Aliases for PSMC4 Gene
External Ids for PSMC4 Gene
Previous HGNC Symbols for PSMC4 Gene
Previous GeneCards Identifiers for PSMC4 Gene
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for PSMC4 Gene
PSMC4 (Proteasome 26S Subunit, ATPase 4) is a Protein Coding gene. Diseases associated with PSMC4 include Cystic Fibrosis and Myotonia. Among its related pathways are RET signaling and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include hydrolase activity and four-way junction helicase activity.
UniProtKB/Swiss-Prot for PSMC4 Gene
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.