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Aliases for PSMB7 Gene

Aliases for PSMB7 Gene

  • Proteasome Subunit Beta 7 2 3
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 7 2 3
  • Multicatalytic Endopeptidase Complex Chain Z 3 4
  • Proteasome Subunit Z 3 4
  • Macropain Chain Z 3 4
  • EC 3.4.25.1 4 63
  • Z 3 4
  • Proteasome Catalytic Subunit 2 3
  • Protein Serine Kinase C17 3
  • Proteasome Subunit Alpha 3

External Ids for PSMB7 Gene

Previous GeneCards Identifiers for PSMB7 Gene

  • GC09M118230
  • GC09M118762
  • GC09M120569
  • GC09M122491
  • GC09M124195
  • GC09M126155
  • GC09M127115
  • GC09M096700

Summaries for PSMB7 Gene

Entrez Gene Summary for PSMB7 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMB7 Gene

PSMB7 (Proteasome Subunit Beta 7) is a Protein Coding gene. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB10.

UniProtKB/Swiss-Prot for PSMB7 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the trypsin-like activity

Gene Wiki entry for PSMB7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB7 Gene

Genomics for PSMB7 Gene

Regulatory Elements for PSMB7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PSMB7 Gene

Chromosome:
9
Start:
124,353,465 bp from pter
End:
124,415,473 bp from pter
Size:
62,009 bases
Orientation:
Minus strand

Genomic View for PSMB7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSMB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB7 Gene

Proteins for PSMB7 Gene

  • Protein details for PSMB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99436-PSB7_HUMAN
    Recommended name:
    Proteasome subunit beta type-7
    Protein Accession:
    Q99436
    Secondary Accessions:
    • B4E0P1
    • Q5TBG6
    • Q96AG8
    • Q9BWA7

    Protein attributes for PSMB7 Gene

    Size:
    277 amino acids
    Molecular mass:
    29965 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. This subunit can be displaced by the equivalent immune-specific subunit PSMB10. Interacts with HIV-1 TAT protein.

    Three dimensional structures from OCA and Proteopedia for PSMB7 Gene

    Alternative splice isoforms for PSMB7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMB7 Gene

Proteomics data for PSMB7 Gene at MOPED

Selected DME Specific Peptides for PSMB7 Gene

Post-translational modifications for PSMB7 Gene

  • Ubiquitination at Lys 31, Lys 127, Lys 225, and Lys 249
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSMB7 (PSMB7)

Domains & Families for PSMB7 Gene

Gene Families for PSMB7 Gene

Graphical View of Domain Structure for InterPro Entry

Q99436

UniProtKB/Swiss-Prot:

PSB7_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB7: view

Function for PSMB7 Gene

Molecular function for PSMB7 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta type subunit Z,30kDa,homologous of mouse Psmb7,removed from the complex by MECL1/PSMD7 after IFNG stimulation
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the trypsin-like activity

Enzyme Numbers (IUBMB) for PSMB7 Gene

Gene Ontology (GO) - Molecular Function for PSMB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IBA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 14733938
genes like me logo Genes that share ontologies with PSMB7: view
genes like me logo Genes that share phenotypes with PSMB7: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMB7

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PSMB7 Gene

Localization for PSMB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB7 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMB7 Gene COMPARTMENTS Subcellular localization image for PSMB7 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for PSMB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 17323924
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMB7: view

Pathways & Interactions for PSMB7 Gene

SuperPathways for PSMB7 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin receptor SHC signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.53
5 Immune System
genes like me logo Genes that share pathways with PSMB7: view

Gene Ontology (GO) - Biological Process for PSMB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with PSMB7: view

No data available for SIGNOR curated interactions for PSMB7 Gene

Drugs & Compounds for PSMB7 Gene

(3) Drugs for PSMB7 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other, Target Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 758
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMB7: view

Transcripts for PSMB7 Gene

Unigene Clusters for PSMB7 Gene

Proteasome (prosome, macropain) subunit, beta type, 7:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMB7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: -

Relevant External Links for PSMB7 Gene

GeneLoc Exon Structure for
PSMB7
ECgene alternative splicing isoforms for
PSMB7

Expression for PSMB7 Gene

mRNA expression in normal human tissues for PSMB7 Gene

Protein differential expression in normal tissues from HIPED for PSMB7 Gene

This gene is overexpressed in Amniocyte (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMB7 Gene



SOURCE GeneReport for Unigene cluster for PSMB7 Gene Hs.213470

mRNA Expression by UniProt/SwissProt for PSMB7 Gene

Q99436-PSB7_HUMAN
Tissue specificity: Expressed at a low level in colonic mucosa. Up-regulated in colorectal cancer tissues.
genes like me logo Genes that share expression patterns with PSMB7: view

Protein tissue co-expression partners for PSMB7 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PSMB7 Gene

Orthologs for PSMB7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMB7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMB7 35
  • 92.06 (n)
  • 95.67 (a)
PSMB7 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMB7 35
  • 91.34 (n)
  • 95.67 (a)
-- 36
  • 79 (a)
OneToMany
PSMB7 36
  • 93 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Psmb7 35
  • 90.01 (n)
  • 96.03 (a)
Psmb7 16
Psmb7 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSMB7 35
  • 99.52 (n)
  • 99.64 (a)
PSMB7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmb7 35
  • 90.25 (n)
  • 94.95 (a)
oppossum
(Monodelphis domestica)
Mammalia PSMB7 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMB7 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMB7 35
  • 76.77 (n)
  • 83.75 (a)
PSMB7 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMB7 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb7 35
  • 72.68 (n)
  • 76.9 (a)
Str.421 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3306 35
zebrafish
(Danio rerio)
Actinopterygii psmb7 35
  • 71.36 (n)
  • 79.42 (a)
psmb7 36
  • 77 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11154 35
fruit fly
(Drosophila melanogaster)
Insecta CG18341 37
  • 57 (a)
Prosbgr2 37
  • 64 (a)
Prosbeta2 35
  • 62.79 (n)
  • 67.05 (a)
Prosbeta2 36
  • 64 (a)
ManyToMany
Prosbeta2R1 36
  • 48 (a)
ManyToMany
Prosbeta2R2 36
  • 31 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011423 35
  • 63.98 (n)
  • 67.43 (a)
worm
(Caenorhabditis elegans)
Secernentea pbs-2 36
  • 41 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A02233g 35
  • 56.6 (n)
  • 56.08 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUP1 35
  • 56.12 (n)
  • 56.25 (a)
PUP1 36
  • 55 (a)
OneToMany
PUP1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PBB1 35
  • 58.17 (n)
  • 60.62 (a)
soybean
(Glycine max)
eudicotyledons Gma.5581 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6659 35
barley
(Hordeum vulgare)
Liliopsida Hv.2613 35
rice
(Oryza sativa)
Liliopsida Os.12182 35
Os05g0187000 35
  • 60.55 (n)
  • 62.11 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14021 35
corn
(Zea mays)
Liliopsida Zm.6982 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7320 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08605 35
  • 59.97 (n)
  • 62.16 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pup1 35
  • 59.26 (n)
  • 62.55 (a)
Species with no ortholog for PSMB7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMB7 Gene

ENSEMBL:
Gene Tree for PSMB7 (if available)
TreeFam:
Gene Tree for PSMB7 (if available)

Paralogs for PSMB7 Gene

Paralogs for PSMB7 Gene

(3) SIMAP similar genes for PSMB7 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PSMB7 Gene

genes like me logo Genes that share paralogs with PSMB7: view

Variants for PSMB7 Gene

Sequence variations from dbSNP and Humsavar for PSMB7 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs4574 - 124,414,882(-) AAAGG(C/T)CCGGA missense, reference
rs720540 -- 124,409,299(-) ATTGT(A/G)GGAAA intron-variant
rs912352 -- 124,399,506(+) GCAAC(A/G)GCTGT intron-variant
rs932728 -- 124,384,394(-) GAGGC(A/G)CCAGC intron-variant
rs1323760 -- 124,389,086(-) CCTTA(C/T)CCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMB7 Gene

Variant ID Type Subtype PubMed ID
nsv471322 CNV Loss 18288195
nsv519767 CNV Loss 19592680
nsv893833 CNV Gain 21882294

Variation tolerance for PSMB7 Gene

Residual Variation Intolerance Score: 44.18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.39; 94.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMB7 Gene

HapMap Linkage Disequilibrium report
PSMB7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMB7 Gene

Disorders for PSMB7 Gene

Relevant External Links for PSMB7

Genetic Association Database (GAD)
PSMB7
Human Genome Epidemiology (HuGE) Navigator
PSMB7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMB7
genes like me logo Genes that share disorders with PSMB7: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMB7 Gene

Publications for PSMB7 Gene

  1. Structural analysis and chromosomal localization of the mouse Psmb5 gene coding for the constitutively expressed beta-type proteasome subunit. (PMID: 9382924) Kohda K. … Kasahara M. (Immunogenetics 1997) 23 67
  2. The mouse genes encoding the third pair of beta-type proteasome subunits regulated reciprocally by IFN-gamma: structural comparison, chromosomal localization, and analysis of the promoter. (PMID: 9300697) Hayashi M. … Kasahara M. (J. Immunol. 1997) 23 67
  3. Structure and functions of the 20S and 26S proteasomes. (PMID: 8811196) Coux O. … Goldberg A.L. (Annu. Rev. Biochem. 1996) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for PSMB7 Gene

Sources for PSMB7 Gene

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