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Aliases for PSMB4 Gene

Aliases for PSMB4 Gene

  • Proteasome Subunit Beta 4 2 3
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 4 2 3
  • Multicatalytic Endopeptidase Complex Beta Chain 3 4
  • 26 KDa Prosomal Protein 3 4
  • Proteasome Beta Chain 3 4
  • Macropain Beta Chain 3 4
  • Proteasome Chain 3 3 4
  • EC 3.4.25.1 4 63
  • HsBPROS26 3 4
  • PROS-26 3 4
  • PROS26 3 4
  • HsN3 3 4
  • Proteasome Subunit, Beta Type, 4 3
  • Proteasome Subunit HsN3 3
  • HN3 3

External Ids for PSMB4 Gene

Previous GeneCards Identifiers for PSMB4 Gene

  • GC01P149213
  • GC01P147119
  • GC01P148147
  • GC01P148588
  • GC01P148185
  • GC01P149610
  • GC01P122750

Summaries for PSMB4 Gene

Entrez Gene Summary for PSMB4 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMB4 Gene

PSMB4 (Proteasome Subunit Beta 4) is a Protein Coding gene. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include threonine-type endopeptidase activity and lipopolysaccharide binding.

UniProtKB/Swiss-Prot for PSMB4 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal macrophage proteasome (By similarity). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.

Gene Wiki entry for PSMB4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB4 Gene

Genomics for PSMB4 Gene

Regulatory Elements for PSMB4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PSMB4 Gene

Chromosome:
1
Start:
151,399,534 bp from pter
End:
151,401,944 bp from pter
Size:
2,411 bases
Orientation:
Plus strand

Genomic View for PSMB4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSMB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB4 Gene

Proteins for PSMB4 Gene

  • Protein details for PSMB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28070-PSB4_HUMAN
    Recommended name:
    Proteasome subunit beta type-4
    Protein Accession:
    P28070
    Secondary Accessions:
    • B2R9L3
    • P31148
    • Q5SZS5
    • Q6IBI4
    • Q969L6

    Protein attributes for PSMB4 Gene

    Size:
    264 amino acids
    Molecular mass:
    29204 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with HIV-1 TAT and HIV-1 NEF proteins. Interaction with HTLV-1 TAX protein favors NFKB1 activation. Interacts with bacterial lipopolysaccharide (LPS) (By similarity). Forms a ternary complex with SMAD1 and OAZ1 before PSMB4 is incorporated into the 20S proteasome. Interacts with PRPF19.

    Three dimensional structures from OCA and Proteopedia for PSMB4 Gene

neXtProt entry for PSMB4 Gene

Proteomics data for PSMB4 Gene at MOPED

Post-translational modifications for PSMB4 Gene

  • Ubiquitination at Lys 109
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for PSMB4 Gene

Gene Families for PSMB4 Gene

Suggested Antigen Peptide Sequences for PSMB4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28070

UniProtKB/Swiss-Prot:

PSB4_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB4: view

Function for PSMB4 Gene

Molecular function for PSMB4 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20s),proteasome (prosome,macropain) component,beta 4 (HSBpros26),29.2kDa
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal macrophage proteasome (By similarity). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.
UniProtKB/Swiss-Prot Induction:
Up-regulated in fibrolamellar carcinomas.

Enzyme Numbers (IUBMB) for PSMB4 Gene

Gene Ontology (GO) - Molecular Function for PSMB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IEA --
GO:0004175 endopeptidase activity IBA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PSMB4: view
genes like me logo Genes that share phenotypes with PSMB4: view

Animal Model Products

miRNA for PSMB4 Gene

miRTarBase miRNAs that target PSMB4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMB4

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PSMB4 Gene

Localization for PSMB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMB4 Gene COMPARTMENTS Subcellular localization image for PSMB4 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for PSMB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 17323924
GO:0005634 nucleus TAS 16130169
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMB4: view

Pathways & Interactions for PSMB4 Gene

SuperPathways for PSMB4 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin receptor SHC signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.53
5 Immune System
genes like me logo Genes that share pathways with PSMB4: view

Gene Ontology (GO) - Biological Process for PSMB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with PSMB4: view

No data available for SIGNOR curated interactions for PSMB4 Gene

Drugs & Compounds for PSMB4 Gene

(3) Drugs for PSMB4 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other, Target Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 758
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMB4: view

Transcripts for PSMB4 Gene

Unigene Clusters for PSMB4 Gene

Proteasome (prosome, macropain) subunit, beta type, 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMB4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: -
SP6: - - - -
SP7: -
SP8:
SP9: -

Relevant External Links for PSMB4 Gene

GeneLoc Exon Structure for
PSMB4
ECgene alternative splicing isoforms for
PSMB4

Expression for PSMB4 Gene

mRNA expression in normal human tissues for PSMB4 Gene

Protein differential expression in normal tissues from HIPED for PSMB4 Gene

This gene is overexpressed in Liver, secretome (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMB4 Gene



SOURCE GeneReport for Unigene cluster for PSMB4 Gene Hs.89545

genes like me logo Genes that share expression patterns with PSMB4: view

Protein tissue co-expression partners for PSMB4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMB4 Gene

Orthologs for PSMB4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMB4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMB4 35
  • 90.91 (n)
  • 95.08 (a)
PSMB4 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMB4 35
  • 89.65 (n)
  • 92.05 (a)
PSMB4 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmb4 35
  • 87.88 (n)
  • 93.94 (a)
Psmb4 16
Psmb4 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSMB4 35
  • 99.75 (n)
  • 99.62 (a)
PSMB4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmb4 35
  • 87.21 (n)
  • 93.1 (a)
oppossum
(Monodelphis domestica)
Mammalia PSMB4 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMB4 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMB4 35
  • 72.87 (n)
  • 76.11 (a)
PSMB4 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMB4 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb4 35
  • 71.26 (n)
  • 77.73 (a)
Str.129 35
African clawed frog
(Xenopus laevis)
Amphibia psmb4-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15385 35
psmb4 35
  • 74.42 (n)
  • 79.53 (a)
psmb4 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12000 37
  • 39 (a)
Prosbeta7 35
  • 51.46 (n)
  • 40.87 (a)
Prosbeta7 36
  • 37 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011444 35
  • 54.28 (n)
  • 47.83 (a)
worm
(Caenorhabditis elegans)
Secernentea pbs-7 36
  • 33 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR258W 35
  • 55.16 (n)
  • 46.19 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D11506g 35
  • 51.34 (n)
  • 43.75 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE4 35
  • 51.65 (n)
  • 45.05 (a)
PRE4 36
  • 39 (a)
OneToOne
PRE4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PBG1 35
  • 53.55 (n)
  • 46.45 (a)
rice
(Oryza sativa)
Liliopsida Os09g0515200 35
  • 50.68 (n)
  • 44.34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4701 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07365 35
  • 50.75 (n)
  • 44.59 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC577.10 35
  • 49.85 (n)
  • 43.69 (a)
Species with no ortholog for PSMB4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMB4 Gene

ENSEMBL:
Gene Tree for PSMB4 (if available)
TreeFam:
Gene Tree for PSMB4 (if available)

Paralogs for PSMB4 Gene

No data available for Paralogs for PSMB4 Gene

Variants for PSMB4 Gene

Sequence variations from dbSNP and Humsavar for PSMB4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4603 - 151,401,549(+) TCAAA(C/T)CGCCA missense, reference
rs7172 -- 151,399,662(+) ATTCC(A/G)TCCAC synonymous-codon, reference
rs14276 -- 151,400,544(+) AACCC(C/T)TTGTG synonymous-codon, reference
rs1052721 -- 151,400,650(+) GTATC(C/T)CTTCT intron-variant
rs1804239 -- 151,400,812(+) CCTTC(A/G)CTGGC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for PSMB4 Gene

Variant ID Type Subtype PubMed ID
esv34461 CNV Gain 17911159
nsv831581 CNV Loss 17160897
dgv386n71 CNV Gain 21882294
dgv128e1 CNV Complex 17122850
nsv872428 CNV Gain 21882294
nsv8380 CNV Gain 18304495
nsv824575 CNV Gain 20364138
nsv470737 CNV Gain 18288195
nsv818467 CNV Gain 17921354
dgv36n27 CNV Gain 19166990
nsv441714 CNV CNV 18776908
nsv872436 CNV Gain 21882294
dgv387n71 CNV Gain 21882294

Variation tolerance for PSMB4 Gene

Residual Variation Intolerance Score: 22.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.60; 82.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMB4 Gene

HapMap Linkage Disequilibrium report
PSMB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMB4 Gene

Disorders for PSMB4 Gene

Relevant External Links for PSMB4

Genetic Association Database (GAD)
PSMB4
Human Genome Epidemiology (HuGE) Navigator
PSMB4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMB4
genes like me logo Genes that share disorders with PSMB4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMB4 Gene

Publications for PSMB4 Gene

  1. Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues. (PMID: 7918633) Nothwang H.G. … Ichihara A. (Biochim. Biophys. Acta 1994) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. PSMB4 promotes multiple myeloma cell growth by activating NF-I_B-miR-21 signaling. (PMID: 25656574) Zheng P. … Liu Y. (Biochem. Biophys. Res. Commun. 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67

Products for PSMB4 Gene

Sources for PSMB4 Gene

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