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Aliases for PSMC3 Gene

Aliases for PSMC3 Gene

  • Proteasome 26S Subunit, ATPase 3 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 3 2 3
  • 26S Proteasome AAA-ATPase Subunit RPT5 3 4
  • Proteasome Subunit P50 3 4
  • Tat-Binding Protein 1 3 4
  • TBP-1 3 4
  • Tbp1 3 4
  • Human Immunodeficiency Virus Tat Transactivator Binding Protein-1 3
  • 26S Protease Regulatory Subunit 6A 3
  • Testicular Secretory Protein Li 42 3
  • Proteasome 26S Subunit ATPase 3 4

External Ids for PSMC3 Gene

Previous GeneCards Identifiers for PSMC3 Gene

  • GC11M049377
  • GC11M048318
  • GC11M047471
  • GC11M047404
  • GC11M047396
  • GC11M047440
  • GC11M047139
  • GC11M047556
  • GC11M047949
  • GC11M050800
  • GC11M051595

Summaries for PSMC3 Gene

Entrez Gene Summary for PSMC3 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMC3 Gene

PSMC3 (Proteasome 26S Subunit, ATPase 3) is a Protein Coding gene. Diseases associated with PSMC3 include Hiv-1. Among its related pathways are RET signaling and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include hydrolase activity and ATPase activity.

UniProtKB/Swiss-Prot for PSMC3 Gene

  • The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation.

Gene Wiki entry for PSMC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMC3 Gene

Genomics for PSMC3 Gene

Regulatory Elements for PSMC3 Gene

Enhancers for PSMC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F047373 1.6 FANTOM5 ENCODE 18.4 +49.8 49831 6.2 HDGF PKNOX1 CREB3L1 WRNIP1 SIN3A ARID4B YBX1 ZNF2 ZNF766 ZNF207 FNBP4 NUP160 ENSG00000200090 C1QTNF4 SLC39A13 PSMC3 SPI1 ENSG00000255197 ENSG00000270060 MYBPC3
GH11F047399 1.3 FANTOM5 ENCODE 13 +25.7 25713 2.5 HDGF HDAC1 PKNOX1 WRNIP1 ZBTB40 ZNF2 ZEB1 GLIS2 ELK1 EGR1 SPI1 PSMC3 FNBP4 ENSG00000255197 MADD C11orf49 CELF1 MIR4487
GH11F047506 1.7 FANTOM5 Ensembl ENCODE 6.6 -87.0 -87028 14.6 HDGF PKNOX1 WRNIP1 ZFP64 ZNF493 SIN3A FEZF1 ZNF2 ZNF121 GATA2 NUP160 FNBP4 ENSG00000200090 ENSG00000270060 C1QTNF4 DDB2 ZNF408 CELF1 SLC39A13 NDUFS3
GH11F047912 1.8 FANTOM5 Ensembl ENCODE 6 -492.4 -492360 13.2 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 YY1 CBX5 ZNF143 NUP160 FNBP4 ENSG00000270060 ENSG00000200090 DDB2 PTPRJ C1QTNF4 PTPRJ-AS1 MYBPC3 KBTBD4
GH11F047764 1.5 FANTOM5 ENCODE 6.7 -340.7 -340665 4.8 HDGF PKNOX1 ARNT SIN3A DMAP1 ZNF2 YY1 ZNF207 FOS KLF13 NUP160 FNBP4 ENSG00000200090 ENSG00000270060 DDB2 C1QTNF4 PSMC3 PTPRJ ACP2 CELF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSMC3 on UCSC Golden Path with GeneCards custom track

Promoters for PSMC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PSMC3 Gene

47,418,769 bp from pter
47,426,473 bp from pter
7,705 bases
Minus strand

Genomic View for PSMC3 Gene

Genes around PSMC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMC3 Gene

Proteins for PSMC3 Gene

  • Protein details for PSMC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    26S protease regulatory subunit 6A
    Protein Accession:
    Secondary Accessions:
    • B2R8V1
    • Q3B757
    • Q3B865
    • Q53HU5
    • Q6GPG8
    • Q6IBS1
    • Q96HD3

    Protein attributes for PSMC3 Gene

    439 amino acids
    Molecular mass:
    49204 Da
    Quaternary structure:
    • May form a heterodimer with a related family member. Interacts with PAAF1. Interacts with HIV-1 Tat.
    • Sequence=AAI07805.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PSMC3 Gene

neXtProt entry for PSMC3 Gene

Post-translational modifications for PSMC3 Gene

  • Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
  • Ubiquitination at Lys 16, Lys 35, Lys 56, Lys 70, Lys 125, Lys 146, Lys 173, Lys 211, Lys 233, Lys 245, Lys 250, Lys 266, Lys 276, Lys 278, Lys 294, Lys 300, Lys 372, and Lys 397
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSMC3 Gene

Domains & Families for PSMC3 Gene

Gene Families for PSMC3 Gene

Suggested Antigen Peptide Sequences for PSMC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AAA ATPase family.
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with PSMC3: view

Function for PSMC3 Gene

Molecular function for PSMC3 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (prosome,macropain,26S) 19/22S regulator of proteasome ,ATPase subunit,45kDa
UniProtKB/Swiss-Prot Function:
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation.

Gene Ontology (GO) - Molecular Function for PSMC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003713 transcription coactivator activity TAS 8419915
GO:0003714 transcription corepressor activity TAS 2194290
GO:0005515 protein binding IPI 16763564
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PSMC3: view
genes like me logo Genes that share phenotypes with PSMC3: view

Animal Models for PSMC3 Gene

MGI Knock Outs for PSMC3:

Animal Model Products

miRNA for PSMC3 Gene

miRTarBase miRNAs that target PSMC3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMC3 Gene

Localization for PSMC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMC3 Gene

Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMC3 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
peroxisome 2

Gene Ontology (GO) - Cellular Components for PSMC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA,IDA 17323924
GO:0000932 cytoplasmic mRNA processing body ISS --
GO:0005634 nucleus IEA,IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PSMC3: view

Pathways & Interactions for PSMC3 Gene

SuperPathways for PSMC3 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMC3: view

Gene Ontology (GO) - Biological Process for PSMC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0001824 blastocyst development IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
genes like me logo Genes that share ontologies with PSMC3: view

No data available for SIGNOR curated interactions for PSMC3 Gene

Drugs & Compounds for PSMC3 Gene

(4) Drugs for PSMC3 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 794
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMC3: view

Transcripts for PSMC3 Gene

Unigene Clusters for PSMC3 Gene

Proteasome (prosome, macropain) 26S subunit, ATPase, 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMC3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: -
SP3: -

Relevant External Links for PSMC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSMC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMC3 Gene

Protein differential expression in normal tissues from HIPED for PSMC3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMC3 Gene

Protein tissue co-expression partners for PSMC3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSMC3 Gene:


SOURCE GeneReport for Unigene cluster for PSMC3 Gene:

genes like me logo Genes that share expression patterns with PSMC3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMC3 Gene

Orthologs for PSMC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PSMC3 34 35
  • 99.62 (n)
(Monodelphis domestica)
Mammalia PSMC3 35
  • 93 (a)
(Canis familiaris)
Mammalia PSMC3 34 35
  • 92.2 (n)
(Bos Taurus)
Mammalia PSMC3 34 35
  • 91.27 (n)
(Rattus norvegicus)
Mammalia Psmc3 34
  • 90.81 (n)
(Mus musculus)
Mammalia Psmc3 34 16 35
  • 90.21 (n)
(Ornithorhynchus anatinus)
Mammalia PSMC3 35
  • 64 (a)
(Gallus gallus)
Aves PSMC3 34 35
  • 82.62 (n)
(Anolis carolinensis)
Reptilia PSMC3 35
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia psmc3 34
  • 81.48 (n)
Str.2886 34
African clawed frog
(Xenopus laevis)
Amphibia psmc3-prov 34
(Danio rerio)
Actinopterygii psmc3 34 35
  • 82.67 (n)
wufb39a02 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8620 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000616 34
  • 76.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tbp-1 36 34 35
  • 75.24 (n)
(Caenorhabditis elegans)
Secernentea rpt-5 34 35
  • 70.15 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER254W 34
  • 65.45 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPT5 34 35 37
  • 62.55 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21209g 34
  • 61.12 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RPT5B 34
  • 68.62 (n)
(Glycine max)
eudicotyledons Gma.2136 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1712 34
(Oryza sativa)
Liliopsida Os06g0173100 34
  • 70.81 (n)
Os.15233 34
(Hordeum vulgare)
Liliopsida Hv.3715 34
(Triticum aestivum)
Liliopsida Ta.22845 34
(Zea mays)
Liliopsida Zm.6155 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 86 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04414 34
  • 67.88 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpt5 34
  • 62.15 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4352 34
Species where no ortholog for PSMC3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMC3 Gene

Gene Tree for PSMC3 (if available)
Gene Tree for PSMC3 (if available)

Paralogs for PSMC3 Gene Pseudogenes for PSMC3 Gene

genes like me logo Genes that share paralogs with PSMC3: view

No data available for Paralogs for PSMC3 Gene

Variants for PSMC3 Gene

Sequence variations from dbSNP and Humsavar for PSMC3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10540618 -- 47,421,689(+) ACTCT(-/GT)CATCC intron-variant
rs10710820 -- 47,421,655(+) TTTGA(-/T)TTTTT intron-variant
rs10710821 -- 47,422,031(+) TTGGC(-/T)TTTTT intron-variant
rs10742803 -- 47,418,387(+) AGGGG(A/G)CCCAA downstream-variant-500B
rs10838708 -- 47,419,962(+) TTCCT(A/G)GCGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMC3 Gene

Variant ID Type Subtype PubMed ID
nsv554210 CNV loss 21841781
nsv825871 CNV gain 20364138
nsv832141 CNV loss 17160897

Variation tolerance for PSMC3 Gene

Residual Variation Intolerance Score: 23.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMC3 Gene

Disorders for PSMC3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSMC3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search PSMC3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSMC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PSMC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMC3 Gene

Publications for PSMC3 Gene

  1. Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N. … Tanaka K. (Biochem. Biophys. Res. Commun. 1998) 2 3 22 64
  2. Localization of genes encoding two human one-domain members of the AAA family: PSMC5 (the thyroid hormone receptor-interacting protein, TRIP1) and PSMC3 (the Tat-binding protein, TBP1). (PMID: 9048938) Hoyle J. … Fisher E.M. (Hum. Genet. 1997) 2 3 22 64
  3. The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes. (PMID: 8419915) Ohana B. … Rosen C.A. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 4 22 64
  4. A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator. (PMID: 2194290) Nelbock P. … Rosen C.A. (Science 1990) 3 4 22 64
  5. Tat-binding protein-1 (TBP-1), an ATPase of 19S regulatory particles of the 26S proteasome, enhances androgen receptor function in cooperation with TBP-1-interacting protein/Hop2. (PMID: 19325002) Satoh T. … Mori M. (Endocrinology 2009) 3 22 64

Products for PSMC3 Gene