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Aliases for PSMB3 Gene

Aliases for PSMB3 Gene

  • Proteasome Subunit Beta 3 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 3 2 3
  • Proteasome Component C10-II 3 4
  • Proteasome Theta Chain 3 4
  • Proteasome Chain 13 3 4
  • EC 3.4.25.1 4 61
  • Proteasome Subunit Beta Type-3 3
  • HC10-II 3

External Ids for PSMB3 Gene

Previous GeneCards Identifiers for PSMB3 Gene

  • GC17P036394
  • GC17P038902
  • GC17P036819
  • GC17P037284
  • GC17P037285
  • GC17P034162
  • GC17P036909
  • GC17P032705

Summaries for PSMB3 Gene

Entrez Gene Summary for PSMB3 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants [provided by RefSeq, Sep 2013]

GeneCards Summary for PSMB3 Gene

PSMB3 (Proteasome Subunit Beta 3) is a Protein Coding gene. Diseases associated with PSMB3 include Cystic Fibrosis. Among its related pathways are RET signaling and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include threonine-type endopeptidase activity.

UniProtKB/Swiss-Prot for PSMB3 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Gene Wiki entry for PSMB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB3 Gene

Genomics for PSMB3 Gene

Regulatory Elements for PSMB3 Gene

Enhancers for PSMB3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F038867 1.6 FANTOM5 ENCODE 15.9 +119.0 118991 9.2 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 CDK12 ENSG00000266469 MED1 ENSG00000275665 SNORA21 ENSG00000275532 CWC25 LINC02079 PSMB3 ENSG00000252699
GH17F038677 1.3 Ensembl ENCODE 11 -75.6 -75612 1.0 ATF1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 GATA2 ZNF143 ZNF207 MLLT6 PCGF2 CISD3 PIP4K2B PSMB3 CWC25 EPOP GC17M038684
GH17F038876 1.3 Ensembl ENCODE 10.9 +129.4 129436 11.1 PKNOX1 ZFP64 SIN3A ARID4B FEZF1 GLI4 ETS1 ZNF121 GLIS2 SP5 RPL23 RPS20P35 SNORA21 ENSG00000252699 C17orf98 CWC25 PSMB3 LASP1 PCGF2 PPP1R1B
GH17F038724 1.1 ENCODE 12 -23.3 -23251 10.8 HDGF ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ZNF207 PAF1 PCGF2 MLLT6 LINC02079 PGAP3 PSMB3 CWC25 CISD3 STAC2 ENSG00000279119
GH17F038718 1.1 Ensembl ENCODE 11.7 -33.0 -33040 2.6 ATF1 PKNOX1 SCRT2 FOS CREM SP3 SP5 NFYA NFYC USF2 PCGF2 PSMB3 MIR4726 ENSG00000275532
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSMB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSMB3 Gene

Chromosome:
17
Start:
38,752,713 bp from pter
End:
38,764,231 bp from pter
Size:
11,519 bases
Orientation:
Plus strand

Genomic View for PSMB3 Gene

Genes around PSMB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB3 Gene

Proteins for PSMB3 Gene

  • Protein details for PSMB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49720-PSB3_HUMAN
    Recommended name:
    Proteasome subunit beta type-3
    Protein Accession:
    P49720
    Secondary Accessions:
    • P31147
    • Q0P6J7
    • Q96E27

    Protein attributes for PSMB3 Gene

    Size:
    205 amino acids
    Molecular mass:
    22949 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with HIV-1 TAT protein.

    Three dimensional structures from OCA and Proteopedia for PSMB3 Gene

neXtProt entry for PSMB3 Gene

Selected DME Specific Peptides for PSMB3 Gene

P49720:
  • EPVIAGLDPKTF
  • GLATDVQT
  • RFGIQAQ
  • LYEKRFGP
  • PFICSLDLIGCPMVT
  • GKNCVAIA
  • QRLKFRLNLYELKEGRQIKP
  • LFETISQ
  • CVAIAADRRFG

Post-translational modifications for PSMB3 Gene

  • Ubiquitination at Lys 17 and Lys 77
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB3 Gene

Domains & Families for PSMB3 Gene

Gene Families for PSMB3 Gene

Suggested Antigen Peptide Sequences for PSMB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49720

UniProtKB/Swiss-Prot:

PSB3_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB3: view

Function for PSMB3 Gene

Molecular function for PSMB3 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20s),proteasome component beta 3 (HSC10-I1),22.9kDa
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
UniProtKB/Swiss-Prot Induction:
Up-regulated in asthenozoospermic sperm.

Enzyme Numbers (IUBMB) for PSMB3 Gene

Gene Ontology (GO) - Molecular Function for PSMB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 14733938
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMB3: view
genes like me logo Genes that share phenotypes with PSMB3: view

Animal Model Products

miRNA for PSMB3 Gene

miRTarBase miRNAs that target PSMB3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMB3 Gene

Localization for PSMB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMB3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 3
cytoskeleton 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for PSMB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA,TAS 17323924
GO:0005634 nucleus IEA,IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with PSMB3: view

Pathways & Interactions for PSMB3 Gene

SuperPathways for PSMB3 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
.78
.32
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMB3: view

Gene Ontology (GO) - Biological Process for PSMB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PSMB3: view

No data available for SIGNOR curated interactions for PSMB3 Gene

Drugs & Compounds for PSMB3 Gene

(3) Drugs for PSMB3 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 794
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMB3: view

Transcripts for PSMB3 Gene

Unigene Clusters for PSMB3 Gene

Proteasome (prosome, macropain) subunit, beta type, 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB3 Gene

No ASD Table

Relevant External Links for PSMB3 Gene

GeneLoc Exon Structure for
PSMB3
ECgene alternative splicing isoforms for
PSMB3

Expression for PSMB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSMB3 Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for PSMB3 Gene

This gene is overexpressed in Liver, secretome (8.0) and Tlymphocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMB3 Gene



Protein tissue co-expression partners for PSMB3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMB3 Gene:

PSMB3

SOURCE GeneReport for Unigene cluster for PSMB3 Gene:

Hs.82793
genes like me logo Genes that share expression patterns with PSMB3: view

No data available for mRNA Expression by UniProt/SwissProt for PSMB3 Gene

Orthologs for PSMB3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMB3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PSMB3 34
  • 94.31 (n)
cow
(Bos Taurus)
Mammalia PSMB3 34
  • 93.98 (n)
rat
(Rattus norvegicus)
Mammalia Psmb3 34
  • 91.22 (n)
mouse
(Mus musculus)
Mammalia Psmb3 34 16
  • 91.06 (n)
chicken
(Gallus gallus)
Aves PSMB3 34
  • 81.95 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb3 34
  • 81.95 (n)
Str.1505 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.20003 34
zebrafish
(Danio rerio)
Actinopterygii psmb3 34
  • 80 (n)
Dr.5594 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11891 34
fruit fly
(Drosophila melanogaster)
Insecta Prosbeta3 34
  • 67.8 (n)
Prosbgr3 36
  • 63 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001697 34
  • 66.83 (n)
worm
(Caenorhabditis elegans)
Secernentea pbs-3 34
  • 55.23 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR217C 34
  • 59.83 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUP3 34
  • 59.33 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20197g 34
  • 55.67 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PBC1 34
  • 58.17 (n)
soybean
(Glycine max)
eudicotyledons Gma.323 34
rice
(Oryza sativa)
Liliopsida Os06g0643100 34
  • 58.99 (n)
Os.3708 34
barley
(Hordeum vulgare)
Liliopsida Hv.1499 34
wheat
(Triticum aestivum)
Liliopsida Ta.14429 34
corn
(Zea mays)
Liliopsida Zm.1066 34
bread mold
(Neurospora crassa)
Ascomycetes NCU03304 34
  • 60.91 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pup3 34
  • 56.21 (n)
Species where no ortholog for PSMB3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMB3 Gene

ENSEMBL:
Gene Tree for PSMB3 (if available)
TreeFam:
Gene Tree for PSMB3 (if available)

Paralogs for PSMB3 Gene

Pseudogenes.org Pseudogenes for PSMB3 Gene

genes like me logo Genes that share paralogs with PSMB3: view

No data available for Paralogs for PSMB3 Gene

Variants for PSMB3 Gene

Sequence variations from dbSNP and Humsavar for PSMB3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11079060 -- 38,756,583(+) CTCCA(C/G)CTCCC intron-variant
rs111273560 -- 38,759,145(+) GTTAT(C/T)TGGTA intron-variant
rs111276057 -- 38,752,831(+) CATGG(A/C/T)GAGAT splice-donor-variant
rs111393142 -- 38,753,335(+) ACAGT(C/G/T)TAAGT splice-donor-variant
rs111684371 -- 38,764,136(+) AATCA(A/C/G)CACCA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PSMB3 Gene

Variant ID Type Subtype PubMed ID
nsv1134645 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv470585 CNV loss 18288195
nsv833438 CNV loss 17160897
nsv833439 CNV loss 17160897

Variation tolerance for PSMB3 Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.08; 80.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMB3 Gene

Disorders for PSMB3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSMB3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
- elite association - COSMIC cancer census association via MalaCards
Search PSMB3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSMB3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMB3
genes like me logo Genes that share disorders with PSMB3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMB3 Gene

Publications for PSMB3 Gene

  1. Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues. (PMID: 7918633) Nothwang H.G. … Ichihara A. (Biochim. Biophys. Acta 1994) 2 3 4 64
  2. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X. … Huang L. (Biochemistry 2007) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. (PMID: 14550573) Apcher G.S. … Krueger E. (FEBS Lett. 2003) 3 4 64
  5. Human proteasome subunits from 2-dimensional gels identified by partial sequencing. (PMID: 7811265) Kristensen P. … Hendil K.B. (Biochem. Biophys. Res. Commun. 1994) 3 4 64

Products for PSMB3 Gene

Sources for PSMB3 Gene

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