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Aliases for PSMB9 Gene

Aliases for PSMB9 Gene

  • Proteasome Subunit Beta 9 2 3 5
  • Multicatalytic Endopeptidase Complex Chain 7 3 4
  • Really Interesting New Gene 12 Protein 3 4
  • Large Multifunctional Peptidase 2 2 3
  • Low Molecular Mass Protein 2 3 4
  • Proteasome Subunit Beta-1i 3 4
  • Proteasome Chain 7 3 4
  • Macropain Chain 7 3 4
  • EC 3.4.25.1 4 63
  • PSMB6i 3 4
  • RING12 3 4
  • LMP2 3 4
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 9 (Large Multifunctional Peptidase 2) 3
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 9 (Large Multifunctional Protease 2) 2
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 9 2
  • Proteasome Catalytic Subunit 1i 3
  • Proteasome Subunit Beta 6i 3
  • Proteasome-Related Gene 2 3
  • Beta1i 3

External Ids for PSMB9 Gene

Previous HGNC Symbols for PSMB9 Gene

  • LMP2

Previous GeneCards Identifiers for PSMB9 Gene

  • GC06P032818
  • GC06P032582
  • GC06P032868
  • GC06P032929
  • GC06P032812
  • GC06P032815
  • GC06P032821

Summaries for PSMB9 Gene

Entrez Gene Summary for PSMB9 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. [provided by RefSeq, Mar 2010]

GeneCards Summary for PSMB9 Gene

PSMB9 (Proteasome Subunit Beta 9) is a Protein Coding gene. Diseases associated with PSMB9 include Nasopharyngeal Disease and Eosinophilic Variant Of Chromophobe Renal Cell Carcinoma. Among its related pathways are Cell Cycle Checkpoints and Mitotic Metaphase and Anaphase. GO annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB6.

UniProtKB/Swiss-Prot for PSMB9 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.

Gene Wiki entry for PSMB9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB9 Gene

Genomics for PSMB9 Gene

Regulatory Elements for PSMB9 Gene

Enhancers for PSMB9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSMB9 on UCSC Golden Path with GeneCards custom track

Promoters for PSMB9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSMB9 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PSMB9 gene promoter:

Genomic Location for PSMB9 Gene

Chromosome:
6
Start:
32,844,136 bp from pter
End:
32,859,851 bp from pter
Size:
15,716 bases
Orientation:
Plus strand

Genomic View for PSMB9 Gene

Genes around PSMB9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for PSMB9 Gene

  • Protein details for PSMB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28065-PSB9_HUMAN
    Recommended name:
    Proteasome subunit beta type-9
    Protein Accession:
    P28065
    Secondary Accessions:
    • B0V0T1
    • Q16523
    • Q5JNW4

    Protein attributes for PSMB9 Gene

    Size:
    219 amino acids
    Molecular mass:
    23264 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent houskeeping subunit PSMB6. Component of the spermatoproteasome, a form of the proteasome specifically found in testis. Interacts with HIV-1 TAT protein.
    Miscellaneous:
    • A model for self-activation in which residue Thr-21 serves as nucleophile and Lys-53 as proton donor/acceptor has been proposed. Subunit processing of mammalian beta-subunits proceeds via a novel ordered two-step mechanism involving autocatalysis.
    • Encoded in the MHC class II region.

    Alternative splice isoforms for PSMB9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMB9 Gene

Proteomics data for PSMB9 Gene at MOPED

Post-translational modifications for PSMB9 Gene

  • Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.
  • Ubiquitination at Lys 53 and Lys 215
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PSMB9 Gene

Gene Families for PSMB9 Gene

Graphical View of Domain Structure for InterPro Entry

P28065

UniProtKB/Swiss-Prot:

PSB9_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB9: view

Function for PSMB9 Gene

Molecular function for PSMB9 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component 2,beta-type subunit 2,stimulated by interferon gamma,involved in the degradation of cytoplasmic antigens for MHC class I antigen presentation pathways
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.
UniProtKB/Swiss-Prot Induction:
Up-regulated by interferon gamma (at protein level). Up-regulated by IRF1. Up-regulated by tumor necrosis factor-alpha (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohns bowel disease (CD). Up-regulated by heat shock treatment. Up-regulated by CD40L via the NFKB1 pathway in cancer cells.

Enzyme Numbers (IUBMB) for PSMB9 Gene

genes like me logo Genes that share phenotypes with PSMB9: view

Animal Models for PSMB9 Gene

MGI Knock Outs for PSMB9:

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMB9 Gene

Localization for PSMB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB9 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMB9 Gene COMPARTMENTS Subcellular localization image for PSMB9 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PSMB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with PSMB9: view

Pathways & Interactions for PSMB9 Gene

SuperPathways for PSMB9 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin-3, 5 and GM-CSF signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.48
5 Immune System
genes like me logo Genes that share pathways with PSMB9: view

Gene Ontology (GO) - Biological Process for PSMB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0001889 liver development IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with PSMB9: view

No data available for SIGNOR curated interactions for PSMB9 Gene

Drugs & Compounds for PSMB9 Gene

(7) Drugs for PSMB9 Gene - From: DrugBank, ApexBio, DGIdb, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
carfilzomib Approved Pharma other, Inhibitor, Target Other, 20S Proteasome Inhibitor 0
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 776
Kyprolis Approved July 2012 Pharma 0
Celastrol Pharma Antioxidant, anti-inflammatory and immunosuppressive agent 0
Dihydroeponemycin Pharma Proteasome inhibitor,antitumor reagent,eponemycin ddrivative 0

(4) ApexBio Compounds for PSMB9 Gene

Compound Action Cas Number
Celastrol Antioxidant, anti-inflammatory and immunosuppressive agent 34157-83-0
Dihydroeponemycin Proteasome inhibitor,antitumor reagent,eponemycin ddrivative 126463-64-7
MLN2238 β5 site of the 20S proteasome inhibitor 1072833-77-2
ONX-0914 (PR-957) Immunoproteasome inhibitor,potent and selective 960374-59-8
genes like me logo Genes that share compounds with PSMB9: view

Transcripts for PSMB9 Gene

Unigene Clusters for PSMB9 Gene

Proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB9 Gene

No ASD Table

Relevant External Links for PSMB9 Gene

GeneLoc Exon Structure for
PSMB9
ECgene alternative splicing isoforms for
PSMB9

Expression for PSMB9 Gene

mRNA expression in normal human tissues for PSMB9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSMB9 Gene

This gene is overexpressed in Whole Blood (x10.6) and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for PSMB9 Gene

This gene is overexpressed in Tlymphocyte (19.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMB9 Gene



SOURCE GeneReport for Unigene cluster for PSMB9 Gene Hs.654585

genes like me logo Genes that share expression patterns with PSMB9: view

Protein tissue co-expression partners for PSMB9 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PSMB9 Gene

Orthologs for PSMB9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PSMB9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMB9 35
  • 87.21 (n)
  • 91.78 (a)
PSMB9 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMB9 35
  • 87.6 (n)
  • 91.3 (a)
PSMB9 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmb9 35
  • 84.47 (n)
  • 88.13 (a)
Psmb9 16
Psmb9 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSMB9 35
  • 99.08 (n)
  • 100 (a)
PSMB9 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmb9 35
  • 84.78 (n)
  • 89.95 (a)
oppossum
(Monodelphis domestica)
Mammalia PSMB9 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMB9 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb9 35
  • 67 (n)
  • 71.92 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
psmb9a 35
  • 66.99 (n)
  • 67.65 (a)
psmb9a 36
  • 64 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11923 35
fruit fly
(Drosophila melanogaster)
Insecta Prosbeta1 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pbs-1 36
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE3 36
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5051 36
  • 56 (a)
OneToMany
Species with no ortholog for PSMB9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMB9 Gene

ENSEMBL:
Gene Tree for PSMB9 (if available)
TreeFam:
Gene Tree for PSMB9 (if available)

Paralogs for PSMB9 Gene

Paralogs for PSMB9 Gene

(4) SIMAP similar genes for PSMB9 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PSMB9 Gene

genes like me logo Genes that share paralogs with PSMB9: view

Variants for PSMB9 Gene

Sequence variations from dbSNP and Humsavar for PSMB9 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs17587 - 32,857,313(+) CGAGC(A/G/T)CATCT reference, missense
VAR_051551 -
rs241419 - 32,856,171(-) CACAA(C/G/T)GCCCC reference, missense
rs17213861 - 32,858,490(+) GCAGG(C/T)GCTTC reference, missense
VAR_075258 -

Structural Variations from Database of Genomic Variants (DGV) for PSMB9 Gene

Variant ID Type Subtype PubMed ID
nsv830633 CNV Loss 17160897

Variation tolerance for PSMB9 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.62; 82.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMB9 Gene

Human Gene Mutation Database (HGMD)
PSMB9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMB9 Gene

Disorders for PSMB9 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PSMB9 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
nasopharyngeal disease
  • nasopharyngeal diseases
eosinophilic variant of chromophobe renal cell carcinoma
nasopharyngeal carcinoma
  • malignant neoplasm of nasopharynx
epstein-barr virus-associated gastric carcinoma
  • ebv-associated gastric carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search PSMB9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSMB9

Genetic Association Database (GAD)
PSMB9
Human Genome Epidemiology (HuGE) Navigator
PSMB9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMB9
genes like me logo Genes that share disorders with PSMB9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMB9 Gene

Publications for PSMB9 Gene

  1. Second proteasome-related gene in the human MHC class II region. (PMID: 1922385) Kelly A. … Trowsdale J. (Nature 1991) 2 3 4 23 67
  2. PSMB8 (LMP7) but not PSMB9 (LMP2) gene polymorphisms are associated to pigeon breeder's hypersensitivity pneumonitis. (PMID: 20153157) Camarena A. … Selman M. (Respir Med 2010) 3 23
  3. Impaired antigen processing and presentation machinery is associated with immunotolerant state in chronic hepatitis B virus infection. (PMID: 20300807) Sukriti S. … Sarin S.K. (J. Clin. Immunol. 2010) 3 23
  4. Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma. (PMID: 19202550) Mehta A.M. … Jan Fleuren G. (Genes Chromosomes Cancer 2009) 3 23
  5. [Allele polymorphism of genes coding proteasome subunits is associated with an enhanced risk for arterial hypertension in adolescents]. (PMID: 19526842) Goncharov S.V. … MoA-benko A.A. (Fiziol Zh 2009) 3 23

Products for PSMB9 Gene

Sources for PSMB9 Gene

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