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Aliases for PSMB3 Gene

Aliases for PSMB3 Gene

  • Proteasome Subunit Beta 3 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 3 2 3
  • Proteasome Component C10-II 3 4
  • Proteasome Theta Chain 3 4
  • Proteasome Chain 13 3 4
  • EC 3.4.25.1 4 56
  • Proteasome Subunit Beta Type-3 3
  • HC10-II 3

External Ids for PSMB3 Gene

Previous GeneCards Identifiers for PSMB3 Gene

  • GC17P036394
  • GC17P038902
  • GC17P036819
  • GC17P037284
  • GC17P037285
  • GC17P034162
  • GC17P036909
  • GC17P032705

Summaries for PSMB3 Gene

Entrez Gene Summary for PSMB3 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants [provided by RefSeq, Sep 2013]

GeneCards Summary for PSMB3 Gene

PSMB3 (Proteasome Subunit Beta 3) is a Protein Coding gene. Diseases associated with PSMB3 include Cystic Fibrosis. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include threonine-type endopeptidase activity.

UniProtKB/Swiss-Prot for PSMB3 Gene

  • Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).

Gene Wiki entry for PSMB3 Gene

Additional gene information for PSMB3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB3 Gene

Genomics for PSMB3 Gene

GeneHancer (GH) Regulatory Elements for PSMB3 Gene

Promoters and enhancers for PSMB3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I038745 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 558.1 -2.9 -2940 8.6 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PCGF2 PSMB3 LOC100287808 MED1 CDK12 LOC105371762 SNORA21 RPL23 RPL19 CISD3
GH17I038867 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16 +119.0 118990 9.2 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF548 SP3 LASP1 MED1 CDK12 SNORA21 LOC105371762 RPL23 CWC25 PSMB3 SNORA21B C17orf98
GH17I038724 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12 -23.3 -23251 10.8 HDGF CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CISD3 ENSG00000279119 PCGF2 MED1 CDK12 RPL23 LOC105371762 MLLT6 PGAP3 STARD3
GH17I038673 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.1 -78.0 -77991 1.7 CLOCK MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 SP3 GC17M038673 EPOP PCGF2 PIP4K2B MLLT6 CISD3 PSMB3 CWC25
GH17I038823 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 8.2 +72.2 72225 3 MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC CWC25 MIR4727 MED1 CDK12 SNORA21 LOC105371762 RPL23 STARD3 RPL19 PIP4K2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PSMB3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSMB3 gene promoter:

Genomic Locations for PSMB3 Gene

Genomic Locations for PSMB3 Gene
chr17:38,752,713-38,764,231
(GRCh38/hg38)
Size:
11,519 bases
Orientation:
Plus strand
chr17:36,908,989-36,920,484
(GRCh37/hg19)

Genomic View for PSMB3 Gene

Genes around PSMB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB3 Gene

Proteins for PSMB3 Gene

  • Protein details for PSMB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49720-PSB3_HUMAN
    Recommended name:
    Proteasome subunit beta type-3
    Protein Accession:
    P49720
    Secondary Accessions:
    • P31147
    • Q0P6J7
    • Q96E27

    Protein attributes for PSMB3 Gene

    Size:
    205 amino acids
    Molecular mass:
    22949 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Interacts with HIV-1 TAT protein (PubMed:14550573).

    Three dimensional structures from OCA and Proteopedia for PSMB3 Gene

neXtProt entry for PSMB3 Gene

Selected DME Specific Peptides for PSMB3 Gene

P49720:
  • EPVIAGLDPKTF
  • GLATDVQT
  • RFGIQAQ
  • LYEKRFGP
  • PFICSLDLIGCPMVT
  • GKNCVAIA
  • QRLKFRLNLYELKEGRQIKP
  • LFETISQ
  • CVAIAADRRFG

Post-translational modifications for PSMB3 Gene

  • Ubiquitination at Lys17 and isoforms=77

Other Protein References for PSMB3 Gene

Domains & Families for PSMB3 Gene

Gene Families for PSMB3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PSMB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49720

UniProtKB/Swiss-Prot:

PSB3_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB3: view

Function for PSMB3 Gene

Molecular function for PSMB3 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20s),proteasome component beta 3 (HSC10-I1),22.9kDa
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
UniProtKB/Swiss-Prot Induction:
Up-regulated in asthenozoospermic sperm.

Enzyme Numbers (IUBMB) for PSMB3 Gene

Phenotypes From GWAS Catalog for PSMB3 Gene

Gene Ontology (GO) - Molecular Function for PSMB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 14733938
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMB3: view
genes like me logo Genes that share phenotypes with PSMB3: view

miRNA for PSMB3 Gene

miRTarBase miRNAs that target PSMB3

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMB3 Gene

Localization for PSMB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMB3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 3
cytoskeleton 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PSMB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA,TAS 17323924
GO:0005634 nucleus IEA,HDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMB3: view

Pathways & Interactions for PSMB3 Gene

SuperPathways for PSMB3 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMB3: view

Gene Ontology (GO) - Biological Process for PSMB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PSMB3: view

No data available for SIGNOR curated interactions for PSMB3 Gene

Drugs & Compounds for PSMB3 Gene

(3) Drugs for PSMB3 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 826
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMB3: view

Transcripts for PSMB3 Gene

mRNA/cDNA for PSMB3 Gene

Unigene Clusters for PSMB3 Gene

Proteasome (prosome, macropain) subunit, beta type, 3:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB3 Gene

No ASD Table

Relevant External Links for PSMB3 Gene

GeneLoc Exon Structure for
PSMB3
ECgene alternative splicing isoforms for
PSMB3

Expression for PSMB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSMB3 Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for PSMB3 Gene

This gene is overexpressed in Liver, secretome (8.0) and Tlymphocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMB3 Gene



Protein tissue co-expression partners for PSMB3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMB3 Gene:

PSMB3

SOURCE GeneReport for Unigene cluster for PSMB3 Gene:

Hs.82793

Evidence on tissue expression from TISSUES for PSMB3 Gene

  • Muscle(4.5)
  • Nervous system(4.5)
  • Liver(4.4)
  • Skin(4.4)
  • Heart(2.1)
  • Lung(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with PSMB3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMB3 Gene

Orthologs for PSMB3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMB3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PSMB3 33
  • 94.31 (n)
cow
(Bos Taurus)
Mammalia PSMB3 33
  • 93.98 (n)
rat
(Rattus norvegicus)
Mammalia Psmb3 33
  • 91.22 (n)
mouse
(Mus musculus)
Mammalia Psmb3 33 16
  • 91.06 (n)
chicken
(Gallus gallus)
Aves PSMB3 33
  • 81.95 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb3 33
  • 81.95 (n)
Str.1505 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.20003 33
zebrafish
(Danio rerio)
Actinopterygii psmb3 33
  • 80 (n)
Dr.5594 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11891 33
fruit fly
(Drosophila melanogaster)
Insecta Prosbeta3 33
  • 67.8 (n)
Prosbgr3 35
  • 63 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001697 33
  • 66.83 (n)
worm
(Caenorhabditis elegans)
Secernentea pbs-3 33
  • 55.23 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR217C 33
  • 59.83 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUP3 33
  • 59.33 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20197g 33
  • 55.67 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PBC1 33
  • 58.17 (n)
soybean
(Glycine max)
eudicotyledons Gma.323 33
rice
(Oryza sativa)
Liliopsida Os06g0643100 33
  • 58.99 (n)
Os.3708 33
barley
(Hordeum vulgare)
Liliopsida Hv.1499 33
wheat
(Triticum aestivum)
Liliopsida Ta.14429 33
corn
(Zea mays)
Liliopsida Zm.1066 33
bread mold
(Neurospora crassa)
Ascomycetes NCU03304 33
  • 60.91 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pup3 33
  • 56.21 (n)
Species where no ortholog for PSMB3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMB3 Gene

ENSEMBL:
Gene Tree for PSMB3 (if available)
TreeFam:
Gene Tree for PSMB3 (if available)

Paralogs for PSMB3 Gene

Pseudogenes.org Pseudogenes for PSMB3 Gene

genes like me logo Genes that share paralogs with PSMB3: view

No data available for Paralogs for PSMB3 Gene

Variants for PSMB3 Gene

Sequence variations from dbSNP and Humsavar for PSMB3 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000038767 -- 38,762,978(+) A/T intron_variant
rs1000090576 -- 38,763,173(+) C/G intron_variant
rs1000132343 -- 38,752,274(+) T/G upstream_transcript_variant
rs1000144671 -- 38,763,418(+) A/AA intron_variant
rs1000172579 -- 38,761,368(+) T/A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PSMB3 Gene

Variant ID Type Subtype PubMed ID
nsv1134645 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv470585 CNV loss 18288195
nsv833438 CNV loss 17160897
nsv833439 CNV loss 17160897

Variation tolerance for PSMB3 Gene