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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PSMD1 Gene

protein-coding GIFtS: 64
GCID: GC02P231921

proteasome (prosome, macropain) 26S subunit, non-ATPase,...

Explore 7 diseases affiliated with
PSMD1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 1¹ ²		26S Proteasome Regulatory Subunit RPN2² ³
P112¹ ²		26S Proteasome Regulatory Subunit S1² ³
Rpn2¹ ²		26S Proteasome Subunit P112² ³
S1¹ ²		26S Proteasome Non-ATPase Regulatory Subunit 1²

External Ids:	HGNC: 9554¹	Entrez Gene: 5707²	Ensembl: ENSG00000173692⁷	UniProtKB: Q99460³

ORGUL members:
	NONCODE:n409659

Export aliases for PSMD1 gene to outside databases

Previous GC identifers: GC02P229979 GC02P230653 GC02P231885 GC02P232124 GC02P231747 GC02P231629 GC02P223763

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PSMD1:

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a

20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed

of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which

contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits.

Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an

ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the

immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the

19S regulator lid, which is responsible for substrate recognition and binding. Alternatively spliced transcript

variants have been found for this gene.(provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: PSMD1_HUMAN, Q99460

Function: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of

ubiquitinated proteins

Gene Wiki entry for PSMD1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PSMD1 gene promoter:
CREB AP-1 deltaCREB ATF-2 MIF-1 c-Jun AP-2gamma
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PSMD1 promoter sequence

Search SABiosciences Chromatin IP Primers for PSMD1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSMD1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q37.1

PSMD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMD1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P231921: view genomic region (about GC identifiers)

Start:	231,921,578 bp from pter	End:	232,037,541 bp from pter
Size:	115,964 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PSMD1_HUMAN, Q99460 (See protein sequence)

Recommended Name: 26S proteasome non-ATPase regulatory subunit 1

Size: 953 amino acids; 105836 Da

Subunit: Interacts with ADRM1

Sequence caution: Sequence=AAH01053.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A

sequence; Sequence=AAH14013.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Sequence=AAH39845.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Sequence=AAH47897.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Sequence=AAH64398.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Sequence=AAH73833.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Secondary accessions: B8ZZH9 Q24JU0 Q53TI2 Q6GMU5 Q6P2P4 Q6PJM7 Q6PKG9 Q86VU1 Q8IV79

Alternative splicing: 2 isoforms: Q99460-1 Q99460-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PSMD1: NX_Q99460

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99460

PSMD1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001177966.1 NP_002798.2

ENSEMBL proteins:

ENSP00000309474 ENSP00000400483 ENSP00000406141 ENSP00000386932 ENSP00000390967

ENSP00000410061 ENSP00000362738

Reactome Protein details: Q99460
Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
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	Uscn Proteins for PSMD1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000502	proteasome complex	TAS	8811196
GO:0005654	nucleoplasm	TAS	--
GO:0005829	cytosol	TAS	--
GO:0005838	proteasome regulatory particle	TAS	8816993
GO:0022624	proteasome accessory complex	ISS	--

PSMD1 for ontologies About GeneDecksing

PSMD1 Antibody Products:

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	Novus Biologicals PSMD1 Antibodies
	Search for Antibodies for PSMD1 at Abcam
	Uscn Antibodies for PSMD1
	ThermoFisher Antibody for PSMD1

Assay Products for PSMD1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PSMD1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PSMD1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PSMD1 for domains About GeneDecksing

4 InterPro domains/families:

IPR011989 ARM-like

IPR016642 26S_Psome_Rpn2

IPR002015 APC_proteasome

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q99460

ProtoNet protein and cluster: Q99460

1 Blocks protein family: IPB002015 Proteasome/cyclosome

UniProtKB/Swiss-Prot: PSMD1_HUMAN, Q99460

Similarity: Belongs to the proteasome subunit S1 family

Similarity: Contains 10 PC repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PSMD1_HUMAN, Q99460

Function: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of

ubiquitinated proteins

Genatlas biochemistry entry for PSMD1:

multicatalytic proteinase complex (prosome,macropain,26S),19/22S regulator of proteasome,non ATPase subunit,p112-L

(105kDa) and p112-S (90kDa)

miRNA Products:		OriGene 3'-UTR Clone: PSMD1 Browse MicroRNA Expression Plasmids
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		2 QIAGEN miScript miRNA Assays for microRNAs that regulate PSMD1:
		hsa-miR-548aa hsa-miR-570
		SwitchGear 3'UTR luciferase reporter plasmid: PSMD1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PSMD1

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		GenScript: all cDNA clones in your preferred vector (see all 2): PSMD1 (NM_002807)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PSMD1
		Search LifeMap BioReagents cell lines for PSMD1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMD1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030234	enzyme regulator activity	IEA	--

PSMD1 for ontologies About GeneDecksing

6 GenomeRNAi human phenotypes for PSMD1:

Decreased Hepatitis C virus re	Decreased homologous recombina	Decreased viability	Decreased viability of wild-ty
Decreased viability with pacli	Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/29 super-pathways (see all 29) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/78 pathways (see all 78)
Ubiquitinated Orc1 is degraded by the proteasome	1.00	Degradation of ubiquitinated p27/p21 by the 26S proteasome	0.75
Proteasomal cleavage of substrate	0.98	SCF(Skp2)-mediated degradation of p27/p21	0.75
Proteasome mediated degradation of PAK-2p34	0.98	APC/C:Cdh1-mediated degradation of Skp2	0.74
Proteasomal cleavage of substrate	0.98	APC/C:Cdc20 mediated degradation of Securin	0.74

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Chks in Checkpoint Regulation

Chks in Checkpoint Regulation	1.00	p53 Signaling	0.32
G2-M Phase Transition	0.59	DNA Repair Mechanisms	0.32
Estrogen-mediated S-Phase Entry	0.55

HIV Infection

	HIV Infection	1.00			Transcription_Ligand-Dependent Transcription of Retinoid-Target genes	0.28
	Host Interactions of HIV factors	0.64			Transcription Ligand-Dependent Transcription of Retinoid-Target genes	0.28

Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway	1.00			Parkin-Ubiquitin Proteasomal System pathway	0.93
	Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway	0.93

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for PSMD1

	Immune response Antigen presentation by MHC class I
	Transcription Ligand-Dependent Transcription of Retinoid-Target genes
	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

5/19 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PSMD1 (see all 19)

	Remodeling of Adherens Junctions
	CDK5 Pathway
	Estrogen-mediated S-Phase Entry
	G2-M Phase Transition
	DNA Repair Mechanisms

3 GeneGo (Thomson Reuters) Pathways for PSMD1

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Transcription Ligand-Dependent Transcription of Retinoid-Target genes
	Immune response Antigen presentation by MHC class I

3 BioSystems Pathways for PSMD1

	TNF-alpha/NF-kB Signaling Pathway
	Proteasome Degradation
	Parkin-Ubiquitin Proteasomal System pathway

5/98 Reactome Pathways for PSMD1 (see all 98)

	Ubiquitinated geminin is degraded by the proteasome
	Proteolytic degradation of ubiquitinated-Cdc25A
	Orc1 removal from chromatin
	CDK-mediated phosphorylation and removal of Cdc6
	ER-Phagosome pathway

1 Kegg Pathway (Kegg details for PSMD1):

Proteasome

PSMD1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PSMD1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/943 Interacting proteins for PSMD1 (Q99460^{2, 3} ENSP00000309474⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 943)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PSMC5	P62195²^,³, ENSP00000310572⁴	MINT-4050722 MINT-7945693 MINT-7230300 MINT-7947479 I2D: score=6 STRING: ENSP00000310572
PSMC4	P43686²^,³, ENSP00000157812⁴	MINT-4050722 MINT-7945693 MINT-7230300 MINT-7947479 I2D: score=5 STRING: ENSP00000157812
PSMC1	P62191²^,³, ENSP00000261303⁴	MINT-4050722 MINT-7945693 MINT-7230300 MINT-7947479 I2D: score=4 STRING: ENSP00000261303
PSMD12	O00232²^,³, ENSP00000348442⁴	MINT-4050722 MINT-7945693 MINT-7230300 MINT-7947479 I2D: score=4 STRING: ENSP00000348442
PSMD13	Q9UNM6²^,³, ENSP00000396937⁴	MINT-4050722 MINT-7945693 MINT-7947479 I2D: score=6 STRING: ENSP00000396937

About this table

Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000084	S phase of mitotic cell cycle	TAS	--
GO:0000209	protein polyubiquitination	TAS	--
GO:0000216	M/G1 transition of mitotic cell cycle	TAS	--

PSMD1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PSMD1

1 DrugBank Compound for PSMD1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Bortezomib	--	179324-69-7	target	inhibitor	20954323 17139284 17016423

Search CenterWatch for drugs/clinical trials and news about PSMD1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PSMD1 gene (2 alternative transcripts):

NM_001191037.1 NM_002807.3

Unigene Cluster for PSMD1:

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 1

Hs.3887 [show with all ESTs]

Unigene Representative Sequence: NM_002807

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000308696(uc002vrn.2 uc002vrm.2 uc010fxu.2) ENST00000431051

ENST00000440838 ENST00000409643 ENST00000444007 ENST00000447633 ENST00000488354

ENST00000467792 ENST00000477120 ENST00000481003 ENST00000491229 ENST00000373635

miRNA Products:		OriGene 3'-UTR Clone: PSMD1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSMD1
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate PSMD1:
		hsa-miR-548aa hsa-miR-570
		SwitchGear 3'UTR luciferase reporter plasmid: PSMD1 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSMD1

Additional cDNA sequence:

AK307415.1 AK312528.1 BC001053.2 BC007535.1 BC014013.2 BC020223.1 BC032445.1 BC039845.1

BC047897.1 BC064398.1 BC073833.1 BC094720.1 BC112344.1 BC114434.1 D44466.1 NR_034059.1

24/32 DOTS entries (see all 32):

DT.101984903 DT.448533 DT.102832678 DT.120984408 DT.97799346 DT.120984544 DT.120984410 DT.95265701

DT.100884498 DT.95265723 DT.100844567 DT.120984435 DT.456402 DT.100884507 DT.120984476 DT.92455469

DT.95146966 DT.100884508 DT.120984379 DT.120984396 DT.92455455 DT.100772258 DT.120984398 DT.120984434

24/535 AceView cDNA sequences (see all 535):

BQ435298 AI149236 CA434558 CF129255 BI855915 BU838964 BM795226 AU131216

AU131438 BQ008378 BP363171 BQ224859 BG941843 BU682007 BM993746 AL135218

CA440723 BC014013 BU500882 BQ218829 AU121768 BQ955201 BP346184 BC064398

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PSMD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATCGTTGCC

About this image

PSMD1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PSMD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PSMD1

SOURCE GeneReport for Unigene cluster: Hs.3887

SABiosciences Custom PCR Arrays for PSMD1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSMD1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSMD1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSMD1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMD1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD1 gene from 9/36 species (see all 36) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PSMD1¹	proteasome (prosome, macropain) 26S subunit, non-ATPase, more	83(n) 97.27(a)		424926 NM_001012600.1 NP_001012618.1
lizard (Anolis carolinensis)	Reptilia	PSMD1⁶	--	95(a)	1 ↔ 1	GL343433.1(490355-621363)
African clawed frog (Xenopus laevis)	Amphibia	CB201011.2²	--	79.49(n)		CB201011.2
zebrafish (Danio rerio)	Actinopterygii	zgc55818²	similar to proteasome (prosome, macropain) 26S subunit, more	79.55(n)		394159 BC045463.1
fruit fly (Drosophila melanogaster)	Insecta	Rpn2^{1 , 3}	proteolysis and peptidolysis proteasome endopeptidase³ CG11888-PA¹	65(a)³ 61.05(n)¹ 66.81(a)¹		98F13³ 43449¹ NM_143420.2¹ NP_651677.2¹
worm (Caenorhabditis elegans)	Secernentea	rpn-2⁶	26S proteasome non-ATPase regulatory subunit 1	34(a)	1 ↔ 1	III(6198850-6202575)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RPN2(YIL075C)⁴ RPN2¹	Subunit of the 26S proteasome, substrate of the N-acetyltransferase more⁴ Rpn2p¹	51.84(n)¹ 45.6(a)¹		9(220700-217863)⁴ 854735^{1, 4} NP_012190.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G04810¹	26S proteasome regulatory subunit N2	55.47(n) 52.39(a)		839409 NM_100359.2 NP_171973.1
rice (Oryza sativa)	Liliopsida	Os.15239²	Oryza sativa (japonica cultivar-group) OsRPN2a mRNA more	72.53(n)		AK121754.1

ENSEMBL Gene Tree for PSMD1 (if available)
TreeFam Gene Tree for PSMD1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148578790^1,2	C,F	other	232028424(+)	`CAAAAG/AAAAAA`	4	/K /E	mis¹ int¹		1		NA	4270
rs35057221^1,2	C	--	223770607(+)	`ATGGA-/TTTTTT`	1	--	int¹		2		NA CSA	4
rs34818750^1,2	C	--	223848195(+)	`TATAC-/TTTTTT`	1	--	int¹		1		NA	2
rs189882667^1,2		--	231919720(+)	`TCAAGC/TGATTC`	3	--	us2k¹		0	--	--	--	--
rs142563785^1,2		--	231919914(+)	`CGCCCA/GGCCAG`	3	--	us2k¹		0	--	--	--	--
rs111969641^1,2		--	231919947(+)	`CCCACG/CACCCC`	3	--	us2k¹		1		CSA	2
rs145886064^1,2		--	231920176(+)	`GAGGCC/TGAGGC`	3	--	us2k¹		0	--	--	--	--
rs112781409^1,2		--	231920207(+)	`AGATCA/GAGACC`	3	--	us2k¹		1		CSA	1
rs181111234^1,2		--	231920312(+)	`ACTGAA/GCAGGA`	3	--	us2k¹		0	--	--	--	--
rs184673951^1,2		--	231920387(+)	`TGGGTA/GGCAGA`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PSMD1 (231921578 - 232037541 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for PSMD1
1 CNV: 98167
3 Indels: 42264 45960 12130

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PSMD1 for disorders About GeneDecksing

7 diseases for PSMD1: About MalaCards

pyloric stenosis neuroblastoma immunodeficiency malaria

neuronitis huntington's disease parkinson's disease

Human Genome Epidemiology (HuGE) Navigator: PSMD1 (4 documents)

Export disorders for PSMD1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PSMD1 gene, integrated from 9 sources (see all 109):
(articles sorted by number of sources associating them with PSMD1)

Utopia: connect your pdf to the dynamic
world of online information

cDNA cloning of p112, the largest regulatory subunit of the human 26s proteasome, and functional analysis of its yeast homologue, sen3p. (PubMed id 8816993)^{1, 2, 3, 9} Yokota K.... Tanaka K. (1996)
A novel proteasome-interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes. (PubMed id 16990800)^{1, 2} Hamazaki J....Murata S. (2006)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)¹ Lin Y.Y....Boeke J.D. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5707	HGNC: 9554	AceView: PSMD1	Ensembl:ENSG00000173692	euGenes: HUgn5707
ECgene: PSMD1	Kegg: 5707	H-InvDB: PSMD1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PSMD1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PSMD1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PSMD1 gene:
Search GeneIP for patents involving PSMD1

GeneCards and IP:
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