Aliases for PSMC4 Gene
External Ids for PSMC4 Gene
Previous HGNC Symbols for PSMC4 Gene
Previous GeneCards Identifiers for PSMC4 Gene
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for PSMC4 Gene
PSMC4 (Proteasome 26S Subunit, ATPase 4) is a Protein Coding gene. Diseases associated with PSMC4 include Myotonia and Brugada Syndrome. Among its related pathways are Cell Cycle Checkpoints and Mitotic Metaphase and Anaphase. GO annotations related to this gene include hydrolase activity and four-way junction helicase activity.
UniProtKB/Swiss-Prot for PSMC4 Gene
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.