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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PSMB8 Gene

protein-coding   GIFtS: 69
GCID: GC06M032808

Proteasome (Prosome, Macropain) Subunit, Beta Type, 8

(Previous names: proteasome (prosome, macropain) subunit, beta type, 8 (large...)
(Previous symbol: LMP7)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Proteasome (Prosome, Macropain) Subunit, Beta Type, 81 2     D6S216E2
LMP71 2 3 5     JMP2
RING102 3 5     NKJO2
Large Multifunctional Peptidase 71 2     Low Molecular Weight Protein 72
Low Molecular Mass Protein 72 3     Protease Component C132
Macropain Subunit C132 3     Proteasome (Prosome, Macropain) Subunit, Beta Type, 8 (Large
Multifunctional Peptidase 7)2
Multicatalytic Endopeptidase Complex Subunit C132 3     Proteasome Catalytic Subunit 3i2
Proteasome Component C132 3     Proteasome Subunit Beta 5i2
Really Interesting New Gene 10 Protein2 3     Proteasome Subunit Beta Type-82
PSMB5i2 3     Proteasome Subunit Y22
EC 3.4.25.13 8     Proteasome-Related Gene 72
Proteasome (Prosome, Macropain) Subunit, Beta Type, 8 (Large
Multifunctional Protease 7)1
     Y23
ALDD2     Proteasome Subunit Beta-5i3
D6S2162     

External Ids:    HGNC: 95451   Entrez Gene: 56962   Ensembl: ENSG000002042647   OMIM: 1770465   UniProtKB: P280623   

Export aliases for PSMB8 gene to outside databases

Previous GC identifers: GC06M032805 GC06M032579 GC06M032855 GC06M032916


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PSMB8 Gene:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The
core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and
2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high
concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential
function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene
encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit.
This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this
gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5
subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two
alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same
mature subunit. (provided by RefSeq, Jul 2008)

GeneCards Summary for PSMB8 Gene: 
PSMB8 (proteasome (prosome, macropain) subunit, beta type, 8) is a protein-coding gene. Diseases associated with PSMB8 include nakajo nishimura syndrome, and jmp syndrome, and among its related super-pathways are Regulation of APC/C activators between G1/S and early anaphase and Mitotic Anaphase. GO annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB5.

UniProtKB/Swiss-Prot: PSB8_HUMAN, P28062
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate
class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave
model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced
sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved
in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results
in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes

Gene Wiki entry for PSMB8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NT_167245.1  NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167244.1  NT_167246.1  NT_167247.1  
NT_167248.1  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PSMB8 gene promoter:
         STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PSMB8 promoter sequence
   Search SABiosciences Chromatin IP Primers for PSMB8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSMB8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

PSMB8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMB8 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032808:  view genomic region     (about GC identifiers)

Start:
32,808,494 bp from pter      End:
32,812,712 bp from pter
Size:
4,219 bases      Orientation:
minus strand

6/7 alternative locations (see all 7):
Chr6-,NT_167244 4,095,498-4,099,716      Chr6-,NT_167245 4,089,872-4,094,090      Chr6-,NT_113891.2 4,253,022-4,257,240     
Chr6-,NT_167246 4,265,690-4,269,908      Chr6-,NT_167248 4,040,601-4,044,819      Chr6-,NT_167247 4,145,371-4,149,579     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PSB8_HUMAN, P28062 (See protein sequence)
Recommended Name: Proteasome subunit beta type-8 precursor  
Size: 276 amino acids; 30354 Da
Subunit: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome
core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure.
The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven
beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. This subunit is part
of the immunoproteasome where it displaces the equivalent housekeeping subunit PSMB5. Component of the
spermatoproteasome, a form of the proteasome specifically found in testis. Directly interacts with POMP.
Interacts with HIV-1 TAT protein. Interacts with TAP1
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Developmental stage: Highly expressed in immature dendritic cells (at protein level)
Secondary accessions: B0UZC0 Q29824 Q5JNW6 Q5QNR8 Q96J48
Alternative splicing: 2 isoforms:  P28062-1   P28062-2   (Contains a phosphothreonine at position 5)

Explore the universe of human proteins at neXtProt for PSMB8: NX_P28062

Explore proteomics data for PSMB8 at MOPED 

Post-translational modifications:

  • UniProtKB: Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile
    proteolytic activity (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P28062

  • 4 DME Specific Peptides for PSMB8 (P28062)
     KVIEINP  HGTTTLAF  ISVSAASK  GPGLYYVD 

    PSMB8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PSMB8 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_004150.1  NP_683720.2  

    ENSEMBL proteins: 
     ENSP00000378748   ENSP00000364016   ENSP00000364015  
    Reactome Protein details: P28062
    Human Recombinant Protein Products for PSMB8: 
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    OriGene Protein Over-expression Lysate for PSMB8
    OriGene MassSpec for PSMB8 
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    Novus Biologicals PSMB8 Proteins
    Novus Biologicals PSMB8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PSMB8
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex TAS8666937
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0005839proteasome core complex ISS--
    GO:1990111spermatoproteasome complex ISS--

    PSMB8 for ontologies           About GeneDecksing



    PSMB8 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PSMB8
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    OriGene Antibodies for PSMB8
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    Novus Biologicals PSMB8 Antibodies
    Abcam antibodies for PSMB8
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    LSBio Antibodies in human, mouse, rat for PSMB8 

    Assay Products for PSMB8: 
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PSMB8
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PSM: Proteasome (prosome, macropain) subunits

    4 InterPro protein domains:
     IPR001353 Proteasome_sua/b
     IPR016050 Proteasome_bsu_CS
     IPR000243 Pept_T1A_subB
     IPR023333 Proteasome_suB-type

    Graphical View of Domain Structure for InterPro Entry P28062

    ProtoNet protein and cluster: P28062

    1 Blocks protein domain: IPB000243 Proteasome B-type subunit

    UniProtKB/Swiss-Prot: PSB8_HUMAN, P28062
    Similarity: Belongs to the peptidase T1B family


    PSMB8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PSB8_HUMAN, P28062
    Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
    peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
    proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate
    class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave
    model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced
    sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved
    in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results
    in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes
    Catalytic activity: Cleavage of peptide bonds with very broad specificity
    Induction: Up-regulated by IFNG/IFN-gamma and IRF1 (at protein level). Up-regulated by TNF (at protein level).
    Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohn's bowel disease (CD). Down-regulated by
    the selective inhibitor PR-957. Down-regulated in mature dendritic cells by HSV-1 infection. Up-regulated by heat
    shock treatment

         Genatlas biochemistry entry for PSMB8:
    multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component 7,beta-type subunit,stimulated by
    interferon gamma,involved in the degradation of cytoplasmic antigens for MHC class I antigen presentation
    pathways

         Enzyme Number (IUBMB): EC 3.4.25.11 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004298threonine-type endopeptidase activity IEA--
    GO:0005515protein binding IPI15303969
         
    PSMB8 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PSMB8:
     Decreased Salmonella enterica   Increased cell death HMECs cel 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Psmb8):
     hematopoietic system  immune system  tumorigenesis 

    PSMB8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Psmb8tm1Hjf for PSMB8

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PSMB8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PSMB8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PSMB8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PSMB8 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSMB8
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate PSMB8:
    hsa-miR-125a-5p hsa-miR-125b hsa-miR-451 hsa-miR-1912 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidPSMB8 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PSMB8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSMB8

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of PSMB8

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PSMB8 (NM_004159)
    Sino Biological Human cDNA Clone for PSMB8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSMB8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMB8
    Sirion Biotech Customized lentivirus for stable overexpression of PSMB8 
                         Customized lentivirus expression plasmids for stable overexpression of PSMB8 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMB8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PSMB8 About   (see all 26)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    APC/C:Cdc20 mediated degradation of mitotic proteins0.94
    Removal of licensing factors from origins0.89
    Cdc20:Phospho-APC/C mediated degradation of Cyclin A0.94
    Regulation of DNA replication0.89
    CDK-mediated phosphorylation and removal of Cdc60.94
    Cyclin E associated events during G1/S transition 0.89
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    Switching of origins to a post-replicative state0.89
    2M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    3Chks in Checkpoint Regulation
    Chks in Checkpoint Regulation0.59
    SREBP Proteolysis0.43
    G2-M Phase Transition0.59
    DNA Repair Mechanisms0.32
    Estrogen-mediated S-Phase Entry0.55
    4Metabolism of mRNA
    Metabolism of RNA0.92
    Metabolism of mRNA0.92
    5Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PSMB8
        Immune response Antigen presentation by MHC class I

    5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PSMB8 (see all 12)
        CDK5 Pathway
    SOCS Pathway
    SMAD Signaling Network
    Estrogen-mediated S-Phase Entry
    G2-M Phase Transition

    1 GeneGo (Thomson Reuters) Pathway for PSMB8
        Immune response Antigen presentation by MHC class I

    1 BioSystems Pathway for PSMB8
        Proteasome Degradation


    5/77        Reactome Pathways for PSMB8 (see all 77)
        Orc1 removal from chromatin
    CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway
    CDT1 association with the CDC6:ORC:origin complex
    Autodegradation of the E3 ubiquitin ligase COP1


    1         Kegg Pathway  (Kegg details for PSMB8):
        Proteasome


    PSMB8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PSMB8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for PSMB8 (P280621, 3 ENSP000003640164) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206235Q035193I2D: score=3 
    ENSG00000206299Q035193I2D: score=3 
    ENSG00000223481Q035193I2D: score=3 
    ENSG00000225967Q035193I2D: score=3 
    ENSG00000228582Q035193I2D: score=3 
    About this table

    Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--

    PSMB8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PSMB8 for compounds           About GeneDecksing

    EMD Millipore small molecules for PSMB8:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PSMB8 (PSB8)

    1 Novoseek inferred chemical compound relationship for PSMB8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 0 5 7521687 (3), 15501285 (1)

    Search CenterWatch for drugs/clinical trials and news about PSMB8 / PSB8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PSMB8 gene (2 alternative transcripts): 
    NM_004159.4  NM_148919.3  

    Unigene Cluster for PSMB8:

    Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
    Hs.180062  [show with all ESTs]
    Unigene Representative Sequence: NM_004159
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490613 ENST00000395339 ENST00000374882(uc003oce.3 uc011dqh.2)
    ENST00000374881(uc003ocf.3) ENST00000484003
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate PSMB8:
    hsa-miR-125a-5p hsa-miR-125b hsa-miR-451 hsa-miR-1912 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidPSMB8 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSMB8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMB8
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSMB8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSMB8

    Additional mRNA sequence: 

    BC001114.2 CR541661.1 U17496.1 U17497.1 X62598.1 

    17 DOTS entries:

    DT.75168817  DT.100814840  DT.92471432  DT.100814835  DT.100889868  DT.100037665  DT.121353399  DT.95185222 
    DT.121353481  DT.95161041  DT.95185220  DT.95352469  DT.100037667  DT.121353467  DT.95185219  DT.97862526 
    DT.99951788 

    24/479 AceView cDNA sequences (see all 479):

    BM979251 AI708880 AW452170 BM781620 AI278959 BQ009886 BQ954940 CR596244 
    BE395679 BI909947 W73244 BQ643430 BM781473 BX331156 BI254833 BU540527 
    BM781493 AI334968 BM916919 BM760476 BQ064245 NM_148919 BQ316737 BQ687922 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PSMB8 expression in normal human tissues (normalized intensities)      PSMB8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGAAGATG
    PSMB8 Expression
    About this image


    PSMB8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Thymus (Hematopoietic System)
             Thymus
     
     Blood Brain Barrier (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Cells Epiblast
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow

    See PSMB8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PSMB8

    SOURCE GeneReport for Unigene cluster: Hs.180062
        SABiosciences Custom PCR Arrays for PSMB8
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PSMB8 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Psmb81 , 5 proteasome (prosome, macropain) subunit, beta type more1, 5 84.06(n)1
    89.05(a)1
      17 (17.98 cM)5
    169131  NM_010724.21  NP_034854.21 
     341977215 
    lizard
    (Anolis carolinensis)
    Reptilia PSMB86
    Proteasome subunit beta type
    71(a)
    1 ↔ 1
    GL344036.1(27859-39727)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.1622 Xenopus laevis mRNA for low molecular mass protein-7 more 79.47(n)    BC060388.1 
    zebrafish
    (Danio rerio)
    Actinopterygii psmb82 proteasome (prosome, macropain) subunit, beta type, more 77.24(n)   30666  AF032390.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pros&bgr;53 proteasome endopeptidase 52(a)
    (best of 2)
      47C1   --
    worm
    (Caenorhabditis elegans)
    Secernentea pbs-56
    Protein PBS-5
    38(a)
    1 → many
    I(14718992-14720482)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRE26
    Beta 5 subunit of the 20S proteasome, responsible ...
    46(a)
    1 → many
    XVI(732349-733212)


    ENSEMBL Gene Tree for PSMB8 (if available)
    TreeFam Gene Tree for PSMB8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PSMB8 gene
    PSMB52  PSMB112  
    3 SIMAP similar genes for PSMB8 using alignment to 4 protein entries:     PSB8_HUMAN (see all proteins):
    PSMB5    PSMB11    PSMB6

    PSMB8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/111 SNPs in PSMB8 are shown (see all 111)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0664494
    Nakajo syndrome (NKJO)4--see VAR_0664492 G V mis40--------
    VAR_0652914
    Nakajo syndrome (NKJO)4--see VAR_0652912 T M mis40--------
    VAR_0652044
    ----see VAR_0652042 Q K mis40--------
    VAR_0064884
    ----see VAR_0064882 G R mis40--------
    rs1886328801,2
    C--32724209(+) ATTCAA/GTATCC 2 -- ds50010--------
    rs1932739801,2
    --32724250(+) GGTATA/GGTGTT 2 -- ds50010--------
    rs1167384501,2
    C,F--32724281(+) GTGAAG/ATGGAA 2 -- ds50011Minor allele frequency- A:0.02WA 118
    rs37633491,2
    C,F,A,H--32724368(-) GTGTGT/CTCCAT 2 -- ds500126Minor allele frequency- C:0.49EA NS WA NA CSA 4232
    rs455062011,2
    C,F--32724435(+) CAAGTG/ATCCAT 2 -- ds50011Minor allele frequency- A:0.07NA 120
    rs1120801821,2
    C--32724595(+) ACAACC/AACAGG 2 -- ds50011Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for PSMB8 (32808494 - 32812712 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PSMB8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830633CNV Loss17160897


    Human Gene Mutation Database (HGMD): PSMB8
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PSMB8
    DNA2.0 Custom Variant and Variant Library Synthesis for PSMB8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 177046    OMIM disorders: --

    UniProtKB/Swiss-Prot: PSB8_HUMAN, P28062
  • Nakajo syndrome (NKJO) [MIM:256040]: An autosomal recessive autoinflammatory disorder characterized by
    early childhood onset of recurrent fever, joint stiffness and severe contractures of the hands and feet, and
    erythematous skin lesions with subsequent development of lipodystrophy and laboratory evidence of immune
    dysregulation. Accompanying features may include muscle weakness and atrophy, hepatosplenomegaly, and microcytic
    anemia. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Note=Mutation Met-75 has been found in chronic atypical neutrophilic dermatosis with lipodystrophy and
    elevated temperature syndrome (CANDLE syndrome). CANDLE patients have some overlapping features with NKJO
    patients, including a cutaneous eruption and lipodystrophy. They show a characteristic neutrophilic dermatosis
    with a mononuclear interstitial infiltrate in the dermis that seems pathognomonic for CANDLE syndrome
    (PubMed:21953331)

  • 20/72 diseases for PSMB8 (see all 72):    About MalaCards
    nakajo nishimura syndrome    jmp syndrome    autoinflammation, lipodystrophy, and dermatosis syndrome    nakajo syndrome
    chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature    cardiac sarcoidosis    panniculitis    brucellosis
    microcytic anemia    lymphocytic choriomeningitis    lipodystrophy    fibromyalgia
    nephroblastoma    hepatitis b virus infection    sarcoidosis    ankylosing spondylitis
    esophagitis    vitiligo    spondylitis    type 1 diabetes mellitus

    3 diseases from the University of Copenhagen DISEASES database for PSMB8:
    JMP syndrome     Panniculitis     Lipodystrophy

    PSMB8 for disorders           About GeneDecksing

    10/16 Novoseek inferred disease relationships for PSMB8 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma renal cell 30.7 1 11059775 (1)
    tumors 28.9 14 12694570 (2), 10874472 (1), 9815722 (1), 19492245 (1) (see all 11)
    colorectal tumors 26.7 2 15104675 (2)
    lung carcinoma 24.9 1 8803612 (1)
    hashimotos thyroiditis 24.8 1 9599304 (1)
    diabetes mellitus insulin-dependent 22.4 3 9599304 (1), 7847389 (1), 11793848 (1)
    graves disease 12.4 1 9599304 (1)
    carcinoma squamous cell 9.86 1 11162627 (1)
    cancer 5.62 2 16855371 (1), 15814633 (1)
    primary tumor 4.01 2 19243813 (1), 15897905 (1)

    Genetic Association Database (GAD): PSMB8
    Human Genome Epidemiology (HuGE) Navigator: PSMB8 (36 documents)

    Export disorders for PSMB8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PSMB8 gene, integrated from 9 sources (see all 227):
    (articles sorted by number of sources associating them with PSMB8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PSMB8 (LMP7) but not PSMB9 (LMP2) gene polymorphisms are associated to pigeon breeder's hypersensitivity pneumonitis. (PubMed id 20153157)1, 4, 9 Camarena A....Selman M. (2010)
    2. Relationship of large multifunctional proteasome 7 gene polymorphism with susceptibility to type 1 diabetes mellitus and DR3 gene. (PubMed id 11793848)1, 4, 9 Ding H....Yang G. (2001)
    3. Herpes simplex virus type I infection of mature dendritic cells leads to reduced LMP7-mRNA-expression levels. (PubMed id 19619915)1, 2, 9 Eisemann J....Kummer M. (2009)
    4. [The frequency of allelic polymorphism of genes encoding immunoproteasome catalytic subunits in acute coronary syndrome patients] (PubMed id 16396320)1, 4, 9 Dosenko V.E....Moibenko A.A. (2005)
    5. IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response. (PubMed id 15944226)1, 2, 9 Heink S.... Krueger E. (2005)
    6. Pharmacogenomics of responsiveness to interferon IFN-beta treatment in multiple sclerosis: a genetic screen of 100 type I interferon-inducible genes. (PubMed id 16338279)1, 4, 9 Cunningham S....Vandenbroeck K. (2005)
    7. Age dependent impact of LMP polymorphisms on TNFalpha-induced apoptosis in human peripheral blood mononuclear cells. (PubMed id 11772516)1, 4, 9 Mishto M....Franceschi C. (2002)
    8. [Involvement of TAP2 and LMP7 gene polymorphisms in HCV infection] (PubMed id 11494532)1, 4, 9 Kuzushita N....Hayashi N. (2001)
    9. Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma. (PubMed id 19202550)1, 4, 9 Mehta A.M....Jan Fleuren G. (2009)
    10. [Allele polymorphism of genes coding proteasome subun its is associated with an enhanced risk for arterial hypertension in adolescent s] (PubMed id 19526842)1, 4, 9 Honcharov S.V....MoA-benko O.O. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5696 HGNC: 9545 AceView: PSMB8 Ensembl:ENSG00000204264 euGenes: HUgn5696
    ECgene: PSMB8 Kegg: 5696 H-InvDB: PSMB8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PSMB8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PSMB8 gene:
    Search GeneIP for patents involving PSMB8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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