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Aliases for PSMB6 Gene

Aliases for PSMB6 Gene

  • Proteasome Subunit Beta 6 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 6 2 3
  • Multicatalytic Endopeptidase Complex Delta Chain 3 4
  • Proteasome Delta Chain 3 4
  • Macropain Delta Chain 3 4
  • Proteasome Subunit Y 3 4
  • EC 3.4.25.1 4 61
  • LMPY 3 4
  • Y 3 4
  • PSY Large Multifunctional Protease Y 3
  • Proteasome Catalytic Subunit 1 3
  • Proteasome Subunit Beta Type-6 3
  • Proteasome Subunit Delta 3
  • Delta 3

External Ids for PSMB6 Gene

Previous GeneCards Identifiers for PSMB6 Gene

  • GC17P005126
  • GC17P004650
  • GC17P004906
  • GC17P004646
  • GC17P004699
  • GC17P004587

Summaries for PSMB6 Gene

Entrez Gene Summary for PSMB6 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMB6 Gene

PSMB6 (Proteasome Subunit Beta 6) is a Protein Coding gene. Diseases associated with PSMB6 include Hiv-1. Among its related pathways are RET signaling and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is PSMB9.

UniProtKB/Swiss-Prot for PSMB6 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the peptidyl glutamyl-like activity. May catalyze basal processing of intracellular antigens.

Gene Wiki entry for PSMB6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB6 Gene

Genomics for PSMB6 Gene

Regulatory Elements for PSMB6 Gene

Enhancers for PSMB6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F004842 1.2 FANTOM5 Ensembl ENCODE 11.9 +48.4 48357 3.8 KLF1 PKNOX1 HLF EED ZNF341 PBX2 NFE2 PRDM10 ETV6 SPI1 CHRNE ENO3 ARRB2 ZMYND15 CXCL16 C17orf107 PLD2 PSMB6 RPS12P29 LOC101559451
GH17F004795 0.4 ENCODE 0.8 +0.1 99 1.7 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS PLD2 LOC105371506 ENSG00000262165 NUP88 C17orf107 PSMB6
GH17F004786 0.2 ENCODE 0.4 -7.4 -7405 5.3 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF207 ZNF143 VMO1 RNF167 GLTPD2 PSMB6
GH17F004801 0.7 FANTOM5 0.4 +5.2 5248 0.4 HDAC1 HDGF ATF1 NFRKB ZNF133 ZNF76 SIN3A GLI4 DMAP1 ZNF2 ENSG00000262165 LOC105371506 MINK1 ZNF232 KIF1C PSMB6
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PSMB6 on UCSC Golden Path with GeneCards custom track

Promoters for PSMB6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001804580 157 1400 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 DEK

Genomic Location for PSMB6 Gene

Chromosome:
17
Start:
4,796,144 bp from pter
End:
4,798,503 bp from pter
Size:
2,360 bases
Orientation:
Plus strand

Genomic View for PSMB6 Gene

Genes around PSMB6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB6 Gene

Proteins for PSMB6 Gene

  • Protein details for PSMB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28072-PSB6_HUMAN
    Recommended name:
    Proteasome subunit beta type-6
    Protein Accession:
    P28072
    Secondary Accessions:
    • Q96J55

    Protein attributes for PSMB6 Gene

    Size:
    239 amino acids
    Molecular mass:
    25358 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. This subunit can be displaced by the equivalent immune-specific subunit PSMB9. Interacts with HIV-1 TAT protein.

    Three dimensional structures from OCA and Proteopedia for PSMB6 Gene

neXtProt entry for PSMB6 Gene

Selected DME Specific Peptides for PSMB6 Gene

P28072:
  • CRSGSAAD
  • TGTTIMAV
  • YIANRVT
  • RDGSSGGV
  • ALAMERDGSSGG
  • GSGSSYIYGYVDA
  • GGSGSSY

Post-translational modifications for PSMB6 Gene

  • Ubiquitination at Lys 230
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB6 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSMB6 (PSMB6)
  • Cloud-Clone Corp. Antibodies for PSMB6
  • Santa Cruz Biotechnology (SCBT) Antibodies for PSMB6

Domains & Families for PSMB6 Gene

Gene Families for PSMB6 Gene

Suggested Antigen Peptide Sequences for PSMB6 Gene

Graphical View of Domain Structure for InterPro Entry

P28072

UniProtKB/Swiss-Prot:

PSB6_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB6: view

Function for PSMB6 Gene

Molecular function for PSMB6 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta type 1,subunit delta/Y ,25 kDa
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the peptidyl glutamyl-like activity. May catalyze basal processing of intracellular antigens.
UniProtKB/Swiss-Prot Induction:
Down-regulated by IFNG/IFN-gamma (at protein level). Up-regulated in anaplastic thyroid cancer cell lines.

Enzyme Numbers (IUBMB) for PSMB6 Gene

Gene Ontology (GO) - Molecular Function for PSMB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA,NAS 8066462
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with PSMB6: view
genes like me logo Genes that share phenotypes with PSMB6: view

Animal Model Products

miRNA for PSMB6 Gene

miRTarBase miRNAs that target PSMB6

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMB6 Gene

Localization for PSMB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB6 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMB6 Gene COMPARTMENTS Subcellular localization image for PSMB6 gene
Compartment Confidence
cytosol 5
extracellular 5
golgi apparatus 5
nucleus 5

Gene Ontology (GO) - Cellular Components for PSMB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA,IDA 17323924
GO:0005634 nucleus IEA,IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with PSMB6: view

Pathways & Interactions for PSMB6 Gene

SuperPathways for PSMB6 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
.78
.32
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMB6: view

Gene Ontology (GO) - Biological Process for PSMB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PSMB6: view

No data available for SIGNOR curated interactions for PSMB6 Gene

Drugs & Compounds for PSMB6 Gene

(3) Drugs for PSMB6 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 794
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMB6: view

Transcripts for PSMB6 Gene

Unigene Clusters for PSMB6 Gene

Proteasome (prosome, macropain) subunit, beta type, 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for PSMB6 Gene

GeneLoc Exon Structure for
PSMB6
ECgene alternative splicing isoforms for
PSMB6

Expression for PSMB6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMB6 Gene

Protein differential expression in normal tissues from HIPED for PSMB6 Gene

This gene is overexpressed in Liver, secretome (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMB6 Gene



Protein tissue co-expression partners for PSMB6 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSMB6 Gene:

PSMB6

SOURCE GeneReport for Unigene cluster for PSMB6 Gene:

Hs.77060
genes like me logo Genes that share expression patterns with PSMB6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMB6 Gene

Orthologs for PSMB6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMB6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMB6 34 35
  • 99.3 (n)
dog
(Canis familiaris)
Mammalia PSMB6 34 35
  • 89.92 (n)
cow
(Bos Taurus)
Mammalia PSMB6 34 35
  • 89.78 (n)
mouse
(Mus musculus)
Mammalia Psmb6 34 16 35
  • 89.64 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 82 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia PSMB6 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb6 34
  • 75.52 (n)
MGC75674 34
zebrafish
(Danio rerio)
Actinopterygii psmb6 34 35
  • 75.04 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8481 34
fruit fly
(Drosophila melanogaster)
Insecta l(2)05070 36
  • 57 (a)
Prosbeta1 35
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pbs-1 35
  • 40 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL172C 34
  • 60.1 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F12936g 34
  • 57.19 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE3 34 35 37
  • 54.06 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PBA1 34
  • 54.15 (n)
rice
(Oryza sativa)
Liliopsida Os02g0770000 34
  • 55.39 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5051 35
  • 63 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU09290 34
  • 58.38 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pre3 34
  • 56.6 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5142 34
Species where no ortholog for PSMB6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMB6 Gene

ENSEMBL:
Gene Tree for PSMB6 (if available)
TreeFam:
Gene Tree for PSMB6 (if available)

Paralogs for PSMB6 Gene

Paralogs for PSMB6 Gene

(6) SIMAP similar genes for PSMB6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PSMB6: view

Variants for PSMB6 Gene

Sequence variations from dbSNP and Humsavar for PSMB6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1050296 -- 4,798,434(+) GGATT(C/T)TAGTA utr-variant-3-prime
rs111468504 -- 4,797,958(+) TGTAC(A/G/T)TGTGT intron-variant
rs111471700 -- 4,794,702(+) AGGCG(C/G)GTGGA upstream-variant-2KB
rs111502268 -- 4,794,849(+) TGGCG(A/T)GAACC upstream-variant-2KB
rs111908909 -- 4,796,589(+) ATTCT(A/G)CGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMB6 Gene

Variant ID Type Subtype PubMed ID
nsv574273 CNV gain 21841781
nsv833346 CNV loss 17160897
nsv833347 CNV loss 17160897

Variation tolerance for PSMB6 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.68; 57.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMB6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMB6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMB6 Gene

Disorders for PSMB6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSMB6 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search PSMB6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSMB6

Genetic Association Database (GAD)
PSMB6
Human Genome Epidemiology (HuGE) Navigator
PSMB6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMB6
genes like me logo Genes that share disorders with PSMB6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMB6 Gene

Publications for PSMB6 Gene

  1. cDNA cloning and interferon gamma down-regulation of proteasomal subunits X and Y. (PMID: 8066462) Akiyama K.-Y. … Ichihara A. (Science 1994) 2 3 4 64
  2. The primary structures of four subunits of the human, high-molecular- weight proteinase, macropain (proteasome), are distinct but homologous. (PMID: 1888762) DeMartino G.N. … Slaughter C.A. (Biochim. Biophys. Acta 1991) 2 3 4 64
  3. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X. … Huang L. (Biochemistry 2007) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. (PMID: 14550573) Apcher G.S. … Krueger E. (FEBS Lett. 2003) 3 4 64

Products for PSMB6 Gene

Sources for PSMB6 Gene

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