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Aliases for PSMB2 Gene

Aliases for PSMB2 Gene

  • Proteasome Subunit Beta 2 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 2 2 3
  • Multicatalytic Endopeptidase Complex Subunit C7-I 3 4
  • Proteasome Component C7-I 3 4
  • Macropain Subunit C7-I 3 4
  • EC 3.4.25.1 4 61
  • Multicatalytic Endopeptidase Complex Subunit C7-1 3
  • Proteasome Subunit, Beta Type, 2 3
  • Testicular Tissue Protein Li 152 3
  • Proteasome Subunit Beta Type-2 3
  • Proteasome Beta 2 Subunit 3
  • HC7-I 3

External Ids for PSMB2 Gene

Previous GeneCards Identifiers for PSMB2 Gene

  • GC01M035888
  • GC01M035124
  • GC01M035494
  • GC01M035496
  • GC01M035737
  • GC01M035815
  • GC01M035841
  • GC01M036042
  • GC01M034187

Summaries for PSMB2 Gene

Entrez Gene Summary for PSMB2 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for PSMB2 Gene

PSMB2 (Proteasome Subunit Beta 2) is a Protein Coding gene. Among its related pathways are RET signaling and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include threonine-type endopeptidase activity.

UniProtKB/Swiss-Prot for PSMB2 Gene

  • Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).

Gene Wiki entry for PSMB2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB2 Gene

Genomics for PSMB2 Gene

Regulatory Elements for PSMB2 Gene

Enhancers for PSMB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G035636 1.2 Ensembl ENCODE 5.2 +3.9 3928 2.4 HDGF HDAC1 TBL1XR1 NFRKB FEZF1 ZBTB40 GATA2 SCRT2 RELB HCFC1 C1orf216 LOC105378645 TFAP2E KIAA0319L NCDN ENSG00000232335 CLSPN PSMB2 DLGAP3 GC01P035622
GH01G035592 0.7 ENCODE 4.6 +48.4 48361 1.5 PKNOX1 ZMYM3 FEZF1 PPARG GABPA ZFHX2 ZNF316 PBX2 ETV4 MAFK PSMB2 LOC105378645 GC01P035622
GH01G035604 0.5 ENCODE 4.7 +36.3 36302 1.5 JUND SIN3A PRDM10 LOC105378645 TFAP2E C1orf216 KIAA0319L NCDN ENSG00000232335 CLSPN PSMB2 GC01P035622
GH01G035640 1.1 ENCODE 0.7 +0.3 334 2.6 PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZMYM1 ENSG00000230163 SFPQ TFAP2E LOC653160 LOC105378647 C1orf216 THRAP3 TRAPPC3 LOC105378645
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSMB2 on UCSC Golden Path with GeneCards custom track

Promoters for PSMB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004696 444 2801 PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for PSMB2 Gene

Chromosome:
1
Start:
35,599,541 bp from pter
End:
35,641,844 bp from pter
Size:
42,304 bases
Orientation:
Minus strand

Genomic View for PSMB2 Gene

Genes around PSMB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB2 Gene

Proteins for PSMB2 Gene

  • Protein details for PSMB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49721-PSB2_HUMAN
    Recommended name:
    Proteasome subunit beta type-2
    Protein Accession:
    P49721
    Secondary Accessions:
    • D3DPS0
    • P31145
    • Q9BWZ9

    Protein attributes for PSMB2 Gene

    Size:
    201 amino acids
    Molecular mass:
    22836 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Interacts with HIV-1 TAT protein (PubMed:14550573).

    Three dimensional structures from OCA and Proteopedia for PSMB2 Gene

neXtProt entry for PSMB2 Gene

Selected DME Specific Peptides for PSMB2 Gene

P49721:
  • LYYMDYL
  • GEAGDTVQFAEY
  • AAANFTR

Post-translational modifications for PSMB2 Gene

  • Ubiquitination at isoforms=29, isoforms=34, Lys62, Lys68, isoforms=162, isoforms=169, isoforms=185, and isoforms=198
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB2 Gene

Domains & Families for PSMB2 Gene

Gene Families for PSMB2 Gene

Suggested Antigen Peptide Sequences for PSMB2 Gene

Graphical View of Domain Structure for InterPro Entry

P49721

UniProtKB/Swiss-Prot:

PSB2_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB2: view

Function for PSMB2 Gene

Molecular function for PSMB2 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20s),proteasome (prosome,macropain) component,beta 2 (HSC7-1),22.8kDa
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
UniProtKB/Swiss-Prot Induction:
Up-regulated in ovarian cancer cell lines.

Enzyme Numbers (IUBMB) for PSMB2 Gene

Gene Ontology (GO) - Molecular Function for PSMB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 14733938
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMB2: view
genes like me logo Genes that share phenotypes with PSMB2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PSMB2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMB2 Gene

Localization for PSMB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMB2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PSMB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS,IDA 17323924
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMB2: view

Pathways & Interactions for PSMB2 Gene

SuperPathways for PSMB2 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMB2: view

Gene Ontology (GO) - Biological Process for PSMB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PSMB2: view

No data available for SIGNOR curated interactions for PSMB2 Gene

Drugs & Compounds for PSMB2 Gene

(6) Drugs for PSMB2 Gene - From: DrugBank, DGIdb, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
carfilzomib Approved Pharma other, Inhibitor, Target Other, 20S Proteasome Inhibitor 0
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 807
Kyprolis Approved July 2012 Pharma 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
MLN-9708 Pharma 0
genes like me logo Genes that share compounds with PSMB2: view

Transcripts for PSMB2 Gene

Unigene Clusters for PSMB2 Gene

Proteasome (prosome, macropain) subunit, beta type, 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PSMB2

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - - -
SP2: -
SP3: - -
SP4:
SP5: - -
SP6: -

Relevant External Links for PSMB2 Gene

GeneLoc Exon Structure for
PSMB2
ECgene alternative splicing isoforms for
PSMB2

Expression for PSMB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMB2 Gene

This gene is overexpressed in Nasal epithelium (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMB2 Gene



Protein tissue co-expression partners for PSMB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSMB2 Gene:

PSMB2

SOURCE GeneReport for Unigene cluster for PSMB2 Gene:

Hs.471441

Evidence on tissue expression from TISSUES for PSMB2 Gene

  • Nervous system(4.9)
  • Skin(4.6)
  • Liver(2.4)
  • Lung(2.4)
  • Intestine(2.3)
  • Muscle(2.1)
  • Heart(2)
  • Kidney(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with PSMB2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMB2 Gene

Orthologs for PSMB2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMB2 34 35
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia PSMB2 34 35
  • 93.86 (n)
cow
(Bos Taurus)
Mammalia PSMB2 34 35
  • 93.2 (n)
mouse
(Mus musculus)
Mammalia Psmb2 34 16 35
  • 91.87 (n)
rat
(Rattus norvegicus)
Mammalia Psmb2 34
  • 90.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PSMB2 35
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 87 (a)
OneToMany
-- 35
  • 83 (a)
OneToMany
chicken
(Gallus gallus)
Aves PSMB2 34 35
  • 80.47 (n)
lizard
(Anolis carolinensis)
Reptilia PSMB2 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb2 34
  • 73.91 (n)
zebrafish
(Danio rerio)
Actinopterygii psmb2 34 35
  • 73.37 (n)
Dr.7341 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8242 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008837 34
  • 60 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17331 36 34 35
  • 57.09 (n)
Prosbeta4R2 35
  • 41 (a)
OneToMany
Prosbeta4R1 35
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pbs-4 34 35
  • 47.96 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B11660g 34
  • 53.02 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE1 34 35 37
  • 51.99 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR019W 34
  • 50.78 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PBD1 34
  • 53.09 (n)
rice
(Oryza sativa)
Liliopsida Os03g0695600 34
  • 52.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2848 35
  • 55 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC31A2.04c 34
  • 50.35 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01368 34
  • 49.47 (n)
Species where no ortholog for PSMB2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMB2 Gene

ENSEMBL:
Gene Tree for PSMB2 (if available)
TreeFam:
Gene Tree for PSMB2 (if available)

Paralogs for PSMB2 Gene

No data available for Paralogs for PSMB2 Gene

Variants for PSMB2 Gene

Sequence variations from dbSNP and Humsavar for PSMB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000034311 -- 35,617,753(+) ACATA(A/C)ACCTG intron-variant
rs1000088666 -- 35,624,323(+) AGCTA(A/G)TATTA intron-variant
rs1000118045 -- 35,639,479(+) AAAAA(A/C)CAACC intron-variant
rs1000170686 -- 35,639,053(+) GTTTG(A/C)GACCA intron-variant
rs1000350174 -- 35,614,527(+) CAAAG(-/TT)TTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMB2 Gene

Variant ID Type Subtype PubMed ID
esv2662513 CNV deletion 23128226
esv2746763 CNV deletion 23290073
esv2746774 CNV deletion 23290073
esv3585723 CNV loss 21293372
nsv1012556 CNV gain 25217958
nsv433 CNV deletion 18451855

Variation tolerance for PSMB2 Gene

Residual Variation Intolerance Score: 51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMB2 Gene

Disorders for PSMB2 Gene

Relevant External Links for PSMB2

Genetic Association Database (GAD)
PSMB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMB2

No disorders were found for PSMB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMB2 Gene

Publications for PSMB2 Gene

  1. Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues. (PMID: 7918633) Nothwang H.G. … Ichihara A. (Biochim. Biophys. Acta 1994) 2 3 4 64
  2. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X. … Huang L. (Biochemistry 2007) 3 4 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. (PMID: 14550573) Apcher G.S. … Krueger E. (FEBS Lett. 2003) 3 4 64

Products for PSMB2 Gene

  • Addgene plasmids for PSMB2

Sources for PSMB2 Gene

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