Aliases for PSMC6 Gene
External Ids for PSMC6 Gene
Previous GeneCards Identifiers for PSMC6 Gene
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSMC6 Gene
PSMC6 (Proteasome 26S Subunit, ATPase 6) is a Protein Coding gene. Diseases associated with PSMC6 include Phaeochromocytoma. Among its related pathways are Cell Cycle Checkpoints and Mitotic Metaphase and Anaphase. GO annotations related to this gene include hydrolase activity and protein binding, bridging.
UniProtKB/Swiss-Prot for PSMC6 Gene
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.