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Aliases for PSMB7 Gene

Aliases for PSMB7 Gene

  • Proteasome Subunit Beta 7 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 7 2 3
  • Multicatalytic Endopeptidase Complex Chain Z 3 4
  • Proteasome Subunit Z 3 4
  • Macropain Chain Z 3 4
  • EC 3.4.25.1 4 61
  • Z 3 4
  • Proteasome Catalytic Subunit 2 3
  • Proteasome Subunit Beta Type-7 3
  • Protein Serine Kinase C17 3
  • Proteasome Subunit Alpha 3

External Ids for PSMB7 Gene

Previous GeneCards Identifiers for PSMB7 Gene

  • GC09M118230
  • GC09M118762
  • GC09M120569
  • GC09M122491
  • GC09M124195
  • GC09M126155
  • GC09M127115
  • GC09M096700

Summaries for PSMB7 Gene

Entrez Gene Summary for PSMB7 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMB7 Gene

PSMB7 (Proteasome Subunit Beta 7) is a Protein Coding gene. Among its related pathways are RET signaling and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB10.

UniProtKB/Swiss-Prot for PSMB7 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the trypsin-like activity.

Gene Wiki entry for PSMB7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB7 Gene

Genomics for PSMB7 Gene

Regulatory Elements for PSMB7 Gene

Enhancers for PSMB7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F124385 2.4 FANTOM5 Ensembl ENCODE 11.5 +24.6 24550 10.8 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 FOS NFYC NEK6 PSMB7 NR5A1 ENSG00000231149 LHX2 ENSG00000231227 LOC100505588 DENND1A GC09P124378
GH09F124414 0.6 ENCODE 10.8 +0.4 407 2.1 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 NEK6 PSMB7 GOLGA1 GC09P124378
GH09F124352 0.2 ENCODE 6.8 +61.6 61593 3.5 HDGF PKNOX1 ZNF175 BACH1 FOSL1 CTBP1 ZNF766 POLR2A FOS ZNF584 NEK6 PSMB7 LOC100129034 PIR47713
GH09F124340 1.2 Ensembl ENCODE 5.3 +72.2 72224 4.8 BCOR KLF1 TAL1 ZMYM3 CEBPG ZIC2 HIC1 ZFHX2 GATA3 GLIS2 NEK6 PSMB7 PIR33879 LOC105376269
GH09F124410 1.2 Ensembl ENCODE 5.1 +3.7 3696 2.7 CTCF JUN CEBPB JUND ATF3 ZNF512 FOS CUX1 MAFK NFE2L2 NR5A1 ENSG00000231149 NEK6 PSMB7 GC09P124378
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PSMB7 on UCSC Golden Path with GeneCards custom track

Promoters for PSMB7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001314064 273 1600 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for PSMB7 Gene

Chromosome:
9
Start:
124,353,465 bp from pter
End:
124,415,473 bp from pter
Size:
62,009 bases
Orientation:
Minus strand

Genomic View for PSMB7 Gene

Genes around PSMB7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB7 Gene

Proteins for PSMB7 Gene

  • Protein details for PSMB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99436-PSB7_HUMAN
    Recommended name:
    Proteasome subunit beta type-7
    Protein Accession:
    Q99436
    Secondary Accessions:
    • B4E0P1
    • Q5TBG6
    • Q96AG8
    • Q9BWA7

    Protein attributes for PSMB7 Gene

    Size:
    277 amino acids
    Molecular mass:
    29965 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. This subunit can be displaced by the equivalent immune-specific subunit PSMB10. Interacts with HIV-1 TAT protein.

    Three dimensional structures from OCA and Proteopedia for PSMB7 Gene

    Alternative splice isoforms for PSMB7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMB7 Gene

Selected DME Specific Peptides for PSMB7 Gene

Q99436:
  • IYPHGSTD
  • GSGSLAA
  • NDLGSGSN
  • VPNKKGTR
  • LGADTRAT
  • GAGTAADT
  • IYCCGAG
  • PVGGFSFDNCRRNA

Post-translational modifications for PSMB7 Gene

  • Ubiquitination at Lys 31, Lys 127, Lys 225, and Lys 249
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PSMB7 Gene

Gene Families for PSMB7 Gene

Graphical View of Domain Structure for InterPro Entry

Q99436

UniProtKB/Swiss-Prot:

PSB7_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB7: view

Function for PSMB7 Gene

Molecular function for PSMB7 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta type subunit Z,30kDa,homologous of mouse Psmb7,removed from the complex by MECL1/PSMD7 after IFNG stimulation
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the trypsin-like activity.

Enzyme Numbers (IUBMB) for PSMB7 Gene

Gene Ontology (GO) - Molecular Function for PSMB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 14733938
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMB7: view
genes like me logo Genes that share phenotypes with PSMB7: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMB7 Gene

Localization for PSMB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB7 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMB7 Gene COMPARTMENTS Subcellular localization image for PSMB7 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for PSMB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA,IDA 17323924
GO:0005634 nucleus IEA,IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMB7: view

Pathways & Interactions for PSMB7 Gene

SuperPathways for PSMB7 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
.78
.32
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMB7: view

Gene Ontology (GO) - Biological Process for PSMB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PSMB7: view

No data available for SIGNOR curated interactions for PSMB7 Gene

Drugs & Compounds for PSMB7 Gene

(3) Drugs for PSMB7 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 794
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMB7: view

Transcripts for PSMB7 Gene

Unigene Clusters for PSMB7 Gene

Proteasome (prosome, macropain) subunit, beta type, 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: -

Relevant External Links for PSMB7 Gene

GeneLoc Exon Structure for
PSMB7
ECgene alternative splicing isoforms for
PSMB7

Expression for PSMB7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMB7 Gene

Protein differential expression in normal tissues from HIPED for PSMB7 Gene

This gene is overexpressed in Amniocyte (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMB7 Gene



Protein tissue co-expression partners for PSMB7 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSMB7 Gene:

PSMB7

SOURCE GeneReport for Unigene cluster for PSMB7 Gene:

Hs.213470

mRNA Expression by UniProt/SwissProt for PSMB7 Gene:

Q99436-PSB7_HUMAN
Tissue specificity: Expressed at a low level in colonic mucosa. Up-regulated in colorectal cancer tissues.
genes like me logo Genes that share expression patterns with PSMB7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PSMB7 Gene

Orthologs for PSMB7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMB7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMB7 34 35
  • 99.52 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMB7 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSMB7 34 35
  • 92.06 (n)
dog
(Canis familiaris)
Mammalia PSMB7 34 35
  • 91.34 (n)
-- 35
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Psmb7 34
  • 90.25 (n)
mouse
(Mus musculus)
Mammalia Psmb7 34 16 35
  • 90.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PSMB7 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMB7 34 35
  • 76.77 (n)
lizard
(Anolis carolinensis)
Reptilia PSMB7 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb7 34
  • 72.68 (n)
Str.421 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.3306 34
zebrafish
(Danio rerio)
Actinopterygii psmb7 34 35
  • 71.36 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11154 34
fruit fly
(Drosophila melanogaster)
Insecta Prosbgr2 36
  • 64 (a)
Prosbeta2 34 35
  • 62.79 (n)
CG18341 36
  • 57 (a)
Prosbeta2R1 35
  • 48 (a)
ManyToMany
Prosbeta2R2 35
  • 31 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011423 34
  • 63.98 (n)
worm
(Caenorhabditis elegans)
Secernentea pbs-2 35
  • 41 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A02233g 34
  • 56.6 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUP1 34 35 37
  • 56.12 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PBB1 34
  • 58.17 (n)
soybean
(Glycine max)
eudicotyledons Gma.5581 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6659 34
rice
(Oryza sativa)
Liliopsida Os05g0187000 34
  • 60.55 (n)
Os.12182 34
barley
(Hordeum vulgare)
Liliopsida Hv.2613 34
wheat
(Triticum aestivum)
Liliopsida Ta.14021 34
corn
(Zea mays)
Liliopsida Zm.6982 34
bread mold
(Neurospora crassa)
Ascomycetes NCU08605 34
  • 59.97 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pup1 34
  • 59.26 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7320 34
Species where no ortholog for PSMB7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMB7 Gene

ENSEMBL:
Gene Tree for PSMB7 (if available)
TreeFam:
Gene Tree for PSMB7 (if available)

Paralogs for PSMB7 Gene

Paralogs for PSMB7 Gene

(3) SIMAP similar genes for PSMB7 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PSMB7 Gene

genes like me logo Genes that share paralogs with PSMB7: view

Variants for PSMB7 Gene

Sequence variations from dbSNP and Humsavar for PSMB7 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1007185 -- 124,374,365(-) tctaa(C/G)tgtgt intron-variant
rs10119911 -- 124,364,893(+) AACAT(C/T)TGGAT intron-variant
rs10123514 -- 124,380,599(+) AGATA(C/T)AAACT intron-variant
rs1041012 -- 124,362,750(-) catgc(A/G)ttacc intron-variant
rs1041013 -- 124,362,369(-) AAGGC(A/G)AGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMB7 Gene

Variant ID Type Subtype PubMed ID
dgv12866n54 CNV loss 21841781
esv3621721 CNV gain 21293372
esv3621722 CNV gain 21293372
nsv471322 CNV loss 18288195
nsv519767 CNV loss 19592680
nsv615290 CNV loss 21841781

Variation tolerance for PSMB7 Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.39; 94.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMB7 Gene

Human Gene Mutation Database (HGMD)
PSMB7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMB7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMB7 Gene

Disorders for PSMB7 Gene

Relevant External Links for PSMB7

Genetic Association Database (GAD)
PSMB7
Human Genome Epidemiology (HuGE) Navigator
PSMB7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMB7

No disorders were found for PSMB7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMB7 Gene

Publications for PSMB7 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Proteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer. (PMID: 18549262) Rho J.H. … Roehrl M.H. (J. Proteome Res. 2008) 3 4 64
  3. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X. … Huang L. (Biochemistry 2007) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for PSMB7 Gene

Sources for PSMB7 Gene

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