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PSMC3 Gene

protein-coding   GIFtS: 67
GCID: GC11M047440

Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 31 2     TBP-12 3
TBP12 3 5     Tat-Binding Protein 12 3
Proteasome 26S Subunit ATPase 32 3     26S Protease Regulatory Subunit 6A2
Proteasome Subunit P502 3     Human Immunodeficiency Virus Tat Transactivator Binding Protein-12
26S Proteasome AAA-ATPase Subunit RPT52 3     

External Ids:    HGNC: 95491   Entrez Gene: 57022   Ensembl: ENSG000001659167   OMIM: 1868525   UniProtKB: P179803   

Export aliases for PSMC3 gene to outside databases

Previous GC identifers: GC11M049377 GC11M048318 GC11M047471 GC11M047404 GC11M047396 GC11M047139


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PSMC3 Gene:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes,
a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are
composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a
base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in
an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome,
the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a
member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2
for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription
complex. A pseudogene has been identified on chromosome 9. (provided by RefSeq, Jul 2008)

GeneCards Summary for PSMC3 Gene:
PSMC3 (proteasome (prosome, macropain) 26S subunit, ATPase, 3) is a protein-coding gene. Diseases associated with PSMC3 include meningitis, and hiv-1. GO annotations related to this gene include transcription coactivator activity and ATPase activity.

UniProtKB/Swiss-Prot: PRS6A_HUMAN, P17980
Function: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory
(or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case
of HIV-1 infection, suppresses Tat-mediated transactivation

Gene Wiki entry for PSMC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the PSMC3 gene promoter:
         RFX1   AML1a   Egr-1   XBP-1   HNF-4alpha2   Nkx2-5   YY1   HNF-4alpha1   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSMC3 promoter sequence
   Search Chromatin IP Primers for PSMC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSMC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

PSMC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMC3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M047440:  view genomic region     (about GC identifiers)

Start:
47,440,320 bp from pter      End:
47,448,024 bp from pter
Size:
7,705 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PRS6A_HUMAN, P17980 (See protein sequence)
Recommended Name: 26S protease regulatory subunit 6A  
Size: 439 amino acids; 49204 Da
Subunit: May form a heterodimer with a related family member. Interacts with PAAF1. Interacts with HIV-1 Tat
Sequence caution: Sequence=AAI07805.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2R8V1 Q3B757 Q3B865 Q53HU5 Q6GPG8 Q6IBS1 Q96HD3

Explore the universe of human proteins at neXtProt for PSMC3: NX_P17980

Explore proteomics data for PSMC3 at MOPED

Post-translational modifications: 

  • Sumoylated by UBE2I in response to MEKK1-mediated stimuli1
  • Ubiquitination2 at Lys16, Lys35, Lys53, Lys56, Lys70, Lys125, Lys146, Lys155, Lys173, Lys211,
                                 Lys233, Lys245, Lys250, Lys266, Lys276, Lys278, Lys294, Lys300, Lys372, Lys397
  • Modification sites at PhosphoSitePlus

  • See PSMC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002795.2  
    ENSEMBL proteins: 
     ENSP00000473652   ENSP00000298852   ENSP00000433097   ENSP00000433596   ENSP00000437291  
     ENSP00000431144   ENSP00000432970   ENSP00000432103   ENSP00000435141  
    Reactome Protein details: P17980

    PSMC3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for PSMC3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AATP: ATPases / AAA-type
    PSM: Proteasome (prosome, macropain) subunits

    5 InterPro protein domains:
     IPR003959 ATPase_AAA_core
     IPR003960 ATPase_AAA_CS
     IPR027417 P-loop_NTPase
     IPR005937 26S_Psome_P45
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry P17980

    ProtoNet protein and cluster: P17980

    1 Blocks protein domain: IPB003960 AAA-protein subdomain

    UniProtKB/Swiss-Prot: PRS6A_HUMAN, P17980
    Similarity: Belongs to the AAA ATPase family


    PSMC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRS6A_HUMAN, P17980
    Function: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory
    (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case
    of HIV-1 infection, suppresses Tat-mediated transactivation

         Genatlas biochemistry entry for PSMC3:
    multicatalytic proteinase complex (prosome,macropain,26S) 19/22S regulator of proteasome ,ATPase subunit,45kDa

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003713transcription coactivator activity TAS8419915
    GO:0003714transcription corepressor activity TAS2194290
    GO:0005515protein binding IPI16763564
    GO:0005524ATP binding IEA--
         
    PSMC3 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for PSMC3:
     Decreased viability  Decreased viability of wild-ty  Decreased viability with pacli  G0/1 arrest 
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Psmc3):
     embryogenesis  mortality/aging  reproductive system 

    PSMC3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Psmc3tm1Aki for PSMC3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PSMC3
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PSMC3

    miRNA
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    miRTarBase miRNAs that target PSMC3:
    hsa-mir-23a-3p (MIRT050417), hsa-mir-92a-3p (MIRT049107), hsa-mir-196a-5p (MIRT048151)

    Block miRNA regulation of human, mouse, rat PSMC3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PSMC3
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    GenScript: all cDNA clones in your preferred vector: PSMC3 (NM_002804)
    Sino Biological Human cDNA Clone for PSMC3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMC3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMC3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRS6A_HUMAN, P17980: Cytoplasm (Potential). Nucleus (Potential). Cytoplasm, P-body (By similarity).
    Note=Colocalizes with TRIM5 in the cytoplasmic bodies (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    peroxisome2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex TAS8811196
    GO:0000932cytoplasmic mRNA processing body ISS--
    GO:0005634nucleus TAS2194290
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----

    PSMC3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PSMC3 About   (see all 30)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    CDK-mediated phosphorylation and removal of Cdc60.94
    Destabilization of mRNA by AUF1 (hnRNP D0)0.88
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    G1/S DNA Damage Checkpoints0.87
    Ubiquitin-dependent degradation of Cyclin D10.94
    CDT1 association with the CDC6-ORC-origin complex0.87
    Ubiquitin-dependent degradation of Cyclin D0.94
    SCF(Skp2)-mediated degradation of p27/p210.86
    2Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Chks in Checkpoint Regulation
    Chks in Checkpoint Regulation0.59
    SREBP Proteolysis0.43
    G2-M Phase Transition0.59
    DNA Repair Mechanisms0.32
    Estrogen-mediated S-Phase Entry0.55
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PSMC3 (see all 19)
        Remodeling of Adherens Junctions
    CDK5 Pathway
    Estrogen-mediated S-Phase Entry
    G2-M Phase Transition
    DNA Repair Mechanisms

    3 GeneGo (Thomson Reuters) Pathways for PSMC3
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Antigen presentation by MHC class I

    3 BioSystems Pathways for PSMC3
        Parkin-Ubiquitin Proteasomal System pathway
    Proteasome Degradation
    TNF-alpha/NF-kB Signaling Pathway


    Selected Reactome Pathways for PSMC3 (see all 24)
        SCF(Skp2)-mediated degradation of p27/p21
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
    SCF-beta-TrCP mediated degradation of Emi1
    Ubiquitin-dependent degradation of Cyclin D1
    Orc1 removal from chromatin


    2 Kegg Pathways  (Kegg details for PSMC3):
        Proteasome
    Epstein-Barr virus infection


    PSMC3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including PSMC3: 
              Nuclear Receptors & Coregulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PSMC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PSMC3 (P179801, 2, 3 ENSP000002988524) via UniProtKB, MINT, STRING, and/or I2D (see all 1172)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0001824blastocyst development IEA--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--

    PSMC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PSMC3 (PRS6A)

    2 Novoseek inferred chemical compound relationships for PSMC3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 29.4 5 19325002 (2), 11463857 (1)
    atp 16.1 2 11463857 (1), 1825027 (1)



    PSMC3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PSMC3 gene: 
    NM_002804.4  

    Unigene Cluster for PSMC3:

    Proteasome (prosome, macropain) 26S subunit, ATPase, 3
    Hs.250758  [show with all ESTs]
    Unigene Representative Sequence: NM_002804
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000602866 ENST00000298852(uc001nfh.2) ENST00000530912 ENST00000524447
    ENST00000530887 ENST00000530651 ENST00000531051 ENST00000527906 ENST00000526993
    ENST00000531653 ENST00000528362 ENST00000529500
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      QuantiFast Probe-based Assays in human, mouse, rat PSMC3

    Additional mRNA sequence: 

    AK222485.1 AK291896.1 AK313518.1 BC008713.2 BC073165.1 BC106920.2 BC107804.1 CR456731.1 
    M34079.1 

    21 DOTS entries:

    DT.97866785  DT.40268256  DT.97848050  DT.100837408  DT.100801874  DT.100837415  DT.120725396  DT.95077613 
    DT.100837417  DT.92460749  DT.100837411  DT.92460761  DT.100753653  DT.100837402  DT.100837406  DT.100837414 
    DT.100837407  DT.120725370  DT.120725381  DT.120725386  DT.121185929 

    Selected AceView cDNA sequences (see all 769):

    BP337852 BQ006781 BM559756 T08934 F36636 AW247630 AW248876 CR605143 
    BP361350 AL527377 BG680931 BM677592 BX279900 AL526945 BQ028960 BE728867 
    BQ941175 BM910710 BQ721001 AA080973 BG697423 BQ001519 AL552674 CR621417 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PSMC3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                    -                                                               
    SP2:                    -                                                               
    SP3:                    -                                                               
    SP4:                                                                                    


    ECgene alternative splicing isoforms for PSMC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PSMC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGGCATCC
    PSMC3 Expression
    About this image


    PSMC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Kidney (Urinary System)
             Metanephros
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    PSMC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PSMC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.250758
        Pathway & Disease-focused RT2 Profiler PCR Array including PSMC3: 
              Nuclear Receptors & Coregulators in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PSMC3 gene from Selected species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Psmc31 , 5 proteasome (prosome, macropain) 26S subunit, ATPase more1, 5 90.21(n)1
    99.32(a)1
      2 (50.44 cM)5
    191821  NM_008948.21  NP_032974.21 
     910540095 
    chicken
    (Gallus gallus)
    Aves PSMC31 proteasome (prosome, macropain) 26S subunit, ATPase, more 82.62(n)
    99.05(a)
      423182  NM_001031190.1  NP_001026361.1 
    lizard
    (Anolis carolinensis)
    Reptilia PSMC36
    proteasome (prosome, macropain) 26S subunit, ATPas...
    98(a)
    1 ↔ 1
    1(44174621-44184122)
    African clawed frog
    (Xenopus laevis)
    Amphibia psmc3-prov2 proteasome (prosome, macropain) 26S subunit, ATPase more 81.66(n)    BC054164.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb39a022 Transcribed sequence with weak similarity to protein more 81.68(n)    CA496015.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tbp-11 , 3 proteolysis and peptidolysis proteasome
    endopeptidase3
    Tat-binding protein-11
    84(a)3
    75.24(n)1
    85(a)1
      95B13
    428051  NM_079740.41  NP_524464.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rpt-51 rpt-5 70.15(n)
    82.52(a)
      172238  NM_059271.3  NP_491672.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPT5(YOR117W)4
    RPT51
    One of six ATPases of the 19S regulatory particle of more4
    RPT51
    62.55(n)1
    70.46(a)1
      15(545029-546333)4
    8542841, 4  NP_014760.31  NP_014760.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RPT5B1 RPT5B 68.62(n)
    77.56(a)
      837431  NM_100781.4  NP_172384.1 
    rice
    (Oryza sativa)
    Liliopsida Os.152332 Oryza sativa (japonica cultivar-group) OsRPT5b mRNA more 74.82(n)    AK065612.1 


    ENSEMBL Gene Tree for PSMC3 (if available)
    TreeFam Gene Tree for PSMC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PSMC3 gene
    Selected SIMAP similar genes for PSMC3 using alignment to 9 protein entries:     PRS6A_HUMAN (see all proteins) (see all similar genes):
    KATNAL2    DKFZp666D103    PSMC1    PEX6    PSMC2    PSMC4
    AFG3L2    DKFZp434K0126    PSMC6    PSMC5    PEX1    SPG7
    ATAD2B    VCP    ATAD2    DKFZp667C165    SPATA5L1    SPATA5

    PSMC3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PSMC3
    PGOHUM00000236398


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for PSMC3 (see all 250)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105406181,2
    C--47368817(+) actct-/GTcatcc 1 -- int10--------
    rs107428031,2
    C,F,A,H--47439938(+) AGGGGG/ACCCAA 1 -- ds500113Minor allele frequency- A:0.37NS NA WA CSA EA 482
    rs765159481,2
    C,F--47440036(+) CCGAAA/GGTGAA 1 -- ds50012Minor allele frequency- G:0.02NA 122
    rs1179843761,2
    F--47440051(+) TGGCTT/CCTATC 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs1459934641,2
    --47440126(+) GGGGAC/GAGAGG 1 -- ds50010--------
    rs1177242861,2
    C,F--47440146(+) GGCCTG/CAAGGC 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs1387953691,2
    --47440244(+) AGGCGG/TCAGCA 1 -- ds50010--------
    rs22935801,2
    C,F,A,H--47440283(-) GGAGGT/AGTGGG 1 -- ds500115Minor allele frequency- A:0.33EA NS NA WA CSA 2281
    rs2018389631,2
    --47440349(+) ATTGCA/GCACTT 1 -- ut310--------
    rs1146886641,2
    C,F--47440362(+) GCCGTG/AAGACT 1 -- ut311Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for PSMC3 (47440320 - 47448024 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PSMC3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897323CNV Loss21882294
    nsv897325CNV Loss21882294
    nsv832141CNV Loss17160897
    nsv825871CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PSMC3
    DNA2.0 Custom Variant and Variant Library Synthesis for PSMC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 186852    OMIM disorders: --

    14 diseases for PSMC3:    
    About MalaCards
    meningitis    hiv-1    labyrinthitis    huntington's disease
    parkinson's disease    ataxia    neuroblastoma    thyroiditis
    prostatitis    prostate cancer    leukemia    cerebritis
    breast cancer    malaria


    PSMC3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for PSMC3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 48.3 9 10806355 (1), 9617816 (1), 11463857 (1), 14665636 (1) (see all 7)
    tumors 0 4 10339605 (2), 14556007 (1), 14665636 (1)


    Export disorders for PSMC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PSMC3 gene, integrated from 10 sources (see all 152):
    (articles sorted by number of sources associating them with PSMC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Localization of genes encoding two human one-domain members of the AAA family: PSMC5 (the thyroid hormone receptor-interacting protein, TRIP1) and PSMC3 (the Tat-binding protein, TBP1). (PubMed id 9048938)1, 3, 9 Hoyle J....Fisher E.M. (Hum. Genet. 1997)
    2. The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes. (PubMed id 8419915)1, 2, 9 Ohana B....Rosen C.A. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    3. A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator. (PubMed id 2194290)1, 2, 9 Nelbock P.... Rosen C.A. (Science 1990)
    4. Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PubMed id 9473509)1, 3, 9 Tanahashi N....Tanaka K. (Biochem. Biophys. Res. Commun. 1998)
    5. Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. (PubMed id 17709345)1, 2 Jakobs A.... Niedenthal R. (Nucleic Acids Res. 2007)
    6. Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. (PubMed id 15831487)1, 2 Park Y.... Yoon J.-B. (Mol. Cell. Biol. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Identification, purification, and characterization of a PA700- dependent activator of the proteasome. (PubMed id 8621709)1, 2 Demartino G.N.... Slaughter C.A. (J. Biol. Chem. 1996)
    9. Cloning and heterogeneous in vivo expression of Tat binding protein-1 (TBP-1) in the mouse. (PubMed id 9714759)1, 9 Nakamura T....Sato M. (Biochim. Biophys. Acta 1998)
    10. Tat-binding protein-1 (TBP-1), an ATPase of 19S regulatory particles of the 26S proteasome, enhances androgen receptor function in cooperation with TBP-1-interacting protein/Hop2. (PubMed id 19325002)1, 9 Satoh T....Mori M. (Endocrinology 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5702 HGNC: 9549 AceView: PSMC3 Ensembl:ENSG00000165916 euGenes: HUgn5702
    ECgene: PSMC3 Kegg: 5702 H-InvDB: PSMC3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PSMC3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PSMC3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PSMC3 gene:
    Search GeneIP for patents involving PSMC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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