Search (homepage)
GeneCards Guide
Suite
- GeneALaCart
- GeneDecks
- GeneIP
- GeneNote
- GeneAnnot
- GeneLoc
- GeneTide
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
Mirror sites
User Feedback

Advanced Search (alpha)

PSMD1 Gene

protein-coding GIFtS: 60

GC02P231921

proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

User Feedback

Aliases & Descriptions
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1¹ ²		26S proteasome regulatory subunit S1² ³
S1¹ ²		proteasome 26S non-ATPase subunit 1²
Rpn2¹ ²		26S proteasome non-ATPase regulatory subunit 1²
P112¹ ²		MGC133041²
26S proteasome subunit p112² ³		MGC133040²
26S proteasome regulatory subunit RPN2² ³

External Ids:	HGNC: 9554¹	Entrez Gene: 5707²	Ensembl: ENSG00000173692⁷	UniProtKB: Q99460³

Search outside databases for aliases for PSMD1 gene

Previous GC identifers: GC02P229979 GC02P230653 GC02P231885 GC02P232124 GC02P231747 GC02P231629

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

User Feedback

Entrez Gene summary for PSMD1:

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a

20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed

of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which

contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits.

Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an

ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the

immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the

19S regulator lid, which is responsible for substrate recognition and binding. (provided by RefSeq)

UniProtKB/Swiss-Prot: PSMD1_HUMAN, Q99460

Function: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of

ubiquitinated proteins

Gene Wiki entry for PSMD1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
About This Section

User Feedback

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PSMD1 gene upstream (promoter) region

:
CREB AP-1 deltaCREB c-Fos c-Jun Sp1 NRSF form 2 NRSF form 1 STAT5A ATF

Epigenetics:

SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for PSMD1:

MePH04324-1A MePH04322-2A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q37.1

PSMD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P231921: view genomic region (about GC identifiers)

Start:	231,921,578 bp from pter
End:	232,037,541 bp from pter
Size:	115,964 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.11 NT_005403.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

User Feedback

UniProtKB/Swiss-Prot: PSMD1_HUMAN, Q99460 (See protein sequence)

Recommended Name: 26S proteasome non-ATPase regulatory subunit 1

Size: 953 amino acids; 105836 Da

Subunit: Interacts with ADRM1

Sequence caution: Sequence=AAH01053.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A

sequence; Sequence=AAH14013.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Sequence=AAH39845.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Sequence=AAH47897.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Sequence=AAH64398.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Sequence=AAH73833.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Secondary accessions: B8ZZH9 Q24JU0 Q53TI2 Q6GMU5 Q6P2P4 Q6PJM7 Q6PKG9 Q86VU1 Q8IV79

Alternative splicing: 2 isoforms: Q99460-1 Q99460-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002798.2

ENSEMBL proteins:

ENSP00000309474 ENSP00000400483 ENSP00000386932 ENSP00000406141 ENSP00000390967 ENSP00000410061

ENSP00000362738

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for PSMD1
	HuPro® and/or Recombinant Proteins from Abnova for PSMD1
	Browse Origene full length recombinant human proteins expressed in human HEK293 cells
	Novus Biologicals Protein for PSMD1
	Novus Biologicals Lysate for PSMD1
	Browse Sino Biological Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000502	proteasome complex	IEA	--
GO:0005838	proteasome regulatory particle	TAS	8816993

About this table

PSMD1 for ontologies About GeneDecksing

Antibodies for PSMD1:

	Millipore Mono- and Polyclonal Antibodies for the study of PSMD1
	Sigma-Aldrich Antibodies for PSMD1
	Browse R&D Systems for Antibodies
	Monoclonal and Polyclonal Antibodies from Abnova (PSMD1)
	Browse Origene Antibodies
	Novus Biologicals Antibodies for PSMD1
	Browse antibodies at Epitomics

Assays for PSMD1:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for PSMD1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

User Feedback

PSMD1 for domains About GeneDecksing

3 InterPro domains/families:

IPR011989 ARM-like

IPR016642 26S_Psome_Rpn2

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q99460

ProtoNet protein and cluster: Q99460

1 Blocks protein family: IPB002015 Proteasome/cyclosome

UniProtKB/Swiss-Prot: PSMD1_HUMAN, Q99460

Similarity: Belongs to the proteasome subunit S1 family

Similarity: Contains 10 PC repeats

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
About This Section

User Feedback

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PSMD1)
		Origene 29mer shRNA kits in GFP-retroviral vector: PSMD1 Origene shRNA RFP: PSMD1 Origene basic RS shRNA: PSMD1
		Applied Biosystems Silencer® siRNAs for PSMD1
		Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PSMD1 Sigma-Aldrich shRNA Panels and shRNA for PSMD1 Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		Origene GFP tagged cDNA clones in CMV expression vector: PSMD1 Origene Myc/DDK tagged cDNA clones in CMV expression vector: PSMD1 Origene untagged cDNA clones in CMV expression vector: PSMD1
		Browse Sino Biological Human cDNA Clones

UniProtKB/Swiss-Prot: PSMD1_HUMAN, Q99460

Function: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of

ubiquitinated proteins

Genatlas biochemistry entry for PSMD1:

multicatalytic proteinase complex (prosome,macropain,26S),19/22S regulator of proteasome,non ATPase subunit,p112-L

(105kDa) and p112-S (90kDa)

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005488	binding	--	--
GO:0005515	protein binding	IPI	17353931
GO:0030234	enzyme regulator activity	IEA	--

About this table

PSMD1 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
About This Section

User Feedback

PSMD1 for pathways About GeneDecksing

3 Millipore Pathways for PSMD1

	Immune response Antigen presentation by MHC class I
	Transcription Ligand-Dependent Transcription of Retinoid-Target genes
	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

1 Sigma-Aldrich "Your Favorite Gene" Pathway for PSMD1 (Your Favorite Gene powered by Ingenuity)

Protein Ubiquitination Pathway

5/22 GeneAssist Pathways for PSMD1 (see all 22 )

	Presenilin-Mediated Signaling
	CDK5 Pathway
	Ubiquitin-Proteasome Dependent Proteolysis
	ABCG and ABCA Regulation of Sterol Metabolism
	Chks in Checkpoint Regulation

1 Kegg Pathway (Kegg details for PSMD1):

hsa03050 Proteasome

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PSMD1

5/125 Interacting proteins for PSMD1 (Q99460^{1, 2} ENSP00000309474³) via UniProtKB, MINT, and/or STRING (see all 125 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PSMD6	Q15008¹^,², ENSP00000295901³	EBI-357874,EBI-359701 MINT-4050722 MINT-7230300 EBI-357874,EBI-359701 MINT-4050722 MINT-7230300 STRING: ENSP00000295901
PSMC4	P43686¹^,², ENSP00000157812³	EBI-357874,EBI-743997 MINT-4050722 MINT-7230300 EBI-357874,EBI-743997 MINT-4050722 MINT-7230300 STRING: ENSP00000157812
PSMD10	O75832¹^,², ENSP00000217958³	EBI-357874,EBI-752185 MINT-7230300 EBI-357874,EBI-752185 MINT-7230300 STRING: ENSP00000217958
PSMD4	P55036², ENSP00000357876³	MINT-3373227 MINT-4050722 STRING: ENSP00000357876
ADRM1	Q16186², ENSP00000253003³	MINT-4050722 MINT-3373536 STRING: ENSP00000253003

About this table

4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	EXP	11285280
GO:0042176	regulation of protein catabolic process	IEA	--
GO:0051436	negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle	EXP	15029244
GO:0051437	positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle	EXP	12791267

About this table

PSMD1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

User Feedback

PSMD1 for compounds About GeneDecksing

Enzo Life Sciences drugs & compounds for PSMD1

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PSMD1
8 Novoseek chemical compound relationships for PSMD1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tetranitromethane	77.02	21	8816993 (6), 16524473 (5), 11020244 (4), 8630329 (2) (see all 7)
potassium cyanide	10.25	4	11020244 (4)
phloretin	2.43	1	8408233 (1)
actinomycin d	1.40	1	17107344 (1)
etoposide	1.26	1	17107344 (1)
cycloheximide	1.26	1	17107344 (1)
dexamethasone	0.71	1	14636157 (1)
tyrosine	0.51	1	1383327 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
About This Section

User Feedback

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PSMD1)
		Applied Biosystems Silencer® siRNAs: NM_002807
		Origene 29mer shRNA kits in GFP-retroviral vector: PSMD1 Origene shRNA RFP: PSMD1 Origene basic RS shRNA: PSMD1
		Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PSMD1 Sigma-Aldrich shRNA Panels and shRNA for PSMD1 Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:

Search SABiosciences for microRNAs that regulate PSMD1:

Assays:

Applied Biosystems TaqMan® Gene Expression Assays:

NM_002807

Clones:

Origene GFP tagged cDNA clones in CMV expression vector: PSMD1
Origene Myc/DDK tagged cDNA clones in CMV expression vector: PSMD1
Origene untagged cDNA clones in CMV expression vector: PSMD1

Primers:		Origene genome-wide validated SYBR primer pairs: PSMD1
		SABiosciences RT2 qPCR Primer Assay for PSMD1: PPH07228A

REFSEQ mRNAs for PSMD1 gene:

NM_002807.2

Additional cDNA sequence:

AK307415.1 AK307513.1 AK312528.1 BC001053.2 BC007535.1 BC014013.2 BC020223.1 BC032445.1

BC039845.1 BC047897.1 BC064398.1 BC073833.1 BC094720.1 BC112344.1 BC114434.1 CR593284.1

CR620040.1 D44466.1

24/33 DOTS entries (see all 33 ):

DT.101984903 DT.448533 DT.102832678 DT.120984408 DT.97799346 DT.120984544 DT.120984410 DT.95265701

DT.100884498 DT.95265723 DT.100844567 DT.120984435 DT.456402 DT.100884507 DT.120984476 DT.92455455

DT.92455469 DT.95146966 DT.100884508 DT.120984379 DT.120984396 DT.100772258 DT.120984398 DT.120984434

24/535 AceView cDNA sequences (see all 535 ):

CD615800 T59508 AA306327 BM682240 AA253357 BE207977 AU156176 BP363171

CD656140 BC073833 AW439463 BU677807 BM977280 AA418874 BM835623 BM827976

AI420738 CR593284 BQ224859 BG941843 BM993746 CB113290 BI855915 CA434558

highest scoring ESTs for PSMD1:

D44466 AA086167 AA169719 AA189163 AA412080 AA527047 AA721412 AA903262 AI214641 AI553774

Unigene Cluster for PSMD1:

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 1

Hs.3887 [show with all ESTs]

Unigene Representative Sequence: BC094720

GeneLoc Exon Structure

12 Ensembl transcripts including schematic representations:

ENST00000308696 ENST00000431051 ENST00000409643 ENST00000440838 ENST00000444007 ENST00000488354

ENST00000491229 ENST00000447633 ENST00000467792 ENST00000477120 ENST00000481003 ENST00000373635

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
About This Section

User Feedback

PSMD1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PSMD1

¹ / ² / ³

6 probe-sets matching PSMD1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
51788_at²^{, 3}	U95-C	1	1.00	1.00	0.97	1.17	AW023096	0.60	1.00	0.82	1
1314_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.83	D44466	1.00	0.90	0.95	1
201199_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002807	0.60	1.00	0.82	1
201198_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI860431	0.60	0.75	0.68	1
201199_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201198_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

PSMD1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

About these images

CGAP SAGE TAG: TATCGTTGCC

SOURCE GeneReport for Unigene cluster: Hs.3887

Expression variation in blood from EXPOLDB for PSMD1

Primers:		Origene genome-wide validated SYBR primer pairs: PSMD1
		SABiosciences RT2 qPCR Primer Assay for PSMD1: PPH07228A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

User Feedback

Orthologs for PSMD1 gene from 5/21 species (see all 21 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	PSMD1¹	--	proteasome (prosome, macropain) 26S subunit, non-ATPase, more	99.65(n) 99.9(a)	470674 XM_526057.2 XP_526057.2
cow (Bos taurus)	PSMD1¹	--	proteasome (prosome, macropain) 26S subunit, non-ATPase, more	94.12(n) 98.95(a)	511803 XM_867844.2 XP_872937.1
rat (Rattus norvegicus)	Psmd1¹	--	proteasome (prosome, macropain) 26S subunit, non-ATPase, more	90.73(n) 98.64(a)	83806 NM_031978.1 NP_114184.1
mouse (Mus musculus)	Psmd1^{1, 5}	1⁵	proteasome (prosome, macropain) 26S subunit, non-ATPase, more^{1, 5}	91.05(n)¹ 99.06(a)¹	70247¹ NM_027357.2¹ NP_081633.1¹ AK010596⁵ AK087947⁵ (see all 28)
chicken (Gallus gallus)	PSMD1¹	--	proteasome (prosome, macropain) 26S subunit, non-ATPase, more	83(n) 97.27(a)	424926 NM_001012600.1 NP_001012618.1

About this table Species with no ortholog for PSMD1

ENSEMBL Gene Tree for PSMD1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

User Feedback

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
About This Section

User Feedback

10/114 NCBI SNPs in PSMD1 are shown (see all 114 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 143)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Related Data				Allele Frequencies
				--	--	--		--	--			--
	rs6749^1,2	C,F	232035429(+)	`TAAGGA/GCCAGA`	1	--	ut3¹		7	NA EA WA	352
	rs3754982^1,2	C,F	223763173(-)	`AAGTGC/TTTTAT`	1	--	ng5¹		7	NS EA NA WA	628
	rs1042974^1,2	H	231927338(+)	`GAGCAG/AGGGAC`	2	/R /G	mis¹ ref¹ ese³		4	NS EA	404
	rs2303351^1,2	C,F,O,A,H	223872549(-)	`AAGTTT/GACTGA`	1	--	int¹		11	EA NS NA	2038
	rs1035620^1,2	C,F,O,A,H	223850349(+)	`TTATAT/CGGGGC`	1	--	int¹		11	NS EA NA WA	688
	rs906879^1,2	C,F,O,A,H	223790236(-)	`AAAAAC/TCATTA`	1	--	int¹		19	NA EA NS WA	2668
	rs2303357^1,2	C,F,O,A,H	223792004(+)	`AGGTTA/GTGATT`	1	--	int¹		13	NS EA NA WA	840
	rs2288147^1,2	C,F,O,A,H	223779563(+)	`TTTTTG/ATGCTT`	1	--	int¹		12	EA NS NA WA	2244
--	rs6437003^1,2	C,F,A,H	223872340(+)	`AAAAAT/CCCTTT`	1	--	int¹		5	NA EA WA	218
	rs6437002^1,2	C,F,A,H	223867329(+)	`GAAGCA/GGAAAG`	1	--	int¹		108	NS EA PA EU CA WA NA	7102

About this table

HapMap Linkage Disequilibrium images for PSMD1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for PSMD1
1 CNV: 98167
3 Indels: 42264 45960 12130

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

User Feedback

PSMD1 for disorders About GeneDecksing

1 Novoseek disease relationship for PSMD1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
colon cancer	0.96	1	11020244 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

User Feedback

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

User Feedback

10/56 PubMed articles for PSMD1 gene (see all 56 ):

cDNA cloning of p112, the largest regulatory subunit of the human 26s proteasome, and functional analysis of its yeast homologue, sen3p. (PubMed id 8816993)^{1, 2, 3, 4} Yokota K.... Tanaka K. (1996)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
A novel proteasome-interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes. (PubMed id 16990800)^{3, 4} Hamazaki J....Murata S. (2006)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. (PubMed id 16097034)^{3, 4} Gevaert K.... Vandekerckhove J. (2005)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)⁴ Gauci S....Mohammed S. (2009)
Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)³ Sowa M.E....Harper J.W. (2009)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)⁴ Mayya V.... Han D.K. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

User Feedback

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

User Feedback

Entrez Gene: 5707	HGNC: 9554	AceView: PSMD1	Ensembl:ENSG00000173692	euGenes: HUgn5707
ECgene: PSMD1	Kegg: 5707	H-InvDB: PSMD1

(According to HUGE)
About This Section

User Feedback

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

User Feedback

Intellectual Property for PSMD1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

User Feedback

Patent Information for PSMD1 gene:

Search GeneIP for patents involving PSMD1

GeneCards and IP:

Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

User Feedback

Products for PSMD1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PSMD1		Antibodies for PSMD1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PSMD1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		Browse ELISAs at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PSMD1)
	Antibodies (PSMD1)
	Chimera RNAi (PSMD1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	Custom immunoassay development

Search Tocris compounds for PSMD1

	Regulatory tfbs in PSMD1 upstream (promoter) region
	Search Chromatin IP Primers for PSMD1
	DNA Methylation qPCR Primer Assays for PSMD1
	RT2 qPCR Primer Assay for PSMD1
	GNC Network for PSMD1
	Search for microRNAs that regulate PSMD1

	Assays/Drugs/Proteins for PSMD1
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for PSMD1
	Proteins for PSMD1
	Lysates for PSMD1

Browse antibodies at Epitomics

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

User Feedback

GeneCards Homepage - Last full update: 21 May 2010 - Incremental updates: 24 May 2010 , 20 Jun 2010

View Random Gene

Category			ACSF3 acyl-CoA synthetase family member 3
GIFtS Group

The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

PSMD1 gene at Home site.

hostname: server4.xennexinc.com db build: 72 index build: 72d solr: 1.4

Advanced Search (alpha)

PSMD1 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for PSMD1 gene

Summaries
for PSMD1 gene

Genomic Views
for PSMD1 gene

Proteins
for PSMD1 gene

Protein Domains/
Families
for PSMD1 gene

Gene Function
for PSMD1 gene

Pathways & Interactions
for PSMD1 gene

Drugs & Compounds
for PSMD1 gene

Transcripts
for PSMD1 gene

Expression
for PSMD1 gene

Orthologs
for PSMD1 gene

Paralogs
for PSMD1 gene

Genomic Variants
for PSMD1 gene

Disorders & Mutations
for PSMD1 gene

Medical News
for PSMD1 gene

Publications
for PSMD1 gene

Search for PSMD1 gene

Genome Databases showing PSMD1 gene

Other Databases showing PSMD1 gene

Specialized Databases showing PSMD1 gene

Intellectual Property
for PSMD1 gene

Services
for PSMD1 gene

View Random Gene

Advanced Search (alpha)

PSMD1 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor PSMD1 gene

Summariesfor PSMD1 gene

Genomic Viewsfor PSMD1 gene

Proteinsfor PSMD1 gene

Protein Domains/Familiesfor PSMD1 gene

Gene Functionfor PSMD1 gene

Pathways & Interactionsfor PSMD1 gene

Drugs & Compoundsfor PSMD1 gene

Transcriptsfor PSMD1 gene

Expression for PSMD1 gene

Orthologsfor PSMD1 gene

Paralogsfor PSMD1 gene

Genomic Variantsfor PSMD1 gene

Disorders & Mutationsfor PSMD1 gene

Medical Newsfor PSMD1 gene

Publicationsfor PSMD1 gene

Search for PSMD1 gene

Genome Databases showing PSMD1 gene

Other Databases showing PSMD1 gene

Specialized Databases showing PSMD1 gene

Intellectual Propertyfor PSMD1 gene

Servicesfor PSMD1 gene

View Random Gene

Aliases &
Descriptions
for PSMD1 gene

Summaries
for PSMD1 gene

Genomic Views
for PSMD1 gene

Proteins
for PSMD1 gene

Protein Domains/
Families
for PSMD1 gene

Gene Function
for PSMD1 gene

Pathways & Interactions
for PSMD1 gene

Drugs & Compounds
for PSMD1 gene

Transcripts
for PSMD1 gene

Expression
for PSMD1 gene

Orthologs
for PSMD1 gene

Paralogs
for PSMD1 gene

Genomic Variants
for PSMD1 gene

Disorders & Mutations
for PSMD1 gene

Medical News
for PSMD1 gene

Publications
for PSMD1 gene

Intellectual Property
for PSMD1 gene

Services
for PSMD1 gene