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PSMB8 Gene

protein-coding   GIFtS: 61

GC06M032808
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
(Previous names: proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: LMP7)
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Aliases &
Descriptions
for PSMB8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

  User Feedback
Aliases & Descriptions
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional
peptidase 7)1 2
     proteasome subunit beta type-82
RING101 2 3 5     low molecular weight protein 72
PSMB5i1 2 3     proteasome subunit beta 5i2
LMP72 3 5     protease component C132
D6S216E1 2     MGC14912
Really interesting new gene 10 protein2 3     proteasome subunit Y22
Macropain subunit C132 3     proteasome catalytic subunit 3i2
Proteasome component C132 3     proteasome-related gene 72
Multicatalytic endopeptidase complex subunit C132 3     Proteasome subunit beta-5i3
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional
protease 7)1
     EC 3.4.25.13
beta5i1     Low molecular mass protein 73
D6S2162     Y23

External Ids:    HGNC: 95451   Entrez Gene: 56962   Ensembl: ENSG000002042647   UniProtKB: P280623   

Search outside databases for aliases for PSMB8 gene

Previous GC identifers: GC06M032805 GC06M032579 GC06M032855 GC06M032916

Summaries
for PSMB8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  User Feedback		 Entrez Gene summary for PSMB8:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core
structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings
are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and
cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified
proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the
proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the
class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon
and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic
processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been
identified; both isoforms are processed to yield the same mature subunit. (provided by RefSeq)

UniProtKB/Swiss-Prot: PSB8_HUMAN, P28062
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class
I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model
peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity.
Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory
response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome
deficiency

Gene Wiki entry for PSMB8

Genomic Views
for PSMB8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
About This Section

  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the PSMB8 gene upstream (promoter) region "":
AP-1   Egr-1   STAT1   STAT1beta   STAT1alpha   NF-kappaB1   SREBP-1c   SREBP-1a   SREBP-1b   NF-kappaB   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for PSMB8:  ""
MePH08810-1A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

PSMB8 Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032808:  view genomic region     (about GC identifiers)

Start:
 32,808,494 bp from pter
End:
 32,812,712 bp from pter
Size:
 4,219 bases
Orientation:
 minus strand

6/7 alternative locations (see all 7 ):
Chr6-,ALT_REF_LOCI_6 32,737,204-32,777,005      Chr6-,ALT_REF_LOCI_5 32,841,974-32,846,184      Chr6-,ALT_REF_LOCI_4 32,962,293-32,966,513     
Chr6-,ALT_REF_LOCI_3 32,786,475-32,801,733      Chr6-,ALT_REF_LOCI_7 32,898,409-32,902,629      Chr6-,ALT_REF_LOCI_2 32,730,817-32,774,225     
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
NT_167249.1  

Proteins
for PSMB8 gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

  User Feedback		 UniProtKB/Swiss-Prot: PSB8_HUMAN, P28062 (See protein sequence)
Recommended Name: Proteasome subunit beta type-8 precursor  
Size: 276 amino acids; 30354 Da
Subunit: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core
is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two
end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.
The catalytic chamber with the active sites is on the inside of the barrel. This subunit is part of the
immunoproteasome where it displaces the equivalent housekeeping subunit PSMB5. Directly interacts with POMP. Interacts
with HIV-1 TAT protein. Interacts with TAP1
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Developmental stage: Highly expressed in immature dendritic cells (at protein level)
Secondary accessions: B0UZC0 Q29824 Q5JNW6 Q96J48
Alternative splicing: 2 isoforms:  P28062-1   P28062-2   (Additional isoforms seem to exist)

Post-translational modifications:

  • Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic
    • activity (By similarity)1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_004150.1  NP_683720.2  


    ENSEMBL proteins: 
    ENSP00000378748 ENSP00000364015 ENSP00000364016 


    Human Recombinant Proteins 
    ""Browse Purified and Recombinant Proteins at Millipore
    ""Browse Human Recombinant Proteins at Sigma-Aldrich
    "" Browse R&D Systems for human recombinant proteins
    ""Enzo Life Sciences proteins for PSMB8
    ""HuPro® and/or Recombinant Proteins from Abnova for PSMB8 ""
    "" Origene Purified Recombinant Human Proteins (see all 2): PSMB8
    ""Novus Biologicals Proteins for PSMB8  ""
    Novus Biologicals Lysates for PSMB8
    ""Browse Sino Biological Recombinant Proteins  ""

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502 proteasome complex TAS8666937
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    GO:0005839 proteasome core complex IEA--
    About this table

    "" PSMB8 for ontologies           About GeneDecksing



    Antibodies for PSMB8: 
    ""Millipore Mono- and Polyclonal Antibodies for the study of PSMB8
    ""Sigma-Aldrich Antibodies for PSMB8
    "" Browse R&D Systems for Antibodies
    ""Monoclonal and Polyclonal Antibodies from Abnova (PSMB8)
    ""Browse Origene Antibodies ""
    ""Novus Biologicals Antibodies for PSMB8
    ""Browse antibodies at Epitomics

    Assays for PSMB8: 
    ""Browse Kits and Assays available from Millipore
    ""Browse ELISAs at Sigma-Aldrich
    "" Browse R&D Systems for biochemical assays
    ""Enzo Life Sciences assays for PSMB8

    Protein Domains/
    Families
    for PSMB8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

      User Feedback
    "" PSMB8 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001353 Proteasome_sua/b
     IPR016050 Proteasome_bsu_CS
     IPR000243 Pept_T1A_subB

    Graphical View of Domain Structure for InterPro Entry P28062

    ProtoNet protein and cluster: P28062

    1 Blocks protein family: IPB000243 Proteasome B-type subunit

    UniProtKB/Swiss-Prot: PSB8_HUMAN, P28062
    Similarity: Belongs to the peptidase T1B family

    Gene Function
    for PSMB8 gene

    (According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (PSMB8)
    "" Origene 29mer shRNA kits in GFP-retroviral vector (see all 2): PSMB8
    Origene shRNA RFP (see all 2): PSMB8
    Origene basic RS shRNA (see all 2): PSMB8

    ""Applied Biosystems Silencer® siRNAs for PSMB8
    ""Sigma-Aldrich siRNA Panels and siRNA for PSMB8
    Sigma-Aldrich shRNA Panels and shRNA for PSMB8
    Explore Sigma-Aldrich super-pooled esiRNAs
    Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    ""Browse iPSC Reprogramming Factors at Sigma-Aldrich
    "" Origene GFP tagged cDNA clones in CMV expression vector (see all 2): PSMB8
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PSMB8
    Origene untagged cDNA clones in CMV expression vector (see all 3): PSMB8
    ""Browse Sino Biological Human cDNA Clones  ""

    UniProtKB/Swiss-Prot: PSB8_HUMAN, P28062
    Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
    peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
    proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class
    I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model
    peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity.
    Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory
    response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome
    deficiency
    Catalytic activity: Cleavage of peptide bonds with very broad specificity
    Induction: Up-regulated by interferon gamma and IRF1 (at protein level). Up-regulated by tumor necrosis factor-alpha
    (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohn's bowel disease (CD).
    Down-regulated by the selective inhibitor PR-957. Down-regulated in mature dendritic cells by herpes simplex virus
    type I infection. Up-regulated by heat shock treatment
    Enzyme Number (IUBMB): EC 3.4.25.1 

    Genatlas biochemistry entry for PSMB8:
    multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component 7,beta-type subunit,stimulated by
    interferon gamma,involved in the degradation of cytoplasmic antigens for MHC class I antigen presentation pathways

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004175 endopeptidase activity ----
    GO:0004298 threonine-type endopeptidase activity IEA--
    GO:0005515 protein binding IPI15231747
    GO:0008233 peptidase activity IEA--
    About this table

    "" PSMB8 for ontologies           About GeneDecksing

    Animal Models: 3 MGI mutant phenotypes (inferred from 1 allele"") (MGI details for Psmb8):

    hematopoietic systemimmune systemtumorigenesis

    "" PSMB8 for phenotypes           About GeneDecksing

    Pathways & Interactions
    for PSMB8 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
    About This Section

      User Feedback
    "" PSMB8 for pathways           About GeneDecksing

    1 "" Millipore Pathway for PSMB8
      ""  Immune response Antigen presentation by MHC class I

    3 "" Sigma-Aldrich "Your Favorite Gene" Pathways for  PSMB8  (Your Favorite Gene powered by Ingenuity)
      ""  Protein Ubiquitination Pathway
    Antigen Presentation Pathway
    Interferon Signaling

    5/13 "" GeneAssist Pathways for PSMB8 (see all 13 )
      ""  Presenilin-Mediated Signaling
    CDK5 Pathway
    SMAD Signaling Network
    Chks in Checkpoint Regulation
    ER-Mediated Phagocytosis

    1 "" Kegg Pathway  (Kegg details for PSMB8):
      ""  hsa03050 Proteasome

    "" SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PSMB8

    3 Interacting proteins for PSMB8 (ENSP000003640163 P280621) via UniProtKB, MINT, and/or STRING ""
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LSM1O151161EBI-372294,EBI-347619
    PSMB1ENSP000002621933STRING: ENSP00000262193
    PSMB7ENSP000002594573STRING: ENSP00000259457
    About this table

    5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955 immune response IEA--
    GO:0019882 antigen processing and presentation ----
    GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process EXP11285280
    GO:0044419 interspecies interaction between organisms IEA--
    GO:0051436 negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle EXP15029244
    About this table

    "" PSMB8 for ontologies           About GeneDecksing


    Drugs & Compounds
    for PSMB8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

      User Feedback
    "" PSMB8 for compounds           About GeneDecksing

    "" Enzo Life Sciences drugs & compounds for PSMB8
    ""Browse Small Molecules at Sigma-Aldrich

    "" Browse Tocris compounds for PSMB8
    10/31 ""Novoseek chemical compound relationships for PSMB8 gene (see all 31 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    npys 11.36 4 12710532 (2), 9802414 (1), 16873543 (1)
    bibp3226 9.41 4 9802414 (1), 9452185 (1), 9203528 (1), 11108796 (1)
    lactacystin 4.77 3 10358150 (2), 11159003 (1)
    d-amino acid 4.25 3 8795076 (3)
    sr 120819a 3.65 1 11108796 (1)
    biie-0246 2.31 1 11108796 (1)
    benextramine 2.08 1 8474004 (1)
    methylchloride 1.55 1 9746558 (1)
    leukotriene b4 0.99 2 12475980 (2)
    matrigel 0.70 1 16891622 (1)
    About this table


    Transcripts
    for PSMB8 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
    Expression Assays from Applied Biosystems)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (PSMB8)
    ""Applied Biosystems Silencer® siRNAs:  NM_004159  NM_148919  
    "" Origene 29mer shRNA kits in GFP-retroviral vector (see all 2): PSMB8
    Origene shRNA RFP (see all 2): PSMB8
    Origene basic RS shRNA (see all 2): PSMB8

    ""Sigma-Aldrich siRNA Panels and siRNA for PSMB8
    Sigma-Aldrich shRNA Panels and shRNA for PSMB8
    Explore Sigma-Aldrich super-pooled esiRNAs

    microRNA:""Search SABiosciences for microRNAs that regulate PSMB8: ""
    Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
    NM_004159  NM_148919  


    Clones:"" Origene GFP tagged cDNA clones in CMV expression vector (see all 2): PSMB8
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PSMB8
    Origene untagged cDNA clones in CMV expression vector (see all 3): PSMB8
    Primers:"" Origene genome-wide validated SYBR primer pairs: PSMB8
    ""SABiosciences RT2 qPCR Primer Assay for PSMB8: PPH13734A ""

    REFSEQ mRNAs for PSMB8 gene (2 alternative transcripts): 

    NM_004159.4  NM_148919.3  

    Additional cDNA sequence: 

    AK300962.1 BC001114.2 CR541661.1 CR591946.1 CR595654.1 CR596244.1 CR606312.1 CR621259.1 
    CR621302.1 U17496.1 U17497.1 X62598.1 

    17 DOTS entries:

    DT.75168817  DT.100814840  DT.100814835  DT.92471432  DT.100889868  DT.100037665  DT.121353399  DT.95185222 
    DT.121353481  DT.95161041  DT.95185220  DT.95352469  DT.100037667  DT.121353467  DT.95185219  DT.97862526 
    DT.99951788 

    24/479 AceView cDNA sequences (see all 479 ):

    AI870930 CA430061 BF590563 AA100479 CR621259 BM781476 BM549227 AW445180 
    BG108416 BQ946144 BU196748 BM845490 BE646272 AI417902 BM823136 CR596244 
    BQ954940 AI718891 AI368069 AA514303 BU951889 BM781508 BC001114 BI254833 

    "" highest scoring ESTs for PSMB8:

    AA147133 AA149010 AA307721 AA471233 AW630400 BC001114 BE274450 BE384425 BE384467 BE392703 

    Unigene Cluster for PSMB8:

    Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
    Hs.180062  [show with all ESTs]
    Unigene Representative Sequence: NM_004159


    GeneLoc Exon Structure

    5 Ensembl transcripts including schematic representations:
    ENST00000490613  ENST00000395339  ENST00000484003  ENST00000374881  ENST00000374882  

    Expression
    for PSMB8 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
    About This Section

      User Feedback

    PSMB8 expression in normal and diseased human tissues

    "" Applied Biosystems TaqMan ® Gene Expression Assays for PSMB8

    1""  / 2""  / 3""

    3 probe-sets matching PSMB8 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    41184_s_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 X87344 0.20 1.00 0.72 1
    209040_s_at2, 3 U133-A 1 1.00 1.00 -- -- U17496 0.60 1.00 0.82 1
    209040_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    "" PSMB8 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AAGGAAGATG

    SOURCE GeneReport for Unigene cluster: Hs.180062

    Expression variation in blood from EXPOLDB for PSMB8

    Primers:"" Origene genome-wide validated SYBR primer pairs: PSMB8 ""
    ""SABiosciences RT2 qPCR Primer Assay for PSMB8: PPH13734A ""

    Orthologs
    for PSMB8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

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    Orthologs for PSMB8 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 PSMB81   -- proteasome (prosome, macropain) subunit, beta type, more 87.08(n)
    85.14(a)    		 474865  XM_532100.2  XP_532100.1 
    chimpanzee
    (Pan troglodytes)    		 PSMB81   -- proteasome (prosome, macropain) subunit, beta type, more 98.91(n)
    98.91(a)    		 746418  XM_001167272.1  XP_001167272.1 
    cow
    (Bos taurus)    		 PSMB81   -- proteasome (prosome, macropain) subunit, beta type, more 87.2(n)
    88.77(a)    		 282013  NM_001040480.1  NP_001035570.1 
    rat
    (Rattus norvegicus)    		 Psmb81   -- proteasome (prosome, macropain) subunit, beta type more 85.28(n)
    93.2(a)    		 24968  NM_080767.1  NP_542945.1 
    mouse
    (Mus musculus)    		 Psmb81, 5 17 (18.61 cM)5
    		 proteasome (prosome, macropain) subunit, beta type more1, 5 83.88(n)1
    89.01(a)1    		 169131  NM_010724.11  NP_034854.11 
     AF0278655  AI3857185  (see all 24)
    About this table        Species with no ortholog for PSMB8

    ENSEMBL Gene Tree for PSMB8

    Paralogs
    for PSMB8 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      User Feedback
    Paralogs for PSMB8 gene
    PSMB52  PSMB112  

    "" PSMB8 for paralogs           About GeneDecksing


    Genomic Variants
    for PSMB8 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
    About This Section

      User Feedback
    10/13 NCBI SNPs in PSMB8 are shown (see all 13 )
    (Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 121)
    ABGenomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    ""
    rs32001581,2
    		C,F32792303(-) GAGGTC/TTTGGC 2 -- ut31""1Minor allele frequency- T:0.04WA 50""
    --
    rs93571551,2
    		C,F32552054(+) TGATGG/AGAAAC 2 -- int1""16Minor allele frequency- A:0.13NS EA NA WA 1630""
    ""
    rs605070221,2
    		C,F32551788(+) TATGAG/TACATA 2 -- int1""2Minor allele frequency- T:0.03NA WA 122""
    --
    rs20716271,2
    		C,F32551429(-) AGCCTG/TGCCAA 2 -- int1""1Minor allele frequency- T:0.27EA 1300""
    --
    rs557451251,2
    		C,F32551125(+) CATGCG/ACAAGC 2 -- int1""1Minor allele frequency- A:0.02EA 88""
    --
    rs20714641,2
    		C32551282(-) GATGGC/TGCCAC 2 -- int1""0--------
    --
    rs561386421,2
    		--32792227(+) AGCCCA/GTACTC 2 -- ut31""0--------
    --
    rs558530411,2
    		--32792956(+) TGGCAC/TAAGCA 4 Y C ref1 mis1""0--------
    --
    rs559518251,2
    		--32551417(+) GGTTTC/TGCCAT 2 -- int1""0--------
    --
    rs561024491,2
    		--32551480(+) CTCCTC/TCCAGG 2 -- int1""0--------
    About this table

    HapMap Linkage Disequilibrium images for PSMB8 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
          Database of Genomic Variants (DGV) variations for PSMB8: --

    Disorders & Mutations
    for PSMB8 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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    "" PSMB8 for disorders           About GeneDecksing

    OMIM: 177046

    10/66 ""Novoseek disease relationships for PSMB8 gene (see all 66 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    diabetes mellitus insulin-dependent 4.45 11 9000709 (4), 7847389 (3), 11793848 (2), 9599304 (1) (see all 5)
    cervical cancer 2.97 7 17366619 (3), 19202550 (2), 18248301 (1), 17622526 (1)
    regressing melanoma 2.88 1 12883363 (1)
    esophageal cancer 2.72 5 15774487 (5)
    class i; histocompatibility complex 2.36 2 15907481 (1), 15104675 (1)
    class ii; histocompatibility complex 2.33 2 8458375 (1), 8383129 (1)
    colorectal tumor 2.08 2 15104675 (2)
    renal cell adenoma 1.99 1 14713847 (1)
    hyperphagia 1.83 2 16873543 (2)
    ankylosing spondylitis 1.61 3 10431052 (2), 19404951 (1)
    About this table

    Human Gene Mutation Database: PSMB8
    Genetic Association Database: PSMB8
    Human Genome Epidemiology Navigator: PSMB8 (27 documents)

    Medical News
    for PSMB8 gene

    (Possibly Related Articles in Doctor's Guide)
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    Publications
    for PSMB8 gene

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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      User Feedback    		10/193 PubMed articles for PSMB8 gene (see all 193 ):

    Search for PSMB8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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    OMIM
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    Genome Databases showing PSMB8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5696 HGNC: 9545 AceView: PSMB8 Ensembl:ENSG00000204264 euGenes: HUgn5696
    ECgene: PSMB8 Kegg: 5696 H-InvDB: PSMB8

    Other Databases showing PSMB8 gene

    (According to HUGE)
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    Specialized Databases showing PSMB8 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    Intellectual Property
    for PSMB8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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      User Feedback    		Patent Information for PSMB8 gene: ""
    Search GeneIP for patents involving PSMB8

    GeneCards and IP: ""
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    Services
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    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
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    Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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    Products for PSMB8:
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    "" Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
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