Aliases for PSMC6 Gene
Aliases for PSMC6 Gene
External Ids for PSMC6 Gene
- HGNC: 9553
- Entrez Gene: 5706
- Ensembl: ENSG00000100519
- OMIM: 602708
- UniProtKB: P62333
Previous GeneCards Identifiers for PSMC6 Gene
- GC14P050496
- GC14P046969
- GC14P051163
- GC14P052243
- GC14P053173
- GC14P033334
Summaries for PSMC6 Gene
-
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSMC6 Gene
PSMC6 (Proteasome 26S Subunit, ATPase 6) is a Protein Coding gene. Among its related pathways are RET signaling and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include hydrolase activity and protein binding, bridging.
UniProtKB/Swiss-Prot for PSMC6 Gene
-
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMC6 Gene
Genomics for PSMC6 Gene
Regulatory Elements for PSMC6 Gene
Enhancers for PSMC6 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH14G052740 | 0.9 | Ensembl ENCODE | 11.3 | +35.2 | 35160 | 3.4 | PKNOX1 CEBPB ZBTB40 YY1 FOXA1 ARID3A GATA2 PBX2 ZBTB33 HNF4A | STYX PSMC6 ERO1A ENSG00000259049 |
| GH14G051979 | 1 | ENCODE dbSUPER | 9.7 | -727.9 | -727886 | 0.2 | GTF2F1 CTCF TEAD4 RAD21 RFX5 ZNF791 ZNF143 SMC3 RCOR1 PRDM10 | LOC105370500 PSMC6 TMX1 LOC105370497 ENSG00000259007 |
| GH14G051980 | 1 | Ensembl dbSUPER | 9.7 | -728.1 | -728062 | 0.2 | GTF2F1 CTCF TEAD4 RAD21 RFX5 ZNF791 ZNF143 SMC3 RCOR1 PRDM10 | LOC105370500 PSMC6 TMX1 ENSG00000259007 LOC105370497 |
| GH14G052706 | 1 | ENCODE | 0.7 | +0.2 | 162 | 2.4 | HDGF PKNOX1 ARNT SIN3A DMAP1 ZNF48 YY1 ETS1 ZNF766 GATA2 | STYX PSMC6 |
| GH14G052702 | 0.9 | Ensembl ENCODE | 0.7 | -3.7 | -3654 | 1.3 | TBP MAX CEBPB EP300 ATF2 JUND CEBPA STAT3 CREB1 FOS | STYX PSMC6 ERO1A |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around PSMC6 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PSMC6 gene promoter:
Regulatory Element Products
Genomic Location for PSMC6 Gene
- Chromosome:
- 14
- Start:
- 52,707,163 bp from pter
- End:
- 52,728,587 bp from pter
- Size:
- 21,425 bases
- Orientation:
- Plus strand
Genomic View for PSMC6 Gene
Genes around PSMC6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q22.1 by Ensembl
- 14q22.1 by Entrez Gene
- 14q22.1 by HGNC
PSMC6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSMC6 Gene
Proteins for PSMC6 Gene
-
Protein details for PSMC6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62333-PRS10_HUMAN
- Recommended name:
- 26S protease regulatory subunit 10B
- Protein Accession:
- P62333
- B2R975
- P49719
- Q6IBU3
- Q92524
Protein attributes for PSMC6 Gene
- Size:
- 389 amino acids
- Molecular mass:
- 44173 Da
- Quaternary structure:
-
- Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC6 and few additional components (PubMed:27428775, PubMed:27342858). Interacts with PAAF1 (PubMed:15831487).
Protein Expression for PSMC6 Gene
Post-translational modifications for PSMC6 Gene
Other Protein References for PSMC6 Gene
Antibody Products
- Novus Biologicals Antibodies for PSMC6
-
Cloud-Clone Corp. Antibodies for PSMC6
- Invitrogen Antibodies for PSMC6
- antibodies-online Antibodies for PSMC6: See all 49
- GeneTex PSMC6 antibody for PSMC6
-
Santa Cruz Biotechnology (SCBT) Antibodies for PSMC6
Protein Products
-
OriGene Purified Proteins for PSMC6
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMC6
- Origene Custom Protein Services for PSMC6
-
Cloud-Clone Corp. Proteins for PSMC6
- antibodies-online Proteins for PSMC6: See all 14
- Search antibodies-online for peptides
- GeneTex Proteins for PSMC6
-
ProSci Proteins for PSMC6
Assay Products
- antibodies-online Kits for PSMC6: See all 2
No data available for DME Specific Peptides for PSMC6 Gene
Domains & Families for PSMC6 Gene
Gene Families for PSMC6 Gene
Protein Domains for PSMC6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PSMC6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P62333- Family:
-
- Belongs to the AAA ATPase family.
Function for PSMC6 Gene
Molecular function for PSMC6 Gene
- GENATLAS Biochemistry:
- multicatalytic proteinase complex (prosome,macropain,26kDa) 19/22S regulator of proteasome p42,ATPase subunit,44kDa
- UniProtKB/Swiss-Prot Function:
- Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0016887 | ATPase activity | TAS | 9464850 |
Phenotypes for PSMC6 Gene
- GenomeRNAi human phenotypes for PSMC6:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Decreased hepcidin::fluc mRNA expression
- Decreased ionizing radiation sensitivity
- Decreased NF-kappaB reporter expression
- FOXO1 nuclear localization
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- G0/1 arrest
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance (Z-score < -2)
- Decreased shRNA abundance
- Decreased influenza A/WSN/33 replication
- Decreased viability of wild-type and TP53 knockout cells
- Downregulation of NFkappaB pathway
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for PSMC6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMC6 gene
- Search ViGene Biosciences for PSMC6
CRISPR Products
-
OriGene CRISPR knockouts for PSMC6
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMC6
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miRNA for PSMC6 Gene
- miRTarBase miRNAs that target PSMC6
miRNA Products
- Search ViGene Biosciences for PSMC6
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for PSMC6 gene
Clone Products
- Sino Biological Human cDNA Clone for PSMC6
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- VectorBuilder custom plasmid, inducible vectors for PSMC6
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PSMC6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PSMC6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMC6 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMC6 Gene
Localization for PSMC6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PSMC6 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 3 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000502 | proteasome complex | IDA,IEA | 9464850 |
| GO:0005634 | nucleus | IDA,IEA | 10419517 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PSMC6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.78
.78
.70
.47
.31
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | Chks in Checkpoint Regulation | ||
| 4 | HIV Life Cycle |
.65
|
.45
|
| 5 | Class I MHC mediated antigen processing and presentation | ||
Pathways by source for PSMC6 Gene
1 Sino Biological pathway for PSMC6 Gene
2 BioSystems pathways for PSMC6 Gene
2 KEGG pathways for PSMC6 Gene
3 GeneGo (Thomson Reuters) pathways for PSMC6 Gene
19 Qiagen pathways for PSMC6 Gene
Interacting Proteins for PSMC6 Gene
Selected Interacting proteins:
ENSP00000401802
P62333-PRS10_HUMAN
for PSMC6 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IC | 9464850 |
No data available for SIGNOR curated interactions for PSMC6 Gene
Drugs & Compounds for PSMC6 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for PSMC6 Gene
mRNA/cDNA for PSMC6 Gene
- (2) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (475) Selected AceView cDNA sequences:
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PSMC6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PSMC6
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMC6
- GenScript: Design CRISPR guide RNA sequences for PSMC6
miRNA Products
- Search ViGene Biosciences for PSMC6
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PSMC6
- Browse OriGene Inhibitory RNA Products For PSMC6
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMC6 gene
Clone Products
- Sino Biological Human cDNA Clone for PSMC6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PSMC6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMC6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for PSMC6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMC6 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PSMC6 Gene:
PSMC6SOURCE GeneReport for Unigene cluster for PSMC6 Gene:
Hs.156171Evidence on tissue expression from TISSUES for PSMC6 Gene
- Nervous system(4.8)
- Liver(4.6)
- Muscle(3.3)
- Heart(3.1)
- Kidney(2.8)
- Lung(2.5)
- Adrenal gland(2.4)
- Blood(2.3)
- Intestine(2.2)
- Eye(2.1)
- Skin(2)
Primer Products
-
OriGene qPCR primer pairs for PSMC6
-
OriGene qPCR primer pairs and template standards for PSMC6
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMC6 Gene
Orthologs for PSMC6 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PSMC6 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PSMC6 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PSMC6 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | PSMC6 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PSMC6 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Psmc6 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Psmc6 34 |
|
||
| chicken (Gallus gallus) |
Aves | PSMC6 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PSMC6 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | psmc6 34 |
|
||
| MGC76159 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.3381 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | psmc6 34 35 |
|
||
| Dr.29047 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8441 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG7257 36 |
|
|
|
| Rpt4R 35 |
|
OneToMany | |||
| Rpt4 36 34 35 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001407 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | rpt-4 34 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPT4 34 35 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C09592g 34 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AAL113W 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | RPT4A 34 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.5748 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0199900 34 |
|
||
| Os.292 34 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.5889 34 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.14349 34 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.3972 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3434 35 |
|
OneToOne | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rpt4 34 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU07367 34 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.11771 34 |
|
- Species where no ortholog for PSMC6 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for PSMC6 Gene
(24) SIMAP similar genes for PSMC6 Gene using alignment to 9 proteins:
Pseudogenes.org Pseudogenes for PSMC6 Gene
No data available for Paralogs for PSMC6 Gene
Variants for PSMC6 Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000031124 | -- | 52,705,178(+) | TTGCA(A/G)TGAGC | upstream-variant-2KB | |
| rs1000077396 | -- | 52,710,716(+) | AAGCT(A/G)TACAT | intron-variant, utr-variant-5-prime | |
| rs1000367724 | -- | 52,717,302(+) | AAATT(C/T)TAATG | intron-variant | |
| rs1000402885 | -- | 52,725,205(+) | GCTTT(C/G)GTTAG | intron-variant | |
| rs1000424289 | -- | 52,724,540(+) | GCTGC(A/G)AAATG | intron-variant |
Residual Variation Intolerance Score:
25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.38;
8.34% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PSMC6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PSMC6
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMC6 Gene
Disorders for PSMC6 Gene
Relevant External Links for PSMC6
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- PSMC6
No disorders were found for PSMC6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMC6 Gene
Publications for PSMC6 Gene
- Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N. … Tanaka K. (Biochem. Biophys. Res. Commun. 1998) 2 3 22 64
- cDNA cloning of p42, a shared subunit of two proteasome regulatory proteins, reveals a novel member of the AAA protein family. (PMID: 8674546) Fujiwara T. … Demartino G.N. (FEBS Lett. 1996) 2 3 4 64
- Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X. … Huang L. (Biochemistry 2007) 3 4 64
- Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. (PMID: 15831487) Park Y. … Yoon J.-B. (Mol. Cell. Biol. 2005) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for PSMC6 Gene
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- ViGene Biosciences adenoviral particle packaged cDNA for PSMC6 gene
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- VectorBuilder custom plasmid, inducible vectors for PSMC6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMC6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for PSMC6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer