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PSMB5 Gene

protein-coding   GIFtS: 68
GCID: GC14M023485

Proteasome (Prosome, Macropain) Subunit, Beta Type, 5

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proteasome (Prosome, Macropain) Subunit, Beta Type, 51 2     MB12 3
LMPX2 3 5     X2 3
Macropain Epsilon Chain2 3     EC 3.4.25.13 8
Multicatalytic Endopeptidase Complex Epsilon Chain2 3     Proteasome Beta 5 Subunit2
Proteasome Chain 62 3     Proteasome Catalytic Subunit 32
Proteasome Epsilon Chain2 3     Proteasome Subunit Beta Type-52
Proteasome Subunit MB12 3     Proteasome Subunit, Beta Type, 52
Proteasome Subunit X2 3     PSX Large Multifunctional Protease X2

External Ids:    HGNC: 95421   Entrez Gene: 56932   Ensembl: ENSG000001008047   OMIM: 6003065   UniProtKB: P280743   

Export aliases for PSMB5 gene to outside databases

Previous GC identifers: GC14M020867 GC14M017282 GC14M021475 GC14M021485 GC14M022564 GC14M023495 GC14M003612


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PSMB5 Gene:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The
core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and
2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high
concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential
function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene
encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit
in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic
subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Jan 2009)

GeneCards Summary for PSMB5 Gene:
PSMB5 (proteasome (prosome, macropain) subunit, beta type, 5) is a protein-coding gene. GO annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB8.

UniProtKB/Swiss-Prot: PSB5_HUMAN, P28074
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity
of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib. May catalyze basal
processing of intracellular antigens. Plays a role in the protection against oxidative damage through the
Nrf2-ARE pathway (By similarity)

Gene Wiki entry for PSMB5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PSMB5 gene promoter:
         RFX1   Pax-5   Nkx2-5   Zic3   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSMB5 promoter sequence
   Search Chromatin IP Primers for PSMB5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSMB5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

PSMB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMB5 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M023485:  view genomic region     (about GC identifiers)

Start:
23,485,752 bp from pter      End:
23,504,439 bp from pter
Size:
18,688 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PSB5_HUMAN, P28074 (See protein sequence)
Recommended Name: Proteasome subunit beta type-5 precursor  
Size: 263 amino acids; 28480 Da
Subunit: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome
core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure.
The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven
beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. This subunit can be
displaced by the equivalent immune-specific subunit PSMB8. Directly interacts with POMP. Interacts with HIV-1 TAT
protein. Interacts with ABCB1 and TAP1
Sequence caution: Sequence=AAP35423.1; Type=Erroneous initiation; Sequence=BAA06097.1; Type=Erroneous initiation;
Sequence=CAD97956.1; Type=Erroneous initiation;
Secondary accessions: B2R4N9 B4DUM9 D3DS43 E9PAV2 Q16242 Q6PEW2 Q7Z3B5 Q86T01 Q9TNN9
Alternative splicing: 3 isoforms:  P28074-1   P28074-2   P28074-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PSMB5: NX_P28074

Explore proteomics data for PSMB5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys91, Lys92
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PSMB5 (P28074) (see all 10)
     AGGAADC  RDAYSGG  DSRATAG  VAADSRA 


    See PSMB5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001124197.1  NP_001138404.1  NP_002788.1  

    ENSEMBL proteins: 
     ENSP00000451816   ENSP00000355325   ENSP00000452424   ENSP00000451286   ENSP00000395206  
     ENSP00000334973  
    Reactome Protein details: P28074

    PSMB5 Human Recombinant Protein Products:

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    Novus Biologicals PSMB5 Proteins
    Novus Biologicals PSMB5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PSMB5
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PSMB5 

     
    antibodies-online proteins for PSMB5 (18 products) 

     
    antibodies-online peptides for PSMB5

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    Abcam antibodies for PSMB5 (P28074, P18421)
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    antibodies-online antibodies for PSMB5 (33 products) 

    PSMB5 Assay Products:

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    Search eBioscience for ELISAs for PSMB5 
    antibodies-online kits for PSMB5 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PSM: Proteasome (prosome, macropain) subunits

    4 InterPro protein domains:
     IPR001353 Proteasome_sua/b
     IPR016050 Proteasome_bsu_CS
     IPR000243 Pept_T1A_subB
     IPR023333 Proteasome_suB-type

    Graphical View of Domain Structure for InterPro Entry P28074

    ProtoNet protein and cluster: P28074

    1 Blocks protein domain: IPB000243 Proteasome B-type subunit

    UniProtKB/Swiss-Prot: PSB5_HUMAN, P28074
    Similarity: Belongs to the peptidase T1B family


    Find genes that share domains with PSMB5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PSB5_HUMAN, P28074
    Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
    peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
    proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity
    of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib. May catalyze basal
    processing of intracellular antigens. Plays a role in the protection against oxidative damage through the
    Nrf2-ARE pathway (By similarity)
    Catalytic activity: Cleavage of peptide bonds with very broad specificity
    Induction: Down-regulated by IFNG/IFN-gamma (at protein level). Induced in breast cancer tissue. Up-regulated by
    sulforaphane in breast cancer cells

         Genatlas biochemistry entry for PSMB5:
    multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta,subunit MB-1/X,22.9kDa

         Enzyme Number (IUBMB): EC 3.4.25.11 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004298threonine-type endopeptidase activity IEA--
    GO:0005515protein binding IPI14733938
    GO:0008233peptidase activity ----
         
    Find genes that share ontologies with PSMB5           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for PSMB5:
     Decreased viability with pacli  G2 arrest  Increased G2M DNA content  Synthetic lethal with Ras 

         1 MGI phenotypic allele for Psmb5 (no phenotypes)

    Find genes that share phenotypes with PSMB5           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PSMB5

    miRNA
    Products:
        
    miRTarBase miRNAs that target PSMB5:
    hsa-mir-30e-5p (MIRT044149), hsa-mir-423-3p (MIRT042548), hsa-mir-142-3p (MIRT021543), hsa-mir-221-3p (MIRT046973), hsa-mir-18a-5p (MIRT031323)

    Block miRNA regulation of human, mouse, rat PSMB5 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate PSMB5:
    hsa-miR-33a*
    SwitchGear 3'UTR luciferase reporter plasmidPSMB5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PSMB5
    Predesigned siRNA for gene silencing in human, mouse, rat PSMB5

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): PSMB5 (NM_001130725)
    Sino Biological Human cDNA Clone for PSMB5
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMB5

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMB5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PSB5_HUMAN, P28074: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex TAS8811196
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with PSMB5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PSMB5 About   (see all 28)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    CDK-mediated phosphorylation and removal of Cdc60.94
    Destabilization of mRNA by AUF1 (hnRNP D0)0.88
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    G1/S DNA Damage Checkpoints0.87
    Ubiquitin-dependent degradation of Cyclin D10.94
    CDT1 association with the CDC6-ORC-origin complex0.87
    Ubiquitin-dependent degradation of Cyclin D0.94
    SCF(Skp2)-mediated degradation of p27/p210.86
    2Chks in Checkpoint Regulation
    Chks in Checkpoint Regulation0.59
    SREBP Proteolysis0.43
    G2-M Phase Transition0.59
    DNA Repair Mechanisms0.32
    Estrogen-mediated S-Phase Entry0.55
    3Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84


    Find genes that share SuperPaths with PSMB5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PSMB5 (see all 17)
        CDK5 Pathway
    Estrogen-mediated S-Phase Entry
    G2-M Phase Transition
    DNA Repair Mechanisms
    GSK3 Signaling

    1 Cell Signaling Technology (CST) Pathway for PSMB5
        Protein Stability

    4 GeneGo (Thomson Reuters) Pathways for PSMB5
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Antigen presentation by MHC class I
    Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of wt-CFTR

    2 BioSystems Pathways for PSMB5
        Proteasome Degradation
    TNF-alpha/NF-kB Signaling Pathway


    Selected Reactome Pathways for PSMB5 (see all 24)
        SCF(Skp2)-mediated degradation of p27/p21
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
    SCF-beta-TrCP mediated degradation of Emi1
    Ubiquitin-dependent degradation of Cyclin D1
    Orc1 removal from chromatin


    1 Kegg Pathway  (Kegg details for PSMB5):
        Proteasome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PSMB5
    Interactions:

        Search GeneGlobe Interaction Network for PSMB5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PSMB5 (P280741, 2, 3 ENSP000003553254) via UniProtKB, MINT, STRING, and/or I2D (see all 255)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POMPQ9Y2441, 2, 3, ENSP000003702224EBI-357828,EBI-696895 MINT-6176307 MINT-6176482 MINT-6176080 MINT-6176266 I2D: score=3 STRING: ENSP00000370222
    PSMB7Q994361, 2, 3, ENSP000002594574EBI-357828,EBI-603319 MINT-4050722 MINT-6176080 MINT-6176256 I2D: score=9 STRING: ENSP00000259457
    PSMB4P280702, 3, ENSP000002905414MINT-4050722 MINT-6176080 MINT-6176246 I2D: score=6 STRING: ENSP00000290541
    PSMB2P497212, 3, ENSP000003623344MINT-4050722 MINT-6176080 I2D: score=9 STRING: ENSP00000362334
    PSMA7O148182, 3, ENSP000003599104MINT-4050722 MINT-6176080 I2D: score=6 STRING: ENSP00000359910
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--

    Find genes that share ontologies with PSMB5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for PSMB5 (see all 16)     About this table
    CompoundAction CAS #
    Aclacinomycin ASpecific inhibitor of the 20S proteasome chymotrypsin-like activity[57576-44-0]
    AM 114Boronic-chalcone derived proteasome inhibitor with anticancer activity[856849-35-9]
    Bortezomib (PS-341, LDP-3411)Cell-permeable proteasome inhibitor[179324-69-7]
    Carfilzomib (PR-171)Proteasome inhibitor, analog of epoxomicin[868540-17-4]
    CEP-18770Orally active inhibitor of the chymotrypsin-like activity of proteasome[847499-27-8]
    DihydroeponemycinProteasome inhibitor and antitumor reagent[126463-64-7]
    EpoxomicinIrreversible proteasome inhibitor[134381-21-8]
    GliotoxinNon-competitively inhibits chymotrypsin-like activity of 20S proteasome[67-99-2]
    MG-115Reversible proteasome inhibitor--
    MG-132Cell permeable, reversible proteasome inhibitor[133407-82-6]

    Browse Tocris compounds for PSMB5 (PSB5)

    4 DrugBank Compounds for PSMB5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Bortezomib-- 179324-69-7targetantagonist20954323 16081156
    (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE-- --target--10592235
    Carfilzomib -- 868540-17-4targetinhibitor23393020
    N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PSMB5 gene (3 alternative transcripts): 
    NM_001130725.1  NM_001144932.2  NM_002797.4  

    Unigene Cluster for PSMB5:

    Proteasome (prosome, macropain) subunit, beta type, 5
    Hs.422990  [show with all ESTs]
    Unigene Representative Sequence: BF972112
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555895 ENST00000361611(uc001wij.3 uc001wii.3) ENST00000493471
    ENST00000460922 ENST00000425762(uc010tni.2) ENST00000334454
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate PSMB5:
    hsa-miR-33a*
    SwitchGear 3'UTR luciferase reporter plasmidPSMB5 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PSMB5
    Predesigned siRNA for gene silencing in human, mouse, rat PSMB5
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      QuantiTect SYBR Green Assays in human, mouse, rat PSMB5
      QuantiFast Probe-based Assays in human, mouse, rat PSMB5

    Additional mRNA sequence: 

    AK225888.1 AK300714.1 AK311895.1 BC057840.1 BC107720.1 BT006777.1 BX248299.1 BX538001.1 
    S74378.1 

    13 DOTS entries:

    DT.100060248  DT.92469202  DT.102828383  DT.86840348  DT.120731008  DT.100662743  DT.95356808  DT.100662744 
    DT.92469201  DT.95356678  DT.100051264  DT.92469192  DT.95241827 

    Selected AceView cDNA sequences (see all 702):

    BQ183951 BU859896 AW304952 BM669240 CA438910 AW780351 CD367950 BU163729 
    BQ653604 BU949257 D11621 AA838680 BU664177 AU106987 BU161851 BM465642 
    BM555401 CB134537 NM_002797 CA308545 BM505712 BQ018449 BM986962 BM762318 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PSMB5    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b
    SP1:                    -                 -                     
    SP2:                    -                 -     -               
    SP3:                    -                                       
    SP4:                                                            


    ECgene alternative splicing isoforms for PSMB5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PSMB5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAGTATAG
    PSMB5 Expression
    About this image


    PSMB5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
     
     Thyroid (Endocrine System)
    PSMB5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PSMB5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.422990
        Custom PCR Arrays for PSMB5
    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PSMB5 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Psmb51 , 5 proteasome (prosome, macropain) subunit, beta type more1, 5 88.67(n)1
    94.59(a)1
      14 (27.86 cM)5
    191731  NM_011186.11  NP_035316.11 
     546141205 
    lizard
    (Anolis carolinensis)
    Reptilia PSMB56
    proteasome (prosome, macropain) subunit, beta type...
    76(a)
    1 ↔ 1
    GL343879.1(117635-124054)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF548072.12   -- 77.52(n)    CF548072.1 
    zebrafish
    (Danio rerio)
    Actinopterygii psmb52 proteasome (prosome, macropain) subunit, beta type, more 76.14(n)   30387  AF155578.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pros&bgr;53
    Prosbeta51
    proteasome endopeptidase3
    Proteasome beta5 subunit1
    63(a)
    (best of 2)3
    63.86(n)1
    60.62(a)1
      47C13
    452691  NM_165801.11  NP_724974.11 
    worm
    (Caenorhabditis elegans)
    Secernentea pbs-51 pbs-5 52.4(n)
    49.25(a)
      173334  NM_061157.4  NP_493558.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRE2(YPR103W)4 Beta 5 subunit of the 20S proteasome, responsible for more   --   16(732349-733212) 856218  NP_015428.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G263401 AT3G26340 59.32(n)
    61.22(a)
      822238  NM_113541.3  NP_189265.1 
    rice
    (Oryza sativa)
    Liliopsida AK071652.12   -- 69.78(n)    AK071652.1 


    ENSEMBL Gene Tree for PSMB5 (if available)
    TreeFam Gene Tree for PSMB5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PSMB5 gene
    PSMB82  PSMB112  
    4 SIMAP similar genes for PSMB5 using alignment to 4 protein entries:     PSB5_HUMAN (see all proteins):
    PSMB8    PSMB11    PSMB9    PSMB6

    Find genes that share paralogs with PSMB5           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for PSMB5
    PGOHUM00000249121 PGOHUM00000233456


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PSMB5 (see all 204)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs600482141,2
    C,F--3623632(+) CTGTCG/ACCCAG 3 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1426127331,2
    --3623634(+) GTCGCC/TCAGGC 3 -- us2k10--------
    rs1842266511,2
    --3623654(+) GTGGCG/TCAATA 1 -- us2k10--------
    rs1893896421,2
    --3623684(+) ACCTCC/GTGGAT 1 -- us2k10--------
    rs1809765611,2
    --3623721(+) CCAAGG/TAGCTG 1 -- us2k10--------
    rs596576241,2
    C,F--23494844(-) ACAAAG/TAGATG 3 -- ds50011Minor allele frequency- T:0.00--526
    rs1864011051,2
    --23494941(+) ACTAGA/GCAATG 3 -- ds50010--------
    rs570798841,2
    F--23494959(-) GAAACAGT/-GGTGT 6 -- ds5001 cds11Minor allele frequency- -:0.01--526
    rs9417171,2
    C,F,A,H--23494987(+) TCCCTC/TCCACT 3 -- ds500126Minor allele frequency- T:0.45NS EA NA WA CSA 2880
    rs9417181,2
    C,F,A,H--23495048(+) AAAGAT/CGCAAC 3 -- ds500130Minor allele frequency- C:0.42NA EA NS WA CSA 3241

    HapMap Linkage Disequilibrium report for PSMB5 (23485752 - 23504439 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PSMB5: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PSMB5
    DNA2.0 Custom Variant and Variant Library Synthesis for PSMB5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600306    OMIM disorders: --


    Find genes that share disorders with PSMB5           About GenesLikeMe


    Export disorders for PSMB5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PSMB5 gene, integrated from 10 sources (see all 119):
    (articles sorted by number of sources associating them with PSMB5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and interferon gamma down-regulation of proteasomal subunits X and Y. (PubMed id 8066462)1, 2, 3 Akiyama K.-Y.... Ichihara A. (Science 1994)
    2. Different mutants of PSMB5 confer varying bortezomib resistance in T lymphoblastic lymphoma/leukemia cells derived from the Jurkat cell line. (PubMed id 19426847)1, 2 Lue S.... Wang J. (Exp. Hematol. 2009)
    3. Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein. (PubMed id 18565852)1, 2 Oerlemans R.... Jansen G. (Blood 2008)
    4. Point mutation of the proteasome beta5 subunit gene is an important mechanism of bortezomib resistance in bortezomib-selected variants of Jurkat T cell lymphoblastic lymphoma/leukemia line. (PubMed id 18502982)1, 2 Lue S.... Wang J. (J. Pharmacol. Exp. Ther. 2008)
    5. Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome. (PubMed id 15488952)1, 2 Begley G.S.... Higgins C.F. (Mol. Immunol. 2005)
    6. IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response. (PubMed id 15944226)1, 2 Heink S.... Krueger E. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. (PubMed id 14550573)1, 2 Apcher G.S.... Krueger E. (FEBS Lett. 2003)
    9. Divergent intron arrangement in the MB1/LMP7 proteasome gene pair. (PubMed id 8753855)1, 2 Abdulla S.... Trowsdale J. (Immunogenetics 1996)
    10. Structure and functions of the 20S and 26S proteasomes. (PubMed id 8811196)1, 3 Coux O....Goldberg A.L. (Annu. Rev. Biochem. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5693 HGNC: 9542 AceView: PSMB5 Ensembl:ENSG00000100804 euGenes: HUgn5693
    ECgene: PSMB5 Kegg: 5693 H-InvDB: PSMB5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PSMB5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PSMB5 gene:
    Search GeneIP for patents involving PSMB5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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