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Aliases for PSMB1 Gene

Aliases for PSMB1 Gene

  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 1 2 3
  • Multicatalytic Endopeptidase Complex Subunit C5 3 4
  • Proteasome Component C5 3 4
  • Proteasome Gamma Chain 3 4
  • Macropain Subunit C5 3 4
  • EC 3.4.25.1 4 64
  • PSC5 3 4
  • Proteasome Subunit Beta Type-1 3
  • Proteasome Beta 1 Subunit 3
  • Proteasome Subunit HC5 3
  • PMSB1 3
  • HC5 3

External Ids for PSMB1 Gene

Summaries for PSMB1 Gene

Entrez Gene Summary for PSMB1 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMB1 Gene

PSMB1 (Proteasome (Prosome, Macropain) Subunit, Beta Type, 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Downstream Signaling Events Of B Cell Receptor (BCR). GO annotations related to this gene include threonine-type endopeptidase activity.

UniProtKB/Swiss-Prot for PSMB1 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity

Gene Wiki entry for PSMB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB1 Gene

Genomics for PSMB1 Gene

Genomic Location for PSMB1 Gene

Start:
170,535,116 bp from pter
End:
170,553,341 bp from pter
Size:
18,226 bases
Orientation:
Minus strand

Genomic View for PSMB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSMB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB1 Gene

Regulatory Elements for PSMB1 Gene

Proteins for PSMB1 Gene

  • Protein details for PSMB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20618-PSB1_HUMAN
    Recommended name:
    Proteasome subunit beta type-1
    Protein Accession:
    P20618
    Secondary Accessions:
    • B5BU76
    • Q9BWA8

    Protein attributes for PSMB1 Gene

    Size:
    241 amino acids
    Molecular mass:
    26489 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with SERPINB2. Interacts with HIV-1 TAT protein.

    Three dimensional structures from OCA and Proteopedia for PSMB1 Gene

neXtProt entry for PSMB1 Gene

Proteomics data for PSMB1 Gene at MOPED

Post-translational modifications for PSMB1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys77, Lys94, Lys164, Lys184, Lys204, and Lys228
  • Glycosylation at Ser58 and Ser209

Other Protein References for PSMB1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PSMB1 Gene

Gene Families for PSMB1 Gene

HGNC:
  • PSM :Proteasome (prosome, macropain) subunits

Protein Domains for PSMB1 Gene

UniProtKB/Swiss-Prot:

PSB1_HUMAN
Family:
  • Belongs to the peptidase T1B family.:
    • P20618
genes like me logo Genes that share domains with PSMB1: view

Function for PSMB1 Gene

Molecular function for PSMB1 Gene

GENATLAS Biochemistry: multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta type 1,subunit HC5,26kDa
UniProtKB/Swiss-Prot CatalyticActivity: Cleavage of peptide bonds with very broad specificity
UniProtKB/Swiss-Prot Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity

Enzyme Numbers (IUBMB) for PSMB1 Gene

Gene Ontology (GO) - Molecular Function for PSMB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 14733938
genes like me logo Genes that share ontologies with PSMB1: view
genes like me logo Genes that share phenotypes with PSMB1: view

miRNA for PSMB1 Gene

miRTarBase miRNAs that target PSMB1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PSMB1 Gene

Localization for PSMB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMB1 Gene COMPARTMENTS Subcellular localization image for PSMB1 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PSMB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 17323924
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005839 proteasome core complex ISS --
genes like me logo Genes that share ontologies with PSMB1: view

Pathways for PSMB1 Gene

SuperPathways for PSMB1 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.38
2 Chks in Checkpoint Regulation
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.62
5 Mitotic Metaphase and Anaphase
genes like me logo Genes that share pathways with PSMB1: view

Gene Ontology (GO) - Biological Process for PSMB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSMB1: view

Compounds for PSMB1 Gene

(16) ApexBio Compounds for PSMB1 Gene

Compound Action Cas Number
Aclacinomycin A Specific inhibitor of the 20S proteasome chymotrypsin-like activity [57576-44-0]
AM 114 Boronic-chalcone derived proteasome inhibitor with anticancer activity [856849-35-9]
Bortezomib (PS-341, LDP-3411) Cell-permeable proteasome inhibitor [179324-69-7]
Carfilzomib (PR-171) Proteasome inhibitor, analog of epoxomicin [868540-17-4]
CEP-18770 Orally active inhibitor of the chymotrypsin-like activity of proteasome [847499-27-8]
Dihydroeponemycin Proteasome inhibitor and antitumor reagent [126463-64-7]
Epoxomicin Irreversible proteasome inhibitor [134381-21-8]
Gliotoxin Non-competitively inhibits chymotrypsin-like activity of 20S proteasome [67-99-2]
MG-115 Reversible proteasome inhibitor
MG-132 Proteasome and calpain inhibitor. [133407-82-6]
MG-262 Boronic acid-based, reversible, cell-permeable proteasome inhibitor
MLN2238 Potent reversible and specific beta5 site of the 20S proteasome inhibitor [1072833-77-2]
MLN9708 Inhibits chymotrypsin-like proteasome activity [1201902-80-8]
ONX-0914 (PR-957) Immunoproteasome inhibitor [960374-59-8]
Oprozomib (ONX-0912) Orally bioavailable inhibitor for CT-L activity of 20S proteasome beta5/LMP7 [935888-69-0]
PSI Inhibits chymotrypsin-like proteasome activity [158442-41-2]
genes like me logo Genes that share compounds with PSMB1: view

Transcripts for PSMB1 Gene

mRNA/cDNA for PSMB1 Gene

Unigene Clusters for PSMB1 Gene

Proteasome (prosome, macropain) subunit, beta type, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5:

Relevant External Links for PSMB1 Gene

GeneLoc Exon Structure for
PSMB1
ECgene alternative splicing isoforms for
PSMB1

Expression for PSMB1 Gene

mRNA expression in normal human tissues for PSMB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMB1 Gene

SOURCE GeneReport for Unigene cluster for PSMB1 Gene Hs.352768

genes like me logo Genes that share expressions with PSMB1: view

Orthologs for PSMB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMB1 36
  • 99.59 (n)
  • 100 (a)
PSMB1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSMB1 36
  • 88.93 (n)
  • 93.78 (a)
PSMB1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMB1 36
  • 88.52 (n)
  • 93.78 (a)
PSMB1 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmb1 36
  • 85.29 (n)
  • 93.7 (a)
Psmb1 16
Psmb1 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PSMB1 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMB1 37
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmb1 36
  • 85.57 (n)
  • 92.44 (a)
chicken
(Gallus gallus)
Aves PSMB1 36
  • 79.01 (n)
  • 85.53 (a)
PSMB1 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMB1 37
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia psmb1-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75736 36
psmb1 36
  • 75.23 (n)
  • 84.4 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8243 36
zebrafish
(Danio rerio)
Actinopterygii psmb1 36
  • 71.7 (n)
  • 81.9 (a)
psmb1 37
  • 81 (a)
OneToOne
wufc51f06 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004991 36
  • 57.56 (n)
  • 52.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pros26 36
  • 57.7 (n)
  • 52.83 (a)
Pros26 37
  • 49 (a)
OneToOne
Pros26 38
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea pbs-6 36
  • 50.25 (n)
  • 45.69 (a)
pbs-6 37
  • 37 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL324W 36
  • 54.98 (n)
  • 50.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE7 36
  • 54.46 (n)
  • 49.3 (a)
PRE7 37
  • 44 (a)
OneToOne
PRE7 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05633g 36
  • 54.07 (n)
  • 48.39 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PBF1 36
  • 54.09 (n)
  • 48.58 (a)
rice
(Oryza sativa)
Liliopsida Os09g0505600 36
  • 53.91 (n)
  • 50.72 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09366 36
  • 52.01 (n)
  • 49.79 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pam1 36
  • 52.25 (n)
  • 47.91 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4908 36
Species with no ortholog for PSMB1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMB1 Gene

ENSEMBL:
Gene Tree for PSMB1 (if available)
TreeFam:
Gene Tree for PSMB1 (if available)

Paralogs for PSMB1 Gene

Pseudogenes.org Pseudogenes for PSMB1 Gene

genes like me logo Genes that share paralogs with PSMB1: view

No data available for Paralogs for PSMB1 Gene

Variants for PSMB1 Gene

Sequence variations from dbSNP and Humsavar for PSMB1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs10334 -- 170,535,293(-) CACTG(G/T)GGACG reference, missense
rs10541 - 170,535,323(-) CTTCA(A/T)TTCTG missense, reference
rs742348 -- 170,536,845(+) caagg(C/G)tcaac intron-variant
rs756517 -- 170,542,264(-) CTTTG(C/T)GTGCG intron-variant
rs756518 -- 170,541,906(-) TCAGC(A/G)GGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMB1 Gene

Variant ID Type Subtype PubMed ID
dgv2040e1 CNV Complex 17122850
esv344 CNV CNV 17122850
nsv428158 CNV Gain 18775914
dgv7056n71 CNV Gain 21882294
dgv2041e1 CNV Complex 17122850
nsv830874 CNV Loss 17160897

Relevant External Links for PSMB1 Gene

HapMap Linkage Disequilibrium report
PSMB1

Disorders for PSMB1 Gene

Relevant External Links for PSMB1

Genetic Association Database (GAD)
PSMB1
Human Genome Epidemiology (HuGE) Navigator
PSMB1
genes like me logo Genes that share disorders with PSMB1: view

No data available for UniProtKB/Swiss-Prot for PSMB1 Gene

Publications for PSMB1 Gene

  1. Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PMID: 2025653) Tamura T. … Ichihara A. (Biochim. Biophys. Acta 1991) 2 3 4
  2. Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome). (PMID: 2306472) Lee L.W. … Slaughter C.A. (Biochim. Biophys. Acta 1990) 3 4
  3. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X. … Huang L. (Biochemistry 2007) 3 4
  4. Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. (PMID: 14550573) Apcher G.S. … Krueger E. (FEBS Lett. 2003) 3 4
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4

Products for PSMB1 Gene

Sources for PSMB1 Gene

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