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Aliases for PSMC2 Gene

Aliases for PSMC2 Gene

  • Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 2 3
  • MSS1 3 4 6
  • Mammalian Suppressor Of Sgv-1 Of Yeast 2 3
  • 26S Proteasome AAA-ATPase Subunit RPT1 3 4
  • Putative Protein Product Of Nbla10058 2 3
  • Proteasome 26S Subunit ATPase 2 3 4
  • Protease 26S Subunit 7 2 3
  • S7 3 6
  • 26S Protease Regulatory Subunit 7 3
  • Proteasome 26S Subunit, ATPase, 2 3
  • Proteasome 26S Subunit 2
  • Protein MSS1 4
  • Nbla10058 3
  • ATPase 2
  • 2 2

External Ids for PSMC2 Gene

Summaries for PSMC2 Gene

Entrez Gene Summary for PSMC2 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011]

GeneCards Summary for PSMC2 Gene

PSMC2 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Downstream Signaling Events Of B Cell Receptor (BCR). GO annotations related to this gene include ATPase activity.

UniProtKB/Swiss-Prot for PSMC2 Gene

  • The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, positive modulator of Tat-mediated transactivation.

Gene Wiki entry for PSMC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMC2 Gene

Genomics for PSMC2 Gene

Genomic Location for PSMC2 Gene

Start:
103,344,254 bp from pter
End:
103,369,395 bp from pter
Size:
25,142 bases
Orientation:
Plus strand

Genomic View for PSMC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSMC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMC2 Gene

Regulatory Elements for PSMC2 Gene

Proteins for PSMC2 Gene

  • Protein details for PSMC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35998-PRS7_HUMAN
    Recommended name:
    26S protease regulatory subunit 7
    Protein Accession:
    P35998
    Secondary Accessions:
    • A4D0Q1
    • B7Z5E2
    • Q3LIA5
    • Q9UDI3

    Protein attributes for PSMC2 Gene

    Size:
    433 amino acids
    Molecular mass:
    48634 Da
    Quaternary structure:
    • Interacts with NDC80 and SQSTM1. Interacts with PAAF1. Interacts with HIV-1 Tat. Interacts with TRIM5.

    Alternative splice isoforms for PSMC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMC2 Gene

Proteomics data for PSMC2 Gene at MOPED

Post-translational modifications for PSMC2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys34, Lys46, Lys57, Lys84, Lys100, Lys110, Lys116, Lys120, Lys146, Lys181, Lys210, Lys222, Lys248, Lys267, Lys268, Lys340, Lys402, Lys407, Lys415, and Lys422

Other Protein References for PSMC2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PSMC2 Gene

Domains for PSMC2 Gene

Gene Families for PSMC2 Gene

HGNC:
  • AATP :ATPases / AAA-type
  • PSM :Proteasome (prosome, macropain) subunits

Protein Domains for PSMC2 Gene

Suggested Antigen Peptide Sequences for PSMC2 Gene

Graphical View of Domain Structure for InterPro Entry

P35998

UniProtKB/Swiss-Prot:

PRS7_HUMAN
Family:
  • Belongs to the AAA ATPase family.:
    • P35998
genes like me logo Genes that share domains with PSMC2: view

Function for PSMC2 Gene

Molecular function for PSMC2 Gene

GENATLAS Biochemistry: multicatalytic proteinase complex (prosome,macropain,26S) 19/22S regulator of proteasome S7,ATPase subunit 2,48.6kDa
UniProtKB/Swiss-Prot Function: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, positive modulator of Tat-mediated transactivation.

Gene Ontology (GO) - Molecular Function for PSMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity --
GO:0016887 ATPase activity IDA 9295362
genes like me logo Genes that share ontologies with PSMC2: view
genes like me logo Genes that share phenotypes with PSMC2: view

miRNA for PSMC2 Gene

miRTarBase miRNAs that target PSMC2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PSMC2 Gene

Localization for PSMC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMC2 Gene

Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMC2 Gene COMPARTMENTS Subcellular localization image for PSMC2 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 4
peroxisome 2

Gene Ontology (GO) - Cellular Components for PSMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 17323924
GO:0000932 cytoplasmic mRNA processing body ISS --
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS 16130169
genes like me logo Genes that share ontologies with PSMC2: view

Pathways for PSMC2 Gene

SuperPathways for PSMC2 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.38
2 Chks in Checkpoint Regulation
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.62
5 Mitotic Metaphase and Anaphase
genes like me logo Genes that share pathways with PSMC2: view

Gene Ontology (GO) - Biological Process for PSMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0001649 osteoblast differentiation IDA 16210410
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with PSMC2: view

Transcripts for PSMC2 Gene

Unigene Clusters for PSMC2 Gene

Proteasome (prosome, macropain) 26S subunit, ATPase, 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMC2 Gene

No ASD Table

Relevant External Links for PSMC2 Gene

GeneLoc Exon Structure for
PSMC2
ECgene alternative splicing isoforms for
PSMC2

Expression for PSMC2 Gene

mRNA expression in normal human tissues for PSMC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMC2 Gene

SOURCE GeneReport for Unigene cluster for PSMC2 Gene Hs.437366

genes like me logo Genes that share expressions with PSMC2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMC2 Gene

Orthologs for PSMC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMC2 35
  • 99.62 (n)
  • 100 (a)
PSMC2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSMC2 35
  • 92.76 (n)
  • 100 (a)
PSMC2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMC2 35
  • 94.15 (n)
  • 100 (a)
PSMC2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmc2 35
  • 88.84 (n)
  • 99.77 (a)
Psmc2 16
Psmc2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PSMC2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMC2 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmc2 35
  • 89.38 (n)
  • 99.77 (a)
chicken
(Gallus gallus)
Aves PSMC2 35
  • 85.3 (n)
  • 99.54 (a)
PSMC2 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMC2 36
  • 100 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6003 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76296 35
psmc2 35
  • 81.83 (n)
  • 99.08 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8644 35
zebrafish
(Danio rerio)
Actinopterygii psmc2 35
  • 79.68 (n)
  • 98.85 (a)
psmc2 36
  • 99 (a)
OneToOne
zgc63995 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011174 35
  • 72.75 (n)
  • 91.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rpt1 35
  • 73.75 (n)
  • 91.69 (a)
Rpt1 36
  • 91 (a)
OneToOne
Rpt1 37
  • 91 (a)
worm
(Caenorhabditis elegans)
Secernentea rpt-1 35
  • 72.75 (n)
  • 85.68 (a)
rpt-1 36
  • 85 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR050C 35
  • 67.53 (n)
  • 76.36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPT1 35
  • 68.43 (n)
  • 77.4 (a)
RPT1 36
  • 69 (a)
OneToOne
RPT1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E13773g 35
  • 69.13 (n)
  • 77.62 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7468 35
soybean
(Glycine max)
eudicotyledons Gma.5808 35
thale cress
(Arabidopsis thaliana)
eudicotyledons RPT1A 35
  • 70 (n)
  • 81.67 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3383 35
corn
(Zea mays)
Liliopsida Zm.5401 35
rice
(Oryza sativa)
Liliopsida Os.291 35
Os06g0192600 35
  • 71.1 (n)
  • 80.52 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.3887 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02840 35
  • 65.51 (n)
  • 75.75 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpt1 35
  • 66.98 (n)
  • 74.59 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8956 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6445 36
  • 91 (a)
OneToOne
Species with no ortholog for PSMC2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMC2 Gene

ENSEMBL:
Gene Tree for PSMC2 (if available)
TreeFam:
Gene Tree for PSMC2 (if available)

Paralogs for PSMC2 Gene

Pseudogenes.org Pseudogenes for PSMC2 Gene

genes like me logo Genes that share paralogs with PSMC2: view

No data available for Paralogs for PSMC2 Gene

Variants for PSMC2 Gene

Sequence variations from dbSNP and Humsavar for PSMC2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs10486852 -- 103,351,774(-) ATAGA(A/C)AGTGG intron-variant
rs13223554 -- 103,352,213(+) ACTTA(G/T)TTaaa intron-variant
rs13237775 -- 103,352,119(+) TAATT(C/T)CCTAT intron-variant
rs17136728 -- 103,349,279(+) TCAGA(G/T)ATACT intron-variant
rs17136740 -- 103,349,779(+) CTTTC(A/C/T)GATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMC2 Gene

Variant ID Type Subtype PubMed ID
nsv5884 CNV Insertion 18451855

Relevant External Links for PSMC2 Gene

HapMap Linkage Disequilibrium report
PSMC2
Human Gene Mutation Database (HGMD)
PSMC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMC2 Gene

Disorders for PSMC2 Gene

No disorders were found for PSMC2 Gene.

No data available for UniProtKB/Swiss-Prot for PSMC2 Gene

Publications for PSMC2 Gene

  1. New human gene encoding a positive modulator of HIV Tat-mediated transactivation. (PMID: 1377363) Shibuya H. … Matsumoto K. (Nature 1992) 2 3 4 23
  2. Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N. … Tanaka K. (Biochem. Biophys. Res. Commun. 1998) 2 3 23
  3. Peptide sequencing identifies MSS1, a modulator of HIV Tat-mediated transactivation, as subunit 7 of the 26 S protease. (PMID: 8500623) Dubiel W. … Rechsteiner M. (FEBS Lett. 1993) 3 4
  4. Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins. (PMID: 10409732) Zheng L. … Lee W.-H. (Mol. Cell. Biol. 1999) 3 4
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4

Products for PSMC2 Gene

Sources for PSMC2 Gene

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