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Aliases for PSMB5 Gene

Aliases for PSMB5 Gene

  • Proteasome Subunit Beta 5 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 5 2 3
  • Multicatalytic Endopeptidase Complex Epsilon Chain 3 4
  • Proteasome Epsilon Chain 3 4
  • Macropain Epsilon Chain 3 4
  • Proteasome Subunit MB1 3 4
  • Proteasome Subunit X 3 4
  • Proteasome Chain 6 3 4
  • EC 3.4.25.1 4 61
  • LMPX 3 4
  • MB1 3 4
  • X 3 4
  • PSX Large Multifunctional Protease X 3
  • Proteasome Subunit, Beta Type, 5 3
  • Testicular Tissue Protein Li 153 3
  • Proteasome Catalytic Subunit 3 3
  • Proteasome Subunit Beta Type-5 3
  • Proteasome Beta 5 Subunit 3

External Ids for PSMB5 Gene

Previous GeneCards Identifiers for PSMB5 Gene

  • GC14M020867
  • GC14M017282
  • GC14M021475
  • GC14M021485
  • GC14M022564
  • GC14M023495
  • GC14M003612
  • GC14M023485

Summaries for PSMB5 Gene

Entrez Gene Summary for PSMB5 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

GeneCards Summary for PSMB5 Gene

PSMB5 (Proteasome Subunit Beta 5) is a Protein Coding gene. Among its related pathways are RET signaling and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include peptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is PSMB8.

UniProtKB/Swiss-Prot for PSMB5 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib. May catalyze basal processing of intracellular antigens. Plays a role in the protection against oxidative damage through the Nrf2-ARE pathway (By similarity).

Gene Wiki entry for PSMB5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB5 Gene

Genomics for PSMB5 Gene

Regulatory Elements for PSMB5 Gene

Enhancers for PSMB5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F022976 1.4 FANTOM5 ENCODE 15.1 +55.3 55325 7.6 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 PRMT5 HAUS4 LOC102724814 PABPN1 MMP14 LOC105370399 RN7SKP205 LOC105370409 TRAV37 LINC00596
GH14F023060 0.2 ENCODE 12.2 -27.5 -27541 4.3 PKNOX1 KLF17 SIN3A PLRG1 ZBTB40 DNMT3B ZNF2 RFX5 GLIS2 ZNF366 EFS PSMB11 PSMB5 ACIN1 C14orf93 C14orf119 AJUBA HAUS4 MIR4707 RNF212B
GH14F023067 0.9 Ensembl ENCODE 12.2 -35.2 -35233 5.9 HDGF PKNOX1 ARNT MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YBX1 PSMB11 PSMB5 C14orf119 ACIN1 C14orf93 CEBPE AJUBA HAUS4 MIR4707 RNF212B
GH14F022994 1 Ensembl ENCODE 12 +40.4 40363 1.1 ELF3 ARID4B ZNF48 RAD21 ZNF143 EGR2 HMG20B ZNF654 REST PPARG PRMT5 CDH24 PSMB5 PSMB11 ACIN1 GC14P023896 ENSG00000280129
GH14F022996 0.7 FANTOM5 11.9 +38.2 38222 0.2 PKNOX1 ZNF155 ZNF366 SCRT2 ZNF548 ZNF391 EGR2 OVOL3 ZNF488 TSHZ1 CDH24 ACIN1 PSMB5 PSMB11 PRMT5 C14orf119 CEBPE ENSG00000280129 GC14P023896
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PSMB5 on UCSC Golden Path with GeneCards custom track

Promoters for PSMB5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001455969 530 1801 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1

Genomic Location for PSMB5 Gene

Chromosome:
14
Start:
23,016,543 bp from pter
End:
23,035,230 bp from pter
Size:
18,688 bases
Orientation:
Minus strand

Genomic View for PSMB5 Gene

Genes around PSMB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB5 Gene

Proteins for PSMB5 Gene

  • Protein details for PSMB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28074-PSB5_HUMAN
    Recommended name:
    Proteasome subunit beta type-5
    Protein Accession:
    P28074
    Secondary Accessions:
    • B2R4N9
    • B4DUM9
    • D3DS43
    • E9PAV2
    • Q16242
    • Q6PEW2
    • Q7Z3B5
    • Q86T01
    • Q9TNN9

    Protein attributes for PSMB5 Gene

    Size:
    263 amino acids
    Molecular mass:
    28480 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. This subunit can be displaced by the equivalent immune-specific subunit PSMB8. Directly interacts with POMP. Interacts with HIV-1 TAT protein. Interacts with ABCB1 and TAP1.
    SequenceCaution:
    • Sequence=AAP35423.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA06097.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD97956.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PSMB5 Gene

    Alternative splice isoforms for PSMB5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMB5 Gene

Selected DME Specific Peptides for PSMB5 Gene

Post-translational modifications for PSMB5 Gene

  • Ubiquitination at Lys 91 and Lys 92
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSMB5 (PSMB5)

Domains & Families for PSMB5 Gene

Gene Families for PSMB5 Gene

Suggested Antigen Peptide Sequences for PSMB5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28074

UniProtKB/Swiss-Prot:

PSB5_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB5: view

Function for PSMB5 Gene

Molecular function for PSMB5 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta,subunit MB-1/X,22.9kDa
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib. May catalyze basal processing of intracellular antigens. Plays a role in the protection against oxidative damage through the Nrf2-ARE pathway (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated by IFNG/IFN-gamma (at protein level). Induced in breast cancer tissue. Up-regulated by sulforaphane in breast cancer cells.

Enzyme Numbers (IUBMB) for PSMB5 Gene

Gene Ontology (GO) - Molecular Function for PSMB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 14733938
GO:0008233 peptidase activity IDA 17540904
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMB5: view
genes like me logo Genes that share phenotypes with PSMB5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PSMB5

miRNA for PSMB5 Gene

miRTarBase miRNAs that target PSMB5

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMB5 Gene

Localization for PSMB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMB5 Gene COMPARTMENTS Subcellular localization image for PSMB5 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 5
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PSMB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA,TAS 17323924
GO:0005634 nucleus IEA,IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with PSMB5: view

Pathways & Interactions for PSMB5 Gene

SuperPathways for PSMB5 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
.78
.32
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMB5: view

Gene Ontology (GO) - Biological Process for PSMB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IDA 17540904
genes like me logo Genes that share ontologies with PSMB5: view

No data available for SIGNOR curated interactions for PSMB5 Gene

Drugs & Compounds for PSMB5 Gene

(21) Drugs for PSMB5 Gene - From: DrugBank, ApexBio, DGIdb, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other, Target Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 794
carfilzomib Approved Pharma other, Inhibitor, Target Other, 20S Proteasome Inhibitor 0
Kyprolis Approved July 2012 Pharma 0
Velcade Approved May 2003 Pharma 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0

(14) ApexBio Compounds for PSMB5 Gene

Compound Action Cas Number
AM 114 20S proteasome inhibitor 856849-35-9
Bortezomib (PS-341) Proteasome Inhibitor 179324-69-7
Carfilzomib (PR-171) Proteasome inhibitor,epoxomicin analog 868540-17-4
Celastrol Antioxidant, anti-inflammatory and immunosuppressive agent 34157-83-0
CEP-18770 Proteasome inhibitor 847499-27-8
Dihydroeponemycin Proteasome inhibitor,antitumor reagent,eponemycin ddrivative 126463-64-7
Epoxomicin Proteasome inhibitor 134381-21-8
MG-132 Proteasome inhibitor, Cell permeable, reversible 133407-82-6
MLN2238 β5 site of the 20S proteasome inhibitor 1072833-77-2
MLN9708 Proteasome inhibitor 1201902-80-8
ONX-0914 (PR-957) Immunoproteasome inhibitor,potent and selective 960374-59-8
Oprozomib (ONX-0912) Proteasome inhibitor 935888-69-0
PI-1840 Chymotrypsin-like (CT-L) inhibitor 1401223-22-0
PSI Proteasome inhibitor 158442-41-2
genes like me logo Genes that share compounds with PSMB5: view

Transcripts for PSMB5 Gene

Unigene Clusters for PSMB5 Gene

Proteasome (prosome, macropain) subunit, beta type, 5:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for PSMB5 Gene

GeneLoc Exon Structure for
PSMB5
ECgene alternative splicing isoforms for
PSMB5

Expression for PSMB5 Gene

mRNA expression in normal human tissues for PSMB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMB5 Gene

This gene is overexpressed in Liver, secretome (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMB5 Gene



Protein tissue co-expression partners for PSMB5 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSMB5 Gene:

PSMB5

SOURCE GeneReport for Unigene cluster for PSMB5 Gene:

Hs.422990
genes like me logo Genes that share expression patterns with PSMB5: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMB5 Gene

Orthologs for PSMB5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMB5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMB5 34 35
  • 92.24 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMB5 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMB5 34 35
  • 91.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PSMB5 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmb5 34 16 35
  • 88.67 (n)
rat
(Rattus norvegicus)
Mammalia Psmb5 34
  • 88.47 (n)
chimpanzee
(Pan troglodytes)
Mammalia PSMB5 35
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMB5 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb5 34
  • 75.16 (n)
zebrafish
(Danio rerio)
Actinopterygii psmb5 34 35
  • 67.7 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11284 34
fruit fly
(Drosophila melanogaster)
Insecta Prosbeta5 34 35
  • 63.86 (n)
Prosbgr5 36
  • 63 (a)
CG9868 36
  • 57 (a)
CG31742 35
  • 40 (a)
ManyToMany
Prosbeta5R 35
  • 40 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010718 34
  • 60.55 (n)
worm
(Caenorhabditis elegans)
Secernentea pbs-5 34 35
  • 52.4 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE2 35 37
  • 51 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G26340 34
  • 59.32 (n)
rice
(Oryza sativa)
Liliopsida Os06g0153800 34
  • 63.24 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8465 35
  • 62 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1918 34
Species where no ortholog for PSMB5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMB5 Gene

ENSEMBL:
Gene Tree for PSMB5 (if available)
TreeFam:
Gene Tree for PSMB5 (if available)

Paralogs for PSMB5 Gene

Paralogs for PSMB5 Gene

(4) SIMAP similar genes for PSMB5 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PSMB5 Gene

genes like me logo Genes that share paralogs with PSMB5: view

Variants for PSMB5 Gene

Sequence variations from dbSNP and Humsavar for PSMB5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10138759 -- 23,023,067(+) GAGGA(A/G)GATAT intron-variant
rs111412313 -- 23,016,765(+) CTTGC(C/T)CACCC intron-variant
rs112215209 -- 23,023,256(+) CCCTC(C/T)CTTGC intron-variant
rs112368991 -- 23,019,876(+) CTGTA(-/T)TTTTT intron-variant
rs112390315 -- 23,026,711(+) TCCCA(A/G)AGTGC intron-variant

Variation tolerance for PSMB5 Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.73; 57.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMB5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PSMB5 Gene

Disorders for PSMB5 Gene

Relevant External Links for PSMB5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMB5

No disorders were found for PSMB5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMB5 Gene

Publications for PSMB5 Gene

  1. cDNA cloning and interferon gamma down-regulation of proteasomal subunits X and Y. (PMID: 8066462) Akiyama K.-Y. … Ichihara A. (Science 1994) 2 3 4 64
  2. Different mutants of PSMB5 confer varying bortezomib resistance in T lymphoblastic lymphoma/leukemia cells derived from the Jurkat cell line. (PMID: 19426847) Lue S. … Wang J. (Exp. Hematol. 2009) 3 4 64
  3. Down-regulation of proteasomal subunit MB1 is an independent predictor of improved survival in ovarian cancer. (PMID: 19243813) Leffers N. … Nijman H.W. (Gynecol. Oncol. 2009) 3 22 64
  4. Point mutation of the proteasome beta5 subunit gene is an important mechanism of bortezomib resistance in bortezomib-selected variants of Jurkat T cell lymphoblastic lymphoma/leukemia line. (PMID: 18502982) Lue S. … Wang J. (J. Pharmacol. Exp. Ther. 2008) 3 4 64
  5. Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein. (PMID: 18565852) Oerlemans R. … Jansen G. (Blood 2008) 3 4 64

Products for PSMB5 Gene

Sources for PSMB5 Gene