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PSMC2 Gene

protein-coding   GIFtS: 65
GCID: GC07P102984

Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 21 2     21
MSS12 3 5     ATPase1
Mammalian Suppressor Of Sgv-1 Of Yeast1 2     Proteasome 26S Subunit1
Protease 26S Subunit 71 2     26S Protease Regulatory Subunit 72
Putative Protein Product Of Nbla100581 2     Nbla100582
Proteasome 26S Subunit ATPase 22 3     Proteasome 26S Subunit, ATPase, 22
26S Proteasome AAA-ATPase Subunit RPT12 3     Protein MSS13
S72 5     

External Ids:    HGNC: 95481   Entrez Gene: 57012   Ensembl: ENSG000001610577   OMIM: 1543655   UniProtKB: P359983   

Export aliases for PSMC2 gene to outside databases

Previous GC identifers: GC07P101472 GC07P102531 GC07P102548 GC07P102582 GC07P102775 GC07P097351


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PSMC2 Gene:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes,
a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are
composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a
base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in
an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome,
the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a
member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to
interact with several of the basal transcription factors so, in addition to participation in proteasome
functions, this subunit may participate in the regulation of transcription. This subunit may also compete with
PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the
transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
(provided by RefSeq, Mar 2011)

GeneCards Summary for PSMC2 Gene:
PSMC2 (proteasome (prosome, macropain) 26S subunit, ATPase, 2) is a protein-coding gene. Diseases associated with PSMC2 include uremic neuropathy, and endocarditis. GO annotations related to this gene include ATPase activity.

UniProtKB/Swiss-Prot: PRS7_HUMAN, P35998
Function: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory
(or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1
infection, positive modulator of Tat-mediated transactivation

Gene Wiki entry for PSMC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PSMC2 gene promoter:
         Bach1   Max1   SRF   Pax-5   SRF (504 AA)   Evi-1   Egr-2   AREB6   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSMC2 promoter sequence
   Search Chromatin IP Primers for PSMC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSMC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1-q22.3   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1-q22.3

PSMC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMC2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P102984:  view genomic region     (about GC identifiers)

Start:
102,984,701 bp from pter      End:
103,009,842 bp from pter
Size:
25,142 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 102,348,337-102,370,208     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PRS7_HUMAN, P35998 (See protein sequence)
Recommended Name: 26S protease regulatory subunit 7  
Size: 433 amino acids; 48634 Da
Subunit: Interacts with NDC80 and SQSTM1. Interacts with PAAF1. Interacts with HIV-1 Tat. Interacts with TRIM5
Secondary accessions: A4D0Q1 Q3LIA5 Q9UDI3

Explore the universe of human proteins at neXtProt for PSMC2: NX_P35998

Explore proteomics data for PSMC2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys34, Lys46, Lys57, Lys84, Lys100, Lys110, Lys116, Lys120, Lys146, Lys181,
                                 Lys210, Lys222, Lys248, Lys267, Lys268, Lys340, Lys402, Lys407, Lys415, Lys422
  • Modification sites at PhosphoSitePlus

  • See PSMC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001191382.1  NP_002794.1  

    ENSEMBL proteins: 
     ENSP00000401724   ENSP00000393027   ENSP00000391211   ENSP00000292644   ENSP00000445546  
    Reactome Protein details: P35998

    PSMC2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AATP: ATPases / AAA-type
    PSM: Proteasome (prosome, macropain) subunits

    5 InterPro protein domains:
     IPR003959 ATPase_AAA_core
     IPR003960 ATPase_AAA_CS
     IPR027417 P-loop_NTPase
     IPR005937 26S_Psome_P45
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry P35998

    ProtoNet protein and cluster: P35998

    1 Blocks protein domain: IPB003960 AAA-protein subdomain

    UniProtKB/Swiss-Prot: PRS7_HUMAN, P35998
    Similarity: Belongs to the AAA ATPase family


    PSMC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRS7_HUMAN, P35998
    Function: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory
    (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1
    infection, positive modulator of Tat-mediated transactivation

         Genatlas biochemistry entry for PSMC2:
    multicatalytic proteinase complex (prosome,macropain,26S) 19/22S regulator of proteasome S7,ATPase subunit
    2,48.6kDa

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005515protein binding IPI16189514
    GO:0005524ATP binding IEA--
    GO:0008233peptidase activity ----
    GO:0016787hydrolase activity ----
         
    PSMC2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PSMC2:
     Decreased viability of wild-ty  G0/1 arrest  Increased G1 DNA content  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PSMC2
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    miRNA
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    miRTarBase miRNAs that target PSMC2:
    hsa-mir-484 (MIRT041958), hsa-mir-16-5p (MIRT031892)

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    3 qRT-PCR Assays for microRNAs that regulate PSMC2:
    hsa-miR-298 hsa-miR-3662 hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidPSMC2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): PSMC2 (NM_001204453)
    Sino Biological Human cDNA Clone for PSMC2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSMC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMC2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRS7_HUMAN, P35998: Cytoplasm. Nucleus. Cytoplasm, P-body (By similarity). Note=Colocalizes with TRIM5 in the
    cytoplasmic bodies (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion4
    peroxisome2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex IDA9295362
    GO:0000932cytoplasmic mRNA processing body ISS--
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm TAS16130169

    PSMC2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PSMC2 About   (see all 30)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    CDK-mediated phosphorylation and removal of Cdc60.94
    Destabilization of mRNA by AUF1 (hnRNP D0)0.88
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    G1/S DNA Damage Checkpoints0.87
    Ubiquitin-dependent degradation of Cyclin D10.94
    CDT1 association with the CDC6-ORC-origin complex0.87
    Ubiquitin-dependent degradation of Cyclin D0.94
    SCF(Skp2)-mediated degradation of p27/p210.86
    2Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Chks in Checkpoint Regulation
    Chks in Checkpoint Regulation0.59
    SREBP Proteolysis0.43
    G2-M Phase Transition0.59
    DNA Repair Mechanisms0.32
    Estrogen-mediated S-Phase Entry0.55
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PSMC2 (see all 19)
        Remodeling of Adherens Junctions
    CDK5 Pathway
    Estrogen-mediated S-Phase Entry
    G2-M Phase Transition
    DNA Repair Mechanisms

    3 GeneGo (Thomson Reuters) Pathways for PSMC2
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Antigen presentation by MHC class I

    3 BioSystems Pathways for PSMC2
        Parkin-Ubiquitin Proteasomal System pathway
    Proteasome Degradation
    TNF-alpha/NF-kB Signaling Pathway


    Selected Reactome Pathways for PSMC2 (see all 24)
        SCF(Skp2)-mediated degradation of p27/p21
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
    SCF-beta-TrCP mediated degradation of Emi1
    Ubiquitin-dependent degradation of Cyclin D1
    Orc1 removal from chromatin


    2 Kegg Pathways  (Kegg details for PSMC2):
        Proteasome
    Epstein-Barr virus infection


    PSMC2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PSMC2
    Interactions:

        GeneGlobe Interaction Network for PSMC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PSMC2 (P359981, 2, 3 ENSP000002926444) via UniProtKB, MINT, STRING, and/or I2D (see all 1156)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMC5P621951, 2, 3, ENSP000003105724EBI-359710,EBI-357745 MINT-4050722 MINT-7945693 MINT-2794171 MINT-7230300 MINT-7947479 I2D: score=8 STRING: ENSP00000310572
    PSMC1P621911, 2, 3, ENSP000002613034EBI-359710,EBI-357598 MINT-4050722 MINT-7945693 MINT-7230300 MINT-7947479 I2D: score=11 STRING: ENSP00000261303
    PSMC4P436862, 3, ENSP000001578124MINT-4050722 MINT-7945693 MINT-7230300 MINT-7947479 I2D: score=9 STRING: ENSP00000157812
    PSMD12O002322, 3, ENSP000003484424MINT-4050722 MINT-7945693 MINT-7230300 MINT-7947479 I2D: score=6 STRING: ENSP00000348442
    PSMD13Q9UNM62, 3, ENSP000003969374MINT-4050722 MINT-7945693 MINT-7947479 I2D: score=8 STRING: ENSP00000396937
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--

    PSMC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PSMC2 (PRS7)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PSMC2 gene (2 alternative transcripts): 
    NM_001204453.1  NM_002803.3  

    Unigene Cluster for PSMC2:

    Proteasome (prosome, macropain) 26S subunit, ATPase, 2
    Hs.437366  [show with all ESTs]
    Unigene Representative Sequence: NM_002803
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000457587 ENST00000425206 ENST00000435765(uc003vbs.3 uc011klo.2)
    ENST00000460021(uc011kln.2) ENST00000292644 ENST00000544811
    miRNA
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    hsa-miR-298 hsa-miR-3662 hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidPSMC2 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat PSMC2
      QuantiFast Probe-based Assays in human, mouse, rat PSMC2

    Additional mRNA sequence: 

    AB075520.1 AK298529.1 AK298821.1 AK312648.1 BC002589.2 D11094.1 

    Selected DOTS entries (see all 28):

    DT.454563  DT.95371272  DT.100886141  DT.101983805  DT.100759381  DT.95371288  DT.86853283  DT.100886139 
    DT.97860622  DT.100676487  DT.91781447  DT.100045643  DT.121065844  DT.100011454  DT.121065784  DT.95177836 
    DT.100886134  DT.100886135  DT.100886137  DT.120861637  DT.121065618  DT.121065747  DT.91781442  DT.95371269 

    Selected AceView cDNA sequences (see all 685):

    BG166796 CF141402 BP371304 BC002589 BP364752 CB143071 BQ270581 AU122277 
    CB147900 BQ053826 BP354196 AI754675 BM510744 AW402162 BM754088 AW250385 
    CB143036 AW247036 CB269771 CB139671 AU102511 BE890989 AA968742 BQ441035 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PSMC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACATACAACT
    PSMC2 Expression
    About this image


    PSMC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Primary Oocyte Primary Follicle
             Oviduct
     
     Kidney (Urinary System)
             Metanephros
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
    PSMC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PSMC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437366
        Custom PCR Arrays for PSMC2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PSMC2 gene from Selected species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Psmc21 , 5 proteasome (prosome, macropain) 26S subunit, ATPase more1, 5 88.84(n)1
    99.77(a)1
      5 (9.97 cM)5
    191811  NM_011188.31  NP_035318.11 
     217852835 
    chicken
    (Gallus gallus)
    Aves PSMC21 proteasome (prosome, macropain) 26S subunit, ATPase, more 85.3(n)
    99.54(a)
      417716  NM_001006225.1  NP_001006225.1 
    lizard
    (Anolis carolinensis)
    Reptilia PSMC26
    proteasome (prosome, macropain) 26S subunit, ATPas...
    100(a)
    1 ↔ 1
    5(95406878-95419776)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.60032 X.laevis xMSS1 mRNA 82.67(n)    X80157.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc639952 similar to proteasome (prosome, macropain) 26S subunit, more 79.8(n)   393941  BC053187.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rpt11 , 3 proteolysis and peptidolysis proteasome
    endopeptidase3
    Regulatory particle triple-A ATPase 11
    91(a)3
    73.75(n)1
    91.69(a)1
      43E73
    357011  NM_058125.51  NP_477473.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rpt-11 rpt-1 72.75(n)
    85.68(a)
      179641  NM_073604.5  NP_506005.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPT1(YKL145W)4
    RPT11
    One of six ATPases of the 19S regulatory particle of more4
    RPT11
    68.43(n)1
    77.4(a)1
      11(174213-175616)4
    8537121, 4  NP_012777.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RPT1A1 RPT1A 70(n)
    81.67(a)
      841812  NM_104252.2  NP_175778.1 
    rice
    (Oryza sativa)
    Liliopsida Os.2912 Oryza sativa (japonica cultivar-group) OsRPT1 mRNA more 74.51(n)    AB033535.1 


    ENSEMBL Gene Tree for PSMC2 (if available)
    TreeFam Gene Tree for PSMC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PSMC2 gene
    Selected SIMAP similar genes for PSMC2 using alignment to 4 protein entries:     PRS7_HUMAN (see all proteins) (see all similar genes):
    DKFZp666D103    PSMC1    PSMC6    PSMC5    PSMC4    PSMC3
    VCP    AFG3L2    DKFZp434K0126    FTSH    SPATA5    SPG7
    YME1L1    ATAD2    PEX1    ATAD2B    KATNAL2    NVL

    PSMC2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PSMC2
    PGOHUM00000238191 PGOHUM00000249730


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PSMC2 (see all 98)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1449697371,2
    --102987340(+) ATTCAC/TATGTA 2 -- us2k10--------
    rs1843274241,2
    --102987358(+) ACTTGC/GGTTGC 2 -- us2k10--------
    rs1164525561,2
    F--102987481(+) AGGTGG/ACATGG 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1872291891,2
    --102987499(+) TTTTAA/GTTTCC 2 -- us2k10--------
    rs1490558591,2
    --102987533(+) CCACAA/GCAGTT 2 -- us2k10--------
    rs624824051,2
    C,F--102987583(+) CAGGAT/GTCCAT 2 -- us2k12Minor allele frequency- G:0.15NA 122
    rs2015458951,2
    C--102987646(+) AACAC-/TTATTTTC 2 -- us2k10--------
    rs749895241,2
    F--102987699(+) TAGGTA/GTGTGG 2 -- us2k11Minor allele frequency- G:0.03NA 120
    rs1925631091,2
    --102987813(+) AAATCA/GGGTTG 2 -- us2k10--------
    rs1173432531,2
    C,F--102987960(+) AGTTTC/TCTTCT 2 -- us2k11Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for PSMC2 (102984701 - 103009842 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PSMC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5884CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PSMC2
    DNA2.0 Custom Variant and Variant Library Synthesis for PSMC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 154365    OMIM disorders: --

    Selected diseases for PSMC2 (see all 22):    
    About MalaCards
    uremic neuropathy    endocarditis    temporal lobe epilepsy    toxoplasmosis
    hiv-1    huntington's disease    neuropathy    hepatitis c virus
    parkinson's disease    hepatitis c    neuroblastoma    tonsillitis
    alzheimer's disease    hepatitis    prostatitis    endotheliitis
    prostate cancer    thyroiditis    cerebritis    malaria


    PSMC2 for disorders           About GeneDecksing


    Export disorders for PSMC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PSMC2 gene, integrated from 10 sources (see all 138):
    (articles sorted by number of sources associating them with PSMC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. New human gene encoding a positive modulator of HIV Tat-mediated transactivation. (PubMed id 1377363)1, 2, 3, 9 Shibuya H....Matsumoto K. (Nature 1992)
    2. Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PubMed id 9473509)1, 3, 9 Tanahashi N....Tanaka K. (Biochem. Biophys. Res. Commun. 1998)
    3. TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions. (PubMed id 22078707)1, 2 Lukic Z.... Campbell E.M. (Retrovirology 2011)
    4. Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. (PubMed id 15831487)1, 2 Park Y.... Yoon J.-B. (Mol. Cell. Biol. 2005)
    5. Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. (PubMed id 15340068)1, 2 Seibenhener M.L....Wooten M.W. (Mol. Cell. Biol. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    8. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    9. Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins. (PubMed id 10409732)1, 2 Zheng L.... Lee W.-H. (Mol. Cell. Biol. 1999)
    10. HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins. (PubMed id 9295362)1, 2 Chen Y.... Lee W.-H. (J. Biol. Chem. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5701 HGNC: 9548 AceView: PSMC2 Ensembl:ENSG00000161057 euGenes: HUgn5701
    ECgene: PSMC2 Kegg: 5701 H-InvDB: PSMC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PSMC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PSMC2 gene:
    Search GeneIP for patents involving PSMC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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