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Aliases for PSMC5 Gene

Aliases for PSMC5 Gene

  • Proteasome 26S Subunit, ATPase 5 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 2 3
  • Thyroid Hormone Receptor-Interacting Protein 1 3 4
  • 26S Proteasome AAA-ATPase Subunit RPT6 3 4
  • Proteasome Subunit P45 3 4
  • P45/SUG 3 4
  • TRIP1 3 4
  • SUG1 3 4
  • 26S Protease Regulatory Subunit 8 3
  • Testicular Tissue Protein Li 149 3
  • Proteasome 26S ATPase Subunit 5 3
  • Proteasome 26S Subunit ATPase 5 4
  • Tat-Binding Protein Homolog 10 3
  • Thyroid Receptor Interactor 1 3
  • MSUG1 Protein 3
  • SUG-1 3
  • TBP10 3
  • P45 3
  • S8 3

External Ids for PSMC5 Gene

Previous GeneCards Identifiers for PSMC5 Gene

  • GC17P061555
  • GC17P064331
  • GC17P062245
  • GC17P062378
  • GC17P059258
  • GC17P061904
  • GC17P057272

Summaries for PSMC5 Gene

Entrez Gene Summary for PSMC5 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for PSMC5 Gene

PSMC5 (Proteasome 26S Subunit, ATPase 5) is a Protein Coding gene. Among its related pathways are RET signaling and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include receptor binding and transcription factor binding.

UniProtKB/Swiss-Prot for PSMC5 Gene

  • The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

Gene Wiki entry for PSMC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMC5 Gene

Genomics for PSMC5 Gene

Regulatory Elements for PSMC5 Gene

Enhancers for PSMC5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F063783 0.5 ENCODE 12 -41.0 -41011 4.3 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 FTSJ3 DDX42 PSMC5 ENSG00000125695 STRADA CEP95 MAP3K3 PIR56411 CCDC47
GH17F063751 1 Ensembl ENCODE 11.6 -75.1 -75058 1.0 ZNF664 GATA3 MAX ETV6 MYC TCF7L2 FTSJ3 PSMC5 ENSG00000125695 STRADA
GH17F063752 0.2 ENCODE 11.6 -74.3 -74257 0.2 SIX4 MTA2 YBX1 DPF2 GATAD2B ZNF217 CTBP1 JUND GATA3 RCOR1 PSMC5 FTSJ3 ENSG00000125695 GC17P063754
GH17F063760 0.9 Ensembl ENCODE 11.3 -65.4 -65367 1.6 ZNF493 ZFP64 ZNF155 ZNF121 ZNF366 ZNF302 ZNF354C ZNF138 EGR2 PAF1 CEP95 DDX42 POLG2 MIR3064 PSMC5 FTSJ3 LIMD2 SMARCD2 EEF1DP7 GC17P063754
GH17F063694 0.5 ENCODE 11 -127.9 -127881 10.2 HDGF PKNOX1 WRNIP1 SIN3A ARID4B ZNF48 GLIS2 ELK1 ZNF143 PAF1 FTSJ3 CSH2 STRADA ENSG00000125695 PSMC5 TCAM1P GC17M063698 GC17M063699 PIR54058
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PSMC5 on UCSC Golden Path with GeneCards custom track

Promoters for PSMC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001350990 248 2401 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207

Transcription factor binding sites by QIAGEN in the PSMC5 gene promoter:

Genomic Location for PSMC5 Gene

Chromosome:
17
Start:
63,827,152 bp from pter
End:
63,832,027 bp from pter
Size:
4,876 bases
Orientation:
Plus strand

Genomic View for PSMC5 Gene

Genes around PSMC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMC5 Gene

Proteins for PSMC5 Gene

  • Protein details for PSMC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62195-PRS8_HUMAN
    Recommended name:
    26S protease regulatory subunit 8
    Protein Accession:
    P62195
    Secondary Accessions:
    • A8K3Z3
    • A8K763
    • O35051
    • O43208
    • P47210
    • P52915
    • P52916

    Protein attributes for PSMC5 Gene

    Size:
    406 amino acids
    Molecular mass:
    45626 Da
    Quaternary structure:
    • Component of a complex with USP49 and RUVBL1. Interacts with PRPF19. Interacts with TRIM5. Interacts with NDC80. Interacts with PAAF1. Interacts, in vitro, with the thyroid hormone receptor (in a thyroid hormone T3-dependent manner) and with retinoid X receptor (RXR).

    Three dimensional structures from OCA and Proteopedia for PSMC5 Gene

    Alternative splice isoforms for PSMC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMC5 Gene

Post-translational modifications for PSMC5 Gene

  • Ubiquitination at Lys 27, Lys 38, Lys 88, Lys 94, Lys 101, Lys 125, Lys 130, Lys 142, Lys 170, Lys 196, Lys 330, and Lys 397
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSMC5 (RPT6)
  • Abcam antibodies for PSMC5

No data available for DME Specific Peptides for PSMC5 Gene

Domains & Families for PSMC5 Gene

Gene Families for PSMC5 Gene

Suggested Antigen Peptide Sequences for PSMC5 Gene

Graphical View of Domain Structure for InterPro Entry

P62195

UniProtKB/Swiss-Prot:

PRS8_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with PSMC5: view

Function for PSMC5 Gene

Molecular function for PSMC5 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (proteasome,macropain,26S) 19/22S regulator of proteasome ,ATPase subunit,46kDa
UniProtKB/Swiss-Prot Function:
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

Gene Ontology (GO) - Molecular Function for PSMC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003712 transcription cofactor activity TAS 7870181
GO:0005102 receptor binding IEA --
GO:0005515 protein binding IPI 9173976
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PSMC5: view
genes like me logo Genes that share phenotypes with PSMC5: view

Animal Model Products

miRNA for PSMC5 Gene

Transcription Factor Targets for PSMC5 Gene

Selected GeneGlobe predicted Target genes for PSMC5

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PSMC5

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for PSMC5 Gene

Localization for PSMC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMC5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMC5 Gene COMPARTMENTS Subcellular localization image for PSMC5 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
peroxisome 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PSMC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA,IDA 9464850
GO:0005634 nucleus IEA,IDA 9927201
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 9927201
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMC5: view

Pathways & Interactions for PSMC5 Gene

SuperPathways for PSMC5 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
.78
.32
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMC5: view

Gene Ontology (GO) - Biological Process for PSMC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS 7870181
genes like me logo Genes that share ontologies with PSMC5: view

No data available for SIGNOR curated interactions for PSMC5 Gene

Drugs & Compounds for PSMC5 Gene

(3) Drugs for PSMC5 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 794
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0

(2) Additional Compounds for PSMC5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PSMC5: view

Transcripts for PSMC5 Gene

Unigene Clusters for PSMC5 Gene

Proteasome (prosome, macropain) 26S subunit, ATPase, 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PSMC5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMC5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - - - - - -
SP7: -
SP8: - - -
SP9: - -
SP10: -
SP11: - -
SP12: -
SP13: -
SP14:

ExUns: 10c ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PSMC5 Gene

GeneLoc Exon Structure for
PSMC5
ECgene alternative splicing isoforms for
PSMC5

Expression for PSMC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMC5 Gene

Protein differential expression in normal tissues from HIPED for PSMC5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMC5 Gene



Protein tissue co-expression partners for PSMC5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMC5 Gene:

PSMC5

SOURCE GeneReport for Unigene cluster for PSMC5 Gene:

Hs.79387
genes like me logo Genes that share expression patterns with PSMC5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMC5 Gene

Orthologs for PSMC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMC5 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia PSMC5 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSMC5 34 35
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia PSMC5 34 35
  • 91.87 (n)
cow
(Bos Taurus)
Mammalia PSMC5 34 35
  • 91.79 (n)
mouse
(Mus musculus)
Mammalia Psmc5 34 16 35
  • 90.23 (n)
rat
(Rattus norvegicus)
Mammalia Psmc5 34
  • 90.15 (n)
chicken
(Gallus gallus)
Aves PSMC5 34 35
  • 83 (n)
lizard
(Anolis carolinensis)
Reptilia PSMC5 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmc5 34
  • 80.3 (n)
MGC75584 34
zebrafish
(Danio rerio)
Actinopterygii psmc5 34 35
  • 81.69 (n)
wufa14g02 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8981 34
fruit fly
(Drosophila melanogaster)
Insecta CG2241 36
  • 87 (a)
Rpt6R 35
  • 87 (a)
OneToMany
Pros45 36 34 35
  • 77.78 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007243 34
  • 76.07 (n)
worm
(Caenorhabditis elegans)
Secernentea F56F11.4 35
  • 74 (a)
OneToMany
rpt-6 34 35
  • 70.49 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL043C 34
  • 69.67 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPT6 34 35 37
  • 65.04 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04752g 34
  • 64.61 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RPT6A 34
  • 70.31 (n)
soybean
(Glycine max)
eudicotyledons Gma.11232 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6909 34
rice
(Oryza sativa)
Liliopsida Os02g0205300 34
  • 69.8 (n)
Os.317 34
wheat
(Triticum aestivum)
Liliopsida Ta.27536 34
corn
(Zea mays)
Liliopsida Zm.5322 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5616 35
  • 97 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU05363 34
  • 67.78 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpt6 34
  • 66.93 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15364 34
Species where no ortholog for PSMC5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMC5 Gene

ENSEMBL:
Gene Tree for PSMC5 (if available)
TreeFam:
Gene Tree for PSMC5 (if available)

Paralogs for PSMC5 Gene

No data available for Paralogs for PSMC5 Gene

Variants for PSMC5 Gene

Sequence variations from dbSNP and Humsavar for PSMC5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_035901 A colorectal cancer sample
rs1048636 -- 63,832,243(+) TACCT(C/T)AGGCC downstream-variant-500B, utr-variant-3-prime
rs1048644 -- 63,832,123(+) TGCCA(A/G)AAGTG downstream-variant-500B, utr-variant-3-prime
rs1050708 -- 63,831,152(+) GAGGG(A/G)ACAGT nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1050740 -- 63,831,356(+) GATAT(C/G)CTGGA nc-transcript-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PSMC5 Gene

Variant ID Type Subtype PubMed ID
nsv510720 CNV deletion 20534489
nsv517272 CNV gain+loss 19592680
nsv833510 CNV loss 17160897

Variation tolerance for PSMC5 Gene

Residual Variation Intolerance Score: 21.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMC5 Gene

Disorders for PSMC5 Gene

Relevant External Links for PSMC5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMC5

No disorders were found for PSMC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMC5 Gene

Publications for PSMC5 Gene

  1. Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N. … Tanaka K. (Biochem. Biophys. Res. Commun. 1998) 2 3 22 64
  2. Localization of genes encoding two human one-domain members of the AAA family: PSMC5 (the thyroid hormone receptor-interacting protein, TRIP1) and PSMC3 (the Tat-binding protein, TBP1). (PMID: 9048938) Hoyle J. … Fisher E.M. (Hum. Genet. 1997) 2 3 22 64
  3. USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. (PMID: 23824326) Zhang Z. … Wang H. (Genes Dev. 2013) 3 4 64
  4. TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions. (PMID: 22078707) Lukic Z. … Campbell E.M. (Retrovirology 2011) 3 4 64
  5. Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death. (PMID: 20085538) Kumar Y. … Swarup G. (Biochem. J. 2010) 3 22 64

Products for PSMC5 Gene

Sources for PSMC5 Gene

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