Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PSMC2 Gene

Aliases for PSMC2 Gene

  • Proteasome 26S Subunit, ATPase 2 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 2 3
  • Mammalian Suppressor Of Sgv-1 Of Yeast 2 3
  • 26S Proteasome AAA-ATPase Subunit RPT1 3 4
  • Putative Protein Product Of Nbla10058 2 3
  • Protease 26S Subunit 7 2 3
  • MSS1 3 4
  • Testis Secretory Sperm-Binding Protein Li 197a 3
  • Proteasome 26S Subunit, ATPase, 2 2
  • 26S Protease Regulatory Subunit 7 3
  • Proteasome 26S Subunit ATPase 2 4
  • Protein MSS1 4
  • Nbla10058 3
  • S7 3

External Ids for PSMC2 Gene

Previous GeneCards Identifiers for PSMC2 Gene

  • GC07P101472
  • GC07P102531
  • GC07P102548
  • GC07P102582
  • GC07P102775
  • GC07P102984
  • GC07P097351

Summaries for PSMC2 Gene

Entrez Gene Summary for PSMC2 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011]

GeneCards Summary for PSMC2 Gene

PSMC2 (Proteasome 26S Subunit, ATPase 2) is a Protein Coding gene. Among its related pathways are RET signaling and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include hydrolase activity and ATPase activity.

UniProtKB/Swiss-Prot for PSMC2 Gene

  • Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

Gene Wiki entry for PSMC2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMC2 Gene

Genomics for PSMC2 Gene

Regulatory Elements for PSMC2 Gene

Enhancers for PSMC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G103343 1.2 ENCODE 0.7 +0.2 175 2.2 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 DNAJC2 ENSG00000239486 PMPCB CRYZP1 DPY19L2P2 PSMC2
GH07G103318 0.4 FANTOM5 0.3 -25.3 -25320 0.1 PAF1 RPL23AP95 PMPCB DNAJC2 GC07M103298 PSMC2
GH07G103319 0.3 FANTOM5 0.3 -25.6 -25619 0.2 GC07M103298 PSMC2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSMC2 on UCSC Golden Path with GeneCards custom track

Promoters for PSMC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000216207 246 1800 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for PSMC2 Gene

Chromosome:
7
Start:
103,344,254 bp from pter
End:
103,369,395 bp from pter
Size:
25,142 bases
Orientation:
Plus strand

Genomic View for PSMC2 Gene

Genes around PSMC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMC2 Gene

Proteins for PSMC2 Gene

  • Protein details for PSMC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35998-PRS7_HUMAN
    Recommended name:
    26S protease regulatory subunit 7
    Protein Accession:
    P35998
    Secondary Accessions:
    • A4D0Q1
    • B7Z5E2
    • Q3LIA5
    • Q9UDI3

    Protein attributes for PSMC2 Gene

    Size:
    433 amino acids
    Molecular mass:
    48634 Da
    Quaternary structure:
    • Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC2 and few additional components (PubMed:27428775, PubMed:27342858). Interacts with NDC80 and SQSTM1 (PubMed:9295362, PubMed:10409732). Interacts with PAAF1 (PubMed:15831487). Interacts with HIV-1 Tat. Interacts with TRIM5 (PubMed:22078707).

    Three dimensional structures from OCA and Proteopedia for PSMC2 Gene

    Alternative splice isoforms for PSMC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMC2 Gene

Post-translational modifications for PSMC2 Gene

  • Ubiquitination at Lys46, Lys57, isoforms=84, Lys100, isoforms=110, Lys116, isoforms=120, Lys146, isoforms=2181, isoforms=2210, Lys222, Lys248, isoforms=2268, Lys340, isoforms=2402, Lys407, Lys415, and isoforms=2422
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMC2 Gene

No data available for DME Specific Peptides for PSMC2 Gene

Domains & Families for PSMC2 Gene

Gene Families for PSMC2 Gene

Suggested Antigen Peptide Sequences for PSMC2 Gene

Graphical View of Domain Structure for InterPro Entry

P35998

UniProtKB/Swiss-Prot:

PRS7_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with PSMC2: view

Function for PSMC2 Gene

Molecular function for PSMC2 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (prosome,macropain,26S) 19/22S regulator of proteasome S7,ATPase subunit 2,48.6kDa
UniProtKB/Swiss-Prot Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

Gene Ontology (GO) - Molecular Function for PSMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0016887 ATPase activity IDA 9295362
genes like me logo Genes that share ontologies with PSMC2: view
genes like me logo Genes that share phenotypes with PSMC2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMC2 Gene

Localization for PSMC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMC2 Gene

Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMC2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
peroxisome 2

Gene Ontology (GO) - Cellular Components for PSMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA,IEA 9295362
GO:0000932 P-body ISS,IDA --
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA,IEA 21630459
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with PSMC2: view

Pathways & Interactions for PSMC2 Gene

SuperPathways for PSMC2 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMC2: view

Gene Ontology (GO) - Biological Process for PSMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0001649 osteoblast differentiation IDA 16210410
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
genes like me logo Genes that share ontologies with PSMC2: view

No data available for SIGNOR curated interactions for PSMC2 Gene

Drugs & Compounds for PSMC2 Gene

(4) Drugs for PSMC2 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 807
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
MLN9708 Pharma Inhibitor Proteasome inhibitor, 20S Proteasome Inhibitor 0
Salinosporamide A Pharma Inhibitor 20S Catalytic Core subunit of the Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMC2: view

Transcripts for PSMC2 Gene

Unigene Clusters for PSMC2 Gene

Proteasome (prosome, macropain) 26S subunit, ATPase, 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMC2 Gene

No ASD Table

Relevant External Links for PSMC2 Gene

GeneLoc Exon Structure for
PSMC2
ECgene alternative splicing isoforms for
PSMC2

Expression for PSMC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMC2 Gene

Protein differential expression in normal tissues from HIPED for PSMC2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMC2 Gene



Protein tissue co-expression partners for PSMC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMC2 Gene:

PSMC2

SOURCE GeneReport for Unigene cluster for PSMC2 Gene:

Hs.437366

Evidence on tissue expression from TISSUES for PSMC2 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Blood(4.4)
  • Skin(3.6)
  • Lung(3.5)
  • Pancreas(3.1)
  • Eye(2.6)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with PSMC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMC2 Gene

Orthologs for PSMC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMC2 34 35
  • 99.62 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMC2 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMC2 34 35
  • 94.15 (n)
cow
(Bos Taurus)
Mammalia PSMC2 34 35
  • 92.76 (n)
rat
(Rattus norvegicus)
Mammalia Psmc2 34
  • 89.38 (n)
mouse
(Mus musculus)
Mammalia Psmc2 34 16 35
  • 88.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PSMC2 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMC2 34 35
  • 85.3 (n)
lizard
(Anolis carolinensis)
Reptilia PSMC2 35
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmc2 34
  • 81.83 (n)
MGC76296 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6003 34
zebrafish
(Danio rerio)
Actinopterygii psmc2 34 35
  • 79.68 (n)
zgc63995 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8644 34
fruit fly
(Drosophila melanogaster)
Insecta Rpt1 36 34 35
  • 73.75 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011174 34
  • 72.75 (n)
worm
(Caenorhabditis elegans)
Secernentea rpt-1 34 35
  • 72.75 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E13773g 34
  • 69.13 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPT1 34 35 37
  • 68.43 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR050C 34
  • 67.53 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RPT1A 34
  • 70 (n)
soybean
(Glycine max)
eudicotyledons Gma.5808 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7468 34
rice
(Oryza sativa)
Liliopsida Os06g0192600 34
  • 71.1 (n)
Os.291 34
barley
(Hordeum vulgare)
Liliopsida Hv.3383 34
wheat
(Triticum aestivum)
Liliopsida Ta.3887 34
corn
(Zea mays)
Liliopsida Zm.5401 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6445 35
  • 91 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpt1 34
  • 66.98 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02840 34
  • 65.51 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8956 34
Species where no ortholog for PSMC2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMC2 Gene

ENSEMBL:
Gene Tree for PSMC2 (if available)
TreeFam:
Gene Tree for PSMC2 (if available)

Paralogs for PSMC2 Gene

Pseudogenes.org Pseudogenes for PSMC2 Gene

genes like me logo Genes that share paralogs with PSMC2: view

No data available for Paralogs for PSMC2 Gene

Variants for PSMC2 Gene

Sequence variations from dbSNP and Humsavar for PSMC2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000003336 -- 103,344,183(+) GCAAA(A/G)CTTTG intron-variant, upstream-variant-2KB
rs1000008716 -- 103,350,284(+) GACCT(A/G)GGTTT intron-variant
rs1000452377 -- 103,357,786(+) GCCTG(G/T)TTTTC intron-variant
rs1000834450 -- 103,361,354(+) AAAAA(A/T)ACAAA intron-variant
rs1000861919 -- 103,349,613(+) CCCAA(C/T)TAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMC2 Gene

Variant ID Type Subtype PubMed ID
nsv5884 CNV insertion 18451855
nsv970926 CNV duplication 23825009

Variation tolerance for PSMC2 Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMC2 Gene

Human Gene Mutation Database (HGMD)
PSMC2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMC2 Gene

Disorders for PSMC2 Gene

Relevant External Links for PSMC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMC2

No disorders were found for PSMC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMC2 Gene

Publications for PSMC2 Gene

  1. New human gene encoding a positive modulator of HIV Tat-mediated transactivation. (PMID: 1377363) Shibuya H. … Matsumoto K. (Nature 1992) 2 3 4 22 64
  2. Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N. … Tanaka K. (Biochem. Biophys. Res. Commun. 1998) 2 3 22 64
  3. TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions. (PMID: 22078707) Lukic Z. … Campbell E.M. (Retrovirology 2011) 3 4 64
  4. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X. … Huang L. (Biochemistry 2007) 3 4 64
  5. Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. (PMID: 15831487) Park Y. … Yoon J.-B. (Mol. Cell. Biol. 2005) 3 4 64

Products for PSMC2 Gene

Sources for PSMC2 Gene

Content
Loading form....