Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PSMB10 Gene

Aliases for PSMB10 Gene

  • Proteasome Subunit Beta 10 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 10 2 3
  • Multicatalytic Endopeptidase Complex Subunit MECl-1 3 4
  • Low Molecular Mass Protein 10 3 4
  • Proteasome Subunit Beta-2i 3 4
  • Macropain Subunit MECl-1 3 4
  • Proteasome MECl-1 3 4
  • EC 3.4.25.1 4 61
  • MECL1 3 4
  • LMP10 3 4
  • Proteasome Catalytic Subunit 2i 3
  • Proteasome Subunit Beta Type-10 3
  • Proteasome Subunit Beta 7i 3
  • Proteasome Subunit MECL1 3
  • Beta2i 3

External Ids for PSMB10 Gene

Previous HGNC Symbols for PSMB10 Gene

  • MECL1

Previous GeneCards Identifiers for PSMB10 Gene

  • GC16M058663
  • GC16M068342
  • GC16M067699
  • GC16M067739
  • GC16M066520
  • GC16M066525
  • GC16M067968
  • GC16M053841

Summaries for PSMB10 Gene

Entrez Gene Summary for PSMB10 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMB10 Gene

PSMB10 (Proteasome Subunit Beta 10) is a Protein Coding gene. Among its related pathways are RET signaling and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB7.

UniProtKB/Swiss-Prot for PSMB10 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.

Gene Wiki entry for PSMB10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB10 Gene

Genomics for PSMB10 Gene

Regulatory Elements for PSMB10 Gene

Enhancers for PSMB10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F068004 1.1 FANTOM5 Ensembl ENCODE 11.6 -69.1 -69114 4.0 HDGF PKNOX1 ATF1 ARID4B ZNF121 ZNF143 DEK REST SSRP1 MYNN DPEP2 NFATC3 DUS2 DPEP3 PSMB10 PRMT7 ACD PARD6A LCAT DDX28
GH16F067992 1.3 FANTOM5 ENCODE 6.4 -57.8 -57792 4.1 HDGF PKNOX1 CREB3L1 SIN3A ARID4B DMAP1 ZNF2 ZNF143 ZNF207 ZNF263 PRMT7 ACD DDX28 ZDHHC1 KIAA0895L RNU6-359P SLC12A4 LCAT DPEP2 DUS2
GH16F067527 0.7 FANTOM5 ENCODE 5.7 +407.0 407021 4.4 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 FOS CENPT C16orf70 KIAA0895L ACD ATP6V0D1 ZDHHC1 ENKD1 ENSG00000261386 ENSG00000259804 PSMB10
GH16F068279 1.7 FANTOM5 Ensembl ENCODE 5.3 -349.4 -349374 13.5 HDGF PKNOX1 MLX WRNIP1 ARID4B DMAP1 SLC30A9 FOS SP5 JUNB PRMT7 SLC7A6 NFATC3 DPEP2 SLC7A6OS RNU4-30P DUS2 RANBP10 PSMB10 LRRC36
GH16F067276 0.5 ENCODE 5.1 +658.7 658743 3.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS ZNF263 ENSG00000260465 RANBP10 E2F4 CENPT LRRC36 ENSG00000263276 ENSG00000270165 TSNAXIP1 PSMB10 ATP6V0D1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PSMB10 on UCSC Golden Path with GeneCards custom track

Promoters for PSMB10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052918 987 2201 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1

Genomic Location for PSMB10 Gene

Chromosome:
16
Start:
67,934,502 bp from pter
End:
67,937,087 bp from pter
Size:
2,586 bases
Orientation:
Minus strand

Genomic View for PSMB10 Gene

Genes around PSMB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB10 Gene

Proteins for PSMB10 Gene

  • Protein details for PSMB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40306-PSB10_HUMAN
    Recommended name:
    Proteasome subunit beta type-10
    Protein Accession:
    P40306
    Secondary Accessions:
    • B2R5J4
    • Q5U098

    Protein attributes for PSMB10 Gene

    Size:
    273 amino acids
    Molecular mass:
    28936 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent houskeeping subunit PSMB7. Component of the spermatoproteasome, a form of the proteasome specifically found in testis. Interacts with HIV-1 TAT protein.

neXtProt entry for PSMB10 Gene

Selected DME Specific Peptides for PSMB10 Gene

P40306:
  • LGADTRAT
  • IYCCGAG

Post-translational modifications for PSMB10 Gene

  • Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.
  • Ubiquitination at Lys 31, Lys 37, Lys 68, Lys 72, Lys 79, Lys 101, and Lys 236
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PSMB10 (PSMB10/MECL1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for PSMB10

Domains & Families for PSMB10 Gene

Gene Families for PSMB10 Gene

Suggested Antigen Peptide Sequences for PSMB10 Gene

Graphical View of Domain Structure for InterPro Entry

P40306

UniProtKB/Swiss-Prot:

PSB10_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB10: view

Function for PSMB10 Gene

Molecular function for PSMB10 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta-type subunit MECL-1,29kDa,interferon gamma inducible
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IFNG/IFN-gamma (at protein level). Up-regulated by IRF1. Up-regulated by TNF (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohns bowel disease (CD). Up-regulated by CD40L via the NFKB1 pathway in cancer cells.

Enzyme Numbers (IUBMB) for PSMB10 Gene

Gene Ontology (GO) - Molecular Function for PSMB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 21516116
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMB10: view
genes like me logo Genes that share phenotypes with PSMB10: view

Animal Models for PSMB10 Gene

MGI Knock Outs for PSMB10:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PSMB10 Gene

Localization for PSMB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMB10 Gene COMPARTMENTS Subcellular localization image for PSMB10 gene
Compartment Confidence
cytosol 5
nucleus 5
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PSMB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS 9551082
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMB10: view

Pathways & Interactions for PSMB10 Gene

SuperPathways for PSMB10 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
.78
.32
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMB10: view

Gene Ontology (GO) - Biological Process for PSMB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PSMB10: view

No data available for SIGNOR curated interactions for PSMB10 Gene

Drugs & Compounds for PSMB10 Gene

(6) Drugs for PSMB10 Gene - From: DrugBank, ApexBio, DGIdb, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
carfilzomib Approved Pharma other, Inhibitor, Target Other, 20S Proteasome Inhibitor 0
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 794
Kyprolis Approved July 2012 Pharma 0
Celastrol Pharma Antioxidant, anti-inflammatory and immunosuppressive agent, Inhibits TNF-alpha-induced NF-kappaB activation 0
Dihydroeponemycin Pharma Proteasome inhibitor,antitumor reagent,eponemycin ddrivative 0

(3) ApexBio Compounds for PSMB10 Gene

Compound Action Cas Number
Celastrol Antioxidant, anti-inflammatory and immunosuppressive agent 34157-83-0
Dihydroeponemycin Proteasome inhibitor,antitumor reagent,eponemycin ddrivative 126463-64-7
MLN2238 β5 site of the 20S proteasome inhibitor 1072833-77-2
genes like me logo Genes that share compounds with PSMB10: view

Transcripts for PSMB10 Gene

Unigene Clusters for PSMB10 Gene

Proteasome (prosome, macropain) subunit, beta type, 10:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB10 Gene

No ASD Table

Relevant External Links for PSMB10 Gene

GeneLoc Exon Structure for
PSMB10
ECgene alternative splicing isoforms for
PSMB10

Expression for PSMB10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMB10 Gene

mRNA differential expression in normal tissues according to GTEx for PSMB10 Gene

This gene is overexpressed in Whole Blood (x9.6).

Protein differential expression in normal tissues from HIPED for PSMB10 Gene

This gene is overexpressed in Lymph node (12.1), Peripheral blood mononuclear cells (8.2), and Tlymphocyte (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMB10 Gene



Protein tissue co-expression partners for PSMB10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMB10 Gene:

PSMB10

SOURCE GeneReport for Unigene cluster for PSMB10 Gene:

Hs.9661
genes like me logo Genes that share expression patterns with PSMB10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PSMB10 Gene

Orthologs for PSMB10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PSMB10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMB10 34 35
  • 99.39 (n)
cow
(Bos Taurus)
Mammalia PSMB10 34 35
  • 86.94 (n)
dog
(Canis familiaris)
Mammalia PSMB10 34 35
  • 85.1 (n)
mouse
(Mus musculus)
Mammalia Psmb10 34 16 35
  • 83.52 (n)
rat
(Rattus norvegicus)
Mammalia Psmb10 34
  • 82.54 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMB10 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMB10 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489016 34
  • 58.33 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:92791 34
  • 66.67 (n)
PSMB10 35
  • 62 (a)
OneToOne
Dr.15777 34
fruit fly
(Drosophila melanogaster)
Insecta CG18341 36
  • 49 (a)
Prosbeta2 35
  • 48 (a)
ManyToMany
Prosbeta2R1 35
  • 41 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea pbs-2 35
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUP1 35
  • 46 (a)
OneToMany
Species where no ortholog for PSMB10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMB10 Gene

ENSEMBL:
Gene Tree for PSMB10 (if available)
TreeFam:
Gene Tree for PSMB10 (if available)

Paralogs for PSMB10 Gene

Paralogs for PSMB10 Gene

(3) SIMAP similar genes for PSMB10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PSMB10: view

Variants for PSMB10 Gene

Sequence variations from dbSNP and Humsavar for PSMB10 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1079723 -- 67,935,781(-) GAAGG(A/G)GCGGG intron-variant
rs11075663 -- 67,935,887(-) GAAAG(A/C)AGGGC intron-variant
rs111521191 -- 67,934,120(+) CAGTG(G/T)GGCCT downstream-variant-500B
rs112331300 -- 67,934,151(+) TATGA(A/G)CTTTG downstream-variant-500B
rs1127725 -- 67,936,796(-) GTCTG(A/G)CCGAC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PSMB10 Gene

Variant ID Type Subtype PubMed ID
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680

Variation tolerance for PSMB10 Gene

Residual Variation Intolerance Score: 39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMB10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMB10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMB10 Gene

Disorders for PSMB10 Gene

Relevant External Links for PSMB10

Genetic Association Database (GAD)
PSMB10
Human Genome Epidemiology (HuGE) Navigator
PSMB10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMB10

No disorders were found for PSMB10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMB10 Gene

Publications for PSMB10 Gene

  1. CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF- kappaB-mediated de novo synthesis of IRF-1. (PMID: 18694960) Moschonas A. … Eliopoulos A.G. (Mol. Cell. Biol. 2008) 3 4 22 64
  2. Constitutive and interferon-gamma-induced expression of the human proteasome subunit multicatalytic endopeptidase complex-like 1. (PMID: 9551082) Foss G.S. … Prydz H. (Biochim. Biophys. Acta 1998) 3 4 22 64
  3. A tight cluster of five unrelated human genes on chromosome 16q22.1. (PMID: 8268911) Larsen F. … Prydz H. (Hum. Mol. Genet. 1993) 2 3 4 64
  4. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny E.E. … Peter I. (PLoS Genet. 2012) 3 46 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for PSMB10 Gene

Sources for PSMB10 Gene

Content
Loading form....