Aliases for PSMD1 Gene
Previous GeneCards Identifiers for PSMD1 Gene
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2010]
GeneCards Summary for PSMD1 Gene
PSMD1 (Proteasome 26S Subunit, Non-ATPase 1) is a Protein Coding gene. Among its related pathways are Epstein-Barr virus infection and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include binding and enzyme regulator activity.
UniProtKB/Swiss-Prot for PSMD1 Gene
Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.