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Aliases for PSMC5 Gene

Aliases for PSMC5 Gene

  • Proteasome 26S Subunit, ATPase 5 2 3
  • Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 2 3
  • Thyroid Hormone Receptor-Interacting Protein 1 3 4
  • 26S Proteasome AAA-ATPase Subunit RPT6 3 4
  • Proteasome 26S Subunit ATPase 5 3 4
  • Proteasome Subunit P45 3 4
  • P45/SUG 3 4
  • TRIP1 3 4
  • SUG1 3 4
  • Proteasome 26S ATPase Subunit 5 3
  • Tat-Binding Protein Homolog 10 3
  • Thyroid Receptor Interactor 1 3
  • MSUG1 Protein 3
  • SUG-1 3
  • TBP10 3
  • P45 3
  • S8 3

External Ids for PSMC5 Gene

Previous GeneCards Identifiers for PSMC5 Gene

  • GC17P061555
  • GC17P064331
  • GC17P062245
  • GC17P062378
  • GC17P059258
  • GC17P061904
  • GC17P057272

Summaries for PSMC5 Gene

Entrez Gene Summary for PSMC5 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for PSMC5 Gene

PSMC5 (Proteasome 26S Subunit, ATPase 5) is a Protein Coding gene. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include receptor binding and transcription factor binding.

UniProtKB/Swiss-Prot for PSMC5 Gene

  • The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex

Gene Wiki entry for PSMC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMC5 Gene

Genomics for PSMC5 Gene

Regulatory Elements for PSMC5 Gene

Transcription factor binding sites by QIAGEN in the PSMC5 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PSMC5 Gene

Chromosome:
17
Start:
63,827,152 bp from pter
End:
63,832,027 bp from pter
Size:
4,876 bases
Orientation:
Plus strand

Genomic View for PSMC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSMC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMC5 Gene

Proteins for PSMC5 Gene

  • Protein details for PSMC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62195-PRS8_HUMAN
    Recommended name:
    26S protease regulatory subunit 8
    Protein Accession:
    P62195
    Secondary Accessions:
    • A8K3Z3
    • A8K763
    • O35051
    • O43208
    • P47210
    • P52915
    • P52916

    Protein attributes for PSMC5 Gene

    Size:
    406 amino acids
    Molecular mass:
    45626 Da
    Quaternary structure:
    • Component of a complex with USP49 and RUVBL1. Interacts with PRPF19. Interacts with TRIM5. Interacts with NDC80. Interacts with PAAF1. Interacts, in vitro, with the thyroid hormone receptor (in a thyroid hormone T3-dependent manner) and with retinoid X receptor (RXR).

    Three dimensional structures from OCA and Proteopedia for PSMC5 Gene

    Alternative splice isoforms for PSMC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMC5 Gene

Proteomics data for PSMC5 Gene at MOPED

Post-translational modifications for PSMC5 Gene

  • Ubiquitination at Lys 27, Lys 38, Lys 88, Lys 94, Lys 101, Lys 125, Lys 130, Lys 142, Lys 170, Lys 196, Lys 330, and Lys 397
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSMC5 (RPT6)

No data available for DME Specific Peptides for PSMC5 Gene

Domains & Families for PSMC5 Gene

Suggested Antigen Peptide Sequences for PSMC5 Gene

Graphical View of Domain Structure for InterPro Entry

P62195

UniProtKB/Swiss-Prot:

PRS8_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with PSMC5: view

Function for PSMC5 Gene

Molecular function for PSMC5 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (proteasome,macropain,26S) 19/22S regulator of proteasome ,ATPase subunit,46kDa
UniProtKB/Swiss-Prot Function:
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex

Gene Ontology (GO) - Molecular Function for PSMC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity TAS 7870181
GO:0005102 receptor binding --
GO:0005515 protein binding IPI 9173976
GO:0005524 ATP binding IEA --
GO:0008134 transcription factor binding IPI 9173976
genes like me logo Genes that share ontologies with PSMC5: view
genes like me logo Genes that share phenotypes with PSMC5: view

Animal Model Products

CRISPR Products

miRNA for PSMC5 Gene

Transcription Factor Targets for PSMC5 Gene

Selected GeneGlobe predicted Target genes for PSMC5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMC5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models and HOMER Transcription for PSMC5 Gene

Localization for PSMC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMC5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMC5 Gene COMPARTMENTS Subcellular localization image for PSMC5 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PSMC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 9464850
GO:0005634 nucleus IDA 9927201
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 9927201
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMC5: view

Pathways & Interactions for PSMC5 Gene

SuperPathways for PSMC5 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin receptor SHC signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.53
5 Immune System
genes like me logo Genes that share pathways with PSMC5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PSMC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with PSMC5: view

No data available for SIGNOR curated interactions for PSMC5 Gene

Drugs & Compounds for PSMC5 Gene

(3) Drugs for PSMC5 Gene - From: DGIdb and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 758
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
vitamin d Pharma 1463

(2) Additional Compounds for PSMC5 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
retinoic acid
302-79-4
Steroid
genes like me logo Genes that share compounds with PSMC5: view

Transcripts for PSMC5 Gene

Unigene Clusters for PSMC5 Gene

Proteasome (prosome, macropain) 26S subunit, ATPase, 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMC5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMC5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - - - - - -
SP7: -
SP8: - - -
SP9: - -
SP10: -
SP11: - -
SP12: -
SP13: -
SP14:

ExUns: 10c ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PSMC5 Gene

GeneLoc Exon Structure for
PSMC5
ECgene alternative splicing isoforms for
PSMC5

Expression for PSMC5 Gene

mRNA expression in normal human tissues for PSMC5 Gene

Protein differential expression in normal tissues from HIPED for PSMC5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMC5 Gene



SOURCE GeneReport for Unigene cluster for PSMC5 Gene Hs.79387

genes like me logo Genes that share expression patterns with PSMC5: view

Protein tissue co-expression partners for PSMC5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMC5 Gene

Orthologs for PSMC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMC5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMC5 35
  • 91.79 (n)
  • 100 (a)
PSMC5 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMC5 35
  • 91.87 (n)
  • 100 (a)
PSMC5 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmc5 35
  • 90.23 (n)
  • 100 (a)
Psmc5 16
Psmc5 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSMC5 35
  • 99.75 (n)
  • 100 (a)
PSMC5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmc5 35
  • 90.15 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia PSMC5 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMC5 35
  • 83 (n)
  • 98.03 (a)
PSMC5 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMC5 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75584 35
psmc5 35
  • 80.3 (n)
  • 97.04 (a)
zebrafish
(Danio rerio)
Actinopterygii psmc5 35
  • 81.69 (n)
  • 98.03 (a)
wufa14g02 35
psmc5 36
  • 98 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8981 35
fruit fly
(Drosophila melanogaster)
Insecta CG2241 37
  • 87 (a)
Pros45 37
  • 92 (a)
Pros45 35
  • 77.78 (n)
  • 93.23 (a)
Pros45 36
  • 92 (a)
OneToMany
Rpt6R 36
  • 87 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007243 35
  • 76.07 (n)
  • 94.62 (a)
worm
(Caenorhabditis elegans)
Secernentea rpt-6 35
  • 70.49 (n)
  • 84.79 (a)
F56F11.4 36
  • 74 (a)
OneToMany
rpt-6 36
  • 82 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL043C 35
  • 69.67 (n)
  • 77.89 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04752g 35
  • 64.61 (n)
  • 77.12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPT6 35
  • 65.04 (n)
  • 76.61 (a)
RPT6 36
  • 74 (a)
OneToOne
RPT6 38
thale cress
(Arabidopsis thaliana)
eudicotyledons RPT6A 35
  • 70.31 (n)
  • 82.95 (a)
soybean
(Glycine max)
eudicotyledons Gma.11232 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6909 35
rice
(Oryza sativa)
Liliopsida Os.317 35
Os02g0205300 35
  • 69.8 (n)
  • 82.7 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.27536 35
corn
(Zea mays)
Liliopsida Zm.5322 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15364 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05363 35
  • 67.78 (n)
  • 79.12 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpt6 35
  • 66.93 (n)
  • 81.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5616 36
  • 97 (a)
OneToOne
Species with no ortholog for PSMC5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMC5 Gene

ENSEMBL:
Gene Tree for PSMC5 (if available)
TreeFam:
Gene Tree for PSMC5 (if available)

Paralogs for PSMC5 Gene

Pseudogenes.org Pseudogenes for PSMC5 Gene

genes like me logo Genes that share paralogs with PSMC5: view

No data available for Paralogs for PSMC5 Gene

Variants for PSMC5 Gene

Sequence variations from dbSNP and Humsavar for PSMC5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs13030 -- 63,831,196(+) CAGCT(C/T)GACGG reference, synonymous-codon, nc-transcript-variant
rs968719 -- 63,830,911(-) TACCA(A/G)TTCAG reference, synonymous-codon, nc-transcript-variant
rs1050708 -- 63,831,152(+) GAGGG(A/G)ACAGT missense, reference, nc-transcript-variant
rs1050740 -- 63,831,356(+) GATAT(C/G)CTGGA reference, missense, nc-transcript-variant
rs1802130 -- 63,830,362(+) ACTGA(A/T)GATGG missense, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMC5 Gene

Variant ID Type Subtype PubMed ID
nsv833510 CNV Loss 17160897
nsv510720 CNV Loss 20534489
nsv517272 CNV Gain+Loss 19592680

Variation tolerance for PSMC5 Gene

Residual Variation Intolerance Score: 21.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMC5 Gene

HapMap Linkage Disequilibrium report
PSMC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMC5 Gene

Disorders for PSMC5 Gene

Relevant External Links for PSMC5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMC5
genes like me logo Genes that share disorders with PSMC5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMC5 Gene

Publications for PSMC5 Gene

  1. Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N. … Tanaka K. (Biochem. Biophys. Res. Commun. 1998) 2 23 67
  2. Localization of genes encoding two human one-domain members of the AAA family: PSMC5 (the thyroid hormone receptor-interacting protein, TRIP1) and PSMC3 (the Tat-binding protein, TBP1). (PMID: 9048938) Hoyle J. … Fisher E.M. (Hum. Genet. 1997) 2 23 67
  3. Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death. (PMID: 20085538) Kumar Y. … Swarup G. (Biochem. J. 2010) 23 67
  4. [Microarray analysis of differentially expressed genes in peripheral leucocytes derived from severe preeclampsia and normotensive pregnancies]. (PMID: 19087513) Sun C.J. … Cui M.H. (Zhonghua Fu Chan Ke Za Zhi 2008) 23 67
  5. Inhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisons. (PMID: 16432160) Yamada H.Y. … Gorbsky G.J. (Mol. Cancer Ther. 2006) 23 67

Products for PSMC5 Gene

Sources for PSMC5 Gene

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