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Aliases for PSMC5 Gene

Aliases for PSMC5 Gene

  • Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 2 3
  • TRIP1 3 4 6
  • Thyroid Hormone Receptor-Interacting Protein 1 3 4
  • 26S Proteasome AAA-ATPase Subunit RPT6 3 4
  • Proteasome 26S Subunit ATPase 5 3 4
  • Proteasome Subunit P45 3 4
  • P45/SUG 3 4
  • SUG1 3 4
  • 26S Protease Regulatory Subunit 8 3
  • Proteasome 26S ATPase Subunit 5 3
  • Tat-Binding Protein Homolog 10 3
  • Thyroid Receptor Interactor 1 3
  • MSUG1 Protein 3
  • SUG-1 3
  • TBP10 3
  • P45 3
  • S8 3

External Ids for PSMC5 Gene

Previous GeneCards Identifiers for PSMC5 Gene

  • GC17P061555
  • GC17P064331
  • GC17P062245
  • GC17P062378
  • GC17P059258
  • GC17P061904
  • GC17P057272

Summaries for PSMC5 Gene

Entrez Gene Summary for PSMC5 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for PSMC5 Gene

PSMC5 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5) is a Protein Coding gene. Diseases associated with PSMC5 include indolent systemic mastocytosis and mulibrey nanism. Among its related pathways are Signaling by GPCR and Downstream Signaling Events Of B Cell Receptor (BCR). GO annotations related to this gene include transcription factor binding and transcription cofactor activity.

UniProtKB/Swiss-Prot for PSMC5 Gene

  • The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex

Gene Wiki entry for PSMC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMC5 Gene

Genomics for PSMC5 Gene

Regulatory Elements for PSMC5 Gene

Transcription factor binding sites by QIAGEN in the PSMC5 gene promoter:

Genomic Location for PSMC5 Gene

Start:
63,827,152 bp from pter
End:
63,832,027 bp from pter
Size:
4,876 bases
Orientation:
Plus strand

Genomic View for PSMC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSMC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMC5 Gene

Proteins for PSMC5 Gene

  • Protein details for PSMC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62195-PRS8_HUMAN
    Recommended name:
    26S protease regulatory subunit 8
    Protein Accession:
    P62195
    Secondary Accessions:
    • A8K3Z3
    • A8K763
    • O35051
    • O43208
    • P47210
    • P52915
    • P52916

    Protein attributes for PSMC5 Gene

    Size:
    406 amino acids
    Molecular mass:
    45626 Da
    Quaternary structure:
    • Component of a complex with USP49 and RUVBL1. Interacts with PRPF19. Interacts with TRIM5. Interacts with NDC80. Interacts with PAAF1. Interacts, in vitro, with the thyroid hormone receptor (in a thyroid hormone T3-dependent manner) and with retinoid X receptor (RXR).

    Three dimensional structures from OCA and Proteopedia for PSMC5 Gene

    Alternative splice isoforms for PSMC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMC5 Gene

Proteomics data for PSMC5 Gene at MOPED

Post-translational modifications for PSMC5 Gene

  • Ubiquitination at Lys15, Lys27, Lys38, Lys88, Lys94, Lys101, Lys125, Lys130, Lys142, Lys170, Lys196, Lys222, Lys330, and Lys397
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSMC5 Gene

Domains for PSMC5 Gene

Gene Families for PSMC5 Gene

HGNC:
  • AATP :ATPases / AAA-type
  • PSM :Proteasome (prosome, macropain) subunits

Suggested Antigen Peptide Sequences for PSMC5 Gene

Graphical View of Domain Structure for InterPro Entry

P62195

UniProtKB/Swiss-Prot:

PRS8_HUMAN :
  • P62195
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with PSMC5: view

Function for PSMC5 Gene

Molecular function for PSMC5 Gene

GENATLAS Biochemistry: multicatalytic proteinase complex (proteasome,macropain,26S) 19/22S regulator of proteasome ,ATPase subunit,46kDa
UniProtKB/Swiss-Prot Function: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex

Gene Ontology (GO) - Molecular Function for PSMC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity TAS 7870181
GO:0005102 receptor binding --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0008134 transcription factor binding IPI 10816420
genes like me logo Genes that share ontologies with PSMC5: view
genes like me logo Genes that share phenotypes with PSMC5: view

miRNA for PSMC5 Gene

Transcription Factor Targeting for PSMC5 Gene

Selected GeneGlobe predicted Target genes for PSMC5

No data available for Enzyme Numbers (IUBMB) , Animal Models and HOMER Transcription for PSMC5 Gene

Localization for PSMC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMC5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMC5 Gene COMPARTMENTS Subcellular localization image for PSMC5 gene
Compartment Confidence
cytosol 5
nucleus 5
peroxisome 2

Gene Ontology (GO) - Cellular Components for PSMC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 17323924
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 9927201
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMC5: view

Pathways for PSMC5 Gene

SuperPathways for PSMC5 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.38
2 Chks in Checkpoint Regulation
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.62
5 Mitotic Metaphase and Anaphase
genes like me logo Genes that share pathways with PSMC5: view

Gene Ontology (GO) - Biological Process for PSMC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSMC5: view

Compounds for PSMC5 Gene

(16) ApexBio Compounds for PSMC5 Gene

Compound Action Cas Number
Aclacinomycin A Specific inhibitor of the 20S proteasome chymotrypsin-like activity [57576-44-0]
AM 114 Boronic-chalcone derived proteasome inhibitor with anticancer activity [856849-35-9]
Bortezomib (PS-341, LDP-3411) Cell-permeable proteasome inhibitor [179324-69-7]
Carfilzomib (PR-171) Proteasome inhibitor, analog of epoxomicin [868540-17-4]
CEP-18770 Orally active inhibitor of the chymotrypsin-like activity of proteasome [847499-27-8]
Dihydroeponemycin Proteasome inhibitor and antitumor reagent [126463-64-7]
Epoxomicin Irreversible proteasome inhibitor [134381-21-8]
Gliotoxin Non-competitively inhibits chymotrypsin-like activity of 20S proteasome [67-99-2]
MG-115 Reversible proteasome inhibitor
MG-132 Proteasome and calpain inhibitor. [133407-82-6]
MG-262 Boronic acid-based, reversible, cell-permeable proteasome inhibitor
MLN2238 Potent reversible and specific beta5 site of the 20S proteasome inhibitor [1072833-77-2]
MLN9708 Inhibits chymotrypsin-like proteasome activity [1201902-80-8]
ONX-0914 (PR-957) Immunoproteasome inhibitor [960374-59-8]
Oprozomib (ONX-0912) Orally bioavailable inhibitor for CT-L activity of 20S proteasome beta5/LMP7 [935888-69-0]
PSI Inhibits chymotrypsin-like proteasome activity [158442-41-2]

(1) HMDB Compounds for PSMC5 Gene

Compound Synonyms Cas Number PubMed IDs
Thyrotropin-releasing factor
  • Protirelin
24305-27-9

(3) Novoseek inferred chemical compound relationships for PSMC5 Gene

Compound -log(P) Hits PubMed IDs
vitamin d 28.8 2
retinoic acid 15.4 1
steroid 11.7 3
genes like me logo Genes that share compounds with PSMC5: view

Transcripts for PSMC5 Gene

Unigene Clusters for PSMC5 Gene

Proteasome (prosome, macropain) 26S subunit, ATPase, 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMC5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - - - - - -
SP7: -
SP8: - - -
SP9: - -
SP10: -
SP11: - -
SP12: -
SP13: -
SP14:

ExUns: 10c ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PSMC5 Gene

GeneLoc Exon Structure for
PSMC5
ECgene alternative splicing isoforms for
PSMC5

Expression for PSMC5 Gene

mRNA expression in normal human tissues for PSMC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMC5 Gene

SOURCE GeneReport for Unigene cluster for PSMC5 Gene Hs.79387

genes like me logo Genes that share expressions with PSMC5: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMC5 Gene

Orthologs for PSMC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMC5 35
  • 99.75 (n)
  • 100 (a)
PSMC5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSMC5 35
  • 91.79 (n)
  • 100 (a)
PSMC5 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMC5 35
  • 91.87 (n)
  • 100 (a)
PSMC5 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmc5 35
  • 90.23 (n)
  • 100 (a)
Psmc5 16
Psmc5 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PSMC5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmc5 35
  • 90.15 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves PSMC5 35
  • 83 (n)
  • 98.03 (a)
PSMC5 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMC5 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75584 35
psmc5 35
  • 80.3 (n)
  • 97.04 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8981 35
zebrafish
(Danio rerio)
Actinopterygii psmc5 35
  • 81.69 (n)
  • 98.03 (a)
psmc5 36
  • 98 (a)
OneToOne
wufa14g02 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007243 35
  • 76.07 (n)
  • 94.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pros45 35
  • 77.78 (n)
  • 93.23 (a)
Pros45 36
  • 92 (a)
OneToMany
Rpt6R 36
  • 87 (a)
OneToMany
Pros45 37
  • 92 (a)
CG2241 37
  • 87 (a)
worm
(Caenorhabditis elegans)
Secernentea F56F11.4 36
  • 74 (a)
OneToMany
rpt-6 35
  • 70.49 (n)
  • 84.79 (a)
rpt-6 36
  • 82 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL043C 35
  • 69.67 (n)
  • 77.89 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPT6 35
  • 65.04 (n)
  • 76.61 (a)
RPT6 36
  • 74 (a)
OneToOne
RPT6 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04752g 35
  • 64.61 (n)
  • 77.12 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6909 35
soybean
(Glycine max)
eudicotyledons Gma.11232 35
thale cress
(Arabidopsis thaliana)
eudicotyledons RPT6A 35
  • 70.31 (n)
  • 82.95 (a)
corn
(Zea mays)
Liliopsida Zm.5322 35
rice
(Oryza sativa)
Liliopsida Os.317 35
Os02g0205300 35
  • 69.8 (n)
  • 82.7 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.27536 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05363 35
  • 67.78 (n)
  • 79.12 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpt6 35
  • 66.93 (n)
  • 81.3 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15364 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5616 36
  • 97 (a)
OneToOne
Species with no ortholog for PSMC5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMC5 Gene

ENSEMBL:
Gene Tree for PSMC5 (if available)
TreeFam:
Gene Tree for PSMC5 (if available)

Paralogs for PSMC5 Gene

Pseudogenes.org Pseudogenes for PSMC5 Gene

genes like me logo Genes that share paralogs with PSMC5: view

No data available for Paralogs for PSMC5 Gene

Variants for PSMC5 Gene

Sequence variations from dbSNP and Humsavar for PSMC5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs13030 -- 63,831,196(+) CAGCT(C/T)GACGG reference, synonymous-codon
rs968719 -- 63,830,911(-) TACCA(A/G)TTCAG reference, synonymous-codon
rs1050708 -- 63,831,152(+) GAGGG(A/G)ACAGT missense, reference
rs1050740 -- 63,831,356(+) GATAT(C/G)CTGGA reference, missense
rs1802130 -- 63,830,362(+) ACTGA(A/T)GATGG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for PSMC5 Gene

Variant ID Type Subtype PubMed ID
nsv833510 CNV Loss 17160897
nsv510720 CNV Loss 20534489
nsv517272 CNV Gain+Loss 19592680

Relevant External Links for PSMC5 Gene

HapMap Linkage Disequilibrium report
PSMC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMC5 Gene

Disorders for PSMC5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for PSMC5 Gene including...

Search for PSMC5 Gene in MalaCards »

(1) University of Copenhagen DISEASES for PSMC5 Gene

genes like me logo Genes that share disorders with PSMC5: view

No data available for UniProtKB/Swiss-Prot for PSMC5 Gene

Publications for PSMC5 Gene

  1. Localization of genes encoding two human one-domain members of the AAA family: PSMC5 (the thyroid hormone receptor-interacting protein, TRIP1) and PSMC3 (the Tat-binding protein, TBP1). (PMID: 9048938) Hoyle J. … Fisher E.M. (Hum. Genet. 1997) 2 3 23
  2. Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N. … Tanaka K. (Biochem. Biophys. Res. Commun. 1998) 2 3 23
  3. Simultaneous binding of PA28 and PA700 activators to 20 S proteasomes. (PMID: 9620878) Hendil K.B. … Tanaka K. (Biochem. J. 1998) 3 23
  4. Proteasome-mediated degradation of the vitamin D receptor (VDR) and a putative role for SUG1 interaction with the AF-2 domain of VDR. (PMID: 9831079) Masuyama H. … MacDonald P.N. (J. Cell. Biochem. 1998) 3 23
  5. The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor. (PMID: 9173976) Weeda G. … Egly J.M. (Nucleic Acids Res. 1997) 3 23

Products for PSMC5 Gene

  • Addgene plasmids for PSMC5

Sources for PSMC5 Gene

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