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Aliases for PSMB2 Gene

Aliases for PSMB2 Gene

  • Proteasome Subunit Beta 2 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 2 2 3
  • Multicatalytic Endopeptidase Complex Subunit C7-I 3 4
  • Proteasome Component C7-I 3 4
  • Macropain Subunit C7-I 3 4
  • EC 3.4.25.1 4 63
  • Multicatalytic Endopeptidase Complex Subunit C7-1 3
  • Proteasome Subunit, Beta Type, 2 3
  • Testicular Tissue Protein Li 152 3
  • Proteasome Beta 2 Subunit 3
  • HC7-I 3

External Ids for PSMB2 Gene

Previous GeneCards Identifiers for PSMB2 Gene

  • GC01M035888
  • GC01M035124
  • GC01M035494
  • GC01M035496
  • GC01M035737
  • GC01M035815
  • GC01M035841
  • GC01M036042
  • GC01M034187

Summaries for PSMB2 Gene

Entrez Gene Summary for PSMB2 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for PSMB2 Gene

PSMB2 (Proteasome Subunit Beta 2) is a Protein Coding gene. Among its related pathways are Cell Cycle Checkpoints and Mitotic Metaphase and Anaphase. GO annotations related to this gene include threonine-type endopeptidase activity.

UniProtKB/Swiss-Prot for PSMB2 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit has a trypsin-like activity.

Gene Wiki entry for PSMB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB2 Gene

Genomics for PSMB2 Gene

Regulatory Elements for PSMB2 Gene

Enhancers for PSMB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSMB2 on UCSC Golden Path with GeneCards custom track

Promoters for PSMB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSMB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSMB2 Gene

Chromosome:
1
Start:
35,599,541 bp from pter
End:
35,641,844 bp from pter
Size:
42,304 bases
Orientation:
Minus strand

Genomic View for PSMB2 Gene

Genes around PSMB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB2 Gene

Proteins for PSMB2 Gene

  • Protein details for PSMB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49721-PSB2_HUMAN
    Recommended name:
    Proteasome subunit beta type-2
    Protein Accession:
    P49721
    Secondary Accessions:
    • D3DPS0
    • P31145
    • Q9BWZ9

    Protein attributes for PSMB2 Gene

    Size:
    201 amino acids
    Molecular mass:
    22836 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with HIV-1 TAT protein.

    Three dimensional structures from OCA and Proteopedia for PSMB2 Gene

neXtProt entry for PSMB2 Gene

Proteomics data for PSMB2 Gene at MOPED

Selected DME Specific Peptides for PSMB2 Gene

Post-translational modifications for PSMB2 Gene

  • Ubiquitination at Lys 29, Lys 34, Lys 62, Lys 68, Lys 162, Lys 169, Lys 185, and Lys 198
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB2 Gene

Domains & Families for PSMB2 Gene

Gene Families for PSMB2 Gene

Protein Domains for PSMB2 Gene

Suggested Antigen Peptide Sequences for PSMB2 Gene

Graphical View of Domain Structure for InterPro Entry

P49721

UniProtKB/Swiss-Prot:

PSB2_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB2: view

Function for PSMB2 Gene

Molecular function for PSMB2 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20s),proteasome (prosome,macropain) component,beta 2 (HSC7-1),22.8kDa
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit has a trypsin-like activity.
UniProtKB/Swiss-Prot Induction:
Up-regulated in ovarian cancer cell lines.

Enzyme Numbers (IUBMB) for PSMB2 Gene

genes like me logo Genes that share phenotypes with PSMB2: view

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMB2 Gene

Localization for PSMB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMB2 Gene COMPARTMENTS Subcellular localization image for PSMB2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PSMB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PSMB2: view

Pathways & Interactions for PSMB2 Gene

SuperPathways for PSMB2 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin-3, 5 and GM-CSF signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.48
5 Immune System
genes like me logo Genes that share pathways with PSMB2: view

Gene Ontology (GO) - Biological Process for PSMB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSMB2: view

No data available for SIGNOR curated interactions for PSMB2 Gene

Drugs & Compounds for PSMB2 Gene

(7) Drugs for PSMB2 Gene - From: DrugBank, DGIdb, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other, Target, antagonist Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 776
carfilzomib Approved Pharma other, Inhibitor, Target Other, 20S Proteasome Inhibitor 0
Kyprolis Approved July 2012 Pharma 0
Velcade Approved May 2003 Pharma 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMB2: view

Transcripts for PSMB2 Gene

Unigene Clusters for PSMB2 Gene

Proteasome (prosome, macropain) subunit, beta type, 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - - -
SP2: -
SP3: - -
SP4:
SP5: - -
SP6: -

Relevant External Links for PSMB2 Gene

GeneLoc Exon Structure for
PSMB2
ECgene alternative splicing isoforms for
PSMB2

Expression for PSMB2 Gene

mRNA expression in normal human tissues for PSMB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMB2 Gene

This gene is overexpressed in Nasal epithelium (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMB2 Gene



SOURCE GeneReport for Unigene cluster for PSMB2 Gene Hs.471441

genes like me logo Genes that share expression patterns with PSMB2: view

Protein tissue co-expression partners for PSMB2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMB2 Gene

Orthologs for PSMB2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMB2 35
  • 93.2 (n)
  • 98.51 (a)
PSMB2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMB2 35
  • 93.86 (n)
  • 99 (a)
PSMB2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmb2 35
  • 91.87 (n)
  • 96.52 (a)
Psmb2 16
Psmb2 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSMB2 35
  • 99.67 (n)
  • 100 (a)
PSMB2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmb2 35
  • 90.71 (n)
  • 96.02 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PSMB2 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMB2 35
  • 80.47 (n)
  • 87.37 (a)
PSMB2 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMB2 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb2 35
  • 73.91 (n)
  • 82.83 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.7341 35
psmb2 35
  • 73.37 (n)
  • 81.91 (a)
psmb2 36
  • 82 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8242 35
fruit fly
(Drosophila melanogaster)
Insecta CG17331 37
  • 51 (a)
CG17331 35
  • 57.09 (n)
  • 51.28 (a)
CG17331 36
  • 50 (a)
OneToMany
Prosbeta4R1 36
  • 31 (a)
OneToMany
Prosbeta4R2 36
  • 41 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008837 35
  • 60 (n)
  • 56.92 (a)
worm
(Caenorhabditis elegans)
Secernentea pbs-4 35
  • 47.96 (n)
  • 37.24 (a)
pbs-4 36
  • 37 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR019W 35
  • 50.78 (n)
  • 44.04 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B11660g 35
  • 53.02 (n)
  • 45.08 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE1 35
  • 51.99 (n)
  • 45.08 (a)
PRE1 36
  • 44 (a)
OneToOne
PRE1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PBD1 35
  • 53.09 (n)
  • 46.03 (a)
rice
(Oryza sativa)
Liliopsida Os03g0695600 35
  • 52.56 (n)
  • 44.97 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01368 35
  • 49.47 (n)
  • 47.34 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC31A2.04c 35
  • 50.35 (n)
  • 45.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2848 36
  • 55 (a)
OneToOne
Species with no ortholog for PSMB2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMB2 Gene

ENSEMBL:
Gene Tree for PSMB2 (if available)
TreeFam:
Gene Tree for PSMB2 (if available)

Paralogs for PSMB2 Gene

No data available for Paralogs for PSMB2 Gene

Variants for PSMB2 Gene

Sequence variations from dbSNP and Humsavar for PSMB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12386 -- 35,603,262(-) ACATC(A/G)TGTCC utr-variant-3-prime
rs535431 -- 35,642,838(-) ttttt(A/T)ttttt upstream-variant-2KB
rs535434 -- 35,642,837(-) tttta(A/T)ttttt upstream-variant-2KB
rs545929 -- 35,622,835(-) ttttc(A/T)ttttc intron-variant
rs506288 -- 35,643,709(-) ACCTC(C/T)GTCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PSMB2 Gene

Variant ID Type Subtype PubMed ID
nsv433 CNV Loss 18451855
esv2746763 CNV Deletion 23290073
esv2662513 CNV Deletion 23128226
esv2746774 CNV Deletion 23290073

Variation tolerance for PSMB2 Gene

Residual Variation Intolerance Score: 51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PSMB2 Gene

Disorders for PSMB2 Gene

Relevant External Links for PSMB2

Genetic Association Database (GAD)
PSMB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMB2

No disorders were found for PSMB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMB2 Gene

Publications for PSMB2 Gene

  1. Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues. (PMID: 7918633) Nothwang H.G. … Ichihara A. (Biochim. Biophys. Acta 1994) 2 3 4 67
  2. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for PSMB2 Gene

Sources for PSMB2 Gene

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