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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PSMC4 Gene

protein-coding GIFtS: 65
GCID: GC19P040477

proteasome (prosome, macropain) 26S subunit, ATPase, 4

(Previous symbol: MIP224)

Explore 50 diseases affiliated with
PSMC4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4¹ ²		MGC13687¹
TBP7¹ ² ³ ⁵		MGC23214¹
MIP224¹ ² ³		MGC8570¹
TBP-7¹ ² ³		26S Protease Regulatory Subunit 6B²
S6¹ ² ⁵		RPT3²
26S Proteasome AAA-ATPase Subunit RPT3² ³		Protease 26S Subunit 6²
MB67-Interacting Protein² ³		Proteasome 26S Subunit ATPase 4³
Tat-Binding Protein 7² ³

External Ids:	HGNC: 9551¹	Entrez Gene: 5704²	Ensembl: ENSG00000013275⁷	OMIM: 602707⁵	UniProtKB: P43686³

Export aliases for PSMC4 gene to outside databases

Previous GC identifers: GC19P041104 GC19P040868 GC19P045153 GC19P045168 GC19P036913

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PSMC4:

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a

20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed

of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which

contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits.

Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an

ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of

ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded

protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through

interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed

for this gene. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: PRS6B_HUMAN, P43686

Function: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or

ATPase) complex confers ATP dependency and substrate specificity to the 26S complex

Gene Wiki entry for PSMC4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PSMC4 gene promoter:
NF-1 Elk-1 GATA-3 p53 STAT5A GATA-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PSMC4 promoter sequence

Search SABiosciences Chromatin IP Primers for PSMC4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSMC4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.11-q13.13 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.11-q13.13

PSMC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMC4 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P040477: view genomic region (about GC identifiers)

Start:	40,477,073 bp from pter	End:	40,487,353 bp from pter
Size:	10,281 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PRS6B_HUMAN, P43686 (See protein sequence)

Recommended Name: 26S protease regulatory subunit 6B

Size: 418 amino acids; 47366 Da

Subunit: Interacts with NR1I3. Interacts with PAAF1. Interacts with TRIM5

Subcellular location: Cytoplasm. Nucleus

1 PDB 3D structure from and Proteopedia for PSMC4:

2DVW (3D)

Secondary accessions: Q96FV5 Q9UBM3 Q9UEX3

Alternative splicing: 2 isoforms: P43686-1 P43686-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PSMC4: NX_P43686

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P43686

PSMC4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_006494.1 NP_694546.1

ENSEMBL proteins:

ENSP00000157812 ENSP00000413869

Reactome Protein details: P43686
Human Recombinant Protein Products for PSMC4:

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	Novus Biologicals PSMC4 Protein Novus Biologicals PSMC4 Lysates
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PSMC4

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000502	proteasome complex	TAS	8603043
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--

PSMC4 for ontologies About GeneDecksing

PSMC4 Antibody Products:

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	Uscn Antibodies for PSMC4
	Search ThermoFisher Antibodies for PSMC4

Assay Products for PSMC4:

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PSMC4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PSMC4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PSMC4 for domains About GeneDecksing

4 InterPro domains/families:

IPR003959 ATPase_AAA_core

IPR003960 ATPase_AAA_CS

IPR005937 26S_Psome_P45

IPR003593 AAA+_ATPase

Graphical View of Domain Structure for InterPro Entry P43686

ProtoNet protein and cluster: P43686

1 Blocks protein family: IPB003960 AAA-protein subdomain

UniProtKB/Swiss-Prot: PRS6B_HUMAN, P43686

Similarity: Belongs to the AAA ATPase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PRS6B_HUMAN, P43686

Function: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or

ATPase) complex confers ATP dependency and substrate specificity to the 26S complex

Genatlas biochemistry entry for PSMC4:

multicatalytic proteinase complex (prosome,macropain,26S) 19/22S regulator of proteasome S6,ATPase subunit 4,51.6kDa

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--
GO:0016887	ATPase activity	TAS	9473509

PSMC4 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for PSMC4:

G0/1 arrest

Increased G1 DNA content

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Psmc4):

embryogenesis

mortality/aging

reproductive system

PSMC4 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Psmc4^tm1Aki for PSMC4

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PSMC4

miRNA Products:		OriGene 3'-UTR Clone (see all 2): PSMC4 Browse MicroRNA Expression Plasmids
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		4 QIAGEN miScript miRNA Assays for microRNAs that regulate PSMC4:
		hsa-miR-4298 hsa-miR-3122 hsa-miR-1302 hsa-miR-3913-5p
		SwitchGear 3'UTR luciferase reporter plasmid: PSMC4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against PSMC4

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PSMC4
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSMC4 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSMC4 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMC4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/78 pathways (see all 78)
Ubiquitinated Orc1 is degraded by the proteasome	1.00	Degradation of ubiquitinated p27/p21 by the 26S proteasome	0.75
Proteasomal cleavage of substrate	0.98	SCF(Skp2)-mediated degradation of p27/p21	0.75
Proteasome mediated degradation of PAK-2p34	0.98	APC/C:Cdh1-mediated degradation of Skp2	0.74
Proteasomal cleavage of substrate	0.98	APC/C:Cdc20 mediated degradation of Securin	0.74

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Chks in Checkpoint Regulation

Chks in Checkpoint Regulation	1.00	p53 Signaling	0.32
G2-M Phase Transition	0.59	DNA Repair Mechanisms	0.32
Estrogen-mediated S-Phase Entry	0.55

HIV Infection

	HIV Infection	1.00			Transcription_Ligand-Dependent Transcription of Retinoid-Target genes	0.28
	Host Interactions of HIV factors	0.64			Transcription Ligand-Dependent Transcription of Retinoid-Target genes	0.28

Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway	1.00			Parkin-Ubiquitin Proteasomal System pathway	0.93
	Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway	0.93

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for PSMC4

	Immune response Antigen presentation by MHC class I
	Transcription Ligand-Dependent Transcription of Retinoid-Target genes
	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

5/19 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PSMC4 (see all 19)

	Remodeling of Adherens Junctions
	CDK5 Pathway
	Estrogen-mediated S-Phase Entry
	G2-M Phase Transition
	DNA Repair Mechanisms

3 GeneGo (Thomson Reuters) Pathways for PSMC4

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Transcription Ligand-Dependent Transcription of Retinoid-Target genes
	Immune response Antigen presentation by MHC class I

2 BioSystems Pathways for PSMC4

	Parkin-Ubiquitin Proteasomal System pathway
	Proteasome Degradation

5/98 Reactome Pathways for PSMC4 (see all 98)

	Ubiquitinated geminin is degraded by the proteasome
	Proteolytic degradation of ubiquitinated-Cdc25A
	Orc1 removal from chromatin
	CDK-mediated phosphorylation and removal of Cdc6
	ER-Phagosome pathway

1 Kegg Pathway (Kegg details for PSMC4):

Proteasome

PSMC4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PSMC4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/996 Interacting proteins for PSMC4 (P43686^{1, 2, 3} ENSP00000157812⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 996)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=2
HIST1H4B	P62805³	I2D: score=2
HIST1H4C	P62805³	I2D: score=2
HIST1H4D	P62805³	I2D: score=2
HIST1H4E	P62805³	I2D: score=2

About this table

Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000084	S phase of mitotic cell cycle	TAS	--
GO:0000209	protein polyubiquitination	TAS	--
GO:0000216	M/G1 transition of mitotic cell cycle	TAS	--

PSMC4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PSMC4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PSMC4
10/38 Novoseek chemical compound relationships for PSMC4 gene (see all 38) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rapamycin	84.6	45	17121914 (2), 20501622 (2), 11160419 (2), 9271419 (2) (see all 34)
potassium	48.2	13	12524283 (2), 9689030 (2), 15883204 (1), 12839862 (1) (see all 10)
ly294002	45.9	3	18958173 (1), 19478560 (1), 15064379 (1)
threonine	45.6	1	14678837 (1)
wortmannin	42.8	2	18958173 (1), 15010863 (1)
oligoribonucleotide	42.4	1	8318536 (1)
phosphatidylinositol	41.2	2	14996711 (1), 15044364 (1)
tetraethylammonium	39.3	8	7696472 (3), 9154902 (1), 2019588 (1), 19332619 (1) (see all 5)
serine	37.2	7	11179022 (1), 1577739 (1), 15877619 (1), 2260978 (1) (see all 7)
sodium	35.8	5	9660885 (1), 10613920 (1), 19464195 (1), 9689030 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about PSMC4 / PRS6B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PSMC4 gene (2 alternative transcripts):

NM_006503.3 NM_153001.2

Unigene Cluster for PSMC4:

Proteasome (prosome, macropain) 26S subunit, ATPase, 4

Hs.211594 [show with all ESTs]

Unigene Representative Sequence: NM_006503

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000157812(uc002omq.3) ENST00000455878(uc002omr.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): PSMC4 Browse OriGene MicroRNA Expression Plasmids
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		hsa-miR-4298 hsa-miR-3122 hsa-miR-1302 hsa-miR-3913-5p
		SwitchGear 3'UTR luciferase reporter plasmid: PSMC4 3' UTR sequence

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		Sirion Biotech Custom design and validation of potent shRNA sequences against PSMC4

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSMC4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSMC4

Additional cDNA sequence:

AF020736.1 AF038965.1 AK290285.1 AK313183.1 BC000343.2 BC010396.1 BC014488.1 BC018811.2

BT007232.1 U27515.1

15 DOTS entries:

DT.449212 DT.100827805 DT.121437047 DT.100827801 DT.100827787 DT.100827791 DT.100827792 DT.91767676

DT.100827778 DT.100827780 DT.121437015 DT.91767660 DT.95080993 DT.95098037 DT.95098088

24/801 AceView cDNA sequences (see all 801):

BU501935 BI754176 CR619473 BQ687513 BE747362 AI538471 BI760699 CR602157

BQ420326 BU157308 AA297661 BU846286 BG389593 BQ690387 BU688959 AI369256

BM806521 BQ688638 BQ690933 BQ231352 BI829232 BQ223190 BM477370 BQ685866

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PSMC4 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11	^	12
SP1:											-												-						-
SP2:																							-						-
SP3:
SP4:
SP5:													-

ECgene alternative splicing isoforms for PSMC4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PSMC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTTTTACAA

About this image

PSMC4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

ES04(HES-4) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PSMC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PSMC4

SOURCE GeneReport for Unigene cluster: Hs.211594

SABiosciences Custom PCR Arrays for PSMC4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSMC4 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSMC4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMC4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMC4 gene from 8/39 species (see all 39) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Psmc4^{1 , 5}	proteasome (prosome, macropain) 26S subunit, ATPase, more^{1, 5}	91.47(n)¹ 99.76(a)¹	7 (16.11 cM)⁵ 23996¹ NM_011874.2¹ NP_036004.2¹ 28041707⁵
African clawed frog (Xenopus laevis)	Amphibia	MGC68784²	proteasome 26S ATPase subunit 4 isoform 1	81.19(n)	BC060362.1
zebrafish (Danio rerio)	Actinopterygii	wufe38b10²	wufe38b10	82.81(n)	326884 BC055215.1
fruit fly (Drosophila melanogaster)	Insecta	Rpt3^{1 , 3}	proteolysis and peptidolysis proteasome endopeptidase³ CG16916-PA¹	87(a) (best of 2)³ 76.78(n)¹ 89.05(a)¹	10A6³ 32047¹ NM_132458.2¹ NP_572686.1¹
worm (Caenorhabditis elegans)	Secernentea	rpt-3¹	Protein RPT-3	68.42(n) 82.89(a)	175925 NM_066028.2 NP_498429.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RPT3(YDR394W)⁴ RPT3¹	One of six ATPases of the 19S regulatory particle of more⁴ Rpt3p¹	59.89(n)¹ 68.9(a)¹	4(1261681-1262967)⁴ 852003^{1, 4} NP_010682.3¹ NP_010682.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	RPT3¹	regulatory particle triple-A ATPase 3	68.16(n) 79.6(a)	835941 NM_125214.5 NP_200637.1
rice (Oryza sativa)	Liliopsida	Os.11446²	Oryza sativa (japonica cultivar-group) OsRPT3 mRNA more	74.97(n)	AK071476.1

ENSEMBL Gene Tree for PSMC4 (if available)
TreeFam Gene Tree for PSMC4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114259450^1,2	F	--	40474913(+)	`TGCGCG/AGGCTA`	2	--	us2k¹		2		WA NA	238
rs139876278^1,2		--	40475070(+)	`CATCTG/TGGGAG`	2	--	us2k¹		0	--	--	--	--
rs187945434^1,2		--	40475079(+)	`AGCTCC/TAAGAA`	2	--	us2k¹		0	--	--	--	--
rs192085335^1,2		--	40475118(+)	`AACACC/TCCTAA`	2	--	us2k¹		0	--	--	--	--
rs114606362^1,2	F	--	40475208(+)	`CTACAC/TACGGT`	2	--	us2k¹		1		WA	118
rs234365^1,2	C,F,A,H	--	40475211(+)	`CACACG/AGTATG`	2	--	us2k¹		16		NS EA NA WA CSA	818
rs234366^1,2	C	--	40475499(+)	`gcacaC/Agcctg`	2	--	us2k¹		4		WA CSA NA	241
rs149835445^1,2		--	40475501(+)	`ACACGC/TCTGTA`	2	--	us2k¹		0	--	--	--	--
rs147472039^1,2		--	40475520(+)	`TGCTTC/GGGAAG`	2	--	us2k¹		0	--	--	--	--
rs200089012^1,2		--	40475522(+)	`TTGGG-/AAAGCT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PSMC4 (40477073 - 40487353 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PSMC4
1 CNV: 4079
1 Indel: 33326

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PSMC4 for disorders           About GeneDecksing

OMIM gene information: 602707    OMIM disorders: --

20/50 diseases for PSMC4 (see all 50):    About MalaCards

parkinson's disease episodic ataxia type 2 focal cortical dysplasia episodic ataxia

timothy syndrome renal clear cell carcinoma herpes simplex nocardiosis

myotonia campylobacteriosis erythromelalgia embryonal rhabdomyosarcoma

hemimegalencephaly autoimmune myocarditis vascular malformations hepatitis b

brugada syndrome tuberous sclerosis rhabdomyosarcoma ganglioglioma

1 disease from the University of Copenhagen DISEASES database for PSMC4:

Nocardiosis

10/17 Novoseek disease relationships for PSMC4 gene (see all 17) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	27.7	13	17041093 (2), 20501622 (2), 8854812 (1), 15175323 (1) (see all 11)
severe mental retardation	20.7	1	14678837 (1)
cancer	13.4	1	8395335 (1)
rhabdomyosarcoma	12	2	15735038 (1), 17585318 (1)
epilepsy	6.19	1	11038262 (1)
glioma	3.16	4	19661320 (2), 18759130 (1), 19671762 (1)
dysplasia	2.28	2	17437409 (1), 15921235 (1)
herpes simplex	0	1	2160050 (1)
virus infection	0	1	2160050 (1)
shock	0	3	1880153 (1), 1730670 (1), 9528776 (1)

Export disorders for PSMC4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PSMC4 gene, integrated from 9 sources (see all 333):
(articles sorted by number of sources associating them with PSMC4)

Utopia: connect your pdf to the dynamic
world of online information

A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily. (PubMed id 8603043)^{1, 2, 3, 9} Choi H.S.... Moore D.D. (1996)
Tat-binding protein 7 is a subunit of the 26S protease. (PubMed id 8060531)^{1, 2, 9} Dubiel W.... Rechsteiner M. (1994)
Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PubMed id 9473509)^{1, 3, 9} Tanahashi N....Tanaka K. (1998)
TRIM5a associates with proteasomal subunits in cells w hile in complex with HIV-1 virions. (PubMed id 22078707)^{1, 2} Lukic Z....Campbell E.M. (2011)
Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. (PubMed id 15831487)^{1, 2} Park Y.... Yoon J.-B. (2005)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{1, 2} Zhang Q.-H.... Chen Z. (2000)
The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes. (PubMed id 8419915)^{1, 2} Ohana B....Rosen C.A. (1993)
E3 ubiquitin ligase RNF2 interacts with the S6' proteasomal ATPase subunit and increases the ATP hydrolysis activity of S6'. (PubMed id 15773819)^{1, 9} Lee S.J....Kang S. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5704	HGNC: 9551	AceView: PSMC4	Ensembl:ENSG00000013275	euGenes: HUgn5704
ECgene: PSMC4	Kegg: 5704	H-InvDB: PSMC4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PSMC4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PSMC4 gene
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Patent Information for PSMC4 gene:
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proteasome (prosome, macropain) 26S subunit, ATPase, 4

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proteasome (prosome, macropain) 26S subunit, ATPase, 4

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