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Aliases for PSMC3 Gene

Aliases for PSMC3 Gene

  • Proteasome 26S Subunit, ATPase 3 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 3 2 3
  • 26S Proteasome AAA-ATPase Subunit RPT5 3 4
  • Proteasome Subunit P50 3 4
  • Tat-Binding Protein 1 3 4
  • TBP-1 3 4
  • Tbp1 3 4
  • Human Immunodeficiency Virus Tat Transactivator Binding Protein-1 3
  • 26S Protease Regulatory Subunit 6A 3
  • Testicular Secretory Protein Li 42 3
  • Proteasome 26S Subunit ATPase 3 4

External Ids for PSMC3 Gene

Previous GeneCards Identifiers for PSMC3 Gene

  • GC11M049377
  • GC11M048318
  • GC11M047471
  • GC11M047404
  • GC11M047396
  • GC11M047440
  • GC11M047139
  • GC11M047556
  • GC11M047949
  • GC11M050800
  • GC11M051595
  • GC11M052257

Summaries for PSMC3 Gene

Entrez Gene Summary for PSMC3 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMC3 Gene

PSMC3 (Proteasome 26S Subunit, ATPase 3) is a Protein Coding gene. Diseases associated with PSMC3 include Hiv-1. Among its related pathways are RET signaling and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include hydrolase activity and ATPase activity.

UniProtKB/Swiss-Prot for PSMC3 Gene

  • Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

Gene Wiki entry for PSMC3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMC3 Gene

Genomics for PSMC3 Gene

Regulatory Elements for PSMC3 Gene

Enhancers for PSMC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G047373 1.8 FANTOM5 ENCODE dbSUPER 18.4 +49.8 49831 6.2 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A YBX1 ZNF2 ZNF766 CBX5 FNBP4 NUP160 ENSG00000200090 C1QTNF4 SLC39A13 ENSG00000270060 PSMC3 ZNF408 SPI1 ENSG00000255197
GH11G047399 1.6 FANTOM5 ENCODE dbSUPER 13 +25.7 25713 2.5 HDGF PKNOX1 WRNIP1 ZNF2 TCF12 GLIS2 ELK1 REST TBX21 SMARCA4 SPI1 PSMC3 FNBP4 ENSG00000255197 MADD C11orf49 CELF1 MIR4487
GH11G047371 1 dbSUPER 18.4 +54.1 54146 1.7 CREB3L1 ZNF766 ELK1 ZNF207 FOS KDM4B ZNF592 CREB3 MBD2 SMARCA4 C1QTNF4 ENSG00000255197 PSMC3 NUP160 FNBP4 ZNF408 SLC39A13 ENSG00000270060 ENSG00000200090 DDB2
GH11G047506 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6.6 -87.1 -87109 14.4 HDGF PKNOX1 WRNIP1 ZFP64 SIN3A FEZF1 ZNF2 FOS JUNB REST FNBP4 NUP160 ENSG00000200090 C1QTNF4 SLC39A13 CELF1 ENSG00000270060 DDB2 NDUFS3 PTPMT1
GH11G047387 2 FANTOM5 Ensembl ENCODE dbSUPER 6.2 +34.3 34264 8.8 HDGF CREB3L1 AGO1 SIN3A FEZF1 ZNF766 ZNF143 ZNF207 FOS DEK SPI1 C1QTNF4 MYBPC3 FNBP4 CELF1 ENSG00000255197 PSMC3 LRP4 MADD GC11M053136
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSMC3 on UCSC Golden Path with GeneCards custom track

Promoters for PSMC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000039682 -127 2000 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for PSMC3 Gene

Chromosome:
11
Start:
47,418,769 bp from pter
End:
47,426,473 bp from pter
Size:
7,705 bases
Orientation:
Minus strand

Genomic View for PSMC3 Gene

Genes around PSMC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMC3 Gene

Proteins for PSMC3 Gene

  • Protein details for PSMC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17980-PRS6A_HUMAN
    Recommended name:
    26S protease regulatory subunit 6A
    Protein Accession:
    P17980
    Secondary Accessions:
    • B2R8V1
    • Q3B757
    • Q3B865
    • Q53HU5
    • Q6GPG8
    • Q6IBS1
    • Q96HD3

    Protein attributes for PSMC3 Gene

    Size:
    439 amino acids
    Molecular mass:
    49204 Da
    Quaternary structure:
    • Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC3 and few additional components (PubMed:27428775, PubMed:27342858). Interacts with PAAF1 (PubMed:15831487). Interacts with HIV-1 Tat (PubMed:2194290).
    SequenceCaution:
    • Sequence=AAI07805.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PSMC3 Gene

neXtProt entry for PSMC3 Gene

Post-translational modifications for PSMC3 Gene

  • Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
  • Ubiquitination at isoforms=16, Lys35, Lys56, Lys70, Lys125, isoforms=146, isoforms=173, Lys211, Lys233, isoforms=245, isoforms=250, Lys266, isoforms=276, Lys278, isoforms=294, Lys300, Lys372, and Lys397
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSMC3 (RPT5)
  • Cloud-Clone Corp. Antibodies for PSMC3
  • Santa Cruz Biotechnology (SCBT) Antibodies for PSMC3

No data available for DME Specific Peptides for PSMC3 Gene

Domains & Families for PSMC3 Gene

Gene Families for PSMC3 Gene

Suggested Antigen Peptide Sequences for PSMC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17980

UniProtKB/Swiss-Prot:

PRS6A_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with PSMC3: view

Function for PSMC3 Gene

Molecular function for PSMC3 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (prosome,macropain,26S) 19/22S regulator of proteasome ,ATPase subunit,45kDa
UniProtKB/Swiss-Prot Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

Gene Ontology (GO) - Molecular Function for PSMC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003713 transcription coactivator activity TAS --
GO:0003714 transcription corepressor activity TAS --
GO:0005515 protein binding IPI 16763564
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PSMC3: view
genes like me logo Genes that share phenotypes with PSMC3: view

Animal Models for PSMC3 Gene

MGI Knock Outs for PSMC3:

Animal Model Products

CRISPR Products

miRNA for PSMC3 Gene

miRTarBase miRNAs that target PSMC3

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMC3 Gene

Localization for PSMC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMC3 Gene

Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMC3 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
peroxisome 2

Gene Ontology (GO) - Cellular Components for PSMC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS,IDA 17323924
GO:0000932 P-body ISS --
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA,TAS 2194290
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with PSMC3: view

Pathways & Interactions for PSMC3 Gene

SuperPathways for PSMC3 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMC3: view

Gene Ontology (GO) - Biological Process for PSMC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0001824 blastocyst development IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
genes like me logo Genes that share ontologies with PSMC3: view

No data available for SIGNOR curated interactions for PSMC3 Gene

Drugs & Compounds for PSMC3 Gene

(4) Drugs for PSMC3 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 807
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMC3: view

Transcripts for PSMC3 Gene

Unigene Clusters for PSMC3 Gene

Proteasome (prosome, macropain) 26S subunit, ATPase, 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMC3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: -
SP3: -
SP4:

Relevant External Links for PSMC3 Gene

GeneLoc Exon Structure for
PSMC3
ECgene alternative splicing isoforms for
PSMC3

Expression for PSMC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMC3 Gene

Protein differential expression in normal tissues from HIPED for PSMC3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMC3 Gene



Protein tissue co-expression partners for PSMC3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSMC3 Gene:

PSMC3

SOURCE GeneReport for Unigene cluster for PSMC3 Gene:

Hs.250758

Evidence on tissue expression from TISSUES for PSMC3 Gene

  • Lung(4.8)
  • Nervous system(4.8)
  • Liver(4.6)
  • Kidney(4.5)
  • Skin(3.2)
  • Intestine(2.6)
  • Eye(2.4)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with PSMC3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMC3 Gene

Orthologs for PSMC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMC3 34 35
  • 99.62 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMC3 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMC3 34 35
  • 92.2 (n)
cow
(Bos Taurus)
Mammalia PSMC3 34 35
  • 91.27 (n)
rat
(Rattus norvegicus)
Mammalia Psmc3 34
  • 90.81 (n)
mouse
(Mus musculus)
Mammalia Psmc3 34 16 35
  • 90.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PSMC3 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMC3 34 35
  • 82.62 (n)
lizard
(Anolis carolinensis)
Reptilia PSMC3 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmc3 34
  • 81.48 (n)
Str.2886 34
African clawed frog
(Xenopus laevis)
Amphibia psmc3-prov 34
zebrafish
(Danio rerio)
Actinopterygii psmc3 34 35
  • 82.67 (n)
wufb39a02 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8620 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000616 34
  • 76.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tbp-1 34 36 35
  • 75.24 (n)
worm
(Caenorhabditis elegans)
Secernentea rpt-5 34 35
  • 70.15 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER254W 34
  • 65.45 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPT5 34 35 37
  • 62.55 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21209g 34
  • 61.12 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RPT5B 34
  • 68.62 (n)
soybean
(Glycine max)
eudicotyledons Gma.2136 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1712 34
rice
(Oryza sativa)
Liliopsida Os06g0173100 34
  • 70.81 (n)
Os.15233 34
barley
(Hordeum vulgare)
Liliopsida Hv.3715 34
wheat
(Triticum aestivum)
Liliopsida Ta.22845 34
corn
(Zea mays)
Liliopsida Zm.6155 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 86 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU04414 34
  • 67.88 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpt5 34
  • 62.15 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4352 34
Species where no ortholog for PSMC3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMC3 Gene

ENSEMBL:
Gene Tree for PSMC3 (if available)
TreeFam:
Gene Tree for PSMC3 (if available)

Paralogs for PSMC3 Gene

Pseudogenes.org Pseudogenes for PSMC3 Gene

genes like me logo Genes that share paralogs with PSMC3: view

No data available for Paralogs for PSMC3 Gene

Variants for PSMC3 Gene

Sequence variations from dbSNP and Humsavar for PSMC3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000107979 -- 47,426,312(+) ACCAG(A/G)CGGGA utr-variant-5-prime
rs1000567223 -- 47,421,798(+) CAGGC(A/G)CACAC intron-variant
rs1000907217 -- 47,426,471(+) CTGGC(C/T)ACAGG utr-variant-5-prime
rs1000932226 -- 47,419,608(+) TAATC(C/T)CAGCA intron-variant
rs1000959229 -- 47,426,626(+) CGAGG(C/G/T)CCTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PSMC3 Gene

Variant ID Type Subtype PubMed ID
nsv554210 CNV loss 21841781
nsv825871 CNV gain 20364138
nsv832141 CNV loss 17160897

Variation tolerance for PSMC3 Gene

Residual Variation Intolerance Score: 23.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMC3 Gene

Disorders for PSMC3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSMC3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search PSMC3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSMC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMC3
genes like me logo Genes that share disorders with PSMC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMC3 Gene

Publications for PSMC3 Gene

  1. Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N. … Tanaka K. (Biochem. Biophys. Res. Commun. 1998) 2 3 22 64
  2. Localization of genes encoding two human one-domain members of the AAA family: PSMC5 (the thyroid hormone receptor-interacting protein, TRIP1) and PSMC3 (the Tat-binding protein, TBP1). (PMID: 9048938) Hoyle J. … Fisher E.M. (Hum. Genet. 1997) 2 3 22 64
  3. The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes. (PMID: 8419915) Ohana B. … Rosen C.A. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 4 22 64
  4. A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator. (PMID: 2194290) Nelbock P. … Rosen C.A. (Science 1990) 3 4 22 64
  5. Tat-binding protein-1 (TBP-1), an ATPase of 19S regulatory particles of the 26S proteasome, enhances androgen receptor function in cooperation with TBP-1-interacting protein/Hop2. (PMID: 19325002) Satoh T. … Mori M. (Endocrinology 2009) 3 22 64

Products for PSMC3 Gene