Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PSMC3 Gene

Aliases for PSMC3 Gene

  • Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 3 2 3
  • Tbp1 3 4 6
  • 26S Proteasome AAA-ATPase Subunit RPT5 3 4
  • Proteasome 26S Subunit ATPase 3 3 4
  • Proteasome Subunit P50 3 4
  • Tat-Binding Protein 1 3 4
  • TBP-1 3 4
  • Human Immunodeficiency Virus Tat Transactivator Binding Protein-1 3
  • 26S Protease Regulatory Subunit 6A 3

External Ids for PSMC3 Gene

Previous GeneCards Identifiers for PSMC3 Gene

  • GC11M049377
  • GC11M048318
  • GC11M047471
  • GC11M047404
  • GC11M047396
  • GC11M047440
  • GC11M047139

Summaries for PSMC3 Gene

Entrez Gene Summary for PSMC3 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMC3 Gene

PSMC3 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Downstream Signaling Events Of B Cell Receptor (BCR). GO annotations related to this gene include transcription coactivator activity and ATPase activity.

UniProtKB/Swiss-Prot for PSMC3 Gene

  • The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation.

Gene Wiki entry for PSMC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMC3 Gene

Genomics for PSMC3 Gene

Regulatory Elements for PSMC3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PSMC3 Gene

47,418,769 bp from pter
47,426,473 bp from pter
7,705 bases
Minus strand

Genomic View for PSMC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSMC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMC3 Gene

Proteins for PSMC3 Gene

  • Protein details for PSMC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    26S protease regulatory subunit 6A
    Protein Accession:
    Secondary Accessions:
    • B2R8V1
    • Q3B757
    • Q3B865
    • Q53HU5
    • Q6GPG8
    • Q6IBS1
    • Q96HD3

    Protein attributes for PSMC3 Gene

    439 amino acids
    Molecular mass:
    49204 Da
    Quaternary structure:
    • May form a heterodimer with a related family member. Interacts with PAAF1. Interacts with HIV-1 Tat.
    • Sequence=AAI07805.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for PSMC3 Gene

Proteomics data for PSMC3 Gene at MOPED

Post-translational modifications for PSMC3 Gene

  • Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
  • Ubiquitination at Lys16, Lys35, Lys53, Lys56, Lys70, Lys125, Lys146, Lys155, Lys173, Lys211, Lys233, Lys245, Lys250, Lys266, Lys276, Lys278, Lys294, Lys300, Lys372, and Lys397
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMC3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSMC3 (RPT5)

No data available for DME Specific Peptides for PSMC3 Gene

Domains for PSMC3 Gene

Gene Families for PSMC3 Gene

  • AATP :ATPases / AAA-type
  • PSM :Proteasome (prosome, macropain) subunits

Protein Domains for PSMC3 Gene

Suggested Antigen Peptide Sequences for PSMC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P17980
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with PSMC3: view

Function for PSMC3 Gene

Molecular function for PSMC3 Gene

GENATLAS Biochemistry: multicatalytic proteinase complex (prosome,macropain,26S) 19/22S regulator of proteasome ,ATPase subunit,45kDa
UniProtKB/Swiss-Prot Function: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation.

Gene Ontology (GO) - Molecular Function for PSMC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 8419915
GO:0003714 transcription corepressor activity TAS 2194290
GO:0005515 protein binding IPI 16763564
GO:0005524 ATP binding IEA --
GO:0009378 four-way junction helicase activity --
genes like me logo Genes that share ontologies with PSMC3: view
genes like me logo Genes that share phenotypes with PSMC3: view

Animal Models for PSMC3 Gene

MGI Knock Outs for PSMC3:

Animal Model Products

CRISPR Products

miRNA for PSMC3 Gene

miRTarBase miRNAs that target PSMC3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMC3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PSMC3 Gene

Localization for PSMC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMC3 Gene

Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for PSMC3 Gene COMPARTMENTS Subcellular localization image for PSMC3 gene
Compartment Confidence
cytosol 4
nucleus 4
peroxisome 2

Gene Ontology (GO) - Cellular Components for PSMC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 17323924
GO:0000932 cytoplasmic mRNA processing body ISS --
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with PSMC3: view

Pathways for PSMC3 Gene

SuperPathways for PSMC3 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 Chks in Checkpoint Regulation
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
5 Mitotic Metaphase and Anaphase
genes like me logo Genes that share pathways with PSMC3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PSMC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0001824 blastocyst development IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with PSMC3: view

Compounds for PSMC3 Gene

(2) Novoseek inferred chemical compound relationships for PSMC3 Gene

Compound -log(P) Hits PubMed IDs
leucine 29.4 3
atp 16.1 2
genes like me logo Genes that share compounds with PSMC3: view

Transcripts for PSMC3 Gene

Unigene Clusters for PSMC3 Gene

Proteasome (prosome, macropain) 26S subunit, ATPase, 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMC3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PSMC3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMC3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: -
SP3: -

Relevant External Links for PSMC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSMC3 Gene

mRNA expression in normal human tissues for PSMC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMC3 Gene

SOURCE GeneReport for Unigene cluster for PSMC3 Gene Hs.250758

genes like me logo Genes that share expressions with PSMC3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMC3 Gene

Orthologs for PSMC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PSMC3 35
  • 99.62 (n)
  • 99.77 (a)
PSMC3 36
  • 100 (a)
(Bos Taurus)
Mammalia PSMC3 35
  • 91.27 (n)
  • 99.32 (a)
PSMC3 36
  • 96 (a)
(Canis familiaris)
Mammalia PSMC3 35
  • 92.2 (n)
  • 100 (a)
PSMC3 36
  • 99 (a)
(Mus musculus)
Mammalia Psmc3 35
  • 90.21 (n)
  • 99.32 (a)
Psmc3 16
Psmc3 36
  • 99 (a)
(Monodelphis domestica)
Mammalia PSMC3 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia PSMC3 36
  • 64 (a)
(Rattus norvegicus)
Mammalia Psmc3 35
  • 90.81 (n)
  • 98.86 (a)
(Gallus gallus)
Aves PSMC3 35
  • 82.62 (n)
  • 99.05 (a)
PSMC3 36
  • 99 (a)
(Anolis carolinensis)
Reptilia PSMC3 36
  • 98 (a)
African clawed frog
(Xenopus laevis)
Amphibia psmc3-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia psmc3 35
  • 81.48 (n)
  • 98.58 (a)
Str.2886 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8620 35
(Danio rerio)
Actinopterygii psmc3 35
  • 82.67 (n)
  • 98.27 (a)
psmc3 36
  • 99 (a)
wufb39a02 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000616 35
  • 76.56 (n)
  • 84.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tbp-1 35
  • 75.24 (n)
  • 85 (a)
Tbp-1 36
  • 83 (a)
Tbp-1 37
  • 84 (a)
(Caenorhabditis elegans)
Secernentea rpt-5 35
  • 70.15 (n)
  • 82.52 (a)
rpt-5 36
  • 80 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER254W 35
  • 65.45 (n)
  • 70.8 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPT5 35
  • 62.55 (n)
  • 70.46 (a)
RPT5 36
  • 68 (a)
RPT5 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21209g 35
  • 61.12 (n)
  • 70.6 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1712 35
(Glycine max)
eudicotyledons Gma.2136 35
thale cress
(Arabidopsis thaliana)
eudicotyledons RPT5B 35
  • 68.62 (n)
  • 77.56 (a)
(Hordeum vulgare)
Liliopsida Hv.3715 35
(Zea mays)
Liliopsida Zm.6155 35
(Oryza sativa)
Liliopsida Os.15233 35
Os06g0173100 35
  • 70.81 (n)
  • 78.23 (a)
(Triticum aestivum)
Liliopsida Ta.22845 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04414 35
  • 67.88 (n)
  • 74.58 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpt5 35
  • 62.15 (n)
  • 71.91 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4352 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 86 (a)
Species with no ortholog for PSMC3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMC3 Gene

Gene Tree for PSMC3 (if available)
Gene Tree for PSMC3 (if available)

Paralogs for PSMC3 Gene Pseudogenes for PSMC3 Gene

genes like me logo Genes that share paralogs with PSMC3: view

No data available for Paralogs for PSMC3 Gene

Variants for PSMC3 Gene

Sequence variations from dbSNP and Humsavar for PSMC3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2242511 -- 47,420,113(-) CCTCC(A/G)TTTCT intron-variant
rs2293579 -- 47,419,207(-) CTGTC(C/T)TGTCC intron-variant
rs2293580 -- 47,418,732(-) GGAGG(A/T)GTGGG downstream-variant-500B
rs3781624 -- 47,421,700(-) gctcc(A/G)gcctg intron-variant
rs3781625 -- 47,421,529(-) TCTGG(A/G)CTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMC3 Gene

Variant ID Type Subtype PubMed ID
nsv897323 CNV Loss 21882294
nsv832141 CNV Loss 17160897
nsv825871 CNV Gain 20364138
nsv897325 CNV Loss 21882294

Relevant External Links for PSMC3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMC3 Gene

Disorders for PSMC3 Gene

(2) Novoseek inferred disease relationships for PSMC3 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 48.3 7
tumors 0 4
genes like me logo Genes that share disorders with PSMC3: view

No data available for UniProtKB/Swiss-Prot for PSMC3 Gene

Publications for PSMC3 Gene

  1. A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator. (PMID: 2194290) Nelbock P. … Rosen C.A. (Science 1990) 3 4 23
  2. The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes. (PMID: 8419915) Ohana B. … Rosen C.A. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 4 23
  3. Localization of genes encoding two human one-domain members of the AAA family: PSMC5 (the thyroid hormone receptor-interacting protein, TRIP1) and PSMC3 (the Tat-binding protein, TBP1). (PMID: 9048938) Hoyle J. … Fisher E.M. (Hum. Genet. 1997) 2 3 23
  4. Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N. … Tanaka K. (Biochem. Biophys. Res. Commun. 1998) 2 3 23
  5. Molecular cloning and characterization of a novel TBP-1 interacting protein (TBPIP):enhancement of TBP-1 action on Tat by TBPIP. (PMID: 9345291) Tanaka T. … Sato M. (Biochem. Biophys. Res. Commun. 1997) 3 23

Products for PSMC3 Gene

Sources for PSMC3 Gene

Back to Top