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Aliases for PSMB1 Gene

Aliases for PSMB1 Gene

  • Proteasome Subunit Beta 1 2 3
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 1 2 3
  • Multicatalytic Endopeptidase Complex Subunit C5 3 4
  • Proteasome Component C5 3 4
  • Proteasome Gamma Chain 3 4
  • Macropain Subunit C5 3 4
  • EC 3.4.25.1 4 63
  • PSC5 3 4
  • Proteasome Beta 1 Subunit 3
  • Proteasome Subunit HC5 3
  • PMSB1 3
  • HC5 3

External Ids for PSMB1 Gene

Previous GeneCards Identifiers for PSMB1 Gene

  • GC06M170039
  • GC06M170459
  • GC06M170700
  • GC06M170761
  • GC06M168349
  • GC06M170844

Summaries for PSMB1 Gene

Entrez Gene Summary for PSMB1 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMB1 Gene

PSMB1 (Proteasome Subunit Beta 1) is a Protein Coding gene. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include threonine-type endopeptidase activity.

UniProtKB/Swiss-Prot for PSMB1 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity

Gene Wiki entry for PSMB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB1 Gene

Genomics for PSMB1 Gene

Regulatory Elements for PSMB1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PSMB1 Gene

Chromosome:
6
Start:
170,535,116 bp from pter
End:
170,553,341 bp from pter
Size:
18,226 bases
Orientation:
Minus strand

Genomic View for PSMB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSMB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB1 Gene

Proteins for PSMB1 Gene

  • Protein details for PSMB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20618-PSB1_HUMAN
    Recommended name:
    Proteasome subunit beta type-1
    Protein Accession:
    P20618
    Secondary Accessions:
    • B5BU76
    • Q9BWA8

    Protein attributes for PSMB1 Gene

    Size:
    241 amino acids
    Molecular mass:
    26489 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with SERPINB2. Interacts with HIV-1 TAT protein.

    Three dimensional structures from OCA and Proteopedia for PSMB1 Gene

neXtProt entry for PSMB1 Gene

Proteomics data for PSMB1 Gene at MOPED

Post-translational modifications for PSMB1 Gene

  • Ubiquitination at Lys 77, Lys 94, Lys 164, Lys 184, Lys 204, and Lys 228
  • Glycosylation at Ser 58 and Ser 209
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PSMB1 Gene

Gene Families for PSMB1 Gene

Protein Domains for PSMB1 Gene

Suggested Antigen Peptide Sequences for PSMB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20618

UniProtKB/Swiss-Prot:

PSB1_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB1: view

Function for PSMB1 Gene

Molecular function for PSMB1 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta type 1,subunit HC5,26kDa
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity

Enzyme Numbers (IUBMB) for PSMB1 Gene

Gene Ontology (GO) - Molecular Function for PSMB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IBA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 14733938
genes like me logo Genes that share ontologies with PSMB1: view
genes like me logo Genes that share phenotypes with PSMB1: view

Animal Model Products

miRNA for PSMB1 Gene

miRTarBase miRNAs that target PSMB1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMB1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PSMB1 Gene

Localization for PSMB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMB1 Gene COMPARTMENTS Subcellular localization image for PSMB1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for PSMB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 17323924
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMB1: view

Pathways & Interactions for PSMB1 Gene

SuperPathways for PSMB1 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin receptor SHC signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.53
5 Immune System
genes like me logo Genes that share pathways with PSMB1: view

Gene Ontology (GO) - Biological Process for PSMB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with PSMB1: view

No data available for SIGNOR curated interactions for PSMB1 Gene

Drugs & Compounds for PSMB1 Gene

(7) Drugs for PSMB1 Gene - From: DrugBank, DGIdb, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other, Target, antagonist Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 758
carfilzomib Approved Pharma other, Inhibitor, Target Other, 20S Proteasome Inhibitor 0
Kyprolis Approved July 2012 Pharma 0
Velcade Approved May 2003 Pharma 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMB1: view

Transcripts for PSMB1 Gene

mRNA/cDNA for PSMB1 Gene

Unigene Clusters for PSMB1 Gene

Proteasome (prosome, macropain) subunit, beta type, 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMB1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5:

Relevant External Links for PSMB1 Gene

GeneLoc Exon Structure for
PSMB1
ECgene alternative splicing isoforms for
PSMB1

Expression for PSMB1 Gene

mRNA expression in normal human tissues for PSMB1 Gene

Protein differential expression in normal tissues from HIPED for PSMB1 Gene

This gene is overexpressed in Liver, secretome (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMB1 Gene



SOURCE GeneReport for Unigene cluster for PSMB1 Gene Hs.352768

genes like me logo Genes that share expression patterns with PSMB1: view

Protein tissue co-expression partners for PSMB1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMB1 Gene

Orthologs for PSMB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMB1 35
  • 88.93 (n)
  • 93.78 (a)
PSMB1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMB1 35
  • 88.52 (n)
  • 93.78 (a)
PSMB1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmb1 35
  • 85.29 (n)
  • 93.7 (a)
Psmb1 16
Psmb1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSMB1 35
  • 99.59 (n)
  • 100 (a)
PSMB1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmb1 35
  • 85.57 (n)
  • 92.44 (a)
oppossum
(Monodelphis domestica)
Mammalia PSMB1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMB1 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMB1 35
  • 79.01 (n)
  • 85.53 (a)
PSMB1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMB1 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75736 35
psmb1 35
  • 75.23 (n)
  • 84.4 (a)
African clawed frog
(Xenopus laevis)
Amphibia psmb1-prov 35
zebrafish
(Danio rerio)
Actinopterygii psmb1 35
  • 71.7 (n)
  • 81.9 (a)
wufc51f06 35
psmb1 36
  • 81 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8243 35
fruit fly
(Drosophila melanogaster)
Insecta Pros26 37
  • 52 (a)
Pros26 35
  • 57.7 (n)
  • 52.83 (a)
Pros26 36
  • 49 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004991 35
  • 57.56 (n)
  • 52.42 (a)
worm
(Caenorhabditis elegans)
Secernentea pbs-6 35
  • 50.25 (n)
  • 45.69 (a)
pbs-6 36
  • 37 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL324W 35
  • 54.98 (n)
  • 50.22 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05633g 35
  • 54.07 (n)
  • 48.39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE7 35
  • 54.46 (n)
  • 49.3 (a)
PRE7 36
  • 44 (a)
OneToOne
PRE7 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PBF1 35
  • 54.09 (n)
  • 48.58 (a)
rice
(Oryza sativa)
Liliopsida Os09g0505600 35
  • 53.91 (n)
  • 50.72 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4908 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09366 35
  • 52.01 (n)
  • 49.79 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pam1 35
  • 52.25 (n)
  • 47.91 (a)
Species with no ortholog for PSMB1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMB1 Gene

ENSEMBL:
Gene Tree for PSMB1 (if available)
TreeFam:
Gene Tree for PSMB1 (if available)

Paralogs for PSMB1 Gene

Pseudogenes.org Pseudogenes for PSMB1 Gene

genes like me logo Genes that share paralogs with PSMB1: view

No data available for Paralogs for PSMB1 Gene

Variants for PSMB1 Gene

Sequence variations from dbSNP and Humsavar for PSMB1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs10334 -- 170,535,293(-) CACTG(G/T)GGACG reference, missense
rs10541 - 170,535,323(-) CTTCA(A/T)TTCTG missense, reference
rs742348 -- 170,536,845(+) caagg(C/G)tcaac intron-variant
rs756518 -- 170,541,906(-) TCAGC(A/G)GGCCA intron-variant
rs756519 -- 170,541,774(-) GATTT(C/T)CATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMB1 Gene

Variant ID Type Subtype PubMed ID
dgv2040e1 CNV Complex 17122850
esv344 CNV CNV 17122850
nsv428158 CNV Gain 18775914
dgv7056n71 CNV Gain 21882294
dgv2041e1 CNV Complex 17122850
nsv830874 CNV Loss 17160897

Variation tolerance for PSMB1 Gene

Residual Variation Intolerance Score: 32.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.82; 83.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMB1 Gene

HapMap Linkage Disequilibrium report
PSMB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMB1 Gene

Disorders for PSMB1 Gene

Relevant External Links for PSMB1

Genetic Association Database (GAD)
PSMB1
Human Genome Epidemiology (HuGE) Navigator
PSMB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMB1
genes like me logo Genes that share disorders with PSMB1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMB1 Gene

Publications for PSMB1 Gene

  1. Fine mapping of genes within the IDDM8 region in rheumatoid arthritis. (PMID: 16945141) Hinks A. … Worthington J. (Arthritis Res. Ther. 2006) 23 67
  2. No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes. (PMID: 15850778) Payne F. … Twells R.C. (Biochem. Biophys. Res. Commun. 2005) 23 67
  3. Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PMID: 2025653) Tamura T. … Ichihara A. (Biochim. Biophys. Acta 1991) 2 67
  4. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for PSMB1 Gene

Sources for PSMB1 Gene

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