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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PSMB1 Gene

protein-coding   GIFtS: 66
GCID: GC06M170844

proteasome (prosome, macropain) subunit, beta type, 1
 Explore 10 diseases affiliated with
PSMB1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PSMB1    

Aliases
for PSMB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Proteasome (Prosome, Macropain) Subunit, Beta Type, 11 2     Proteasome Gamma Chain2 3
HC51 2     PSC52 3
PMSB11 2     EC 3.4.25.13 8
Macropain Subunit C52 3     Proteasome Beta 1 Subunit2
Multicatalytic Endopeptidase Complex Subunit C52 3     Proteasome Subunit Beta Type-12
Proteasome Component C52 3     Proteasome Subunit HC52

External Ids:    HGNC: 95371   Entrez Gene: 56892   Ensembl: ENSG000000080187   OMIM: 6020175   UniProtKB: P206183   

Export aliases for PSMB1 gene to outside databases

Previous GC identifers: GC06M170039 GC06M170459 GC06M170700 GC06M170761 GC06M168349


Summaries
for PSMB1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PSMB1:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core
structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings
are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and
cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified
proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the
proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked
to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both
species. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PSB1_HUMAN, P20618
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
proteasome has an ATP-dependent proteolytic activity

Gene Wiki entry for PSMB1


Genomic Views
for PSMB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PSMB1 gene promoter:
         E2F-4   E2F-3a   TBP   E2F-5   RelA   CUTL1   E2F-2   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PSMB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PSMB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSMB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

PSMB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMB1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M170844:  view genomic region     (about GC identifiers)

Start:
 170,844,204 bp from pter      End:
 170,862,429 bp from pter
Size:
 18,226 bases      Orientation:
 minus strand

Proteins
for PSMB1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PSB1_HUMAN, P20618 (See protein sequence)
Recommended Name: Proteasome subunit beta type-1 precursor  
Size: 241 amino acids; 26489 Da
Subunit: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core
is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two
end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.
The catalytic chamber with the active sites is on the inside of the barrel. Interacts with SERPINB2. Interacts with
HIV-1 TAT protein
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: B5BU76 Q9BWA8

Explore the universe of human proteins at neXtProt for PSMB1: NX_P20618

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P20618

    • 4/8 DME Specific Peptides for PSMB1 (P20618) (see all 8)
     FISAAERD  LAIAGEDF  YSFDPVGSY  VASDTRLSEG 

    PSMB1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002784.1  
    ENSEMBL proteins: 
     ENSP00000262193  
    Reactome Protein details: P20618
    Human Recombinant Protein Products: 
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    Novus Biologicals PSMB1 Lysate
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    ProSpec Recombinant Protein for PSMB1
    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex TAS8811196
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0005839proteasome core complex ISS--


    PSMB1 for ontologies           About GeneDecksing



    PSMB1 Antibody Products: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for PSMB1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PSMB1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001353 Proteasome_sua/b
     IPR016050 Proteasome_bsu_CS
     IPR023333 Proteasome_suB-type

    Graphical View of Domain Structure for InterPro Entry P20618

    ProtoNet protein and cluster: P20618

    1 Blocks protein family: IPB000243 Proteasome B-type subunit

    UniProtKB/Swiss-Prot: PSB1_HUMAN, P20618
    Similarity: Belongs to the peptidase T1B family


    Function
    for PSMB1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PSB1_HUMAN, P20618
    Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
    peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
    proteasome has an ATP-dependent proteolytic activity
    Catalytic activity: Cleavage of peptide bonds with very broad specificity

         Genatlas biochemistry entry for PSMB1:
    multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta type 1,subunit HC5,26kDa

    Enzyme Number (IUBMB): EC 3.4.25.11 2

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
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    OriGene shRNA RFP: PSMB1
    OriGene siRNA: PSMB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSMB1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PSMB1

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMB1 

    Cell Line
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    Search LifeMap BioReagents cell lines for PSMB1

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004298threonine-type endopeptidase activity IEA--
    GO:0005515protein binding IPI--


    PSMB1 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for PSMB1:
     Decreased viability of wild-ty  Decreased viability with pacli  G2 arrest  Increased G2M DNA content 

    Animal Models:
         1 MGI phenotypic allele for Psmb1 (no phenotypes)

    PSMB1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PSMB1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/26 super-pathways (see all 26) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitinated Orc1 is degraded by the proteasome
    8/78 pathways (see all 78)
    		Ubiquitinated Orc1 is degraded by the proteasome1.00
    		Degradation of ubiquitinated p27/p21 by the 26S proteasome0.75
    		Proteasomal cleavage of substrate0.98
    		SCF(Skp2)-mediated degradation of p27/p210.75
    		Proteasome mediated degradation of PAK-2p340.98
    		APC/C:Cdh1-mediated degradation of Skp20.74
    		Proteasomal cleavage of substrate0.98
    		APC/C:Cdc20 mediated degradation of Securin0.74
    2M Phase
    		M Phase1.00
    		Mitotic Anaphase0.85
    		Mitotic M-M/G1 phases0.88
    		Separation of Sister Chromatids0.80
    		Mitotic Metaphase and Anaphase0.85
    3Chks in Checkpoint Regulation
    		Chks in Checkpoint Regulation1.00
    		p53 Signaling0.32
    		G2-M Phase Transition0.59
    		DNA Repair Mechanisms0.32
    		Estrogen-mediated S-Phase Entry0.55
    4HIV Infection
    		HIV Infection1.00
    		Transcription_Ligand-Dependent Transcription of Retinoid-Target genes0.28
    		Host Interactions of HIV factors0.64
    		Transcription Ligand-Dependent Transcription of Retinoid-Target genes0.28
    5Regulation of degradation of wt-CFTR
    		Regulation of degradation of wt-CFTR1.00
    		Regulation of degradation of deltaF508 CFTR in CF0.59

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for PSMB1
        Immune response Antigen presentation by MHC class I
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PSMB1 (see all 17)
        CDK5 Pathway
    Estrogen-mediated S-Phase Entry
    G2-M Phase Transition
    DNA Repair Mechanisms
    GSK3 Signaling

    4 GeneGo (Thomson Reuters) Pathways for PSMB1
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Antigen presentation by MHC class I
    Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of wt-CFTR

    1 BioSystems Pathway for PSMB1 
        Proteasome Degradation

    5/98        Reactome Pathways for PSMB1 (see all 98)
        Ubiquitinated geminin is degraded by the proteasome
    Proteolytic degradation of ubiquitinated-Cdc25A
    Orc1 removal from chromatin
    CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway


    1         Kegg Pathway  (Kegg details for PSMB1):
        Proteasome


    PSMB1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PSMB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/195 Interacting proteins for PSMB1 (P206181, 2, 3 ENSP000002621934) via UniProtKB, MINT, STRING, and/or I2D (see all 195)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMB7Q994361, 2, 3, ENSP000002594574EBI-372273,EBI-603319 MINT-4050722 MINT-6176276 MINT-6176162 MINT-6176080 I2D: score=10 STRING: ENSP00000259457
    PSMB2P497212, 3, ENSP000003623344MINT-4050722 MINT-6176129 MINT-6176182 MINT-6176080 I2D: score=7 STRING: ENSP00000362334
    PSMB4P280702, 3, ENSP000002905414MINT-4050722 MINT-6176080 I2D: score=6 STRING: ENSP00000290541
    PSMA3P257882, 3, ENSP000002164554MINT-4050722 MINT-6176080 I2D: score=5 STRING: ENSP00000216455
    PSMA7O148182, 3, ENSP000003599104MINT-4050722 MINT-6176080 I2D: score=5 STRING: ENSP00000359910
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000084S phase of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000216M/G1 transition of mitotic cell cycle TAS--


    PSMB1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PSMB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PSMB1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PSMB1

    3 DrugBank Compounds for PSMB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Bortezomib-- 179324-69-7targetantagonist20954323 17139284 17016423
    (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE-- --target--10592235
    N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about PSMB1 / PSB1 

    Transcripts
    for PSMB1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PSMB1 gene: 
    NM_002793.3  

    Unigene Cluster for PSMB1:

    Proteasome (prosome, macropain) subunit, beta type, 1
    Hs.352768  [show with all ESTs]
    Unigene Representative Sequence: AK125435
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262193(uc003qxq.2 uc011ehe.2) ENST00000462957(uc003qxr.3)


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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB451312.1 AB451442.1 AK058050.1 AK125435.1 AK223193.1 BC000508.2 BC020807.1 BT019720.1 
    D00761.1 

    24/28 DOTS entries (see all 28):

    DT.454432  DT.100884860  DT.97862320  DT.100884856  DT.92010853  DT.95369435  DT.95369447  DT.92460556 
    DT.100039485  DT.121348521  DT.92460554  DT.121348470  DT.100726260  DT.100884842  DT.40268868  DT.95369424 
    DT.95369440  DT.100039480  DT.100039486  DT.100039488  DT.100884857  DT.100884858  DT.121348259  DT.121348480 

    24/794 AceView cDNA sequences (see all 794):

    AI928958 CB267119 AA477875 AW611710 BU738050 CR615498 AI391474 AW967310 
    CR602488 AA330525 CR621157 CF541036 CB046342 AI915540 BE795182 BI116196 
    BQ651631 BQ054536 CB134818 CN485143 AA443580 BU846331 BQ688397 BQ017568 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PSMB1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
    SP1:                                            -           -                           
    SP2:                          -                 -           -                           
    SP3:                                -           -           -                           
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for PSMB1

    Expression
    for PSMB1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PSMB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGGCTGGTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See PSMB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PSMB1

    SOURCE GeneReport for Unigene cluster: Hs.352768
        SABiosciences Custom PCR Arrays for PSMB1
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSMB1
    In Situ
    Assay Products:     
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    Orthologs
    for PSMB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PSMB1 gene from 10/39 species (see all 39)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Psmb11 , 5 proteasome (prosome, macropain) subunit, beta type more1, 5 85.29(n)1
    93.7(a)1    		   17 (8.95 cM)5
    191701  NM_011185.31  NP_035315.11 
     154757215 
    chicken
    (Gallus gallus)    		 Aves PSMB11 proteasome (prosome, macropain) subunit, beta type, more 79.01(n)
    85.53(a)    		   421551  NM_001007905.2  NP_001007906.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PSMB16
    		 --
    		 82(a)
    		 1 ↔ 1
    		 1(223195010-223209333)
    African clawed frog
    (Xenopus laevis)    		 Amphibia psmb1-prov2 proteasome (prosome, macropain) subunit, beta type more 75.7(n)    BC043739.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc51f062 wufc51f06 75.8(n)   325020  CK395346.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Pros261 , 3 ATP-dependent proteolysis proteasome
    endopeptidase3
    Proteasome 26kD subunit1    		 52(a)3
    57.7(n)1
    52.83(a)1    		   3 73B13
    398551  NM_079391.21  NP_524115.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea pbs-61 Protein PBS-6 50.25(n)
    45.69(a)    		   176161  NM_066405.3  NP_498806.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes PRE7(YBL041W)4
    PRE71    		 Beta 6 subunit of the 20S proteasome4
    Pre7p1    		 54.46(n)1
    49.3(a)1    		   2(141247-141972)4
    8522391, 4  NP_009512.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons PBF11 proteasome subunit beta type-1 54.4(n)
    49.53(a)    		   825253  NM_001203217.1  NP_001190146.1 
    rice
    (Oryza sativa)    		 Liliopsida Os09g05056001 hypothetical protein 53.27(n)
    50.24(a)    		   4347507  NM_001070138.1  NP_001063603.1 


    ENSEMBL Gene Tree for PSMB1 (if available)
    TreeFam Gene Tree for PSMB1 (if available) 

    Paralogs
    for PSMB1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PSMB1 gene

    PSMB1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PSMB1
    PGOHUM00000239972


    Genomic Variants
    for PSMB1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/397 NCBI SNPs in PSMB1 are shown (see all 397)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs122105831,2
    		C,F,H,--168367085(+) AAAGCG/TAGCCT 2 -- us2k110Minor allele frequency- T:0.10NA NS EA WA 798
    rs122108361,2
    		C,F,H,--168367512(+) TAGTCG/TTTGCT 2 -- us2k18Minor allele frequency- T:0.04NS EA NA WA 1184
    rs1121262541,2
    		--168367809(+) CTGATG/AATAAA 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs595552401,2
    		C,--168367959(-) ATTCAG/ATTCTG 2 -- us2k13Minor allele frequency- A:0.02WA 646
    rs598851431,2
    		F--168368153(-) ATAATGAT/-AACAG 2 -- us2k11Minor allele frequency- -:0.00--526
    rs178607991,2
    		C,F,--168368165(-) GTAAAA/CTTGAA 2 -- us2k11Minor allele frequency- C:0.00--526
    rs587588811,2
    		C,--168368585(-) TCACTA/GTGGGC 2 -- ut513Minor allele frequency- G:0.02WA 646
    rs412705271,2
    		--168368647(+) GAAGGC/TCACCA 2 -- int11Minor allele frequency- T:0.01NA 120
    rs69184741,2
    		C,H,--168368697(+) GGAATT/CGGCGC 2 -- int1 tfbs34Minor allele frequency- C:0.00NS EA 418
    rs178607961,2
    		F,--168369028(+) AGAAGC/TCTGAG 2 -- int12Minor allele frequency- T:0.05WA NA 238

    HapMap Linkage Disequilibrium report for PSMB1 (170844204 - 170862429 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PSMB1
         2 CNVs: 3658 3657

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    Disorders / Diseases
    for PSMB1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PSMB1 for disorders           About GeneDecksing

    OMIM gene information: 602017    OMIM disorders: --

    10 diseases for PSMB1:    About MalaCards
    visceral leishmaniasis    fanconi's anemia    rheumatoid arthritis    leishmaniasis
    anemia    arthritis    immunodeficiency    malaria
    huntington's disease    parkinson's disease

    Genetic Association Database (GAD): PSMB1
    Human Genome Epidemiology (HuGE) Navigator: PSMB1 (3 documents)

    Export disorders for PSMB1 gene to outside databases

    Publications
    for PSMB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PSMB1 gene, integrated from 9 sources (see all 91):
    (articles sorted by number of sources associating them with PSMB1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PubMed id 2025653)1, 2, 3 Tamura T.... Ichihara A. (1991)
    2. Evaluation of IDDM8 susceptibility locus in a Russian simplex family data set. (PubMed id 15848047)1, 4 Chistiakov D.A....Nosikov V.V. (2005)
    3. Interaction of plasminogen activator inhibitor-2 and proteasome subunit, beta type 1. (PubMed id 14732874)1, 2 Fan J.... Zhu Y.S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. (PubMed id 14550573)1, 2 Apcher G.S.... Krueger E. (2003)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    7. Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome). (PubMed id 2306472)1, 2 Lee L.W....Slaughter C.A. (1990)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)

    External Searches for PSMB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PSMB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5689 HGNC: 9537 AceView: PSMB1 Ensembl:ENSG00000008018 euGenes: HUgn5689
    ECgene: PSMB1 Kegg: 5689 H-InvDB: PSMB1

    Other Databases showing PSMB1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PSMB1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PSMB1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PSMB1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PSMB1 gene:
    Search GeneIP for patents involving PSMB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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