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PSMD10 Gene

protein-coding   GIFtS: 66
GCID: GC0XM107327

Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase,...

  See PSMD10-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 101 2     26S Proteasome Non-ATPase Regulatory Subunit 102
gankyrin1 2     Ankyrin Repeat Protein2
26S Proteasome Regulatory Subunit P282 3     dJ889N15.22
p28(GANK)2 3     Hepatocellular Carcinoma-Associated Protein P28-II2
p282 5     Gankyrin3

External Ids:    HGNC: 95551   Entrez Gene: 57162   Ensembl: ENSG000001018437   OMIM: 3008805   UniProtKB: O758323   

Export aliases for PSMD10 gene to outside databases

Previous GC identifers: GC0XM102734 GC0XM104403 GC0XM105360 GC0XM106099 GC0XM107133 GC0XM107214 GC0XM096950


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PSMD10 Gene:
This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The
26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase
subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in
tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified
on chromosomes 3 and 20.(provided by RefSeq, Mar 2011)

GeneCards Summary for PSMD10 Gene:
PSMD10 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 10) is a protein-coding gene. Diseases associated with PSMD10 include hepatocellular carcinoma. GO annotations related to this gene include transcription factor binding. An important paralog of this gene is ANKRD54.

UniProtKB/Swiss-Prot: PSD10_HUMAN, O75832
Function: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory
complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate
PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of
the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to
prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis
Function: Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and
p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates
CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2
to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the
TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of
NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its
XPO1/CRM1-mediated nuclear export

Gene Wiki entry for PSMD10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the PSMD10 gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx2-2   Nkx2-5   Nkx3-1 v1   Nkx3-1 v2   S8   COMP1   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSMD10 promoter sequence
   Search Chromatin IP Primers for PSMD10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSMD10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.3   Ensembl cytogenetic band:  Xq22.3   HGNC cytogenetic band: Xq22.3

PSMD10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMD10 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM107327:  view genomic region     (about GC identifiers)

Start:
107,327,435 bp from pter      End:
107,334,874 bp from pter
Size:
7,440 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PSD10_HUMAN, O75832 (See protein sequence)
Recommended Name: 26S proteasome non-ATPase regulatory subunit 10  
Size: 226 amino acids; 24428 Da
Subunit: Part of transient complex containing PSMD10, PSMC4, PSMC5 and PAAF1 formed during the assembly of the 26S
proteasome. Stays associated throughout the assembly of the PA700/19S RC and is released upon association with
the 20S core. Interacts with PSMC4. Interacts with RB1. Interacts with CDK4. Interacts with MDM2. Interacts with
RELA. Associates with a CDK4:CCND2 serine/threonine kinase complex. Interacts with ARHGDIA and increases the
interaction between ARHGDIA and RHOA, hence promotes ARHGDIA inactivation of RHOA and ROCK
Caution: Was initially identified as a genuine component of the 26S proteasome
3 PDB 3D structures from and Proteopedia for PSMD10:
1QYM (3D)        1TR4 (3D)        1UOH (3D)    
Secondary accessions: Q5U0B2 Q8IZK9
Alternative splicing: 2 isoforms:  O75832-1   O75832-2   

Explore the universe of human proteins at neXtProt for PSMD10: NX_O75832

Explore proteomics data for PSMD10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys23, Lys30, Lys90, Lys153, Lys213, Lys221
  • Modification sites at PhosphoSitePlus

  • See PSMD10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002805.1  NP_736606.1  

    ENSEMBL proteins: 
     ENSP00000217958   ENSP00000361370   ENSP00000361369   ENSP00000354906   ENSP00000345963  
    Reactome Protein details: O75832

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing
    PSM: Proteasome (prosome, macropain) subunits

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry O75832

    ProtoNet protein and cluster: O75832

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: PSD10_HUMAN, O75832
    Similarity: Contains 7 ANK repeats


    Find genes that share domains with PSMD10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PSD10_HUMAN, O75832
    Function: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory
    complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate
    PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of
    the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to
    prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis
    Function: Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and
    p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates
    CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2
    to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the
    TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of
    NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its
    XPO1/CRM1-mediated nuclear export

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10613832
    GO:0008134transcription factor binding IPI18040287
         
    Find genes that share ontologies with PSMD10           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PSMD10:
     Decreased cell number and incr 

    Animal Models:
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PSMD10

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    Block miRNA regulation of human, mouse, rat PSMD10 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate PSMD10:
    hsa-miR-875-3p hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidPSMD10 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): PSMD10 (NM_002814)
    Sino Biological Human cDNA Clone for PSMD10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSMD10
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    Addgene plasmids for PSMD10 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMD10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PSD10_HUMAN, O75832: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol4
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex TAS8811196
    GO:0005634nucleus IDA18040287
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with PSMD10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PSMD10 About   (see all 18)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    CDK-mediated phosphorylation and removal of Cdc60.94
    Assembly of the pre-replicative complex0.89
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    Destabilization of mRNA by AUF1 (hnRNP D0)0.88
    Ubiquitin-dependent degradation of Cyclin D10.94
    G1/S DNA Damage Checkpoints0.87
    Ubiquitin-dependent degradation of Cyclin D0.94
    CDT1 association with the CDC6-ORC-origin complex0.87
    2Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84


    Find genes that share SuperPaths with PSMD10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PSMD10
        Remodeling of Adherens Junctions
    RAR-Gamma-RXR-Alpha Degradation

    1 Cell Signaling Technology (CST) Pathway for PSMD10
        Protein Stability

    3 GeneGo (Thomson Reuters) Pathways for PSMD10
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Antigen presentation by MHC class I

    2 BioSystems Pathways for PSMD10
        Parkin-Ubiquitin Proteasomal System pathway
    Proteasome Degradation


    Selected Reactome Pathways for PSMD10 (see all 24)
        SCF(Skp2)-mediated degradation of p27/p21
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
    SCF-beta-TrCP mediated degradation of Emi1
    Ubiquitin-dependent degradation of Cyclin D1
    Orc1 removal from chromatin


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PSMD10
    Interactions:

        GeneGlobe Interaction Network for PSMD10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PSMD10 (O758321, 2, 3 ENSP000002179584) via UniProtKB, MINT, STRING, and/or I2D (see all 218)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMC4P436861, 2, 3, ENSP000001578124EBI-752185,EBI-743997 MINT-7230300 I2D: score=12 STRING: ENSP00000157812
    PSMC2P359982, 3, ENSP000002926444MINT-7230300 I2D: score=7 STRING: ENSP00000292644
    PSMC3P179802, 3, ENSP000002988524MINT-7230300 I2D: score=7 STRING: ENSP00000298852
    PSMC5P621952, 3, ENSP000003105724MINT-7230300 I2D: score=7 STRING: ENSP00000310572
    PSMD12O002322, 3, ENSP000003484424MINT-7230300 I2D: score=7 STRING: ENSP00000348442
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 32):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA16023600
    GO:0000209protein polyubiquitination TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--

    Find genes that share ontologies with PSMD10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PSMD10 (PSD10)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PSMD10 gene (2 alternative transcripts): 
    NM_002814.3  NM_170750.2  

    Unigene Cluster for PSMD10:

    Proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
    Hs.522752  [show with all ESTs]
    Unigene Representative Sequence: NM_002814
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000217958(uc004enq.2 uc004enp.2) ENST00000372296 ENST00000372295
    ENST00000361815 ENST00000340200 ENST00000553388(uc010nph.2) ENST00000338548

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    SwitchGear 3'UTR luciferase reporter plasmidPSMD10 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat PSMD10
      QuantiFast Probe-based Assays in human, mouse, rat PSMD10

    Additional mRNA sequence: 

    AB009619.1 AK058108.1 AK295996.1 AK309326.1 AY057056.1 BC011960.1 BT019689.1 D83197.1 

    12 DOTS entries:

    DT.319114  DT.100878410  DT.100878406  DT.121291547  DT.100794490  DT.100878411  DT.100878413  DT.121291569 
    DT.121291536  DT.91755413  DT.95144075  DT.70100561 

    Selected AceView cDNA sequences (see all 369):

    AI271817 BQ005422 AI222912 CA438596 CR622885 BE349136 AA495954 BI822284 
    BM509944 AW103411 AB009619 F03783 AI342460 BX090822 BM999499 NM_170750 
    F07546 CR610422 BX335424 CB250629 BC011960 AA810950 BQ285920 AI282216 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PSMD10 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d
    SP1:                                                              -     -                           
    SP2:                                                        -     -     -                           
    SP3:                                      -                       -     -                           
    SP4:                                                                                                
    SP5:                                -                             -     -                           


    ECgene alternative splicing isoforms for PSMD10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PSMD10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACAAAAAT
    PSMD10 Expression
    About this image


    PSMD10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Spermatid Seminiferous Tubules
     
     Gonad
             Spermatid Seminiferous Tubules
    PSMD10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PSMD10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522752

    UniProtKB/Swiss-Prot: PSD10_HUMAN, O75832
    Tissue specificity: Tends to be up-regulated in cancer cells with RAS mutations, including lung cancers and
    adenocarconimas (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PSMD10 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Psmd101 , 5 proteasome (prosome, macropain) 26S subunit, non-ATPase, more1, 5 92(n)1
    94.22(a)1
      X (61.67 cM)5
    533801  NM_016883.41  NP_058579.21 
     1409484295 
    chicken
    (Gallus gallus)
    Aves PSMD101 proteasome (prosome, macropain) 26S subunit, non-ATPase, more 71.53(n)
    78.32(a)
      422351  NM_001277906.1  NP_001264835.1 
    lizard
    (Anolis carolinensis)
    Reptilia PSMD106
    proteasome (prosome, macropain) 26S subunit, non-A...
    73(a)
    1 ↔ 1
    GL343202.1(3963196-3970938)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.31782 Xenopus laevis transcribed sequence with moderate similarity more 73.55(n)    AW640557.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.102902 Danio rerio clone RK142A4G01 proteasome 26S subunit, more 76.56(n)    AY398401.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0008091 AgaP_AGAP000809 22.06(n)
    3.43000000000001(a)
      1272398  XM_311348.5  XP_311348.4 
    worm
    (Caenorhabditis elegans)
    Secernentea F40G9.171 F40G9.17 47.62(n)
    41.87(a)
      13188172  NM_001267902.1  NP_001254831.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NAS6(YGR232W)4
    NAS61
    Proteasome-interacting protein involved in the assembly more4
    NAS61
    46.53(n)1
    37.13(a)1
      7(953960-954646)4
    8531471, 4  NP_011748.31  NP_011748.14 


    ENSEMBL Gene Tree for PSMD10 (if available)
    TreeFam Gene Tree for PSMD10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PSMD10 gene
    ANKRD542  ASB82  ANKRD422  ASB72  
    Selected SIMAP similar genes for PSMD10 using alignment to 4 protein entries:     PSD10_HUMAN (see all proteins) (see all similar genes):
    ANKDD1A    ANKS1A    PPP1R27    ANKRD23    ANKRD50    ANK1
    EHMT2    ANKRD6    ANKRD36    ANKRD36B    DKFZp434B2328    dik
    ANKK1    RIPK4    ANKRD17    ANKRD35    ASB7    DKFZp761E1322

    Find genes that share paralogs with PSMD10           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for PSMD10
    PGOHUM00000248631 PGOHUM00000247673 PGOHUM00000238294


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PSMD10 (see all 114)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1873490891,2
    C--107298752(+) CAGTTC/TGTGTT 2 -- ds50010--------
    rs1926743171,2
    --107298842(+) TATTTC/TGAGCA 2 -- ds50010--------
    rs1848649301,2
    --107298864(+) ATAAAA/GTTCAA 2 -- ds50010--------
    rs1884011121,2
    --107299101(+) GGATTC/GTAAGG 2 -- ds50010--------
    rs22354941,2
    C,F,H--107299257(+) CAAAAT/CAGGTA 2 -- ut31 ese37Minor allele frequency- C:0.03NS EA NA 752
    rs1915178981,2
    --107299383(+) CAACTG/TAAAAT 2 -- ut310--------
    rs115411141,2
    --107299416(+) TATCCA/CTCCTA 2 -- ut31 ese30--------
    rs1995306041,2
    --107299449(+) TGGTT-/AAAAAA 2 -- ut310--------
    rs1467561141,2
    --107299543(+) CCACAC/TAGAAA 2 -- ut310--------
    rs1404507221,2
    C--107299919(+) TTTAAC/TCTTCC 3 D G mis1 ut310--------

    HapMap Linkage Disequilibrium report for PSMD10 (107327435 - 107334874 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PSMD10: --
    Locus Specific Mutation Databases (LSDB): PSMD10

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300880    OMIM disorders: --

    1 disease for PSMD10:    
    About MalaCards
    hepatocellular carcinoma

    1 disease from the University of Copenhagen DISEASES database for PSMD10:
    Hepatocellular carcinoma

    Find genes that share disorders with PSMD10           About GenesLikeMe

    5 Novoseek inferred disease relationships for PSMD10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 67.7 22 10613832 (2), 16177571 (1), 18161051 (1), 12174370 (1) (see all 18)
    retinoblastoma 57.9 5 10613832 (2), 17896003 (1), 12653665 (1), 16581249 (1)
    tumors 26.8 14 17881001 (3), 17935131 (2), 16177571 (1), 18161051 (1) (see all 11)
    cirrhosis 8.87 1 12174370 (1)
    cancer 0 6 16023592 (2), 16177571 (1), 18332869 (1)


    Export disorders for PSMD10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PSMD10 gene, integrated from 10 sources (see all 116):
    (articles sorted by number of sources associating them with PSMD10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome. (PubMed id 9714768)1, 2, 3, 9 Hori T.... Tanaka K. (Gene 1998)
    2. Novel insights into the INK4-CDK4/6-Rb pathway: counter action of gankyrin against INK4 proteins regulates the CDK4-mediated phosphorylation of Rb. (PubMed id 11900540)1, 2, 9 Li J. and Tsai M.D. (Biochemistry 2002)
    3. The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53. (PubMed id 16023600)1, 2, 9 Higashitsuji H.... Fujita J. (Cancer Cell 2005)
    4. Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas. (PubMed id 10613832)1, 2, 9 Higashitsuji H.... Fujita J. (Nat. Med. 2000)
    5. Gankyrin is an ankyrin-repeat oncoprotein that interacts with CDK4 kinase and the S6 ATPase of the 26 S proteasome. (PubMed id 11779854)1, 2, 9 Dawson S.... Mayer R.J. (J. Biol. Chem. 2002)
    6. The crystal structure of gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53. (PubMed id 14573599)1, 2, 9 Krzywda S.... Wilkinson A.J. (J. Biol. Chem. 2004)
    7. Solution structure of the human oncogenic protein gankyrin containing seven ankyrin repeats and analysis of its structure-function relationship. (PubMed id 15379554)1, 2, 9 Yuan C.... Tsai M.-D. (Biochemistry 2004)
    8. Oncoprotein p28 GANK binds to RelA and retains NF-kappaB in the cytoplasm through nuclear export. (PubMed id 18040287)1, 2, 9 Chen Y.... Wang H.Y. (Cell Res. 2007)
    9. X-ray structure of human gankyrin, the product of a gene linked to hepatocellular carcinoma. (PubMed id 14997555)1, 2, 9 Manjasetty B.A.... Heinemann U. (Proteins 2004)
    10. Involvement of the mitochondrial pathway in p53-independent apoptosis induced by p28GANK knockdown in Hep3B cells. (PubMed id 19729910)1, 2, 9 Wang J....Jiao F. (Cytogenet. Genome Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5716 HGNC: 9555 AceView: PSMD10 Ensembl:ENSG00000101843 euGenes: HUgn5716
    ECgene: PSMD10 H-InvDB: PSMD10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PSMD10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PSMD10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PSMD10 gene:
    Search GeneIP for patents involving PSMD10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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