Aliases for PSMC6 Gene
Aliases for PSMC6 Gene
External Ids for PSMC6 Gene
- HGNC: 9553
- Entrez Gene: 5706
- Ensembl: ENSG00000100519
- OMIM: 602708
- UniProtKB: P62333
Previous GeneCards Identifiers for PSMC6 Gene
- GC14P050496
- GC14P046969
- GC14P051163
- GC14P052243
- GC14P053173
- GC14P033334
Summaries for PSMC6 Gene
-
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSMC6 Gene
PSMC6 (Proteasome 26S Subunit, ATPase 6) is a Protein Coding gene. Diseases associated with PSMC6 include Ehrlichiosis. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include hydrolase activity and protein binding, bridging.
UniProtKB/Swiss-Prot for PSMC6 Gene
-
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMC6 Gene
Genomics for PSMC6 Gene
GeneHancer (GH) Regulatory Elements for PSMC6 Gene
- Top Transcription factor binding sites by QIAGEN in the PSMC6 gene promoter:
Regulatory Element Products
Genomic Locations for PSMC6 Gene
- chr14:52,707,163-52,728,587
- (GRCh38/hg38)
- Size:
- 21,425 bases
- Orientation:
- Plus strand
- chr14:53,173,890-53,195,305
- (GRCh37/hg19)
Genomic View for PSMC6 Gene
- Cytogenetic band:
-
- 14q22.1 by Ensembl
- 14q22.1 by Entrez Gene
- 14q22.1 by HGNC


RefSeq DNA sequence for PSMC6 Gene
Proteins for PSMC6 Gene
-
Protein details for PSMC6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62333-PRS10_HUMAN
- Recommended name:
- 26S proteasome regulatory subunit 10B
- Protein Accession:
- P62333
- B2R975
- P49719
- Q6IBU3
- Q92524
Protein attributes for PSMC6 Gene
- Size:
- 389 amino acids
- Molecular mass:
- 44173 Da
- Quaternary structure:
-
- Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC6 and few additional components (PubMed:27428775, PubMed:27342858). Interacts with PAAF1 (PubMed:15831487).
Protein Expression for PSMC6 Gene
Post-translational modifications for PSMC6 Gene
- Ubiquitination at isoforms=7, Lys20, isoforms=48, Lys168, isoforms=180, isoforms=197, Lys274, isoforms=298, Lys314, isoforms=322, Lys333, and isoforms=369
Other Protein References for PSMC6 Gene
Antibody Products
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Abcam antibodies for PSMC6
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-
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Protein Products
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-
ProSci Proteins for PSMC6
-
Abcam proteins for PSMC6
Assay Products
No data available for DME Specific Peptides for PSMC6 Gene
Domains & Families for PSMC6 Gene
Gene Families for PSMC6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PSMC6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PSMC6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P62333- Family:
-
- Belongs to the AAA ATPase family.
Function for PSMC6 Gene
Molecular function for PSMC6 Gene
- GENATLAS Biochemistry:
- multicatalytic proteinase complex (prosome,macropain,26kDa) 19/22S regulator of proteasome p42,ATPase subunit,44kDa
- UniProtKB/Swiss-Prot Function:
- Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Phenotypes From GWAS Catalog for PSMC6 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0005515 | protein binding | IPI | 16189514 |
GO:0005524 | ATP binding | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0016887 | ATPase activity | TAS | 9464850 |
Phenotypes for PSMC6 Gene
- GenomeRNAi human phenotypes for PSMC6:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Decreased hepcidin::fluc mRNA expression
- Decreased ionizing radiation sensitivity
- Decreased NF-kappaB reporter expression
- FOXO1 nuclear localization
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- G0/1 arrest
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance (Z-score < -2)
- Decreased shRNA abundance
- Decreased influenza A/WSN/33 replication
- Decreased viability of wild-type and TP53 knockout cells
- Downregulation of NFkappaB pathway
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-
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miRNA for PSMC6 Gene
- miRTarBase miRNAs that target PSMC6
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PSMC6 gene related products
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMC6 Gene
Localization for PSMC6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PSMC6 Gene
- Cytoplasm. Nucleus.
- Cytosol (2)
- Nucleoplasm (2)
- Plasma membrane (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000502 | proteasome complex | IDA,IEA | 9464850 |
GO:0005634 | nucleus | IEA,IDA | 10419517 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PSMC6 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.78
.78
.70
.47
.31
|
2 | RET signaling |
.92
|
.92
|
3 | Chks in Checkpoint Regulation | ||
4 | HIV Life Cycle |
.65
|
.45
|
5 | Class I MHC mediated antigen processing and presentation |
Pathways by source for PSMC6 Gene
1 Sino Biological pathway for PSMC6 Gene
2 BioSystems pathways for PSMC6 Gene
2 KEGG pathways for PSMC6 Gene
3 GeneGo (Thomson Reuters) pathways for PSMC6 Gene
19 Qiagen pathways for PSMC6 Gene
Interacting Proteins for PSMC6 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0000209 | protein polyubiquitination | TAS | -- |
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
GO:0006511 | ubiquitin-dependent protein catabolic process | IC | 9464850 |
No data available for SIGNOR curated interactions for PSMC6 Gene
Drugs & Compounds for PSMC6 Gene
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Transcripts for PSMC6 Gene
mRNA/cDNA for PSMC6 Gene
- (2) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (475) Selected AceView cDNA sequences:
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PSMC6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PSMC6
- genomics-online: gRNA clones - Search results for available PSMC6 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMC6
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miRNA Products
- Search ViGene Biosciences for PSMC6
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PSMC6
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PSMC6 gene related products
- orf clones - Search results for available PSMC6 gene related products
- Applied Biological Materials Clones for PSMC6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PSMC6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMC6 Gene
NURSA nuclear receptor signaling pathways regulating expression of PSMC6 Gene:
PSMC6SOURCE GeneReport for Unigene cluster for PSMC6 Gene:
Hs.156171Evidence on tissue expression from TISSUES for PSMC6 Gene
- Nervous system(4.8)
- Liver(4.6)
- Muscle(3.3)
- Heart(3.1)
- Kidney(2.8)
- Lung(2.5)
- Adrenal gland(2.4)
- Blood(2.3)
- Intestine(2.2)
- Eye(2.1)
- Skin(2)
Primer Products
-
OriGene qPCR primer pairs for PSMC6
-
OriGene qPCR primer pairs and template standards for PSMC6
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No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMC6 Gene
Orthologs for PSMC6 Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PSMC6 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | PSMC6 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | PSMC6 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | PSMC6 33 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | PSMC6 34 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Psmc6 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Psmc6 33 |
|
||
chicken (Gallus gallus) |
Aves | PSMC6 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | PSMC6 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | psmc6 33 |
|
||
MGC76159 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.3381 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | psmc6 33 34 |
|
||
Dr.29047 33 |
|
||||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8441 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | CG7257 35 |
|
|
|
Rpt4R 34 |
|
OneToMany | |||
Rpt4 35 33 34 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001407 33 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | rpt-4 33 34 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPT4 33 34 |
|
||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C09592g 33 |
|
||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AAL113W 33 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | RPT4A 33 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.5748 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os02g0199900 33 |
|
||
Os.292 33 |
|
||||
barley (Hordeum vulgare) |
Liliopsida | Hv.5889 33 |
|
||
wheat (Triticum aestivum) |
Liliopsida | Ta.14349 33 |
|
||
corn (Zea mays) |
Liliopsida | Zm.3972 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3434 34 |
|
OneToOne | |
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rpt4 33 |
|
||
bread mold (Neurospora crassa) |
Ascomycetes | NCU07367 33 |
|
||
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.11771 33 |
|
- Species where no ortholog for PSMC6 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for PSMC6 Gene
(24) SIMAP similar genes for PSMC6 Gene using alignment to 9 proteins:
Pseudogenes.org Pseudogenes for PSMC6 Gene
No data available for Paralogs for PSMC6 Gene
Variants for PSMC6 Gene
SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000031124 | -- | 52,705,178(+) | G/A | upstream_transcript_variant | |
rs1000077396 | -- | 52,710,716(+) | G/A | 5_prime_UTR_variant, intron_variant | |
rs1000367724 | -- | 52,717,302(+) | T/C | intron_variant | |
rs1000402885 | -- | 52,725,205(+) | G/C | intron_variant | |
rs1000424289 | -- | 52,724,540(+) | A/G | intron_variant |
Additional Variant Information for PSMC6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PSMC6
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMC6 Gene
Disorders for PSMC6 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
ehrlichiosis |
|
|
Additional Disease Information for PSMC6
No data available for UniProtKB/Swiss-Prot and Genatlas for PSMC6 Gene
Publications for PSMC6 Gene
- Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N … Tanaka K (Biochemical and biophysical research communications 1998) 2 3 22 58
- cDNA cloning of p42, a shared subunit of two proteasome regulatory proteins, reveals a novel member of the AAA protein family. (PMID: 8674546) Fujiwara T … DeMartino GN (FEBS letters 1996) 2 3 4 58
- Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4 58
- Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. (PMID: 15831487) Park Y … Yoon JB (Molecular and cellular biology 2005) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for PSMC6 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 60 available PSMC6 Antibodies ranked by validation data
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Sources for PSMC6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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