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Aliases for PSMB11 Gene

Aliases for PSMB11 Gene

  • Proteasome Subunit Beta 11 2 3
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 11 2 3 5
  • Proteasome Subunit Beta-5t 3 4
  • EC 3.4.25.1 4 63
  • Proteasome Subunit Beta 5T 3
  • BETA5T 3

External Ids for PSMB11 Gene

Previous GeneCards Identifiers for PSMB11 Gene

  • GC14P022583
  • GC14P023511
  • GC14P003628
  • GC14P023393
  • GC14P023558

Summaries for PSMB11 Gene

Entrez Gene Summary for PSMB11 Gene

  • Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PSMB11 Gene

PSMB11 (Proteasome Subunit Beta 11) is a Protein Coding gene. Diseases associated with PSMB11 include thymus cancer and thymoma. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB5.

UniProtKB/Swiss-Prot for PSMB11 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB11 Gene

Genomics for PSMB11 Gene

Regulatory Elements for PSMB11 Gene

Genomic Location for PSMB11 Gene

Chromosome:
14
Start:
23,042,167 bp from pter
End:
23,044,276 bp from pter
Size:
2,110 bases
Orientation:
Plus strand

Genomic View for PSMB11 Gene

Genes around PSMB11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB11 Gene

Proteins for PSMB11 Gene

  • Protein details for PSMB11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5LHX3-PSB11_HUMAN
    Recommended name:
    Proteasome subunit beta type-11
    Protein Accession:
    A5LHX3

    Protein attributes for PSMB11 Gene

    Size:
    300 amino acids
    Molecular mass:
    32530 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Incorporated instead of PSMB5 and PSMB8.

neXtProt entry for PSMB11 Gene

Proteomics data for PSMB11 Gene at MOPED

Selected DME Specific Peptides for PSMB11 Gene

Post-translational modifications for PSMB11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PSMB11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PSMB11 Gene

Protein Domains for PSMB11 Gene

Suggested Antigen Peptide Sequences for PSMB11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A5LHX3

UniProtKB/Swiss-Prot:

PSB11_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB11: view

No data available for Gene Families for PSMB11 Gene

Function for PSMB11 Gene

Molecular function for PSMB11 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity).

Enzyme Numbers (IUBMB) for PSMB11 Gene

genes like me logo Genes that share phenotypes with PSMB11: view

Animal Models for PSMB11 Gene

MGI Knock Outs for PSMB11:

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMB11 Gene

Localization for PSMB11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMB11 Gene COMPARTMENTS Subcellular localization image for PSMB11 gene
Compartment Confidence
cytosol 5
nucleus 4
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for PSMB11 Gene

Pathways & Interactions for PSMB11 Gene

SuperPathways for PSMB11 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin-3, 5 and GM-CSF signaling
3 Infectious disease
.48
4 Immune System
5 Cell Cycle, Mitotic
.61
genes like me logo Genes that share pathways with PSMB11: view

Pathways by source for PSMB11 Gene

1 KEGG pathway for PSMB11 Gene

Gene Ontology (GO) - Biological Process for PSMB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with PSMB11: view

No data available for SIGNOR curated interactions for PSMB11 Gene

Drugs & Compounds for PSMB11 Gene

(3) Drugs for PSMB11 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AM 114 Pharma 20S proteasome inhibitor 0
CEP-18770 Pharma Proteasome inhibitor 0
MLN9708 Pharma Proteasome inhibitor, 20S Proteasome Inhibitor 0

(3) ApexBio Compounds for PSMB11 Gene

Compound Action Cas Number
AM 114 20S proteasome inhibitor 856849-35-9
CEP-18770 Proteasome inhibitor 847499-27-8
MLN9708 Proteasome inhibitor 1201902-80-8
genes like me logo Genes that share compounds with PSMB11: view

Transcripts for PSMB11 Gene

mRNA/cDNA for PSMB11 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PSMB11 Gene

Proteasome (prosome, macropain) subunit, beta type, 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB11 Gene

No ASD Table

Relevant External Links for PSMB11 Gene

GeneLoc Exon Structure for
PSMB11
ECgene alternative splicing isoforms for
PSMB11

Expression for PSMB11 Gene

mRNA expression in normal human tissues for PSMB11 Gene

mRNA differential expression in normal tissues according to GTEx for PSMB11 Gene

This gene is overexpressed in Testis (x26.2).

Protein differential expression in normal tissues from HIPED for PSMB11 Gene

This gene is overexpressed in Retina (57.6) and NK cells (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PSMB11 Gene



SOURCE GeneReport for Unigene cluster for PSMB11 Gene Hs.508918

genes like me logo Genes that share expression patterns with PSMB11: view

Protein tissue co-expression partners for PSMB11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PSMB11 Gene

Orthologs for PSMB11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PSMB11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMB11 35
  • 84.68 (n)
  • 85.96 (a)
PSMB11 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMB11 35
  • 84.04 (n)
  • 85.46 (a)
PSMB11 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmb11 35
  • 82.11 (n)
  • 84 (a)
Psmb11 16
Psmb11 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSMB11 35
  • 99.67 (n)
  • 99.33 (a)
PSMB11 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmb11 35
  • 83.28 (n)
  • 82.94 (a)
oppossum
(Monodelphis domestica)
Mammalia PSMB11 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMB11 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMB11 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb11 35
  • 52.73 (n)
  • 54.51 (a)
zebrafish
(Danio rerio)
Actinopterygii psmb11b 35
  • 59.15 (n)
  • 63.59 (a)
PSMB11 (1 of 2) 36
  • 55 (a)
OneToMany
SI:CH211-14A17.13 36
  • 33 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG31742 36
  • 34 (a)
ManyToMany
Prosbeta5 36
  • 38 (a)
ManyToMany
Prosbeta5R 36
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea pbs-5 36
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE2 36
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8465 36
  • 42 (a)
OneToMany
Species with no ortholog for PSMB11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMB11 Gene

ENSEMBL:
Gene Tree for PSMB11 (if available)
TreeFam:
Gene Tree for PSMB11 (if available)

Paralogs for PSMB11 Gene

Paralogs for PSMB11 Gene

(3) SIMAP similar genes for PSMB11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PSMB11: view

Variants for PSMB11 Gene

Sequence variations from dbSNP and Humsavar for PSMB11 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs34457782 - 23,042,370(+) CCCAC(A/G)GCACC reference, missense
rs4981456 -- 23,042,148(+) TCTCT(C/G)TAGCG upstream-variant-2KB
rs7160894 -- 23,040,755(+) attct(C/T)gtgcc upstream-variant-2KB
rs8008598 -- 23,041,518(+) cttgg(C/T)ctctc upstream-variant-2KB
rs11621374 -- 23,040,377(+) AAGGG(A/G)GAGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PSMB11 Gene

Variant ID Type Subtype PubMed ID
nsv901491 CNV Loss 21882294

Variation tolerance for PSMB11 Gene

Residual Variation Intolerance Score: 86.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMB11 Gene

HapMap Linkage Disequilibrium report
PSMB11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMB11 Gene

Disorders for PSMB11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PSMB11 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
thymus cancer
  • neoplasm of thymus
thymoma
  • primary thymic epithelial neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PSMB11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMB11
genes like me logo Genes that share disorders with PSMB11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMB11 Gene

Publications for PSMB11 Gene

  1. Regulation of CD8+ T cell development by thymus-specific proteasomes. (PMID: 17540904) Murata S. … Tanaka K. (Science 2007) 2 3 4 67
  2. Expression of thymoproteasome subunit I^5t in type AB thymoma. (PMID: 24293611) Yamada Y. … Matsuno Y. (J. Clin. Pathol. 2013) 3
  3. Impaired bortezomib binding to mutant I^5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells. (PMID: 21941364) Franke N.E. … Cloos J. (Leukemia 2012) 3
  4. Expression of proteasome subunit I^5t in thymic epithelial tumors. (PMID: 21836487) Yamada Y. … Kasahara M. (Am. J. Surg. Pathol. 2011) 3
  5. Exclusive expression of proteasome subunit {beta}5t in the human thymic cortex. (PMID: 19289856) Tomaru U. … Kasahara M. (Blood 2009) 3

Products for PSMB11 Gene

Sources for PSMB11 Gene

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