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PSMC5 Gene

protein-coding   GIFtS: 69
GCID: GC17P061904

Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5

  See PSMC5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 51 2     S82
TRIP12 3 5     SUG-12
Proteasome 26S Subunit ATPase 52 3     TBP102
Proteasome Subunit P452 3     MSUG1 Protein2
Thyroid Hormone Receptor-Interacting Protein 12 3     p452
26S Proteasome AAA-ATPase Subunit RPT62 3     Proteasome 26S ATPase Subunit 52
SUG12 3     Tat-Binding Protein Homolog 102
p45/SUG2 3     Thyroid Receptor Interactor 12
26S Protease Regulatory Subunit 82     

External Ids:    HGNC: 95521   Entrez Gene: 57052   Ensembl: ENSG000000871917   OMIM: 6016815   UniProtKB: P621953   

Export aliases for PSMC5 gene to outside databases

Previous GC identifers: GC17P061555 GC17P064331 GC17P062245 GC17P062378 GC17P059258 GC17P057272


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PSMC5 Gene:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes,
a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are
composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a
base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in
an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome,
the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a
member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in
proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to
interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Nov 2010)

GeneCards Summary for PSMC5 Gene:
PSMC5 (proteasome (prosome, macropain) 26S subunit, ATPase, 5) is a protein-coding gene. Diseases associated with PSMC5 include indolent systemic mastocytosis, and mulibrey nanism. GO annotations related to this gene include transcription cofactor activity and transcription factor binding.

UniProtKB/Swiss-Prot: PRS8_HUMAN, P62195
Function: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory
(or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex

Gene Wiki entry for PSMC5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PSMC5 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSMC5 promoter sequence
   Search Chromatin IP Primers for PSMC5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSMC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.3   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q23.3

PSMC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMC5 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P061904:  view genomic region     (about GC identifiers)

Start:
61,904,512 bp from pter      End:
61,909,387 bp from pter
Size:
4,876 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PRS8_HUMAN, P62195 (See protein sequence)
Recommended Name: 26S protease regulatory subunit 8  
Size: 406 amino acids; 45626 Da
Subunit: Interacts, in vitro, with the thyroid hormone receptor (in a thyroid hormone T3-dependent manner) and
with retinoid X receptor (RXR) (By similarity). Interacts with NDC80. Interacts with PAAF1. Interacts with TRIM5.
Component of a complex with USP49 and RUVBL1
2 PDB 3D structures from and Proteopedia for PSMC5:
2KRK (3D)        3KW6 (3D)    
Secondary accessions: A8K3Z3 A8K763 O35051 O43208 P47210 P52915 P52916
Alternative splicing: 2 isoforms:  P62195-1   P62195-2   

Explore the universe of human proteins at neXtProt for PSMC5: NX_P62195

Explore proteomics data for PSMC5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys15, Lys27, Lys38, Lys88, Lys94, Lys101, Lys125, Lys130, Lys142, Lys170,
                                 Lys196, Lys222, Lys330, Lys397
  • Modification sites at PhosphoSitePlus

  • See PSMC5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186092.1  NP_002796.4  

    ENSEMBL proteins: 
     ENSP00000464405   ENSP00000310572   ENSP00000463549   ENSP00000463801   ENSP00000462098  
     ENSP00000464602   ENSP00000462495   ENSP00000464646   ENSP00000463107   ENSP00000463938  
     ENSP00000464347   ENSP00000364970  
    Reactome Protein details: P62195

    PSMC5 Human Recombinant Protein Products:

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    Novus Biologicals PSMC5 Protein
    Novus Biologicals PSMC5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PSMC5

     
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    antibodies-online proteins for PSMC5 (8 products) 

     
    antibodies-online peptides for PSMC5

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    antibodies-online antibodies for PSMC5 (24 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AATP: ATPases / AAA-type
    PSM: Proteasome (prosome, macropain) subunits

    5 InterPro protein domains:
     IPR003959 ATPase_AAA_core
     IPR003960 ATPase_AAA_CS
     IPR027417 P-loop_NTPase
     IPR005937 26S_Psome_P45
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry P62195

    ProtoNet protein and cluster: P62195

    1 Blocks protein domain: IPB011072 Protein kinase PKN/PRK1

    UniProtKB/Swiss-Prot: PRS8_HUMAN, P62195
    Similarity: Belongs to the AAA ATPase family


    Find genes that share domains with PSMC5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRS8_HUMAN, P62195
    Function: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory
    (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex

         Genatlas biochemistry entry for PSMC5:
    multicatalytic proteinase complex (proteasome,macropain,26S) 19/22S regulator of proteasome ,ATPase subunit,46kDa

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003712transcription cofactor activity TAS7870181
    GO:0005102receptor binding ----
    GO:0005515protein binding IPI16189514
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with PSMC5           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for PSMC5:
     Decreased viability of wild-ty  G0/1 arrest  Increased G1 DNA content  Increased cell death in breast 
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PSMC5

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for PSMC5 (see all 604):
    ABCD3,  ACVR1C,  ACVR2A,  ADAMTS2,  ADAMTSL2,  ADH4,  ADH5,  ADNP2,  AFF2,  AGAP11

    miRNA
    Products:
        
    miRTarBase miRNAs that target PSMC5:
    hsa-mir-324-5p (MIRT043146), hsa-mir-193b-3p (MIRT041377), hsa-mir-484 (MIRT041740), hsa-mir-1229-3p (MIRT036390)

    Block miRNA regulation of human, mouse, rat PSMC5 using miScript Target Protectors
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    Inhib. RNA
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): PSMC5 (NM_002805)
    Sino Biological Human cDNA Clone for PSMC5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSMC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMC5
    Addgene plasmids for PSMC5 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMC5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRS8_HUMAN, P62195: Cytoplasm (Potential). Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    peroxisome2

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex IDA9464850
    GO:0005634nucleus IDA9927201
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA9927201
    GO:0005829cytosol TAS--

    Find genes that share ontologies with PSMC5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PSMC5 About   (see all 29)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    CDK-mediated phosphorylation and removal of Cdc60.94
    Destabilization of mRNA by AUF1 (hnRNP D0)0.88
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    G1/S DNA Damage Checkpoints0.87
    Ubiquitin-dependent degradation of Cyclin D10.94
    CDT1 association with the CDC6-ORC-origin complex0.87
    Ubiquitin-dependent degradation of Cyclin D0.94
    SCF(Skp2)-mediated degradation of p27/p210.86
    2Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Chks in Checkpoint Regulation
    Chks in Checkpoint Regulation0.59
    SREBP Proteolysis0.43
    G2-M Phase Transition0.59
    DNA Repair Mechanisms0.32
    Estrogen-mediated S-Phase Entry0.55
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90


    Find genes that share SuperPaths with PSMC5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PSMC5 (see all 19)
        Remodeling of Adherens Junctions
    CDK5 Pathway
    Estrogen-mediated S-Phase Entry
    G2-M Phase Transition
    DNA Repair Mechanisms

    3 GeneGo (Thomson Reuters) Pathways for PSMC5
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Antigen presentation by MHC class I

    2 BioSystems Pathways for PSMC5
        Parkin-Ubiquitin Proteasomal System pathway
    Proteasome Degradation


    Selected Reactome Pathways for PSMC5 (see all 24)
        SCF(Skp2)-mediated degradation of p27/p21
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
    SCF-beta-TrCP mediated degradation of Emi1
    Ubiquitin-dependent degradation of Cyclin D1
    Orc1 removal from chromatin


    2 Kegg Pathways  (Kegg details for PSMC5):
        Proteasome
    Epstein-Barr virus infection

        Pathway & Disease-focused RT2 Profiler PCR Array including PSMC5: 
              Nuclear Receptors & Coregulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PSMC5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PSMC5 (P621951, 2, 3 ENSP000003105724) via UniProtKB, MINT, STRING, and/or I2D (see all 1146)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLEKHO1Q53GL01, 2EBI-357745,EBI-949945 MINT-8416350 MINT-8416226 MINT-8416332 MINT-8416303 MINT-8416449 MINT-8416398 MINT-8416433 MINT-8416374 MINT-8416288
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--

    Find genes that share ontologies with PSMC5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for PSMC5 (see all 16)     About this table
    CompoundAction CAS #
    Aclacinomycin ASpecific inhibitor of the 20S proteasome chymotrypsin-like activity[57576-44-0]
    AM 114Boronic-chalcone derived proteasome inhibitor with anticancer activity[856849-35-9]
    Bortezomib (PS-341, LDP-3411)Cell-permeable proteasome inhibitor[179324-69-7]
    Carfilzomib (PR-171)Proteasome inhibitor, analog of epoxomicin[868540-17-4]
    CEP-18770Orally active inhibitor of the chymotrypsin-like activity of proteasome[847499-27-8]
    DihydroeponemycinProteasome inhibitor and antitumor reagent[126463-64-7]
    EpoxomicinIrreversible proteasome inhibitor[134381-21-8]
    GliotoxinNon-competitively inhibits chymotrypsin-like activity of 20S proteasome[67-99-2]
    MG-115Reversible proteasome inhibitor--
    MG-132Cell permeable, reversible proteasome inhibitor[133407-82-6]

    Browse Tocris compounds for PSMC5 (PRS8)

    1 HMDB Compound for PSMC5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Thyrotropin-releasing factorProtirelin (see all 36)24305-27-9--

    3 Novoseek inferred chemical compound relationships for PSMC5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin d 28.8 2 14702340 (1), 9831079 (1)
    retinoic acid 15.4 1 10094499 (1)
    steroid 11.7 3 9280066 (1), 9513710 (1), 15234273 (1)



    Find genes that share compounds with PSMC5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PSMC5 gene (2 alternative transcripts): 
    NM_001199163.1  NM_002805.5  

    Unigene Cluster for PSMC5:

    Proteasome (prosome, macropain) 26S subunit, ATPase, 5
    Hs.79387  [show with all ESTs]
    Unigene Representative Sequence: NM_001199163
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000579708 ENST00000310144(uc002jcb.3) ENST00000582420 ENST00000581842
    ENST00000582130 ENST00000584320 ENST00000583283 ENST00000581764 ENST00000585123
    ENST00000579147(uc010ddy.3) ENST00000580864(uc002jcd.3) ENST00000584536
    ENST00000585242 ENST00000578570 ENST00000580265 ENST00000581882 ENST00000579031
    ENST00000584880
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSMC5
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    Addgene plasmids for PSMC5 
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PSMC5
      QuantiTect SYBR Green Assays in human, mouse, rat PSMC5
      QuantiFast Probe-based Assays in human, mouse, rat PSMC5

    Additional mRNA sequence: 

    AK290758.1 AK291878.1 BC001932.1 BC002367.2 BC127888.1 D44467.1 L38810.1 

    Selected DOTS entries (see all 31):

    DT.92474818  DT.99926666  DT.100868508  DT.318232  DT.100745357  DT.100756779  DT.92474824  DT.100745401 
    DT.100745417  DT.92474856  DT.102838780  DT.75120849  DT.95332113  DT.91723560  DT.100745437  DT.102843979 
    DT.121007197  DT.92474841  DT.95291584  DT.121007467  DT.92474941  DT.97855567  DT.121007409  DT.121007580 

    Selected AceView cDNA sequences (see all 673):

    BQ224155 BQ894125 CB145031 CB112283 BM926069 AI953691 BX325029 CB108649 
    BM790723 BC001932 BM662484 BG029666 BI752568 BQ183876 BF981181 BQ050044 
    W32287 CA487577 CA436926 BM449714 BQ952087 BM785471 BU857665 BU677860 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PSMC5 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ·
    SP1:                          -     -     -     -     -     -           -                 -           -     -                       -                 -         
    SP2:                          -     -     -     -     -     -                             -           -     -                       -                 -         
    SP3:                          -     -     -     -     -     -           -                 -           -     -     -                 -                 -         
    SP4:                                                        -           -                 -           -     -                       -                           
    SP5:                                                                    -                 -           -     -                       -                           

    ExUns: 10c ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for PSMC5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PSMC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCATCAAGA
    PSMC5 Expression
    About this image


    PSMC5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    PSMC5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PSMC5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.79387
        Pathway & Disease-focused RT2 Profiler PCR Array including PSMC5: 
              Nuclear Receptors & Coregulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PSMC5 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Psmc51 , 5 protease (prosome, macropain) 26S subunit, ATPase 51, 5 90.23(n)1
    100(a)1
      11 (68.89 cM)5
    191841  NM_008950.11  NP_032976.11 
     1062561545 
    chicken
    (Gallus gallus)
    Aves PSMC51 proteasome (prosome, macropain) 26S subunit, ATPase, more 83(n)
    98.03(a)
      428274  XM_004948510.1  XP_004948567.1 
    lizard
    (Anolis carolinensis)
    Reptilia PSMC56
    proteasome (prosome, macropain) 26S subunit, ATPas...
    86(a)
    1 ↔ 1
    6(71630181-71680265)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC045221.12   -- 82.08(n)    BC045221.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa14g022 Transcribed sequence with moderate similarity to protein more 80.45(n)    CA470973.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pros451 , 3 proteolysis and peptidolysis proteasome
    endopeptidase3
    Pros451
    92(a)
    (best of 2)3
    77.78(n)1
    93.23(a)1
      19F43
    331051  NM_134603.11  NP_608447.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rpt-61 rpt-6 70.49(n)
    84.79(a)
      176661  NM_067208.4  NP_499609.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPT6(YGL048C)4
    RPT61
    One of six ATPases of the 19S regulatory particle of more4
    RPT61
    65.04(n)1
    76.61(a)1
      7(411286-410069)4
    8528341, 4  NP_011467.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RPT6A1 RPT6A 70.31(n)
    82.95(a)
      832121  NM_122006.3  NP_568389.1 
    rice
    (Oryza sativa)
    Liliopsida Os.3172 Oryza sativa (japonica cultivar-group) OsRPT6 mRNA more 74.25(n)    AB052887.1 


    ENSEMBL Gene Tree for PSMC5 (if available)
    TreeFam Gene Tree for PSMC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PSMC5 gene
    Selected SIMAP similar genes for PSMC5 using alignment to 9 protein entries:     PRS8_HUMAN (see all proteins) (see all similar genes):
    PSMC1    PSMC6    DKFZp666D103    PEX6    PSMC2    AFG3L2
    DKFZp667C165    SPG7    ATAD2B    YME1L1    KATNAL2    PSMC4
    PSMC3    ATAD2    DKFZp434K0126    FTSH    VCP    PEX1

    Find genes that share paralogs with PSMC5           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for PSMC5
    PGOHUM00000234948 PGOHUM00000233165


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PSMC5 (see all 84)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359014
    A colorectal cancer sample4--see VAR_0359012 R Q mis40--------
    rs1415818101,2
    C--61904338(+) AGATT-/CCACTT
    CCAGTTTC
    CCACT
    2 -- us2k10--------
    rs1451686221,2
    --61907064(+) TTTCCG/TGAGCC 2 -- int10--------
    rs1509519911,2
    C--61907094(+) TACATA/GAATTT 2 -- int10--------
    rs1839222461,2
    --61907130(+) AGTGAC/TGCTTA 2 -- int10--------
    rs1410556311,2
    C--61907171(+) CTCCAA/GAGGAG 2 -- int10--------
    rs1155445921,2
    C,F--61907195(+) ACTGTG/ATCTGT 2 -- int11Minor allele frequency- A:0.03WA 118
    rs2017338141,2
    --61907297(+) AAGAAA/GGTGTT 4 K syn10--------
    rs286071001,2
    C,F--61907318(+) AAAGCA/GGCATG 2 -- int13Minor allele frequency- G:0.01WA EU 1443
    rs1883476061,2
    C--61907354(+) CTGCAG/TTCCCA 2 -- int10--------

    HapMap Linkage Disequilibrium report for PSMC5 (61904512 - 61909387 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PSMC5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833510CNV Loss17160897
    nsv510720CNV Loss20534489
    nsv517272CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PSMC5
    DNA2.0 Custom Variant and Variant Library Synthesis for PSMC5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601681    OMIM disorders: --

    2 diseases for PSMC5:    
    About MalaCards
    indolent systemic mastocytosis    mulibrey nanism

    1 disease from the University of Copenhagen DISEASES database for PSMC5:
    Indolent systemic mastocytosis

    Find genes that share disorders with PSMC5           About GenesLikeMe


    Export disorders for PSMC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PSMC5 gene, integrated from 10 sources (see all 193):
    (articles sorted by number of sources associating them with PSMC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Localization of genes encoding two human one-domain members of the AAA family: PSMC5 (the thyroid hormone receptor-interacting protein, TRIP1) and PSMC3 (the Tat-binding protein, TBP1). (PubMed id 9048938)1, 3, 9 Hoyle J....Fisher E.M. (Hum. Genet. 1997)
    2. Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PubMed id 9473509)1, 3, 9 Tanahashi N....Tanaka K. (Biochem. Biophys. Res. Commun. 1998)
    3. USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. (PubMed id 23824326)1, 2 Zhang Z....Wang H. (amp 2013)
    4. TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions. (PubMed id 22078707)1, 2 Lukic Z.... Campbell E.M. (Retrovirology 2011)
    5. Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. (PubMed id 15831487)1, 2 Park Y.... Yoon J.-B. (Mol. Cell. Biol. 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins. (PubMed id 10409732)1, 2 Zheng L.... Lee W.-H. (Mol. Cell. Biol. 1999)
    9. HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins. (PubMed id 9295362)1, 2 Chen Y.... Lee W.-H. (J. Biol. Chem. 1997)
    10. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 2 Yu W.... Gibbs R.A. (Genome Res. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5705 HGNC: 9552 AceView: PSMC5 Ensembl:ENSG00000087191 euGenes: HUgn5705
    ECgene: PSMC5 Kegg: 5705 H-InvDB: PSMC5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PSMC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PSMC5 gene:
    Search GeneIP for patents involving PSMC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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