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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PSMD10 Gene

protein-coding   GIFtS: 64
GCID: GC0XM107327

proteasome (prosome, macropain) 26S subunit, non-ATPase,...
 Explore 15 diseases affiliated with
PSMD10 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PSMD10    

Aliases
for PSMD10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 101 2     Ankyrin Repeat Protein2
P281     DJ889N15.21
26S Proteasome Regulatory Subunit P282 3     Gankyrin3
P28(GANK)1     Hepatocellular Carcinoma-Associated Protein P28-II2
26S Proteasome Non-ATPase Regulatory Subunit 102     Gankyrin3

External Ids:    HGNC: 95551   Entrez Gene: 57162   Ensembl: ENSG000001018437   OMIM: 6034805   UniProtKB: O758323   
ORGUL members:         
NONCODE:n342244    

Export aliases for PSMD10 gene to outside databases

Previous GC identifers: GC0XM102734 GC0XM104403 GC0XM105360 GC0XM106099 GC0XM107133 GC0XM107214 GC0XM096950


Summaries
for PSMD10 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PSMD10:
This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S
proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that
may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis.
Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and
20.(provided by RefSeq, Mar 2011)

UniProtKB/Swiss-Prot: PSD10_HUMAN, O75832
Function: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory
complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1
module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates
EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays
an important role in RAS-induced tumorigenesis
Function: Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53.
Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated
phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the
mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S
proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the
cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export

Gene Wiki entry for PSMD10


Genomic Views
for PSMD10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PSMD10 gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx2-2   Nkx2-5   Nkx3-1 v1   Nkx3-1 v2   S8   COMP1   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PSMD10 promoter sequence
   Search SABiosciences Chromatin IP Primers for PSMD10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSMD10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.3   Ensembl cytogenetic band:  Xq22.3   HGNC cytogenetic band: Xq22.3

PSMD10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMD10 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM107327:  view genomic region     (about GC identifiers)

Start:
 107,327,437 bp from pter      End:
 107,334,848 bp from pter
Size:
 7,412 bases      Orientation:
 minus strand

Proteins
for PSMD10 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PSD10_HUMAN, O75832 (See protein sequence)
Recommended Name: 26S proteasome non-ATPase regulatory subunit 10  
Size: 226 amino acids; 24428 Da
Subunit: Part of transient complex containing PSMD10, PSMC4, PSMC5 and PAAF1 formed during the assembly of the 26S
proteasome. Stays associated throughout the assembly of the PA700/19S RC and is released upon association with the 20S
core. Interacts with PSMC4. Interacts with RB1. Interacts with CDK4. Interacts with MDM2. Interacts with RELA.
Associates with a CDK4:CCND2 serine/threonine kinase complex. Interacts with ARHGDIA and increases the interaction
between ARHGDIA and RHOA, hence promotes ARHGDIA inactivation of RHOA and ROCK
Subcellular location: Cytoplasm. Nucleus
Caution: Was initially identified as a genuine component of the 26S proteasome
3 PDB 3D structures from and Proteopedia for PSMD10:
1QYM (3D)        1TR4 (3D)        1UOH (3D)    
Secondary accessions: Q5U0B2 Q8IZK9
Alternative splicing: 2 isoforms:  O75832-1   O75832-2   

Explore the universe of human proteins at neXtProt for PSMD10: NX_O75832

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75832

    • PSMD10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_002805.1  NP_736606.1  

    ENSEMBL proteins: 
     ENSP00000217958   ENSP00000361370   ENSP00000361369   ENSP00000354906   ENSP00000345963  
    Reactome Protein details: O75832
    Human Recombinant Protein Products: 
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    Enzo Life Sciences proteins for PSMD10
    OriGene Purified Proteins (see all 2): PSMD10
    OriGene Protein Over-expression Lysate (see all 2): PSMD10
    OriGene Custom Protein Services for PSMD10 
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    Novus Biologicals PSMD10 Proteins
    Novus Biologicals PSMD10 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for PSMD10
    Uscn Proteins for PSMD10

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex TAS8811196
    GO:0005634nucleus IDA18040287
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--


    PSMD10 for ontologies           About GeneDecksing



    PSMD10 Antibody Products: 
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    Uscn Antibodies for PSMD10
    ThermoFisher Antibodies for PSMD10

    Assay Products for PSMD10: 
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    Uscn ELISAs and CLIAs for PSMD10

    Protein Domains /
    Families
    for PSMD10 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PSMD10 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry O75832

    ProtoNet protein and cluster: O75832

    1 Blocks protein family: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: PSD10_HUMAN, O75832
    Similarity: Contains 7 ANK repeats


    Function
    for PSMD10 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PSD10_HUMAN, O75832
    Function: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory
    complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1
    module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates
    EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays
    an important role in RAS-induced tumorigenesis
    Function: Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53.
    Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated
    phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the
    mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S
    proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the
    cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): PSMD10
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSMD10
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate PSMD10:
    hsa-miR-875-3p hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmid: PSMD10 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSMD10 (see all 7)
    OriGene shRNA RFP: PSMD10
    OriGene siRNA: PSMD10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSMD10

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PSMD10

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSMD10 (see all 5)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): PSMD10 (NM_002814)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMD10 

    Cell Line
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    Search LifeMap BioReagents cell lines for PSMD10

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMD10

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008134transcription factor binding IPI18040287


    PSMD10 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PSMD10:
     Decreased cell number and incr 


    Pathways & Interactions
    for PSMD10 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitinated Orc1 is degraded by the proteasome
    8/75 pathways (see all 75)
    		Ubiquitinated Orc1 is degraded by the proteasome1.00
    		Degradation of ubiquitinated p27/p21 by the 26S proteasome0.75
    		Proteasomal cleavage of substrate0.98
    		SCF(Skp2)-mediated degradation of p27/p210.75
    		Proteasome mediated degradation of PAK-2p340.98
    		APC/C:Cdh1-mediated degradation of Skp20.74
    		Proteasomal cleavage of substrate0.98
    		APC/C:Cdc20 mediated degradation of Securin0.74
    2M Phase
    		M Phase1.00
    		Mitotic Anaphase0.85
    		Mitotic M-M/G1 phases0.88
    		Separation of Sister Chromatids0.80
    		Mitotic Metaphase and Anaphase0.85
    3HIV Infection
    		HIV Infection1.00
    		Transcription_Ligand-Dependent Transcription of Retinoid-Target genes0.28
    		Host Interactions of HIV factors0.64
    		Transcription Ligand-Dependent Transcription of Retinoid-Target genes0.28
    4Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    		Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway1.00
    		Parkin-Ubiquitin Proteasomal System pathway0.93
    		Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    5Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Class I MHC mediated antigen processing & presentation0.83

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for PSMD10
        Immune response Antigen presentation by MHC class I
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PSMD10
        Remodeling of Adherens Junctions
    RAR-Gamma-RXR-Alpha Degradation

    3 GeneGo (Thomson Reuters) Pathways for PSMD10
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Antigen presentation by MHC class I

    2 BioSystems Pathways for PSMD10 
        Proteasome Degradation
    Parkin-Ubiquitin Proteasomal System pathway

    5/98        Reactome Pathways for PSMD10 (see all 98)
        Ubiquitinated geminin is degraded by the proteasome
    Proteolytic degradation of ubiquitinated-Cdc25A
    Orc1 removal from chromatin
    CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway



    PSMD10 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PSMD10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/188 Interacting proteins for PSMD10 (O758321, 2, 3 ENSP000002179584) via UniProtKB, MINT, STRING, and/or I2D (see all 188)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMC4P436861, 2, 3, ENSP000001578124EBI-752185,EBI-743997 MINT-7230300 I2D: score=12 STRING: ENSP00000157812
    PSMC3P179802, 3, ENSP000002988524MINT-7230300 I2D: score=7 STRING: ENSP00000298852
    PSMD12O002322, 3, ENSP000003484424MINT-7230300 I2D: score=7 STRING: ENSP00000348442
    PSMD3O432422, 3, ENSP000002646394MINT-7230300 I2D: score=7 STRING: ENSP00000264639
    PSMD7P516652, 3, ENSP000002193134MINT-7230300 I2D: score=7 STRING: ENSP00000219313
    About this table

    Gene Ontology (GO): 5/35 biological process terms (GO ID links to tree view) (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000084S phase of mitotic cell cycle TAS--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA16023600
    GO:0000209protein polyubiquitination TAS--


    PSMD10 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PSMD10 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PSMD10
    Search CenterWatch for drugs/clinical trials and news about PSMD10 / PSD10 

    Transcripts
    for PSMD10 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PSMD10 gene (2 alternative transcripts): 
    NM_002814.3  NM_170750.2  

    Unigene Cluster for PSMD10:

    Proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
    Hs.522752  [show with all ESTs]
    Unigene Representative Sequence: NM_002814
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000217958(uc004enq.2 uc004enp.2) ENST00000372296 ENST00000372295
    ENST00000361815 ENST00000340200 ENST00000553388(uc010nph.2) ENST00000338548


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSMD10
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate PSMD10:
    hsa-miR-875-3p hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmid: PSMD10 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: PSMD10
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB009619.1 AK058108.1 AK295996.1 AK309326.1 AY057056.1 BC011960.1 BT019689.1 D83197.1 

    12 DOTS entries:

    DT.319114  DT.100878410  DT.100878406  DT.121291547  DT.100794490  DT.100878411  DT.100878413  DT.121291569 
    DT.121291536  DT.91755413  DT.95144075  DT.70100561 

    24/369 AceView cDNA sequences (see all 369):

    AA210705 H25881 AA782089 BX360962 CB139745 BM547678 BU621825 AI274952 
    CF528364 BM509944 CD512371 AA495954 CD251174 CA432667 CA443603 AA831697 
    BM542172 BQ227581 AI282216 BQ285920 BC011960 NM_170750 AA810950 BM999499 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PSMD10 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d
    SP1:                                                              -     -                           
    SP2:                                                        -     -     -                           
    SP3:                                      -                       -     -                           
    SP4:                                                                                                
    SP5:                                -                             -     -                           


    ECgene alternative splicing isoforms for PSMD10

    Expression
    for PSMD10 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PSMD10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAACAAAAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PSMD10 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSpermatidGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PSMD10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PSMD10

    SOURCE GeneReport for Unigene cluster: Hs.522752

    UniProtKB/Swiss-Prot: PSD10_HUMAN, O75832
    Tissue specificity: Tends to be up-regulated in cancer cells with RAS mutations, including lung cancers and
    adenocarconimas (at protein level)

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    Orthologs
    for PSMD10 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PSMD10 gene from 9/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PSMD101 proteasome (prosome, macropain) 26S subunit, non-ATPase, more 71.53(n)
    78.32(a)    		   422351  XM_420323.3  XP_420323.3 
    lizard
    (Anolis carolinensis)    		 Reptilia PSMD106
    		 --
    		 75(a)
    		 1 ↔ 1
    		 GL343202.1(3966520-3970923)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.31782 Xenopus laevis transcribed sequence with moderate similarity more 73.55(n)    AW640557.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.102902 Danio rerio clone RK142A4G01 proteasome 26S subunit, more 76.56(n)    AY398401.1 
    mosquito
    (Anopheles gambiae)    		 Insecta AgaP_AGAP0008091 AGAP000809-PA 45.98(n)
    39.41(a)    		   1272398  XM_311348.4  XP_311348.3 
    worm
    (Caenorhabditis elegans)    		 Secernentea F40G9.176
    		 --
    		 35(a)
    		 1 ↔ 1
    		 III(194459-210062)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes NAS6(YGR232W)4
    NAS61    		 Proteasome-interacting protein involved in the assembly more4
    Nas6p1    		 46.53(n)1
    37.13(a)1    		   7(953960-954646)4
    8531471, 4  NP_011748.31  NP_011748.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G034306
    EMB5066
    (see all 3)    		 ankyrin repeat domain-containing protein EMB506
    (see all 3)    		 34(a)
    16(a)
    (see all 3)    		 1 ↔ 1
    possible ortholog
    (see all 3)    		 2(1036008-1037632)
    5(16062479-16064349)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 26S proteasome non-ATPase regulatory subunit 10, p...
    ankyrin repeat domain-containing protein, chloropl...
    (see all 3)    		 33(a)
    18(a)
    (see all 3)    		 1 ↔ 1
    possible ortholog
    (see all 3)    		 3(31347435-31351092)
    6(7120121-7122027)


    ENSEMBL Gene Tree for PSMD10 (if available)
    TreeFam Gene Tree for PSMD10 (if available) 

    Paralogs
    for PSMD10 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PSMD10 gene
    ANKRD22  ANKRD232  ANKRD12  
    18/68 SIMAP similar genes for PSMD10 using alignment to 4 protein entries:     PSD10_HUMAN (see all proteins) (see all similar genes):
    ANKDD1A    ANKS1A    PPP1R27    ANKRD23    ANKRD50    EHMT2
    ANK1    ANKRD6    ANKRD36    ANKRD36B    DKFZp434B2328    dik
    ANKK1    RIPK4    ANKRD17    ANKRD35    ASB7    DKFZp761E1322

    PSMD10 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for PSMD10
    PGOHUM00000248631 PGOHUM00000247673 PGOHUM00000238294


    Genomic Variants
    for PSMD10 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/81 NCBI SNPs in PSMD10 are shown (see all 81)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1873490891,2
    		--107327041(+) CAGTTC/TGTGTT 2 -- ds50010--------
    rs1926743171,2
    		--107327131(+) TATTTC/TGAGCA 2 -- ds50010--------
    rs1848649301,2
    		--107327153(+) ATAAAA/GTTCAA 2 -- ds50010--------
    rs1884011121,2
    		--107327390(+) GGATTC/GTAAGG 2 -- ds50010--------
    rs22354941,2
    		C,F,H,--107327546(+) CAAAAT/CAGGTA 2 -- ut31 ese37Minor allele frequency- C:0.03NS EA NA 752
    rs1915178981,2
    		--107327672(+) CAACTG/TAAAAT 2 -- ut310--------
    rs115411141,2
    		--107327705(+) TATCCA/CTCCTA 2 -- ut31 ese30--------
    rs18025281,2
    		--107327710(-) TGTGAA/TAGGAG 2 -- ut310--------
    rs1995306041,2
    		--107327738(+) TGGTT-/AAAAAA 2 -- ut310--------
    rs1467561141,2
    		--107327832(+) CCACAC/TAGAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for PSMD10 (107327437 - 107334848 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PSMD10: --
    Locus Specific Mutation Databases (LSDB): PSMD10

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    Disorders / Diseases
    for PSMD10 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PSMD10 for disorders           About GeneDecksing

    OMIM gene information: 603480    OMIM disorders: --

    15 diseases for PSMD10:    About MalaCards
    hepatocellular carcinoma    autism spectrum disorder    carcinoma    esophageal squamous cell carcinoma
    squamous cell carcinoma    retinoblastoma    oral cancer    esophagitis
    gastric cancer    colorectal cancer    osteosarcoma    hypoxia
    schizophrenia    immunodeficiency    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for PSMD10:
    Hepatocellular carcinoma

    5 Novoseek disease relationships for PSMD10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 67.7 22 10613832 (2), 16177571 (1), 18161051 (1), 12174370 (1) (see all 18)
    retinoblastoma 57.9 5 10613832 (2), 17896003 (1), 12653665 (1), 16581249 (1)
    tumors 26.8 14 17881001 (3), 17935131 (2), 16177571 (1), 18161051 (1) (see all 11)
    cirrhosis 8.87 1 12174370 (1)
    cancer 0 6 16023592 (2), 16177571 (1), 18332869 (1)


    Export disorders for PSMD10 gene to outside databases

    Publications
    for PSMD10 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PSMD10 gene, integrated from 9 sources (see all 108):
    (articles sorted by number of sources associating them with PSMD10)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome. (PubMed id 9714768)1, 2, 3, 9 Hori T.... Tanaka K. (1998)
    2. Novel insights into the INK4-CDK4/6-Rb pathway: counter action of gankyrin against INK4 proteins regulates the CDK4-mediated phosphorylation of Rb. (PubMed id 11900540)1, 2, 9 Li J. and Tsai M.D. (2002)
    3. The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53. (PubMed id 16023600)1, 2, 9 Higashitsuji H....Fujita J. (2005)
    4. Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas. (PubMed id 10613832)1, 2, 9 Higashitsuji H....Fujita J. (2000)
    5. Gankyrin is an ankyrin-repeat oncoprotein that interacts with CDK4 kinase and the S6 ATPase of the 26 S proteasome. (PubMed id 11779854)1, 2, 9 Dawson S....Mayer R.J. (2002)
    6. The crystal structure of gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53. (PubMed id 14573599)1, 2, 9 Krzywda S.... Wilkinson A.J. (2004)
    7. Solution structure of the human oncogenic protein gankyrin containing seven ankyrin repeats and analysis of its structure--function relationship. (PubMed id 15379554)1, 2, 9 Yuan C.... Tsai M.-D. (2004)
    8. Oncoprotein p28 GANK binds to RelA and retains NF-kappaB in the cytoplasm through nuclear export. (PubMed id 18040287)1, 2, 9 Chen Y....Wang H.Y. (2007)
    9. X-ray structure of human gankyrin, the product of a gene linked to hepatocellular carcinoma. (PubMed id 14997555)1, 2, 9 Manjasetty B.A....Heinemann U. (2004)
    10. Involvement of the mitochondrial pathway in p53-indep endent apoptosis induced by p28GANK knockdown in Hep3B cells. (PubMed id 19729910)1, 2, 9 Wang J....Jiao F. (2009)

    External Searches for PSMD10 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing PSMD10 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5716 HGNC: 9555 AceView: PSMD10 Ensembl:ENSG00000101843 euGenes: HUgn5716
    ECgene: PSMD10 H-InvDB: PSMD10

    Other Databases showing PSMD10 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PSMD10 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PSMD10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PSMD10 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PSMD10 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PSMD10 gene:
    Search GeneIP for patents involving PSMD10

    GeneCards and IP:
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