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Aliases for PSMC3 Gene

Aliases for PSMC3 Gene

  • Proteasome 26S Subunit, ATPase 3 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 3 2 3
  • 26S Proteasome AAA-ATPase Subunit RPT5 3 4
  • Proteasome 26S Subunit ATPase 3 3 4
  • Proteasome Subunit P50 3 4
  • Tat-Binding Protein 1 3 4
  • TBP-1 3 4
  • Tbp1 3 4
  • Human Immunodeficiency Virus Tat Transactivator Binding Protein-1 3
  • Testicular Secretory Protein Li 42 3

External Ids for PSMC3 Gene

Previous GeneCards Identifiers for PSMC3 Gene

  • GC11M049377
  • GC11M048318
  • GC11M047471
  • GC11M047404
  • GC11M047396
  • GC11M047440
  • GC11M047139
  • GC11M047556
  • GC11M047949

Summaries for PSMC3 Gene

Entrez Gene Summary for PSMC3 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMC3 Gene

PSMC3 (Proteasome 26S Subunit, ATPase 3) is a Protein Coding gene. Diseases associated with PSMC3 include Hiv-1. Among its related pathways are Cell Cycle Checkpoints and Mitotic Metaphase and Anaphase. GO annotations related to this gene include hydrolase activity and ATPase activity.

UniProtKB/Swiss-Prot for PSMC3 Gene

  • The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation.

Gene Wiki entry for PSMC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMC3 Gene

Genomics for PSMC3 Gene

Regulatory Elements for PSMC3 Gene

Enhancers for PSMC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSMC3 on UCSC Golden Path with GeneCards custom track

Promoters for PSMC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSMC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSMC3 Gene

47,418,769 bp from pter
47,426,473 bp from pter
7,705 bases
Minus strand

Genomic View for PSMC3 Gene

Genes around PSMC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMC3 Gene

Proteins for PSMC3 Gene

  • Protein details for PSMC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    26S protease regulatory subunit 6A
    Protein Accession:
    Secondary Accessions:
    • B2R8V1
    • Q3B757
    • Q3B865
    • Q53HU5
    • Q6GPG8
    • Q6IBS1
    • Q96HD3

    Protein attributes for PSMC3 Gene

    439 amino acids
    Molecular mass:
    49204 Da
    Quaternary structure:
    • May form a heterodimer with a related family member. Interacts with PAAF1. Interacts with HIV-1 Tat.
    • Sequence=AAI07805.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for PSMC3 Gene

Proteomics data for PSMC3 Gene at MOPED

Post-translational modifications for PSMC3 Gene

  • Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
  • Ubiquitination at Lys 16, Lys 35, Lys 56, Lys 70, Lys 125, Lys 146, Lys 173, Lys 211, Lys 233, Lys 245, Lys 250, Lys 266, Lys 276, Lys 278, Lys 294, Lys 300, Lys 372, and Lys 397
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSMC3 Gene

Domains & Families for PSMC3 Gene

Gene Families for PSMC3 Gene

Protein Domains for PSMC3 Gene

Suggested Antigen Peptide Sequences for PSMC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AAA ATPase family.
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with PSMC3: view

Function for PSMC3 Gene

Molecular function for PSMC3 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (prosome,macropain,26S) 19/22S regulator of proteasome ,ATPase subunit,45kDa
UniProtKB/Swiss-Prot Function:
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation.

Gene Ontology (GO) - Molecular Function for PSMC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMC3: view
genes like me logo Genes that share phenotypes with PSMC3: view

Animal Models for PSMC3 Gene

MGI Knock Outs for PSMC3:

Animal Model Products

miRNA for PSMC3 Gene

miRTarBase miRNAs that target PSMC3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMC3 Gene

Localization for PSMC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMC3 Gene

Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for PSMC3 Gene COMPARTMENTS Subcellular localization image for PSMC3 gene
Compartment Confidence
cytosol 5
nucleus 5
peroxisome 2

Gene Ontology (GO) - Cellular Components for PSMC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0008540 proteasome regulatory particle, base subcomplex IBA --
GO:0031595 nuclear proteasome complex IBA --
genes like me logo Genes that share ontologies with PSMC3: view

Pathways & Interactions for PSMC3 Gene

SuperPathways for PSMC3 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 Interleukin-3, 5 and GM-CSF signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
5 Immune System
genes like me logo Genes that share pathways with PSMC3: view

Gene Ontology (GO) - Biological Process for PSMC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSMC3: view

No data available for SIGNOR curated interactions for PSMC3 Gene

Drugs & Compounds for PSMC3 Gene

(4) Drugs for PSMC3 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 776
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMC3: view

Transcripts for PSMC3 Gene

Unigene Clusters for PSMC3 Gene

Proteasome (prosome, macropain) 26S subunit, ATPase, 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMC3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: -
SP3: -

Relevant External Links for PSMC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSMC3 Gene

mRNA expression in normal human tissues for PSMC3 Gene

Protein differential expression in normal tissues from HIPED for PSMC3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMC3 Gene

SOURCE GeneReport for Unigene cluster for PSMC3 Gene Hs.250758

genes like me logo Genes that share expression patterns with PSMC3: view

Protein tissue co-expression partners for PSMC3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMC3 Gene

Orthologs for PSMC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PSMC3 35
  • 91.27 (n)
  • 99.32 (a)
PSMC3 36
  • 96 (a)
(Canis familiaris)
Mammalia PSMC3 35
  • 92.2 (n)
  • 100 (a)
PSMC3 36
  • 99 (a)
(Mus musculus)
Mammalia Psmc3 35
  • 90.21 (n)
  • 99.32 (a)
Psmc3 16
Psmc3 36
  • 99 (a)
(Pan troglodytes)
Mammalia PSMC3 35
  • 99.62 (n)
  • 99.77 (a)
PSMC3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Psmc3 35
  • 90.81 (n)
  • 98.86 (a)
(Monodelphis domestica)
Mammalia PSMC3 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia PSMC3 36
  • 64 (a)
(Gallus gallus)
Aves PSMC3 35
  • 82.62 (n)
  • 99.05 (a)
PSMC3 36
  • 99 (a)
(Anolis carolinensis)
Reptilia PSMC3 36
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia psmc3 35
  • 81.48 (n)
  • 98.58 (a)
Str.2886 35
African clawed frog
(Xenopus laevis)
Amphibia psmc3-prov 35
(Danio rerio)
Actinopterygii psmc3 35
  • 82.67 (n)
  • 98.27 (a)
wufb39a02 35
psmc3 36
  • 99 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8620 35
fruit fly
(Drosophila melanogaster)
Insecta Tbp-1 37
  • 84 (a)
Tbp-1 35
  • 75.24 (n)
  • 85 (a)
Tbp-1 36
  • 83 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000616 35
  • 76.56 (n)
  • 84.69 (a)
(Caenorhabditis elegans)
Secernentea rpt-5 35
  • 70.15 (n)
  • 82.52 (a)
rpt-5 36
  • 80 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER254W 35
  • 65.45 (n)
  • 70.8 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21209g 35
  • 61.12 (n)
  • 70.6 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPT5 35
  • 62.55 (n)
  • 70.46 (a)
RPT5 36
  • 68 (a)
RPT5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons RPT5B 35
  • 68.62 (n)
  • 77.56 (a)
(Glycine max)
eudicotyledons Gma.2136 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1712 35
(Hordeum vulgare)
Liliopsida Hv.3715 35
(Oryza sativa)
Liliopsida Os.15233 35
Os06g0173100 35
  • 70.81 (n)
  • 78.23 (a)
(Triticum aestivum)
Liliopsida Ta.22845 35
(Zea mays)
Liliopsida Zm.6155 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4352 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04414 35
  • 67.88 (n)
  • 74.58 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpt5 35
  • 62.15 (n)
  • 71.91 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 86 (a)
Species with no ortholog for PSMC3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMC3 Gene

Gene Tree for PSMC3 (if available)
Gene Tree for PSMC3 (if available)

Paralogs for PSMC3 Gene Pseudogenes for PSMC3 Gene

genes like me logo Genes that share paralogs with PSMC3: view

No data available for Paralogs for PSMC3 Gene

Variants for PSMC3 Gene

Sequence variations from dbSNP and Humsavar for PSMC3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2242511 -- 47,420,113(-) CCTCC(A/G)TTTCT intron-variant
rs2293579 -- 47,419,207(-) CTGTC(C/T)TGTCC intron-variant
rs2293580 -- 47,418,732(-) GGAGG(A/T)GTGGG downstream-variant-500B
rs7120244 -- 47,419,598(+) CTCAT(A/G)CCTAT intron-variant
rs7120262 -- 47,419,656(+) AAATC(A/G)AGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMC3 Gene

Variant ID Type Subtype PubMed ID
nsv897323 CNV Loss 21882294
nsv832141 CNV Loss 17160897
nsv825871 CNV Gain 20364138
nsv897325 CNV Loss 21882294

Variation tolerance for PSMC3 Gene

Residual Variation Intolerance Score: 23.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.55% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PSMC3 Gene

Disorders for PSMC3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSMC3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search PSMC3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSMC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PSMC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMC3 Gene

Publications for PSMC3 Gene

  1. Localization of genes encoding two human one-domain members of the AAA family: PSMC5 (the thyroid hormone receptor-interacting protein, TRIP1) and PSMC3 (the Tat-binding protein, TBP1). (PMID: 9048938) Hoyle J. … Fisher E.M. (Hum. Genet. 1997) 2 3 23 67
  2. Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N. … Tanaka K. (Biochem. Biophys. Res. Commun. 1998) 2 3 23
  3. Tat-binding protein-1 (TBP-1), an ATPase of 19S regulatory particles of the 26S proteasome, enhances androgen receptor function in cooperation with TBP-1-interacting protein/Hop2. (PMID: 19325002) Satoh T. … Mori M. (Endocrinology 2009) 3 23
  4. TBP-1 protects the human oncosuppressor p14ARF from proteasomal degradation. (PMID: 17334400) Pollice A. … La Mantia G. (Oncogene 2007) 3 23
  5. Functional and physical interaction of the human ARF tumor suppressor with Tat-binding protein-1. (PMID: 14665636) Pollice A. … La Mantia G. (J. Biol. Chem. 2004) 3 23

Products for PSMC3 Gene

Sources for PSMC3 Gene