PSMC6 Gene(Protein Coding)

Proteasome 26S Subunit, ATPase 6

GCID:: GC14P052707

GIFtS:: 63

Genes Participants

Aliases for PSMC6 Gene

Proteasome 26S Subunit, ATPase 6 ² ³ ⁵
Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 6 ² ³
26S Proteasome AAA-ATPase Subunit RPT4 ³ ⁴
Proteasome 26S Subunit ATPase 6 ³ ⁴
Proteasome Subunit P42 ³ ⁴
SUG2 ³ ⁴
26S Protease Regulatory Subunit S10B ³

Conserved ATPase Domain Protein 44 ³
Epididymis Secretory Protein Li 73 ³
HEL-S-73 ³
CADP44 ³
P42 ³
P44 ³

External Ids for PSMC6 Gene

HGNC: 9553
Entrez Gene: 5706
Ensembl: ENSG00000100519
OMIM: 602708
UniProtKB: P62333

Previous GeneCards Identifiers for PSMC6 Gene

GC14P050496
GC14P046969
GC14P051163
GC14P052243
GC14P053173
GC14P033334

Export aliases for PSMC6 gene to outside databases

Summaries for PSMC6 Gene

Entrez Gene Summary for PSMC6 Gene

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMC6 Gene

PSMC6 (Proteasome 26S Subunit, ATPase 6) is a Protein Coding gene. Diseases associated with PSMC6 include phaeochromocytoma. Among its related pathways are Epstein-Barr virus infection and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include hydrolase activity and protein binding, bridging.

UniProtKB/Swiss-Prot for PSMC6 Gene

PRS10_HUMAN,P62333

The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

Gene Wiki entry for PSMC6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMC6 Gene

Genomics for PSMC6 Gene

Regulatory Elements for PSMC6 Gene

Enhancers for PSMC6 Gene

GeneHancer Identifier	Score	Enhancer Sources	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites within enhancer	Other Gene Targets for Enhancer

Enhancers around PSMC6 on UCSC Golden Path with GeneCards custom track

Promoters for PSMC6 Gene

Ensembl Regulatory Elements (ENSRs)	TSS Distance (bp)	Size (bp)	Binding Sites for Transcription Factors within promoters

ENSRs around PSMC6 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PSMC6 gene promoter:

See All at QIAGEN

Regulatory Element Products

Genomic Location for PSMC6 Gene

Chromosome:: 14

Start:: 52,707,163 bp from pter
End:: 52,728,587 bp from pter

Size:: 21,425 bases
Orientation:: Plus strand

Genomic View for PSMC6 Gene

Genes around PSMC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

14q22.1 by Ensembl
14q22.1 by Entrez Gene
14q22.1 by HGNC

PSMC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for PSMC6 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PSMC6 Gene

Proteins for PSMC6 Gene

Protein details for PSMC6 Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

P62333-PRS10_HUMAN

Recommended name:

26S protease regulatory subunit 10B

Protein Accession:

P62333

Secondary Accessions:
- B2R975
- P49719
- Q6IBU3
- Q92524
Protein attributes for PSMC6 Gene
Size:

389 amino acids

Molecular mass:

44173 Da
Quaternary structure:
Found in the multi-protein complexes: the 26S proteasome (formed from the 20S proteasome and PA700), and the modulator. PA700 consists of 28 subunits arranged to form a cylinder-shaped complex by four stacked rings, each containing seven subunits. Interacts with PAAF1.

neXtProt entry for PSMC6 Gene

Proteomics data for PSMC6 Gene at MOPED

Protein Expression for PSMC6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PSMC6 Gene

Ubiquitination at Lys 7, Lys 20, Lys 48, Lys 168, Lys 180, Lys 197, Lys 274, Lys 298, Lys 314, Lys 322, Lys 333, and Lys 369
- NX_P62333
Modification sites at PhosphoSitePlus
- P62333

Other Protein References for PSMC6 Gene

ENSEMBL proteins:

REFSEQ proteins:

NP_002797.3

Antibody Products

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OriGene Antibodies for PSMC6
- TA308946
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Novus Biologicals Antibodies for PSMC6

Abcam antibodies for PSMC6 (P62333)

Cloud-Clone Corp. Antibodies for PSMC6
- PAG276Hu01

Invitrogen Antibodies for PSMC6

antibodies-online Antibodies for PSMC6: See all 49

GeneTex PSMC6 antibody for PSMC6

Santa Cruz Biotechnology (SCBT) Antibodies for PSMC6

Protein Products

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OriGene Purified Proteins for PSMC6
- NM_002806
- NM_002806
- NM_002806
- NM_002806
- NM_002806
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Novus Biologicals proteins and lysates for PSMC6

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Cloud-Clone Corp. Proteins for PSMC6
- RPG276Hu01

Search eBioscience for PSMC6 related proteins

antibodies-online Proteins for PSMC6: See all 14
Search antibodies-online for peptides

GeneTex PSMC6 Recombinant Protein (GTX48153-PRO) for PSMC6

Assay Products

Browse Kits and Assays available from EMD Millipore

GenScript Custom Assay Services for PSMC6

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Browse Assay Kits at Cloud-Clone Corp.

Search eBioscience for PSMC6 related elisas

antibodies-online Kits for PSMC6: See all 2

No data available for DME Specific Peptides for PSMC6 Gene

Domains & Families for PSMC6 Gene

Gene Families for PSMC6 Gene

HGNC:

Protein Domains for PSMC6 Gene

InterPro:

Blocks:

AAA-protein subdomain

ProtoNet:

P62333

Suggested Antigen Peptide Sequences for PSMC6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62333

UniProtKB/Swiss-Prot:

PRS10_HUMAN :

Belongs to the AAA ATPase family.

Family:

Belongs to the AAA ATPase family.

Function for PSMC6 Gene

Molecular function for PSMC6 Gene

GENATLAS Biochemistry:

multicatalytic proteinase complex (prosome,macropain,26kDa) 19/22S regulator of proteasome p42,ATPase subunit,44kDa

PSMC6

UniProtKB/Swiss-Prot Function:

The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

PRS10_HUMAN,P62333

Gene Ontology (GO) - Molecular Function for PSMC6 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016787	hydrolase activity	IEA	--
GO:0030674	protein binding, bridging	NAS	11590019

Phenotypes for PSMC6 Gene

GenomeRNAi human phenotypes for PSMC6:

Animal Model Products

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ViGene Biosciences lentiviral particle packaged cDNA for PSMC6 gene
- LH887672
ViGene Biosciences ready-to-package AAV shRNAs for PSMC6 gene
- SH887672
Search ViGene Biosciences for PSMC6

CRISPR Products

OriGene CRISPR knockouts for PSMC6
- KN202809
- KN314114

Santa Cruz Biotechnology (SCBT) CRISPR for PSMC6

GenScript: Design CRISPR guide RNA sequences for PSMC6

miRNA for PSMC6 Gene

miRTarBase miRNAs that target PSMC6

hsa-mir-26b-5p (MIRT028910)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMC6 Gene

Localization for PSMC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMC6 Gene

Cytoplasm. Nucleus.

P62333-PRS10_HUMAN

Subcellular locations from

COMPARTMENTS

Jensen Localization Image for PSMC6 Gene

Compartment	Confidence
cytosol	5
extracellular	5
nucleus	5
plasma membrane	3
cytoskeleton	2
peroxisome	2

Gene Ontology (GO) - Cellular Components for PSMC6 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	TAS	--
GO:0008540	proteasome regulatory particle, base subcomplex	IBA	--
GO:0031595	nuclear proteasome complex	IBA	--
GO:0070062	extracellular exosome	IDA	19056867

Pathways & Interactions for PSMC6 Gene

SuperPathways for PSMC6 Gene

More details on SuperPathways for PSMC6

	Superpath	Contained pathways
1	CDK-mediated phosphorylation and removal of Cdc6	Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins .95 Cdc20-Phospho-APC/C mediated degradation of Cyclin A .95 Autodegradation of the E3 ubiquitin ligase COP1 .94 CDK-mediated phosphorylation and removal of Cdc6 .94 Regulation of activated PAK-2p34 by proteasome mediated degradation .94 Stabilization of p53 .94 Ubiquitin-dependent degradation of Cyclin D .94 Ubiquitin-dependent degradation of Cyclin D1 .94 APC/C-Cdc20 mediated degradation of Securin .93 APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1 .93 APC/C-mediated degradation of cell cycle proteins .93 Orc1 removal from chromatin .93 Regulation of APC/C activators between G1/S and early anaphase .93 Regulation of DNA replication .93 Regulation of mitotic cell cycle .93 Switching of origins to a post-replicative state .93 DNA Replication .92 Regulation of Apoptosis .92 Synthesis of DNA .92 Vpu mediated degradation of CD4 .92 Autodegradation of Cdh1 by Cdh1-APC/C .91 p53-Independent DNA Damage Response .91 p53-Independent G1/S DNA damage checkpoint .91 SCF-beta-TrCP mediated degradation of Emi1 .91 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A .91 APC/C-Cdc20 mediated degradation of mitotic proteins .89 APC-Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint .89 Assembly of the pre-replicative complex .89 Degradation of GLI1 by the proteasome .89 Degradation of GLI2 by the proteasome .89 GLI3 is processed to GLI3R by the proteasome .89 Hedgehog ligand biogenesis .89 Hh mutants abrogate ligand secretion .89 Vif-mediated degradation of APOBEC3G .89 AUF1 (hnRNP D0) binds and destabilizes mRNA .87	CDT1 association with the CDC6-ORC-origin complex .87 Cyclin E associated events during G1/S transition .87 Degradation of AXIN .87 SCF(Skp2)-mediated degradation of p27/p21 .87 Cyclin A-Cdk2-associated events at S phase entry .86 Hh mutants that dont undergo autocatalytic processing are degraded by ERAD .86 p53-Dependent G1 DNA Damage Response .86 p53-Dependent G1/S DNA damage checkpoint .86 NIK-->noncanonical NF-kB signaling .85 Removal of licensing factors from origins .85 Degradation of DVL .84 Dectin-1 mediated noncanonical NF-kB signaling .83 G1/S DNA Damage Checkpoints .83 DNA Replication Pre-Initiation .82 M/G1 Transition .82 Cross-presentation of soluble exogenous antigens (endosomes) .81 Regulation of ornithine decarboxylase (ODC) .80 The role of GTSE1 in G2/M progression after G2 checkpoint .80 Proteasome .79 Antigen processing-Cross presentation .79 ER-Phagosome pathway .79 S Phase .78 Activation of NF-kappaB in B cells .76 Asymmetric localization of PCP proteins .75 Regulation of RAS by GAPs .70 PCP/CE pathway .69 Immune response Antigen presentation by MHC class I .64 Beta-catenin independent WNT signaling .63 Degradation of beta-catenin by the destruction complex .63 FCERI mediated NF-kB activation .63 Regulation of mRNA stability by proteins that bind AU-rich elements .63 TNFR2 non-canonical NF-kB pathway .60 Metabolism of polyamines .59 Proteasome Degradation .59 MAPK6/MAPK4 signaling .56
2	Interleukin-3, 5 and GM-CSF signaling	ARMS-mediated activation .95 DAP12 signaling .95 Downstream signaling of activated FGFR1 .95 Frs2-mediated activation .95 GRB2 events in EGFR signaling .95 MAPK1/MAPK3 signaling .95 Prolonged ERK activation events .95 RAF/MAP kinase cascade .95 SHC1 events in EGFR signaling .95 SHC1 events in ERBB4 signaling .95 Signaling by FGFR4 .95 Signaling by Leptin .95 Signalling to ERKs .95 Signalling to p38 via RIT and RIN .95 SOS-mediated signalling .95 VEGFR2 mediated cell proliferation .95 Downstream signal transduction .94 FRS-mediated FGFR1 signaling .94 FRS-mediated FGFR2 signaling .94 FRS-mediated FGFR3 signaling .94 FRS-mediated FGFR4 signaling .94 Interleukin receptor SHC signaling .94 Interleukin-2 signaling .94 Interleukin-3, 5 and GM-CSF signaling .94 Signaling by FGFR1 .94 Signaling by FGFR3 .94 Signaling by PDGF .94	Signalling to RAS .94 Downstream signaling of activated FGFR2 .93 Downstream signaling of activated FGFR3 .93 Downstream signaling of activated FGFR4 .93 Signaling by EGFR .93 Insulin receptor signalling cascade .92 Signaling by FGFR .92 Signaling by FGFR2 .92 Signaling by Insulin receptor .92 DAP12 interactions .91 IRS-mediated signalling .91 IGF1R signaling cascade .90 IRS-related events triggered by IGF1R .90 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) .90 NCAM signaling for neurite out-growth .88 NGF signalling via TRKA from the plasma membrane .88 FCERI mediated MAPK activation .87 MAPK family signaling cascades .86 Signaling by ERBB4 .85 Signaling by SCF-KIT .85 Signalling by NGF .83 VEGFA-VEGFR2 Pathway .78 Fc epsilon receptor (FCERI) signaling .76 Signaling by VEGF .76 Signaling by Interleukins .67 Cytokine Signaling in Immune system .63 Gastrin-CREB signalling pathway via PKC and MAPK .55
3	Chks in Checkpoint Regulation	Chks in Checkpoint Regulation .59 G2-M Phase Transition .59 Estrogen-mediated S-Phase Entry .55	SREBP Proteolysis .43 DNA Repair Mechanisms .32 Parkinson's Disease Pathway .31
4	Infectious disease	HIV Infection .64 Infectious disease .64	Host Interactions of HIV factors .58 Disease .48
5	Immune System	Immune System .52 Innate Immune System .52	Adaptive Immune System .48

Pathways by source for PSMC6 Gene

2 BioSystems pathways for PSMC6 Gene

163 Reactome pathways for PSMC6 Gene

2 KEGG pathways for PSMC6 Gene

3 GeneGo (Thomson Reuters) pathways for PSMC6 Gene

19 Qiagen pathways for PSMC6 Gene

Interacting Proteins for PSMC6 Gene

http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000401802%0d%0a9606.ENSP00000310572%0d%0a9606.ENSP00000414359%0d%0a9606.ENSP00000215071%0d%0a9606.ENSP00000440485%0d%0a9606.ENSP00000348442%0d%0a — STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins: P62333-PRS10_HUMAN ENSP00000401802 for PSMC6 Gene via MINT STRING UniProtKB I2D

Symbol	External ID(s)	Details
PSMD9	O00233 ¹⁹ ⁴ ²¹ ENSP00000440485 ²⁰ ENSP00000443772 ²⁰	MINT-67981 STRING: ENSP00000440485 STRING: ENSP00000443772 EBI-357669, EBI-750973 I2D: score=8
PSMC5	P62195 ¹⁹ ⁴ ²¹ ENSP00000310572 ²⁰	MINT-4050722 MINT-7945693 MINT-2794152 MINT-7947479 STRING: ENSP00000310572 EBI-357669, EBI-357745 I2D: score=10
PSMC1	P62191 ¹⁹ ⁴ ²¹ ENSP00000261303 ²⁰	MINT-4050722 MINT-7945693 MINT-7947479 STRING: ENSP00000261303 EBI-357669, EBI-357598 I2D: score=5
PSMC3	P17980 ¹⁹ ⁴ ²¹ ENSP00000298852 ²⁰	MINT-4050722 MINT-7945693 MINT-7947479 STRING: ENSP00000298852 EBI-357669, EBI-359720 I2D: score=8
PSMC4	P43686 ¹⁹ ⁴ ²¹ ENSP00000157812 ²⁰	MINT-4050722 MINT-7945693 MINT-7947479 STRING: ENSP00000157812 EBI-357669, EBI-743997 I2D: score=9

Gene Ontology (GO) - Biological Process for PSMC6 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	TAS	--
GO:0000186	activation of MAPKK activity	TAS	--
GO:0000209	protein polyubiquitination	TAS	--
GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS	--
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	TAS	--

No data available for SIGNOR curated interactions for PSMC6 Gene

Drugs & Compounds for PSMC6 Gene

(19) Drugs for PSMC6 Gene - From: DGIdb and Novoseek

Name	Status	Disease Links	Group	Role	Mechanism of Action	Clinical Trials
Bortezomib	Approved, Experimental, Investigational	MalaCards Medline Plus	Pharma	inhibitor, other	Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors	776
carfilzomib	Approved	MalaCards Medline Plus	Pharma	other, Inhibitor	Other, 20S Proteasome Inhibitor	0

(11) Additional Compounds for PSMC6 Gene - From: Novoseek

Name	Synonyms	Role	CAS Number	PubChem IDs	PubMed IDs

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Transcripts for PSMC6 Gene

mRNA/cDNA for PSMC6 Gene

(1) REFSEQ mRNAs :

NM_002806.3

(9) Additional mRNA sequences :

(475) Selected AceView cDNA sequences:

(19) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PSMC6 Gene

Proteasome (prosome, macropain) 26S subunit, ATPase, 6:

Hs.156171

Representative Sequences:

AK127456

CRISPR Products

OriGene CRISPR knockouts for PSMC6
- KN202809
- KN314114

Santa Cruz Biotechnology (SCBT) CRISPR for PSMC6

GenScript: Design CRISPR guide RNA sequences for PSMC6

miRNA Products

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SwitchGear PSMC6 3' UTR sequence
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Inhibitory RNA Products

Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for PSMC6
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ViGene Biosciences ready-to-package AAV shRNAs for PSMC6 gene
- SH887672

Search Santa Cruz Biotechnology (SCBT) for PSMC6 siRNA/shRNA

Clone Products

OriGene clones in human for PSMC6
OriGene ORF clones in human,mouse,rat for PSMC6
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

GenScript: cDNA clones in your preferred vector
- NM_002806

Sino Biological Human cDNA Clone for PSMC6

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Flow Cytometry Products

eBioscience FlowRNA Probe Sets

Alternative Splicing Database (ASD) splice patterns (SP) for PSMC6 Gene

No ASD Table

Relevant External Links for PSMC6 Gene

GeneLoc Exon Structure for: PSMC6
ECgene alternative splicing isoforms for: PSMC6

Expression for PSMC6 Gene

mRNA expression in normal human tissues for PSMC6 Gene

mRNA expression by BioGPS for PSMC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Thymus (Hematopoietic System)
- Thymus

Protein differential expression in normal tissues from HIPED for PSMC6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMC6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMC6 Gene

Integrated proteomics: cell line protein expression from ProteomicsDB, MOPED and MaxQB for PSMC6 Gene

SOURCE GeneReport for Unigene cluster for PSMC6 Gene Hs.156171

Protein tissue co-expression partners for PSMC6 Gene

- Elite partner

Primer Products

OriGene qPCR primer pairs for PSMC6
- HP206431
OriGene qPCR primer pairs and template standards for PSMC6
- HK205967

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMC6 Gene

Orthologs for PSMC6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMC6 Gene

Organism	Taxonomy	Gene	Similarity	Type	Details
cow (Bos Taurus)	Mammalia	PSMC6 ³⁵	95.46 (n) 99.74 (a)		518637 NM_001046240.2 NP_001039705.1
cow (Bos Taurus)	Mammalia	PSMC6 ³⁶	100 (a)	OneToOne	10:11401913-11425951
dog (Canis familiaris)	Mammalia	PSMC6 ³⁵	96.44 (n) 100 (a)		478522 XM_535701.4 XP_535701.2
dog (Canis familiaris)	Mammalia	PSMC6 ³⁶	100 (a)	OneToOne	32:35815133-35816317
mouse (Mus musculus)	Mammalia	Psmc6 ³⁵	93.14 (n) 100 (a)		67089 NM_025959.3 NP_080235.2
		Psmc6 ¹⁶			45329824
		Psmc6 ³⁶	100 (a)	OneToOne	14:45329824-45349071
chimpanzee (Pan troglodytes)	Mammalia	PSMC6 ³⁵	100 (n) 100 (a)		452909 XM_001159476.3 XP_001159476.1
chimpanzee (Pan troglodytes)	Mammalia	PSMC6 ³⁶	100 (a)	OneToOne	14:51655461-51677943
rat (Rattus norvegicus)	Mammalia	Psmc6 ³⁵	92.89 (n) 99.75 (a)		289990 NM_001100509.1 NP_001093979.1
oppossum (Monodelphis domestica)	Mammalia	PSMC6 ³⁶	100 (a)	OneToOne	1:299198293-299235354
platypus (Ornithorhynchus anatinus)	Mammalia	PSMC6 ³⁶	94 (a)	OneToOne	Contig8742:8282-21637
chicken (Gallus gallus)	Aves	PSMC6 ³⁵	85.09 (n) 99.74 (a)		423586 NM_001006494.1 NP_001006494.1
chicken (Gallus gallus)	Aves	PSMC6 ³⁶	91 (a)	OneToOne	5:58108786-58120487
lizard (Anolis carolinensis)	Reptilia	PSMC6 ³⁶	99 (a)	OneToOne	GL343527.1:1977-19274
tropical clawed frog (Silurana tropicalis)	Amphibia	MGC76159 ³⁵			BC064227.1
tropical clawed frog (Silurana tropicalis)	Amphibia	psmc6 ³⁵	83.2 (n) 98.97 (a)		394968 NM_204011.1 NP_989342.1
African clawed frog (Xenopus laevis)	Amphibia	Xl.3381 ³⁵			BC045087.1
zebrafish (Danio rerio)	Actinopterygii	Dr.29047 ³⁵			57039195
		psmc6 ³⁵	78.75 (n) 97.17 (a)		321585 NM_001003832.1 NP_001003832.1
		psmc6 ³⁶	97 (a)	OneToOne	20:9944195-9957165
rainbow trout (Oncorhynchus mykiss)	Actinopterygii	Omy.8441 ³⁵			BX868329.1
fruit fly (Drosophila melanogaster)	Insecta	CG7257 ³⁷	81 (a)
		Rpt4 ³⁷	88 (a)
		Rpt4 ³⁵	70.22 (n) 89.35 (a)		31567 NM_132080.3 NP_572308.3
		Rpt4 ³⁶	87 (a)	OneToMany	X:6183503-6185276
		Rpt4R ³⁶	80 (a)	OneToMany	3L:11935123-11936585
African malaria mosquito (Anopheles gambiae)	Insecta	AgaP_AGAP001407 ³⁵	69.44 (n) 89.87 (a)		1281769 XM_321726.5 XP_321726.5
worm (Caenorhabditis elegans)	Secernentea	rpt-4 ³⁵	67.86 (n) 81.79 (a)		173384 NM_001026942.3 NP_001022113.1
worm (Caenorhabditis elegans)	Secernentea	rpt-4 ³⁶	79 (a)	OneToOne	II:42207-46216
A. gosspyii yeast (Ashbya gossypii)	Saccharomycetes	AGOS_AAL113W ³⁵	61.9 (n) 69.61 (a)		4618495 NM_207782.1 NP_982429.1
K. lactis yeast (Kluyveromyces lactis)	Saccharomycetes	KLLA0C09592g ³⁵	62.23 (n) 69.19 (a)		2892259 XM_452625.1 XP_452625.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RPT4 ³⁵	64.4 (n) 68.59 (a)		854433 NP_014902.3
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RPT4 ³⁶	60 (a)	OneToOne	XV:812395-813708
thale cress (Arabidopsis thaliana)	eudicotyledons	RPT4A ³⁵	69.55 (n) 77.23 (a)		834316 NM_123667.3 NP_199115.1
Alicante grape (Vitis vinifera)	eudicotyledons	Vvi.5748 ³⁵			CD719940.1
barley (Hordeum vulgare)	Liliopsida	Hv.5889 ³⁵			BJ464645.1
rice (Oryza sativa)	Liliopsida	Os.292 ³⁵			AB033536.1
rice (Oryza sativa)	Liliopsida	Os02g0199900 ³⁵	68.74 (n) 77.46 (a)		4328642 NM_001052753.1 NP_001046218.1
wheat (Triticum aestivum)	Liliopsida	Ta.14349 ³⁵			CK161301.1
corn (Zea mays)	Liliopsida	Zm.3972 ³⁵			AY109445.1
sea squirt (Ciona intestinalis)	Ascidiacea	Cin.11771 ³⁵			AK117044.1
bread mold (Neurospora crassa)	Ascomycetes	NCU07367 ³⁵	61.84 (n) 74.94 (a)		3875020 XM_953767.2 XP_958860.2
fission yeast (Schizosaccharomyces pombe)	Schizosaccharomycetes	rpt4 ³⁵	63.79 (n) 73.89 (a)		2539189 NP_587809.2
sea squirt (Ciona savignyi)	Ascidiacea	CSA.3434 ³⁶	90 (a)	OneToOne	reftig_1:2804918-2810343

Species with no ortholog for PSMC6:

Actinobacteria (Mycobacterium tuberculosis)
alpha proteobacteria (Wolbachia pipientis)
amoeba (Dictyostelium discoideum)
Archea (Pyrococcus horikoshii)
beta proteobacteria (Neisseria meningitidis)
Chromalveolata (Phytophthora infestans)
common water flea (Daphnia pulex)
E. coli (Escherichia coli)
filamentous fungi (Aspergillus nidulans)
Firmicute bacteria (Streptococcus pneumoniae)
green algae (Chlamydomonas reinhardtii)
honey bee (Apis mellifera)
loblloly pine (Pinus taeda)
malaria parasite (Plasmodium falciparum)
medicago trunc (Medicago Truncatula)
moss (Physcomitrella patens)
orangutan (Pongo pygmaeus)
pig (Sus scrofa)
rice blast fungus (Magnaporthe grisea)
schistosome parasite (Schistosoma mansoni)
sea anemone (Nematostella vectensis)
sea urchin (Strongylocentrotus purpuratus)
sorghum (Sorghum bicolor)
soybean (Glycine max)
stem rust fungus (Puccinia graminis)
sugarcane (Saccharum officinarum)
tomato (Lycopersicon esculentum)
toxoplasmosis (Toxoplasma gondii)
Trichoplax (Trichoplax adhaerens)

Evolution for PSMC6 Gene

ENSEMBL:: Gene Tree for PSMC6 (if available)
TreeFam:: Gene Tree for PSMC6 (if available)

Paralogs for PSMC6 Gene

(24) SIMAP similar genes for PSMC6 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for PSMC6 Gene

No data available for Paralogs for PSMC6 Gene

Variants for PSMC6 Gene

Sequence variations from dbSNP and Humsavar for PSMC6 Gene

SNP ID	Clin	Chr 14 pos	Sequence Context	Type
rs7140826	--	52,714,475(+)	AACAG(A/G)CCATG	intron-variant
rs7142734	--	52,712,028(+)	GAACA(A/G)TCAAA	intron-variant
rs2884343	--	52,725,639(+)	TATCT(C/T)CCAGT	intron-variant
rs767669	--	52,715,641(+)	taagg(G/T)gttac	intron-variant
rs1803069	--	52,711,481(+)	TTATT(C/T)TGAGA	nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PSMC6 Gene

Variant ID	Type	Subtype	PubMed ID
nsv832796	CNV	Loss	17160897
esv2090227	CNV	Deletion	18987734

Variation tolerance for PSMC6 Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)

Gene Damage Index Score: 0.38; 8.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMC6 Gene

HapMap Linkage Disequilibrium report: PSMC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMC6 Gene

Disorders for PSMC6 Gene

(1) MalaCards diseases for PSMC6 Gene - From: DISEASES and GeneCards

Disorder	Aliases	PubMed IDs
phaeochromocytoma	pheochromocytoma

- elite association - COSMIC cancer census association via MalaCards

Search PSMC6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSMC6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:: PSMC6

Export disorders for PSMC6 gene to outside databases

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMC6 Gene

Publications for PSMC6 Gene

cDNA cloning of p42, a shared subunit of two proteasome regulatory proteins, reveals a novel member of the AAA protein family. (PMID: 8674546) Fujiwara T. … Demartino G.N. (FEBS Lett. 1996) ² ³ ⁴ ⁶⁷
Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N. … Tanaka K. (Biochem. Biophys. Res. Commun. 1998) ² ³ ²³
Selective chemical inactivation of AAA proteins reveals distinct functions of proteasomal ATPases. (PMID: 11590019) Russell S.J. … Johnston S.A. (Chem. Biol. 2001) ³ ²³
Activator complexes containing the proteasomal regulatory ATPases S10b (SUG2) and S6 (TBP1) in different tissues and organisms. (PMID: 10363644) Hastings R. … Mayer R.J. (Mol. Biol. Rep. 1999) ³ ²³
DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. (PMID: 25756610) Papp S.J. … Lamia K.A. (Elife 2015) ³