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Aliases for PSMC6 Gene

Aliases for PSMC6 Gene

  • Proteasome 26S Subunit, ATPase 6 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 6 2 3
  • 26S Proteasome AAA-ATPase Subunit RPT4 3 4
  • Proteasome Subunit P42 3 4
  • SUG2 3 4
  • 26S Protease Regulatory Subunit S10B 3
  • 26S Protease Regulatory Subunit 10B 3
  • Conserved ATPase Domain Protein 44 3
  • Epididymis Secretory Protein Li 73 3
  • Proteasome 26S Subunit ATPase 6 4
  • HEL-S-73 3
  • CADP44 3
  • P42 3
  • P44 3

External Ids for PSMC6 Gene

Previous GeneCards Identifiers for PSMC6 Gene

  • GC14P050496
  • GC14P046969
  • GC14P051163
  • GC14P052243
  • GC14P053173
  • GC14P033334

Summaries for PSMC6 Gene

Entrez Gene Summary for PSMC6 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMC6 Gene

PSMC6 (Proteasome 26S Subunit, ATPase 6) is a Protein Coding gene. Among its related pathways are RET signaling and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include hydrolase activity and protein binding, bridging.

UniProtKB/Swiss-Prot for PSMC6 Gene

  • The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

Gene Wiki entry for PSMC6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMC6 Gene

Genomics for PSMC6 Gene

Regulatory Elements for PSMC6 Gene

Enhancers for PSMC6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F052706 0.2 ENCODE 13 +0.2 162 2.4 PKNOX1 SIN3A DMAP1 ZNF48 ETS1 YY1 ELK1 GATA2 ZNF143 DEK STYX LOC105370500 PSMC6
GH14F052740 0.9 Ensembl ENCODE 11.3 +35.2 35238 3.6 PKNOX1 PBX2 CEBPB MLLT1 ZBTB33 ZBTB40 SPI1 YY1 STYX PSMC6 ERO1A ENSG00000259049
GH14F052736 0.2 Ensembl 10.7 +29.0 29038 0.4 GLIS1 PSMC6 ERO1A STYX ENSG00000259049
GH14F051979 1 Ensembl ENCODE 9.8 -727.9 -727863 0.6 GTF2F1 CTCF TEAD4 RAD21 RFX5 ZNF791 ZNF143 SMC3 PRDM10 RCOR1 LOC105370500 PSMC6 TMX1 ENSG00000259007 LOC105370497
GH14F052702 1.2 Ensembl ENCODE 0.8 -3.7 -3654 1.3 TBP MAX CEBPB EP300 ATF2 JUND CEBPA STAT3 FOS STYX PSMC6 ERO1A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PSMC6 on UCSC Golden Path with GeneCards custom track

Promoters for PSMC6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000417791 537 2201 PKNOX1 SIN3A DMAP1 ZNF48 ETS1 YY1 ELK1 GATA2 ZNF143 DEK

Genomic Location for PSMC6 Gene

Chromosome:
14
Start:
52,707,163 bp from pter
End:
52,728,587 bp from pter
Size:
21,425 bases
Orientation:
Plus strand

Genomic View for PSMC6 Gene

Genes around PSMC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMC6 Gene

Proteins for PSMC6 Gene

  • Protein details for PSMC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62333-PRS10_HUMAN
    Recommended name:
    26S protease regulatory subunit 10B
    Protein Accession:
    P62333
    Secondary Accessions:
    • B2R975
    • P49719
    • Q6IBU3
    • Q92524

    Protein attributes for PSMC6 Gene

    Size:
    389 amino acids
    Molecular mass:
    44173 Da
    Quaternary structure:
    • Found in the multi-protein complexes: the 26S proteasome (formed from the 20S proteasome and PA700), and the modulator. PA700 consists of 28 subunits arranged to form a cylinder-shaped complex by four stacked rings, each containing seven subunits. Interacts with PAAF1.

    Three dimensional structures from OCA and Proteopedia for PSMC6 Gene

neXtProt entry for PSMC6 Gene

Post-translational modifications for PSMC6 Gene

  • Ubiquitination at Lys 7, Lys 20, Lys 48, Lys 168, Lys 180, Lys 197, Lys 274, Lys 298, Lys 314, Lys 322, Lys 333, and Lys 369
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for PSMC6
  • Santa Cruz Biotechnology (SCBT) Antibodies for PSMC6

No data available for DME Specific Peptides for PSMC6 Gene

Domains & Families for PSMC6 Gene

Gene Families for PSMC6 Gene

Suggested Antigen Peptide Sequences for PSMC6 Gene

Graphical View of Domain Structure for InterPro Entry

P62333

UniProtKB/Swiss-Prot:

PRS10_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with PSMC6: view

Function for PSMC6 Gene

Molecular function for PSMC6 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (prosome,macropain,26kDa) 19/22S regulator of proteasome p42,ATPase subunit,44kDa
UniProtKB/Swiss-Prot Function:
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

Gene Ontology (GO) - Molecular Function for PSMC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0016887 ATPase activity TAS 9464850
genes like me logo Genes that share ontologies with PSMC6: view
genes like me logo Genes that share phenotypes with PSMC6: view

Animal Model Products

miRNA for PSMC6 Gene

miRTarBase miRNAs that target PSMC6

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMC6 Gene

Localization for PSMC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMC6 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMC6 Gene COMPARTMENTS Subcellular localization image for PSMC6 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 3
cytoskeleton 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for PSMC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA,IDA 9464850
GO:0005634 nucleus IEA,IDA 10419517
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMC6: view

Pathways & Interactions for PSMC6 Gene

SuperPathways for PSMC6 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
.78
.32
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMC6: view

Gene Ontology (GO) - Biological Process for PSMC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IC 9464850
genes like me logo Genes that share ontologies with PSMC6: view

No data available for SIGNOR curated interactions for PSMC6 Gene

Drugs & Compounds for PSMC6 Gene

(21) Drugs for PSMC6 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 794
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0

(9) Additional Compounds for PSMC6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PSMC6: view

Transcripts for PSMC6 Gene

Unigene Clusters for PSMC6 Gene

Proteasome (prosome, macropain) 26S subunit, ATPase, 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMC6 Gene

No ASD Table

Relevant External Links for PSMC6 Gene

GeneLoc Exon Structure for
PSMC6
ECgene alternative splicing isoforms for
PSMC6

Expression for PSMC6 Gene

mRNA expression in normal human tissues for PSMC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMC6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMC6 Gene



Protein tissue co-expression partners for PSMC6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMC6 Gene:

PSMC6

SOURCE GeneReport for Unigene cluster for PSMC6 Gene:

Hs.156171
genes like me logo Genes that share expression patterns with PSMC6: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMC6 Gene

Orthologs for PSMC6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMC6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMC6 34 35
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMC6 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMC6 34 35
  • 96.44 (n)
cow
(Bos Taurus)
Mammalia PSMC6 34 35
  • 95.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PSMC6 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmc6 34 16 35
  • 93.14 (n)
rat
(Rattus norvegicus)
Mammalia Psmc6 34
  • 92.89 (n)
chicken
(Gallus gallus)
Aves PSMC6 34 35
  • 85.09 (n)
lizard
(Anolis carolinensis)
Reptilia PSMC6 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmc6 34
  • 83.2 (n)
MGC76159 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.3381 34
zebrafish
(Danio rerio)
Actinopterygii psmc6 34 35
  • 78.75 (n)
Dr.29047 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8441 34
fruit fly
(Drosophila melanogaster)
Insecta CG7257 36
  • 81 (a)
Rpt4R 35
  • 80 (a)
OneToMany
Rpt4 36 34 35
  • 70.22 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001407 34
  • 69.44 (n)
worm
(Caenorhabditis elegans)
Secernentea rpt-4 34 35
  • 67.86 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPT4 34 35
  • 64.4 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C09592g 34
  • 62.23 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL113W 34
  • 61.9 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RPT4A 34
  • 69.55 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5748 34
rice
(Oryza sativa)
Liliopsida Os02g0199900 34
  • 68.74 (n)
Os.292 34
barley
(Hordeum vulgare)
Liliopsida Hv.5889 34
wheat
(Triticum aestivum)
Liliopsida Ta.14349 34
corn
(Zea mays)
Liliopsida Zm.3972 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3434 35
  • 90 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpt4 34
  • 63.79 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07367 34
  • 61.84 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11771 34
Species where no ortholog for PSMC6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMC6 Gene

ENSEMBL:
Gene Tree for PSMC6 (if available)
TreeFam:
Gene Tree for PSMC6 (if available)

Paralogs for PSMC6 Gene

No data available for Paralogs for PSMC6 Gene

Variants for PSMC6 Gene

Sequence variations from dbSNP and Humsavar for PSMC6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10130265 -- 52,723,687(+) CATGT(A/G)CATAG intron-variant
rs10136643 -- 52,725,749(+) GGCCC(A/G)AGTAA intron-variant
rs10140532 -- 52,727,231(+) tcacc(A/G)tgttg intron-variant
rs10144318 -- 52,723,013(+) GTTGA(A/C)TTTCA intron-variant
rs10145038 -- 52,705,470(+) CTCAT(G/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PSMC6 Gene

Variant ID Type Subtype PubMed ID
esv2090227 CNV deletion 18987734
nsv832796 CNV loss 17160897
nsv983825 CNV duplication 23825009

Variation tolerance for PSMC6 Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMC6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMC6 Gene

Disorders for PSMC6 Gene

Relevant External Links for PSMC6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMC6

No disorders were found for PSMC6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMC6 Gene

Publications for PSMC6 Gene

  1. Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N. … Tanaka K. (Biochem. Biophys. Res. Commun. 1998) 2 3 22 64
  2. cDNA cloning of p42, a shared subunit of two proteasome regulatory proteins, reveals a novel member of the AAA protein family. (PMID: 8674546) Fujiwara T. … Demartino G.N. (FEBS Lett. 1996) 2 3 4 64
  3. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X. … Huang L. (Biochemistry 2007) 3 4 64
  4. Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. (PMID: 15831487) Park Y. … Yoon J.-B. (Mol. Cell. Biol. 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for PSMC6 Gene

Sources for PSMC6 Gene

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