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Aliases for PSMB7 Gene

Aliases for PSMB7 Gene

  • Proteasome Subunit Beta 7 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 7 2 3
  • Multicatalytic Endopeptidase Complex Chain Z 3 4
  • Proteasome Subunit Z 3 4
  • Macropain Chain Z 3 4
  • EC 3.4.25.1 4 58
  • Z 3 4
  • Proteasome Catalytic Subunit 2 3
  • Proteasome Subunit Beta Type-7 3
  • Protein Serine Kinase C17 3
  • Proteasome Subunit Alpha 3

External Ids for PSMB7 Gene

Previous GeneCards Identifiers for PSMB7 Gene

  • GC09M118230
  • GC09M118762
  • GC09M120569
  • GC09M122491
  • GC09M124195
  • GC09M126155
  • GC09M127115
  • GC09M096700

Summaries for PSMB7 Gene

Entrez Gene Summary for PSMB7 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMB7 Gene

PSMB7 (Proteasome Subunit Beta 7) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and RET signaling. GO annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB10.

UniProtKB/Swiss-Prot for PSMB7 Gene

  • Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.

Gene Wiki entry for PSMB7 Gene

Additional gene information for PSMB7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB7 Gene

Genomics for PSMB7 Gene

Regulatory Elements for PSMB7 Gene

Enhancers for PSMB7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H124385 2.3 Ensembl ENCODE 10.9 +28.8 28756 2 FOXA2 ATF1 MLX ARID4B FEZF1 DMAP1 YY1 FOS ATF7 MXD4 NEK6 PSMB7 ENSG00000231149 NR5A1 GC09P124378
GH09H124390 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +22.1 22145 5 HDGF PKNOX1 FOXA2 ARNT SIN3A GATA2 FOS RUNX3 TSHZ1 SMARCA4 NEK6 PSMB7 NR5A1 ENSG00000231149 ENSG00000231227 LOC100505588 LHX2 DENND1A GC09P124378
GH09H124414 1.4 ENCODE dbSUPER 10.8 +0.4 407 2 HNRNPUL1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 GAPVD1 GOLGA1 PRPS1P2 NEK6 PSMB7 GC09P124378
GH09H124410 1.2 Ensembl ENCODE dbSUPER 5.1 +3.7 3696 2 CTCF JUN CHD1 CEBPB CEBPG JUND ATF3 POLR2A FOS CUX1 NR5A1 ENSG00000231149 NEK6 PSMB7 GC09P124378
GH09H124340 1 Ensembl ENCODE 5.3 +72.2 72224 4 MAZ KLF1 ZNF398 ZIC2 ZBTB7A HIC1 ZFHX2 GLIS2 JUND POLR2A NEK6 PSMB7 PIR33879 LOC105376269
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSMB7 on UCSC Golden Path with GeneCards custom track

Promoters for PSMB7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000241285 173 1400 HNRNPUL1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for PSMB7 Gene

Chromosome:
9
Start:
124,353,465 bp from pter
End:
124,415,473 bp from pter
Size:
62,009 bases
Orientation:
Minus strand

Genomic View for PSMB7 Gene

Genes around PSMB7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB7 Gene

Proteins for PSMB7 Gene

  • Protein details for PSMB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99436-PSB7_HUMAN
    Recommended name:
    Proteasome subunit beta type-7
    Protein Accession:
    Q99436
    Secondary Accessions:
    • B4E0P1
    • Q5TBG6
    • Q96AG8
    • Q9BWA7

    Protein attributes for PSMB7 Gene

    Size:
    277 amino acids
    Molecular mass:
    29965 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Interacts with HIV-1 TAT protein (PubMed:14550573).

    Three dimensional structures from OCA and Proteopedia for PSMB7 Gene

    Alternative splice isoforms for PSMB7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMB7 Gene

Selected DME Specific Peptides for PSMB7 Gene

Q99436:
  • IYPHGSTD
  • GSGSLAA
  • NDLGSGSN
  • VPNKKGTR
  • LGADTRAT
  • GAGTAADT
  • IYCCGAG
  • PVGGFSFDNCRRNA

Post-translational modifications for PSMB7 Gene

  • Ubiquitination at isoforms=231, Lys127, isoforms=225, and Lys249
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSMB7 (PSMB7)

Domains & Families for PSMB7 Gene

Gene Families for PSMB7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q99436

UniProtKB/Swiss-Prot:

PSB7_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB7: view

Function for PSMB7 Gene

Molecular function for PSMB7 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta type subunit Z,30kDa,homologous of mouse Psmb7,removed from the complex by MECL1/PSMD7 after IFNG stimulation
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.

Enzyme Numbers (IUBMB) for PSMB7 Gene

Phenotypes From GWAS Catalog for PSMB7 Gene

Gene Ontology (GO) - Molecular Function for PSMB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 14733938
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMB7: view
genes like me logo Genes that share phenotypes with PSMB7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PSMB7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMB7 Gene

Localization for PSMB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB7 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMB7 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA,IEA 17323924
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IEA,IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PSMB7: view

Pathways & Interactions for PSMB7 Gene

SuperPathways for PSMB7 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMB7: view

Gene Ontology (GO) - Biological Process for PSMB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PSMB7: view

No data available for SIGNOR curated interactions for PSMB7 Gene

Drugs & Compounds for PSMB7 Gene

(3) Drugs for PSMB7 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 814
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMB7: view

Transcripts for PSMB7 Gene

Unigene Clusters for PSMB7 Gene

Proteasome (prosome, macropain) subunit, beta type, 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PSMB7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: -

Relevant External Links for PSMB7 Gene

GeneLoc Exon Structure for
PSMB7
ECgene alternative splicing isoforms for
PSMB7

Expression for PSMB7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMB7 Gene

Protein differential expression in normal tissues from HIPED for PSMB7 Gene

This gene is overexpressed in Amniocyte (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMB7 Gene



Protein tissue co-expression partners for PSMB7 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSMB7 Gene:

PSMB7

SOURCE GeneReport for Unigene cluster for PSMB7 Gene:

Hs.213470

mRNA Expression by UniProt/SwissProt for PSMB7 Gene:

Q99436-PSB7_HUMAN
Tissue specificity: Expressed at a low level in colonic mucosa. Up-regulated in colorectal cancer tissues.

Evidence on tissue expression from TISSUES for PSMB7 Gene

  • Liver(4.7)
  • Lung(4.7)
  • Nervous system(4.3)
  • Skin(3.1)
  • Intestine(2.6)
  • Muscle(2.4)
  • Pancreas(2.4)
  • Eye(2.2)
  • Kidney(2.2)
  • Adrenal gland(2)
  • Heart(2)
genes like me logo Genes that share expression patterns with PSMB7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMB7 Gene

Orthologs for PSMB7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMB7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMB7 33 34
  • 99.52 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMB7 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSMB7 33 34
  • 92.06 (n)
dog
(Canis familiaris)
Mammalia PSMB7 33 34
  • 91.34 (n)
-- 34
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Psmb7 33
  • 90.25 (n)
mouse
(Mus musculus)
Mammalia Psmb7 33 16 34
  • 90.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PSMB7 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMB7 33 34
  • 76.77 (n)
lizard
(Anolis carolinensis)
Reptilia PSMB7 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb7 33
  • 72.68 (n)
Str.421 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3306 33
zebrafish
(Danio rerio)
Actinopterygii psmb7 33 34
  • 71.36 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11154 33
fruit fly
(Drosophila melanogaster)
Insecta Prosbgr2 35
  • 64 (a)
Prosbeta2 33 34
  • 62.79 (n)
CG18341 35
  • 57 (a)
Prosbeta2R1 34
  • 48 (a)
ManyToMany
Prosbeta2R2 34
  • 31 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011423 33
  • 63.98 (n)
worm
(Caenorhabditis elegans)
Secernentea pbs-2 34
  • 41 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A02233g 33
  • 56.6 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUP1 33 34 36
  • 56.12 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PBB1 33
  • 58.17 (n)
soybean
(Glycine max)
eudicotyledons Gma.5581 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6659 33
rice
(Oryza sativa)
Liliopsida Os05g0187000 33
  • 60.55 (n)
Os.12182 33
barley
(Hordeum vulgare)
Liliopsida Hv.2613 33
wheat
(Triticum aestivum)
Liliopsida Ta.14021 33
corn
(Zea mays)
Liliopsida Zm.6982 33
bread mold
(Neurospora crassa)
Ascomycetes NCU08605 33
  • 59.97 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pup1 33
  • 59.26 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7320 33
Species where no ortholog for PSMB7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMB7 Gene

ENSEMBL:
Gene Tree for PSMB7 (if available)
TreeFam:
Gene Tree for PSMB7 (if available)

Paralogs for PSMB7 Gene

Paralogs for PSMB7 Gene

(3) SIMAP similar genes for PSMB7 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PSMB7 Gene

genes like me logo Genes that share paralogs with PSMB7: view

Variants for PSMB7 Gene

Sequence variations from dbSNP and Humsavar for PSMB7 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000063063 -- 124,362,316(+) CTGAG(A/G)AACAG intron-variant
rs1000070141 -- 124,387,762(+) TCTGA(A/C)TGTGT intron-variant
rs1000072534 -- 124,354,779(+) GCAGC(A/G)TGCAG intron-variant, nc-transcript-variant
rs1000318172 -- 124,378,876(+) TAACT(A/G)GAAAA intron-variant
rs1000326448 -- 124,380,274(+) ATGTA(C/T)CCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMB7 Gene

Variant ID Type Subtype PubMed ID
dgv12866n54 CNV loss 21841781
esv3621721 CNV gain 21293372
esv3621722 CNV gain 21293372
nsv471322 CNV loss 18288195
nsv519767 CNV loss 19592680
nsv615290 CNV loss 21841781

Variation tolerance for PSMB7 Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.39; 94.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMB7 Gene

Human Gene Mutation Database (HGMD)
PSMB7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMB7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMB7 Gene

Disorders for PSMB7 Gene

Relevant External Links for PSMB7

Genetic Association Database (GAD)
PSMB7
Human Genome Epidemiology (HuGE) Navigator
PSMB7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMB7

No disorders were found for PSMB7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMB7 Gene

Publications for PSMB7 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Proteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer. (PMID: 18549262) Rho JH … Roehrl MH (Journal of proteome research 2008) 3 4 60
  3. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for PSMB7 Gene

Sources for PSMB7 Gene

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