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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PSMB9 Gene

protein-coding   GIFtS: 67
GCID: GC06P032821

proteasome (prosome, macropain) subunit, beta type, 9 (large...

(Previous names: proteasome (prosome, macropain) subunit, beta type, 9 (large...)
(Previous symbol: LMP2)
 Explore 64 diseases affiliated with
PSMB9 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PSMB9    

Aliases
for PSMB9 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Proteasome (Prosome, Macropain) Subunit, Beta Type, 9 (Large Multifunctional
Peptidase 2)1 2
     Proteasome Subunit Beta-1i2 3
LMP21 2 3 5     Really Interesting New Gene 12 Protein2 3
RING121 2 3 5     EC 3.4.25.13 8
PSMB6i1 2 3     Proteasome (Prosome, Macropain) Subunit, Beta Type, 9 (Large Multifunctional
Protease 2)1
Beta1i1     Proteasome Catalytic Subunit 1i2
Low Molecular Mass Protein 22 3     Proteasome Subunit Beta 6i2
Macropain Chain 72 3     Proteasome Subunit Beta Type-92
Multicatalytic Endopeptidase Complex Chain 72 3     Proteasome-Related Gene 22
Proteasome Chain 72 3     

External Ids:    HGNC: 95461   Entrez Gene: 56982   Ensembl: ENSG000002400657   OMIM: 1770455   UniProtKB: P280653   

Export aliases for PSMB9 gene to outside databases

Previous GC identifers: GC06P032818 GC06P032582 GC06P032868 GC06P032929 GC06P032812 GC06P032815


Summaries
for PSMB9 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PSMB9:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core
structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings
are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and
cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified
proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the
proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the
class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon
and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic
processing is required to generate a mature subunit. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: PSB9_HUMAN, P28065
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class
I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model
peptides after hydrophobic and basic residues

Gene Wiki entry for PSMB9


Genomic Views
for PSMB9 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  
NT_167248.1  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PSMB9 gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PSMB9 promoter sequence
   Search SABiosciences Chromatin IP Primers for PSMB9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSMB9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

PSMB9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMB9 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P032821:  view genomic region     (about GC identifiers)

Start:
 32,811,913 bp from pter      End:
 32,847,364 bp from pter
Size:
 35,452 bases      Orientation:
 plus strand

6/7 alternative locations (see all 7):
Chr6+,ALT_REF_LOCI_2 32,734,237-32,789,142      Chr6+,ALT_REF_LOCI_5 32,770,238-32,775,925      Chr6+,ALT_REF_LOCI_3 32,789,894-32,825,298     
Chr6+,ALT_REF_LOCI_4 32,898,793-32,904,484      Chr6+,ALT_REF_LOCI_6 32,740,623-32,791,920      Chr6+,ALT_REF_LOCI_1 32,795,520-32,830,948     

Proteins
for PSMB9 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PSB9_HUMAN, P28065 (See protein sequence)
Recommended Name: Proteasome subunit beta type-9 precursor  
Size: 219 amino acids; 23264 Da
Subunit: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core
is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two
end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.
The catalytic chamber with the active sites is on the inside of the barrel. This subunit is part of the
immunoproteasome where it displaces the equivalent houskeeping subunit PSMB6. Interacts with HIV-1 TAT protein
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Developmental stage: Highly expressed in immature dendritic cells (at protein level)
Miscellaneous: Encoded in the MHC class II region
Miscellaneous: A model for self-activation in which residue Thr-21 serves as nucleophile and Lys-53 as proton
donor/acceptor has been proposed. Subunit processing of mammalian beta-subunits proceeds via a novel ordered two-step
mechanism involving autocatalysis
Secondary accessions: B0V0T1 Q16523 Q5JNW4
Alternative splicing: 2 isoforms:  P28065-1   P28065-2   

Explore the universe of human proteins at neXtProt for PSMB9: NX_P28065

Post-translational modifications:

  • Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic
    • activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P28065

    • 4/10 DME Specific Peptides for PSMB9 (P28065) (see all 10)
     YKYREDL  RDGSSGGV  TGTTIMAV  GSDSRVSAG 

    PSMB9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002791.1  
    ENSEMBL proteins: 
     ENSP00000378739   ENSP00000394363   ENSP00000363993   ENSP00000378742   ENSP00000394773  
    Reactome Protein details: P28065
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: PSMB9
    OriGene Protein Over-expression Lysate (see all 3): PSMB9
    OriGene Custom Protein Services for PSMB9 
    GenScript Custom Purified and Recombinant Proteins Services for PSMB9
    Novus Biologicals PSMB9 Proteins
    Novus Biologicals PSMB9 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for PSMB9
    Uscn Proteins for PSMB9

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex TAS8666937
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--


    PSMB9 for ontologies           About GeneDecksing



    PSMB9 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for PSMB9 (LMP2/PSMB9)
    OriGene Antibodies (see all 8): PSMB9
    OriGene Custom Antibody Services for PSMB9 
    GenScript Custom Superior Antibodies Services for PSMB9
    Novus Biologicals PSMB9 Antibodies
    Abcam antibodies for PSMB9 
    Uscn Antibodies for PSMB9
    ThermoFisher Antibody for PSMB9

    Assay Products for PSMB9: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript Custom Assay Services for PSMB9
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PSMB9

    Protein Domains /
    Families
    for PSMB9 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PSMB9 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001353 Proteasome_sua/b
     IPR016050 Proteasome_bsu_CS
     IPR000243 Pept_T1A_subB
     IPR023333 Proteasome_suB-type

    Graphical View of Domain Structure for InterPro Entry P28065

    ProtoNet protein and cluster: P28065

    1 Blocks protein family: IPB000243 Proteasome B-type subunit

    UniProtKB/Swiss-Prot: PSB9_HUMAN, P28065
    Similarity: Belongs to the peptidase T1B family


    Function
    for PSMB9 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PSB9_HUMAN, P28065
    Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
    peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
    proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class
    I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model
    peptides after hydrophobic and basic residues
    Catalytic activity: Cleavage of peptide bonds with very broad specificity
    Induction: Up-regulated by interferon gamma (at protein level). Up-regulated by IRF1. Up-regulated by tumor necrosis
    factor-alpha (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohn's bowel
    disease (CD). Up-regulated by heat shock treatment. Up-regulated by CD40L via the NFKB1 pathway in cancer cells

         Genatlas biochemistry entry for PSMB9:
    multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component 2,beta-type subunit 2,stimulated by
    interferon gamma,involved in the degradation of cytoplasmic antigens for MHC class I antigen presentation pathways

    Enzyme Number (IUBMB): EC 3.4.25.11 2

    miRNA
    Products:            		 OriGene 3'-UTR Clone: PSMB9
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSMB9
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate PSMB9:
    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmid: PSMB9 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSMB9 (see all 7)
    OriGene shRNA RFP: PSMB9
    OriGene siRNA: PSMB9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSMB9

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PSMB9

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSMB9 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSMB9 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PSMB9 (NM_002800)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSMB9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMB9 

    Cell Line
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    Search LifeMap BioReagents cell lines for PSMB9

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMB9

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004298threonine-type endopeptidase activity IEA--
    GO:0005515protein binding IPI--


    PSMB9 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PSMB9:
     Increased HPV18 LCR reporter a  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Psmb9tm1Stl for PSMB9
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Psmb9):
     hematopoietic system  immune system  tumorigenesis 

    PSMB9 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PSMB9 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/24 super-pathways (see all 24) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitinated Orc1 is degraded by the proteasome
    8/77 pathways (see all 77)
    		Ubiquitinated Orc1 is degraded by the proteasome1.00
    		Degradation of ubiquitinated p27/p21 by the 26S proteasome0.75
    		Proteasomal cleavage of substrate0.98
    		SCF(Skp2)-mediated degradation of p27/p210.75
    		Proteasome mediated degradation of PAK-2p340.98
    		APC/C:Cdh1-mediated degradation of Skp20.74
    		Proteasomal cleavage of substrate0.98
    		APC/C:Cdc20 mediated degradation of Securin0.74
    2M Phase
    		M Phase1.00
    		Mitotic Anaphase0.85
    		Mitotic M-M/G1 phases0.88
    		Separation of Sister Chromatids0.80
    		Mitotic Metaphase and Anaphase0.85
    3Chks in Checkpoint Regulation
    		Chks in Checkpoint Regulation1.00
    		Estrogen-mediated S-Phase Entry0.55
    		G2-M Phase Transition0.59
    		DNA Repair Mechanisms0.32
    4Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Class I MHC mediated antigen processing & presentation0.83
    5Immune System
    		Immune System1.00
    		Adaptive Immune System0.59

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for PSMB9
        Immune response Antigen presentation by MHC class I

    5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PSMB9 (see all 12)
        CDK5 Pathway
    SOCS Pathway
    SMAD Signaling Network
    Estrogen-mediated S-Phase Entry
    G2-M Phase Transition

    1 GeneGo (Thomson Reuters) Pathway for PSMB9
        Immune response Antigen presentation by MHC class I

    2 BioSystems Pathways for PSMB9 
        Type II interferon signaling (IFNG)
    Proteasome Degradation

    5/98        Reactome Pathways for PSMB9 (see all 98)
        Ubiquitinated geminin is degraded by the proteasome
    Proteolytic degradation of ubiquitinated-Cdc25A
    Orc1 removal from chromatin
    CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway


    1         Kegg Pathway  (Kegg details for PSMB9):
        Proteasome


    PSMB9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PSMB9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/35 Interacting proteins for PSMB9 (P280651, 2, 3 ENSP000003639934) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRIP1Q9Y3R02, 3MINT-3291791 MINT-3291896 MINT-3291398 I2D: score=1 
    PSMB7Q994361, 3EBI-780725,EBI-603319 I2D: score=2 
    ESR1P033722, 3MINT-3291999 I2D: score=1 
    NCOA1Q157882, 3, ENSP000003209404MINT-3291957 MINT-3291505 MINT-3291694 I2D: score=2 STRING: ENSP00000320940
    NCOA3Q9Y6Q92, 3, ENSP000003610664MINT-3291484 MINT-3291741 MINT-3291927 I2D: score=2 STRING: ENSP00000361066
    About this table

    Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000084S phase of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000216M/G1 transition of mitotic cell cycle TAS--


    PSMB9 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PSMB9 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PSMB9:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PSMB9
    Search CenterWatch for drugs/clinical trials and news about PSMB9 / PSB9 

    Transcripts
    for PSMB9 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PSMB9 gene (2 alternative transcripts): 
    NM_002800.4  NM_148954.2  

    Unigene Cluster for PSMB9:

    Proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
    Hs.654585  [show with all ESTs]
    Unigene Representative Sequence: BM925394
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395330 ENST00000414474 ENST00000464863(uc011dqj.2) ENST00000374859(uc003sga.3)
    ENST00000395333 ENST00000467593 ENST00000453265

    miRNA
    Products:             		 OriGene 3'-UTR Clone: PSMB9
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSMB9
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate PSMB9:
    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmid: PSMB9 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSMB9 (see all 7)
    OriGene shRNA RFP: PSMB9
    OriGene siRNA: PSMB9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSMB9
    Clone
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    GenScript: all cDNA clones in your preferred vector: PSMB9 (NM_002800)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMB9 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PSMB9
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSMB9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSMB9

    Additional cDNA sequence: 

    AK303118.1 BC065513.1 CR541656.1 S75169.1 U01025.1 X62741.1 

    8 DOTS entries:

    DT.100813505  DT.91682912  DT.413654  DT.91730604  DT.121353412  DT.97848033  DT.100691998  DT.121353423 

    24/218 AceView cDNA sequences (see all 218):

    BE842529 BM998687 AA938497 BU944540 AW581206 CR541656 BU728808 AW242683 
    AA316849 BU539272 BQ947748 BI489568 NM_148954 BC065513 BU624503 H27207 
    AJ712408 CR621193 BQ712463 BI832878 CN480870 AI923541 S75169 BM920112 

    GeneLoc Exon Structure


    Expression
    for PSMB9 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PSMB9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCCGGGATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PSMB9 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    OvaryAntral FollicleMature Granulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

    See PSMB9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PSMB9

    SOURCE GeneReport for Unigene cluster: Hs.654585
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    Orthologs
    for PSMB9 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PSMB9 gene from 7/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia PSMB96
    		 --
    		 76(a)
    		 1 ↔ 1
    		 AAWZ02039800(2394-4901)
    African clawed frog
    (Xenopus laevis)    		 Amphibia D87687.12   -- 76.24(n)    D87687.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii AF155579.12   -- 75.68(n)   30665  AF155579.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Prosbeta16
    		 Proteasome beta1 subunit
    		 48(a)
    		 1 → many
    		 2R(11901309-11902285)
    worm
    (Caenorhabditis elegans)    		 Secernentea pbs-16
    		 Proteasome Beta Subunit family member (pbs-1)
    		 36(a)
    		 possible ortholog
    		 IV(1708803-1709752)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons PBA16
    		 proteasome subunit beta type-6
    		 39(a)
    		 1 → many
    		 4(15188748-15191217)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 peptidase, T1 family, putative, expressed
    		 39(a)
    39(a)
    		 many ↔ many
    many ↔ many
    		 6(2090206-2093692)
    2(32458900-32462724)


    ENSEMBL Gene Tree for PSMB9 (if available)
    TreeFam Gene Tree for PSMB9 (if available) 

    Paralogs
    for PSMB9 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PSMB9 gene
    PSMB62  
    4 SIMAP similar genes for PSMB9 using alignment to 8 protein entries:     PSB9_HUMAN (see all proteins):
    PSMB6    PSMB7    PSMB10    PSMB5

    PSMB9 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PSMB9
    PGOHUM00000235434


    Genomic Variants
    for PSMB9 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/172 NCBI SNPs in PSMB9 are shown (see all 172)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1150795131,2
    		C,F,--32562770(+) CAGAGC/AAAAGG 1 -- int11Minor allele frequency- A:0.02NA 120
    rs362295261,2
    		C,F,--32562862(-) AGAAAC/AGGCAC 1 -- int14Minor allele frequency- A:0.06CSA WA NA 242
    rs1135735031,2
    		C,--32562901(+) CGCTAG/-GGAGT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs2414211,2
    		C,H--32562915(-) GGAGCA/GGGAGA 1 -- int13Minor allele frequency- G:0.00EA NA 54
    rs362295281,2
    		C--32563934(-) AAAATA/TGGGCA 1 -- ut510--------
    rs563766591,2
    		C,F,--32564074(+) AGCGCC/AGCGCG 1 -- us2k16Minor allele frequency- A:0.02WA NA 770
    rs1161821201,2
    		C,F,--32564185(+) CCCAGG/ACGGCG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs351006971,2
    		C,F,--32564238(+) AACCGG/AGGACT 1 -- us2k18Minor allele frequency- A:0.02NA CSA 2993
    rs796041651,2
    		C--32564273(-) CATTAC/G/TCCCGG 1 -- us2k11CSA 1
    rs781945761,2
    		C--32564274(-) CCATTA/G/TCCCCG 1 -- us2k11CSA 1

    HapMap Linkage Disequilibrium report for PSMB9 (32811913 - 32847364 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PSMB9: --
    Human Gene Mutation Database (HGMD): PSMB9

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    Disorders / Diseases
    for PSMB9 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PSMB9 for disorders           About GeneDecksing

    OMIM gene information: 177045    OMIM disorders: --

    20/64 diseases for PSMB9 (see all 64):    About MalaCards
    anterior uveitis    infectious mononucleosis    juvenile rheumatoid arthritis    ankylosing spondylitis
    esophageal squamous cell carcinoma    systemic lupus erythematosus    acute promyelocytic leukemia    squamous cell carcinoma
    spondylitis    lupus erythematosus    nasopharynx carcinoma    diabetes mellitus
    graves' disease    atopic dermatitis    ataxia telangiectasia    rheumatoid arthritis
    intestinal tuberculosis    hepatitis c    nasopharyngitis    uveitis

    1 disease from the University of Copenhagen DISEASES database for PSMB9:
    Intestinal tuberculosis

    10/23 Novoseek disease relationships for PSMB9 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nasopharyngeal diseases 76.6 1 17471168 (1)
    diabetes mellitus insulin-dependent 35.4 3 9599304 (1), 7847389 (1), 11601002 (1)
    graves disease 34.4 1 9599304 (1)
    lung carcinoma 34.3 3 9426698 (2), 8803612 (1)
    tumors 32.7 24 15375491 (3), 8803612 (3), 9426698 (3), 8938146 (2) (see all 12)
    nasopharyngeal carcinoma 27.7 1 17471168 (1)
    colorectal tumors 27.5 1 14750179 (1)
    carcinoma renal cell 26 2 11059775 (2)
    hashimotos thyroiditis 25.7 1 9599304 (1)
    colon carcinoma 24.2 1 8803612 (1)

    Genetic Association Database (GAD): PSMB9
    Human Genome Epidemiology (HuGE) Navigator: PSMB9 (31 documents)

    Export disorders for PSMB9 gene to outside databases

    Publications
    for PSMB9 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PSMB9 gene, integrated from 9 sources (see all 215):
    (articles sorted by number of sources associating them with PSMB9)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Second proteasome-related gene in the human MHC class II region. (PubMed id 1922385)1, 2, 3, 9 Kelly A.... Trowsdale J. (1991)
    2. Major histocompatibility-encoded human proteasome LMP2. Genomic organization and a new form of mRNA. (PubMed id 7829535)1, 2, 9 Singal D.P.... Quadri S.A. (1995)
    3. Age dependent impact of LMP polymorphisms on TNFalpha-induced apoptosis in human peripheral blood mononuclear cells. (PubMed id 11772516)1, 4, 9 Mishto M....Franceschi C. (2002)
    4. CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF- kappaB-mediated de novo synthesis of IRF-1. (PubMed id 18694960)1, 2, 9 Moschonas A....Eliopoulos A.G. (2008)
    5. [The frequency of allelic polymorphism of genes encoding immunoproteasome catalytic subunits in acute coronary syndrome patients] (PubMed id 16396320)1, 4, 9 Dosenko V.E....Moibenko A.A. (2005)
    6. Complex association analysis of Graves disease using a set of polymorphic markers. (PubMed id 10924276)1, 2, 9 Chistyakov D.A.... Nosikov V.V. (2000)
    7. A single nucleotide polymorphism of the low molecular mass polypeptide 7 gene influences the interferon response in patients with chronic hepatitis C. (PubMed id 12225333)1, 4, 9 Sugimoto Y....Hayashi N. (2002)
    8. DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing. (PubMed id 1453454)1, 2, 9 Beck S....Trowsdale J. (1992)
    9. Heat shock up-regulates lmp2 and lmp7 and enhances presentation of immunoproteasome-dependent epitopes. (PubMed id 17142736)1, 2 Callahan M.K.... Srivastava P.K. (2006)
    10. The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription. (PubMed id 16957778)1, 2 Zhang H....Shang Y. (2006)

    External Searches for PSMB9 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PSMB9 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5698 HGNC: 9546 AceView: PSMB9 Ensembl:ENSG00000240065 euGenes: HUgn5698
    ECgene: PSMB9 Kegg: 5698 H-InvDB: PSMB9

    Other Databases showing PSMB9 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PSMB9 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PSMB9 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PSMB9 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PSMB9 gene:
    Search GeneIP for patents involving PSMB9

    GeneCards and IP:
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