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Aliases for PSMB11 Gene

Aliases for PSMB11 Gene

  • Proteasome Subunit Beta 11 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 11 2 3
  • Proteasome Subunit Beta-5t 3 4
  • EC 3.4.25.1 4 61
  • Proteasome Subunit Beta Type-11 3
  • Proteasome Subunit Beta 5T 3
  • BETA5T 3

External Ids for PSMB11 Gene

Previous GeneCards Identifiers for PSMB11 Gene

  • GC14P022583
  • GC14P023511
  • GC14P003628
  • GC14P023393
  • GC14P023558
  • GC14P023669
  • GC14P023795
  • GC14P023883

Summaries for PSMB11 Gene

Entrez Gene Summary for PSMB11 Gene

  • Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PSMB11 Gene

PSMB11 (Proteasome Subunit Beta 11) is a Protein Coding gene. Diseases associated with PSMB11 include Thymus Cancer. Among its related pathways are RET signaling and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB8.

UniProtKB/Swiss-Prot for PSMB11 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB11 Gene

Genomics for PSMB11 Gene

Regulatory Elements for PSMB11 Gene

Enhancers for PSMB11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G022976 1.9 FANTOM5 ENCODE dbSUPER 11.1 -62.3 -62262 7.6 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 PRMT5 HAUS4 LOC102724814 MMP14 PSMB5 C14orf119 CDH24 C14orf93 PSMB11 PABPN1
GH14G023067 1.6 Ensembl ENCODE dbSUPER 12.3 +28.3 28296 5.9 HDGF PKNOX1 MLX ARNT ZFP64 WRNIP1 SIN3A ARID4B DMAP1 YBX1 PSMB11 PSMB5 C14orf119 ACIN1 C14orf93 CEBPE AJUBA HAUS4 SLC7A8 RNF212B
GH14G022994 1.3 Ensembl ENCODE dbSUPER 12 -47.3 -47300 1.1 ELF3 CTCF SAP130 TEAD4 ARID4B ZIC2 ZNF48 RAD21 TEAD3 ZFHX2 PRMT5 CDH24 PSMB5 PSMB11 ACIN1 GC14P023988 ENSG00000280129
GH14G023060 1.2 ENCODE dbSUPER 12.3 +20.6 20604 4.3 PKNOX1 SIN3A ZNF2 YY1 GLIS2 GATA2 FOS PAF1 TSHZ1 SMARCA4 EFS PSMB11 PSMB5 ACIN1 C14orf93 C14orf119 AJUBA HAUS4 RNF212B SLC7A8
GH14G022996 1.2 FANTOM5 dbSUPER 11.9 -45.2 -45159 0.2 PKNOX1 ZSCAN4 ZNF155 EGR1 ZNF366 SCRT2 ZNF548 ZNF391 EGR2 OVOL3 CDH24 PABPN1 ACIN1 PSMB5 PSMB11 PRMT5 BCL2L2 C14orf119 CEBPE GC14P023988
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSMB11 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSMB11 Gene

Chromosome:
14
Start:
23,042,167 bp from pter
End:
23,044,276 bp from pter
Size:
2,110 bases
Orientation:
Plus strand

Genomic View for PSMB11 Gene

Genes around PSMB11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB11 Gene

Proteins for PSMB11 Gene

  • Protein details for PSMB11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5LHX3-PSB11_HUMAN
    Recommended name:
    Proteasome subunit beta type-11
    Protein Accession:
    A5LHX3

    Protein attributes for PSMB11 Gene

    Size:
    300 amino acids
    Molecular mass:
    32530 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Incorporated instead of PSMB5 and PSMB8.

neXtProt entry for PSMB11 Gene

Selected DME Specific Peptides for PSMB11 Gene

A5LHX3:
  • GSGSPYA
  • HGTTTLAF
  • RDAYSGG

Post-translational modifications for PSMB11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PSMB11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PSMB11 Gene

Suggested Antigen Peptide Sequences for PSMB11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A5LHX3

UniProtKB/Swiss-Prot:

PSB11_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB11: view

No data available for Gene Families for PSMB11 Gene

Function for PSMB11 Gene

Molecular function for PSMB11 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity).

Enzyme Numbers (IUBMB) for PSMB11 Gene

Gene Ontology (GO) - Molecular Function for PSMB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IDA,IEA 17540904
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMB11: view
genes like me logo Genes that share phenotypes with PSMB11: view

Animal Models for PSMB11 Gene

MGI Knock Outs for PSMB11:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMB11 Gene

Localization for PSMB11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMB11 gene
Compartment Confidence
cytosol 5
nucleus 4
extracellular 1

Gene Ontology (GO) - Cellular Components for PSMB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005839 proteasome core complex IEA --
genes like me logo Genes that share ontologies with PSMB11: view

Pathways & Interactions for PSMB11 Gene

SuperPathways for PSMB11 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 HIV Life Cycle
.45
4 Class I MHC mediated antigen processing and presentation
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with PSMB11: view

Gene Ontology (GO) - Biological Process for PSMB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IEA,IDA 17540904
genes like me logo Genes that share ontologies with PSMB11: view

No data available for SIGNOR curated interactions for PSMB11 Gene

Drugs & Compounds for PSMB11 Gene

(3) Drugs for PSMB11 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AM 114 Pharma 20S proteasome inhibitor 0
CEP-18770 Pharma Proteasome inhibitor 0
MLN9708 Pharma Proteasome inhibitor, 20S Proteasome Inhibitor 0

(3) ApexBio Compounds for PSMB11 Gene

Compound Action Cas Number
AM 114 20S proteasome inhibitor 856849-35-9
CEP-18770 Proteasome inhibitor 847499-27-8
MLN9708 Proteasome inhibitor 1201902-80-8
genes like me logo Genes that share compounds with PSMB11: view

Transcripts for PSMB11 Gene

mRNA/cDNA for PSMB11 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PSMB11 Gene

Proteasome (prosome, macropain) subunit, beta type, 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB11 Gene

No ASD Table

Relevant External Links for PSMB11 Gene

GeneLoc Exon Structure for
PSMB11
ECgene alternative splicing isoforms for
PSMB11

Expression for PSMB11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMB11 Gene

mRNA differential expression in normal tissues according to GTEx for PSMB11 Gene

This gene is overexpressed in Testis (x26.2).

Protein differential expression in normal tissues from HIPED for PSMB11 Gene

This gene is overexpressed in Retina (57.6) and NK cells (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PSMB11 Gene



Protein tissue co-expression partners for PSMB11 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSMB11 Gene:

PSMB11

SOURCE GeneReport for Unigene cluster for PSMB11 Gene:

Hs.508918
genes like me logo Genes that share expression patterns with PSMB11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMB11 Gene

Orthologs for PSMB11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PSMB11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMB11 34 35
  • 99.67 (n)
cow
(Bos Taurus)
Mammalia PSMB11 34 35
  • 84.68 (n)
dog
(Canis familiaris)
Mammalia PSMB11 34 35
  • 84.04 (n)
rat
(Rattus norvegicus)
Mammalia Psmb11 34
  • 83.28 (n)
mouse
(Mus musculus)
Mammalia Psmb11 34 16 35
  • 82.11 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMB11 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMB11 35
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMB11 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb11 34
  • 52.73 (n)
zebrafish
(Danio rerio)
Actinopterygii psmb11b 34
  • 59.15 (n)
PSMB11 (1 of 2) 35
  • 55 (a)
OneToMany
SI:CH211-14A17.13 35
  • 33 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Prosbeta5 35
  • 38 (a)
ManyToMany
CG31742 35
  • 34 (a)
ManyToMany
Prosbeta5R 35
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea pbs-5 35
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE2 35
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8465 35
  • 42 (a)
OneToMany
Species where no ortholog for PSMB11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMB11 Gene

ENSEMBL:
Gene Tree for PSMB11 (if available)
TreeFam:
Gene Tree for PSMB11 (if available)

Paralogs for PSMB11 Gene

Paralogs for PSMB11 Gene

(3) SIMAP similar genes for PSMB11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PSMB11: view

Variants for PSMB11 Gene

Sequence variations from dbSNP and Humsavar for PSMB11 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000042249 -- 23,044,185(+) TCTCC(G/T)GCCCC downstream-variant-500B
rs1001760648 -- 23,041,779(+) TCTAC(A/G)TGCCC upstream-variant-2KB
rs1002822903 -- 23,042,740(+) GCAGG(C/G)GGACA reference, missense
rs1003719609 -- 23,043,584(+) AGCAG(C/G)CCCTC utr-variant-3-prime
rs1003771963 -- 23,043,799(+) ACAGT(A/G)AGTGG utr-variant-3-prime

Variation tolerance for PSMB11 Gene

Residual Variation Intolerance Score: 86.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMB11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMB11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PSMB11 Gene

Disorders for PSMB11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSMB11 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
thymus cancer
  • neoplasm of thymus
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PSMB11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMB11
genes like me logo Genes that share disorders with PSMB11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMB11 Gene

Publications for PSMB11 Gene

  1. Regulation of CD8+ T cell development by thymus-specific proteasomes. (PMID: 17540904) Murata S. … Tanaka K. (Science 2007) 2 3 4 64
  2. Decreased expression of thymus-specific proteasome subunit I^5t in Down syndrome patients. (PMID: 25556590) Tomaru U. … Kasahara M. (Histopathology 2015) 3 64
  3. Expression of thymoproteasome subunit I^5t in type AB thymoma. (PMID: 24293611) Yamada Y. … Matsuno Y. (J. Clin. Pathol. 2013) 3 64
  4. Impaired bortezomib binding to mutant I^5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells. (PMID: 21941364) Franke N.E. … Cloos J. (Leukemia 2012) 3 64
  5. Expression of proteasome subunit I^5t in thymic epithelial tumors. (PMID: 21836487) Yamada Y. … Kasahara M. (Am. J. Surg. Pathol. 2011) 3 64

Products for PSMB11 Gene

Sources for PSMB11 Gene

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