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Aliases for PSMB9 Gene

Aliases for PSMB9 Gene

  • Proteasome Subunit Beta 9 2 3 5
  • Multicatalytic Endopeptidase Complex Chain 7 3 4
  • Really Interesting New Gene 12 Protein 3 4
  • Large Multifunctional Peptidase 2 2 3
  • Low Molecular Mass Protein 2 3 4
  • Proteasome Subunit Beta-1i 3 4
  • Proteasome Chain 7 3 4
  • Macropain Chain 7 3 4
  • EC 3.4.25.1 4 61
  • PSMB6i 3 4
  • RING12 3 4
  • LMP2 3 4
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 9 (Large Multifunctional Peptidase 2) 3
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 9 (Large Multifunctional Protease 2) 2
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 9 2
  • Proteasome Catalytic Subunit 1i 3
  • Proteasome Subunit Beta Type-9 3
  • Proteasome Subunit Beta 6i 3
  • Proteasome-Related Gene 2 3
  • Beta1i 3

External Ids for PSMB9 Gene

Previous HGNC Symbols for PSMB9 Gene

  • LMP2

Previous GeneCards Identifiers for PSMB9 Gene

  • GC06P032818
  • GC06P032582
  • GC06P032868
  • GC06P032929
  • GC06P032812
  • GC06P032815
  • GC06P032821

Summaries for PSMB9 Gene

Entrez Gene Summary for PSMB9 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. [provided by RefSeq, Mar 2010]

GeneCards Summary for PSMB9 Gene

PSMB9 (Proteasome Subunit Beta 9) is a Protein Coding gene. Diseases associated with PSMB9 include Eosinophilic Variant Of Chromophobe Renal Cell Carcinoma and Nasopharyngeal Disease. Among its related pathways are RET signaling and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB6.

UniProtKB/Swiss-Prot for PSMB9 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.

Gene Wiki entry for PSMB9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB9 Gene

Genomics for PSMB9 Gene

Regulatory Elements for PSMB9 Gene

Enhancers for PSMB9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F032851 1.3 FANTOM5 ENCODE 33.1 +9.8 9771 5.2 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 PSMB9 TAP1 BRD2 RING1 VPS52 ZBTB12 LEMD2 EHMT2 PSMB8 MIR5004
GH06F032860 1.1 Ensembl ENCODE 30.3 +17.2 17206 1.2 PKNOX1 SIN3A THRB RAD21 RFX5 SCRT2 ZNF143 ZNF263 CEBPB IKZF1 PSMB9 TAP1 HLA-DQB1 HLA-DQA1 GC06P032876
GH06F032866 1.3 FANTOM5 Ensembl ENCODE 20.9 +23.5 23496 1.7 CTCF IRF2 PKNOX1 SAP130 GTF2E2 RAD21 RFX5 RELA ZFHX2 POLR2A PSMB9 PSMB8-AS1 PSMB8 TAP1 TAP2 BRD2 GC06P032876
GH06F032893 0.9 Ensembl ENCODE 20.3 +51.2 51165 3.8 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF263 SP3 SP5 BRD2 DAXX MIR6873 ATF6B LEMD2 ITPR3 RGL2 VPS52 PSMB9 HLA-DMA
GH06F032940 1.4 FANTOM5 ENCODE 19.5 +100.1 100061 8.8 HDGF ATF1 WRNIP1 SIN3A ARID4B BRCA1 ZNF2 YY1 ZNF143 ZNF207 HLA-DMA BRD2 PSMB9 TAP1 TAP2 HLA-DMB BRD2-IT1 HLA-DPA1 ENSG00000250264 MIR6873
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PSMB9 on UCSC Golden Path with GeneCards custom track

Promoters for PSMB9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000025364 264 2801 HDGF ATF1 WRNIP1 SIN3A ARID4B DMAP1 BRCA1 YY1 ZNF143 ZNF263

Genomic Location for PSMB9 Gene

Chromosome:
6
Start:
32,844,136 bp from pter
End:
32,859,851 bp from pter
Size:
15,716 bases
Orientation:
Plus strand

Genomic View for PSMB9 Gene

Genes around PSMB9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for PSMB9 Gene

  • Protein details for PSMB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28065-PSB9_HUMAN
    Recommended name:
    Proteasome subunit beta type-9
    Protein Accession:
    P28065
    Secondary Accessions:
    • B0V0T1
    • Q16523
    • Q5JNW4

    Protein attributes for PSMB9 Gene

    Size:
    219 amino acids
    Molecular mass:
    23264 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent houskeeping subunit PSMB6. Component of the spermatoproteasome, a form of the proteasome specifically found in testis. Interacts with HIV-1 TAT protein.
    Miscellaneous:
    • A model for self-activation in which residue Thr-21 serves as nucleophile and Lys-53 as proton donor/acceptor has been proposed. Subunit processing of mammalian beta-subunits proceeds via a novel ordered two-step mechanism involving autocatalysis.
    • Encoded in the MHC class II region.

    Alternative splice isoforms for PSMB9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMB9 Gene

Post-translational modifications for PSMB9 Gene

  • Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.
  • Ubiquitination at Lys 53 and Lys 215
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PSMB9 Gene

Gene Families for PSMB9 Gene

Graphical View of Domain Structure for InterPro Entry

P28065

UniProtKB/Swiss-Prot:

PSB9_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB9: view

Function for PSMB9 Gene

Molecular function for PSMB9 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component 2,beta-type subunit 2,stimulated by interferon gamma,involved in the degradation of cytoplasmic antigens for MHC class I antigen presentation pathways
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.
UniProtKB/Swiss-Prot Induction:
Up-regulated by interferon gamma (at protein level). Up-regulated by IRF1. Up-regulated by tumor necrosis factor-alpha (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohns bowel disease (CD). Up-regulated by heat shock treatment. Up-regulated by CD40L via the NFKB1 pathway in cancer cells.

Enzyme Numbers (IUBMB) for PSMB9 Gene

Gene Ontology (GO) - Molecular Function for PSMB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 14733938
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMB9: view
genes like me logo Genes that share phenotypes with PSMB9: view

Animal Models for PSMB9 Gene

MGI Knock Outs for PSMB9:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMB9 Gene

Localization for PSMB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB9 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMB9 Gene COMPARTMENTS Subcellular localization image for PSMB9 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PSMB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS 8666937
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMB9: view

Pathways & Interactions for PSMB9 Gene

SuperPathways for PSMB9 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
.78
.32
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMB9: view

Gene Ontology (GO) - Biological Process for PSMB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002376 immune system process IEA --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
genes like me logo Genes that share ontologies with PSMB9: view

No data available for SIGNOR curated interactions for PSMB9 Gene

Drugs & Compounds for PSMB9 Gene

(7) Drugs for PSMB9 Gene - From: DrugBank, ApexBio, DGIdb, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
carfilzomib Approved Pharma other, Inhibitor, Target Other, 20S Proteasome Inhibitor 0
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 794
Kyprolis Approved July 2012 Pharma 0
Celastrol Pharma Antioxidant, anti-inflammatory and immunosuppressive agent, Inhibits TNF-alpha-induced NF-kappaB activation 0
Dihydroeponemycin Pharma Proteasome inhibitor,antitumor reagent,eponemycin ddrivative 0

(4) ApexBio Compounds for PSMB9 Gene

Compound Action Cas Number
Celastrol Antioxidant, anti-inflammatory and immunosuppressive agent 34157-83-0
Dihydroeponemycin Proteasome inhibitor,antitumor reagent,eponemycin ddrivative 126463-64-7
MLN2238 β5 site of the 20S proteasome inhibitor 1072833-77-2
ONX-0914 (PR-957) Immunoproteasome inhibitor,potent and selective 960374-59-8
genes like me logo Genes that share compounds with PSMB9: view

Transcripts for PSMB9 Gene

Unigene Clusters for PSMB9 Gene

Proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB9 Gene

No ASD Table

Relevant External Links for PSMB9 Gene

GeneLoc Exon Structure for
PSMB9
ECgene alternative splicing isoforms for
PSMB9

Expression for PSMB9 Gene

mRNA expression in normal human tissues for PSMB9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSMB9 Gene

This gene is overexpressed in Whole Blood (x10.6) and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for PSMB9 Gene

This gene is overexpressed in Tlymphocyte (19.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMB9 Gene



Protein tissue co-expression partners for PSMB9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMB9 Gene:

PSMB9

SOURCE GeneReport for Unigene cluster for PSMB9 Gene:

Hs.654585
genes like me logo Genes that share expression patterns with PSMB9: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PSMB9 Gene

Orthologs for PSMB9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PSMB9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMB9 34 35
  • 99.08 (n)
dog
(Canis familiaris)
Mammalia PSMB9 34 35
  • 87.6 (n)
cow
(Bos Taurus)
Mammalia PSMB9 34 35
  • 87.21 (n)
rat
(Rattus norvegicus)
Mammalia Psmb9 34
  • 84.78 (n)
mouse
(Mus musculus)
Mammalia Psmb9 34 16 35
  • 84.47 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMB9 35
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMB9 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb9 34
  • 67 (n)
zebrafish
(Danio rerio)
Actinopterygii psmb9a 34 35
  • 66.99 (n)
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11923 34
fruit fly
(Drosophila melanogaster)
Insecta Prosbeta1 35
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pbs-1 35
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE3 35
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5051 35
  • 56 (a)
OneToMany
Species where no ortholog for PSMB9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMB9 Gene

ENSEMBL:
Gene Tree for PSMB9 (if available)
TreeFam:
Gene Tree for PSMB9 (if available)

Paralogs for PSMB9 Gene

Paralogs for PSMB9 Gene

(4) SIMAP similar genes for PSMB9 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PSMB9: view

Variants for PSMB9 Gene

Sequence variations from dbSNP and Humsavar for PSMB9 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs111240027 -- 32,854,551(+) GTCAA(C/G)GGGAA intron-variant, upstream-variant-2KB
rs111282068 -- 32,854,380(+) ATGCA(A/G)AGACC intron-variant, upstream-variant-2KB
rs111585165 -- 32,854,225(+) CCTTG(C/T)AGGGA upstream-variant-2KB, utr-variant-5-prime
rs111644712 -- 32,855,694(+) GGACC(-/A)AAAAA intron-variant, upstream-variant-2KB
rs111647750 -- 32,860,003(+) CATGA(A/T)AAATG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PSMB9 Gene

Variant ID Type Subtype PubMed ID
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv830633 CNV loss 17160897

Variation tolerance for PSMB9 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.62; 82.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMB9 Gene

Human Gene Mutation Database (HGMD)
PSMB9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMB9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMB9 Gene

Disorders for PSMB9 Gene

MalaCards: The human disease database

(7) MalaCards diseases for PSMB9 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search PSMB9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSMB9

Genetic Association Database (GAD)
PSMB9
Human Genome Epidemiology (HuGE) Navigator
PSMB9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMB9
genes like me logo Genes that share disorders with PSMB9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMB9 Gene

Publications for PSMB9 Gene

  1. Second proteasome-related gene in the human MHC class II region. (PMID: 1922385) Kelly A. … Trowsdale J. (Nature 1991) 2 3 4 22 64
  2. PSMB8 (LMP7) but not PSMB9 (LMP2) gene polymorphisms are associated to pigeon breeder's hypersensitivity pneumonitis. (PMID: 20153157) Camarena A. … Selman M. (Respir Med 2010) 3 22 46 64
  3. Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma. (PMID: 19202550) Mehta A.M. … Jan Fleuren G. (Genes Chromosomes Cancer 2009) 3 22 46 64
  4. [Allele polymorphism of genes coding proteasome subunits is associated with an enhanced risk for arterial hypertension in adolescents]. (PMID: 19526842) Goncharov S.V. … MoA-benko A.A. (Fiziol Zh 2009) 3 22 46 64
  5. Variation in HLA class I antigen-processing genes and susceptibility to human papillomavirus type 16-associated cervical cancer. (PMID: 18248301) Deshpande A. … Nolan J.P. (J. Infect. Dis. 2008) 3 22 46 64

Products for PSMB9 Gene

Sources for PSMB9 Gene

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