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Aliases for PSMB10 Gene

Aliases for PSMB10 Gene

  • Proteasome Subunit Beta 10 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 10 2 3
  • Multicatalytic Endopeptidase Complex Subunit MECl-1 3 4
  • Low Molecular Mass Protein 10 3 4
  • Proteasome Subunit Beta-2i 3 4
  • Macropain Subunit MECl-1 3 4
  • Proteasome MECl-1 3 4
  • EC 4 63
  • MECL1 3 4
  • LMP10 3 4
  • Proteasome Catalytic Subunit 2i 3
  • Proteasome Subunit Beta 7i 3
  • Proteasome Subunit MECL1 3
  • Beta2i 3

External Ids for PSMB10 Gene

Previous HGNC Symbols for PSMB10 Gene

  • MECL1

Previous GeneCards Identifiers for PSMB10 Gene

  • GC16M058663
  • GC16M068342
  • GC16M067699
  • GC16M067739
  • GC16M066520
  • GC16M066525
  • GC16M067968
  • GC16M053841

Summaries for PSMB10 Gene

Entrez Gene Summary for PSMB10 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMB10 Gene

PSMB10 (Proteasome Subunit Beta 10) is a Protein Coding gene. Among its related pathways are Cell Cycle Checkpoints and Mitotic Metaphase and Anaphase. GO annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB7.

UniProtKB/Swiss-Prot for PSMB10 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.

Gene Wiki entry for PSMB10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB10 Gene

Genomics for PSMB10 Gene

Regulatory Elements for PSMB10 Gene

Enhancers for PSMB10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSMB10 on UCSC Golden Path with GeneCards custom track

Promoters for PSMB10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSMB10 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSMB10 Gene

67,934,502 bp from pter
67,937,087 bp from pter
2,586 bases
Minus strand

Genomic View for PSMB10 Gene

Genes around PSMB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB10 Gene

Proteins for PSMB10 Gene

  • Protein details for PSMB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proteasome subunit beta type-10
    Protein Accession:
    Secondary Accessions:
    • B2R5J4
    • Q5U098

    Protein attributes for PSMB10 Gene

    273 amino acids
    Molecular mass:
    28936 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent houskeeping subunit PSMB7. Component of the spermatoproteasome, a form of the proteasome specifically found in testis. Interacts with HIV-1 TAT protein.

neXtProt entry for PSMB10 Gene

Proteomics data for PSMB10 Gene at MOPED

Selected DME Specific Peptides for PSMB10 Gene

Post-translational modifications for PSMB10 Gene

  • Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.
  • Ubiquitination at Lys 31, Lys 37, Lys 68, Lys 72, Lys 79, Lys 101, and Lys 236
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PSMB10 (PSMB10/MECL1)

Domains & Families for PSMB10 Gene

Gene Families for PSMB10 Gene

Suggested Antigen Peptide Sequences for PSMB10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase T1B family.
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB10: view

Function for PSMB10 Gene

Molecular function for PSMB10 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta-type subunit MECL-1,29kDa,interferon gamma inducible
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IFNG/IFN-gamma (at protein level). Up-regulated by IRF1. Up-regulated by TNF (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohns bowel disease (CD). Up-regulated by CD40L via the NFKB1 pathway in cancer cells.

Enzyme Numbers (IUBMB) for PSMB10 Gene

genes like me logo Genes that share phenotypes with PSMB10: view

Animal Models for PSMB10 Gene

MGI Knock Outs for PSMB10:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PSMB10 Gene

Localization for PSMB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for PSMB10 Gene COMPARTMENTS Subcellular localization image for PSMB10 gene
Compartment Confidence
cytosol 5
nucleus 5
endoplasmic reticulum 1
lysosome 1

No data available for Gene Ontology (GO) - Cellular Components for PSMB10 Gene

Pathways & Interactions for PSMB10 Gene

SuperPathways for PSMB10 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 Interleukin-3, 5 and GM-CSF signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
5 Immune System
genes like me logo Genes that share pathways with PSMB10: view

Gene Ontology (GO) - Biological Process for PSMB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000902 cell morphogenesis IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with PSMB10: view

No data available for SIGNOR curated interactions for PSMB10 Gene

Drugs & Compounds for PSMB10 Gene

(6) Drugs for PSMB10 Gene - From: DrugBank, ApexBio, DGIdb, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
carfilzomib Approved Pharma other, Inhibitor, Target Other, 20S Proteasome Inhibitor 0
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 776
Kyprolis Approved July 2012 Pharma 0
Celastrol Pharma Antioxidant, anti-inflammatory and immunosuppressive agent 0
Dihydroeponemycin Pharma Proteasome inhibitor,antitumor reagent,eponemycin ddrivative 0

(3) ApexBio Compounds for PSMB10 Gene

Compound Action Cas Number
Celastrol Antioxidant, anti-inflammatory and immunosuppressive agent 34157-83-0
Dihydroeponemycin Proteasome inhibitor,antitumor reagent,eponemycin ddrivative 126463-64-7
MLN2238 β5 site of the 20S proteasome inhibitor 1072833-77-2
genes like me logo Genes that share compounds with PSMB10: view

Transcripts for PSMB10 Gene

Unigene Clusters for PSMB10 Gene

Proteasome (prosome, macropain) subunit, beta type, 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB10 Gene

No ASD Table

Relevant External Links for PSMB10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSMB10 Gene

mRNA expression in normal human tissues for PSMB10 Gene

mRNA differential expression in normal tissues according to GTEx for PSMB10 Gene

This gene is overexpressed in Whole Blood (x9.6).

Protein differential expression in normal tissues from HIPED for PSMB10 Gene

This gene is overexpressed in Lymph node (12.1), Peripheral blood mononuclear cells (8.2), and Tlymphocyte (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMB10 Gene

SOURCE GeneReport for Unigene cluster for PSMB10 Gene Hs.9661

genes like me logo Genes that share expression patterns with PSMB10: view

Protein tissue co-expression partners for PSMB10 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PSMB10 Gene

Orthologs for PSMB10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PSMB10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PSMB10 35
  • 86.94 (n)
  • 86.81 (a)
PSMB10 36
  • 87 (a)
(Canis familiaris)
Mammalia PSMB10 35
  • 85.1 (n)
  • 85.71 (a)
PSMB10 36
  • 85 (a)
(Mus musculus)
Mammalia Psmb10 35
  • 83.52 (n)
  • 88.64 (a)
Psmb10 16
Psmb10 36
  • 89 (a)
(Pan troglodytes)
Mammalia PSMB10 35
  • 99.39 (n)
  • 100 (a)
PSMB10 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Psmb10 35
  • 82.54 (n)
  • 88.28 (a)
(Monodelphis domestica)
Mammalia PSMB10 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia PSMB10 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489016 35
  • 58.33 (n)
  • 61.74 (a)
(Danio rerio)
Actinopterygii Dr.15777 35
zgc:92791 35
  • 66.67 (n)
  • 64.39 (a)
PSMB10 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18341 37
  • 49 (a)
Prosbeta2 36
  • 48 (a)
Prosbeta2R1 36
  • 41 (a)
(Caenorhabditis elegans)
Secernentea pbs-2 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUP1 36
  • 46 (a)
Species with no ortholog for PSMB10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMB10 Gene

Gene Tree for PSMB10 (if available)
Gene Tree for PSMB10 (if available)

Paralogs for PSMB10 Gene

Paralogs for PSMB10 Gene

(3) SIMAP similar genes for PSMB10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PSMB10: view

Variants for PSMB10 Gene

Sequence variations from dbSNP and Humsavar for PSMB10 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs14178 -- 67,935,628(-) TACGG(C/T)GTGCA reference, synonymous-codon
rs20549 -- 67,936,027(-) ACGCG(A/C/T)TATCT reference, synonymous-codon
rs1079723 -- 67,935,781(-) GAAGG(A/G)GCGGG intron-variant
rs1127725 -- 67,936,796(-) GTCTG(A/G)CCGAC utr-variant-5-prime
rs28473611 -- 67,938,830(+) GCCAC(C/T)GCGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PSMB10 Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680

Variation tolerance for PSMB10 Gene

Residual Variation Intolerance Score: 39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PSMB10 Gene

Disorders for PSMB10 Gene

Relevant External Links for PSMB10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PSMB10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMB10 Gene

Publications for PSMB10 Gene

  1. A tight cluster of five unrelated human genes on chromosome 16q22.1. (PMID: 8268911) Larsen F. … Prydz H. (Hum. Mol. Genet. 1993) 2 3 4 67
  2. CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF- kappaB-mediated de novo synthesis of IRF-1. (PMID: 18694960) Moschonas A. … Eliopoulos A.G. (Mol. Cell. Biol. 2008) 3 23
  3. Impaired expression of proteasome subunits and human leukocyte antigens class I in human colon cancer cells. (PMID: 12519221) Miyagi T. … Hayashi N. (J. Gastroenterol. Hepatol. 2003) 3 23
  4. Constitutive and interferon-gamma-induced expression of the human proteasome subunit multicatalytic endopeptidase complex-like 1. (PMID: 9551082) Foss G.S. … Prydz H. (Biochim. Biophys. Acta 1998) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for PSMB10 Gene

Sources for PSMB10 Gene