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Aliases for PSMB3 Gene

Aliases for PSMB3 Gene

  • Proteasome Subunit Beta 3 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 3 2 3
  • Proteasome Component C10-II 3 4
  • Proteasome Theta Chain 3 4
  • Proteasome Chain 13 3 4
  • EC 3.4.25.1 4 63
  • HC10-II 3

External Ids for PSMB3 Gene

Previous GeneCards Identifiers for PSMB3 Gene

  • GC17P036394
  • GC17P038902
  • GC17P036819
  • GC17P037284
  • GC17P037285
  • GC17P034162
  • GC17P036909
  • GC17P032705

Summaries for PSMB3 Gene

Entrez Gene Summary for PSMB3 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants [provided by RefSeq, Sep 2013]

GeneCards Summary for PSMB3 Gene

PSMB3 (Proteasome Subunit Beta 3) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include threonine-type endopeptidase activity.

UniProtKB/Swiss-Prot for PSMB3 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Gene Wiki entry for PSMB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB3 Gene

Genomics for PSMB3 Gene

Regulatory Elements for PSMB3 Gene

Genomic Location for PSMB3 Gene

Chromosome:
17
Start:
38,752,713 bp from pter
End:
38,764,231 bp from pter
Size:
11,519 bases
Orientation:
Plus strand

Genomic View for PSMB3 Gene

Genes around PSMB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB3 Gene

Proteins for PSMB3 Gene

  • Protein details for PSMB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49720-PSB3_HUMAN
    Recommended name:
    Proteasome subunit beta type-3
    Protein Accession:
    P49720
    Secondary Accessions:
    • P31147
    • Q0P6J7
    • Q96E27

    Protein attributes for PSMB3 Gene

    Size:
    205 amino acids
    Molecular mass:
    22949 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with HIV-1 TAT protein.

    Three dimensional structures from OCA and Proteopedia for PSMB3 Gene

neXtProt entry for PSMB3 Gene

Proteomics data for PSMB3 Gene at MOPED

Post-translational modifications for PSMB3 Gene

  • Ubiquitination at Lys 17 and Lys 77
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB3 Gene

Antibody Products

Domains & Families for PSMB3 Gene

Gene Families for PSMB3 Gene

Protein Domains for PSMB3 Gene

Suggested Antigen Peptide Sequences for PSMB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49720

UniProtKB/Swiss-Prot:

PSB3_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB3: view

Function for PSMB3 Gene

Molecular function for PSMB3 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20s),proteasome component beta 3 (HSC10-I1),22.9kDa
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
UniProtKB/Swiss-Prot Induction:
Up-regulated in asthenozoospermic sperm.

Enzyme Numbers (IUBMB) for PSMB3 Gene

genes like me logo Genes that share phenotypes with PSMB3: view

Animal Model Products

miRNA for PSMB3 Gene

miRTarBase miRNAs that target PSMB3

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMB3 Gene

Localization for PSMB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMB3 Gene COMPARTMENTS Subcellular localization image for PSMB3 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
golgi apparatus 5
mitochondrion 5
nucleus 5

Gene Ontology (GO) - Cellular Components for PSMB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PSMB3: view

Pathways & Interactions for PSMB3 Gene

SuperPathways for PSMB3 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin-3, 5 and GM-CSF signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.48
5 Immune System
genes like me logo Genes that share pathways with PSMB3: view

Gene Ontology (GO) - Biological Process for PSMB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSMB3: view

No data available for SIGNOR curated interactions for PSMB3 Gene

Drugs & Compounds for PSMB3 Gene

(3) Drugs for PSMB3 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other, Target Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 769
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMB3: view

Transcripts for PSMB3 Gene

Unigene Clusters for PSMB3 Gene

Proteasome (prosome, macropain) subunit, beta type, 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB3 Gene

No ASD Table

Relevant External Links for PSMB3 Gene

GeneLoc Exon Structure for
PSMB3
ECgene alternative splicing isoforms for
PSMB3

Expression for PSMB3 Gene

mRNA expression in normal human tissues for PSMB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSMB3 Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for PSMB3 Gene

This gene is overexpressed in Liver, secretome (8.0) and Tlymphocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PSMB3 Gene



SOURCE GeneReport for Unigene cluster for PSMB3 Gene Hs.82793

genes like me logo Genes that share expression patterns with PSMB3: view

Protein tissue co-expression partners for PSMB3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PSMB3 Gene

Orthologs for PSMB3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMB3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMB3 35
  • 93.98 (n)
  • 99.02 (a)
dog
(Canis familiaris)
Mammalia PSMB3 35
  • 94.31 (n)
  • 99.02 (a)
mouse
(Mus musculus)
Mammalia Psmb3 35
  • 91.06 (n)
  • 98.54 (a)
Psmb3 16
rat
(Rattus norvegicus)
Mammalia Psmb3 35
  • 91.22 (n)
  • 98.54 (a)
chicken
(Gallus gallus)
Aves PSMB3 35
  • 81.95 (n)
  • 91.71 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20003 35
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb3 35
  • 81.95 (n)
  • 91.22 (a)
Str.1505 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11891 35
zebrafish
(Danio rerio)
Actinopterygii Dr.5594 35
psmb3 35
  • 80 (n)
  • 90.24 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001697 35
  • 66.83 (n)
  • 64.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta Prosbgr3 37
  • 63 (a)
Prosbeta3 35
  • 67.8 (n)
  • 63.9 (a)
worm
(Caenorhabditis elegans)
Secernentea pbs-3 35
  • 55.23 (n)
  • 51.47 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR217C 35
  • 59.83 (n)
  • 53.5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUP3 35
  • 59.33 (n)
  • 55 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20197g 35
  • 55.67 (n)
  • 55 (a)
soybean
(Glycine max)
eudicotyledons Gma.323 35
thale cress
(Arabidopsis thaliana)
eudicotyledons PBC1 35
  • 58.17 (n)
  • 57.84 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.1499 35
corn
(Zea mays)
Liliopsida Zm.1066 35
rice
(Oryza sativa)
Liliopsida Os.3708 35
Os06g0643100 35
  • 58.99 (n)
  • 57.35 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14429 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03304 35
  • 60.91 (n)
  • 59.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pup3 35
  • 56.21 (n)
  • 56.37 (a)
Species with no ortholog for PSMB3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMB3 Gene

ENSEMBL:
Gene Tree for PSMB3 (if available)
TreeFam:
Gene Tree for PSMB3 (if available)

Paralogs for PSMB3 Gene

No data available for Paralogs for PSMB3 Gene

Variants for PSMB3 Gene

Sequence variations from dbSNP and Humsavar for PSMB3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs4907 - 38,753,246(+) CCCAG(A/T)TGGTG nc-transcript-variant, reference, missense
rs228274 -- 38,752,808(+) GAGGG(A/G)TCCTA nc-transcript-variant, utr-variant-5-prime
rs228279 -- 38,762,097(+) CTAAA(C/T)AGGGA intron-variant
rs228280 -- 38,762,298(+) TTCAG(G/T)CATGT intron-variant
rs65926 -- 38,760,180(+) AGGAG(C/G)ACAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMB3 Gene

Variant ID Type Subtype PubMed ID
nsv833438 CNV Loss 17160897
nsv470585 CNV Loss 18288195
nsv833439 CNV Loss 17160897

Variation tolerance for PSMB3 Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.08; 80.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMB3 Gene

HapMap Linkage Disequilibrium report
PSMB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMB3 Gene

Disorders for PSMB3 Gene

Relevant External Links for PSMB3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMB3

No disorders were found for PSMB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMB3 Gene

Publications for PSMB3 Gene

  1. Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues. (PMID: 7918633) Nothwang H.G. … Ichihara A. (Biochim. Biophys. Acta 1994) 2 3 4 67
  2. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for PSMB3 Gene

Sources for PSMB3 Gene

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