANK binds to RelA and retains NF-kappaB in the cytoplasm through nuclear export. (PMID: 18040287) Chen Y. … Wang H.Y. (Cell Res. 2007) 3 4 22 64
  4. The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53. (PMID: 16023600) Higashitsuji H. … Fujita J. (Cancer Cell 2005) 3 4 22 64
  5. The crystal structure of gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53. (PMID: 14573599) Krzywda S. … Wilkinson A.J. (J. Biol. Chem. 2004) 3 4 22 64

Products for PSMD10 Gene

Sources for PSMD10 Gene

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