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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PSMC5 Gene

protein-coding   GIFtS: 68
GCID: GC17P061904

Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5

Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 51 2     S82
TRIP12 3 5     SUG-12
Proteasome 26S Subunit ATPase 52 3     TBP102
Proteasome Subunit P452 3     MSUG1 Protein2
Thyroid Hormone Receptor-Interacting Protein 12 3     p452
26S Proteasome AAA-ATPase Subunit RPT62 3     Proteasome 26S ATPase Subunit 52
SUG12 3     Tat-Binding Protein Homolog 102
p45/SUG2 3     Thyroid Receptor Interactor 12
26S Protease Regulatory Subunit 82     

External Ids:    HGNC: 95521   Entrez Gene: 57052   Ensembl: ENSG000000871917   OMIM: 6016815   UniProtKB: P621953   

Export aliases for PSMC5 gene to outside databases

Previous GC identifers: GC17P061555 GC17P064331 GC17P062245 GC17P062378 GC17P059258 GC17P057272


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PSMC5 Gene:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes,
a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are
composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a
base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in
an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome,
the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a
member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in
proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to
interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Nov 2010)

GeneCards Summary for PSMC5 Gene: 
PSMC5 (proteasome (prosome, macropain) 26S subunit, ATPase, 5) is a protein-coding gene. Diseases associated with PSMC5 include mulibrey nanism, and thyroiditis, and among its related super-pathways are Regulation of APC/C activators between G1/S and early anaphase and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. GO annotations related to this gene include transcription cofactor activity and transcription factor binding.

UniProtKB/Swiss-Prot: PRS8_HUMAN, P62195
Function: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory
(or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex

Gene Wiki entry for PSMC5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PSMC5 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSMC5 promoter sequence
   Search SABiosciences Chromatin IP Primers for PSMC5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSMC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.3   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q23.3

PSMC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMC5 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P061904:  view genomic region     (about GC identifiers)

Start:
61,904,512 bp from pter      End:
61,909,387 bp from pter
Size:
4,876 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PRS8_HUMAN, P62195 (See protein sequence)
Recommended Name: 26S protease regulatory subunit 8  
Size: 406 amino acids; 45626 Da
Subunit: Interacts, in vitro, with the thyroid hormone receptor (in a thyroid hormone T3-dependent manner) and
with retinoid X receptor (RXR) (By similarity). Interacts with NDC80. Interacts with PAAF1. Interacts with TRIM5
Subcellular location: Cytoplasm (Potential). Nucleus (Potential)
2 PDB 3D structures from and Proteopedia for PSMC5:
2KRK (3D)        3KW6 (3D)    
Secondary accessions: A8K3Z3 A8K763 O35051 O43208 P47210 P52915 P52916
Alternative splicing: 2 isoforms:  P62195-1   P62195-2   

Explore the universe of human proteins at neXtProt for PSMC5: NX_P62195

Explore proteomics data for PSMC5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62195

  • PSMC5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PSMC5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001186092.1  NP_002796.4  

    ENSEMBL proteins: 
     ENSP00000464405   ENSP00000310572   ENSP00000463549   ENSP00000463801   ENSP00000462098  
     ENSP00000464602   ENSP00000462495   ENSP00000464646   ENSP00000463107   ENSP00000463938  
     ENSP00000464347   ENSP00000364970  
    Reactome Protein details: P62195
    Human Recombinant Protein Products for PSMC5: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PSMC5 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex IDA9464850
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    PSMC5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    AATP: ATPases / AAA-type
    PSM: Proteasome (prosome, macropain) subunits

    5 InterPro protein domains:
     IPR003959 ATPase_AAA_core
     IPR003960 ATPase_AAA_CS
     IPR027417 P-loop_NTPase
     IPR005937 26S_Psome_P45
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry P62195

    ProtoNet protein and cluster: P62195

    1 Blocks protein domain: IPB011072 Protein kinase PKN/PRK1

    UniProtKB/Swiss-Prot: PRS8_HUMAN, P62195
    Similarity: Belongs to the AAA ATPase family


    PSMC5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRS8_HUMAN, P62195
    Function: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory
    (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex

         Genatlas biochemistry entry for PSMC5:
    multicatalytic proteinase complex (proteasome,macropain,26S) 19/22S regulator of proteasome ,ATPase subunit,46kDa

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003712transcription cofactor activity TAS7870181
    GO:0005102receptor binding ----
    GO:0005515protein binding IPI16189514
    GO:0005524ATP binding IEA--
         
    PSMC5 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for PSMC5:
     Decreased viability of wild-ty  G0/1 arrest  Increased G1 DNA content  Increased cell death in breast 
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PSMC5 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PSMC5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PSMC5 

    10/619 SABiosciences Target genes for PSMC5 (see all 619):
    ABCD3 ACVR1C ACVR2A ADAMTS2 ADAMTSL2 ADH4 ADH5 ADNP2 AFF2 AGAP11

    miRNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PSMC5 About   (see all 32)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    APC/C:Cdc20 mediated degradation of mitotic proteins0.94
    Removal of licensing factors from origins0.89
    Cdc20:Phospho-APC/C mediated degradation of Cyclin A0.94
    Regulation of DNA replication0.89
    CDK-mediated phosphorylation and removal of Cdc60.94
    Cyclin E associated events during G1/S transition 0.89
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    Switching of origins to a post-replicative state0.89
    2Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    4Chks in Checkpoint Regulation
    Chks in Checkpoint Regulation0.59
    SREBP Proteolysis0.43
    G2-M Phase Transition0.59
    DNA Repair Mechanisms0.32
    Estrogen-mediated S-Phase Entry0.55
    5Metabolism of mRNA
    Metabolism of RNA0.92
    Metabolism of mRNA0.92

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for PSMC5
        Immune response Antigen presentation by MHC class I
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

    5/19 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PSMC5 (see all 19)
        Remodeling of Adherens Junctions
    CDK5 Pathway
    Estrogen-mediated S-Phase Entry
    G2-M Phase Transition
    DNA Repair Mechanisms

    3 GeneGo (Thomson Reuters) Pathways for PSMC5
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Antigen presentation by MHC class I

    2 BioSystems Pathways for PSMC5
        Parkin-Ubiquitin Proteasomal System pathway
    Proteasome Degradation


    5/74        Reactome Pathways for PSMC5 (see all 74)
        Orc1 removal from chromatin
    CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway
    CDT1 association with the CDC6:ORC:origin complex
    Autodegradation of the E3 ubiquitin ligase COP1


    2         Kegg Pathways  (Kegg details for PSMC5):
        Proteasome
    Epstein-Barr virus infection


    PSMC5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PSMC5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1046 Interacting proteins for PSMC5 (P621951, 2, 3 ENSP000003105724) via UniProtKB, MINT, STRING, and/or I2D (see all 1046)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/30 biological process terms (GO ID links to tree view) (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--

    PSMC5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PSMC5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PSMC5 (PRS8)

    1 HMDB Compound for PSMC5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Thyrotropin-releasing factorProtirelin (see all 36)24305-27-9--

    3 Novoseek inferred chemical compound relationships for PSMC5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin d 28.8 2 14702340 (1), 9831079 (1)
    retinoic acid 15.4 1 10094499 (1)
    steroid 11.7 3 9280066 (1), 9513710 (1), 15234273 (1)

    Search CenterWatch for drugs/clinical trials and news about PSMC5 / PRS8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PSMC5 gene (2 alternative transcripts): 
    NM_001199163.1  NM_002805.5  

    Unigene Cluster for PSMC5:

    Proteasome (prosome, macropain) 26S subunit, ATPase, 5
    Hs.79387  [show with all ESTs]
    Unigene Representative Sequence: NM_001199163
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000579708 ENST00000310144(uc002jcb.3) ENST00000582420 ENST00000581842
    ENST00000582130 ENST00000584320 ENST00000583283 ENST00000581764 ENST00000585123
    ENST00000579147(uc010ddy.3) ENST00000580864(uc002jcd.3) ENST00000584536
    ENST00000585242 ENST00000578570 ENST00000580265 ENST00000581882 ENST00000579031
    ENST00000584880
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK290758.1 AK291878.1 BC001932.1 BC002367.2 BC127888.1 D44467.1 L38810.1 

    24/31 DOTS entries (see all 31):

    DT.92474818  DT.99926666  DT.100868508  DT.318232  DT.100745357  DT.100756779  DT.92474824  DT.100745401 
    DT.100745417  DT.92474856  DT.102838780  DT.75120849  DT.95332113  DT.91723560  DT.100745437  DT.102843979 
    DT.121007197  DT.92474841  DT.95291584  DT.121007467  DT.92474941  DT.97855567  DT.121007409  DT.121007580 

    24/673 AceView cDNA sequences (see all 673):

    BM794596 CR626071 BQ214128 BQ669474 BG252593 BP338586 CA487577 AW247722 
    BP382083 BM850551 BG386946 BX458700 BQ668409 CD245380 BQ880018 BU726346 
    AI568349 BQ674358 BU146859 BM785471 BQ066209 BI753601 BU160327 CR623587 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for PSMC5 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ·
    SP1:                          -     -     -     -     -     -           -                 -           -     -                       -                 -         
    SP2:                          -     -     -     -     -     -                             -           -     -                       -                 -         
    SP3:                          -     -     -     -     -     -           -                 -           -     -     -                 -                 -         
    SP4:                                                        -           -                 -           -     -                       -                           
    SP5:                                                                    -                 -           -     -                       -                           

    ExUns: 10c ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for PSMC5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PSMC5 expression in normal human tissues (normalized intensities)      PSMC5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCATCAAGA
    PSMC5 Expression
    About this image


    PSMC5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   

    See PSMC5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PSMC5

    SOURCE GeneReport for Unigene cluster: Hs.79387
        SABiosciences Expression via Pathway-Focused PCR Array including PSMC5: 
              Nuclear Receptors & Coregulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PSMC5 gene from 10/28 species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Psmc51 , 5 protease (prosome, macropain) 26S subunit, ATPase 51, 5 90.23(n)1
    100(a)1
      11 (68.89 cM)5
    191841  NM_008950.11  NP_032976.11 
     1062561545 
    chicken
    (Gallus gallus)
    Aves PSMC51 proteasome (prosome, macropain) 26S subunit, ATPase, more 83.09(n)
    98.28(a)
      428274  XM_425834.3  XP_425834.3 
    lizard
    (Anolis carolinensis)
    Reptilia PSMC56
    Uncharacterized protein
    86(a)
    1 ↔ 1
    6(71630181-71680265)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC045221.12   -- 82.08(n)    BC045221.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa14g022 Transcribed sequence with moderate similarity to protein more 80.45(n)    CA470973.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pros451 , 3 proteolysis and peptidolysis proteasome
    endopeptidase3
    26S proteasome regulatory subunit 81
    92(a)
    (best of 2)3
    77.78(n)1
    93.23(a)1
      19F43
    331051  NM_134603.11  NP_608447.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rpt-61 Protein RPT-6 70.49(n)
    84.79(a)
      176661  NM_067208.3  NP_499609.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPT6(YGL048C)4
    RPT61
    One of six ATPases of the 19S regulatory particle of more4
    Rpt6p1
    65.04(n)1
    76.61(a)1
      7(411286-410069)4
    8528341, 4  NP_011467.11, 4 
    soybean
    (Glycine max)
    eudicotyledons Gma.112322 Transcribed sequence with strong similarity to protein more 75.87(n)  
    rice
    (Oryza sativa)
    Liliopsida Os.3172 Oryza sativa (japonica cultivar-group) OsRPT6 mRNA more 74.25(n)    AB052887.1 


    ENSEMBL Gene Tree for PSMC5 (if available)
    TreeFam Gene Tree for PSMC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PSMC5 gene
    18/24 SIMAP similar genes for PSMC5 using alignment to 9 protein entries:     PRS8_HUMAN (see all proteins) (see all similar genes):
    PSMC1    PSMC6    DKFZp666D103    PEX6    PSMC2    AFG3L2
    DKFZp667C165    SPG7    ATAD2B    YME1L1    KATNAL2    PSMC4
    PSMC3    ATAD2    DKFZp434K0126    FTSH    VCP    PEX1

    PSMC5 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PSMC5
    PGOHUM00000234948 PGOHUM00000233165


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/84 SNPs in PSMC5 are shown (see all 84)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359014
    A colorectal cancer sample4--see VAR_0359012 R Q mis40--------
    rs1415818101,2
    C--61904338(+) AGATT-/CCACTT
    CCAGTTTC
    CCACT
    2 -- us2k10--------
    rs1451686221,2
    --61907064(+) TTTCCG/TGAGCC 2 -- int10--------
    rs1509519911,2
    C--61907094(+) TACATA/GAATTT 2 -- int10--------
    rs1839222461,2
    --61907130(+) AGTGAC/TGCTTA 2 -- int10--------
    rs1410556311,2
    C--61907171(+) CTCCAA/GAGGAG 2 -- int10--------
    rs1155445921,2
    C,F--61907195(+) ACTGTG/ATCTGT 2 -- int11Minor allele frequency- A:0.03WA 118
    rs2017338141,2
    --61907297(+) AAGAAA/GGTGTT 4 K syn10--------
    rs286071001,2
    C,F--61907318(+) AAAGCA/GGCATG 2 -- int13Minor allele frequency- G:0.01WA EU 1443
    rs1883476061,2
    C--61907354(+) CTGCAG/TTCCCA 2 -- int10--------

    HapMap Linkage Disequilibrium report for PSMC5 (61904512 - 61909387 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PSMC5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833510CNV Loss17160897
    nsv510720CNV Loss20534489
    nsv517272CNV Gain+Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601681    OMIM disorders: --

    8 diseases for PSMC5:    About MalaCards
    mulibrey nanism    thyroiditis    huntington's disease    parkinson's disease
    tuberculosis    neuroblastoma    hepatocellular carcinoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for PSMC5:
    Indolent systemic mastocytosis

    PSMC5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for PSMC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PSMC5 gene, integrated from 9 sources (see all 187):
    (articles sorted by number of sources associating them with PSMC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Localization of genes encoding two human one-domain members of the AAA family: PSMC5 (the thyroid hormone receptor-interacting protein, TRIP1) and PSMC3 (the Tat-binding protein, TBP1). (PubMed id 9048938)1, 3, 9 Hoyle J....Fisher E.M. (1997)
    2. Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PubMed id 9473509)1, 3, 9 Tanahashi N....Tanaka K. (1998)
    3. TRIM5a associates with proteasomal subunits in cells w hile in complex with HIV-1 virions. (PubMed id 22078707)1, 2 Lukic Z....Campbell E.M. (2011)
    4. Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. (PubMed id 15831487)1, 2 Park Y.... Yoon J.-B. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins. (PubMed id 10409732)1, 2 Zheng L.... Lee W.-H. (1999)
    8. HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins. (PubMed id 9295362)1, 2 Chen Y.... Lee W.-H. (1997)
    9. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 2 Yu W.... Gibbs R.A. (1997)
    10. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)1, 2 Lee J.W....Moore D.D. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5705 HGNC: 9552 AceView: PSMC5 Ensembl:ENSG00000087191 euGenes: HUgn5705
    ECgene: PSMC5 Kegg: 5705 H-InvDB: PSMC5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PSMC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PSMC5 gene:
    Search GeneIP for patents involving PSMC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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