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Aliases for PSMC4 Gene

Aliases for PSMC4 Gene

  • Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 2 3
  • Tat-Binding Protein 7 2 3 4
  • TBP7 3 4 6
  • 26S Proteasome AAA-ATPase Subunit RPT3 3 4
  • MB67-Interacting Protein 3 4
  • Protease 26S Subunit 6 2 3
  • MIP224 3 4
  • TBP-7 3 4
  • S6 3 6
  • 26S Protease Regulatory Subunit 6B 3
  • Proteasome 26S Subunit ATPase 4 4
  • MB67 Interacting Protein 2
  • RPT3 3

External Ids for PSMC4 Gene

Previous Symbols for PSMC4 Gene

  • MIP224

Summaries for PSMC4 Gene

Entrez Gene Summary for PSMC4 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMC4 Gene

PSMC4 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4) is a Protein Coding gene. Diseases associated with PSMC4 include episodic ataxia, type 2 and indolent systemic mastocytosis. Among its related pathways are Signaling by GPCR and Downstream Signaling Events Of B Cell Receptor (BCR). GO annotations related to this gene include ATPase activity.

UniProtKB/Swiss-Prot for PSMC4 Gene

  • The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

Gene Wiki entry for PSMC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMC4 Gene

Genomics for PSMC4 Gene

Genomic Location for PSMC4 Gene

Start:
39,971,005 bp from pter
End:
39,981,764 bp from pter
Size:
10,760 bases
Orientation:
Plus strand

Genomic View for PSMC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSMC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMC4 Gene

Regulatory Elements for PSMC4 Gene

Proteins for PSMC4 Gene

  • Protein details for PSMC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43686-PRS6B_HUMAN
    Recommended name:
    26S protease regulatory subunit 6B
    Protein Accession:
    P43686
    Secondary Accessions:
    • Q96FV5
    • Q9UBM3
    • Q9UEX3

    Protein attributes for PSMC4 Gene

    Size:
    418 amino acids
    Molecular mass:
    47366 Da
    Quaternary structure:
    • Interacts with NR1I3. Interacts with PAAF1. Interacts with TRIM5.

    Three dimensional structures from OCA and Proteopedia for PSMC4 Gene

    Alternative splice isoforms for PSMC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMC4 Gene

Proteomics data for PSMC4 Gene at MOPED

Post-translational modifications for PSMC4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys70, Lys125, Lys192, Lys217, Lys238, Lys255, and Lys273

Other Protein References for PSMC4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PSMC4 Gene

Domains for PSMC4 Gene

Gene Families for PSMC4 Gene

HGNC:
  • AATP :ATPases / AAA-type
  • PSM :Proteasome (prosome, macropain) subunits

Protein Domains for PSMC4 Gene

UniProtKB/Swiss-Prot:

PRS6B_HUMAN
Family:
  • Belongs to the AAA ATPase family.:
    • P43686
genes like me logo Genes that share domains with PSMC4: view

Function for PSMC4 Gene

Molecular function for PSMC4 Gene

GENATLAS Biochemistry: multicatalytic proteinase complex (prosome,macropain,26S) 19/22S regulator of proteasome S6,ATPase subunit 4,51.6kDa
UniProtKB/Swiss-Prot Function: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

Gene Ontology (GO) - Molecular Function for PSMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12525503
GO:0005524 ATP binding IEA --
GO:0009378 four-way junction helicase activity --
GO:0016787 hydrolase activity --
GO:0016887 ATPase activity TAS 9473509
genes like me logo Genes that share ontologies with PSMC4: view
genes like me logo Genes that share phenotypes with PSMC4: view

Animal Models for PSMC4 Gene

MGI Knock Outs for PSMC4:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PSMC4 Gene

Localization for PSMC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMC4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMC4 Gene COMPARTMENTS Subcellular localization image for PSMC4 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 4
peroxisome 2

Gene Ontology (GO) - Cellular Components for PSMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 17323924
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMC4: view

Pathways for PSMC4 Gene

SuperPathways for PSMC4 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.38
2 Chks in Checkpoint Regulation
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.62
5 Mitotic Metaphase and Anaphase
genes like me logo Genes that share pathways with PSMC4: view

Gene Ontology (GO) - Biological Process for PSMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0001824 blastocyst development IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with PSMC4: view

Compounds for PSMC4 Gene

(38) Novoseek inferred chemical compound relationships for PSMC4 Gene

Compound -log(P) Hits PubMed IDs
rapamycin 84.6 40
potassium 48.2 12
ly294002 45.9 3
threonine 45.6 1
wortmannin 42.8 2
genes like me logo Genes that share compounds with PSMC4: view

Transcripts for PSMC4 Gene

Unigene Clusters for PSMC4 Gene

Proteasome (prosome, macropain) 26S subunit, ATPase, 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMC4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: - -
SP3:
SP4:
SP5: -
SP6:

Relevant External Links for PSMC4 Gene

GeneLoc Exon Structure for
PSMC4
ECgene alternative splicing isoforms for
PSMC4

Expression for PSMC4 Gene

mRNA expression in normal human tissues for PSMC4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMC4 Gene

SOURCE GeneReport for Unigene cluster for PSMC4 Gene Hs.211594

genes like me logo Genes that share expressions with PSMC4: view

Orthologs for PSMC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMC4 36
  • 99.6 (n)
  • 100 (a)
PSMC4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSMC4 36
  • 92.19 (n)
  • 100 (a)
PSMC4 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMC4 36
  • 91.95 (n)
  • 100 (a)
PSMC4 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmc4 36
  • 91.47 (n)
  • 99.76 (a)
Psmc4 16
Psmc4 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PSMC4 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMC4 37
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmc4 36
  • 91.47 (n)
  • 99.76 (a)
lizard
(Anolis carolinensis)
Reptilia PSMC4 37
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68784 36
tropical clawed frog
(Silurana tropicalis)
Amphibia psmc4 36
  • 81.5 (n)
  • 96.89 (a)
Str.200 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10986 36
zebrafish
(Danio rerio)
Actinopterygii psmc4 36
  • 82.46 (n)
  • 96.65 (a)
psmc4 37
  • 97 (a)
OneToOne
wufe38b10 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003008 36
  • 76.16 (n)
  • 88.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rpt3 36
  • 76.78 (n)
  • 89.05 (a)
Rpt3 37
  • 87 (a)
OneToMany
Rpt3R 37
  • 78 (a)
OneToMany
CG9475 38
  • 78 (a)
Rpt3 38
  • 87 (a)
worm
(Caenorhabditis elegans)
Secernentea rpt-3 36
  • 68.42 (n)
  • 82.89 (a)
rpt-3 37
  • 78 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR394W 36
  • 63.16 (n)
  • 71.32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPT3 36
  • 60.03 (n)
  • 69.9 (a)
RPT3 37
  • 66 (a)
OneToOne
RPT3 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C06534g 36
  • 60.61 (n)
  • 71.32 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7717 36
soybean
(Glycine max)
eudicotyledons Gma.1686 36
thale cress
(Arabidopsis thaliana)
eudicotyledons RPT3 36
  • 68.69 (n)
  • 80.3 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.8287 36
corn
(Zea mays)
Liliopsida Zm.16789 36
rice
(Oryza sativa)
Liliopsida Os.11446 36
Os02g0325100 36
  • 71.87 (n)
  • 83.07 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.21374 36
bread mold
(Neurospora crassa)
Ascomycetes NCU02260 36
  • 67.66 (n)
  • 74.19 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpt3 36
  • 61.67 (n)
  • 75.26 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.118 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7996 37
  • 86 (a)
OneToOne
Species with no ortholog for PSMC4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMC4 Gene

ENSEMBL:
Gene Tree for PSMC4 (if available)
TreeFam:
Gene Tree for PSMC4 (if available)

Paralogs for PSMC4 Gene

Selected SIMAP similar genes for PSMC4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PSMC4: view

No data available for Paralogs for PSMC4 Gene

Variants for PSMC4 Gene

Sequence variations from dbSNP and Humsavar for PSMC4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs186802 -- 39,981,056(+) ttcac(C/T)atgtt intron-variant
rs234339 -- 39,978,142(+) GAATT(C/T)ATCTA intron-variant
rs234340 -- 39,979,323(+) TGGGA(A/G)GCTAA intron-variant
rs234341 -- 39,980,229(+) TTATC(A/G)TGACA intron-variant
rs234342 -- 39,980,264(+) CTGAG(C/T)TGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMC4 Gene

Variant ID Type Subtype PubMed ID
dgv1082e1 CNV Complex 17122850
nsv9726 CNV Gain 18304495

Relevant External Links for PSMC4 Gene

HapMap Linkage Disequilibrium report
PSMC4

Disorders for PSMC4 Gene

(1) University of Copenhagen DISEASES for PSMC4 Gene

(17) Novoseek inferred disease relationships for PSMC4 Gene

Disease -log(P) Hits PubMed IDs
tumors 27.7 13
severe mental retardation 20.7 1
cancer 13.4 1
rhabdomyosarcoma 12 2
epilepsy 6.19 1
genes like me logo Genes that share disorders with PSMC4: view

No data available for UniProtKB/Swiss-Prot for PSMC4 Gene

Publications for PSMC4 Gene

  1. A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily. (PMID: 8603043) Choi H.S. … Moore D.D. (J. Steroid Biochem. Mol. Biol. 1996) 2 3 4 23
  2. Tat-binding protein 7 is a subunit of the 26S protease. (PMID: 8060531) Dubiel W. … Rechsteiner M. (Biol. Chem. Hoppe-Seyler 1994) 3 4 23
  3. Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N. … Tanaka K. (Biochem. Biophys. Res. Commun. 1998) 2 3 23
  4. E3 ubiquitin ligase RNF2 interacts with the S6' proteasomal ATPase subunit and increases the ATP hydrolysis activity of S6'. (PMID: 15773819) Lee S.J. … Kang S. (Biochem. J. 2005) 3 23
  5. The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein--implications for Parkinson's disease. (PMID: 17327361) Marx F.P. … KrA1ger R. (FASEB J. 2007) 3 23

Products for PSMC4 Gene

Sources for PSMC4 Gene

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