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PSMB1 Gene

protein-coding   GIFtS: 69
GCID: GC06M170844

Proteasome (Prosome, Macropain) Subunit, Beta Type, 1

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proteasome (Prosome, Macropain) Subunit, Beta Type, 11 2     EC 3.4.25.13 8
Macropain Subunit C52 3     HC52
Multicatalytic Endopeptidase Complex Subunit C52 3     PMSB12
Proteasome Component C52 3     Proteasome Beta 1 Subunit2
Proteasome Gamma Chain2 3     Proteasome Subunit Beta Type-12
PSC52 3     Proteasome Subunit HC52

External Ids:    HGNC: 95371   Entrez Gene: 56892   Ensembl: ENSG000000080187   OMIM: 6020175   UniProtKB: P206183   

Export aliases for PSMB1 gene to outside databases

Previous GC identifers: GC06M170039 GC06M170459 GC06M170700 GC06M170761 GC06M168349


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PSMB1 Gene:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The
core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and
2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high
concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential
function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene
encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit.
This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in
the opposite orientation in both species. (provided by RefSeq, Jul 2008)

GeneCards Summary for PSMB1 Gene:
PSMB1 (proteasome (prosome, macropain) subunit, beta type, 1) is a protein-coding gene. Diseases associated with PSMB1 include visceral leishmaniasis, and leishmaniasis. GO annotations related to this gene include threonine-type endopeptidase activity.

UniProtKB/Swiss-Prot: PSB1_HUMAN, P20618
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
proteasome has an ATP-dependent proteolytic activity

Gene Wiki entry for PSMB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PSMB1 gene promoter:
         E2F-4   E2F-3a   TBP   E2F-5   RelA   CUTL1   E2F-2   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSMB1 promoter sequence
   Search Chromatin IP Primers for PSMB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSMB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

PSMB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMB1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M170844:  view genomic region     (about GC identifiers)

Start:
170,844,204 bp from pter      End:
170,862,429 bp from pter
Size:
18,226 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PSB1_HUMAN, P20618 (See protein sequence)
Recommended Name: Proteasome subunit beta type-1 precursor  
Size: 241 amino acids; 26489 Da
Subunit: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome
core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure.
The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven
beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with
SERPINB2. Interacts with HIV-1 TAT protein
Secondary accessions: B5BU76 Q9BWA8

Explore the universe of human proteins at neXtProt for PSMB1: NX_P20618

Explore proteomics data for PSMB1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys77, Lys94, Lys164, Lys184, Lys204, Lys228
  • Glycosylation2 at Ser58, Ser209
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PSMB1 (P20618) (see all 8)
     FISAAERD  LAIAGEDF  YSFDPVGSY  VASDTRLSEG 


    See PSMB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002784.1  
    ENSEMBL proteins: 
     ENSP00000262193  
    Reactome Protein details: P20618

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PSM: Proteasome (prosome, macropain) subunits

    3 InterPro protein domains:
     IPR001353 Proteasome_sua/b
     IPR016050 Proteasome_bsu_CS
     IPR023333 Proteasome_suB-type

    Graphical View of Domain Structure for InterPro Entry P20618

    ProtoNet protein and cluster: P20618

    1 Blocks protein domain: IPB000243 Proteasome B-type subunit

    UniProtKB/Swiss-Prot: PSB1_HUMAN, P20618
    Similarity: Belongs to the peptidase T1B family


    PSMB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PSB1_HUMAN, P20618
    Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
    peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
    proteasome has an ATP-dependent proteolytic activity
    Catalytic activity: Cleavage of peptide bonds with very broad specificity

         Genatlas biochemistry entry for PSMB1:
    multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta type 1,subunit HC5,26kDa

         Enzyme Number (IUBMB): EC 3.4.25.11 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004298threonine-type endopeptidase activity IEA--
    GO:0005515protein binding IPI14733938
         
    PSMB1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PSMB1:
     Decreased viability of wild-ty  Decreased viability with pacli  G2 arrest  Increased G2M DNA content 

         1 MGI phenotypic allele for Psmb1 (no phenotypes)

    PSMB1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PSMB1
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    hsa-mir-92a-3p (MIRT049066), hsa-mir-10a-5p (MIRT047743), hsa-mir-125b-5p (MIRT046038)

    Block miRNA regulation of human, mouse, rat PSMB1 using miScript Target Protectors
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    GenScript: all cDNA clones in your preferred vector: PSMB1 (NM_002793)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PSB1_HUMAN, P20618: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex TAS8811196
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0005839proteasome core complex ISS--
    GO:0070062extracellular vesicular exosome IDA19056867

    PSMB1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PSMB1 About   (see all 26)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    CDK-mediated phosphorylation and removal of Cdc60.94
    Destabilization of mRNA by AUF1 (hnRNP D0)0.88
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    G1/S DNA Damage Checkpoints0.87
    Ubiquitin-dependent degradation of Cyclin D10.94
    CDT1 association with the CDC6-ORC-origin complex0.87
    Ubiquitin-dependent degradation of Cyclin D0.94
    SCF(Skp2)-mediated degradation of p27/p210.86
    2Chks in Checkpoint Regulation
    Chks in Checkpoint Regulation0.59
    SREBP Proteolysis0.43
    G2-M Phase Transition0.59
    DNA Repair Mechanisms0.32
    Estrogen-mediated S-Phase Entry0.55
    3Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PSMB1 (see all 17)
        CDK5 Pathway
    Estrogen-mediated S-Phase Entry
    G2-M Phase Transition
    DNA Repair Mechanisms
    GSK3 Signaling

    4 GeneGo (Thomson Reuters) Pathways for PSMB1
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Antigen presentation by MHC class I
    Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of wt-CFTR

    1 BioSystems Pathway for PSMB1
        Proteasome Degradation


    Selected Reactome Pathways for PSMB1 (see all 24)
        SCF(Skp2)-mediated degradation of p27/p21
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
    SCF-beta-TrCP mediated degradation of Emi1
    Ubiquitin-dependent degradation of Cyclin D1
    Orc1 removal from chromatin


    1 Kegg Pathway  (Kegg details for PSMB1):
        Proteasome


    PSMB1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PSMB1
    Interactions:

        Search GeneGlobe Interaction Network for PSMB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PSMB1 (P206181, 2, 3 ENSP000002621934) via UniProtKB, MINT, STRING, and/or I2D (see all 243)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMB7Q994361, 2, 3, ENSP000002594574EBI-372273,EBI-603319 MINT-4050722 MINT-6176276 MINT-6176162 MINT-6176080 I2D: score=10 STRING: ENSP00000259457
    PSMB2P497212, 3, ENSP000003623344MINT-4050722 MINT-6176129 MINT-6176182 MINT-6176080 I2D: score=7 STRING: ENSP00000362334
    POMPQ9Y2442, 3, ENSP000003702224MINT-6176172 MINT-6176482 MINT-6176080 I2D: score=3 STRING: ENSP00000370222
    PSMB4P280702, 3, ENSP000002905414MINT-4050722 MINT-6176080 I2D: score=6 STRING: ENSP00000290541
    PSMA7O148182, 3, ENSP000003599104MINT-4050722 MINT-6176080 I2D: score=5 STRING: ENSP00000359910
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--

    PSMB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for PSMB1 (see all 16)     About this table
    CompoundAction CAS #
    Aclacinomycin ASpecific inhibitor of the 20S proteasome chymotrypsin-like activity[57576-44-0]
    AM 114Boronic-chalcone derived proteasome inhibitor with anticancer activity[856849-35-9]
    Bortezomib (PS-341, LDP-3411)Cell-permeable proteasome inhibitor[179324-69-7]
    Carfilzomib (PR-171)Proteasome inhibitor, analog of epoxomicin[868540-17-4]
    CEP-18770Orally active inhibitor of the chymotrypsin-like activity of proteasome[847499-27-8]
    DihydroeponemycinProteasome inhibitor and antitumor reagent[126463-64-7]
    EpoxomicinIrreversible proteasome inhibitor[134381-21-8]
    GliotoxinNon-competitively inhibits chymotrypsin-like activity of 20S proteasome[67-99-2]
    MG-115Reversible proteasome inhibitor--
    MG-132Cell permeable, reversible proteasome inhibitor[133407-82-6]

    Browse Tocris compounds for PSMB1 (PSB1)

    4 DrugBank Compounds for PSMB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Bortezomib-- 179324-69-7targetantagonist20954323 17139284 17016423
    (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE-- --target--10592235
    Carfilzomib -- 868540-17-4targetinhibitor17591945
    N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PSMB1 gene: 
    NM_002793.3  

    Unigene Cluster for PSMB1:

    Proteasome (prosome, macropain) subunit, beta type, 1
    Hs.352768  [show with all ESTs]
    Unigene Representative Sequence: AK125435
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262193(uc003qxq.2 uc011ehe.2) ENST00000462957(uc003qxr.3)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    GenScript: all cDNA clones in your preferred vector: PSMB1 (NM_002793)
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      QuantiTect SYBR Green Assays in human, mouse, rat PSMB1
      QuantiFast Probe-based Assays in human, mouse, rat PSMB1

    Additional mRNA sequence: 

    AB451312.1 AB451442.1 AK058050.1 AK125435.1 AK223193.1 BC000508.2 BC020807.1 BT019720.1 
    D00761.1 

    Selected DOTS entries (see all 28):

    DT.454432  DT.100884860  DT.97862320  DT.100884856  DT.92010853  DT.95369435  DT.95369447  DT.92460556 
    DT.100039485  DT.121348521  DT.92460554  DT.121348470  DT.100726260  DT.100884842  DT.40268868  DT.95369424 
    DT.95369440  DT.100039480  DT.100039486  DT.100039488  DT.100884857  DT.100884858  DT.121348259  DT.121348480 

    Selected AceView cDNA sequences (see all 794):

    BM761075 BM670505 BE890529 CF130195 CA436323 AK125435 CR597967 BM708206 
    BE463977 AI085665 BE378704 BF196464 AA091816 BM980978 BQ447893 AW007801 
    BE294451 BE792438 AW772027 AA505350 CR604337 NM_002793 BQ653115 AA865769 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PSMB1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
    SP1:                                            -           -                           
    SP2:                          -                 -           -                           
    SP3:                                -           -           -                           
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for PSMB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PSMB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGCTGGTGA
    PSMB1 Expression
    About this image


    PSMB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    PSMB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PSMB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.352768
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PSMB1 gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Psmb11 , 5 proteasome (prosome, macropain) subunit, beta type more1, 5 85.29(n)1
    93.7(a)1
      17 (8.95 cM)5
    191701  NM_011185.31  NP_035315.11 
     154757215 
    chicken
    (Gallus gallus)
    Aves PSMB11 proteasome (prosome, macropain) subunit, beta type, more 79.01(n)
    85.53(a)
      421551  NM_001007905.2  NP_001007906.1 
    lizard
    (Anolis carolinensis)
    Reptilia PSMB16
    proteasome (prosome, macropain) subunit, beta type...
    81(a)
    1 ↔ 1
    1(223195010-223209343)
    African clawed frog
    (Xenopus laevis)
    Amphibia psmb1-prov2 proteasome (prosome, macropain) subunit, beta type more 75.7(n)    BC043739.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc51f062 wufc51f06 75.8(n)   325020  CK395346.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pros261 , 3 ATP-dependent proteolysis proteasome
    endopeptidase3
    Proteasome 26kD subunit1
    52(a)3
    57.7(n)1
    52.83(a)1
      3 73B13
    398551  NM_079391.31  NP_524115.11 
    worm
    (Caenorhabditis elegans)
    Secernentea pbs-61 pbs-6 50.25(n)
    45.69(a)
      176161  NM_066405.4  NP_498806.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRE7(YBL041W)4
    PRE71
    Beta 6 subunit of the 20S proteasome4
    PRE71
    54.46(n)1
    49.3(a)1
      2(141247-141972)4
    8522391, 4  NP_009512.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PBF11 PBF1 54.09(n)
    48.58(a)
      825253  NM_001035828.2  NP_001030905.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g05056001 Os09g0505600 53.91(n)
    50.72(a)
      4347507  NM_001070138.1  NP_001063603.1 


    ENSEMBL Gene Tree for PSMB1 (if available)
    TreeFam Gene Tree for PSMB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PSMB1 gene

    PSMB1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PSMB1
    PGOHUM00000239972


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PSMB1 (see all 424)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1928309831,2
    --170843758(+) TTGTAA/TAAAGG 1 -- int10--------
    rs112981421,2
    C--170843768(+) GCCTAT/-TTTTT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs169014521,2
    C,F,H--170843957(+) GCTGCG/ATAAAC 1 -- int17Minor allele frequency- A:0.01NA NS EA 562
    rs1405319241,2
    --170844037(+) AGTGTA/CAGGGA 1 -- int10--------
    rs1478538431,2
    --170844121(+) ATAGAA/GAAGGG 1 -- int10--------
    rs600604921,2
    C,F--170844172(-) CAGGAC/AAGATA 1 -- int11Minor allele frequency- A:0.00--526
    rs600702151,2
    C,F--170844213(-) AACCTG/AAAGTA 1 -- ut312Minor allele frequency- A:0.00NA 646
    rs1414075761,2
    C--170844334(+) AGTTTC/TCTCCC 2 K E mis10--------
    rs103341,2
    C,H--170844381(-) CACTGG/TGGACG 2 G V mis1 ese35Minor allele frequency- T:0.00MN NS EA 598
    rs105411,2,,4
    C--170844411(-) CTTCAA/TTTCTG 2 N I mis1 ese35Minor allele frequency- T:0.42NA EA MN 438

    HapMap Linkage Disequilibrium report for PSMB1 (170844204 - 170862429 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PSMB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830874CNV Loss17160897
    dgv7056n71CNV Gain21882294
    nsv428158CNV Gain18775914
    esv344CNV CNV17122850
    dgv2040e1CNV Complex17122850
    dgv2041e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602017    OMIM disorders: --

    19 diseases for PSMB1:    
    About MalaCards
    visceral leishmaniasis    leishmaniasis    fanconi's anemia    hiv-1
    huntington's disease    type 1 diabetes    parkinson's disease    cystic fibrosis
    tonsillitis    rheumatoid arthritis    arthritis    alzheimer's disease
    hypoxia    melanoma    thyroiditis    malaria
    cerebritis    prostatitis    endotheliitis


    PSMB1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): PSMB1
    Human Genome Epidemiology (HuGE) Navigator: PSMB1 (3 documents)

    Export disorders for PSMB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PSMB1 gene, integrated from 10 sources (see all 107):
    (articles sorted by number of sources associating them with PSMB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PubMed id 2025653)1, 2, 3 Tamura T.... Ichihara A. (Biochim. Biophys. Acta 1991)
    2. Evaluation of IDDM8 susceptibility locus in a Russian simplex family data set. (PubMed id 15848047)1, 4 Chistiakov D.A....Nosikov V.V. (J. Autoimmun. 2005)
    3. Interaction of plasminogen activator inhibitor-2 and proteasome subunit, beta type 1. (PubMed id 14732874)1, 2 Fan J.... Zhu Y.S. (Acta Biochim. Biophys. Sin. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. (PubMed id 14550573)1, 2 Apcher G.S.... Krueger E. (FEBS Lett. 2003)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome). (PubMed id 2306472)1, 2 Lee L.W....Slaughter C.A. (Biochim. Biophys. Acta 1990)
    8. Identification of the hypoxia-inducible factor 2I+ nuclear interactome in melanoma cells reveals master proteins involved in melanoma development. (PubMed id 23275444)1 Steunou A.L....Nieto L. (amp 2013)
    9. Prespecified candidate biomarkers identify follicular lymphoma patients who achieved longer progression-free survival with bortezomib-rituximab versus rituximab. (PubMed id 23549871)1 Coiffier B....Ricci D. (Clin. Cancer Res. 2013)
    10. Gene expression of catalytic proteasome subunits and resistance toward proteasome inhibition of B lymphocytes from patients with primary sjogren syndrome. (PubMed id 23504381)1 Martinez-Gamboa L....Feist E. (J. Rheumatol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5689 HGNC: 9537 AceView: PSMB1 Ensembl:ENSG00000008018 euGenes: HUgn5689
    ECgene: PSMB1 Kegg: 5689 H-InvDB: PSMB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PSMB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PSMB1 gene:
    Search GeneIP for patents involving PSMB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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