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Aliases for PSMC1 Gene

Aliases for PSMC1 Gene

  • Proteasome 26S Subunit, ATPase 1 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 1 2 3
  • 26S Proteasome AAA-ATPase Subunit RPT2 3 4
  • Proteasome 26S Subunit ATPase 1 3 4
  • P26S4 3 4
  • Proteasome 26S Subunit, ATPase, 1 3
  • Proteasome 26S ATPase Subunit 1 3
  • P56 3
  • S4 3

External Ids for PSMC1 Gene

Previous GeneCards Identifiers for PSMC1 Gene

  • GC14P088228
  • GC14P084538
  • GC14P088712
  • GC14P089792
  • GC14P090722
  • GC14P070897

Summaries for PSMC1 Gene

Entrez Gene Summary for PSMC1 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMC1 Gene

PSMC1 (Proteasome 26S Subunit, ATPase 1) is a Protein Coding gene. Among its related pathways are Cell Cycle Checkpoints and Mitotic Metaphase and Anaphase. GO annotations related to this gene include poly(A) RNA binding and ATPase activity.

UniProtKB/Swiss-Prot for PSMC1 Gene

  • The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

Gene Wiki entry for PSMC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMC1 Gene

Genomics for PSMC1 Gene

Regulatory Elements for PSMC1 Gene

Enhancers for PSMC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSMC1 on UCSC Golden Path with GeneCards custom track

Promoters for PSMC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSMC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSMC1 Gene

Chromosome:
14
Start:
90,256,495 bp from pter
End:
90,275,429 bp from pter
Size:
18,935 bases
Orientation:
Plus strand

Genomic View for PSMC1 Gene

Genes around PSMC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMC1 Gene

Proteins for PSMC1 Gene

  • Protein details for PSMC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62191-PRS4_HUMAN
    Recommended name:
    26S protease regulatory subunit 4
    Protein Accession:
    P62191
    Secondary Accessions:
    • B4DR63
    • P49014
    • Q03527
    • Q6IAW0
    • Q6NW36
    • Q96AZ3

    Protein attributes for PSMC1 Gene

    Size:
    440 amino acids
    Molecular mass:
    49185 Da
    Quaternary structure:
    • Interacts with SCA7. Interacts with NGLY1. Interacts with PAAF1.

    Alternative splice isoforms for PSMC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMC1 Gene

Proteomics data for PSMC1 Gene at MOPED

Post-translational modifications for PSMC1 Gene

  • Ubiquitination at Lys 24, Lys 69, Lys 232, Lys 237, Lys 258, Lys 265, Lys 293, Lys 387, and Lys 423
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for PSMC1

No data available for DME Specific Peptides for PSMC1 Gene

Domains & Families for PSMC1 Gene

Gene Families for PSMC1 Gene

Protein Domains for PSMC1 Gene

Graphical View of Domain Structure for InterPro Entry

P62191

UniProtKB/Swiss-Prot:

PRS4_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with PSMC1: view

Function for PSMC1 Gene

Molecular function for PSMC1 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (prosome,macropain,26S) 19/225 regulator of proteasome,ATPase subunit,51kDa,? same as ATP1A3
UniProtKB/Swiss-Prot Function:
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

Gene Ontology (GO) - Molecular Function for PSMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMC1: view
genes like me logo Genes that share phenotypes with PSMC1: view

Animal Models for PSMC1 Gene

MGI Knock Outs for PSMC1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMC1 Gene

Localization for PSMC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMC1 Gene

Cytoplasm. Nucleus. Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMC1 Gene COMPARTMENTS Subcellular localization image for PSMC1 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PSMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA --
GO:0005829 cytosol TAS --
GO:0008540 proteasome regulatory particle, base subcomplex IBA --
GO:0031595 nuclear proteasome complex IBA --
genes like me logo Genes that share ontologies with PSMC1: view

Pathways & Interactions for PSMC1 Gene

SuperPathways for PSMC1 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin-3, 5 and GM-CSF signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.48
5 Immune System
genes like me logo Genes that share pathways with PSMC1: view

Gene Ontology (GO) - Biological Process for PSMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
genes like me logo Genes that share ontologies with PSMC1: view

No data available for SIGNOR curated interactions for PSMC1 Gene

Drugs & Compounds for PSMC1 Gene

(2) Drugs for PSMC1 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 776
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0

(3) Additional Compounds for PSMC1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PSMC1: view

Transcripts for PSMC1 Gene

Unigene Clusters for PSMC1 Gene

Proteasome (prosome, macropain) 26S subunit, ATPase, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMC1 Gene

No ASD Table

Relevant External Links for PSMC1 Gene

GeneLoc Exon Structure for
PSMC1
ECgene alternative splicing isoforms for
PSMC1

Expression for PSMC1 Gene

mRNA expression in normal human tissues for PSMC1 Gene

mRNA differential expression in normal tissues according to GTEx for PSMC1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.0).

Protein differential expression in normal tissues from HIPED for PSMC1 Gene

This gene is overexpressed in Lymph node (11.3) and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMC1 Gene



SOURCE GeneReport for Unigene cluster for PSMC1 Gene Hs.356654

genes like me logo Genes that share expression patterns with PSMC1: view

Protein tissue co-expression partners for PSMC1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PSMC1 Gene

Orthologs for PSMC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMC1 35
  • 88.41 (n)
  • 99.77 (a)
PSMC1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMC1 35
  • 94.09 (n)
  • 100 (a)
-- 36
  • 91 (a)
OneToMany
PSMC1 36
  • 100 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Psmc1 35
  • 91.82 (n)
  • 100 (a)
Psmc1 16
Psmc1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSMC1 35
  • 99.85 (n)
  • 100 (a)
PSMC1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmc1 35
  • 90.98 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia PSMC1 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMC1 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMC1 35
  • 83.18 (n)
  • 98.64 (a)
PSMC1 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMC1 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmc1 35
  • 82.12 (n)
  • 100 (a)
Str.4828 35
African clawed frog
(Xenopus laevis)
Amphibia pros26.4-prov 35
zebrafish
(Danio rerio)
Actinopterygii psmc1a 35
  • 79.17 (n)
  • 97.73 (a)
wufb05d04 35
psmc1a 36
  • 98 (a)
OneToMany
psmc1b 36
  • 97 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pros26.4 37
  • 90 (a)
Pros26.4 35
  • 74.2 (n)
  • 92.55 (a)
Pros26.4 36
  • 92 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003216 35
  • 73.4 (n)
  • 93.03 (a)
worm
(Caenorhabditis elegans)
Secernentea C10G11.8 37
  • 55 (a)
rpt-2 35
  • 70.99 (n)
  • 85.34 (a)
rpt-2 36
  • 83 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL011W 35
  • 63.93 (n)
  • 73.91 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F14707g 35
  • 66.18 (n)
  • 73.67 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPT2 35
  • 64.98 (n)
  • 73.49 (a)
RPT2 36
  • 72 (a)
OneToOne
RPT2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G20140 35
  • 70.11 (n)
  • 79.33 (a)
soybean
(Glycine max)
eudicotyledons Gma.11305 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6904 35
barley
(Hordeum vulgare)
Liliopsida Hv.12805 35
rice
(Oryza sativa)
Liliopsida Os.144 35
Os07g0691800 35
  • 68.91 (n)
  • 78.61 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.6566 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4829 35
bread mold
(Neurospora crassa)
Ascomycetes NCU11271 35
  • 63.78 (n)
  • 73.32 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpt2 35
  • 66.02 (n)
  • 74.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3260 36
  • 86 (a)
OneToOne
Species with no ortholog for PSMC1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMC1 Gene

ENSEMBL:
Gene Tree for PSMC1 (if available)
TreeFam:
Gene Tree for PSMC1 (if available)

Paralogs for PSMC1 Gene

genes like me logo Genes that share paralogs with PSMC1: view

No data available for Paralogs for PSMC1 Gene

Variants for PSMC1 Gene

Sequence variations from dbSNP and Humsavar for PSMC1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7492435 -- 90,259,760(+) GGGAT(A/T)ACAGG intron-variant
rs7144335 -- 90,265,936(+) AGCCT(A/G)GGAGC intron-variant
rs7145398 -- 90,265,806(+) gtgag(C/T)catga intron-variant
rs8020934 -- 90,256,000(+) GGATT(C/G)TTGCC upstream-variant-2KB
rs8005870 -- 90,256,828(+) CTCAG(A/C)GCAGA intron-variant

Variation tolerance for PSMC1 Gene

Residual Variation Intolerance Score: 43.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for PSMC1 Gene

Disorders for PSMC1 Gene

Relevant External Links for PSMC1

Genetic Association Database (GAD)
PSMC1
Human Genome Epidemiology (HuGE) Navigator
PSMC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMC1

No disorders were found for PSMC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMC1 Gene

Publications for PSMC1 Gene

  1. Association of ataxin-7 with the proteasome subunit S4 of the 19S regulatory complex. (PMID: 11734547) Matilla A. … Fu Y.H. (Hum. Mol. Genet. 2001) 3 4 23 67
  2. Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N. … Tanaka K. (Biochem. Biophys. Res. Commun. 1998) 2 3 23
  3. The E3 ubiquitin ligase parkin is recruited to the 26 S proteasome via the proteasomal ubiquitin receptor Rpn13. (PMID: 25666615) Aguileta M.A. … Husnjak K. (J. Biol. Chem. 2015) 3
  4. DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. (PMID: 25756610) Papp S.J. … Lamia K.A. (Elife 2015) 3
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3

Products for PSMC1 Gene

Sources for PSMC1 Gene

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